LOCUS       NZ_CP029254            23315 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Streptomyces spongiicola strain HNM0071 chromosome, complete genome.
ACCESSION   NZ_CP029254
VERSION     NZ_CP029254.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces spongiicola
  ORGANISM  Streptomyces spongiicola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7180417)
  AUTHORS   Zhou,S. and Huang,X.
  TITLE     Complete genome sequence of the Type Strain of Streptomyces
            spongiicola HNM0071, the producer of staurosporine
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7180417)
  AUTHORS   Zhou,S. and Huang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-MAY-2018) Institute of Tropical Agriculture and
            Forestry, Hainan University, No 58, Haikou, Hainan 570228, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: ABySS v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 850.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003122365.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 01:04:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,008
            CDSs (total)                      :: 5,921
            Genes (coding)                    :: 5,739
            CDSs (with protein)               :: 5,739
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 182
            CDSs (without protein)            :: 182
            Pseudo Genes (ambiguous residues) :: 0 of 182
            Pseudo Genes (frameshifted)       :: 47 of 182
            Pseudo Genes (incomplete)         :: 161 of 182
            Pseudo Genes (internal stop)      :: 9 of 182
            Pseudo Genes (multiple problems)  :: 32 of 182
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:10:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7058514
            Orig. end                         :: 7081829
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029254.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23315
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="29"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..23315
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23315
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:13315](-)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13315)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     misc_feature    complement(472..486)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            complement(543..2183)
                     /locus_tag="DDQ41_RS30655"
                     /old_locus_tag="DDQ41_30655"
     CDS             complement(543..2183)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000070: Oxidation (63% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_113703826.1"
                     /locus_tag="DDQ41_RS30655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30655"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_109297385.1"
                     /transl_table=11
                     /translation="MTYSGERTDVLVVGGGPVGMAVALDLTYRGIDCMVVDAGDGQVRH
                     PKVSTIGPRSMELFRRWGVADAVRGAGWPADHPLDIAWVTRVGGHEVYRYRRGTAASRP
                     AFVHTPEPDQICPAHWLSPVLSRALGVHPAGPLRLLTTVDRVLPADDHVEAVLTDRATG
                     RTGTVRARFLVACDGASSPIRRACGIEAPGRHRTQVFRNVLFRAPELRERLGDRAALVY
                     FLMLSSTLRFPMRSLNGGDLYNLVVGADGDRGARADALSLIHDALAFDTPVEVLGDSEW
                     HLTHRVADRYRAGRVLLAGDAAHTLSPSGGFGLNTGIADAADLGWKLAATLNGWAGRHL
                     LDTYDTERRPIALESLNEANTNLQRTMSRELPPGIHLDGPEGERARTEMAGRLASSGAR
                     REFDAPQIHFGLRYRSPAIVDDPGVPIRQGRPDADWRPGSEPGHRAAHAWWEASTSTLD
                     LFGQGFVLLRFADHDGLPAFERAFAERGVPLTVHRGGDPEIAKLYERSFVLVRPDGHVA
                     WRGDDLPGDPVALVDTVRGDRGEAASGEG"
     gene            complement(2289..3131)
                     /locus_tag="DDQ41_RS30660"
                     /old_locus_tag="DDQ41_30660"
     CDS             complement(2289..3131)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (34-224). E-value: 1.6e-40. Score:
                     130.6. Matches aSDomain:
                     nrpspksdomains_DDQ41_RS30660_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_125458607.1"
                     /locus_tag="DDQ41_RS30660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30660"
                     /product="cyclopropane-fatty-acyl-phospholipid synthase
                     family protein"
                     /protein_id="WP_109297386.1"
                     /transl_table=11
                     /translation="MTDPVQTLPEPEAVGKLYDRLTLSAMSDGTFNPNVHIGYWDTPDS
                     EATVEEAMDRLTDVFIERMRVDGSSHVLDLGCGVGGPGLRVVTRTGARVTGISISEEQI
                     RTAGRLAAEAGLADRAIFRHGDAMRLPFEDASFDAVMALESVCHMPDRQRVFTEVCRVL
                     RPGGRIVLTDVFERHPRKAVRHPGIDKFCRDLMSTTADIDDYVALLHRSGLRLREILDV
                     TEQTTLRLADELGKLAAAEERPAAMDEGNFDFGDDSFKPSDLAGADDFGCLLVTAERP"
     aSDomain        complement(2460..3029)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DDQ41_RS30660_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.60E-40"
                     /label="DDQ41_RS30660_oMT.1"
                     /locus_tag="DDQ41_RS30660"
                     /protein_end="224"
                     /protein_start="34"
                     /score="130.6"
                     /tool="antismash"
                     /translation="VHIGYWDTPDSEATVEEAMDRLTDVFIERMRVDGSSHVLDLGCGV
                     GGPGLRVVTRTGARVTGISISEEQIRTAGRLAAEAGLADRAIFRHGDAMRLPFEDASFD
                     AVMALESVCHMPDRQRVFTEVCRVLRPGGRIVLTDVFERHPRKAVRHPGIDKFCRDLMS
                     TTADIDDYVALLHRSGLRLREILDVTE"
     gene            complement(3383..4009)
                     /locus_tag="DDQ41_RS30665"
                     /old_locus_tag="DDQ41_30665"
     CDS             complement(3383..4009)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890947.1"
                     /locus_tag="DDQ41_RS30665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30665"
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase family
                     protein"
                     /protein_id="WP_147317676.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 1e-56, bitscore:
                     189.7, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKARALTVEGAIEFTPRVFPDDRGRFVSPYQERAFTEAHGAPLFP
                     VAQTNHSVSRRGVVRGIHYTVTPPGTAKYVHCSRGSALDIVVDIRVGSPTFGRWDAVLM
                     DQNDHRASFIPVGVGHAFVALEDDTVMSYMLSECYAAENELSLSVLDPALALPITTDTE
                     PVLSERDRAAITLAEAQRQGLLPDYARCRQIERGLAPERPARPVR"
     gene            complement(4089..5198)
                     /locus_tag="DDQ41_RS30670"
                     /old_locus_tag="DDQ41_30670"
