LOCUS       NZ_QGHB01000003        22472 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Lentzea atacamensis strain DSM 45480 Ga0215650_103, whole genome
            shotgun sequence.
ACCESSION   NZ_QGHB01000003
VERSION     NZ_QGHB01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Lentzea atacamensis
  ORGANISM  Lentzea atacamensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 674900)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 674900)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Expected Final Version            :: No
            Genome Coverage                   :: 90.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003148865.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:35:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,333
            CDSs (total)                      :: 9,254
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 79
            rRNAs                             :: 6, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 6 (5S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 32 of 144
            Pseudo Genes (incomplete)         :: 121 of 144
            Pseudo Genes (internal stop)      :: 2 of 144
            Pseudo Genes (multiple problems)  :: 11 of 144
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:50:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 18416
            Orig. end                         :: 40888
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QGHB01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22472
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22472
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22472
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12472](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12472)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(343..1911)
                     /locus_tag="C8D88_RS14025"
                     /old_locus_tag="C8D88_10320"
     CDS             complement(343..1911)
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013100.5"
                     /locus_tag="C8D88_RS14025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10320"
                     /product="penicillin-binding transpeptidase
                     domain-containing protein"
                     /protein_id="WP_170154872.1"
                     /transl_table=11
                     /translation="MEPKTRRWILIGGALATATTIGVAGALLWSPDPVISEKPKNQANQ
                     SVERPADVALSFVNKLSSPDAAAAAQLTDAPDAAAKAIAATRTGMAASAYQARLAATTP
                     PAPDATTTDMTASVTWTMPSSAVLKYDVKLTVQKSGEAWKVHWTPTLLHPQLTEGSSLV
                     YRAALADGALLGRDGKPLVKGTIPDGLYNTITGQTGDLKGTDGWEVGISSTAGFTKLDG
                     KAPEGGQKITVTIDPARQAAAQAAVDALPQGAAIVAIEPSTSEILAVAQNKTLSGTNPF
                     VGRYAPGSTMKIVTAAAAMNAGLVQANTAVPCPATATIGTRRISNAGFGHDSLPFHTAF
                     ALSCNTTMGELGAKLPPNALPDMAKRFGLGADWTITGADTNTGKVPPASGDQQVENSFG
                     QGNVVASPFGMALVAATVVSGKTPTPTLMRGKPPTPNDVAAAPPAATLQPLRNMMREVV
                     TTGTAKQLSGIPGLAGKTGTAEAGGGTAHGWFVGYQGNMAFAVFVENAGSSQSALTAAA
                     AFLKR"
     gene            complement(1992..2732)
                     /locus_tag="C8D88_RS14030"
                     /old_locus_tag="C8D88_10321"
     CDS             complement(1992..2732)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103566.1"
                     /locus_tag="C8D88_RS14030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10321"
                     /product="SIS domain-containing protein"
                     /protein_id="WP_109635383.1"
                     /sec_met_domain="SIS_2 (E-value: 9.6e-40, bitscore: 131.1,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDTVTGSDYGNLVRTHLTRVEQHNAAALDDVAELVLAAVQADG
                     MILTAGAGHSLAAVAETFYRAGGLACVRPIYHPELLPMHGAISSTAAERRSGLAGEVLR
                     EAGLAPHDVLFVFSTSGVNHYPVELAQEAAGAGCPVVAVTSVTASAQAPRRAGATLAEV
                     ATVVLDNLVPPGDSTYPEQAPVTAAVSTLATTFLWNLLMVRLVDKATETGVQLPLWRSA
                     NVEGGDAANADLLRHYQTRIPQLG"
     gene            2835..3017
                     /locus_tag="C8D88_RS14035"
                     /old_locus_tag="C8D88_10322"
     CDS             2835..3017
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS14035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_10322"
                     /product="hypothetical protein"
                     /protein_id="WP_109635385.1"
                     /transl_table=11
                     /translation="MGLIRRYFYIWVVLAAVFTTAGATHIALAITYSVLWPVWVAMAQL
                     IVAGGCARAAVRTRP"
     gene            3038..4024
                     /locus_tag="C8D88_RS14040"
                     /old_locus_tag="C8D88_10323"
     CDS             3038..4024
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673451.1"
                     /locus_tag="C8D88_RS14040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10323"
                     /product="phosphotransferase"
                     /protein_id="WP_109635387.1"
                     /sec_met_domain="APH (E-value: 1e-21, bitscore: 73.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAESHAPVVEMLWEAHDPLGALGGRFGFGDERAAGRWVATALGEH
                     WGVRVLSCERIVISAHNALAWVGTPDGRMIAKWSVVQELFPRLVEVARLTRWLDGRGIP
                     VSVPVPALDGRLQVEVAGASMGLQHEVEGELLDVTDAGQVREAGAVLARLQDALAAYPD
                     GDLVAAFGGPPLPLTARVTGWLDSSAGHLPGTARDALRSMLGGVPAGRLPAQLVHRDFR
                     SANVLWAGGEVAAILDFEEIALDHRVVELARSAVLLGTRFRDWGPVPAEVHAAFLAGYE
                     SVRRLTEVEAGWWEVLLRWHALAMVPEGEDPTGWGAAALGEEFHAQR"
     gene            complement(3995..4945)
                     /locus_tag="C8D88_RS14045"
                     /old_locus_tag="C8D88_10324"
     CDS             complement(3995..4945)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS14045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_10324"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_109635389.1"
                     /transl_table=11
                     /translation="MLRVHFTAEDLARVRVAPGPDPMWEILLSLHVLRQRSATPVFGTW
                     RANVRSTLPDDARWLMQLAPPVGYSPDFLTPTAGSCALDAGIDAVLATPVESLRADLAQ
                     LGRRQRLDPRTNLLASGDVATLDSLGEALRAYHRHALAPIWDEIRAVVDADRAVRARSF
                     LDSGCEGMLSALHPTISWSPPVLSIESRFPQRDVHLHGQGLVLVPSHFCWERPIMLRDQ
                     RHPPVLVYPIARDLHITTNGKRSLEALLGRTRAAALGVIAGGCTTTELARRLGISAASA
                     SAHASVLRDAGLAVAQRHRNSVLHTASALGVELLA"
     gene            5171..5779
                     /locus_tag="C8D88_RS14050"
                     /old_locus_tag="C8D88_10325"
     CDS             5171..5779
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024919.5"
                     /locus_tag="C8D88_RS14050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10325"
                     /product="C39 family peptidase"
