LOCUS       NZ_CP029361            10963 bp    DNA     linear   CON 31-MAY-2024
DEFINITION  Streptomyces globisporus strain TFH56 chromosome, complete genome.
ACCESSION   NZ_CP029361
VERSION     NZ_CP029361.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globisporus
  ORGANISM  Streptomyces globisporus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7488586)
  AUTHORS   Cho,G.
  TITLE     Complete genome sequence of Streptomyces globisporus TFH56 isolated
            from tomato flower
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7488586)
  AUTHORS   Cho,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAY-2018) Division of Applied Life Science, Gyeongsang
            National University, Jinjudaero, Jinju 52828, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 29-MAR-2018
            Assembly Method :: canu v. 1.7; arrow polish v. SMRT link 5.1.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 37.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003147545.1-RS_2024_05_31
            Annotation Date                   :: 05/31/2024 02:17:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,917
            CDSs (total)                      :: 6,829
            Genes (coding)                    :: 6,492
            CDSs (with protein)               :: 6,492
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 337
            CDSs (without protein)            :: 337
            Pseudo Genes (ambiguous residues) :: 0 of 337
            Pseudo Genes (frameshifted)       :: 240 of 337
            Pseudo Genes (incomplete)         :: 121 of 337
            Pseudo Genes (internal stop)      :: 7 of 337
            Pseudo Genes (multiple problems)  :: 31 of 337
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:15:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3052238
            Orig. end                         :: 3063201
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029361.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10963
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="16"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10963
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10963
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5963](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5963)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    633..647
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
     gene            752..1963
                     /locus_tag="DIJ69_RS13615"
                     /old_locus_tag="DIJ69_13615"
     CDS             752..1963
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191: acyl-CoA dehydrogenase type 2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016473234.1"
                     /locus_tag="DIJ69_RS13615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_13615"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_030799280.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.5e-06, bitscore:
                     26.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.9e-10, bitscore:
                     38.4, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTISQTTPTAAETERETLTAGTILARAEAAAPRLRELSEEIERGR
