LOCUS       NZ_CP029361            10885 bp    DNA     linear   CON 31-MAY-2024
DEFINITION  Streptomyces globisporus strain TFH56 chromosome, complete genome.
ACCESSION   NZ_CP029361
VERSION     NZ_CP029361.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globisporus
  ORGANISM  Streptomyces globisporus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7488586)
  AUTHORS   Cho,G.
  TITLE     Complete genome sequence of Streptomyces globisporus TFH56 isolated
            from tomato flower
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7488586)
  AUTHORS   Cho,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAY-2018) Division of Applied Life Science, Gyeongsang
            National University, Jinjudaero, Jinju 52828, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 29-MAR-2018
            Assembly Method :: canu v. 1.7; arrow polish v. SMRT link 5.1.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 37.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003147545.1-RS_2024_05_31
            Annotation Date                   :: 05/31/2024 02:17:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,917
            CDSs (total)                      :: 6,829
            Genes (coding)                    :: 6,492
            CDSs (with protein)               :: 6,492
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 337
            CDSs (without protein)            :: 337
            Pseudo Genes (ambiguous residues) :: 0 of 337
            Pseudo Genes (frameshifted)       :: 240 of 337
            Pseudo Genes (incomplete)         :: 121 of 337
            Pseudo Genes (internal stop)      :: 7 of 337
            Pseudo Genes (multiple problems)  :: 31 of 337
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:15:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7380965
            Orig. end                         :: 7391850
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029361.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10885
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="29"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10885
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10885
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5885](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5885
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    448..466
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.27"
                     /tool="antismash"
     misc_feature    complement(453..471)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 28.9"
                     /tool="antismash"
     gene            complement(463..1404)
                     /locus_tag="DIJ69_RS33285"
                     /old_locus_tag="DIJ69_33290"
     CDS             complement(463..1404)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060648.1"
                     /locus_tag="DIJ69_RS33285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33290"
                     /product="LysR family transcriptional regulator ArgP"
                     /protein_id="WP_044373571.1"
                     /transl_table=11
                     /translation="MMSEFPLDQVRTLLAVVDEGTFDAAANVLRLTPSAVSQRVKALEQ
                     RTGRVLLMRTKPVRPTESGEVVVRFARQLARLERDARTALGMSGPGEPTLLSIAVNSDS
                     LATWFLPALRRVPQELDLAYELHREDQDHTATLLREGLVMAAVTSSPEAVTGCSVRRLG
                     RMRYLPVAEPGFADRWLGRRAGTDVRELIEDAPVVSFDRRDDLQDSFVRRLVPGARASS
                     RRHLVPSSEGFASAVAAGMGWGMVPDVQAEPLLGDGRLVLLTPDRTVDVPLHWQQWKLD
                     SPALATVAEAVAAEAADTLAGGRPIAPRPLRG"
     gene            1472..2083
                     /locus_tag="DIJ69_RS33290"
                     /old_locus_tag="DIJ69_33295"
     CDS             1472..2083
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007459226.1"
                     /locus_tag="DIJ69_RS33290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33295"
                     /product="LysE family transporter"
                     /protein_id="WP_030809319.1"
                     /transl_table=11
                     /translation="MTNALTTAAAGFGTGLSLIVAIGAQNALVLRQGVRRDGVLAVVGI
                     CALSDAVLITLGVAGVGAVVVAWPSALTVVGLLGGLFLIGYGLLAARRVLRPSALHASD
                     APAASRRGVVLTCLAMTWLNPHVYLDTVFLLGSVAADQGPLRWTFGLGAILASLCWFAA
                     LGYGARLLSGVLARPSAWRVLDGLVAVMMIGLGTKLALGA"
     gene            complement(2136..3086)
                     /locus_tag="DIJ69_RS33295"
                     /old_locus_tag="DIJ69_33300"
     CDS             complement(2136..3086)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (26-313). E-value: 5.5e-53.