                     /protein_id="WP_109635391.1"
                     /transl_table=11
                     /translation="MKLAKISGAVAAVGAAMTIFTAPVALAAPGETVIPAAAELGIQGE
                     GVLPHEFQVQETGYWCSAAAARIALTARGKKVEQSTLASYMKVTTNGLPNIKNLERALD
                     HYTGSTYYQVKQWSTDAQLLQELKADVVYNANRGHAVVINVIRLNGRNYSGGHYATVVG
                     YRAGGNEFAVADPAYAGGRLHWLSASNVSSGIKLRRYVA"
     gene            complement(5754..6329)
                     /locus_tag="C8D88_RS14055"
                     /old_locus_tag="C8D88_10326"
     CDS             complement(5754..6329)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103563.1"
                     /locus_tag="C8D88_RS14055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10326"
                     /product="NTP transferase domain-containing protein"
                     /protein_id="WP_109635393.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.1e-39, bitscore:
                     129.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVAGLLLAAGAGRRFGSPKALVSLHGKLFVDSAAELLRAAGCEP
                     VVVVLGAMADEVRAKASLDGVTVVDNPDWESGMGSSLRTGLHAAGIVDAVVVLPVDTPG
                     VTVAALHRLMELAEPKALARAVYDGKVGHPVLIGADHFAGVMASAAGDQGARDYLKANT
                     VRHVECGDVADGADVDRPEDLRPRNGEA"
     gene            complement(6340..7494)
                     /locus_tag="C8D88_RS14060"
                     /old_locus_tag="C8D88_10327"
     CDS             complement(6340..7494)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332019.1"
                     /locus_tag="C8D88_RS14060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10327"
                     /product="glycoside hydrolase family 105 protein"
                     /protein_id="WP_109635395.1"
                     /transl_table=11
                     /translation="MTTSRRDFVRLGGAALAGGVALGTGTASAKERIDWSVEVVESTMR
                     QFTPETLGGWGYTRGLYLWGQWLVFQRTKNKKYFDYIKAWVDRFVGPDGKFNRTFTHLD
                     SMRAGQLLPLLYNATGDVRYRVASTQIRERLNTYSRTKEGGFWHAEGGTRDWQNWSDGV
                     YMVVPFIMRHGYTFGEKDWATAEALRQLLVYAKNLQHKNGLFHHAYDESRTASWANPAT
                     GVSPEFWGRAMGWYAITCCDVLEDLPRTHPDRPKLISILGRLIAALARHQDPKSGRWFQ
                     VVDKGSNPRNWTETSCSSMYSMAISRAVERGYVSRRYEVVAQRGYRGVLERVSINAQGS
                     TEISEICIGTNVGDLPFYLARPRAVNDLHGIGAFLIMSEQFQRR"
     gene            complement(7569..8138)
                     /locus_tag="C8D88_RS14065"
                     /old_locus_tag="C8D88_10328"
     CDS             complement(7569..8138)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="C8D88_RS14065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10328"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_109635397.1"
                     /transl_table=11
                     /translation="MRTLDHLVTRSASVRAVLSSRGGIDSALLGLMSNAADRGRLLLDP
                     PLARHTETIGRVARHHVDIRVHTQPARHMLVFDDRAAVLPLDASDLNTGAVLLRCPLST
                     PYGQLFELMWSDAETLSENAPPYDGLTSREAEVIGLLLNGATDHQVAARLGMSSRTVRA
                     VVAHLQQRFGTRSRMALGFQIARSTN"
     gene            complement(8268..10004)
                     /locus_tag="C8D88_RS14070"
                     /old_locus_tag="C8D88_10329"
     CDS             complement(8268..10004)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670108.1"
                     /locus_tag="C8D88_RS14070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10329"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_109635399.1"
                     /transl_table=11
                     /translation="MRTLDLLRLASGHGRGLALAVTATLVAAGLGLLQPQLLRAAVDSA
                     TSVPWQLLAAMAVLFLAQACVDGAGLYLLERTGERVVLGVRRRLVARLLRLRMKAFDEH
                     RVGDLMSRVSVDTTVLREVVSTASVQLITGTLTGVGTVVLMVLIDPVLFLWVGTTVVVA
                     AVVVYSLVGRLRAAGEQMQRGVGDMTAELERALGALRTVRACRAEEREEELIGRRAEQA
                     CAAGVRAARITSVMSPAVELAMRGSLLVVLLVGGTRVARDAASVGDLMAFLLYATYLII
                     PFTSVLQGIGLLQKGMGALGRVAEVQELPVEGTAGGAVPECAGIRLEFRDVWFRYRDRP
                     VLRGVSFTVEPRSHVALVGLSGAGKSTLFSLIERFYEPDSGALLANGIDIRNFSRDQWR
                     ARIALVDQDSTVLNGTLRDNLSYAAPHSSDHDLHEVLELANLTELVERLPDGLDTPLGE
                     RGRALSGGERQRIALARALLTQPDLLLLDEPTAHLDPVNERALHRAIHQAAQECALLVI
                     AHRLSTIREANRIVVLRAGEVIAQGTHDELLGINGFYSGLVVGRFVDNSKSFETEISPG
                     WR"
     gene            complement(10001..10411)
                     /locus_tag="C8D88_RS14075"
                     /old_locus_tag="C8D88_10330"
     CDS             complement(10001..10411)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670107.1"
                     /locus_tag="C8D88_RS14075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10330"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_109635401.1"
                     /sec_met_domain="PF13471 (E-value: 1.9e-27, bitscore: 90.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSSLSRPTGVPLRRRIAARLAVTAATPLAHLKPRTLRRILSL
                     LRRGAKPAPYDTAKAARDAVLAVSLRCLGPQGCLPRSVAVALLCRMSGTWPTWCAGVRV
                     MPPFGAHAWVEADGVPVDENLPAQYFRPLMTV"
     gene            complement(10408..10659)
                     /locus_tag="C8D88_RS14080"
                     /old_locus_tag="C8D88_10331"
     CDS             complement(10408..10659)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.5"
                     /locus_tag="C8D88_RS14080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10331"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_109635403.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 9.1e-29,
                     bitscore: 94.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1.3e-07,
                     bitscore: 26.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.5e-17, bitscore: 57.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRADVSVADTDYGQVLLDERSGRYWQLNPTGVAVVRALLEGAD
                     ENAAVAALTSAYEVDEARARQDVSALVAGLRTAGLVTT"
     aSDomain        complement(10414..10659)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C8D88_RS14080_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.90E-30"
                     /identifier="RREFam002.1"
                     /label="C8D88_RS14080"
                     /locus_tag="C8D88_RS14080"
                     /protein_end="82"
                     /protein_start="0"
                     /score="94.7"
                     /tool="antismash"
                     /translation="MRLRADVSVADTDYGQVLLDERSGRYWQLNPTGVAVVRALLEGAD
                     ENAAVAALTSAYEVDEARARQDVSALVAGLRTAGLVT"
     gene            complement(10643..12472)
                     /locus_tag="C8D88_RS14085"
                     /old_locus_tag="C8D88_10332"
