LOCUS       NZ_CP029254            20658 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Streptomyces spongiicola strain HNM0071 chromosome, complete genome.
ACCESSION   NZ_CP029254
VERSION     NZ_CP029254.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces spongiicola
  ORGANISM  Streptomyces spongiicola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7180417)
  AUTHORS   Zhou,S. and Huang,X.
  TITLE     Complete genome sequence of the Type Strain of Streptomyces
            spongiicola HNM0071, the producer of staurosporine
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7180417)
  AUTHORS   Zhou,S. and Huang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-MAY-2018) Institute of Tropical Agriculture and
            Forestry, Hainan University, No 58, Haikou, Hainan 570228, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: ABySS v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 850.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003122365.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 01:04:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,008
            CDSs (total)                      :: 5,921
            Genes (coding)                    :: 5,739
            CDSs (with protein)               :: 5,739
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 182
            CDSs (without protein)            :: 182
            Pseudo Genes (ambiguous residues) :: 0 of 182
            Pseudo Genes (frameshifted)       :: 47 of 182
            Pseudo Genes (incomplete)         :: 161 of 182
            Pseudo Genes (internal stop)      :: 9 of 182
            Pseudo Genes (multiple problems)  :: 32 of 182
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:10:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6760718
            Orig. end                         :: >6781376
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029254.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..>20658
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="melanin"
                     /product="terpene"
                     /region_number="26"
                     /rules="melC"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..>20658
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="neighbouring"
                     /product="melanin"
                     /product="terpene"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..10411
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10411
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5411](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5411
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    complement(44..62)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.43"
                     /tool="antismash"
     gene            115..819
                     /locus_tag="DDQ41_RS29400"
                     /old_locus_tag="DDQ41_29400"
     CDS             115..819
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267828.1"
                     /locus_tag="DDQ41_RS29400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29400"
                     /product="succinate dehydrogenase"
                     /protein_id="WP_167450291.1"
                     /transl_table=11
                     /translation="MALAPRTDRRPSMTRTLWGSTVGKKAVMAATGLIMLGYLLVHMLG
                     NLKIFFGSGEFNGYAHWLRTLGEPFLHHEWALWIVRVVLLAAVVLHGVSAYQLSRRDIR
                     ARPHGYAHKRRRASYATRTMRWGGVILGLFIVWHLLDLTTLTVNENAQPGRPYENVVAT
                     FSTPYGNAVYLTAMLALGLHVRHGFWSAAQTLGAGSARRDRALRAAADGLALVLTLGFV
                     SVPVAVMTGVVS"
     cand_cluster    383..>20658
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    383..>20658
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10382:>10658](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      10383..>10658
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
     gene            821..2767
                     /locus_tag="DDQ41_RS29405"
                     /old_locus_tag="DDQ41_29405"
     CDS             821..2767
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240686.1"
                     /locus_tag="DDQ41_RS29405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29405"
                     /product="fumarate reductase/succinate dehydrogenase
                     flavoprotein subunit"
                     /protein_id="WP_109297186.1"
                     /sec_met_domain="DAO (E-value: 4.7e-07, bitscore: 28.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHPHYETGAPIADTRAPEGPIADRWDRRRFAARLVNPANRRKHT
                     VIVVGTGLAGGSAGATLAEQGYRVVQFCYQDSPRRAHSIAAQGGINAAKNYRNDGDSVH
                     RLFYDTVKGGDFRARESNVHRLAQISVEIIDQCVAQGVPFAREYGGLLDTRSFGGVQVS
                     RTFYARGQTGQQLLLGAYQALSRQIAAGNVEMHPRTEMLDLIVVGGRARGIVARDLVTG
                     RIDAYTADAVVLATGGYGNVFYLSTNAMNSNATAVWRAHRRGAYFANPCFTQIHPTCIP
                     RTGDHQSKLTLMSESLRNDGRIWVPKAKGDPRPAGEIPEDERDYYLERLYPSFGNLVPR
                     DIASRAAKNVCDEGRGVGPGGQGVYLDFADAVRRLGRAGVEEKYGNLFDMYERITAENP
                     YEVPMRIYPAVHYTMGGLWVDYDLQTTVPGLFAIGEANFSDHGANRLGASALMQGLADG
                     YFVLPSTVNDYLARHPHARAVDAAHPEVTQVLAETGERLNRLLSADGDRTPDSFHREIG