                     Score: 172.1. Matches aSDomain:
                     nrpspksdomains_DIJ69_RS33295_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060646.1"
                     /locus_tag="DIJ69_RS33295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33300"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_234876152.1"
                     /sec_met_domain="ADH_N (E-value: 5.6e-08, bitscore: 31.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.6e-16, bitscore:
                     57.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKNESMRAISQNVYGGPEVLEEVRLPRPVAGPSQIVVAVRAAGV
                     NPTDWKHRGQAMFLDRLPLVLGWDVSGVVESVGFGVTLFKPGDEVFGMLPYPYGVGSHA
                     EFAVGPARAFAHKPEGVDHVQAAALPLAALTARQALVDTADVRPGQRVLIHAAAGGVGH
                     LAVQIAKSLGAYVIGTASAAKHDFVRGLGADEVIDYRTVDFGDAVSDVDMVLDPLSGET
                     RARSLDVLRPGGTLVSLLPGGDPAEAAKAAAREIRVENLLVEADHAGMTAIAGLVRAGE
                     LRAHVEAAFPLAEAAKAHALGETGRTTGKLVLVVS"
     aSDomain        complement(2148..3008)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DIJ69_RS33295_PKS_ER.1"
                     /evalue="5.50E-53"
                     /label="DIJ69_RS33295_PKS_ER.1"
                     /locus_tag="DIJ69_RS33295"
                     /protein_end="313"
                     /protein_start="26"
                     /score="172.1"
                     /tool="antismash"
                     /translation="PRPVAGPSQIVVAVRAAGVNPTDWKHRGQAMFLDRLPLVLGWDVS
                     GVVESVGFGVTLFKPGDEVFGMLPYPYGVGSHAEFAVGPARAFAHKPEGVDHVQAAALP
                     LAALTARQALVDTADVRPGQRVLIHAAAGGVGHLAVQIAKSLGAYVIGTASAAKHDFVR
                     GLGADEVIDYRTVDFGDAVSDVDMVLDPLSGETRARSLDVLRPGGTLVSLLPGGDPAEA
                     AKAAAREIRVENLLVEADHAGMTAIAGLVRAGELRAHVEAAFPLAEAAKAHALGETGRT
                     TGKLVL"
     CDS_motif       complement(2580..2642)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DIJ69_RS33295_0001"
                     /evalue="1.90E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="DIJ69_RS33295"
                     /protein_end="169"
                     /protein_start="148"
                     /score="26.6"
                     /tool="antismash"
                     /translation="GQRVLIHAAAGGVGHLAVQIA"
     gene            3156..4121
                     /locus_tag="DIJ69_RS33300"
                     /old_locus_tag="DIJ69_33305"
     CDS             3156..4121
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060643.1"
                     /locus_tag="DIJ69_RS33300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33305"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_044373569.1"
                     /transl_table=11
                     /translation="MGNVHRVVVLALDGVYPFELGIPSRVLDAADGRYSVVTCTVDGRP
                     VRTNADFSVTVEHGPEALATADTLVIPPFDTSLLTREAPAHAVGALAAVRPGTRIVSIC
                     TGAFLLASAGLLDGRRATTHWALAELFRSWYPQVLLDPDVLFVDDGDVLTSAGAASGVD
                     VCLHLVRADHGSEVANRVARLCVVPPWRDGGQAQYIEQPVPDPAANGTAATRDWALRNL
                     HEPLSLASLADHARMSLRTFVRRFNEEVGMSPGRWIVQQRVDRARHLLESTDLAVDEIA
                     GRVGFATGASLRQHLHAAIGVTPLAYRRTFRGAVLAAGRP"
     gene            complement(4145..4783)
                     /locus_tag="DIJ69_RS33305"
                     /old_locus_tag="DIJ69_33310"
     CDS             complement(4145..4783)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060641.1"
                     /locus_tag="DIJ69_RS33305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33310"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_044373567.1"
                     /transl_table=11
                     /translation="MAKQDRAIRTRQAILMAAAQAFEKYGYQAATITEILKSADVTKGA
                     LYFHFPSKEDLALGVLDAQEPPQTVPEHSLKLQELIDLGMLFSHRLQTSLLARAGVRLS
                     MDQQAQGLDRSGPFLRWQEATHHLLAQAKHNGELLPHVNPTETADLYVAAFTGTQAVSQ
                     TLTNYRDLQRRHITLQQHILPSIAAPSILTALDLTAARAERLSRLAPED"
     gene            5001..5885
                     /locus_tag="DIJ69_RS33310"
                     /old_locus_tag="DIJ69_33315"
     CDS             5001..5885
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060639.1"
                     /locus_tag="DIJ69_RS33310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33315"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_274535715.1"