     CDS             complement(10643..12472)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="C8D88_RS14085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10332"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_109635405.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.7e-43, bitscore:
                     144.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDQASRGHGESHFVVLPDHEAALAVARRLCAPGFRSLQHASGRP
                     WLAGRWRDDEIVAAAAGDARLAVIGWCPVSVAELERAAAGLRDLTHLDELARRLPGSFH
                     LAASLGGRCRVQGTASGLRLVFHRRIGEVVVAADRADLLAQDSPVDERGLVVRLLFPTP
                     HPLLERTMWRDVECVPPGSALLVDGGRARLTRWWRDPEPVRGIAESVPLIRDALATAVD
                     VRTRAGGTVACDLSGGLDSTSITFLAARSDARIVASTWPALDPVDEDVAWARRAAAHLP
                     MVEHVVWPAERIPLVYENLLGIDDPMDEPTIGMMDRQRLLEDLKGLAEKGSRVRLTGIG
                     GDHVAWCSEAHYHPLLRRRPLFAIRQLRAFRALFDWPLKPMISALADSRSYGAWLADEA
                     ERLRAPRDPNVIGTLGWGTGPRLFDWVTPEAQALARDTLLDAAATAEPLGRNRGEHGDL
                     EPILSCSRIIRQWEQMSARAGLPIQSPFLDDRVIEACLSVRPEERVTPWRYKPVLTEAM
                     RGIVPDECLARTNKAQAALEASAGLRRHRGDLLELWESSKLADLGLVDRRRLTELALRP
                     DTPELRTGILYSTIGCEVWLRSLDKGAEHAVAG"
     gene            complement(12489..12590)
                     /locus_tag="C8D88_RS14090"
                     /old_locus_tag="C8D88_10333"
     CDS             complement(12489..12590)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039305.4"
                     /locus_tag="C8D88_RS14090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10333"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_109635407.1"
                     /transl_table=11
                     /translation="MYETPQLIDLGTFEAQTGLLQRNGNDRLIFSKN"
     gene            complement(12718..13542)
                     /locus_tag="C8D88_RS14095"
                     /old_locus_tag="C8D88_10334"
     CDS             complement(12718..13542)
                     /NRPS_PKS="Domain: Abhydrolase_1 (25-155). E-value:
                     4.7e-22. Score: 70.7. Matches aSDomain:
                     nrpspksdomains_C8D88_RS14095_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642197.1"
                     /locus_tag="C8D88_RS14095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10334"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_109636433.1"
                     /sec_met_domain="PF00561 (E-value: 9.1e-17, bitscore: 56.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.1e-16, bitscore:
                     55.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDHLSIETEAGTFDAIASGPEDGRPVLLLHGFPEAAIEWEHQVA
                     VLGANGFRAVAPDQRGYSPGVRPEQSSEYTVTHLVGDVIAMADAQGWSTFDLVGHDWGG
                     AVAWWTAIDHPDRLRTLSVFSTPHPGALKTALQTDEEQRMRSQYMLDWRERSTERRMLE
                     NNAHALRQMFEYRIRPSHVDEYIQRLSEPGALSAALNWYRAGKPSGTADKVAVKTMYVW
                     STEDVAFGSVAAFETEKWCTGPYRFEMVEDVSHWIPEEIPEAASSLLLEHLS"
     aSDomain        complement(13078..13467)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C8D88_RS14095_Abhydrolase_1.1"
                     /evalue="4.70E-22"
                     /label="C8D88_RS14095_Abhydrolase_1.1"
                     /locus_tag="C8D88_RS14095"
                     /protein_end="155"
                     /protein_start="25"
                     /score="70.7"
                     /tool="antismash"
                     /translation="PVLLLHGFPEAAIEWEHQVAVLGANGFRAVAPDQRGYSPGVRPEQ
                     SSEYTVTHLVGDVIAMADAQGWSTFDLVGHDWGGAVAWWTAIDHPDRLRTLSVFSTPHP
                     GALKTALQTDEEQRMRSQYMLDWRER"
     misc_feature    complement(13535..13550)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.47"
                     /tool="antismash"
     misc_feature    13942..13954
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.55"
                     /tool="antismash"
     gene            14124..14810
                     /gene="shbA"
                     /locus_tag="C8D88_RS14100"
                     /old_locus_tag="C8D88_10335"
     CDS             14124..14810
                     /codon_start=1
                     /gene="shbA"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103556.1"
                     /locus_tag="C8D88_RS14100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10335"
                     /product="RNA polymerase sigma factor ShbA"
                     /protein_id="WP_233439415.1"
                     /transl_table=11
                     /translation="MVQPTAVRTGGGVGVLDPEEVWNQPTVPMRRRVRQAPVSNQWLAE
                     AEFTDLVDAALDGDRRAVEHLLGRIQPLIVRYCRARVGGRERTLVSAEDIAQEVCVAVL
                     GALSKYRYEPQSFLAFVYGIAAHKVADARRRAVRNRAEVVPELPDCPSLDDGPEQHAVN
                     GEMMAQVTRLLHKLPARQREILVLRVAVGLSAEEVALAVESTPGAVRVAQHRALTRMRE
                     MIAEEG"
     gene            complement(14773..15438)
                     /locus_tag="C8D88_RS14105"
                     /old_locus_tag="C8D88_10336"
     CDS             complement(14773..15438)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228236.1"
                     /locus_tag="C8D88_RS14105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10336"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_109636435.1"
                     /transl_table=11
                     /translation="MTESTRPYRSELRQRQAAETRRRVVEAAAELFSRQGYQATTFAQL
                     ATEAGVSVETVQRHGPKSALLQAALELVSFGVEGETDLLATDLGKAMLQVSGTAELATL
                     IGDAMLAINAPSAGLWVAVASAAQGDEELRGYYAANLALLRRQVEHVFHVFAERGWLRA
                     DVPFDDLVEAFCVITSVEAYVRFVRLDGKPGDAYAAFVARTVGETILSPPRRSSPASG"
     misc_feature    15468..15485
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.03"
                     /tool="antismash"
     gene            15527..16819
                     /locus_tag="C8D88_RS14110"
                     /old_locus_tag="C8D88_10337"
     CDS             15527..16819
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228237.1"
                     /locus_tag="C8D88_RS14110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10337"
                     /product="glycosyltransferase"
                     /protein_id="WP_109635409.1"
                     /sec_met_domain="MGT (E-value: 9.1e-46, bitscore: 152.2,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASLIIATVPVHGHVTPLLAVARYFTQRGDRVRFITGARFAEVVE
                     AAGAEHIALPAEADFDDRQDFGVTFPERTALKGAKAIAFDLENVFVRPGRAHYKVIEAA
                     QSAEPADVVITEPAFLGGAFLVCRPLGERPPVVVCGVLPLPISSRDTAPYGMGLTPLRG
                     PLGRLRNALLTTIAARTVFTAAERLAQEINHKLNGSPLPFPIMDWLRHAEAIVQFTVPE
                     FEYPRSDAPATLHFAGPISASGSQAPLPSWWDELDGSRPVVHVTQGTVANHDYRQIIEP
                     TLAALADDDVLVVVSTGGRPLSILPPLPSNARAAEYLPYDELLPKTQVYVTNGGYGGVQ
                     YALRHGVPIVTSGGKEDKPEVAGRVAWSGVGRALRTETPSPAAVGRAVRAVLGDPRYRA
                     RARRIAASMERAGGLPRLAEIVDRQLSGRRS"
     aSDomain        16830..17276
