LOCUS       NZ_CP029361            11482 bp    DNA     linear   CON 31-MAY-2024
DEFINITION  Streptomyces globisporus strain TFH56 chromosome, complete genome.
ACCESSION   NZ_CP029361
VERSION     NZ_CP029361.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globisporus
  ORGANISM  Streptomyces globisporus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7488586)
  AUTHORS   Cho,G.
  TITLE     Complete genome sequence of Streptomyces globisporus TFH56 isolated
            from tomato flower
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7488586)
  AUTHORS   Cho,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAY-2018) Division of Applied Life Science, Gyeongsang
            National University, Jinjudaero, Jinju 52828, Korea, Republic of
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 29-MAR-2018
            Assembly Method :: canu v. 1.7; arrow polish v. SMRT link 5.1.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 37.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003147545.1-RS_2024_05_31
            Annotation Date                   :: 05/31/2024 02:17:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,917
            CDSs (total)                      :: 6,829
            Genes (coding)                    :: 6,492
            CDSs (with protein)               :: 6,492
            Genes (RNA)                       :: 88
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 337
            CDSs (without protein)            :: 337
            Pseudo Genes (ambiguous residues) :: 0 of 337
            Pseudo Genes (frameshifted)       :: 240 of 337
            Pseudo Genes (incomplete)         :: 121 of 337
            Pseudo Genes (internal stop)      :: 7 of 337
            Pseudo Genes (multiple problems)  :: 31 of 337
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:15:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1229300
            Orig. end                         :: 1240782
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029361.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11482
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11482
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11482
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6482](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6482
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    207..227
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     misc_feature    1299..1313
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.38"
                     /tool="antismash"
     gene            1498..2220
                     /locus_tag="DIJ69_RS05480"
                     /old_locus_tag="DIJ69_05480"
     CDS             1498..2220
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059395.1"
                     /locus_tag="DIJ69_RS05480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_05480"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_241846747.1"
                     /transl_table=11
                     /translation="MAPGPAGRTPVFERRVAGGGRDAGGGSAEKVVALTFDADMTADQG
                     PRAASGERFDNPELVALLRRLKVPSTVFMTGRWAEEYPAQARAIGTDPLFEVANHSYSH
                     HAFSSPCYGLPVVGKNAMTRDVERAFTAFRKAGVRNVVPYFRFPGGCYDDTALRALAPA
                     NVTAVQWDVISGDAFATDAGAVAEQVLDGVRPGSLVVMHCTRSAAPATEAAVRRIVPEL