                     RLPEEAVRLVRGTGVFRIGMREEWGGPELTFSEQTRVIEALSYGDSAAGWCAMIGMDTW
                     IYAGYLDETVVKEMLADADAITAGLIFPVGRADRVPGGYRVTGRWPFGSGITHADWVVG
                     GCVVHSDGVPEPGEDGAPVNWRLMLVRREEVETVDTWHTHGLAGSGSTDYRVTDHFVPE
                     DRTFDFTTPRDSSPFSAPDAFLGNVPGVPLGVARAALDHVRELAAHRVERATDTPWSDS
                     YRVQTAIGEAEMQLSAARYAVYGSLDELWARLRDGVEATPDQQVAAALARLNAFRTARS
                     IVQRLSDLVGTASIYRTSPLDRWLRDLHTMCQHILAQEQIAQSAGAHLIGGTPQAPFPL
                     GLKG"
     gene            2056..3537
                     /locus_tag="DIJ69_RS13620"
                     /old_locus_tag="DIJ69_13620"
     CDS             2056..3537
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="DIJ69_RS13620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_13620"
                     /product="MFS transporter"
                     /protein_id="WP_078955529.1"
                     /transl_table=11
                     /translation="MATSGEVQVEPAGDKKVGADGTQKSWGLREWGLLVSVCAAFFLDA
                     LDNIMVGIAVPPIQADLGMSTAAVQWVVSSYVLGFGGFLLLGGRMADLIGRRRVFLVGV
                     AVFALGSLVGGVTNEGLVVIAARFVMGIGAAFTAPAALSIIITNFPAGPQRNRAVGIYT
                     ACGAVGYSTGVIVGGALTEINWRWTFLLPVVVAIAALVGGLTLVPRDNVADRARGSFDV
                     AGAVTVTSGMLLLVYAIVEAPNAGWLSGRTLLVFAAAVALLVAFTVIESRTAQPLLRLG
                     LLRNRSLVGASLVAAAILGTYMSFQFIGGLYLQTLRGWSPMEMALAFLPIGLLIATIAP
                     RSGKLISRFGVQWMIVAGFVAYTASYLLFLRIDESSGYLWVILPSILLIGIAFPFSFPA
                     ANVQATANVADEEQGLAAGVLQTGYQVGAAVVLAVVTATMAVDHTGGGEGAKTLDGYHS
                     GLWVLVAISAVTVVLTAIAAVRASARRKVSADVSV"
     misc_feature    3645..3657
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            3673..4905
                     /locus_tag="DIJ69_RS13625"
                     /old_locus_tag="DIJ69_13625"
     CDS             3673..4905
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385836.1"
                     /locus_tag="DIJ69_RS13625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_13625"
                     /product="cytochrome P450"
                     /protein_id="WP_030799283.1"
                     /sec_met_domain="p450 (E-value: 5.8e-19, bitscore: 66.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRTATCPFALDPQGRDIQGEIARIRARGPVVRVELPGGVHAWSV
                     THHATIKRLLLDPRVSKDAYRHWPAWTRGEIPPDWPLAIWVSVQNMVTAYGEEHTRLRR
                     PVAAAFTGRRVAALRPRVEETTRAVLDELAALPPDAPVDLRRHFAHPVPNRVMGELFGI
                     PEQSRDVIGTVIQGFFRTSATPDEARANGFALYSALAEVIAHKRDHPGDDLTSDLIAVR
                     DEDGGRLSEKELADNLILLFTAGYETTVNLLDQAVDALLRHPGQLALVRGGQAGWDDVI
                     DETLRYEAPGAHAILRYAVEDIGLDTVTIRKGDAIVISYAAAGRDPELHGADADVFDVT
                     RPTRKEHLSFGHGVHRCLGAPLARMEATVALDALFSRFPEMALADPERPAEPLASFISN
                     GHRELLVRLRP"
     gene            complement(5001..5963)
                     /locus_tag="DIJ69_RS13630"
                     /old_locus_tag="DIJ69_13630"
     CDS             complement(5001..5963)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041195.1"
                     /locus_tag="DIJ69_RS13630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_13630"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_162648878.1"