                     ELMWEFCGMARTGAGLREALDRIPRIREEFWRRIKVPGSGDELNQSLEKANRVVDYLEL
                     AELMCLDALHRTESCGGHFREESQTPDGEARRRDEEFSYAAAWEFAGTGAPPVLHREDL
                     VFEYVHPTQRSYA"
     misc_feature    complement(827..844)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            2764..3510
                     /locus_tag="DDQ41_RS29410"
                     /old_locus_tag="DDQ41_29410"
     CDS             2764..3510
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523104.1"
                     /locus_tag="DDQ41_RS29410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29410"
                     /product="succinate dehydrogenase/fumarate reductase
                     iron-sulfur subunit"
                     /protein_id="WP_109297187.1"
                     /transl_table=11
                     /translation="MKLGLRVWRQKNADAPGAMVTYEVDGVSPDMSFLEMLDTLNEELV
                     LRGEEPVAFDHDCREGICGACSLVIDGDAHGPERTTACQLHMRSFDDGDTIDVEPWRAS
                     AFPVVKDLVVDRSALDRIIQAGGYVSVPTGSAPEPHATPVPKADADSAFEHAECIGCGA
                     CVAACPNGSAMLFTSAKVNHLNVLPQGAPERETRVLDMVAAMDEEGFGGCTLAGECATA
                     CPKGIPLPSITAMNREWLRAVRKAER"
     gene            complement(3693..4472)
                     /locus_tag="DDQ41_RS29415"
                     /old_locus_tag="DDQ41_29415"
     CDS             complement(3693..4472)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (9-248). E-value: 6.6e-42. Score:
                     135.4. Matches aSDomain:
                     nrpspksdomains_DDQ41_RS29415_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947259.1"
                     /locus_tag="DDQ41_RS29415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29415"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_109297188.1"
                     /transl_table=11
                     /translation="MGDTPAVRIERDGPVLTVVLSRPEVRNAVDGPTAALLADAFRRFE
                     ADEDASVAVLWGEGGTFCAGADLRAVGTERGNTVTADGDGPMGPTRMRLSKPVIAAVSG
                     HAVAGGLELALWCDLRVAERDAVFGVFCRRWGVPLIDGGTVRLPRLVGESRAMDLILTG
                     RPVQAAEAYEIGLANRLAAPGESRRAAEQLAREIAAFPQLCLRHDRLSAREQHGLPEPE
                     ALARELRHGLVPLTAGETSSGAARFTGGAGRHGSFTD"
     aSDomain        complement(3729..4445)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DDQ41_RS29415_ECH.1"
                     /evalue="6.60E-42"
                     /label="DDQ41_RS29415_ECH.1"
                     /locus_tag="DDQ41_RS29415"
                     /protein_end="248"
                     /protein_start="9"
                     /score="135.4"
                     /tool="antismash"
                     /translation="ERDGPVLTVVLSRPEVRNAVDGPTAALLADAFRRFEADEDASVAV
                     LWGEGGTFCAGADLRAVGTERGNTVTADGDGPMGPTRMRLSKPVIAAVSGHAVAGGLEL
                     ALWCDLRVAERDAVFGVFCRRWGVPLIDGGTVRLPRLVGESRAMDLILTGRPVQAAEAY
                     EIGLANRLAAPGESRRAAEQLAREIAAFPQLCLRHDRLSAREQHGLPEPEALARELRHG
                     LVPLTAGETSSGAARFT"
     misc_feature    complement(4703..4717)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.18"
                     /tool="antismash"
     misc_feature    4704..4718
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.07"
                     /tool="antismash"
     misc_feature    4762..4775
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.66"
                     /tool="antismash"
     gene            5001..5411
                     /locus_tag="DDQ41_RS29420"
                     /old_locus_tag="DDQ41_29420"
     CDS             5001..5411
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947258.1"
                     /locus_tag="DDQ41_RS29420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29420"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_109297189.1"
                     /sec_met_domain="melC (E-value: 2.5e-44, bitscore: 149.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGITRRRALGAAAGAAAGLAAAGAAHAAIRTTDPRPQHAPGGAT
                     AVPGSFDEVYQGRRIQGHPTHHGGHGGGRHGGHDAGYTVRVDGEELHVMRNADGTWISV
                     VNHYEPRATPRALARAAVTELQGAALVPLALG"
     gene            5429..6256
                     /locus_tag="DDQ41_RS29425"
                     /old_locus_tag="DDQ41_29425"
     CDS             5429..6256
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015038020.1"
                     /locus_tag="DDQ41_RS29425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29425"
                     /product="tyrosinase family protein"
                     /protein_id="WP_109297190.1"
                     /transl_table=11
                     /translation="MTVRKNQAQLTADEKRRFVNALLALKRNGRYDTFVTTHNAFIMSD
                     TDNGDRVGHRSPSFLPWHRRFLIQFEQALQSVDRSVALPYWDWTADRTTASSLWAADFL
                     GGTGRARDGQVMDGPFAASSGGWAVNVRVDGRTFLRRALGAGGRQLPTRADVESVLAMS
                     TYDAPPWNSASDGFRNHLEGWRGVNLHNRVHVWVGGQMATGVSPNDPVFWLHHAFIDKL
                     WADWQRRHPDSAYLPTAGTPNVVDLRESMRPWTDVTPADMLDHRPHYTYDTAA"
     gene            complement(6836..7573)
                     /locus_tag="DDQ41_RS29435"
                     /old_locus_tag="DDQ41_29435"
     CDS             complement(6836..7573)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891670.1"