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C8D88_RS14115_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="3.00E-12"
                     /label="C8D88_RS14115_Polyketide_cyc2.1"
                     /locus_tag="C8D88_RS14115"
                     /protein_end="149"
                     /protein_start="0"
                     /score="39.1"
                     /tool="antismash"
                     /translation="MTRFEVITGIAAPPHRVFDLSLDVDVHTASMAGSGERIVGGISSG
                     RMGLGDTVTWQAGHFGVRWRMTSCITALDRPHHFVDEQVAGPFRRWHHAHHFEPDGRGG
                     TRMRDVVEFAAPLSPLGRLAERLVLDRYMAELIRQRNDHLRTVAE"
     gene            16830..17297
                     /locus_tag="C8D88_RS14115"
                     /old_locus_tag="C8D88_10338"
     CDS             16830..17297
                     /NRPS_PKS="Domain: Polyketide_cyc2 (0-149). E-value: 3e-12.
                     Score: 39.1. Matches aSDomain:
                     nrpspksdomains_C8D88_RS14115_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644362.1"
                     /locus_tag="C8D88_RS14115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10338"
                     /product="SRPBCC family protein"
                     /protein_id="WP_109635411.1"
                     /transl_table=11
                     /translation="MTRFEVITGIAAPPHRVFDLSLDVDVHTASMAGSGERIVGGISSG
                     RMGLGDTVTWQAGHFGVRWRMTSCITALDRPHHFVDEQVAGPFRRWHHAHHFEPDGRGG
                     TRMRDVVEFAAPLSPLGRLAERLVLDRYMAELIRQRNDHLRTVAELAPGDP"
     misc_feature    complement(16879..16894)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.25"
                     /tool="antismash"
     gene            complement(17260..18456)
                     /locus_tag="C8D88_RS14120"
                     /old_locus_tag="C8D88_10339"
     CDS             complement(17260..18456)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.5"
                     /locus_tag="C8D88_RS14120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10339"
                     /product="MFS transporter"
                     /protein_id="WP_170154873.1"
                     /transl_table=11
                     /translation="MGVPLRKNVQFQLLWLGGTVSQLGTQLTTYAMPLLILAVTGSFFW
                     AGVIAGVRATTLILTQMPAGVWVDRWDRGKVLVWSQTTQAVAVAAMAANVVTGLNSIPL
                     FIALAAVDGVCTAFAGPARSTAIKAVVPPDRLRTAFAQEEARGHVAWLAGPSLGALLYG
                     FGRAVPFAADAVTFLVAAVCAWFAKIPARTEQRPRGRVRHDVREAWTWLWRRRGMRNVV
                     AIFLTLNLLGTASMIPVVAVVKERGGPDWLVGLVLTGVGVGGLLGALISPKVTLRYDRL
                     IVAVLTVFGVSNLAMALPFGAWWPFVPLMVTAIATPLLNVSVSAIFTGLVPDDLMGRID
                     AILTFASRALTPLAPVLGAFLADLAGGALALLVFGALILVTALVAEFTDLRAPAPQLS"
     misc_feature    complement(18493..18509)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    complement(18495..18508)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            18509..19537
                     /locus_tag="C8D88_RS14125"
                     /old_locus_tag="C8D88_10340"
     CDS             18509..19537
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_function="GO:0016773 - phosphotransferase activity,
                     alcohol group as acceptor [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667375.1"
                     /locus_tag="C8D88_RS14125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10340"
                     /product="carbohydrate kinase family protein"
                     /protein_id="WP_109635415.1"
                     /transl_table=11
                     /translation="MADPDFDVLLTGTVFLDIIFTGLPRPPAAGTEVWAEGLGSCPGGI
                     ANLAVALRRLELRTALAAAFGEDAYGDFCWDVLSEQEGVDLSYCRRFYGWHSPVTVSMA
                     MERDRSMVTHGHEAPVIADDLFCPPPSTRACFVHIQAEDEQWVRTAKENGALLFADIGW
                     DRTGAWSPELLRRLEGYDVFLPNHVEAQGYTRTDSPEAAARKLSEHVPVVVVTRGGGGA
                     VAVDSSTGEVADVPGLNVAQLDPTGAGDVFGAGFVMGTLAGWPLEHRVRFANLCAALSV
                     QHFGGSLSAPGWGDIAVWWRTVSRRPDEELARYGFLDDVLPDHAGVEVRRASPTIGLRL
                     LR"
     misc_feature    18555..18569
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.93"
                     /tool="antismash"
     gene            19658..21751
                     /locus_tag="C8D88_RS14130"
                     /old_locus_tag="C8D88_10341"
     CDS             19658..21751
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016701212.1"
                     /locus_tag="C8D88_RS14130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_10341"
                     /product="transglycosylase domain-containing protein"
                     /protein_id="WP_233439416.1"
                     /transl_table=11
                     /translation="MVKLLGLCLTAGVLLAAMVFPFVGGLGLASNRAADTVDQTSGDLA
                     KGELPLVTTIQDMNGDPIAYLYDQYRIPLASSDISDTMKAAILAIEDKRFYDHRGVDWQ
                     GIARAAAKAGVDGGATQGASTLTQQYVKNYMAFVLGADNEQEAWEKATEATIGRKMREA
                     RVALQLEQQMSKEEILTGYLNIVPLGNQTYGVGAAAKAYFKTTADKLTVPQAALLAAIA
                     NRPSSLNPGASPEKALERRNIVIDKMRENGAFGTDQTEAQKKAEEYKAAPLGVVDDLQI
                     LPKGCVGAGDGPIYGFFCSYLLDYLRESGITNKELQRGGLTIKTTMDPKATKAAKTSAE
                     QQVPKTQNGISNVMSVVEPGKDKHRVRALVASRDYGNKAELGQVARPVPAEVLPFGPGS
                     VNKVFTAAAALEKNVIGIDKEMAVPKVYYSRVYPNGGAPWKVENAGTYGEKMSLTQALA
                     QSPNTGFVILQEKTGLDSVVDMAYRLGMRETLQGVNRAGEPLKDDKSNGPSQGDWTKQN
                     NAGSYTLGPGATSVLELANVAATIVSGGTWCPPSPVEKVIDRYGKEVPLKEKPCEQAVN
                     TELANSLAQGMSHDTTGQGTAAQAASGSGWNRPTIGKTGTTEEHKSVAFMAATPQYAGA
                     VMTYADGNRPEVICANPIRFCPGSNQGVYGGQVAAPTWFNAMKVIHEGLPVVPLPPAAA
                     RYK"
ORIGIN
        1 gttttcttcg gctgaggttg ggcagaggta ctgatctttt ggggtccgta ggtgggcgcg
       61 ttggcatcgg acgcggcggt tgcgaggatt tctggggctc cgccccggac cctgccaacc
      121 tgatcaagga tccgccagcg ccacgcgcag gtagatggca cgcctgtgcc gttgggcggc
      181 ttgcggttgc gttgttggtt gcggtgtggc tgggtcccgt cacaagccgt acctgagcgg
      241 caaacgatcg ggcacgactc gtgacgggac ccaccccacc ggcccgcgtt gtgaaaagca
      301 gctcggcttc gccgtcgcct tttgctcggc ttgctgttgc cgttagcgct ttaggaaggc
      361 tgctgcggcg gttagggcgc tttgggacga gcctgcgttt tctacgaaca ccgcgaaggc
      421 catgttgccc tggtagccca cgaaccagcc gtgggctgtg ccgccgcctg cttctgcggt
      481 gccggttttg cctgccaggc ccgggatgcc ggagagttgt ttggccgttc ccgtggttac
      541 cacctctcgc atcatgttgc ggagaggctg gagggttgcg gctggtgggg cggcggccac
      601 gtcgttgggt gtcggcggct tgcctcgcat gagggtgggc gtgggggttt tgccggagac
      661 cacggttgcc gctaccaggg ccatgccgaa cgggctggct accacgttgc cctggccgaa
      721 gctgttttcc acctgctggt cgccggaggc cggggggact ttgccggtgt tcgtgtcggc
      781 gcccgtgatg gtccagtcgg cgcccaggcc gaagcgcttg gccatgtccg ggagggcgtt
      841 cggtgggagt tttgcgccca gttcccccat ggtcgtgttg caggagaggg cgaaggccgt
      901 gtggaagggc agggagtcgt ggccgaagcc cgcgttgctg atgcggcggg tgccgatggt