                     /sec_met_domain="AfsA (E-value: 1.2e-20, bitscore: 72.0,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSSAFREHLSASAPGDDPPQGPPTGAEGWETVPRELVHRLRADD
                     VLLTGWERVDDDRFRVSVRWPDRHDHFTPRRRQYPPQLVGETMRQATMLLAHTEYGVPL
                     EDQFLIRDLDYRLRPDRLGVGEGPARIDAEIVCSAVRRRRGRLVAMHCRMTACRGQEVV
                     AVAAGNVSITTAAVYRRLRHTRPPAELAAFAVPVAPERVGRTDPRHVVLAPTPQAERWQ
                     LRADPLNATLTGRARDHYSGLILMEAVYQAVLAGPGRRDFCPASFSIDFFRYADFAPPC
                     WIEAHTVPAATPGSTTVVVTGRQEGLTVFEASVGDARAF"
     misc_feature    complement(5295..5297)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6115..6804
                     /locus_tag="DIJ69_RS13635"
                     /old_locus_tag="DIJ69_13635"
     CDS             6115..6804
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523578.1"
                     /locus_tag="DIJ69_RS13635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_13635"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_030799286.1"
                     /transl_table=11
                     /translation="MAQQERARKTKDAILEAAGAVFAERGYDGATVSDVYSRAGLTKGA
                     FYFHFSSKKDLAEEVLSIQVDRQGYPILPRQVKLQELVDAGFVFAHRLMRDSMLQGSVN
                     LSLESGAHQLDRKRPFVAWIDHNQRALTEANDHGELYSHVDTAEVAELMVSSFSGAQIL
                     SHILTGRQDLTTRVAALLAHLLPTIAVPAVLARLDIAADRGERVLAEAGVGTTALRPAP
                     PGLTDTL"
     misc_feature    6864..6880
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 22.94"
                     /tool="antismash"
     misc_feature    complement(6865..6880)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.99"
                     /tool="antismash"
     misc_feature    complement(6867..6876)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.82"
                     /tool="antismash"
     gene            6927..7190
                     /locus_tag="DIJ69_RS13640"
                     /old_locus_tag="DIJ69_13640"
     CDS             6927..7190
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019981290.1"
                     /locus_tag="DIJ69_RS13640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_13640"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_030591399.1"
                     /transl_table=11
                     /translation="MNLHQLRTFCEVAGVHSFTKAARNLHYAQSTVTSQIQNLEDFLGA
                     PLFERGSRGIVLTDAGVRLLPYANAMLSLAESAHRHVARSPV"
     misc_feature    6942..6944
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7438..7974
                     /locus_tag="DIJ69_RS13645"
                     /old_locus_tag="DIJ69_13645"
     CDS             7438..7974
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013756.4"
                     /locus_tag="DIJ69_RS13645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_13645"
                     /product="flavin reductase family protein"
                     /protein_id="WP_044376364.1"
                     /transl_table=11
                     /translation="MGEVSATSRPVITIQDELRSVMRNFATGVCVVSTFTDAPSGRIHN
                     ALTVNSLTSLSLSPPLISISIRLESTFLDELMESGVWAVSVLDGGGEDLARIFARPEEE
                     RRRSLRSLPTEPGAATGAAVLDGAAWLECRYHQHVVTGDHVLVIGEVVGLGADSTRSPL