                     /sec_met_domain="AfsA (E-value: 4e-24, bitscore: 83.1,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHPVGIDMVHRTRPEDAFPRNWVRLAHDRFSVAAVLPHDHPFFA
                     PLGDRHDPLLVAEAMRQAAMLAFHAGYGVPLGYHFLMADLDYVCHQDHWGVGGVPTEID
                     VEVFCSDLKWRSGLPVQGRVGWAVHRDGELAATGMGATRFTSPKVYRRMRGDAPAEGIS
                     IPEAAPVAAAHAGRSRTEDVVLSDTGRDGVWELRVDTRHPTLFQRPNDHVPGMLLLEAA
                     RQAACLAAGPGGIVPAEASSRFHRYAEFGSPCWISAVILPEEAEDTVTVQVTGRQNDQP
                     VFSTLLSGPRADG"
     gene            5900..6748
                     /locus_tag="DIJ69_RS33315"
                     /old_locus_tag="DIJ69_33320"
     CDS             5900..6748
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382293.1"
                     /locus_tag="DIJ69_RS33315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33320"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_044373565.1"
                     /transl_table=11
                     /translation="MILVTGATGAVGREVAGLLAAAGPLRILARRPERLTVRGGGIEVV
                     EGAYGDRPALDRALRGVTSVFLVTNSPTEPDDERVAGAAAAAGVRHLVKLSMMAVEEPG
                     ADDFITRRQRRNEEAIRESGVPWTFVRPRTFMSNTLSWAPGIRSAGVVRALYGDAPVAC
                     VDPRDVAAVAVAVLTGAGHEGRAYAVSGPEAITAREQTAQLSRVLGRPLRFEELGPDAA
                     RTALLAKYPRPVAEAFLESAERQLAGAKAAVVPTVQEVTGHPARSYRTWAADHADAFAA
                     E"
     misc_feature    6842..6859
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     gene            6942..7652
                     /locus_tag="DIJ69_RS33320"
                     /old_locus_tag="DIJ69_33325"
     CDS             6942..7652
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606639.1"
                     /locus_tag="DIJ69_RS33320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33325"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_078955585.1"
                     /transl_table=11
                     /translation="MTKQERATRTRQALIRSAAAVFEQHGYAQARLALISSGAGVSTGA
                     LHFHFENKAAVAEAVMAEASQGLRDMSAAIRRRTDTALQALVDTSHALVEGLRGDPVSR
                     AGFRLSCDGGRAAAPDLRMEWHHRVRELLEEAAAAGTLADDITREDAAAATVAVTAGFE
                     VLGRHDAEWLSPYRLTGFWQLLLPRLATPETLVRVDPSGTATVPPARGPALAGRVVGEA
                     DLPAGATAVAAEAT"
     gene            7705..8448
                     /locus_tag="DIJ69_RS33325"
                     /old_locus_tag="DIJ69_33330"
     CDS             7705..8448
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060632.1"
                     /locus_tag="DIJ69_RS33325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33330"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_044373587.1"
                     /transl_table=11
                     /translation="MADEIFVNPRLAAVYDPLDPDRRDLDPYIRLAEELGARRVLDIGC
                     GTGVFALLLAERGIEVVGADPAQASVDVARAKPGGDQVRWICGDAAALPPLQVDLATMT
                     ANVAQEIVDQDDWQATLRGAYTALRPGGHLVFETRDPARRAWEAWNRESSYRVTEIPGA
                     GPVENWVDVTEVAGPLVSFRWTYVFAADGEVLTSDSTLRFRQRQEVEVDLGTAGFVVCE
                     VRDAPDRPGREFVFIARRPDPAEHR"
     gene            complement(8411..9340)
                     /locus_tag="DIJ69_RS33330"
                     /old_locus_tag="DIJ69_33335"
     CDS             complement(8411..9340)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007459219.1"
                     /locus_tag="DIJ69_RS33330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33335"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_030809296.1"
                     /transl_table=11
                     /translation="MDDQPEAAAPEPLDRRAELSEFLRTRRAKLQPQDVGLPEFGRARR
                     VPGLRREELAQLAGVSVAYYTRLEQGNGRNVSAEVLDAIARALRLTDAEHAHLNHLARP
                     ARHKKKRRPARVQRVRTGLLYLLDNMDGIPAYVTGARSDILAWNAMAAAVFGDWGALPP
                     GERNWARLVFLSPGYRDLFVNWDSKASDMVSYLRLYAGCHPDDPELSALVGELSVKSDE
                     FRRLWATHNVKEKGHGVKLVRHPLAGDLTLSYETLNLPDDEEQHLVTYHAEPGSESAQA
                     LRLLASWGSDAAGADVISGARRGPADER"
     misc_feature    complement(9425..9440)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.13"
                     /tool="antismash"
     gene            9503..10543
                     /locus_tag="DIJ69_RS33335"
                     /old_locus_tag="DIJ69_33340"
     CDS             9503..10543
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (19-269). E-value: 8.8e-13.