     CDS             complement(4089..5198)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963467.1"
                     /locus_tag="DDQ41_RS30670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30670"
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="WP_109297388.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.7e-115,
                     bitscore: 384.6, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTRVWDYLAEYEAERPDILDAVETVFSSGRLVLGASVRGFEEEF
                     AAYHSVDHCVGVDNGTNAIKLGLQALGIGPGDEVITVSNTAAPTVVAIDSTGATPVFVD
                     VREDDYLMDTGQVGAAVTGRTRCILPVHLYGQCVDMGPLKELAARHGLAVLEDCAQAHG
                     ARQGGTVAGSTGDAAAFSFYPTKVLGAYGDGGATITSDPSVAKRLRRLRYYGMDERYYT
                     LETPAHNSRLDELHAEILRRKLGRLDTYIAGRRAVARRYADGLAGTGLVLPRTVPGNEH
                     VYYVYVVRHPRRDDIIERLKAYDIHLNISYPWPVHTMTGFAHLGYAKGSLPVTEALAGE
                     IFSLPMYPSLAPDLQDKVIHALREVLGTL"
     gene            complement(5266..6252)
                     /locus_tag="DDQ41_RS30675"
                     /old_locus_tag="DDQ41_30675"
     CDS             complement(5266..6252)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377944.1"
                     /locus_tag="DDQ41_RS30675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30675"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_245990832.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.5e-09, bitscore:
                     35.1, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRTPLVTVLGASGFVGSSVTRALANRRIRLRAVARRPSTPAPGQ
                     AETTVVTADLTDREALAEAVAGSDAVIHLLLGDGGWRAAESDPGAERVNVGVMRDLVDV
                     LRPAPGEVTPPLVVYGGAASQVGVPRREPLDGTEPDRPETAYDRQKLAAEQHLLKATAE
                     GRVRGVSLRLPTVFGESAAPGAGDRGVVSAMARRALDGRTLTMWHDGTVRRDLVHVDDV
                     AAAFTAALDHPGSLVGGHWLIGAGRGDALGEVFRLVARTAADVLGRPPVDVVSVEPPAH
                     APATDFRSVTLDSSAFRAATGWHPRIPLHEGVRRAVTALARGRDDPR"
     gene            complement(6272..7717)
                     /locus_tag="DDQ41_RS30680"
                     /old_locus_tag="DDQ41_30680"
     CDS             complement(6272..7717)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963469.1"
                     /locus_tag="DDQ41_RS30680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30680"
                     /product="NDP-hexose 2,3-dehydratase family protein"
                     /protein_id="WP_109297390.1"
                     /transl_table=11
                     /translation="MSSRIVPPPAVPAVRPREDGRLADRIALSAATGRGARARTGDVRA
                     WLAERRRAHVFHVERIPFAELGQWRFEPGSGNLVHRSGRFFTVEGMHVVESGGPFGDGP
                     YREWQQPVVRQPEVGILGILAKEFDGVLHFLMQAKMEPGNANLLQLSPTVQATRSNYTR
                     AHRGAEVQLVDHFLRPDPDRVVVDVLQSEQGSWFYRKTNRNMIVETAGDVPELDDFRWL
                     TLGQIAELLHEDDMVNMNARTVLSCVPYGDTSPGALLSDAQLLSWFTGERSRRDVRAER
                     IPLADVRGWKRGAEAIEHEDGRYFRVVAVSVRAGSREVVHWDQPLVEPVGLGVAAFLVR
                     EIGGVPHVLVHARAEGGFLDTVELAPTVQCTPGNYAHLPPADRPPFLDTVLNAPPSQVR
                     YQAVLSEEGGRFLNARSRYLVVEAGDAPLEPPPAYIWAAPAQLRALTRHGHYLNVEART
                     LLACLNAAAARSRGGLLHGGGHR"
     gene            complement(7735..8562)
                     /locus_tag="DDQ41_RS30685"
                     /old_locus_tag="DDQ41_30685"
     CDS             complement(7735..8562)
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (31-222). E-value: 1.3e-41. Score:
                     134.1. Matches aSDomain:
                     nrpspksdomains_DDQ41_RS30685_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958515.1"
                     /locus_tag="DDQ41_RS30685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30685"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_109297391.1"
                     /transl_table=11
                     /translation="MTQKSDTTADSVGEVYDQFADAGATTAMGGNIHVGYWDDDPGVPL
                     AEATDRLTDLVADRLDLRPGRRLLDVGCGIGVPALRVAEAHDVHVTGITVSGQQVAEAA
                     ERAVGAGLGCRVSFRLADATDLPFHDGSFDGAFAIESLLHMADQTRALKELHRVVRPGG
                     RLAVADLCLRQPFSGGDRAVLDGMLRMYEIAGINTPEEHRAHLAAAGWELLELTDIGEQ
                     VRASYGHAAAAFRELAESLDSGAAEQMAAAADLMEGVGSHPHTGYVLITAQRS"
     aSDomain        complement(7897..8469)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DDQ41_RS30685_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.30E-41"
                     /label="DDQ41_RS30685_oMT.1"
                     /locus_tag="DDQ41_RS30685"
                     /protein_end="222"
                     /protein_start="31"
                     /score="134.1"
                     /tool="antismash"
                     /translation="IHVGYWDDDPGVPLAEATDRLTDLVADRLDLRPGRRLLDVGCGIG
                     VPALRVAEAHDVHVTGITVSGQQVAEAAERAVGAGLGCRVSFRLADATDLPFHDGSFDG
                     AFAIESLLHMADQTRALKELHRVVRPGGRLAVADLCLRQPFSGGDRAVLDGMLRMYEIA
                     GINTPEEHRAHLAAAGWELLELTDIGEQ"
     gene            complement(8606..9865)
                     /locus_tag="DDQ41_RS30690"
                     /old_locus_tag="DDQ41_30690"
     CDS             complement(8606..9865)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890954.1"
                     /locus_tag="DDQ41_RS30690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30690"
                     /product="cytochrome P450"
                     /protein_id="WP_109297392.1"
                     /sec_met_domain="p450 (E-value: 7e-24, bitscore: 82.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRATLPRFDLTGWAREDISHPYPVYRRYREAAPVHRTASGAGGP
                     DTFYLFAYDDVVRVLSDRRFGRSARAASGDTGTRAAPVPVPAEHRALRTIVENWLVFLD
                     PPRHTELRSLLNTRFSPSIVTDLRPRITRLARELVERLGGHREADLVEGFAAPFPVLVI
                     SELLGLPEEDRAWLRAGAVALQEASTTRSRGAGGYARAETASREFARYFRQQVDRRSGG
                     DGADLLTLLVRARDSGARLTVDGIVGTCVHLLTAGHETTTNFLAKAVLALRAHPEILAE
                     LRAAPRLTPSAVEELMRYDPPVQAVTRWAYEDAHLGGHDVPRGSRVVALLGSANRDPAR
                     FPDPDVLDVHRAADRHLGFGLGIHYCLGATLARAEAEIGLGTLLDRIPGLGLGGHRVEY
                     ADDLVFHGPTRLVLDLSDLP"
     gene            complement(10001..13315)
                     /locus_tag="DDQ41_RS30695"
                     /old_locus_tag="DDQ41_30695"
     CDS             complement(10001..13315)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indsynth"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031967.1"
                     /locus_tag="DDQ41_RS30695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30695"
                     /product="ferritin-like domain-containing protein"
                     /protein_id="WP_109298028.1"
                     /sec_met_domain="indsynth (E-value: 0.0, bitscore: 1629.0,