      961 ggcggtggcc gggcacggga ctgcggtgtt ggcttggacg aggcctgcgt tcatggcggc
     1021 ggctgcggtc acgattttca tcgttgagcc cggggcgtag cggcctacga acgggtttgt
     1081 gccggacagg gttttgtttt gggccacggc caggatttcg ctggttgagg gctcgatcgc
     1141 cacgatggcc gcgccctgcg ggagggcgtc cactgcggct tgggctgctg cttggcgggc
     1201 cgggtcgatc gtcactgtga tcttttggcc gccttctggg gccttgccgt ccagcttggt
     1261 gaagcctgcg gtggaggaga tgcccacttc ccagccgtcg gtgcctttga gatcgccggt
     1321 ctggccggtg atcgtgttgt agaggccgtc tgggatggtg cccttgacca gtggtttgcc
     1381 gtcgcggccc aggagggcgc cgtcagcgag ggccgcgcgg tagacgaggg agctgccctc
     1441 ggtcagttgc gggtggagca gcgtcggcgt ccagtggacc ttccaggctt cgccggactt
     1501 ctgcacggtg agtttgacgt cgtacttcag cacggcggag ctcggcatcg tccacgtcac
     1561 ggaggccgtc atgtccgttg tggtggcgtc gggggccggt ggtgttgtcg cggccaggcg
     1621 ggcttggtag gcggaggcgg ccatgcccgt tctggtggcg gcgatcgcct tggcggcggc
     1681 gtccggtgcg tcggtcagct gggcggctgc ggcggcgtcg gggctggaca gcttgttcac
     1741 gaaggacagg gctacgtcgg ccggtcgttc gaccgactgg ttcgcctggt tcttcggctt
     1801 ttccgagatg accggatccg ggctccagag cagtgcgccc gccacaccga tcgtggtggc
     1861 tgtggcgagc gcgccgccga tcaggatcca tctacgtgtt ttcggctcca ctggtgaagt
     1921 ccccccaggt aagtgctttc cccggtggga gactaacgcg aagacgttga aaagctgctg
     1981 agtattgcta ctcaacccag ctgcgggatg cgggtttggt agtgcctgag caggtcggcg
     2041 ttggccgcgt cgcctccttc cacgttggcg ctgcgccaca gcggcagttg cacgccggtt
     2101 tcggtggcct tgtcgaccag gcggaccatc agcaggttcc agaggaacgt ggtggcgagg
     2161 gtggagacgg cggcggtgac cggggcctgt tccgggtagg tggagtcgcc gggcgggacg
     2221 aggttgtcca ggacgacggt ggccacctcg gcgagggtgg cgccggcgcg gcggggggcc
     2281 tgggcgctgg cggtgaccga ggtgacggcg actaccgggc agcctgcccc ggcggcctcc
     2341 tgggccagtt ccaccgggta gtggttgacg cccgaggtgg agaagacgaa gaggacgtcg
     2401 tgcggggcca ggcccgcttc gcggaggacc tcgcccgcca ggcccgagcg gcgttcggcc
     2461 gcggtgctgc tgatggcgcc gtgcatcggg agcagttccg ggtggtagat cgggcggacg
     2521 caggccaggc cgcctgcccg gtagaaggtt tcggcgaccg ctgccaggga gtggccggcg
     2581 cccgcggtga ggatcatacc gtccgcctgt acggcggcca gcacgagctc ggccacgtcg
     2641 tcgagcgctg ccgcgttgtg ctgttcgacg cgtgtcaggt gcgtgcgcac gaggttgccg
     2701 tagtcggagc cggtcacggt gtcggtcgtc atgcgggtca gtagtaccgg aagtgccgtg
     2761 ggctcaccag taacccgagc accacaaacc tcgatacgcg cgataacagg tgcggtcact
     2821 cttggcgagc ggaggtgggt ttgatcaggc ggtacttcta catctgggtt gtgctggcgg
     2881 cggtcttcac gaccgcgggg gccacgcaca tagcgctcgc gatcacctac tccgtgttgt
     2941 ggccggtgtg ggtggcgatg gcgcagctca tcgtcgcggg tgggtgtgcg cgggcggcgg
     3001 tacgcacgcg gccttaggtt tcgtgtgtca tgggtgcatg gctgaatcgc atgcgccggt
     3061 ggtggagatg ttgtgggaag cgcacgatcc gctcggtgcg cttgggggca gattcggctt
     3121 cggagacgag cgggcggctg ggcgctgggt cgccaccgcg ctgggcgagc actggggtgt
     3181 tcgggttctt tcgtgcgagc ggatcgtcat cagcgcacac aacgcgttgg cgtgggtcgg
     3241 tacgccggac gggcggatga tcgcgaagtg gtcggtggtg caggagctgt ttccgcggct
     3301 ggtggaggtc gcgcggctca cgcggtggct ggacggccgg gggatcccgg tttcggtacc
     3361 ggttcccgcg ttggacgggc gtctgcaggt cgaggtggcc ggtgcctcga tgggattgca
     3421 gcatgaggtc gagggtgagc tgctcgacgt caccgatgcc ggccaggtgc gtgaggccgg
     3481 ggcggtgctg gcccggttgc aggacgcgtt ggcggcgtat cccgacggtg atctggttgc
     3541 cgcgttcggc ggtccgccgc tgcctctgac ggctcgggtc accggctggc tcgactccag
     3601 cgcggggcac ctgcccggga cggcgcggga cgccttgcgc tcgatgctcg gcggtgtgcc
     3661 tgccgggcgg ctgccggcgc agctcgttca tcgcgacttc cggtccgcca acgtcctgtg
     3721 ggccgggggc gaggttgccg cgatcctcga cttcgaggag atcgcgctcg accaccgggt
     3781 cgtcgagctg gcgcggtcgg cggtcctgct cgggacccgc ttccgcgact gggggccggt
     3841 gccggccgag gtgcacgcgg cgttcctcgc gggctatgag tccgtgcgcc ggttgaccga
     3901 ggtcgaggcc ggctggtggg aggtgcttct gcggtggcac gccctggcga tggtgccgga
     3961 aggtgaggat ccgaccgggt ggggagcggc ggcgctaggc gaggagttcc acgcccagcg
     4021 ctgaggccgt gtgcaggacg gagttgcggt gccgctgggc cacggccagg cccgcgtcgc
     4081 gcaggaccga ggcgtgggcg ctggccgacg cggcggagat gcccaggcgg cgggcgagct
     4141 ccgtggtcgt gcagccgccg gcgatgaccc ccagcgccgc cgcgcgggtg cggcccagga
     4201 gcgcctccag tgagcgtttg ccgttggtcg tgatgtggag atcgcgggcg atcgggtaga
     4261 cgaggaccgg cgggtggcgc tggtcgcgga gcatgatcgg gcgttcccag cagaagtggg
     4321 acgggaccag tacgaggcct tggccgtgca ggtggacgtc gcgctgcggg aagcgggact
     4381 cgatcgacag cacgggcggg gaccacgaga tggtcgggtg cagggccgag agcatgccct
     4441 cgcagccgct gtccagaaag gacctcgccc gcaccgcgcg gtccgcgtcg acgacggcgc
     4501 ggatctcgtc ccagatcggg gccagcgcgt ggcggtggta ggcgcgcaac gcctcgccga
     4561 gtgagtccaa agtggccacg tcgccgctgg ccagcaggtt ggtgcgcggg tcgagtcgtt
     4621 gccggcggcc cagttgcgcg aggtcggcgc gcaacgactc cacgggcgtc gccaggacgg
     4681 cgtcgatgcc cgcgtcgagt gcgcaggagc ctgcggtggg cgtcaggaag tcgggggagt
     4741 agccgacggg cggcgccagc tgcatgagcc agcgcgcgtc gtcgggcagg gtcgatcgca
     4801 cgttcgcgcg ccacgtgccg aacaccgggg tcgccgaacg ctgccgcagc acgtgcaggc
     4861 tcagcaggat ctcccacatc gggtcgggac caggggcgac gcgcaccctc gccaggtcct
     4921 ccgccgtgaa gtggacacgc aacacggcaa gcagagtggc acagcgccgc agggcttgta
     4981 ccggattcga gacgactcag ccgaacggtc cactccaccc acccagcgtg ggtgtgaaca
     5041 gtccgttgag tgcttctacc tggcttttta ggacttggcc gaatctggtg gcgagtgttc
     5101 gcgggctgcc agcaagcttt cgccgagcgc cgcgccaggg gttcggcgcc accactgagg
     5161 ggaacgagag atgaagcttg cgaagatcag cggggctgtc gccgccgtcg gcgcggcgat
     5221 gaccatcttc accgcgccgg tcgcgctggc cgcgccgggc gagaccgtca tcccggccgc
     5281 cgcagagctc ggcatccagg gtgaaggtgt tctgccgcac gagttccagg tgcaggagac
     5341 cggctactgg tgttccgctg ccgccgcccg catcgcgctg accgcgcgcg gcaagaaggt
     5401 cgaacagtcc actctggcct cgtacatgaa ggtcacgacc aacggcctgc cgaacatcaa
     5461 gaacctcgag cgcgccctcg accactacac cggctcgact tactaccagg tcaagcagtg
     5521 gtcgaccgac gcgcagctgc tgcaggagct caaggccgac gtcgtctaca acgccaaccg
     5581 cggccacgcc gtcgtgatca acgtgatccg cctgaacggc cgcaactact ccggcggcca
     5641 ctacgccacg gtcgtcggct accgcgccgg tggcaacgag ttcgccgtgg ccgacccggc
     5701 ctacgcgggc ggccggctcc actggctgag cgcgtccaac gtgtcgtcgg gcatcaagct
     5761 tcgccgttac gtggcctgag gtcttccggt cgatcaacgt cagcaccgtc cgccacgtca
     5821 ccgcattcga cgtggcggac ggtgttggct ttgaggtagt cccgcgcgcc ctggtcgccc
     5881 gctgccgacg ccatcacgcc cgcgaagtgg tcggcgccga tcaggaccgg gtgcccgacc
     5941 ttgccgtcgt agaccgcgcg tgccaacgct ttcggctcgg cgagttccat caggcggtgc
     6001 agggcggcga cggtgacgcc gggtgtgtcc acgggaagca ccacaacggc gtcgacgatg
     6061 ccggccgcgt gcaggcccgt tcgcagcgac gagcccatgc cggactccca gtcggggttg
     6121 tcgacgacgg tcacgccgtc caaagaggcc tttgcccgca cctcgtccgc catggcgccg
     6181 aggacgacga cgaccggctc gcacccggca gcgcgtagca gctcagccgc cgagtcgaca
     6241 aaaagcttgc cgtgcaacga gacaagagct ttgggggagc cgaaccggcg gccggccccc