                     RERGYRFVKVSELMEDGG"
     gene            complement(2239..2457)
                     /locus_tag="DIJ69_RS05485"
                     /old_locus_tag="DIJ69_05485"
     CDS             complement(2239..2457)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059396.1"
                     /locus_tag="DIJ69_RS05485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_05485"
                     /product="hypothetical protein"
                     /protein_id="WP_044375451.1"
                     /transl_table=11
                     /translation="MSRETDDPHGEGTYCDSPEPSTTAPPYGAAGGPPYAECVLCREPT
                     EYPESTKGATLCPVCAWQEAGRTACSG"
     gene            complement(2454..3128)
                     /locus_tag="DIJ69_RS05490"
                     /old_locus_tag="DIJ69_05490"
     CDS             complement(2454..3128)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378552.1"
                     /locus_tag="DIJ69_RS05490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_05490"
                     /product="AIM24 family protein"
                     /protein_id="WP_010059397.1"
                     /transl_table=11
                     /translation="MKSDLFSSEHMAQPATAPGMTLQNAKSIKYAVNGEMHARQGSMIA
                     FRGNLQFERKGQGIGGMLKRAVTGEGLALMAVRGQGEAWFAHEAANCFIVELDQGDSIT
                     INGRNVLCFDPTLSYEIKTVKGAGMVGGGLFNSVFTGYGKLGLMCEGTPIVIPVTAAQP
                     VYVDTDAVVGWSQQLTTSLNRSQSVGSMVRGGSGEAVQLMLQGEGFVIVRPSEARPEKT
                     AN"
     gene            3200..3928
                     /locus_tag="DIJ69_RS05495"
                     /old_locus_tag="DIJ69_05495"
     CDS             3200..3928
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072531.1"
                     /locus_tag="DIJ69_RS05495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_05495"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_044375448.1"
                     /transl_table=11
                     /translation="MTSHDTPSPASGSPFRSGPTDRDQAPQFVLPLVLHLEKTDPPART
                     DALRAAARAVLTILSDERSHGDGAWAAAMRDWQDARIRKVVRRARGAEWRKAAALDGIT
                     VTGEDGAEVRVFPPIPLDGWPKELAKLQVSGTDLDDPEPPAAPDLSGPVLWLNPDVDMS
                     AGKTMAQAGHGAQLAWWELSETERKAWREAGFPLSVATPGPERWRELTASGLPVVRDAG
                     FTEIAPGSCTVIADHPALRR"
     gene            4132..4878
                     /locus_tag="DIJ69_RS05500"
                     /old_locus_tag="DIJ69_05500"
     CDS             4132..4878
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072530.1"
                     /locus_tag="DIJ69_RS05500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_05500"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_172593864.1"
                     /transl_table=11
                     /translation="MRRINGTALIIAALVATLGALAFPVWSYADRSGTGEANLNASSVA
                     TQWGPLSATDRDFLVKVRLAGLWELPAGQQAIERAPSEATKAAGDHLVVGHTDLDRRAR
                     DVAAKLGVELPNQPTAQQQEWLRELTAASGDAYERKFANILRAAHGKVFGLIGQVRHTT
                     RNTLIRQLASDANQTVLDHITMLEATGFVDFDALAREAVSGSTSSPSGPSMPRDGQAPL
                     APVPVTPTGDQSFTSRPVPPTMMPMP"
     gene            5001..6482
                     /locus_tag="DIJ69_RS05505"
                     /old_locus_tag="DIJ69_05505"
     CDS             5001..6482
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072529.1"