                     Score: 40.0. Matches aSDomain:
                     nrpspksdomains_DIJ69_RS33335_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761872.1"
                     /locus_tag="DIJ69_RS33335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_33340"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_030809293.1"
                     /sec_met_domain="ADH_N (E-value: 5.3e-28, bitscore: 95.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-22, bitscore:
                     78.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVAAYAAPRAKAPLERTTIERRPVGEFDILIDIKFAGICHSDI
                     HQARDGWGEGIFPMVPGHEIAGIVAETGSGVTRFKVGDRVGVGCMVDSCGRCDACLMGR
                     EQHCAEGNTQTYNALDRSGEPTYGGYSTHLVVTEKFAVSIPEGIALDEAAPLLCAGITT
                     YSPLKRWGAGPGKKVAVVGLGGLGHMAVKIAHALGAEVTVLSQSLRKKDDGLKLGADHY
                     YATSDPKTFEELAGTFDVILSTVSAPLDFGAYLGLLRTEGTLVNVGAPEEPISLNLFSL
                     ILGNRSIAGSAIGGIKETQEMLDFCAVHGLGAEIEVIEASQVNEAYERVLASDVRYRFV
                     IDTATI"
     aSDomain        9560..10309
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DIJ69_RS33335_PKS_ER.1"
                     /evalue="8.80E-13"
                     /label="DIJ69_RS33335_PKS_ER.1"
                     /locus_tag="DIJ69_RS33335"
                     /protein_end="269"
                     /protein_start="19"
                     /score="40.0"
                     /tool="antismash"
                     /translation="TIERRPVGEFDILIDIKFAGICHSDIHQARDGWGEGIFPMVPGHE
                     IAGIVAETGSGVTRFKVGDRVGVGCMVDSCGRCDACLMGREQHCAEGNTQTYNALDRSG
                     EPTYGGYSTHLVVTEKFAVSIPEGIALDEAAPLLCAGITTYSPLKRWGAGPGKKVAVVG
                     LGGLGHMAVKIAHALGAEVTVLSQSLRKKDDGLKLGADHYYATSDPKTFEELAGTFDVI
                     LSTVSAPLDFGAYLGLLRTEGTLVNVGA"
ORIGIN
        1 ccgaacaccg tgtcgaacgt ggtcccgccc gtgcggacgc tctcgtcgag caggtcccag
       61 ccccgcagca tgaccggatc ggtgaacatc cgggccatcg tggccatcga gccggccgtg
      121 ccggtgcgca ggaagtcgcc cgccgcggtg gtccggaaga ggcccggttc cgtctcggac
      181 agcagttgga gtccggccag ggcgcgcagc agacgcagcg tcgcctgcgg atgggtgccg
      241 agggacgcgg cgagcgcgtc ggcggtcagt tcgccggaac cgatccggtc gaagacgtcg
      301 aaccgcacgg ctgtgcccag ggcctgggtg gccatctggc cgagcacgag ccgggacaac
      361 gccccgcgcg cctgccaatc gaccggcgct tcctggccgt tgcgggtctc ctgatcctgg
      421 ccatccgtca tgttccgcac ctccctgttg ggttaggtga acctaacctc gaagggggcg
      481 aggggcaatc ggccgtccgc ccgcgagcgt gtcggcggcc tccgccgcca ccgcctcggc
      541 cacggtcgcc agggcgggtg agtccagctt ccactgctgc cagtgcagcg gcacgtccac
      601 ggtgcggtcc ggggtgagca gcaccagccg gccgtcgccc agcaacggct ccgcctggac
      661 gtcgggcacc atgccccagc ccatgcccgc cgccacggcg ctcgcgaacc cctccgagct
      721 gggcaccaga tgacgccggg aactcgcccg ggccccgggg acgagccggc gcacgaacga
      781 gtcctgcagg tcgtcgcgcc ggtcgaagct gaccaccggg gcgtcctcga tcagttcgcg
      841 cacatcggtg cccgcccgtc tccccagcca ccggtcggcg aagccgggtt cggccaccgg
      901 cagataccgc atccggccga gcctgcgcac cgagcacccc gtcaccgcct ccggtgacga
      961 ggtcaccgcg gccatcacca gcccttcccg cagcagggtg gccgtatggt cctggtcctc