                     VFLHGGFHRFEREQV"
     gene            8020..9555
                     /locus_tag="DIJ69_RS13650"
                     /old_locus_tag="DIJ69_13650"
     CDS             8020..9555
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024846.4"
                     /locus_tag="DIJ69_RS13650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_13650"
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_078955687.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.6e-06, bitscore:
                     26.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAISIGVVGGGASAVCLIDALVMAKGGPGSLTVFEPSPNLWRGR
                     AYQVDSEIIKVNATPDDMSVRAGDPHHFIRWLGARERMLGESYGLDPFSGARFAPRTVY
                     GEYLEQTAYAGLAELRRQGWRVDLVGDSVTSARRTEDQVVVSTGRGMTSSFDYVVLCVG
                     GDGPKDVYGLAGSPGFIADPYPVSQNLRTIGAAERVAVIGSGLTAVDIVLSLAAQGHRG
                     PISLVSRRGVLPGVRQREAHFELRHLTQERMRALARSRREISVQEFTAIVHRELHDAGV
                     DLAALHTELASLDGESPADRLRRQFAAVNASDLGLRILQRAVPEIGPDVWPVLGEQDRA
                     EVLRLHYRTIMSLCCPMPPSSAAVLLGLIDEGRLDIRSGLDSASPGSGGGLTLSLLDGT
                     VLRTDRVINAVSASEGRIPQGAAPLVDTLVGGRAASLHPHGGLHVLRATSQLTTDGTSD
                     PRLYGLGTIAAGSLFFTFGVQSLVDRGVDIVDAILEHAAARTASHTAESLLPA"
     gene            9650..10495
                     /locus_tag="DIJ69_RS13655"
                     /old_locus_tag="DIJ69_13655"
     CDS             9650..10495
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016473237.1"
                     /locus_tag="DIJ69_RS13655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_13655"
                     /product="class II aldolase/adducin family protein"
                     /protein_id="WP_073775443.1"
                     /transl_table=11
                     /translation="MTTVSPLTHPHGTTSAATAPAGYLADTATGLPIPGEPDFATPEEA
                     RRHRKQRLAAALRLFGKYGFGEGISGHISVRDPEYPDQFWVNPFGVSFKHVRVADLICV
                     DSRGRVVHGKHRVNPSAFVIHSQIHELHPGATAAAHGHTAHSRALGAIGRLLDPIDQES
                     AAFYGRQTLYEAYEGPSVSLEQGRDIAEKLGDNRAILLRHHGLITVGGSLDEAVHWFFT
                     YDSCAQVQLLARAAGTPETFTHEQATAAGEGFGDEQLGWFSFQLLWDEIVAEQPDLLEE
                     "
ORIGIN
        1 ggacgtgtcg acgaagtgcc ggatgcagtc cggctgggcg caccggcgga tccggtccgg
       61 ggcggtgtcg aggagccgca ggtagtcgcg ggcggccagc caggccgcac cccaggaagg
      121 atcggcgaac tcggcctcct cgcccggccc ttccggggtc aggaccagcc ggacccggcc
      181 gtgctccagc acctcgtcga ggctcttggc ggcggcgggc gagcgggggt cggcgaagac
      241 cgcggcgatc gccgaccggg tccgtaccag cgcctcggcg gccggggcgt cggcggggaa
      301 gcggtcgccc aggccgtggc cgtcgagcca ggtccgcagg ccgggcaggg agtccagcag
      361 gtcgtgccgg cgcccgtcgg ccttccagag cgtgttcagc aggtcgacgg cgacaggttc
      421 gccgacgaac gggcgggggt cggtcagggc catggcgcat ccctccgtgc cgtaccgatg
      481 tgcactaacc cttcaagtgt acttgagcgg ttgcaaaccc tctctctaac ttctaaagtc
      541 acgtttgaca gttagccaag ggggagtgcc tggagctcac ggagaccgca cgcagacgtg
      601 tcagatcacg tgcgcgttca cgcgacagcc acggaccgac cgtccctaac gtgaggtagc
      661 gcggacgccg gaccacccgc gacgacatgc gcggcacggc accggagccg ttcgccgaga
      721 accggcaaca ggcacgcata ggaggctttc catgaccatc tctcagacca cgcccaccgc