                     /locus_tag="DIJ69_RS05505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_05505"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_044375443.1"
                     /sec_met_domain="DUF692 (E-value: 9.2e-90, bitscore: 299.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELGIGIGWRPEIAAEVESLGGIDWVEAVAENLCADHLPDSLVRL
                     RERGVTVVPHGVALGLGGADRPDPDRLAGLAARAGLLGAPLVTEHIAFVRAGGPLTASP
                     RLEAGHLLPVPRTWDALDVLCENVRIAQDSLPVPLALENIAALITWPDEELTEGQFLAE
                     LVERTGVRLLIDVANLHTNHVNLGQDPAKALDELPVEAIAYVHVAGGVEKNGVWHDTHA
                     HPLSEPVLEVLAELRSRVDPPGVLLERDDAFPPGAELAGELDAIRATLRKAAPSAGPGP
                     DRAAPRKAVPSADRRNALEQVAPSTGQGPDRAAARKADPSADRGPVASPAPRPDQAPAS
                     DGSAGAGARTDTSAPVSAGTRDRTAVAQTALLSALVAGTPAPEGFDHRRLRVQSRALAA
                     KRADVVAKVAPELPEILGDGYRAAFLAYAGSRPMSGGYRRDALDFAEHVLIAGGPADPA
                     ARRRLTYWWQDRSGARPPRRTTRLVRAARAALVGK"
     gene            6488..7540
                     /locus_tag="DIJ69_RS05510"
                     /old_locus_tag="DIJ69_05510"
     CDS             6488..7540
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072528.1"
                     /locus_tag="DIJ69_RS05510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_05510"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_030804381.1"
                     /transl_table=11
                     /translation="MNTLALLATLAIVVSSVLLVAKAVAERSRRPSPGPGVALHDLYEV
                     AFLNGGPARVVDTALTALHADGRLAVGGPGIVAVQRAQANDPVERAVFQELAAAPNGAL
                     HVLREAVMRHPAVQEVGDGLAARGLLVPPHRLRPLRRWGLTQGTVCLIALPLSLLLTFV
                     QFATDDSLDFSVPFIVKMLPAIVIGSFTGLIVANTSAGRLTASGRHAAQSFRAAYAYVV
                     TPAHLVATLGLRALPDPVFQAQLMAAARLSAPRRRSSGRVGGSTATGVTAVGVATVWCA
                     ASGPGGSSCGGSTGGGSGSSCGGGSGCSSGSGCGGGSGSSCGGGSSCGSSSGSSCGGGG
                     GGSSCGGGGS"
     gene            7691..9253
                     /locus_tag="DIJ69_RS05515"
                     /old_locus_tag="DIJ69_05515"
     CDS             7691..9253
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (101-476). E-value:
                     7.8e-20. Score: 63.4. Matches aSDomain:
                     nrpspksdomains_DIJ69_RS05515_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956907.1"
                     /locus_tag="DIJ69_RS05515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_05515"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_044375441.1"
                     /sec_met_domain="PF00561 (E-value: 3.4e-25, bitscore: 87.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTAALYTSIGSLVLSALAAAPAGAWERPGSAEARGTAIAAARAT
                     AAGIDFAACPEEEMLPDSLKCGTVKVPLDYAEPDGRQLELTVSRTPATGPAEERQGAFV
                     YNPGGPGASSITFPLAGELPEWKEIAEAYDLVGYAPRGVNGSSAPLSCQDPAAYTKGPT
                     DAPTHPNQEDKERRVARAKAYAQGCAEHAGETLRHYTSLNNARDLDVLRAALGESRLTF
                     MGASYGTYFGALYATLFPSHVRRMVFDSAVDPDPEQIWYRSNMGQSLAFEARWEDFRRW
                     VAKHDDVYHLGTTPEAVQRRYDEVRAELAVKPAGGKVGPGQLHSAFLGAGYYDDYWAMR
                     ATALSEYVRGNPEPLVAQASPRAVAAKDNENAQAVYTAVECNDAPWPEDFEVWDRDHTE
                     LARVAPFETWDNAFSNLPCAFWPAPRQRPLDVRVGWGELPPTLILAAERDAATPYKGAL
                     ELRKRLPGSSLVTERDAGTHGIGGAGNTCVDDHLRRYLLTGEVPGRGADCAAHPEPNPV