                     seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFDLPRLHFAGTATTHAPTGARSGLVDLATNTALTADGQPFPP
                     HRPPGEYHDHLDLIGPRYDSTGRPADDGPFSAAKGEDFAGNGHFAVDARITAVECRAGE
                     PDTGDPVIGRAVDMWGHYNEYLGTTVNRARVFDVDPASDWTTTLMVGQFCFGRDGRSHD
                     VGYMATGDVHGFHPPRWHNTHHVRDVGEHWLAKRLRRSVVHQFVVAGDGEPAWLDEAAV
                     SPAVRRLRDTVACGEAGGLVVQFALGHASAPEAPDRPGRWRLRGTIAPWRPCEPRTYPA
                     GRLLVPSRPGPGGPHNLTVHLTDDHAMLNMITAMPVSGPVRDGRAEARPVDMGDLELRT
                     ADSGRLVARVPRQTYLGEAYALAGGLVTVPVEMPAREAAEEALHLVGTGPGGPVVHLRE
                     KEVNVQADDAALILEHPRDADDPDHDAEVLVRSFVRGRPAAVGGIGVRQFFNPRALPRD
                     PVAASPDARCSDVGVVRVRAGRRDGGDGGGDGGGGGGGWSSTCVLDTDDEGRGWFTLRG
                     AASGTARVLLSTGPDDLPCDPDRPGSAALGYDHGDTLGYWPGAGYLAVRVLPDDWRLAG
                     TDRDQDEDEDEVSFDLVYEEVFAFYEHTYSFMKAEVFSLADRCKVETYAKLIWQMCDPR
                     NKSKTYYMPPTRELSEPKARLLLRFLRSRQKPGEVLSAVRATSRGSRRTTTRDQLVRLL
                     RDAAAIELAVMLQYLYAAYSVPTHGAGAEYVRRGLWTPGQLRLACGDGGETLDEGIRSM
                     LTDIAREEMIHFLLVNNILMAVGEPFHVPRVDFRTVNHELAVPLDFSLERLGPGSVDRF
                     VRIERPEGLVGEVRRGDGPAAPAAYDERHPYGSLSELYADLREGLQSVPDLFTVDRGRG
                     GGEHHLFLRRSLNRTHPDYQLEVDDLASALFAVDVITEQGEGGVLGPRDGETSHYHAFL
                     RISELLRSAPTDGPHPGAERWNPAYPVVRNPTLGPGDPAMETVTEAGARAVMKLFNRAY
                     FMALQLMAQHFGECPDAALRRSDLMNASIDMMTGLMRPLAELLVTMPSGRRGMTAGPSF
                     ELPEQPMAVSRPDVARRGIARRLDDLAAECGKHPLVPARVGEMSAFWADHFRPPGR"
     gene            complement(13312..14826)
                     /locus_tag="DDQ41_RS30700"
                     /old_locus_tag="DDQ41_30700"
     CDS             complement(13312..14826)
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890956.1"
                     /locus_tag="DDQ41_RS30700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30700"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_109297393.1"
                     /sec_met_domain="DAO (E-value: 2.4e-10, bitscore: 38.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPLQDSDGPDGAIGGPKKVTVIGAGIAGLVTAYELERLGHDVQ
                     IIEGSREVGGRIHTHRFAGAGEAGPFAELGAMRIPAGHRLTMHYIAELGLQNQVREFRT
                     LFSDDAAYLPGPTGYLRVREAHDTLVDDFAAGLPSAHYRQDTLLFGAWLDASIRAIAPR
                     QFYDGLHNDIGVELLDLVDHIDLTPYRCGTAHNRIDLHAFFADHPRIRSSCPLRLERFL
                     DDVLDETSSSIVRLRDGMDALPRRLAARIRGRISLGREVVGIDVRDDAVDLRIRQGATT
                     VTRTCDYVVCTIPFTVLRRMRLTGFDQDKLDIVHQTKYWPATKIAFHCREAFWEKDGIS
                     GGASFTGGHVRQTYYPPADGDPALGAVLLASYSIGPDADALARLGEAERNALVTRELSV
                     MHPELRRPGMVLGVAGRAWGARRWSWGAATVRWGQEAALREAERREAARPQRGLFFAGE
                     HCSSKPAWIEGAIESAIDAAHEIEWYEPRARGVFAAARPSRSERSA"
     gene            15224..16483
                     /locus_tag="DDQ41_RS30705"
                     /old_locus_tag="DDQ41_30705"
     CDS             15224..16483
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_28"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003958519.1"
                     /locus_tag="DDQ41_RS30705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30705"
                     /product="glycosyltransferase"
                     /protein_id="WP_245990876.1"
                     /sec_met_domain="Glyco_transf_28 (E-value: 7.9e-07,
                     bitscore: 27.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="MGT (E-value: 6.4e-38, bitscore: 129.5,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEVACELTRRGHEVRWYTGRAFRRQVEQTGAHFEPMHPEVDFGG
                     SSREEAYPDHAGLSGLANFKTGVRDIFYRTAPRQMGDLLAVLRRFPADCVLADDMCYGA
                     CFASERTGIPLAWLANSVYILGSRDTAPLGRGLGPSSSRLGRARNALLRFVSDQVVMRD
                     LRREADRVRASVDLPRLNTPAMENIARPPALYLLGTVPSFEFPRGDLLPGTHFVGPLLG
                     LPPEDFDPPAWWEDLHGGRPVVLITQGTTANDVEGMLVPAVRALADQDVLFVVTTGTDL
                     DVDRLRPLPDNVRLERFIPYHHLLPHVDVMVTNGGYNGVNAALAQGVPLVVVPGSEEKP
                     DVAARVKWAGAGVVLERPVSRAGLRDAVATVLHDGGHRRRARALAREHQGCDAPRRAAD
                     LIESMADSQGQIPTGGGITR"
     gene            16480..17700
                     /locus_tag="DDQ41_RS30710"
                     /old_locus_tag="DDQ41_30710"
     CDS             16480..17700
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890958.1"
                     /locus_tag="DDQ41_RS30710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30710"
                     /product="cytochrome P450"
                     /protein_id="WP_245990835.1"
                     /sec_met_domain="p450 (E-value: 3.5e-12, bitscore: 44.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTRTDLKEAPETSMPVDPGPFDCMPELLAAARVAPVVRIPYLG
                     EHAWVVCDPELVRTALAHPRMAKDITLVPDFMRRPGLMVGSQPPPEYARAMIMSDGADH
                     ARIRRVHQPVLSPRNTEKWGERVGVKVGGFLTELEQSRSAGSAGVDVVTDYTHRVPLAF
                     ISEMLGLPLEAERRLRSITDVMLYSSDYPARREAVGALFGAVEGWVKDPAPLREGVITG
                     FLAAADGPDAVTEGEVVVWTVGMIITGYETTGSLISASLYEALRRPPEERPQSEEDIRG
                     WIEEALRVHPPFPHPTWRFPTEDIDLGGYLIPKGAPVQVSIAAANRGPDEGADSFEAAR
                     AGHGHLSFGLGMHYCIGASLVRLEAQIAVREFLRRFPKARLTGEDAVVWESEWMIRRLS
                     TLPAVLN"
     gene            17901..18965
                     /locus_tag="DDQ41_RS30715"
                     /old_locus_tag="DDQ41_30715"
     CDS             17901..18965
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381998.1"
                     /locus_tag="DDQ41_RS30715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30715"
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="WP_109297395.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3e-12, bitscore:
                     45.6, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVLAGGSGSRLRPITHTSAKQLVPVANKPVLFYGLESIASAG
                     VREVGIVVGDTAAEIEAAVGDGSRFGLDVTYLPQEAPLGLAHAVRVARDYLGDDDFVMY
                     LGDNFIVGGIGTLVDRFRANRPDAQILLTRVSDPRAFGVVELDDGGRVTGLEEKPEHPK
                     SDLALVGVYMFTARVHDAVDRLEPSWRGELEITDAIQELIDSGCRVESAPVSGYWKDTG
                     NVADMLEVNRLVLDGVETDCSGEVESSELVGRVVIEKGATVTGSRIVGPAVVAAGARIH
                     NSYIGPFTSIDSGCSVVDSEVEYSIVLRGASIAGVRRVERSLIGREVEVTSSPRALRSH
                     RLVLGDHSKVQVAS"
     gene            18962..19915
                     /gene="rfbB"
                     /locus_tag="DDQ41_RS30720"
                     /old_locus_tag="DDQ41_30720"
     CDS             18962..19915
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009225 - nucleotide-sugar metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-171). E-value: 1e-15.
                     Score: 49.5. Matches aSDomain:
                     nrpspksdomains_DDQ41_RS30720_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056954.1"
                     /locus_tag="DDQ41_RS30720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30720"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_109297396.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 9.9e-27, bitscore:
                     92.2, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5.8e-16,
                     bitscore: 56.9, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1e-13, bitscore:
                     49.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILVTGGAGFIGSHFVRSFAGEDELTVVDKLTYAGNPAGLAAVE
                     DRLTFVHGDICDAALMAEVVPGHDAVVNFAAESHVDRSIAGAEEFVRTNVLGVQALMQA
                     CLDAGVPRIVHVSTDEVYGSIDSGSWDETAPLSPNSPYAASKAGGDLIALAYARTHGLP
                     VSITRCGNNYGPYQYPEKVVPLFVTNLLDGLTVPLYGDGTNVRDWIHVADHCRAVRLVA
                     DRGEPGEVYHVAGTAELTNLELTARLLDALGADPRLVERVPDRKAHDRRYSLADAKLRA
                     LGYAPSTPFDKGLAETVEWYTTHREWWEPLKRRGTP"
     aSDomain        18974..19474
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DDQ41_RS30720_NAD_binding_4.1"
                     /evalue="1.00E-15"
                     /label="DDQ41_RS30720_NAD_binding_4.1"
                     /locus_tag="DDQ41_RS30720"
                     /protein_end="171"
                     /protein_start="4"
                     /score="49.5"
                     /tool="antismash"
                     /translation="VTGGAGFIGSHFVRSFAGEDELTVVDKLTYAGNPAGLAAVEDRLT
                     FVHGDICDAALMAEVVPGHDAVVNFAAESHVDRSIAGAEEFVRTNVLGVQALMQACLDA
                     GVPRIVHVSTDEVYGSIDSGSWDETAPLSPNSPYAASKAGGDLIALAYARTHGLPVSIT
                     RCGN"
     gene            complement(20190..22904)
                     /locus_tag="DDQ41_RS30725"
                     /old_locus_tag="DDQ41_30725"
     CDS             complement(20190..22904)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890961.1"
                     /locus_tag="DDQ41_RS30725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_30725"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_262508627.1"
                     /transl_table=11
                     /translation="MRGREKQLARTGAQLRRVARGGRSAVLLVEAAPGAGKTRFLAEAA
                     KLADADGFAVVDGTPAGSDAAIEAARTRLRHADGIRTAVVLDDLHLASRPALTALRDLV
                     VALRGLPILWMIAFSTDRGDPLHEPLKDCLGSLRAGLPVEDVGELGPIEGEALVRLVAD
                     CTGAAPDPALLALAESVNDTPRAVIDLMRGLAEDDLCVVDGTSRLQLGPPGAALLGGGS
                     PAPVPKRFSVLIQQDLRSLSEPTLKALRLAAVLGSPFAPEDLSALLGEAPAGLLTAVDE
                     AVDRGLLVCGEHDLAFRTEPIWRVLLDSVPPPVCALLRRQAAKMLLPRPDGVERAALQL
                     VHVAQPGNAEEIRVISDGARKLLAADPSTAASLATRCMELLAPGQAERLRLARTAVEAF
                     TKAGHLERAIALARAAIDDAAPLAPPLPAEFAEDVAALKAAMSTALLLLGNVQSARRAA
                     GDALAARRAGSQHREAVIAHLAASYLTGDGTAMDRAQQILDAPDRHTRAVVVGAMTFRA
                     FGQWRDGEVGQAVSTLREAVALDLTSEEEQMLDPRWFLAFALTRTDEYEQAAAVVRGSA
                     DTSAPVTGALTTAVPAVLRAQLHLAQGRLDEAEAEARAGVGTDGRRIPMLAPQAWLVLA
                     SVALRRGALTQAEEHVGALKKHFPQHVSSPWWAARLLMNARLAEAQAGPLAAAEVLAEL
                     GAQAGALREAVMEDPAAAAWCVRSMLAADRPDLVEMVIGTTQDVLVRNPRLPSVLATAL
                     HARALAEGDPEALARAGRLHRNPWAQAAAAEDHAALLLDRGDHGNAISELDRAMSAYGA
                     LGGERDAARVRARLRGLGVRRRHWQHAKRPLSGWESLTRTERKVAELVAGGLTNQQAAR
                     HLFISPHTVGFHLRQIYRKLGIRSRTALIRLRA"
     misc_feature    complement(21627..21629)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(23002..23016)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 21.84"
                     /tool="antismash"
     misc_feature    23025..23041
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.42"
                     /tool="antismash"
ORIGIN
        1 tcctgactcc ggttcaggga cccgaggccg aagggtccgc cgtgacgggc ggctccggcc
       61 cgtagcggcc ggtgacgccg ggcagcggtc ggggcaggag gacgcggtgc cgggaaggcc
      121 gggtccggcg cctgcctgaa ctcctcctgc gccggcctcc aagccgctca cgatcagtag
      181 ccgttgtgag tgcgggtcac ggcgaaccgg aactcgttcc aagcatgcgg cgcgggtggt
      241 ctcgcgcacg gggatgccgg cgcggtcgcc ggcccggagg aaacggccct tgccggtgac
      301 gtggttgccg gggccggtcg cgatcctcgg cgccgtcgcc gggtccgtgc ccgccccgat
      361 gtccgaactc accgggggcg gcccggccgc cgcccgcgcc cgcagccgca ccggcgggcg
      421 gcaacccgaa cccggacccg ccgggtcgga ctcgtccgcg agcgagaccc ctggccgaag
      481 cccaccggta cggggcgctc ggcggtggtc cgttcgttcg gctgaagcgg gccgtggcgc
      541 ggtcacccct cgccggacgc cgcctcgccc cggtcgcccc ggaccgtgtc gacgagggcc
      601 accgggtccc ccgggaggtc gtcgccgcgc catgccacgt ggccgtcggg gcgtaccagc
      661 acgaaggagc gctcgtacag cttggcgatc tccgggtcgc cgccccggtg cacggtcagc
      721 gggacccccc gctcggcgaa cgcgcgctcg aacgccggaa ggccgtcgtg gtccgcgaag
      781 cggagcagta cgaagccctg gccgaacagg tcgagcgtgg aggtggaggc ttcccaccac
      841 gcgtgcgcgg cgcggtggcc gggctcgctg ccgggccgcc agtcggcgtc tggccggcct
      901 tggcggatcg gtacgccggg gtcgtcgacg atcgccgggg agcggtagcg cagtccgaag
      961 tggatctgcg gggcgtcgaa ctcccgccgc gcgccgctgc tcgccagccg ccccgccatc
     1021 tcggtgcggg cccgctcgcc ctcgggcccg tccaggtgga tcccgggcgg cagttccctg
     1081 ctcatggtgc gttgcaggtt ggtgttggcc tcgttgaggc tctccagggc gatcggcctg
     1141 cgctcggtgt cgtaggtgtc gagcaggtgc cgacccgccc agccgttcag tgtggcggcg
     1201 agtttccagc ccaggtcggc ggcgtccgcg atgccggtgt tgagcccgaa gccgcccgag
     1261 ggcgacaggg tgtgcgccgc gtcgccggcg aggaggacgc gcccggcccg gtaccggtcg
     1321 gcgacccggt gggtgaggtg ccactcgctg tcgccgagca cttccaccgg cgtgtcgaag
     1381 gcgagggcat cgtggatcag ggacagcgcg tcggcacgcg ccccgcggtc gccgtccgcg
     1441 cccacgacca ggttgtagag gtcgccgccg ttcagcgagc gcatggggaa gcgcagcgtg
     1501 gacgacagca tcaggaagta cacgagggcg gcgcggtcgc ccagccgttc cctgagttcg
     1561 ggggcccgga agaggacgtt gcggaagacc tgtgtgcggt ggcggcccgg cgcctcgatg
     1621 ccgcaggccc ggcggatggg agaagaggcg ccgtcgcagg cgaccaggaa gcgtgcccgg
     1681 acggtgccgg tcctgcccgt ggcccggtcg gtcaggacgg cttcgacgtg gtcatcggcc
     1741 ggcagtacgc ggtcgacggt ggtgaggagc cgcagcgggc cggccgggtg gacgcccagc
     1801 gcccgcgaca gcaccgggct cagccagtgt gcgggacaga tctggtcggg ctcgggagtg
     1861 tgcacgaagg ccggccggct cgcggcggtg ccgcggcggt accggtacac ctcgtgaccg
     1921 cccaccctgg tgacccaggc gatgtccaga gggtggtcgg cgggccagcc cgccccccgg
     1981 acggcgtccg cgacgcccca gcggcggaac agttccatcg agcgcggacc gatcgtgctg
     2041 accttgggat gccggacctg tccgtcaccg gcgtcgacga ccatgcagtc gatcccgcgg
     2101 tacgtcaggt ccagtgccac cgccatcccg accgggccgc cgcccacgac cagcacgtcg
     2161 gtccgctcgc cggagtacgt catctcgttc ctgcctctcc tcgtggatcc gtgctgcgcg