      781 cgcggagacc gagcgggaaa ccctgaccgc cgggacgatc ctggcccgcg ccgaagccgc
      841 ggcaccgcga ctgcgcgaac tctccgagga gatcgagcgc ggccggcgcc tcccggagga
      901 agcggtccga ctggtgcgcg gaaccggcgt gttccggatc ggcatgcgcg aggagtgggg
      961 cggtcccgag ctgaccttct cggagcagac ccgggtgatc gaggcgctct cctacggtga
     1021 ctcggcggcg ggctggtgcg ccatgatcgg catggacacc tggatctacg ccggctacct
     1081 cgacgagacc gtggtcaagg agatgctggc cgacgccgac gcgataaccg ccgggctcat
     1141 cttcccggtc ggccgggcgg accgggtccc cggcggctac cgggtgacgg gccgctggcc
     1201 gttcggcagc ggcatcacgc acgccgactg ggtcgtcggc ggctgcgtcg tccacagcga
     1261 cggcgtcccg gagccgggcg aggacggcgc cccggtgaac tggcggctga tgctcgtacg
     1321 ccgcgaggag gtcgagaccg tcgacacctg gcacacccac ggcctggccg gcagcggcag
     1381 cacggactac cgggtgacgg accacttcgt ccccgaggac cgcaccttcg acttcaccac
     1441 cccccgcgac tccagcccgt tctccgcacc cgacgccttc ctcggcaacg tgccgggcgt
     1501 gccgctcggc gtggcccgtg ccgcgctcga ccacgtgcgg gagctcgccg cgcaccgcgt
     1561 ggagcgggcc accgacaccc cctggtccga cagctaccgc gtgcagaccg ccatcgggga
     1621 ggccgagatg cagctctccg cggcccgcta cgccgtctac ggatcgctcg acgagctgtg
     1681 ggcccggctg cgggacggcg tcgaggcgac ccccgaccag caggtcgccg ccgctctcgc
     1741 ccggctcaac gccttccgca cggcccggtc gatcgtgcag cgcctctccg acctcgtcgg
     1801 cacggcgtcc atctaccgga cctcgccgct ggatcgctgg ctgcgcgacc tgcacaccat
     1861 gtgccagcac atcctggcgc aggagcagat cgcccagtcc gcgggcgccc acctcatcgg
     1921 cggcaccccc caggcgccct tccctctcgg gctcaagggc tgaccccacc gcgacgagcg
     1981 cggccgggga cgaaggaacg accagcaccc cttgccggac cagccggcac ctcactcaag
     2041 gaatcaggaa agctgatggc aacttccggc gaagtacagg tcgagcccgc gggcgacaag
     2101 aaggtcggtg ccgacggcac ccagaaatcc tgggggctcc gcgagtgggg cctgctggtc
     2161 agcgtctgtg cggcgttctt cctggacgcc ctcgacaaca tcatggtcgg gatcgccgta
     2221 cccccgatcc aggccgatct cgggatgagc accgcggccg tgcagtgggt cgtgagctcc
     2281 tacgtcctcg gcttcggcgg cttcctgctg ctgggcggcc ggatggcgga cctcatcggc
     2341 cgccgccgcg tgttcctcgt cggcgtggcg gtcttcgccc tggggtcgct ggtcggcggg
     2401 gtgacgaacg agggcctggt ggtcatcgcc gcccggttcg tcatgggcat cggcgccgcg
     2461 ttcaccgcac cggccgcgct gtcgatcatc atcaccaact tccccgcggg cccgcagcgc
     2521 aaccgggcgg tcggcatcta caccgcctgc ggcgcggtcg gctactccac cggcgtcatc
     2581 gtcggcggag cgctgaccga gatcaactgg cgctggacct tcctgctgcc ggtcgtggtg
     2641 gcgatcgccg ccctggtcgg cgggctgacc ctggtaccgc gcgacaacgt cgccgaccgc
     2701 gcacggggct cgttcgacgt ggcgggcgcc gtcaccgtga cctccggcat gctgctcctc
     2761 gtctacgcga tcgtcgaggc gcccaacgcc ggctggctgt ccgggcgcac cctgctggtg
     2821 ttcgcggcgg cggtggcgct ccttgtggcc ttcaccgtca tcgagtcccg taccgcccag
     2881 ccgctgctgc gcctcggact gctgcgcaac cgctccctgg tcggggccag cctggtggcc
     2941 gcagcgatcc tcggcaccta catgagcttc cagttcatcg gcggtctgta cctccagacg
     3001 ctgcgcggct ggtccccgat ggagatggcc ctggccttcc tcccgatcgg gctgctcatc
     3061 gcgacgatcg cgccccggtc cggcaagctc atctccaggt tcggcgtgca gtggatgatc
     3121 gtcgcggggt tcgtcgcgta caccgcttcc tacctgctct tcctccgtat cgacgagagc
     3181 tccggctacc tctgggtgat cctgccgagc atcctcctca tcggcatcgc cttcccgttc
     3241 tccttcccgg ccgccaacgt ccaggcgacc gcgaacgtgg ccgacgagga acagggactg
     3301 gccgccggcg tcctgcagac cggctaccag gtcggcgccg ccgtggtgct cgccgtggtg