                     SLD"
     aSDomain        7994..9118
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DIJ69_RS05515_Abhydrolase_1.1"
                     /evalue="7.80E-20"
                     /label="DIJ69_RS05515_Abhydrolase_1.1"
                     /locus_tag="DIJ69_RS05515"
                     /protein_end="476"
                     /protein_start="101"
                     /score="63.4"
                     /tool="antismash"
                     /translation="AFVYNPGGPGASSITFPLAGELPEWKEIAEAYDLVGYAPRGVNGS
                     SAPLSCQDPAAYTKGPTDAPTHPNQEDKERRVARAKAYAQGCAEHAGETLRHYTSLNNA
                     RDLDVLRAALGESRLTFMGASYGTYFGALYATLFPSHVRRMVFDSAVDPDPEQIWYRSN
                     MGQSLAFEARWEDFRRWVAKHDDVYHLGTTPEAVQRRYDEVRAELAVKPAGGKVGPGQL
                     HSAFLGAGYYDDYWAMRATALSEYVRGNPEPLVAQASPRAVAAKDNENAQAVYTAVECN
                     DAPWPEDFEVWDRDHTELARVAPFETWDNAFSNLPCAFWPAPRQRPLDVRVGWGELPPT
                     LILAAERDAATPYKGALELRKRLPGSSLVTERDAG"
     gene            complement(9407..10135)
                     /gene="hemQ"
                     /locus_tag="DIJ69_RS05520"
                     /old_locus_tag="DIJ69_05520"
     CDS             complement(9407..10135)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965515.1"
                     /locus_tag="DIJ69_RS05520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DIJ69_05520"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_006128414.1"
                     /transl_table=11
                     /translation="MSAPETVTSSKSPNAGKKAKDLNEVIRYTLWSVFKLRDVLPLDRA
                     GYADEVQELFDQLAAKDITVRGTYDLSGLRADADIMIWWHAETSDQLQDAYNLFRRTKL
                     GRALDPVWSNMALHRPAEFNKSHIPAFLADETPRDYISVYPFVRSYDWYLLPDEDRRRM
                     LADHGKMARGYPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRASEARLHVRE
                     EVPFYTGRRKSVADLVAGLA"
     misc_feature    complement(11098..11113)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.74"
                     /tool="antismash"
ORIGIN
        1 cgacggctac ggccccctcg tccccgatcc ggacggtctg ctcgacctgc cgaaaggatt
       61 ccgctaccgg gtgctgtccc gggagggcga gccgctgcgc tccggcgagg gcccggtgcc
      121 gagcaaccac gacggcatgg cggccctgcg gggccgcaac gggcggatcc acctggtccg
      181 caatcacgag aaccggcaca cggccgagat cggcgtgccg acgattgagg ggctgaccta
      241 cgacccggcg gccaagggcg gctgtacgtc gctggagctg gacggccgca acaaggtgct
      301 cggcgagcgg gtcgccatcg cgggtaccgc ggtcaactgc gcgggcgggc ccaccccctg
      361 gcgcacctgg ctgacctgcg aggagaacga ggacaaggcc gggaccaacg ggtacaccaa
      421 ggaccacggc ttcatcttcg aggtggacgg cgccgatccg cgccgcaccg gggccgtccc
      481 gctgaccgcg atgggccgtt tccagcacga agcgatcgcc gtcgacccga agtcggggat
      541 cgtctacgag acggaggacg cgttcgagaa gccgttcggg ctcttctacc gcttcctccc
      601 cgagaagccg ctcggcggca ccggttcgct ccgggcgggc ggtgagctgg aggcgatgcg
      661 ggtcccgggc gtgcccgacc tgtcggtcgt ccaggagacg gggaccagct tcgaccggat
      721 cgagtgggtc cccgtaccgg atccgctggc gaaggagacg gcgatccgct tccaggactt
      781 cgggccgaag gggatcacgc acgcgcagaa actggagggc tgctactggg gcggctcgtc
      841 ggtctacttc gtctccagct tcgcccaccg cgacgagggc tcggcagccg accactacgg
      901 ccaggtgtgg cgctacgagc cgaagaagcg acggctgacc ctggtggtga tcttcggccc
      961 ggacaccgac atccagctgc ccggcgagtc ccccgacaac atctgcctgg cggccgacgg