     2221 ttcggctcac ggcccgtccg taccgcgcgg ggagggtgcg cgggtgcacc ctccccgcgc
     2281 gcacccggtc aggggcgttc ggcggtgacc agcaggcagc cgaagtcgtc ggctcccgcc
     2341 aggtcggacg gcttgaagga gtcgtcgccg aagtcgaagt tgccctcgtc catggccgcg
     2401 gggcgctcct cggcggccgc cagcttcccc agttcgtcgg cgaggcgcag cgtggtctgc
     2461 tcggtgacgt cgaggatctc gcgcagccgc aggccggagc ggtggagcag tgcgacgtag
     2521 tcgtcgatgt cggccgtggt cgacatcagg tcgcggcaga acttgtcgat gcccgggtgc
     2581 cgcaccgcct ttcgcgggtg acgttcgaac acgtcggtca ggacgatccg gccgccgggc
     2641 cggagcaccc ggcacacctc ggtgaacacc cgctgccggt ccggcatgtg gcagacggac
     2701 tcgagggcca tcacggcgtc gaacgacgcg tcctcgaagg ggagccgcat cgcgtcgccg
     2761 tggcggaaga tggcacggtc ggcgagcccg gcctcggccg cgagccgtcc cgcggtcctg
     2821 atctgctcct cgctgatgct gatgccggtg acccgcgcgc ccgtgcgcgt cacgacccgc
     2881 agaccggggc cgcccacccc gcagcccagg tcgaggacgt gggaggagcc gtccaccctc
     2941 atccgctcga tgaagacgtc ggtgagccgg tccatcgcct cctcgaccgt ggcctctgag
     3001 tccggtgtgt cccagtagcc gatgtgcacg ttggggttga aggttccgtc gctcatcgcg
     3061 ctcagcgtca gccggtcgta cagcttgccg acggcttccg gctcgggcag ggtctggacg
     3121 gggtcggtca tggagacggc ctctctggtc ggcaggtgaa ggtgaaggtg cgggtgcagt
     3181 tggtgggtgg gcgggcggtc cgcggccccg gccggccacg gcgttgcggt gggccggcaa
     3241 ccgggctcga gcgccggtca ggcaccacgc gttcgcgtgg gacccgcgtc cgccgcgtcc
     3301 gggcggatgg gccggacgcc gggcgggccg atgcgctccc ggccgccccg cgggacacga
     3361 accggcggcg ggcgcgcggg cgttaccgta cgggcctcgc gggtctctcg ggcgccagcc
     3421 ccctctcgat ctgccggcag cgggcgtagt ccggcagcag gccctgccgc tgcgcctcgg
     3481 cgagggtgat cgccgcacgg tcccgctcgg agaggaccgg ttcggtgtcc gtggtgatcg
     3541 gcagtgcgag ggccgggtcg aggacggaga gggagagttc gttctcggcg gcgtagcact
     3601 cggagagcat gtaggacatg acggtgtcgt cctccagcgc cacgaacgca tggcccactc
     3661 ccacgggtat gaagctggcc cggtggtcgt tctggtccat cagcaccgcg tcccagcggc
     3721 cgaacgtggg tgagccgacc cggatgtcga cgacgatgtc cagcgcgctg ccgcgggagc
     3781 agtggacgta cttcgcggta cccggcggtg tcaccgtgta gtggatgccg cgtacgacgc
     3841 cgcgccggga cacgctgtgg ttggtctgcg cgacggggaa gagcggggcg ccgtgggcct
     3901 cggtgaacgc ccgctcctgg tacggcgaga cgaacctgcc ccggtcgtcg gggaagacgc
     3961 ggggcgtgaa ctcgatggcc ccctcgacgg tgagtgcgcg tgctttcaca tcttctccct
     4021 cggctcgctg gtcggttcgc tggtcggttc ggtgctcggt tcggcggaac gcggcgggcg
     4081 gctgggcgtc acagcgtccc cagcacctcg cgcagggcat ggatgacctt gtcctggaga
     4141 tcgggggcga gtgaggggta catcggcagc gagaagatct cgccggccag cgcctcggtg
     4201 accggaagcg accccttggc gtacccgagg tgggcgaagc cggtcatggt gtgcaccggc
     4261 cacggatagc tgatgttgag gtggatgtcg tacgccttga gtcgctcgat gatgtcgtcg
     4321 cgcctggggt ggcggaccac gtacacgtag tacacgtgct cgttgccggg cacggtccgc
     4381 ggcaggacga ggccggtgcc cgccagaccg tcggcgtagc gccgggcgac cgcccggcgg
     4441 ccggcgatgt aggtgtcgag ccgtcccagc ttgcggcgga ggatctcggc gtggagctcg
     4501 tcgaggcggc tgttgtgggc gggggtctcc agggtgtagt agcgctcgtc catgccgtag
     4561 tagcgcagtc ggcgcagccg tttcgccacg gaggggtccg aggtgatcgt ggcgccgccg
     4621 tcgccgtagg cgccgagcac cttggtcggg tagaaggaga aggcggcggc gtcaccggtg
     4681 gagccggcca ccgtcccgcc ctgcctggcg ccgtgggctt gggcgcagtc ctccaggacg
     4741 gccagtccgt gccgggcggc gagttccttc agcgggccca tgtccacgca ctggccgtac
     4801 aggtggacgg ggaggatgca ccgggtgcgt ccggtgacgg ccgcgccgac ctggccggtg
     4861 tccatgaggt agtcgtcctc gcggacgtcg acgaagacgg gagtggcacc ggtggagtcg
     4921 atggcgacga cggtgggtgc cgcggtgttc gacaccgtga tcacctcgtc gccggggccg
     4981 atgccgaggg cctggagtcc cagcttgatg gcgttcgtcc cgttgtcgac gcccacgcag
     5041 tggtccaccg agtggtaggc ggcgaactcc tcctcgaagc cgcgcacgct cgcgccgagc
     5101 accagccggc ccgaggagaa gaccgtctca acggcgtcca ggatgtccgg gcgctcggcc
     5161 tcgtactccg ccaggtagtc ccatacacgc gtcgtcatct tccagccttt ccagaacggc
     5221 ggcgcactgc ggtgcgcctg cggtcggtgg gtgtcggggg tgcggtcacc gggggtcgtc
     5281 ccgcccgcgg gccagggcgg tcacggcgcg gcgcacgcct tcgtgcagcg ggatccgggg
     5341 atgccagccg gtggccgcgc ggaacgccga ggagtcgagg gtcacgctcc ggaagtccgt
     5401 cgcgggggcg tgcgcgggtg gttcgacgga caccacgtcg accggaggcc gtcccagtac
     5461 gtcggccgcg gtgcgggcga ccagccggaa gacctcgccg agcgcgtcgc cgcggcccgc
     5521 gccgatcagc cagtggccgc ccaccaggga gccggggtgg tccagagcgg ccgtgaacgc
     5581 cgccgcgacg tcgtcgacgt ggaccaggtc gcggcgcacc gtgccgtcgt gccacatggt
     5641 gagcgtccgc ccgtcgagcg cccgccgcgc catggcggac acgacacccc ggtcgcccgc
     5701 accgggcgcc gcgctctcgc cgaacaccgt gggcagacgc aggctgacgc cgcgtacccg
     5761 gccctcggca gtggccttca gcaggtgctg ctcggcggcc agtttctgcc ggtcgtaggc
     5821 ggtctcgggg cggtcgggtt cggttccgtc gagcggctcc cgccggggca ccccgacctg
     5881 cgaggcggca ccgccgtaca cgaccagcgg gggcgtcacc tcgcccgggg ccggccgcag
     5941 cacgtcgacg aggtcccgca tgaccccgac gttgacgcgc tcggcgccgg ggtcgctctc
     6001 ggcggcccgc cagccgccgt cccccagcag cagatggatc accgcgtccg agcctgcgac
     6061 cgcttcggcg agggcctccc ggtcggtgag gtcggcggtg acgacggtgg tctcggcctg
     6121 gccgggagcg ggtgtgctcg gcctgcgcgc aacggcccgc agccggatcc ggcggttcgc
     6181 cagcgcgcgg gtgacggacg atccgacgaa gccggaggca ccgagtacgg tgaccagggg
     6241 tgtgcgcttc actgcgctcc tcttctcgat gtcagcggtg cccgcctcca tggagcagcc
     6301 ctccccggga ccgcgccgcg gcggcgttga ggcaggccag cagcgtgcgg gcctcgacgt
     6361 tcaggtagtg gccgtgccgg gtgagggccc tgagctgggc cggggcggcc cagatgtagg
     6421 cggggggcgg ttcgagcggg gcgtcgccgg cctcgacgac gaggtaccgg cttctcgcgt
     6481 tgaggaagcg cccgccctcc tcggacagga cggcctggta gcggacctgc gacggcgggg
     6541 cgttgagcac ggtgtcgagg aacggcgggc ggtccgccgg gggcagatgg gcgtagttgc
     6601 cgggtgtgca ctggacggtc ggggccagct cgacggtgtc caggaagccg ccctcggccc
     6661 gggcgtgcac cagcacatgg gggactccgc cgatctcgcg taccaggaac gcggcgaccc
     6721 ccagccccac gggctcgacc aacggctggt cccagtggac cacttcgcgg ctgccggccc
     6781 gcacggagac ggcgacgacc ctgaagtagc gcccgtcctc gtgctcgatc gcctcggcgc
     6841 cgcgcttcca gccgcgcacg tcggcgagcg gtatccgttc ggcgcgcacg tcgcggcggg
     6901 agcgctcgcc cgtgaaccag gagaggagct gcgcgtccga cagcagcgcg cctggggacg
     6961 tgtccccgta cggcacgcac gacagcacgg tcctggcgtt catgttgacc atgtcgtcct
     7021 cgtggagcag ttcggcgatc tggccgaggg tgagccagcg gaagtcgtcc agctcgggga
     7081 cgtcgccggc ggtctccacg atcatgttgc ggttggtctt gcggtagaac cacgagccct
     7141 gctcggactg gaggacgtcg acgacgacgc ggtccgggtc gggccgcagg aagtggtcga
     7201 cgagctggac ttccgcaccc cggtgggccc tggtgtagtt gctgcgggtg gcctgcacgg
     7261 tcggggagag ctggagcagg ttggcgttgc ccggctccat cttggcctgc atcaggaagt
     7321 gcagcacccc gtcgaactcc ttggccagga tgccgaggat gcccacttcg ggctgtctga
     7381 cgaccggctg ctgccactcc cggtacgggc cgtcgccgaa gggcccgccg gactccacca
     7441 catgcatgcc ctcgacggtg aagaaccgcc cgctgcggtg cacgagattg ccgctgcccg