     6301 gcagctagca ggaggccggc cacgcgcatg cctccgaacc tacctccttt ggaactgctc
     6361 gctcatgatg aggaacgccc cgatgccgtg caggtcgttc acggctctcg gccgggcgag
     6421 gtagaacggc aggtcaccga cattcgtgcc gatgcagatc tcggagatct cggtggagcc
     6481 ctgtgcgttg atcgacacgc gttccagcac cccgcgatag ccgcgctgcg ccacgacctc
     6541 gtacctgcgc gacacatatc cgcgctcgac ggcacgtgag atcgccatcg agtacatcga
     6601 cgagcacgag gtctcggtcc agttccgcgg gttcgagccc ttgtccacga cctggaacca
     6661 gcgcccggac ttcgggtcct ggtggcgtgc gagtgccgcg atcagcctgc cgaggatcga
     6721 gatcagcttc ggccggtcgg ggtgggtgcg cggcaggtcc tccagcacgt cgcagcacgt
     6781 gatcgcgtac cagcccatcg ccctgcccca gaactccggc gacacgcccg tcgccggatt
     6841 cgcccacgag gccgtgcgcg actcgtcgta cgcgtggtgg aagagaccgt tcttgtgctg
     6901 caggttcttc gcgtagacga ggagctgccg caacgcctcg gcggtcgccc agtccttctc
     6961 cccgaacgtg tacccgtgcc gcatgatgaa cggcacgacc atgtagacgc cgtccgacca
     7021 gttctgccag tcgcgcgtgc cgccctcggc gtgccagaag ccgccttcct tggtgcgcga
     7081 gtaggtgttc agacgctcgc ggatctgcgt cgaggcgacg cggtaccgca cgtccccggt
     7141 cgcgttgtag agcaacggca acagctggcc cgcgcgcatc gagtcgaggt gcgtgaacgt
     7201 ccggttgaac ttcccgtccg gaccgacgaa gcggtccacc cacgccttga tgtagtcgaa
     7261 gtacttcttg ttcttcgtgc gctggaagac gagccactgc ccccagaggt agagcccgcg
     7321 cgtgtagccc cagccgccga gcgtctccgg cgtgaactgc cgcatggtcg actcgacgac
     7381 ctcgaccgac cagtcgatgc gctctttcgc cgacgccgta ccggttccca gagcgacgcc
     7441 accggctagt gcggcgccgc cgagtctgac gaagtcgcgc ctggacgtgg tcatggtgtt
     7501 ccctccaagg ggcgtgccga ggcggcggca cccacgacct aacttggtca gaactccgat
     7561 gtctagacct aattcgtcga tctggcgatc tggaagccga gcgccatgcg tgatcgtgtt
     7621 ccgaagcgct gttgcagatg ggctaccact gcacgcacgg tgcggctgct catgccgagt
     7681 cgggcggcga cctggtgatc tgtcgccccg ttcagcagaa gtccgatgac ttcggcttca
     7741 cggctggtca ggccgtcgta cggcggagcg ttctcggaga gagtctccgc atccgaccac
     7801 atcagctcga acagctggcc gtacggagtg gagagcgggc agcgcagcag cacggcgccg
     7861 gtgttgaggt cgctcgcgtc gagcggcagg acggcggccc tgtcgtcgaa gaccagcatg
     7921 tgacgcgccg gctgggtgtg tacccggatg tccacgtggt gccgtgccac gcgcccgatc
     7981 gtctcggtgt gcctggcgag cggtgggtcg agcagcaggc ggcctcggtc ggcggcgttg
     8041 ctcatgaggc cgagcagggc gctgtcgatg ccgccgcggc tcgacagcac cgctctgacc
     8101 gacgcggacc tggtcacgag gtggtcgagc gtgcgcatca ccgaagagcg gtcgtgaagg
     8161 acctcgacga attcggtgcg gcctgatgga gatcgctgca acacgacttc gccttccttt
     8221 cgaatgctga cggctcagtc atgttcgcat cgacggcgtc gaacgtccta cctccatcca
     8281 ggggatattt cggtctcgaa cgacttagaa ttgtcaacga atctgcccac caccagcccg
     8341 ctgtagaaac cgttgatgcc gagcaactcg tcgtgcgtgc cctgggcaat gacttcgcct
     8401 gcgcgcaata ccacgatccg gttggcttcg cgaattgtcg acagccggtg tgcgatcacc
     8461 agcaatgcgc actcctgtgc ggcctggtga atcgcgcggt gcagcgcccg ttcgttcacc
     8521 gggtcgagat gggcggtggg ctcgtcgaga aggagcaggt caggctgggt cagcagagcc
     8581 cgggccagtg cgatgcgctg acgttccccg ccggacaacg ctcgtccgcg ttcacccaat
     8641 ggtgtgtcca gtccgtccgg aagccgctcg acgagttcgg tgagattcgc gagttccagt
     8701 acttcgtgaa gatcgtgatc ggacgaatgc ggcgctgcgt aactgagatt gtcacggagt
     8761 gtgccgttga gaactgtcga gtcctgatcc accagcgcaa ttcgtgcacg ccattggtca
     8821 cgggaaaagt tccgaatgtc gatcccgttt gcgagcagag ctccggaatc gggttcgtag
     8881 aaccgctcga tcagcgaaaa cagggtcgac ttgccggcac cggacagccc gaccagcgcg
     8941 acgtgcgacc gcggctcgac ggtgaacgag acaccgcgca gcaccgggcg gtcccggtag
     9001 cggaaccaga cgtcgcggaa ctccagcctg atccccgcac actcgggcac cgcgccgccc
     9061 gcggtgccct cgaccggcag ctcctgcacc tcggcgaccc tgccgagcgc gcccatgccc
     9121 ttctgcagca gcccgatgcc ctgcagcacc gaggtgaagg ggatgatcag gtaggtcgcg
     9181 tagagcagga acgccatcag gtcgccgacc gacgccgcgt ccctcgcgac ccgcgtgccg
     9241 ccgacgagca gcaccacgag caacgacccg cgcatcgcca gttcgacggc ggggctcatc
     9301 accgacgtga tccgcgcggc ccgcaccccg gccgcgcacg cctgctcggc acgtcgcccg
     9361 atcagctcct cttcgcgttc ctccgcccgg cacgcgcgca cggtgcgcaa cgccccgagc
     9421 gcgcgctcca gttccgcggt catgtcaccg acgccgcgtt gcatctgctc gccggcggca
     9481 cgaagcctgc cgaccagcga gtagacgacc acggcggcga ccacgacggt cgtgcccacc
     9541 cacaggaaca acaccgggtc gatcagcacc atcagcacca cggtgccgac gcccgtgagc
     9601 gtgccggtga tcagctggac cgacgcggtg gagacgacct cgcgcaacac cgtcgtgtcg
     9661 acgctgaccc gcgacatcag gtcgcccacc cggtgctcgt cgaacgcctt catccgcagc
     9721 cgcaacaacc gggccaccag cctgcgccgc accccgagca cgacacgttc cccggtgcgc
     9781 tccaacaggt acagccccgc accgtcgaca cacgcctgcg cgaggaacaa cacggccatc
     9841 gccgcgagca gctgccacgg caccgacgtg gccgagtcga cggcggcacg cagcaactgg
     9901 ggctggagca gtccgagccc ggccgcgacc agcgtcgccg tcacggccag tgcgagaccg
     9961 cgcccgtgcc cggaggccag ccgcagcagg tcgagcgtcc tcataccgtc atcaggggac
    10021 ggaagtactg agcgggcagg ttctcgtcga cgggcacgcc gtccgcctcg acccaggcgt
    10081 gcgccccgaa cggcggcatc acgcgcacgc cggcacacca cgtcggccac gtgcccgaca
    10141 tccggcacag cagtgccacg gcgacggacc tcggcaggca accctgcggg ccgaggcacc
    10201 gcaggctcac cgccagcacg gcgtcccgtg ccgctttggc ggtgtcgtag ggggcgggtt
    10261 tggcgcctcg gcggaggagg ctcaggatcc ggcgcagggt gcgcggcttg aggtgggcca
    10321 gcggggtggc ggccgtgacc gccaggcggg ccgcgatgcg gcggcggagc gggacgccgg
    10381 tggggcggct gagtgacgag ggtgtggtca cgtcgtcacc aggcccgcgg tccgcagccc
    10441 cgccaccagg gccgacacgt cctgccgcgc ccgtgcctcg tccacctcgt acgcggaggt
    10501 gagcgccgcg acggccgcgt tctcgtcggc cccctcgagc aacgcccgca ccacggccac
    10561 gccggtcggg ttgagctgcc agtaccggcc gctgcgctcg tcgagcagca cctggccgta
    10621 gtcggtgtcc gccacggaaa cgtcagcccg caaccgcatg ttctgctccc ttgtccaggc
    10681 tgcgcaacca cacctcgcag ccgatcgtcg agtacaagat cccggtgcgg agctctggcg
    10741 tgtccggccg caacgcgagc tcggtcagcc tgcggcggtc gaccaggccc aggtcggcga
    10801 gcttcgagct ctcccacagc tccagcaggt caccgcggtg cctgcgcagg ccggccgagg
    10861 cctccagcgc cgcctgcgcc ttgttcgtcc gcgccaggca ctcgtccggc acgatcccgc
    10921 gcatcgcctc ggtgagcacg ggcttgtagc gccacggcgt cacgcgttcc tccggccgca
    10981 ccgacaggca cgcctcgatc acgcggtcgt ccaggaacgg tgactggatc ggcagtcccg
    11041 cccgcgcact catctgctcc cactgccgga tgatgcgcga gcaggacagg atcggctcca
    11101 ggtcgccgtg ctcgcctctg ttgcgcccca acggttccgc tgtcgcggcg gcgtccagca
    11161 gcgtgtcgcg ggcgagtgcc tgtgcctcgg gcgtcaccca gtcgaacaac ctcggtccgg
    11221 tgccccagcc gagtgtgccg atgacgttcg ggtcgcgcgg cgctcgcagt cgctcagcct
    11281 cgtccgcgag ccacgcaccg tacgagcggg agtccgcgag cgctgagatc atcggcttca
    11341 gcggccagtc gaacagcgcc cggaacgcgc gcagctgccg gatcgcgaac aacggccgcc
    11401 tgcgcagcaa cgggtggtag tgcgcttcgg agcaccaggc gacgtgatct ccgccgatgc
    11461 cggtcagccg gacccggctt cccttctccg ccaagccttt caggtcctcc agcaggcgct
    11521 ggcggtccat catcccgatg gtgggctcgt ccatcgggtc gtcgatgccg agcaggttct
    11581 cgtacaccag cgggatgcgt tcggccggcc acacgacgtg ctcgaccatc ggcaggtgcg
    11641 ccgcggctcg ccgtgcccag gccacgtcct cgtccaccgg gtccagcgcg ggccaggtgc