     3361 accgccacca tggccgtcga ccacaccggg ggcggcgaag gggccaagac gctcgacggc
     3421 taccacagcg gcctctgggt cctcgtggcc atttcggccg tcaccgtcgt cctcaccgcg
     3481 atcgccgcgg tccgggcctc cgcgcggcgc aaggtgtcgg cggacgtgag cgtctagatc
     3541 atcccgtccc ggcggcggac acccggggtg tcacccggtt cctcagggaa ccgggtgaca
     3601 ccccgctgcc gcgtgcgggc ggccgaccac ctcgcagcgg acccgtgccg ccgtcacgaa
     3661 caggagccga gcatgccccg taccgccacc tgccccttcg ccctcgatcc ccaaggacgc
     3721 gacatccagg gcgagatcgc ccgtatccgc gcccgcgggc ccgtggtccg cgtggaactg
     3781 cccggcggcg tccacgcctg gtcggtgacc caccacgcga cgatcaaacg cctgctgctg
     3841 gacccgcggg tctccaagga cgcctaccgg cactggccgg cctggacccg cggcgagatc
     3901 cccccggact ggccgctggc catctgggtg tccgtgcaga acatggtcac cgcctacggg
     3961 gaggagcaca cccggctccg gagacccgtg gcggccgcct tcaccggccg ccgtgtcgcc
     4021 gccctccgcc ccagggtaga ggagacgacc cgcgcggtcc tggacgagct ggccgccctg
     4081 cccccggacg cacccgtcga tctgcggcgc cacttcgcgc accccgtgcc caaccgtgtc
     4141 atgggcgaac tcttcggcat ccccgagcag tcgcgggacg tcatcggcac ggtcatccag
     4201 gggttcttcc ggacctcggc gacccccgat gaggcgcgcg ccaacggatt cgccctgtac
     4261 tccgccctgg ccgaagtcat cgcccacaag cgggaccacc ccggcgacga cctcaccagc
     4321 gacctcatcg cggtccggga cgaggacggc gggcggctca gcgagaagga actggcggac
     4381 aacctgatcc tcctgttcac cgccggctac gagacgacgg tcaacctcct cgaccaggcg
     4441 gtcgacgccc tgctgcgcca ccccggccaa ctcgccctgg tccgcggcgg acaggccggc
     4501 tgggacgacg tcatcgacga gaccctgcgg tacgaggcgc ccggcgcgca cgcgatcctg
     4561 cggtacgcgg tcgaggacat cggcctggac acggtgacga tccgcaaggg cgacgccatc
     4621 gtcatctcgt acgcggccgc gggccgggac cccgaactgc acggcgcgga cgccgatgtg
     4681 ttcgacgtga cccggcccac ccgcaaggag cacctctcct tcggccacgg ggtccaccgc
     4741 tgcctcggcg ccccgctggc gcgcatggag gcgacggtgg ccctcgacgc gctcttctcc
     4801 cgcttcccgg agatggccct ggccgacccg gagcggccgg ccgaaccgct ggcgtcgttc
     4861 atctccaacg gccaccgcga actcctggtc aggctgcggc cctgaggtcg caccggacgg
     4921 aacggacggg ctgcggcgta ggaacgccgg cctgctgccg ccggggcacc cgcgcccggc
     4981 ggcagcaggc cggccgtgcg tcagaacgcg cgggcgtcac cgacgctcgc ctcgaagacc
     5041 gtcagcccct cctgtcggcc ggtgaccacc accgtcgtcg atccgggcgt ggccgcgggc
     5101 acggtgtggg cctctatcca gcagggcggc gcgaagtccg cgtaccggaa gaagtcgatg
     5161 gagaaggagg ccgggcagaa gtcccggcgg ccgggcccgg ccagcaccgc ctggtacacg
     5221 gcctccatga ggatcaggcc cgagtagtga tcgcgcgcgc ggcccgtcag cgtcgcgttg
     5281 agcgggtccg cccgtaactg ccagcgctcg gcctgcggcg tcggagccag cacgacatgg
     5341 cgcgggtcgg tccggccgac ccgctcgggc gccaccggca cggcgaaggc ggccagttcg
     5401 gccggcggac gggtgtggcg gagccgccgg tagaccgccg cggtcgtgat gctgacgttc
     5461 cccgcggcga cggccaccac ctcctggccc cggcacgccg tcatccggca gtgcatggcc
     5521 accaggcggc cccgccggcg gcggacggcg gagcagacga tctcggcgtc gatccgggcg
     5581 ggcccctcgc ccacccccag ccggtcgggc cgcagccggt aatcgaggtc ccggatcagg
     5641 aactggtcct ccagcggcac gccgtactcc gtgtgcgcga gcagcatggt cgcctggcgc
     5701 atggtctccc ccaccagctg cggcgggtac tgacggcggc gcggggtgaa gtggtcgtgc
     5761 cggtcgggcc agcggaccga cacccggaac cggtcgtcgt cgacacgctc ccagccggtc
     5821 agcagcacat cgtccgcgcg gagccggtgc accagctccc gggggacggt ttcccacccc