     1021 ccggtgcagt tcgtaggcga ggtcgagctc ctgcggtacg cgccgcaggg cgggcaggaa
     1081 ccaggtcgcc agggaatcgg agttcaccgc gatcgacagg agcgtcggtt cgccgggccc
     1141 ggacatcccg agcgccgtcc gcgcgtcgcg ctccagccgg gcgagctggc gggcgaagcg
     1201 caccaccacc tcaccggact cggtcggccg caccggcttc gtacgcatca gcagcacccg
     1261 gcccgtgcgc tgctccagtg ccttcacccg ctggctgacc gccgacggtg tcagccgcag
     1321 gacgttcgcc gccgcgtcga aggtgccttc gtcgaccacg gccagcagcg tgcgcacctg
     1381 atcgagagga aactcggaca tcatggatgc taatgatacg taagaatctt tagctggacg
     1441 ccacaactct gtgctccgta gcgtcggccg catgacgaac gccctgacca ccgcggccgc
     1501 cggattcggt accggcctct ccctcatcgt cgccatcggc gcccagaacg ccctggtgct
     1561 gcgccagggg gtccgccggg acggcgtgct cgcggtggtc ggcatctgcg ccctgtccga
     1621 cgcggtcctc atcacgctgg gggtcgccgg cgtcggcgcg gtcgtcgtcg cctggccctc
     1681 ggcactgacc gtcgtgggcc tgctcggcgg cctgttcctg atcggctacg ggctgctcgc
     1741 cgcccgccgc gtactgcgcc cgtccgcgct gcacgcgtcg gacgccccgg ccgcgtcgcg
     1801 ccggggtgtc gtgctgacct gcctggcgat gacctggctc aacccgcacg tgtatctcga
     1861 caccgtgttc ctgctggggt ccgtcgccgc cgaccaggga cccctgcgct ggaccttcgg
     1921 cctcggcgcg atcctcgcca gcctgtgctg gttcgcggcg ctcggctacg gagcccggct
     1981 gctgagcgga gtccttgccc gcccctccgc gtggcgggtg ctggacggcc tggtcgccgt
     2041 gatgatgatc ggcctcggta cgaaactggc gctgggcgcc tgaacgcccg gccgcccgcc
     2101 ccgtacacgg agcgggcggc cgggcgcgcc gcgttctacg acaccacgag gacgagcttg
     2161 ccggtggtgc ggcccgtctc gcccagcgcg tgcgccttcg ccgcctcggc cagcgggaag
     2221 gccgcctcga catgggcgcg cagctcaccg gcccggacca ggccggcgat ggccgtcata
     2281 cccgcgtgat cggcctcgac cagcaggttc tccacccgga tctcccgtgc ggcggccttc
     2341 gccgcctccg ccgggtcgcc gcccggcagc agcgacacga gcgtgccgcc cgggcgcagg
     2401 acgtccagtg aacgcgcccg cgtctcgccc gagagcgggt cgagcaccat gtcgacatcg
     2461 ctcaccgcgt ccccgaagtc cacggtgcgg tagtcgatga cctcgtccgc cccgagcccg
     2521 cgcacgaaat cgtgcttggc ggcgctcgcg gtgccgatga cgtacgcccc cagcgacttg
     2581 gcgatctgca cggcgaggtg gccgaccccg cccgcggcgg cgtggatcag gacccgctgc
     2641 ccggggcgca cgtccgccgt gtcgacgagc gcctggcggg cggtgagcgc tgcgagcggg
     2701 agggccgccg cctggacgtg gtccacaccc tcgggcttgt gggcgaaggc acgggccggg
     2761 ccgaccgcga attcggcgtg ggagccgacg ccgtacgggt agggcagcat gccgaacacc
     2821 tcgtcgcccg gcttgaagag ggtcactccg aagcccaccg actcgacgac cccggacacg
     2881 tcccagccca ggacgagcgg cagccggtcc aggaacatcg cctggccccg gtgcttccag
     2941 tccgtggggt tcactccggc cgcgcggacg gcgaccacga tctgactcgg ccccgccacg
     3001 ggccggggga gccggacctc ctccagtacc tcggggcctc cgtagacgtt ctggctgatg
     3061 gcgcgcatgc tctcgttctt cgtcatacgt ccagcctcac gcctggccgc caggcgtacc
     3121 atggcatgat tgccatcttt cgacaggatc gtgccatggg aaacgtgcac cgcgtcgtcg
     3181 tactcgccct ggacggggtg tatccgttcg agctcggcat cccgagccgg gtcctcgacg
     3241 cggccgacgg tcgctactcc gtcgtgacct gcacggtgga cggccggccc gtgcgcacca
     3301 acgccgactt ctcggtcacc gtcgagcacg gcccggaggc gctggcgacg gccgacaccc
     3361 tcgtcatccc gcccttcgac acctcactcc tcacccgcga ggcgcccgcg catgccgtcg
     3421 gggcgctcgc ggccgtacgc cccggcaccc gcatcgtctc catctgcacc ggcgccttcc