    11701 tggccacgat ccgcgcgtcc gacctggccg cgaggaacgt gatcgacgtg gagtccagcc
    11761 caccggagag atcgcacgcg acggtgccgc ctgctcgcgt gcggacgtcg accgcggtgg
    11821 cgagggcgtc cctgatcaac gggacggact ccgcgatgcc gcgcaccggt tccgggtcgc
    11881 gccaccaccg ggtcagccgg gcgcggccgc cgtcgaccag caacgcgctg ccgggcggta
    11941 cacattccac atcgcgccac atcgtccgtt ccagcaacgg gtgcggcgtg gggaagagca
    12001 gtcgcacgac caggccccgt tcgtccacag gggagtcctg ggccagcagg tccgcacggt
    12061 cggccgcgac cacgacctcg ccgatccggc ggtggaacac cagccgcagc ccggacgccg
    12121 tgccctggac gcggcaccgc ccgccgagcg acgcggcgag gtggaagctg cccggcagcc
    12181 tgcgggcgag ctcgtcgagg tgggtgaggt cgcgcaggcc ggcggccgcg cgttccagtt
    12241 ccgcgacgct gaccgggcac cagccgatca ccgccagccg ggcgtcaccc gctgccgcgg
    12301 cgacgatctc gtcgtcgcgc caccggccgg cgagccacgg acgtcccgac gcgtgctgca
    12361 gcgatcggaa ccccggcgca cacaagcgac gggccacggc gagcgcggct tcgtggtcgg
    12421 gtaggaccac gaagtgcgac tcgccgtgac cccgcgaggc ctgatcaggc attcgcggtg
    12481 gtgtcgcgtc agttcttgct gaagatcagc cggtcgttgc cgttcctctg gagcaggccc
    12541 gtctgcgctt cgaaggtgcc caggtcgatc agctgcggcg tctcgtacat ggttctgcct
    12601 ctctcgttga gggatcttca tggcagcgcg ctgaatcgaa cgtaacgaga gggctggacc
    12661 ggcgaccagg caaaacggct tccggttccg gcaactgccg caaccggaaa accaggttta
    12721 ggagaggtgt tcgaggagaa gggagctcgc cgcctccggg atctcctcgg gaatccagtg
    12781 gctcacgtcc tcgaccatct cgaaccggta gggcccggtg caccacttct cggtctcgaa
    12841 cgcggccacc gatccgaacg cgacgtcctc ggtgctccag acgtacatcg tcttgacggc
    12901 caccttgtct gcggtgccgg acggcttgcc cgcgcggtac cagttcaagg cggccgagag
    12961 cgcgcccggc tcggacaggc gctggatgta ctcgtccacg tgcgacggcc ggatccggta
    13021 ctcgaacatc tgccgcaggg cgtgcgcgtt gttctccagc atgcggcgct cggtgctgcg
    13081 ttcgcgccag tcgagcatgt actgggaccg catccgctgc tcttcgtcgg tctgcagcgc
    13141 ggtcttcagc gcgccggggt gcggcgtgga gaacacgctc aacgtgcgga gacgatccgg
    13201 gtggtcgatc gccgtccacc acgcgacagc gccaccccag tcgtgcccga cgaggtcgaa
    13261 ggtggaccag ccctgcgcgt cggccatcgc gatcacgtcg ccgacgaggt gcgtgaccgt
    13321 gtactcggag gactgctccg ggcggactcc gggggagtag ccgcgctggt cgggggcgac
    13381 ggcgcggaag ccgttcgcgc cgagcaccgc cacctggtgc tcccactcga tggcggcttc
    13441 ggggaagccg tgcagcagca ggaccgggcg gccgtcctct ggaccggacg cgatggcgtc
    13501 gaaggtgcct gcctcggtct cgatgctcag gtggtcgatc acgagttcga acagtaccgg
    13561 cgtgacctga cgctcaaccg gcgagccgcg ctggaccggg cgaggtccgc gggtctccac
    13621 gatcgggtga tggtcgagtc gagggactac tgagaggagc acggtcagtg cgacgccgtc
    13681 gtgagcgcct cggtgatcga ggcagtcagt gccgactatt ggccggcgta cttctcggtg
    13741 cgcggccaca ccccgctgcg gaccgccggg acgtggtcgt tcgggcacga ctgagccgag
    13801 acccccgaag cggtggcggc acaccttcct cacccgttcg gacgaggtga cacagctcgg
    13861 cttcgacgac gcgttccgcc ggatgcagga gttccacccg gcctgctcgg aggccggttc
    13921 cggggtcgct acctcggaaa tctgcaattc gcaatggccg aaagactggg ccattaggac
    13981 caccttctac cccaaaaggg tgctgcttgc cccacccgcc tggacttcgt ggtcctcttg
    14041 gagacaggcg gtatcagacg gctcgctgcg gtctcttctt ctgtgaagcc cctagtgtcg
    14101 ctgtagtgga ggaggtcgcc gggatggtcc aacccacagc cgtgcggacc ggtggcggtg
    14161 tcggcgtcct cgatccagag gaggtgtgga accagccaac ggtgcccatg cgtcgtcggg
    14221 tgcgccaggc accggtctcc aaccagtggc tcgccgaagc cgagttcacc gacctcgtcg
    14281 acgccgctct agacggagac agacgggcgg tcgagcacct gctcggccgg atccagccgt
    14341 tgatcgtgag gtactgccgc gccagggttg gtggccgtga gcgcaccctc gtctcggccg
    14401 aggacatcgc gcaggaggtc tgcgtcgcgg tgctcggtgc cctgtccaag taccgctacg
    14461 agccgcagtc gttcctcgcg ttcgtctacg gcatcgccgc ccacaaggtc gccgacgccc
    14521 gtcgccgcgc cgtccgcaac cgcgccgagg tcgtgccgga gctgcccgac tgcccgtcgc
    14581 tcgacgacgg cccggagcag cacgcggtca acggcgagat gatggcccag gtcacgcgcc
    14641 tgctgcacaa gctgccggca cgtcagcgcg agatcctggt gctgcgcgtg gcggtggggc
    14701 tgtccgcgga ggaggtcgcg ctggccgtgg agtcgacgcc gggtgcggtg cgggtggcac
    14761 agcaccgtgc gctcacccgg atgcgggaga tgatcgccga ggagggctga gaatcgtttc
    14821 tcccaccgtg cgcgccacga acgccgcgta ggcgtcgccc ggtttgccgt ccagccggac
    14881 gaaccgcacg tacgcctcga cgctggtgat cacgcagaag gcttcgacga ggtcgtcgaa
    14941 gggcacgtcc gcgcgcagcc agccgcgttc ggcgaagacg tggaagacgt gttcgacctg
    15001 tcgtcgcagc agggcgaggt tggcggcgta atacccgcga agctcctcgt cgccctgcgc
    15061 cgcgctggct accgccaccc agaggcctgc cgacggagcg ttgatcgcga gcatcgcgtc
    15121 cccgatcagc gtggcgagct cagcggtgcc gctcacctgc agcatggcct ttcccaagtc
    15181 ggtggcgagc aggtcggtct caccctcgac cccgaaggac acgagctcca gcgcggcctg
    15241 cagcagcgcc gacttggggc cgtgacgctg cacggtctcg acggacacac ccgcctcggt
    15301 cgcgagctgg gcgaacgtcg tggcctggta gccctgccgg ctgaagagct ccgccgccgc
    15361 ttcgaccact cttcgccgcg tttccgctgc ctgccgctgt cgcagctcgg accggtaggg
    15421 gcgggtggat tcggtcatgt ccgacattat tgactacggt cccatgcagg ttaatactcc
    15481 gtgacagtct tcaacactgc tcccaatgtc ctaggcgggt gacgtcatgg cgtccctcat
    15541 catcgcgacg gtgcccgtcc acgggcatgt cacgccactt ctggccgtag cccgctattt
    15601 cacccagcgg ggagatcgcg tccggttcat cacgggcgcc cgtttcgccg aggtggtgga
    15661 ggccgcgggc gcggagcaca tcgcactgcc cgcagaagcc gacttcgacg accggcagga
    15721 cttcggggtg acgttccccg agcgcacagc gctcaagggg gcgaaggcga tcgcgttcga
    15781 cctggagaac gtcttcgtgc gccccggtcg cgcccactac aaggtgatcg aggcggcgca
    15841 gtcggccgag ccggccgacg tcgtgatcac cgagccggcg ttcctcggcg gcgcgttcct
    15901 cgtctgccgg ccgctcggcg agcggccacc ggtggtcgtg tgcggtgtgc tcccgctccc
    15961 gatctccagc cgtgacacgg cgccgtacgg catgggcctg accccgctgc gcggacctct
    16021 cggtcgcctg cgcaacgccc tgctcaccac gatcgccgcg cgcacggtct tcaccgcggc
    16081 cgagcggctg gcccaggaga tcaaccacaa gctgaacggg tccccgctgc cgttcccgat
    16141 catggactgg ctccggcacg ccgaggcgat cgtgcagttc accgtgcccg agttcgagta
    16201 cccgcgctcc gacgcacccg ccaccctgca cttcgccggc cccatctcgg cctccggttc
    16261 gcaggcgccg ttgccgtcct ggtgggacga actcgacggc tcgcggccgg tcgtccacgt
    16321 cacgcagggc acggtcgcca accacgacta ccggcagatc atcgaaccca ccctcgcggc
    16381 tctcgccgat gatgacgtcc tcgtcgtcgt gtccaccggg ggccggccgc tctccatcct
    16441 tccgccgttg ccgtcgaacg ctcgtgccgc tgagtacctt ccctacgacg aactcctgcc
    16501 gaagacgcag gtctacgtca ccaacggtgg ctacggtggc gtccagtacg ccctccgcca
    16561 cggcgtcccg atcgtcacga gtggcggtaa agaggacaag ccggaggtcg ccggccgagt
    16621 tgcgtggtcc ggtgtcggtc gtgcgctcag gaccgagacg ccctcgcctg ctgccgtcgg
    16681 gcgggcggtt cgcgctgtgc tcggcgatcc gcgctaccgg gcacgcgccc gacggatcgc
    16741 cgcgagcatg gagcgtgccg gtggactgcc ccggctcgcc gagatcgtcg accggcagct
    16801 ctcaggtcgc cggtcgtagc gttcgaggca tgacccgctt cgaggtgatc accggtatcg
    16861 cggccccgcc gcaccgcgtg ttcgatctca gcctcgacgt cgacgtgcac accgcctcga
    16921 tggccggctc cggtgagcgg atcgtcggtg gcatcagctc tggccggatg gggctgggtg
    16981 acaccgtgac gtggcaggcc ggtcacttcg gtgtgcgctg gcggatgacc tcgtgcatca
    17041 cggcactcga ccggccgcac cacttcgtcg acgagcaggt cgcgggtccg ttccggcgct