     1021 cgggctgatg gtctgcgagg acggtggcgg cgcgcagcat gtgctcgggg tgacccggcg
     1081 cggcgaggtg tacgcgatgg cacgcgggcg gcagaacatc gggacgcccg aggagccgga
     1141 gtggggcgag ttcgcggggg tcacgttctc accggacggc tcgacgatgt acgtgaactg
     1201 ctacacgccg ggaacgacgt tcgcggtgac ggggccgtgg tgctgaggta gccacttccc
     1261 ggcgcccgcc ttcggagtgc caccgaccga tattgccata ttgtcggata ttttccgtga
     1321 gtgatcactg ctgcacggaa gacccggaag gcacggaagg cacggcaggc gacggttctg
     1381 gcggtcgcgg tggtgctgac cggcaccgcc ctgaccgggt gcgggggcga ggcccccgca
     1441 cccgctcccc cacacccgcc cgcttcggcc tcccccgccc cgaagaagcc gccgacgatg
     1501 gcccccggcc cggcgggccg caccccggtc ttcgagcgga gagtggcggg cgggggcagg
     1561 gacgcgggcg gcgggtcggc ggagaaggtc gtggcgctca cgttcgacgc cgacatgacg
     1621 gccgatcagg gcccccgggc cgcctcgggt gagcggttcg acaatccgga gctggtcgcg
     1681 ctgctgcgcc ggctgaaggt gccctccacg gtcttcatga ccggccgctg ggccgaggag
     1741 tacccggccc aggcgagggc catcggtacc gaccccctct tcgaggtcgc caaccactcc
     1801 tacagccacc acgcgttcag ctccccctgc tacgggctgc cggtggtcgg caagaacgcg
     1861 atgacccgcg acgtcgaacg cgccttcacc gcgttccgga aggcgggtgt gcggaacgtg
     1921 gtgccgtact tccgcttccc cggcggctgt tacgacgaca cggccctgcg cgccctggcc
     1981 ccggcgaacg tgacggccgt ccagtgggac gtgatcagcg gcgacgcctt cgccacggac
     2041 gcgggcgcgg tggccgagca ggtgctggac ggggtccggc cgggctcgct cgtggtgatg
     2101 cactgcaccc gcagcgcggc cccggccacc gaggcggcgg tacgccggat cgtgccggag
     2161 ctgcgcgagc gcgggtaccg cttcgtgaag gtgtcggagc tgatggagga cggcggctga
     2221 gccggggcgg gtcgtcagtc agccggagca ggccgtgcgc cccgcctcct gccaggcgca
     2281 gaccgggcag agcgtggccc ccttcgtcga ctccgggtac tcggtcggct cgcggcacag
     2341 cacgcactcg gcgtacggag ggcctccagc ggctccgtac ggcggggcgg tcgtgctcgg
     2401 ctccggggag tcgcagtacg tgccctcgcc gtgcgggtcg tccgtttccc ggctcaattg
     2461 gcggtcttct cgggcctggc ctcgctcggg cggacgatga cgaagccctc gccctggagc
     2521 atcagctgga cggcctcgcc ggagccgccg cggaccatcg agccgacgct ctgggagcgg
     2581 ttcaggctgg tcgtgagctg ctggctccag ccgacgaccg cgtccgtgtc cacgtacacc
     2641 ggctgggcgg ccgtcacggg gatcacgatc ggggtgccct cgcacatcag gccgagcttg
     2701 ccgtatcccg tgaaaacgct gttgaagagg ccgccgccga ccattccggc gcccttcacc
     2761 gtcttgatct cgtaggagag ggtggggtcg aagcagagga cgttgcggcc gttgatggtg
     2821 atcgagtcgc cctggtccag ctccacgatg aaacagttcg ccgcctcgtg cgcgaaccat
     2881 gcctcgccct ggccgcggac ggccatcagc gcgaggccct cgccggtgac ggcgcgcttg
     2941 agcatgccgc cgataccctg gcccttgcgc tcgaactgga ggttgccgcg gaaggcgatc
     3001 atcgagccct gccgggcgtg catctccccg ttgacggcgt acttgatgga tttcgcgttc
     3061 tgcagggtca tccccggggc ggtggccggc tgggccatgt gctcgctgga aaagagatcg
     3121 ctcttcatgc ggagcatcct cacccggacc cggtcgttcc gccaagcagg tgacctcgtc
     3181 cgcctggcag actgggacgg tgaccagcca tgacaccccc tcccccgcct ccgggagccc
     3241 gttccgcagc ggcccgaccg accgcgatca ggcgccgcag ttcgtgctgc ctctggtgct
     3301 gcacctggag aagacggacc cgcccgcccg caccgacgcg ctgcgggccg ccgcccgggc
     3361 ggtgctgacg atcctctccg acgagcgttc ccacggcgac ggcgcgtggg cggcggcgat
     3421 gcgggactgg caggacgccc ggatccgcaa ggtcgtgcgc cgggcgcgcg gtgcggagtg
     3481 gcgcaaggcg gcggcgctcg acggcatcac ggtgacgggc gaggacggcg cggaggtacg
     3541 ggtgttcccg ccgatcccgc tggacggctg gcccaaggag ctggccaagc tccaggtgtc