     7501 gctcgaagcg ccactggccc agctccgcga acggtatccg ctccacgtgg aacacgtggg
     7561 cccggcgacg ctcggccagc caggcgcgca cgtccccggt ccgcgcccgc gcccctcgcc
     7621 cggtcgcggc cgacagggcg atgcggtcgg ccaaccggcc gtcctcgcgc gggcgtacgg
     7681 ccggaacggc gggcggtggc acgatccgag acgacatcga gggctccctg ccgctcagga
     7741 ccgctgcgcc gtgatcagga catagccggt gtgcgggtgg ctccccacgc cctccatcag
     7801 gtcggccgcc gcggccatct gctccgccgc gccggagtcg agggactcgg cgagttcccg
     7861 gaaggccgca gcggcgtgcc cgtagctggc gcggacctgc tcaccgatgt ccgtcagctc
     7921 cagtagttcc cagcccgcgg ccgccagatg ggcgcggtgc tcctcgggcg tgttgatccc
     7981 ggcgatctcg tacatgcgca gcatcccgtc gagtacggcc ctgtcgccac cgctgaacgg
     8041 ctgccgcagg cacaggtcgg cgacggcgag ccggccgccg ggccggacga ctcggtggag
     8101 ttccttcagc gcgcgggtct ggtcggccat gtgcagcagc gactcgatcg cgaaggcacc
     8161 gtcgaaggag ccgtcgtgga aggggaggtc ggtggcgtcc gccagccgga aggagacccg
     8221 gcacccgagt ccggccccca ccgcccgctc cgccgcctcg gcgacctgct gcccgctcac
     8281 ggtgatgccg gtgacgtgca cgtcgtgcgc ctccgcgacg cgcagggccg gtaccccgat
     8341 gccgcagccc acgtccagca gccggcggcc cggccggagg tcgaggcggt cggcgaccag
     8401 gtcggtgaga cggtcggtgg cttcggcgag cgggacaccg gggtcgtcgt cccagtagcc
     8461 cacgtggatg ttgccgccca tggccgtggt ggccccggcg tcggcgaact ggtcgtacac
     8521 ctcgcccacg gagtcggcgg tggtgtcgga cttctgcgtc atggctgtgc cttcctgttg
     8581 tgcgtcgtcg atgccgcgct gcgggtcacg gaaggtcgga caggtcgagg accagccggg
     8641 tcgggccgtg gaagaccagg tcgtcggcgt actcgacccg gtggccgccg aggccgagtc
     8701 cggggatccg gtccagcagg gtcccgaggc cgatctcggc ctcggcgcgg gccagcgtcg
     8761 cgccgaggca gtagtggatg ccgaggccga agcccaggtg ccggtcggct gcgcggtgga
     8821 cgtccaggac gtcggggtcc gggaagcgcg cggggtcccg gttcgccgag cccagcaggg
     8881 ccaccacgcg gctgccgcgc ggcacgtcgt ggccgccgag gtgcgcgtcc tcgtacgccc
     8941 agcgcgtcac cgcctgcacc ggcgggtcgt agcgcatcag ttcctcgacc gcggacggcg
     9001 tcagccgggg cgcggcacgc agctccgcca ggatctcggg gtgcgcccgc agggccagca
     9061 cggccttggc caggaagttg gtggtggtct cgtgtccggc ggtgagcaga tggacgcacg
     9121 tcccgacgat cccgtccacg gtcagccgcg cgccggagtc ccgggcccgg acgaggaggg
     9181 tcagcaggtc ggcaccgtcg cccccgctcc gccggtccac ctgctgccgg aagtagcgcg
     9241 cgaactcccg ggaggccgtc tcggcccggg cgtaaccgcc ggcgccgcgc gaacgggtgg
     9301 tgctggcctc ctggagggcg accgcgccgg cccggagcca tgcgcggtcc tcttcgggga
     9361 ggccgagcag ttcggagatg acgaggacgg ggaagggcgc ggcgaagccc tccacgaggt
     9421 ctgcctcgcg gtgccctccc agccgttcca cgagttcgcg tgcgagccgg gtgatgcgcg
     9481 gccggagatc ggtgacgatc gagggcgaga accgggtgtt gagcagggag cgcagttcgg
     9541 tgtggcgcgg cgggtccagg aagaccagcc agttctcgac gatggtccgc agggcccggt
     9601 gttcggcggg gaccgggacg ggcgccgcgc gggtgccggt gtcgccggac gccgcgcggg
     9661 cgctgcgtcc gaaccgccgg tcggacagga cgcggacgac gtcgtcgtag gcgaagaggt
     9721 agaaggtgtc cgggccgccc gcgcccgacg cggtgcgatg gaccggcgcg gcctcccggt
     9781 agcgccggta cacggggtac gggtggctga tgtcctccct ggcccagccc gtgaggtcga
     9841 accgcggcag tgtcgcgcgg ggcatgcggt ctccttcggt cggtggtgcg gtggtgcggc
     9901 ggcggggcgg tgcggcggtg cggtggcgcg gcatggggac ggtgcggcgg tgcggctccg
     9961 ggggagtgcg gccggggcgt cctccggccg cgggccggcc ctagcggccc ggtggccgga
    10021 agtgatccgc ccagaaggcg ctcatctcgc cgacgcgcgc gggcacgagg ggatgtttgc
    10081 cgcactccgc cgcgagatcg tccaggcgcc gggcgatacc gcgccgggcc acgtcggggc
    10141 gggagacggc catcggctgc tcgggcagtt cgaacgacgg tccggcggtc atgccccggc
    10201 gccccgacgg catggtcacg agcagttccg ccagcgggcg catcaggcct gtcatcatgt
    10261 cgatcgacgc gttcatcagg tcggaccgcc gcagtgcggc gtcggggcac tcgccgaagt
    10321 gctgggccat gagctgaagc gccatgaagt aggcgcggtt gaacagcttc atcaccgccc
    10381 gggcgccggc ctcggtgacc gtctccatcg ccgggtcccc cggaccgagg gtcgggttcc
    10441 gtacgacggg gtaggcgggg ttccaccgtt cggcacccgg gtgcggcccg tcggtcggcg
    10501 cgctgcggag cagctcggag atccgcagga acgcgtggta gtgggacgtc tcgccgtccc
    10561 gcgggccgag tacacctccc tccccctgct cggtgatgac gtcgacggcg aacaacgcgc
    10621 tggcgaggtc gtctacttcg agctggtagt cggggtgcgt ccggttgagg gacctgcgga
    10681 ggaagaggtg gtgctccccg cctcccctgc ccctgtccac cgtgaagagg tccgggacgc
    10741 tctgcagtcc ctccctgagg tccgcgtaga gctcgctgag cgaaccgtac gggtgccgtt
    10801 cgtcgtacgc ggcaggggcc gccggtccgt cgccgcgccg tacctccccg acaaggccct
    10861 ccggacgctc gatccgcacg aaccggtcca cgctgccggg ccccagccgc tccagggaga
    10921 agtcgagcgg gaccgccagc tcgtggttga cggtgcggaa gtcgacgcga ggcacgtgga
    10981 acggttcgcc caccgccatg aggatgttgt tgacgagcag gaagtggatc atctcctcgc
    11041 gggcgatgtc cgtcagcatg ctgcggatgc cctcgtcgag ggtctccccg ccgtcaccgc
    11101 aggcgagccg gagctgcccg ggcgtccaca gcccccgccg cacgtactcg gcgccggcgc
    11161 cgtgggtggg caccgagtag gcggcgtaga ggtactggag catgacggcc agttcgatcg
    11221 cggcggcgtc gcgcagcagc ctgaccagct ggtcccgggt ggtggtccgc cggcttcccc
    11281 ggctggtggc acgcaccgcc gaaaggactt cgccgggctt ctgccgggac cgcagaaacc
    11341 tcagcaggag ccgcgccttc ggttcggaga gctcccgtgt gggcggcatg tagtaggtct
    11401 tcgacttgtt gcgcggatcg cacatctgcc agatcagctt ggcgtacgtc tcgaccttgc
    11461 agcggtccgc gaggctgaag acctccgcct tcatgaacga gtacgtgtgc tcgtagaacg
    11521 cgaagacctc ctcgtacacc aggtcgaagg acacctcgtc ctcgtcctcg tcctggtccc
    11581 ggtccgtccc ggccagccgc cagtcgtcgg gcagcacccg caccgccaga tacccggcgc
    11641 cgggccagta gccgagggtg tcgccgtggt cgtagcccag cgcggcggag ccgggccggt
    11701 ccgggtcgca cggcaggtcg tccgggccgg tggacagcag gacccgggcc gtcccggacg
    11761 ccgcgccccg cagggtgaac cagccccggc cctcgtcgtc cgtgtccaga acacacgtgc
    11821 tcgaccatcc accgccaccg ccaccgccat cgccaccgcc atcgccaccg tcccgccgtc
    11881 ccgcacgcac ccggacgacg ccgacgtccg agcaccgcgc gtcgggggac gccgcgaccg
    11941 ggtcacgggg cagggcccgg gggttgaaga actgccgcac gccgatcccc ccgacggcgg
    12001 ccggccggcc ccgtacgaag gaccgcacga gcacctcggc gtcgtggtcc gggtcgtccg
    12061 cgtccctggg gtgctccagg atgagggccg cgtcgtcggc ctggacgttg acctccttct
    12121 cgcgcaggtg caccacggga ccgccggggc cggtaccgac caggtgcagc gcctcctcgg
    12181 cggcctccct cgccggcatc tcgacgggga ccgtcaccag gccgccggcg agggcgtacg
    12241 cctccccgag ataggtctgc cggggcaccc gggcgaccag ccgaccgctg tccgccgtcc
    12301 gcagctcgag atcgcccatg tcgaccggcc gggcctcggc ccggccgtcc cgcaccgggc
    12361 cggagacggg catcgcggtg atcatgttga gcatggcgtg gtcgtccgtc agatgcacgg
    12421 tgaggttgtg cggtcccccc ggcccggggc ggctcgggac gagcagacgg cccgccgggt
    12481 aggtgcgcgg ctcgcacggc cgccagggag cgatggttcc gcgcagccgc cagcggcccg
    12541 ggcggtcggg ggcctcgggc gcggacgcgt ggccgagcgc gaactgcacg accagccctc
    12601 ccgcttcccc gcaggccacc gtgtcccgca ggcgccgtac ggccggtgag acggccgcct
    12661 cgtcgagcca ggccggctcg ccgtccccgg cgacgacgaa ctggtggacc acggaccggc
    12721 gcagccgctt ggccagccag tgctccccga cgtcccgcac atggtgggtg ttgtgccacc