     3481 tcctcgcctc ggccggactg ctggacggcc ggcgggccac cacccactgg gcgctcgcgg
     3541 agctcttccg gtcctggtac ccccaggtgc tgctggaccc ggacgtcctc ttcgtcgacg
     3601 acggggacgt gctgacctcg gccggcgcgg cgtccggggt cgacgtctgc ctgcacctcg
     3661 tccgcgcgga ccacggcagc gaggtcgcca accgggtggc ccggctctgc gtcgtaccgc
     3721 cgtggcgcga cggggggcag gcccagtaca tcgagcagcc cgtgcccgat ccggcggcga
     3781 acggcaccgc cgcgacccgc gactgggcac tgcggaacct ccacgaaccg ctgagcctgg
     3841 caagcctcgc cgaccacgcc cggatgagcc tgcgcacctt cgtccggcgc ttcaacgagg
     3901 aggtcggcat gagcccgggc cgctggatcg tccagcagcg ggtcgaccgg gcccggcatc
     3961 tcctggagtc cacggacctg gcggtggacg agatcgccgg ccgggtcggc ttcgccaccg
     4021 gagcctcgct gcgccagcac ctgcacgccg ccatcggcgt cactccactg gcctaccggc
     4081 gtacgttccg cggtgcggtc ctcgcggcgg ggcggccgta ggggtcggtc gggccccggc
     4141 cggttcagtc ctccggggcc aggcggctga ggcgttcggc gcgcgcggcg gtcagatcga
     4201 gggcggtgag gatcgagggc gcggcgatgc tgggaagtat gtgctgctgc agcgtgatgt
     4261 ggcggcgctg cagatcccgg tagttggtga gagtctggga tacggcctgg gtgcccgtga
     4321 atgcggcaac atacaggtcc gccgtctcgg tggggttcac gtgggggagc agctcaccgt
     4381 tgtgtttggc ctgcgcgagg aggtgatggg tggcttcctg ccagcggagg aaagggccgc
     4441 tgcggtcgag gccctgcgcc tgctggtcca tggagaggcg cacgcccgcc cgggcgagga
     4501 gactggtctg caggcggtgg ctgaacagca tccccagatc gatgagttcc tggagcttga
     4561 gggagtgctc cggaacggtc tgcggcggct cctgggcgtc gagaacaccg agcgcgagat
     4621 cttccttgga cggaaaatga aagtagagag cgcctttcgt gacgtcggcg cttttcagta
     4681 tttccgtgat cgtcgcggct tgatatccgt atttctcgaa agcctgcgcc gctgccatca
     4741 ggattgcctg gcgggtgcgg atcgcccggt cctgcttggc catcctgtct cctttgctag
     4801 gccggatggc ccgggaaacg gccgggacgg tatggggagg ggcggccctg ccggggatag
     4861 aaaaaaaacc gctgagtctg tatcttatca gcgcacgtgc atcgcaggaa cggctcgcca
     4921 tcacatgacc cctgggggga gttatgcccg aagcagcagc cctgatcgac tcggtgccgg
     4981 caatggattc ggaggccgac atggtgcatc ccgtggggat cgacatggtg caccggacca
     5041 ggccggagga cgcttttccg cgtaactggg tgcgccttgc gcacgatcgg ttctcggtgg
     5101 cggccgtcct gccgcacgat cacccgttct tcgccccgct cggcgaccgg cacgacccgc
     5161 tgctggtcgc cgaagcgatg cgccaggcgg ccatgctcgc cttccacgcc ggctacggcg
     5221 ttccgctcgg ctaccacttc ctgatggcgg acctcgacta cgtatgccac caggaccact
     5281 ggggcgtcgg cggagttccc accgagatag acgtcgaggt gttctgctcc gacctgaagt
     5341 ggcggagcgg actgcccgtg caggggcgcg tgggctgggc ggtgcaccgg gacggggagt
     5401 tggcggccac ggggatgggc gcgacccgct tcaccagccc taaggtgtac cggcggatgc
     5461 gcggcgacgc ccccgccgag gggatatcga taccggaggc ggcgccggtc gccgccgccc
     5521 atgccggccg gagccggacc gaggacgtgg tcctgtcgga caccggccgc gacggcgtct
     5581 gggagctgcg tgtggacacc cggcacccga cgctgttcca gcgtcccaac gaccatgtcc
     5641 cgggcatgct gctgctggag gcggcccgtc aggcggcctg cctcgcggcg gggcccggcg
     5701 gcatcgttcc ggcggaggcg agcagccggt tccaccggta cgccgagttc ggcagcccgt
     5761 gctggatcag cgcggtgatc ctgccggaag aggccgagga cacggtgacg gtccaggtga
     5821 caggccgtca gaatgaccag ccggtgttct ccacactcct gtccggcccg cgggccgacg
     5881 gctgagaggt tccacgccag tgattctcgt gacgggtgcg accggagcgg tgggccgcga