     3601 gggcaccgac ctggacgacc ccgagccgcc cgccgccccc gatctgtcgg gcccggtgct
     3661 gtggctgaac cccgatgtcg acatgtcggc gggcaagacg atggcccagg ccgggcacgg
     3721 cgcgcagctc gcctggtggg agctgtccga gaccgagcgc aaggcctggc gcgaggccgg
     3781 gttcccgctc tccgtggcca cccccgggcc ggagcgctgg cgggagctga cggcgagcgg
     3841 gctgccggtg gtgcgcgacg cggggttcac cgagatcgcc cccggctcct gcacggtgat
     3901 cgccgaccac ccggcgttgc gccgctgatc gggacggcga ccacagcggg tcccccgtcg
     3961 cggagccgcg accacatcgc ccgcgcgctg aacgtttctc gttcctctta cgtacctccc
     4021 ggtactgccc tgtcggcagt accgccaagt agcctgcgca gccagtcgat tggcggttga
     4081 tcgacgcctg ttcgatcgac gctgtcacgc ctcggcccgg gagacacctt gttgcgacgc
     4141 atcaacggca cggccctcat catcgcggca ctggtcgcca cactcggcgc gctcgcgttc
     4201 cccgtctggt cctacgcgga ccgttcgggc accggcgagg cgaatctcaa cgcctccagc
     4261 gtcgccaccc agtgggggcc gctctccgcg accgaccggg acttcctggt caaggtgcgg
     4321 ctcgccgggc tgtgggagct gcccgccggg cagcaggcga tcgagcgggc gcccagcgag
     4381 gcgacgaagg ccgccgggga ccacctcgtc gtcgggcaca cggacctgga ccggcgggcc
     4441 cgggacgtcg cggcgaagct cggggtggag ctgcccaacc agcccaccgc ccagcagcag
     4501 gagtggctgc gggagctgac ggcggcgagc ggtgacgcgt acgagcggaa gttcgccaac
     4561 atcctgcgcg ccgcccacgg caaggtcttc ggcctgatcg gccaggtccg ccacaccacc
     4621 cggaacacgc tgatccggca gctggcgagc gatgccaacc agaccgtgct ggaccacatc
     4681 accatgctgg aggcgaccgg gttcgtcgac ttcgacgccc tggcgcgcga agcggtgagc
     4741 gggtcgacgt ccagtccttc cggcccgtcg atgccccggg acggccaggc cccgctggcc
     4801 ccggtgccgg tgacgccgac cggcgaccag tccttcacct cgcgcccggt gccgcccacg
     4861 atgatgccga tgccataacg acggcggcgg gtccggaacc tcaaatgaag ctctgaacgt
     4921 ccccccggtc gggttcatcg ccgcgcgacg gggccatgac ccctgggcag aacgaggtga
     4981 gcagggggac gggggacgtc atggaactgg gtatcggtat cggctggcgg ccggagatcg
     5041 cggccgaggt ggaatcgctg ggcgggatcg actgggtgga ggcggtcgcg gagaacctct
     5101 gcgccgacca tctcccggac tcgctggtgc ggctgcggga gcgcggggtg accgtcgtgc
     5161 cgcacggggt ggcgctcggg ctcggcggcg cggaccgccc cgaccccgac cggctcgccg
     5221 gtctcgcggc gcgcgccgga ctgctggggg cgcccctggt gaccgagcac atcgcgttcg
     5281 tacgggccgg ggggccgctg accgcgtcgc cgaggctgga ggcggggcac ctgctgccgg
     5341 tgccccgcac ctgggacgcg ctggacgtgc tgtgcgagaa cgtgcggatc gcgcaggact
     5401 cgctgccggt gccgctcgcc ctggagaaca tcgccgcgct gatcacctgg ccggacgagg
     5461 agctcaccga ggggcagttc ctggcggagc tggtcgagcg gaccggggtg cggctgctga
     5521 tcgacgtggc caatctgcac accaaccacg tcaacctcgg ccaggacccg gcgaaggcgc
     5581 tggacgagct gccggtggag gccatcgcgt acgtccatgt ggcgggcggg gtcgagaaga
     5641 acggcgtctg gcacgacaca cacgcccacc ctctgtccga acccgtcctg gaggtgctgg
     5701 ccgagctgcg ctcccgggtc gatccgcccg gcgtgctgct ggagcgggac gacgccttcc
     5761 cgccgggcgc ggagctggcg ggcgaactcg acgcgatccg ggcgacgctg cggaaggcgg
     5821 caccctcggc gggtccgggg ccggaccggg cggcgcctcg gaaggccgtc ccctcggcgg
     5881 accggaggaa cgctctggag caggtggcac cctcgacggg ccaggggccg gaccgggcgg
     5941 cggcgcggaa ggccgaccct tcggcggacc gggggccggt cgcgagcccg gccccgaggc
     6001 cggaccaggc tcccgcgtcc gacggcagcg ccggcgccgg ggcccgtacg gacacatccg
     6061 cccccgtgtc cgccggcacc cgcgaccgta ccgccgtcgc gcagaccgcc ctgctctccg
     6121 ccctggtcgc cggaacgccc gcccccgaag gcttcgacca ccggcggctg cgggtgcaga
     6181 gccgggcgct ggcggccaag cgcgccgacg tcgtcgccaa ggtggccccc gaactgccgg