    12781 tcggggggtg gaaaccgtgg acgtcgccgg tggccatgta gccgacgtcg tgggagcggc
    12841 cgtcgcgccc gaagcagaac tgtccgacca tgagggtcgt cgtccagtcg gaggccgggt
    12901 cgacgtcgaa gacccgcgcc cggttgaccg tggtgccgag gtactcgttg tagtgccccc
    12961 acatgtccac ggcgcgcccg atcaccggat ccccggtgtc cggctcgccc gcgcggcact
    13021 cgaccgcggt gatccgcgcg tcgacggcga agtgcccgtt gccggcgaag tcctcgccct
    13081 tggccgcact gaaggggccg tcgtccgccg gccggccggt gctgtcgtac cgcggcccga
    13141 tcaggtcgag gtggtcgtgg tactcgcccg gcggacggtg gggcgggaag ggctgcccgt
    13201 cggcggtgag cgccgtgttc gtggccaggt cgacgaggcc gcttcgggcg ccggtggggg
    13261 catgggtggt ggcggttccg gcaaagtgca gccggggcag gtcgaagacg ctcacgccga
    13321 ccgctccgag cggctcggtc gggcggcggc gaacacgccc ctggcacggg gctcgtacca
    13381 ctcgatctcg tgcgcggcgt cgatcgccga ctcgatggcg ccctcgatcc acgcgggctt
    13441 cgacgagcag tgctcgccgg cgaagaagag gccccgctgc ggccgggcgg cctcgcggcg
    13501 ctcggcctcg cggagggcgg cctcctggcc ccatcggacc gtggccgctc cccaggacca
    13561 tcggcgtgcg ccccaggccc ggcccgccac ccccaggacc atgcccggcc tgcgcaactc
    13621 cgggtgcatc acgctgagtt ccctggtgac gagggcgttc cgctcggcct cgccgagccg
    13681 ggcgagggcg tcggcgtccg ggccgatgga gtaactggcg agcagcaccg cgccgagcgc
    13741 ggggtcgccg tcggcgggcg ggtagtacgt ctgccggacg tggccgccgg tgaaggaggc
    13801 gcccccgctg atgccgtcct tctcccagaa ggcctcgcgg cagtggaagg cgatcttcgt
    13861 cgccggccag tacttcgtct ggtggacgat atccagcttg tcctggtcga agccggtcag
    13921 ccgcatcctc ctgagcacgg tgaacggaat ggtgcacacc acgtagtcac aggtcctggt
    13981 gaccgtcgtg gcgccctggc ggatccgcag gtccaccgcg tcgtcgcgca cgtcgatgcc
    14041 cacgacctcc cggcccagcg agatcctgcc gcggatccgc gcggcgagcc gccggggcag
    14101 cgcgtccatg ccgtcccgca gccgcacgat gctggagctg gtctcgtcga gcacgtcgtc
    14161 gaggaagcgc tccagccgga gcgggcagga cgaccgtatt cgcgggtggt cggcgaagaa
    14221 ggcgtgcagg tcgatcctgt tgtgcgcggt accgcaccgg tacggcgtca ggtcgatgtg
    14281 gtcgacgagg tcgagcagtt ccacgccgat gtcgttgtgc agcccgtcgt agaactggcg
    14341 gggtgcgatg gccctgatgc tggcgtccag ccaggccccg aacagcaggg tgtcctgccg
    14401 gtagtgcgcg ctcggcagcc cggcggcgaa atcgtcgacg agggtgtcgt gcgcctcgcg
    14461 cacccgaagg tatccggtgg gaccgggcag gtaggcggcg tcgtcggaga acagcgtccg
    14521 gaactcgcgg acctggttct gcaggccgag ttcggcgatg tagtgcatgg tcagccggtg
    14581 cccggcgggt atgcgcatcg cgccgagctc ggcgaacggc ccggcctcgc cggccccggc
    14641 gaagcggtgg gtgtgaatac ggccgcccac ctcccggctt ccctcgatga tctggacgtc
    14701 gtgtccgagg cgttccagtt cataggcggt caccagaccg gcgatgccgg cgccgatgac
    14761 ggtcaccttc ttcggtccac cgatggcgcc gtccggcccg tcactgtcct gcaagggtgc
    14821 cgtcacaggt ttcctccagt acgcgaagtc cgaggccggg ctgggtggga tgaacgcggc
    14881 gcctctccgt gtcccgaagg ggcgatgccg gggattgcgc atcggccatt cttcgggtga
    14941 cgcaaccgcg tccgtatccc ccggcggacc cgggcgcgag tggttcggcg agccgtccgc
    15001 cggcgtgaac ggggcggcgt ggcggcgcca tcctgcgcga gtgcgcgggg ttttcccgcc
    15061 gccgcgatcc agccccccgg cagggtgatg ctggcgtgcg tgggcggtcg gcccccgtcc
    15121 cgcggggacc agggccaccg acgcaatccg cgagacgcct gaggaggcga tgttgacgcg
    15181 cgtgctgatc gctaccacac cggcacaggg acacgtcgtg agcatgctcg aggtcgcatg
    15241 cgaactgacc cggcgcggcc acgaggtgcg gtggtacacc ggccgggcct tccggcggca
    15301 ggtggaacag accggggcgc acttcgaacc catgcacccc gaggtcgact tcggcggcag
    15361 cagccgcgag gaggcctacc ccgaccacgc ggggctgtcc ggactcgcga acttcaagac
    15421 cggagtccgc gacatcttct accggaccgc accgcgccag atgggcgacc tcctggcggt
    15481 cctccgacgg ttcccggcgg actgcgtact cgccgacgac atgtgctacg gcgcctgctt
    15541 cgcgagcgag cgcaccggca tcccgctcgc gtggctggcc aattcggtct acatcctggg
    15601 cagcagggac accgccccgc tcggccgggg gctggggccg agctcgtcgc ggctcggccg
    15661 ggcacgcaac gcactgctcc gcttcgtctc ggaccaggtg gtgatgcggg acctgcgccg
    15721 ggaggccgac cgggtccggg cctccgtgga cctgccgagg ctgaacaccc ccgccatgga
    15781 gaacatcgcc cgtccgcccg cgctctatct gctgggcacc gtaccgtcct tcgagttccc
    15841 ccgcggcgat ctgctcccgg gcacccattt cgtgggcccc ctcctcgggc tgcccccgga
    15901 ggacttcgac ccgcccgcct ggtgggagga cctgcacggc ggccggccgg tggtactgat
    15961 cacccagggc accaccgcca acgacgtcga ggggatgctc gtcccggccg tacgggccct
    16021 ggccgaccag gacgtcctct tcgtggtcac caccgggacg gacctggacg tcgaccggct
    16081 ccggccgctt ccggacaacg tacgcctgga gcggttcatc ccctaccacc atctgctgcc
    16141 gcacgtggac gtgatggtga ccaacggcgg ctacaacggt gtcaacgcgg ccctcgccca
    16201 gggggtgccc ctggtcgtcg taccgggctc ggaggagaag cccgacgtgg ccgcgcgcgt
    16261 caagtgggcc ggcgccggcg tcgtcctcga acggcccgtg tcgagggccg gcctgcggga
    16321 cgcggtggcc accgtgctcc acgacggcgg ccaccggcgg agggcacgcg cactggcccg
    16381 ggagcaccag ggctgcgacg ccccgcgacg ggccgccgat ctcatcgagt ccatggccga
    16441 ttcccagggc cagatcccca ccggcggagg tatcacacgg tgaacaccac gaggaccgac
    16501 ctcaaggaag cccccgagac cagcatgccc gtggacccgg gtcccttcga ctgcatgccg
    16561 gaactgctgg ccgcagcgcg cgtggcgccg gtcgtccgca tcccctacct cggcgagcac
    16621 gcctgggtcg tctgcgaccc cgagctggtg cggaccgcgc tcgcccatcc caggatggcc
    16681 aaggacatca ccctggtccc cgacttcatg cgccggcccg gtctgatggt gggatcgcag
    16741 ccgcccccgg agtacgcccg cgccatgatc atgagcgacg gcgcggacca tgcccggatc
    16801 cggcgggtgc accagccggt gctgagcccg cgcaacaccg agaagtgggg cgaacgggtc
    16861 ggcgtcaagg tcggtggatt cctcaccgag ctggagcagt cgcgatccgc cgggtccgcc
    16921 ggggtcgacg tggtcaccga ctacacccac cgggtcccgc tggccttcat ctccgagatg
    16981 ctcggcctgc ccctggaagc cgagcggcgg ctgcggagca tcaccgacgt catgctctac
    17041 tcctccgact accccgcacg ccgcgaggcg gtcggcgcgc tgttcggggc ggtcgagggc
    17101 tgggtgaagg accccgcccc gctgcgggag ggtgtgatca cgggcttcct ggccgcggcg
    17161 gacgggccgg acgccgtcac cgagggcgag gtcgtcgtct ggaccgtggg catgatcatc
    17221 accggctacg agacgaccgg gagcctgatc tccgcctcgc tgtacgaggc gctgcgccgg
    17281 cccccggagg agcggccgca gtccgaggag gacatcaggg gctggatcga ggaggccctc
    17341 cgggtccatc cgccgttccc gcatcccacc tggcgcttcc ccaccgagga catcgacctc
    17401 ggcggctatc tgatccccaa gggtgccccg gtgcaggtca gcatcgcggc ggcgaaccgc
    17461 gggccggacg agggcgccga cagcttcgag gcggcccgcg ccgggcacgg ccacctcagc
    17521 ttcggcctgg gcatgcacta ctgcatcggc gcctcgctgg tccgcctgga ggcacagatc
    17581 gccgtacggg agttcctgcg ccgcttcccg aaggcgcgcc tcaccggtga ggacgccgtc
    17641 gtgtgggagt cggagtggat gatccggcgg ctgagcaccc tgcccgccgt actgaactga
    17701 cgacgtgccc accggcgtcc ttcccgcctc ccggcaccgg gaggcggggg acgccgtacg
    17761 gggcgcccgg ccccgtgccg accgccccga ggacccggcc accgggcgct cacccgggcg
    17821 gcccgggcat ccagcccttc cagacgagtt ggggagacga tgactcctgc ccttgcggcc
    17881 gacctaccgg cggggcgccg atgaaggcgc tcgtgctcgc cggcggctcc ggttcccggc
    17941 tgcggccgat cacccatacg tcggcgaaac agctcgtgcc cgtcgccaac aagccggtcc
    18001 tcttctacgg cctcgaatcg atcgcctcgg cgggcgtccg cgaggtcggc atcgtcgtcg