    17101 ggcaccacgc ccatcacttc gagccggacg ggcggggcgg cacgcgcatg cgggacgtcg
    17161 tcgagttcgc cgcgccactc agtccgctcg ggcgcctcgc tgaacgtctc gtgctcgacc
    17221 ggtacatggc cgagctcatc cggcagcgca acgaccacct caggacagtt gcggagctgg
    17281 cgcccggaga tccgtgaact ccgccaccag ggccgtgacc aggatcagcg cgccgaacac
    17341 gagcagcgcg agcgctccac ccgcgaggtc ggcgaggaac gcgccgagca ccggtgcgag
    17401 cggcgtgagc gctcgcgagg cgaaggtcag gatcgcgtcg atccgcccca tcaggtcgtc
    17461 gggcaccagc cctgtgaaga tcgcgctcac cgagacgttg agcaacggtg tcgcgatcgc
    17521 ggtgaccatg agcggcacga acggccacca cgcgccgaac ggcagtgcca tcgccaggtt
    17581 gctcacgccg aagaccgtga gcaccgcgac gatgagccgg tcgtacctca gggtgacctt
    17641 gggtgagatc agtgccccga gcagaccgcc gacgccgacg ccggtgagca ccaggccgac
    17701 gagccagtcc gggccgccgc gttccttgac cacggcgacg accgggatca tcgaggccgt
    17761 cccgagcagg ttgagcgtca ggaagatcgc cacgacgttg cgcatcccgc gccggcgcca
    17821 cagccaggtc caggcctcgc ggacgtcgtg gcgcacgcgc ccgcgcggcc gctgctcggt
    17881 gcgggccggg atcttggcga accaggcgca gacggcggcg acgaggaacg tcacggcgtc
    17941 cgcggcgaac gggacagcgc ggccgaaccc gtagagcagc gcgccgagcg acgggccggc
    18001 gagccacgcc acgtgaccgc gtgcctcctc ctgggcgaag gcggtcctga gccggtccgg
    18061 gggcacgacc gccttgatcg cggtggagcg ggcgggaccg gcgaacgcgg tgcagacgcc
    18121 gtccacggcg gccagcgcga tgaacagcgg gatcgagttg aggccggtga cgacgttggc
    18181 cgccatcgcc gcgacggcca cggcctgcgt cgtctggctc cagaccagga ccttgccgcg
    18241 gtcccagcgg tcgacccaca cgcccgccgg catctgggtg aggatcagtg tcgtggcgcg
    18301 cacgcccgcg atgacgccgg cccagaagaa cgacccggtg accgcgagga tcagcagggg
    18361 catcgcgtac gtcgtgagct gtgtgcccag ctgcgagacc gtcccgccca accagagcag
    18421 ctggaactga acgttcttcc tgagcggaac ccccatggac gacgtttcta gcgcatggtt
    18481 gccggtgtcg gatggcaagg tttgtgccat ggctgatccg gacttcgacg tgctgctcac
    18541 cggcacggtc ttcctcgaca tcatcttcac cggcctgccg cgcccgccgg ccgcggggac
    18601 agaggtgtgg gcggaggggc tcgggtcgtg tccgggaggg atcgcgaacc tcgcggtggc
    18661 gttgcgcagg ctggagctcc ggaccgcgct ggcggcggcg ttcggtgagg acgcgtacgg
    18721 cgacttctgc tgggacgtgc tgtccgaaca ggaaggggtc gacctttctt attgccggcg
    18781 tttctacggg tggcactcgc cggtgactgt gtccatggcg atggagcggg accgttcgat
    18841 ggtcacgcac ggccacgagg cgcccgtgat cgcggacgat ctcttctgcc cgccgccgtc
    18901 gacgcgggcg tgcttcgtgc acatccaggc cgaggacgag cagtgggtgc gcacggctaa
    18961 ggagaacggc gcgctgctct tcgccgacat cggctgggac cgcaccgggg cgtggtcgcc
    19021 ggagttgctg cggcggctgg agggatatga cgtgttcctc ccgaatcacg tggaggcgca
    19081 ggggtacacg cgcaccgact cgccggaggc cgcggcgcgc aagctttccg agcacgtgcc
    19141 ggtggtggtg gtcacacgcg ggggaggtgg cgcggtcgcg gtcgacagct ctaccggtga
    19201 ggtcgcggac gtgccggggc tgaacgtcgc gcagctcgac ccgacgggag ccggtgacgt
    19261 gtttggcgcc gggttcgtga tgggcactct ggccgggtgg ccgctggaac acagggtgcg
    19321 gttcgcgaac ctgtgcgccg cgctgtccgt gcagcacttc ggcggttccc tgtcggctcc
    19381 cggctgggga gacatcgcgg tctggtggcg gacggtgagc aggaggccgg acgaggagct
    19441 ggcgcggtac gggttcctcg acgacgtgct gcccgaccac gcgggcgtgg aggtgcgaag
    19501 ggctagtccg acgatcggcc tccggttgct ccggtaggtt gaaatcagtc gatcagcgga
    19561 cgcaacctca cgggcctccc gcgcgactta taagtaggga tctctggggt gttgctcgga
    19621 aggagttgcg ggtttgttcg ccgcacgcgc gtcaggcttg gtcaaattgc tggggttgtg
    19681 cctgacggcg ggcgtgctcc tcgctgcgat ggtgttcccg ttcgtcggag gtctcgggct
    19741 cgcgtccaac cgcgctgccg acaccgtcga ccagacgtcg ggtgacctcg ccaaggggga
    19801 gctgcctctc gtcacgacca ttcaggacat gaacggcgac ccgatcgcct atctgtacga
    19861 ccagtaccgc atcccgctgg cgtcgagcga catctcggac accatgaagg ccgcgatcct
    19921 ggcgatcgag gacaagcggt tctacgacca ccgcggcgtc gactggcaag gcatcgcccg
    19981 tgccgccgcc aaggccggtg tggacggtgg cgcgacgcag ggcgcttcga cgctgacgca
    20041 gcagtacgtc aagaactaca tggcgttcgt gctcggcgcc gacaacgagc aggaagcctg
    20101 ggagaaggcc accgaggcga ccatcggccg caagatgcgc gaggcgcggg tcgccttgca
    20161 gctcgagcag cagatgtcga aggaagagat cctcaccggc tacctgaaca tcgtgccgct
    20221 gggcaaccag acctacggcg tcggcgccgc ggccaaggcc tacttcaaga cgaccgccga
    20281 caagctgacc gtcccgcagg ccgcactgct ggccgcgatc gcgaaccgcc cgtcgtcgct
    20341 caaccccggc gcctcgccgg agaaggcgct ggagcgtcgc aacatcgtca tcgacaagat
    20401 gcgcgagaac ggcgcgttcg gtaccgacca gaccgaggct cagaagaagg ccgaggagta
    20461 caaggccgcg ccgctgggcg tggtcgacga cctgcagatc ctgcccaagg gctgcgtcgg
    20521 cgccggtgac ggtccgatct acggcttctt ctgctcctac ctgctcgact acctccgcga
    20581 gtccggcatc acgaacaagg aactgcagcg cggcggcctc accatcaaga cgacgatgga
    20641 cccgaaggcc accaaggcgg cgaagacgtc ggccgagcag caggtcccga agacccagaa
    20701 cggcatctcg aacgtcatgt cggtcgtcga gccgggcaag gacaagcacc gcgtgcgcgc
    20761 cctcgtcgcc tcccgcgact acggcaacaa ggccgagctc ggccaggtcg cgcgccccgt
    20821 gcccgccgag gtcctcccgt tcggccccgg ctcggtgaac aaggtcttca ccgccgccgc
    20881 ggccctggag aagaacgtca tcggcatcga caaggagatg gcggtcccga aggtctacta
    20941 ctcgagggtc taccccaacg gcggcgcgcc gtggaaggtc gagaacgccg gcacctacgg
    21001 cgagaagatg tcgctgaccc aggccctggc gcagtcgccg aacaccggct tcgtgatcct
    21061 gcaggagaag accggcctcg acagcgtcgt ggacatggcc taccgcctcg gcatgcgcga
    21121 aaccctccaa ggcgtcaacc gcgcgggcga accgctgaag gacgacaagt ccaacggccc
    21181 gtcccagggc gactggacga agcagaacaa cgcgggctcc tacaccctcg gccccggcgc
    21241 caccagcgtc ctcgaactgg ccaacgtcgc cgccaccatc gtctccggcg gcacctggtg
    21301 cccgccgtcc ccggtggaga aggtcatcga ccgctacggc aaggaagtcc cgctcaagga
    21361 aaagccctgc gagcaggccg tgaacaccga actggccaac tccctggccc agggcatgtc
    21421 ccacgacacc accggccagg gcaccgcggc ccaggcggcc tccggctccg gctggaaccg
    21481 cccgaccatc ggcaagaccg gcaccaccga agagcacaag tccgtcgcct tcatggccgc
    21541 caccccgcag tacgcgggcg ctgtcatgac ctacgccgac ggcaaccgcc ccgaggtgat
    21601 ctgcgccaac ccgatccggt tctgcccggg cagcaaccag ggcgtctacg gcggccaggt
    21661 agcggctccg acgtggttca acgcgatgaa ggtgatccac gagggcctgc cggtggtgcc
    21721 gctgccacca gcggccgcgc ggtacaagta gagcctgatt gattgcgggg ccgtcggacg
    21781 ccagatgcgt ccgacggccc tttgctctgt ccaggtggtg agtgggtggc gcttggcagg
    21841 gtcgcgcacc ccgctggcgg cgcgctgggt gggagctgtg gcgggtggag ggcgcccgtt
    21901 gggcggtgcg cacgccgctg tggcgttgtt gacgcaacca aagctcggta acggcccgcg
    21961 cgccacctgc tcaaggggag ccgacgcaca gcacgaaccc tcgctggaac agccgccagc
    22021 cgctccgcgc aaccaccccg caccaagcgc gcgccccaaa ggcgaccccg caaccagcca
    22081 agcacgcctc gtaaccacgt agctgcggtc acccagccaa accccgccgc aaagctttca
    22141 cgataaagcg actgaccagt acaaacacca agaacgggat tggtctaaag cctgttattc
    22201 aaacccacca cgactcaact acggtgtgtt accaatcgtg gccctcatca cctaaacgcc
    22261 cacttagctt gctcctgccg gtgacgcgag gttacgttca ccgccgcatg tcacggttcg
    22321 ataaccgcaa ggacacggat ctcccccgaa acggtccagt ccgacagggc ctccccagcc
    22381 cgccgcagag caccaacacg ccctgcacca cgcccggccc cgaagccgag gcacaccagc
    22441 ggttagccga actcccccga gtgcatggag gc
//