     6241 agatcctcgg cgacggctac cgtgccgcgt tcctcgcgta cgccgggagc cgcccgatgt
     6301 ccggtggcta ccgccgggac gccctggact tcgcggagca cgtgctcatc gcgggcggtc
     6361 cggccgatcc ggcggcgcgg cgccggctga cgtactggtg gcaggaccgg tcgggcgccc
     6421 ggcccccgcg ccgtacgacc cgtctcgtcc gggcggcccg tgccgccctc gtggggaagt
     6481 gaccgccatg aacacgctcg ctctgctggc gaccctcgcg atcgtcgtct cgtcggtgct
     6541 gctcgtcgcc aaggcggtgg ccgagcggtc ccgccgtccc tctccgggcc ccggcgtcgc
     6601 cctgcacgac ctgtacgagg tcgccttcct gaacggcggt ccggccaggg tcgtggacac
     6661 cgccctgacc gccctgcacg cggacggccg gctggccgtc ggcggacccg gcatcgtcgc
     6721 cgtacagcgg gcacaggcga acgacccggt ggaacgtgcg gtgttccagg agctggccgc
     6781 cgccccgaac ggcgccctgc acgtcctgcg ggaagcggtc atgcggcacc cggcggtcca
     6841 ggaggtgggc gacgggctcg cggcgcgcgg gctgctggtg ccgccccacc ggctccgccc
     6901 gctgcggcgg tgggggctga cccaggggac cgtgtgcctg atcgccctcc cgctgagcct
     6961 gctgctgacg ttcgtccagt tcgccacgga cgactccctg gacttctcgg tcccgttcat
     7021 cgtgaagatg ctgcccgcga tcgtgatcgg ctctttcacc gggctgatcg tcgccaacac
     7081 ctcggcgggc cgcctcacgg cgtcggggcg ccacgccgcc cagtcgttcc gggccgccta
     7141 cgcctacgtg gtgacccccg cccatctcgt cgccaccctg ggccttcgcg ccctgccgga
     7201 tccggtgttc caggcccagt tgatggccgc ggcacggctg agcgctccgc gacggcggtc
     7261 ctccgggcgc gtcggcggat ccacggcgac gggtgtcacc gccgtcggcg tggcgacggt
     7321 ctggtgcgcc gcgtccggtc ccggcggctc cagttgcggg gggtcgaccg ggggcggctc
     7381 cggatcgagc tgcggaggcg gctccgggtg ctcctcgggg tccgggtgcg gaggcggcag
     7441 cgggtcgagc tgcggcggtg gctccagttg cggcagctcc agcggctcca gctgtggggg
     7501 cggaggcggc ggatccagct gtgggggcgg cggctcctga agcggcaccc ctgggcctga
     7561 atcagttgcg tacgtcagga ctttgatcgg ccgtcagggt ggattccggt gacattccgg
     7621 ggcggtgctg gacatatccg cccggccgcc cgaccatccc tctccgcatc cgcagagagg
     7681 ccccccgcgc gtgagaactg ctgcgctcta cacatcgatc ggctccctgg tcctgtccgc
     7741 cctcgccgcc gctccggcgg gggcctggga acgccccggc tccgccgagg cccggggcac
     7801 cgcgatcgcc gccgcccggg ccaccgccgc cgggatcgac ttcgccgcct gccccgagga
     7861 ggagatgctc ccggactccc tgaagtgcgg cacggtgaag gtgcccctcg actacgcgga
     7921 gccggacggg cggcagctcg aactgaccgt cagccggacg cccgccaccg gtccggccga
     7981 ggagcggcag ggcgccttcg tctacaaccc gggtggcccc ggcgcgtcca gcatcacctt
     8041 cccgctggcc ggggagctgc cggagtggaa ggagatcgcc gaggcgtacg acctggtcgg
     8101 ctacgccccg cgcggggtga acggctcctc cgccccgctg agttgccagg acccggccgc
     8161 gtacacgaag ggcccgaccg acgccccgac gcatccgaac caggaggaca aggagcggcg
     8221 cgtcgcccgg gcgaaggcgt acgcgcaggg gtgcgcggaa cacgcgggcg agacgctgcg
     8281 gcactacacc tcgctgaaca acgcccggga cctggacgtg ctgcgagccg cgctcggcga
     8341 gagccggctg acattcatgg gggcgtcgta cgggacgtac ttcggggcgc tgtacgcgac
     8401 gctgttcccc tcccacgtac gccgcatggt cttcgattcg gcggtggacc cggacccgga
     8461 gcagatctgg taccgctcca acatgggcca gtcgctggcc ttcgaggcgc gctgggagga
     8521 cttccgccgc tgggtcgcca agcacgacga cgtgtaccac ctggggacca cccccgaggc
     8581 ggtgcaacgg cgctacgacg aggtgcgcgc cgagctggcg gtgaagccgg ccggcggcaa
     8641 ggtcgggccc gggcagctgc actcggcatt cctgggggcc ggttactacg acgactactg
     8701 ggcgatgcgg gcgacggcgc tgtcggagta cgtccggggc aatccggagc cgctggtcgc
     8761 gcaggcgtcg ccgcgcgcgg tggcggcgaa ggacaacgag aacgcccagg cggtgtacac
     8821 ggccgtcgag tgcaacgacg cgccctggcc cgaggacttc gaggtctggg accgtgacca