    18061 gcgacacggc agccgagatc gaggccgcgg tcggcgacgg atcgcgcttc ggtctggacg
    18121 tcacctacct cccgcaggag gcaccgctgg ggctcgccca cgccgtgcgg gtcgcccggg
    18181 actacctcgg cgacgacgac ttcgtgatgt acctgggcga caacttcatc gtcggaggca
    18241 tcggcacgct cgtggaccgc ttccgggcga accgcccgga cgcccagatc ctgctgaccc
    18301 gggtgtcgga cccgcgtgcg ttcggcgtgg tggaactcga cgacggcggc cgggtcaccg
    18361 gcctggagga gaagccggag catccgaaga gcgacctcgc gctggtcggc gtctacatgt
    18421 tcaccgcccg ggtgcacgac gcggtggacc ggctcgaacc ctcgtggcgc ggggagctgg
    18481 agatcacgga cgcgatccag gagctgatcg actcgggctg ccgcgtggag tcggcgccgg
    18541 tctccggcta ctggaaggac accggcaacg tcgccgacat gctggaggtc aaccgcctgg
    18601 tcctggacgg cgtcgagacg gactgctcgg gcgaggtcga gtccagcgag ctggtcggcc
    18661 gggtggtgat cgagaagggc gcgaccgtca cgggatcgcg gatcgtcggt cccgcggtcg
    18721 tcgcggcggg tgcacgcatc cacaactcct acatcggccc gttcacctcc atcgacagcg
    18781 gatgctcggt cgtcgacagc gaggtcgagt actccatcgt gctgcgcggg gcgtccatcg
    18841 ccggggtgcg gcgcgtggag cgctcgctga tcggacgcga ggtcgaggtg acgtcgtcac
    18901 cccgggccct gcggtcccac cgcctcgtcc tcggcgacca cagcaaggtg caggtggcgt
    18961 catgagaatc ctcgtgaccg gcggcgccgg tttcatcggc tcccacttcg tacggtcctt
    19021 cgccggcgag gacgagctga ccgtcgtcga caagctgacc tacgccggga acccggccgg
    19081 cctggcggcc gtggaggacc gcctcacgtt cgtacacggc gacatctgcg acgcggcgct
    19141 catggccgag gtggttcccg gccacgacgc cgtcgtcaac ttcgccgccg agtcgcacgt
    19201 tgaccggtcg atcgccggcg cggaggagtt cgtccgcacc aacgtcctcg gcgtgcaggc
    19261 cctcatgcag gcctgcctcg acgcgggcgt cccgagaatc gtccacgtct ccaccgacga
    19321 ggtgtacggc agcatcgaca gcgggtcctg ggacgaaacc gccccgctca gccccaactc
    19381 cccctacgcc gcatccaagg ccggcggtga tctgatcgca ctcgcctacg cccgcaccca
    19441 cgggctgccg gtcagcatca cccgctgcgg caacaactac gggccgtacc agtacccgga
    19501 gaaggtcgtc ccgctcttcg tcaccaacct cctcgacggc ctgaccgtcc cgctctacgg
    19561 cgacggcacc aacgtgcgcg actggatcca tgtggccgac cactgccgag ccgtccggct
    19621 ggtcgccgac cgaggggaac ccggagaggt ctaccacgtc gccggcaccg ccgagctgac
    19681 caatctggaa ctcaccgccc ggctgctcga cgcactgggc gccgacccgc gactcgtcga
    19741 gcgggtcccg gaccgcaagg cccacgaccg ccgctactcc ttggccgacg ccaagttgcg
    19801 ggcactcggg tacgccccgt ccaccccctt cgacaagggt ctggccgaga ccgtcgagtg
    19861 gtacacgacc caccgcgagt ggtgggagcc gctgaagagg cgcgggaccc cctgaggtgc
    19921 gagggcccga cggcgaaacg gggccgtgcc gaccggctgc tccgcagcgg gggtcccctc
    19981 ggcgcgggcg cgggcgcggg ggcgccaaga ccgccaagac ccgtgttggc cgtggcggtc
    20041 ttggcgcggg cgcgggcgcg agcgggggcg gaaggggagg gagggagcgc acacgaagga
    20101 gccgatgccg ccccgccacc agggggcgcc gccgcccggc gacacgaagc tgcctgccgg
    20161 acggctgtcg cggccctggg ggcgaagcgc tacgccctga gccggatcag tgccgtgcgg
    20221 gaccggatcc ccagctttcg gtagatctgc cgcagatgga atcccaccgt gtgcggggag
    20281 atgaacaggt ggcgggcggc ctgctggttg gtgaggccgc cggccaccag ttccgccacc
    20341 ttccgctcgg tcctggtgag gctctcccag ccggagagcg gccgcttggc gtgctgccag
    20401 tgccggcgtc tcaccccgag cccgcgcagg cgggcacgaa cccgggcggc gtcccgctcg
    20461 ccgccgagtg caccgtaggc gctcatggcc cggtccaact cgctgatcgc gttcccgtgg
    20521 tccccgcggt cgagcaggag agcggcgtgg tcctcggccg ccgccgcctg cgcccacggg
    20581 ttgcggtgca gccgcccggc acgggccagg gcctcggggt cgccctcggc gagcgcccgg
    20641 gcgtgcaggg cggtggcgag caccgagggg aggcgagggt tgcggacaag gacgtcctgc
    20701 gtcgtgccga tcaccatctc gacgagatcc ggccggtcag cggcgagcat ggagcgcaca
    20761 caccaggccg cggcggccgg gtcctccatg acggcttcgc gtagcgcacc tgcctgggcc
    20821 ccgagttccg cgagcacctc cgccgccgca agggggccgg cctgggcctc ggccagccgg
    20881 gcgttcatca ggaggcgcgc cgcccaccag gggctggaga cgtgctgggg gaagtgcttc
    20941 ttcagggccc cgacgtgttc ctcggcctgg gtgagcgccc cccggcgcag agcgacggag
    21001 gccaggacca gccatgcctg cggtgcgagc atcgggatgc ggcggccgtc ggtgcccaca
    21061 ccggcccggg cctccgcctc ggcctcgtcc agtcggccct gggcgagatg cagttgggcg
    21121 cggagaacgg ccgggacggc ggtggtcagc gccccggtca ccggggcgct cgtgtcggcg
    21181 gaaccgcgga cgacggccgc cgcctgctcg tactcgtcgg tcctggtgag ggcgaaggcc
    21241 aggaaccagc ggggatcgag catctgctcc tcctcgctcg tgaggtcgag cgcgaccgcc
    21301 tcgcgcaggg tgctcaccgc ctgccccacc tcgccgtcgc gccactggcc gaaggcgcgg
    21361 aaggtcatcg caccgaccac cacggcccgt gtgtggcggt cgggagcgtc gaggatctgc
    21421 tgcgcacggt ccatcgcggt accgtcgccg gtcagatagg aggcggcgag gtgggcgatc
    21481 acggcttccc ggtgctggct cccggcccgt cgcgccgcca gcgcgtcgcc cgcggcccga
    21541 cgcgccgact gcacgtttcc gagcagcagc aacgcggtcg acatcgccgc cttcagcgcg
    21601 gccacgtcct ctgcgaactc cgcgggtaac gggggagcca gcggcgccgc gtcgtcgatc
    21661 gcggccctgg ccagggcgat cgcccgctcc aggtggcccg ccttggtgaa cgcctcgacc
    21721 gccgtgcgcg ccaggcgcag gcgttcggcc tgaccggggg ccagcagttc catgcagcgg
    21781 gtcgccaggg acgccgccgt ggagggatcg gcggcgagca gcttccgcgc gccgtcggag
    21841 atgacgcgga tctcctccgc gttcccgggc tgggcgacat ggaccagttg aagggcggcg
    21901 cgttcgacgc cgtcgggacg cggcagcagc atcttcgccg cctgccggcg caacagggcg
    21961 cacaccggcg gcggtacgga gtcgagcagg acacgccaga tcggctcggt cctgaaggcg
    22021 aggtcgtgtt caccacagac cagcaggccc cggtcgaccg cttcgtccac cgccgtgagc
    22081 aggccggcgg gtgcttcgcc gagcagggcc gacaggtcct ccggtgcgaa cggcgatccg
    22141 agcaccgcgg ccagcctgag cgccttcagg gtgggctcgg agagtgacct gagatcttgc
    22201 tggatgagca cggagaagcg tttcggcacg ggcgcgggcg aaccgcctcc cagcagggcg
    22261 gcgccgggtg ggccgagctg cagccgggag gtgccgtcga ccacgcacag gtcgtcttcc
    22321 gcgagcccgc gcatgaggtc gatcacggca cggggcgtgt cgttgacgct ctccgccagg
    22381 gcgaggagag ccgggtcggg ggcggccccg gtgcagtcgg cgaccagacg cacgagcgcc
    22441 tcgccctcga tgggccccag ctcccccacg tcttccaccg gaagcccggc acggagcgaa
    22501 ccgagacagt ccttcagcgg ctcgtgcagc gggtcgcccc ggtccgtgct gaaggcgatc
    22561 atccagagga tcgggagccc cctgagggca accacgaggt cgcgcagtgc cgtcagggcg
    22621 ggccggctcg ccaggtgcag atcgtcgaga acgacggcgg tgcggatgcc gtcggcatgg
    22681 cgaagccgtg tccgcgccgc ctcgatcgcg gcgtcggagc cggccggggt accgtccacg
    22741 accgcgaagc cgtcggcgtc ggcgagcttg gcggcttccg ccaggaagcg ggtcttcccc
    22801 gcaccgggtg ccgcctccac caggaggacc gcgctgcgcc cgccgcgcgc cacccggcgc
    22861 aactgtgcgc cggtccgggc cagttgcttt tcccggccgc gcacctctgc tggggaaatg
    22921 gggtgcctcg ggtgaaccgg ggcggaatct atcttgcttc tctccattac cgaccgcgaa
    22981 gaggcgtgca tcttctccct catcgacaac tttgatcaag ccatttcata tccgatcaca
    23041 agaccgctcg gggggcaaga ccacccatag cgtccctttg ccgcaccgtc gccgtcggta
    23101 aatcgcccgg aaaccgaccg gaaaaccagt cggcgaaaat gagcagggcg tcgtcaggta
    23161 ccggccacga gccatgctgc aggacgacca ccccatgaac gcaagggatt cggcccccgg
    23221 gcgcgccgtc tgggatctga tcgccacggc ggcctccctg cgcggaaaag cgcccactct
    23281 ccgccggacc agcaccgaag gcagaccgtg gcgat
//