     5881 tcggccccgg tcggcgggcc ctggggagga tcgtccccag gggcggatgc tgaaagatgc
     5941 tcacggaagg ccgaactgtg catggttccc ccctcgtgga acacacaggc agaggctccg
     6001 aggcccccgc cccaggatat taaagatacg tgcatggcgg tatggtcttc aatgacacaa
     6061 ggcaccaagg agcggcaaac cgggggcgtt gttgccggac gaaaggacag cggcatggca
     6121 cagcaggaac gggcgaggaa gaccaaggac gcgatcctcg aagcggcggg agcggtcttc
     6181 gccgaacggg gctacgacgg ggccaccgtg tccgacgtct actcccgggc cgggctgacc
     6241 aaaggggcct tctacttcca cttctcctcg aagaaggacc tggcggagga ggtcctctcc
     6301 atacaggtcg accgccaggg gtacccgatc ctgccgcgcc aggtgaagct ccaggagctg
     6361 gtcgacgcgg ggttcgtctt cgcccaccgg ctcatgcgcg acagcatgct ccagggcagc
     6421 gtcaacctct ccctggagtc cggcgcccac caactggacc gcaaaaggcc gttcgtggcc
     6481 tggatcgacc acaaccagcg ggcgctgacc gaggcgaacg accacggcga gctgtactcg
     6541 cacgtcgata cggcggaggt cgccgagctg atggtctcgt ccttctcggg cgcccagatc
     6601 ctttcgcaca tcctcaccgg ccgccaggat ctgaccaccc gcgtcgccgc gctcctcgcg
     6661 catctgctgc ccacgatcgc cgtacccgcg gtgctggcca ggctggacat cgccgcggac
     6721 cgcggggaac gggtcctggc cgaggccggc gtcggcacca cggccctgcg ccccgcaccc
     6781 ccggggctca cggacacgct ctgaggcacg gccgtccgac acgtggtcag gactgtccac
     6841 ggacagaaag cacgcttggc ctatgcccaa aaaacgtgca tgctggtttt cttggcacca
     6901 gggatctcgg acgggagacg gtcgtcgtga acctgcacca gttacgtacg ttctgcgagg
     6961 tcgcgggcgt gcacagcttc accaaagcag ccaggaacct gcactacgcg cagtccaccg
     7021 tgacatcgca gatccagaac ctggaggact tcctgggggc acccctcttc gagcgcggga
     7081 gccggggcat cgtcctgacc gacgcgggtg tcaggctgct gccctacgcg aacgcgatgc
     7141 tcagtctcgc cgagtcggca caccggcacg tcgcccgctc ccccgtataa gggtcctccg
     7201 gcgtacaagg gtcctccggc cacctccacg acgtcacccc gcgcagccgt ccgcccgccc
     7261 cctccccggg gcgggcggac ggctgtgcgc gttcccaccg gccgcgcgcg cagacgcaat
     7321 tgacggtgcg ttctccagca attgatgcgt gccggaactc ggtagtgtca tcgacatcgc
     7381 accggccctc cctttcggac gggcggcgta tcgccgattt cctggagagg acacatcatg
     7441 ggcgaggtat ccgccaccag ccggccagtc atcaccattc aggacgaact ccgttcggtc
     7501 atgcgcaatt tcgccaccgg agtctgcgtg gtgagcactt tcaccgacgc accgtccgga
     7561 cgtatacaca acgctctcac ggtcaattcc ctcacctctc tctcgctgag cccacccctc
     7621 atttccatca gcattcgact ggaatccaca ttcctcgacg aactgatgga gtcgggagtg
     7681 tgggccgtat ccgtcctgga cggcggcggt gaggacctcg ccaggatctt cgcccgcccc
     7741 gaggaggagc gcaggaggtc gctgcggagc ctgcccaccg agccgggggc cgcgaccggg
     7801 gcggccgttc tggacggtgc ggcctggctg gaatgccgat atcaccagca cgtcgtcacc
     7861 ggcgaccatg tcctggtcat cggtgaggtc gtgggcctgg gcgccgacag cacccgctcc
     7921 cccctggtat tcctgcacgg cggatttcac cgcttcgaac gcgaacaggt ctgacagagc
     7981 ccgattcccc gccaccccgt atcgataggt gactgacata tgtccgcaat ctcgataggt
     8041 gttgtcggag gcggcgcatc cgctgtctgc ctcatcgacg ccctggtcat ggccaaaggc
     8101 ggcccaggca gcctgacggt attcgagcca tcgccgaacc tctggcgggg acgcgcctac
     8161 caggtcgaca gcgaaatcat caaggtcaac gcaacccccg acgacatgtc cgtacgggca
     8221 ggcgatccgc accacttcat ccgctggctg ggcgcccgtg aacgcatgct cggcgagagc
     8281 tacggcctgg accccttctc cggggcgcgg ttcgctccgc gcacggtcta cggcgagtac
     8341 ctggaacaga cggcctacgc cggtctggcc gaactccgac gacagggctg gcgcgtcgac