     5941 ggtcgccgga ctgctggcgg ctgccggtcc cctgcggatt ctcgcccgcc gtccggagcg
     6001 tctgacggta cgggggggcg ggatcgaggt ggtcgagggg gcgtacgggg accgccccgc
     6061 cctggaccgg gctctgcggg gggtcacctc cgtgttcctg gtgacgaaca gtcccacgga
     6121 gcccgacgac gagcgggtcg ccggggcagc cgccgcggcg ggcgtacgcc acctggtcaa
     6181 gctctccatg atggccgtgg aggagccggg cgccgacgac ttcatcaccc ggcggcagcg
     6241 gcggaacgaa gaggcgatca gggaatcggg ggttccgtgg acgttcgtcc gccccaggac
     6301 gttcatgtcc aacacgctgt cctgggcgcc cgggatccgc tcggcgggag tggtacgcgc
     6361 cctgtacggc gacgccccgg tcgcgtgcgt cgacccccgt gacgtcgccg cggtggccgt
     6421 cgccgtactc accggtgcgg gccacgaggg cagggcgtac gccgtctcgg gcccggaggc
     6481 gatcaccgcg cgggagcaga cggctcagct ctcccgggtg ctgggacggc cgttgcgctt
     6541 cgaggaactg ggcccggacg ccgcacgcac ggctctgctg gcgaagtacc cgaggcccgt
     6601 cgcggaagcc ttcctggaga gcgcggagcg gcagctggcg ggcgcgaagg cggccgtggt
     6661 gcccacggtc caggaggtga cgggacatcc ggcccggtcg taccgcacct gggcggccga
     6721 tcacgcggac gcgttcgcgg ccgaataagg tcgccgcccg ggatggggga ggcacgtcaa
     6781 ctccccgccg gaccacggaa aggtccgatc gcacacattc ccccatcccg gtctgtttcc
     6841 acagctcgca gagcggatat ggccgaaaaa agggcccggg agcctctggc gcaatcttcc
     6901 gttccctgga aatgaaaccg gtaagttggt ttgataactc catgaccaaa caggagcgcg
     6961 ccacccggac ccgccaggcg ctcatccgct ccgccgccgc cgtcttcgaa cagcacggct
     7021 atgcccaggc gcggctggcg ctgatcagct ccggcgcggg tgtcagcacg ggcgcgctgc
     7081 acttccactt cgagaacaag gccgcggtcg cggaagccgt gatggcagag gcgtcccaag
     7141 ggctgcgcga catgtccgcc gcgatccggc gcaggacgga caccgccctg caggcactcg
     7201 tcgacacctc gcacgccctc gtggaagggc tgcgcgggga cccggtgagc cgggccggat
     7261 tccggctgag ctgcgacggc ggacgggccg ccgcccccga cctgcggatg gagtggcacc
     7321 accgcgtgcg ggaactgctg gaggaggcgg ccgccgccgg aacactcgcc gacgacatca
     7381 cccgcgagga cgcggccgcc gcgaccgtcg cggtgacggc cggattcgag gtgctcggcc
     7441 gccacgacgc cgagtggctg tccccgtacc ggctcaccgg attctggcag ctgctgctgc
     7501 cccggctcgc caccccggag acgctcgtac gcgtggaccc gtccggcacg gccacggtgc
     7561 cgccggcccg gggacccgcg ctcgcgggac gtgtcgtggg cgaggcggac ctgccggcgg
     7621 gggcgacagc ggtggcggcc gaggccacct gaccgcaggc ggaggctggg gcgccggatg
     7681 gagcaccccg gtaccttcct ccgcatggca gacgagatct tcgtgaaccc gcgactggcc
     7741 gccgtctacg atccgctcga ccctgatcgc cgcgacctgg acccctacat ccgcctcgcg
     7801 gaagagctcg gggcgcgccg ggtgctggac atcggctgtg gcaccggggt gttcgccctg
     7861 ctgctggcgg aacgcgggat cgaagtcgtc ggcgccgacc ccgcacaggc gtcggtcgac
     7921 gtggcgcgcg ccaagcccgg cggcgaccag gtccgctgga tctgcgggga cgcggccgct
     7981 cttcccccgc tgcaggtgga cctggccacc atgacggcca acgtcgcaca ggaaatcgtc
     8041 gaccaggacg actggcaggc gaccctgcgc ggcgcgtaca cggccctacg gcccggcggg
     8101 catctggtct tcgagacacg ggacccggcc cggcgggcct gggaggcgtg gaaccgggag
     8161 agttcttacc gcgtcaccga gatccccggg gccggccccg tcgagaattg ggtcgacgtg
     8221 accgaggtcg ccgggccgct cgtctcgttc cgctggacct atgtgttcgc ggccgatgga
     8281 gaggtcctga cctccgactc caccctgcgc ttccgtcagc gtcaggaggt cgaagtggac
     8341 ctggggacag ccggattcgt ggtgtgcgag gtgcgcgacg cacccgaccg gccgggccgg