     8881 cacggaactg gcgcgcgtcg cgcccttcga gacgtgggac aacgccttct cgaacctgcc
     8941 gtgcgccttc tggccggctc cccggcagcg gccgctggac gtccgcgtgg gctggggcga
     9001 gctgccgccc acgctgatcc tggcggcgga gcgggacgcg gcgaccccgt acaagggggc
     9061 actggagctg cggaagcggc tgcccggctc gtcgctggtg acggagcggg acgcggggac
     9121 gcatggcatc ggcggggccg ggaacacctg cgtcgacgat catctgcgcc ggtatctgct
     9181 gaccggcgag gtgccggggc ggggtgcgga ctgtgccgcg cacccggagc ccaaccccgt
     9241 gtcgctggac tgacgtcggg agagaacgga gcgggggccg ccgcaccttc acggtgcgac
     9301 ggcccccgaa gccgaacccg gtgtcgctgg agaggcggac ggcacgatcg gtgcccggtg
     9361 cccgactctc tgatcttccg ggttggggtg acgcgggact cgctggttat gcgagcccgg
     9421 ccaccaggtc tgcgacgctc ttcctgcggc ccgtgtagaa cgggacctcc tcgcgcacgt
     9481 ggagccgtgc ctcggaggcg cgcaggtgac gcatcaggtc gacgatgcgg tacagctcgt
     9541 ccgcctcgaa ggcgaggatc cactcgtagt cgccgagcga gaacgaggcg acggtgttgg
     9601 cgcggacgtc ggggtagccc cgggccatct tgccgtggtc cgcgagcatg cggcggcggt
     9661 cctcgtcggg cagcaggtac cagtcgtagg accggacgaa ggggtagacg ctgatgtagt
     9721 cgcgcggcgt ctcgtcggcg aggaacgccg ggatgtgcga cttgttgaac tcggccgggc
     9781 ggtgcagcgc catgttcgac cagaccgggt cgagcgcgcg gccgagcttg gtgcgcctga
     9841 agaggttgta cgcgtcctgg agctggtccg aggtctcggc gtgccaccag atcatgatgt
     9901 ccgcgtcggc ccgcagcccg gacaggtcgt aggtgccccg gacggtgatg tccttggccg
     9961 cgagctggtc gaacagctcc tgcacctcgt cggcgtagcc cgcgcggtcc agcgggagca
    10021 cgtcgcgcag tttgaagacc gaccacaggg tgtagcggat gacctcgttg aggtccttgg
    10081 ccttcttgcc ggcgttcgga ctcttgcttg atgtcacagt ctcaggagca ctcatacggc
    10141 tattgtcccg cctcgctccc cgtgccccga acccgggtcg gcgtggcgat gatctccctc
    10201 gcgatctcgt cggccgcgcg gtgcgcgctc gcgatgcagg cggggatgcc caccccgtcg
    10261 tagaccgcgc cgcagatccg cagggcgggc agcttggcga cctcgtcgcg gatgcgggcg
    10321 acccgggtca gatggccgac cgggtactgc ggcaggccgc cgatccagcg ggtgacctcg
    10381 gtgtcggcgg gccgggcggt gaggccggtg gcggcggcga ggtcgcgcag ggagacggag
    10441 acgagctcct cgtcctcgcg gtggaggtgg tcctcctcgc cgtagcggcc gacggaggtg
    10501 cggagcacga acaggtcggg ggcggcatcg gcgacccact gccacttgtt gctggagaac
    10561 gtggacgcct tgatcgtgtg cccgtcgacc ggcggcacca ggaagccgga gcggccgcgc
    10621 agggcctcgt acgcctcgat gtcggtacgc cggaaggcca gggtgaccag ggccatcgac
    10681 gcgtactcga caccggacag ctcggcggag gcggccgggg actcggcggc gagcagggtg
    10741 cccgccgacc aggcgggggt ggccaggacg atgccgtcgg cggcgatggt ccgggtgtcg
    10801 gtgcggacgg cccagcccgc ttccgtacgg gtcaggccga ggacaggggt ctcggtgagg
    10861 atctcgccgc ccccggcccg tacggcgtcg ccgacggcgg ccgggagggt gccgatgccg
    10921 cccgcgatgc cctggaagac ggggccggtc tgctgccggg cggcggcccg ctcctggatg
    10981 cggcggacac cgtccagcag cgggccgccc tccttcacgg cctcgaagag ctggggtacg
    11041 gcggcgcgca tcgagatccg gtaggcgtct ccggcataga ccccgccgag gaggggctcc
    11101 accagccggt ccacgacctc gcggccgagc cggtcggcga cgtacgcgcc gaccgcgacg
    11161 tcgtcgccga cgggggtcgg ggtgaggtcg cgctcctcgg cgatccgggc caggccttcg
    11221 ggggacagca cctcgccgag gaccgccggg tcgccgggca cgcccatgac gtgccccttg
    11281 ggcatggggc gcagcgcgtc gcgcgtccaa agcgacgcgg tggcggtggc gggcggctgg
    11341 agccggtcgc cgaggcccac ggcctcggcc agcgcgaccg cctcggggcg ccgggcgagc
    11401 atcgactcgg cccccaggtc gacctggacg cccgcgatct cgccggtcat gagcttgccg
    11461 ccgagccggt ccgtggcctc ca
//