     8401 ctcgtcggcg actccgtcac ctcggcgcgg cgcaccgagg accaggtcgt ggtgagcacc
     8461 gggcggggca tgacgagctc cttcgactac gtcgtcctct gtgtcggcgg tgacgggccc
     8521 aaggacgtgt acggcctggc gggctccccc ggcttcatcg cggacccgta tcccgtctcg
     8581 cagaatctgc gcacgatcgg cgcggcggag cgggtcgcgg tgatcggcag tggtctcacc
     8641 gccgtcgaca tcgtcctctc cctggcggcc caggggcatc ggggaccgat cagcctggtg
     8701 tcccggcgcg gggtgctccc cggtgtccgg cagcgggagg cccacttcga gctgcgccac
     8761 ctgacacagg aacgcatgcg cgccctggcc cggagcaggc gggagatctc cgtccaggag
     8821 ttcacggcga tcgtccaccg ggaactgcac gacgccgggg tggacctggc ggctctccac
     8881 accgagctgg cctccctcga cggggagtcg ccggccgaca gactgaggcg gcagttcgcc
     8941 gccgtcaacg cctccgacct gggccttcgc attctccagc gggcggtccc ggagatcggg
     9001 cccgacgtct ggccggtgct cggggaacag gaccgggccg aagtactgcg cctgcactac
     9061 cggaccatca tgagtctgtg ctgcccgatg ccgccgagca gtgccgcggt gctgctcggc
     9121 ctgatcgacg aaggccgtct ggacatccgg tccggtctcg actccgcctc cccgggaagc
     9181 ggtgggggcc tcaccctcag cctgctggat ggaacggtcc tgcggacgga ccgcgtgatc
     9241 aacgcggtca gcgcctccga gggccgcata ccgcagggcg ccgcaccgct cgtggacacc
     9301 ttggtcggcg gccgtgccgc aagcctccac ccgcacggcg ggctgcatgt cctgcgcgcc
     9361 accagccagt tgacgacgga cggcacctcg gacccgcggc tctacggact gggcaccatc
     9421 gcggcgggct ccctcttctt caccttcggt gtccagtcgc tggtcgaccg gggggtggac
     9481 atcgtggacg ccatcctgga gcacgccgcc gcgcggacgg cgagccacac cgccgagtcg
     9541 ctgctgccgg cctgagcccg gcccgaccgc gccgcccgcg cgcctggccg cacctcctgc
     9601 ttcccgcacc tccctccctt ttctcccctt ctccgagaac ggagtcgcca tgaccacggt
     9661 ttcgcccctc acccacccgc acgggaccac ttccgcagcg acagctcccg ccggctatct
     9721 cgccgacacg gcgaccggcc tcccgatccc gggagagccc gacttcgcca cccccgagga
     9781 ggcccggcgc caccgcaagc agcgcctggc cgccgctctg cggctgttcg gcaaatacgg
     9841 cttcggcgag ggcatatcgg gccacatctc ggtgcgcgac ccggagtacc cggaccagtt
     9901 ctgggtgaac ccgttcggcg tctcgttcaa gcacgtccgc gtggccgacc tcatctgcgt
     9961 cgactcccgg ggccgcgtcg tccacggcaa gcaccgggtg aatccgagcg ccttcgtgat
    10021 ccactcccag atccacgaac tgcacccggg cgccacggcg gcggcccacg gccacacggc
    10081 gcactcccgc gccctgggcg cgatcggccg tctcctcgac cccatcgatc aggaatcggc
    10141 cgccttctac ggtcgtcaga cgctgtacga ggcgtacgag ggaccgtccg tctccctgga
    10201 gcagggccgc gacatcgccg agaagctggg cgacaaccgt gccatcctcc tgcgccacca
    10261 cgggctgatc acggtgggcg gctcgctgga cgaggcggtg cactggttct tcacctacga
    10321 cagctgcgcc caggtccagt tgctggcccg cgccgccggc accccggaga cgttcaccca
    10381 cgagcaggcg accgccgccg gggaggggtt cggggacgag cagctgggct ggttcagctt
    10441 ccagctgctc tgggacgaga tcgtcgccga gcagcccgac ctgctggagg agtagcggcc
    10501 gaggtgcggc aggcaccacc acccggttcg acagcgactc ccgacagagg aaaggcacat
    10561 gactcaccga ccggaatttc ccacctcccc cgccacctgg cgggggctgc ccgccgcgca
    10621 gcagccaccg tggccggacc agcaggcgct gaaccgggtg ctggcggacc tcgccggctg
    10681 tcctccgctc gtcttcgcgg gcgagtgcga ccggttacgc acccagctcg gtgccgtggc
    10741 ccgcggtgag gcgttcgtcg tgcagggcgg cgactgcgcc gagaccttcg ccggggtgac
    10801 ggccgaccgg atacgcgaca aggtgaagac gctgctccag atggcggccg tcctcacgta
    10861 cgcgacctcc gttccggtgg tcaaggtggg gcgcatcgcg gggcagtact ccaaaccccg
    10921 ctccagcccc accgaacggc gcggagacgt cgagctgccc gtc
//