     8401 gagttcgtgt tcatcgctcg tcggccggac cccgccgagc accgctgatc acgtccgccc
     8461 cggcagcgtc ggatccccaa ctcgccagca gacgcagggc ctgggccgac tccgaacccg
     8521 gctccgcgtg ataggtcacc aagtgctgtt cctcgtcgtc cgggaggttc agcgtctcgt
     8581 acgacagggt caggtccccg gcgagcgggt gccggaccag cttgacgccg tgacctttct
     8641 ccttgacgtt gtgcgtggcc cacagccgcc ggaactcatc gctcttgacc gagagttcgc
     8701 cgaccagcgc cgacagctcc ggatcgtcgg ggtgacagcc cgcgtacaac cgcagatagc
     8761 tgaccatgtc cgaggccttg gagtcccagt tgacgaacag gtcccggtag ccgggggaga
     8821 ggaacaccag gcgcgcccag ttccgctcgc ccggcggcag cgcgccccag tcgccgaaca
     8881 ccgcggccgc catcgcattc caggccagga tgtccgagcg cgccccggtc acgtacgcgg
     8941 ggatcccgtc catgttgtcg aggagataca gcagcccggt ccgcacccgc tgcacccggg
     9001 ccgggcggcg cttcttcttg tgccgggccg gcctcgccag atggttcaga tgcgcgtgct
     9061 cggcgtcggt gagccgcagc gcacgcgcga tcgcgtccag cacctcggcc gacacgttgc
     9121 gcccgttgcc ctgctccagg cgcgtgtagt acgccacgga gaccccggcc agctgcgcca
     9181 gctcctcccg gcgcaggccc ggcacccgcc gggcccggcc gaactccggc agccccacgt
     9241 cctgcggctg gagcttggcc ctccgggtgc gcaggaactc gctgagttcg gcgcgccggt
     9301 ccagcggctc gggggcggcg gcctcgggct gatcgtccat accctccatt attcctggga
     9361 ttcccggtcg taggcgcccg agcctgtccc cgccagtagt aggaccgctg gacgtaggca
     9421 aagcggtgac ctgggtaaac atgtgcaggg gcggcaggct gggtgacgtt cctaccgcat
     9481 cacccagagg agaacctccg gcatgaccac cgttgccgcc tacgccgctc cccgtgccaa
     9541 ggccccgctg gagcgcacca cgatcgagcg tcgtccggtg ggcgagttcg acatcctgat
     9601 cgacatcaag ttcgccggaa tctgccactc cgacatccac caggcccgcg acggctgggg
     9661 cgagggcatc ttccccatgg tcccgggcca cgagatcgcc gggatcgtcg ccgagaccgg
     9721 ttccggggtc acccgcttca aggtcggtga ccgcgtcggc gtcggctgca tggtcgactc
     9781 ctgcggccgg tgcgacgcct gtctcatggg ccgcgagcag cactgcgccg aggggaacac
     9841 ccagacgtac aacgcgctcg accgcagcgg cgagcccacc tacggcggct actcgacaca
     9901 cctcgtcgtg accgagaagt tcgccgtctc catccccgag ggcatcgccc tcgacgaggc
     9961 cgccccgctc ctgtgcgcgg gcatcaccac gtactccccg ctcaagcgct ggggcgcggg
    10021 ccccggcaag aaggtcgccg tcgtcggcct cggcggcctc ggccacatgg ccgtcaagat
    10081 cgcgcacgcg ctcggtgccg aggtcaccgt cctctcccag tcgctgcgga agaaggacga
    10141 cgggctcaag ctgggcgccg accactacta cgcgaccagc gaccccaaga ccttcgagga
    10201 gctggccggt accttcgacg tcatcctctc cacggtctcg gccccgctgg acttcggcgc
    10261 ctacctcggc ctgctgcgca ccgagggcac cctggtcaac gtgggcgccc ccgaggagcc
    10321 gatctcgctg aacctcttct ccctgatcct gggcaaccgg tcgatcgcgg gttcggcgat
    10381 cggcgggatc aaggagaccc aggagatgtt ggacttctgc gccgtgcacg ggctcggcgc
    10441 cgagatcgag gtgatcgagg cgagccaggt caacgaggcg tacgagcggg ttctcgcgag
    10501 tgacgtccgc taccgcttcg tgatcgacac cgccaccatc tgacccgcgc tgaccctgcg
    10561 ccgaaggcgt ccgccccgag cacctcacgt gctcggggcg gacgccttcg gcggtcctcc
    10621 ctcgtcgcgc gcggggggcc cggcccggct gacaatggcg gaagacggcc gggcggaccg
    10681 cgccggaggg atcggccccg ggagaggagc gtgccggatg agcgcacagc ggcttctctc
    10741 gggcgggacc tcgcgggacg cacagcggct tctctcgggc gggacctcgc gggacgcaca
    10801 gcggcttctc tcgggcggga cctcgcgggg cgacgcacag cggcttcccc cggacgggac
    10861 ctggcgggac acaccacggc ttcct
//