                     /locus_tag="DDQ41_RS29435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29435"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_109297191.1"
                     /transl_table=11
                     /translation="MRFTVLGASGLIGSRTAERLAAAGHDVVPATRSTGVDVVSGEGLR
                     EAFSGSDVVVDVTNSPTSDASSVDFFESSANAVGAAAREAGVRHLVILSVVGVDRVPQL
                     DYYRAKTAQEAIVASGRTPYSIVRATQFFEFVEAIMSWTTDGGVVRLPRTPLQPIAASD
                     VAAAVAGTAAGAPLQGIRDIGGPEVFPLDELGRIALAARPDGRSVVTDDRAGPFALVAG
                     DVLVAPEGSDLGPTYYGDWLERR"
     misc_feature    8096..8108
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     gene            complement(8105..8329)
                     /locus_tag="DDQ41_RS29440"
                     /old_locus_tag="DDQ41_29440"
     CDS             complement(8105..8329)
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947254.1"
                     /locus_tag="DDQ41_RS29440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29440"
                     /product="dodecin"
                     /protein_id="WP_109297192.1"
                     /transl_table=11
                     /translation="MSHHTYRVTEIVGTSHEGVDQAIRNGVARAGQTLRGLDWFEVTQV
                     RGNIEDGEIEHFQVGLKVGFRIEDAEGAG"
     gene            8848..9618
                     /locus_tag="DDQ41_RS29445"
                     /old_locus_tag="DDQ41_29445"
     CDS             8848..9618
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891668.1"
                     /locus_tag="DDQ41_RS29445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29445"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_109297193.1"
                     /transl_table=11
                     /translation="MPASSAVAPLVAAEPRYVVSLARDQQDVRAAQRLRHQVFAGEMGA
                     RLEGPEPGLDADAFDAYCDHILVRREDTGGVVGTYRVLPPERARVAGRLYSETEFDLSR
                     LAPLRDDLVEVGRSCVHPAHRNGAVIALVWAGLARYMTRTGRTWLSGCCSVPLADGGGL
                     AAATWDAVRAKHLAPEDYRVTPHKPWSADGVAHPGGRTGLPPLLRGYLRLGAWVCGAPA
                     HDPDFGVADLYVLLSLRRTDPRYLRHFLSLAPVK"
     gene            9819..>10169
                     /locus_tag="DDQ41_RS33170"
                     /pseudo=""
     CDS             9819..>10169
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013702.5"
                     /locus_tag="DDQ41_RS33170"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="lysophospholipid acyltransferase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRAFGVRVRVSGAVPPRRLPGLPPGPGTLVVPNHVSWLDIPLVAS
                     VLPGRMLAKREVRRWPVLGPLARLGGTLFVDRDRLRELPAVVGAVAGALRRGSRVVVFP
                     EGSTWCGRERGRF"
     gene            10383..>10658
                     /locus_tag="DDQ41_RS31830"
                     /pseudo=""
     CDS             10383..>10658
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056177.1"
                     /locus_tag="DDQ41_RS31830"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="squalene/phytoene synthase family protein"
                     /pseudo=""
                     /sec_met_domain="phytoene_synt (E-value: 3.7e-29, bitscore:
                     100.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 6.5e-13,
                     bitscore: 47.0, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYGEQRTVHALYGFARWADDIVDDLDSDATPAERATALDRLSER
                     LDAGLRLGRSPEPVVHALAHTARRYRIDHRHFTDFLASMRSDLEVTD"
     gene            complement(10776..11738)
                     /gene="egtD"
                     /locus_tag="DDQ41_RS29455"
                     /old_locus_tag="DDQ41_29455"
     CDS             complement(10776..11738)
                     /EC_number="2.1.1.44"
                     /GO_function="GO:0030745 - dimethylhistidine
                     N-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0052699 - ergothioneine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="egtD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308351.1"
                     /locus_tag="DDQ41_RS29455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29455"
                     /product="L-histidine N(alpha)-methyltransferase"
                     /protein_id="WP_109297194.1"
                     /transl_table=11
                     /translation="MSPFQLTRTLPEDATSAALRADVRHGLTRSPKELPPKWFYDARGS
                     ELFEEITRLPEYYPTRAEREILAGRAGDIAAATGARTLVELGSGSSEKTRFLLDALPEL
                     HSYVPVDVSESALTGAGEALLADRPGLHVHALIADFTRVLALPDAPGPRLVAFLGGTVG
                     NLLPVERADFLRSVRALLSPGDALLLGTDLVKDERVLVAAYDDAAGVTADFNKNVLAVV
                     NRELEADFPLDGFDHVAVWNDREEWIEMRLRARERANVKIRGLDLVVPFEAGEEIRTEV
                     SAKFRQEGVRSELAAAGMRLTGWWTDAEGRFALSLSAVA"
     gene            complement(11735..12490)
                     /gene="egtC"
                     /locus_tag="DDQ41_RS29460"
                     /old_locus_tag="DDQ41_29460"
     CDS             complement(11735..12490)
                     /GO_process="GO:0052699 - ergothioneine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="egtC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947250.1"
                     /locus_tag="DDQ41_RS29460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29460"
                     /product="ergothioneine biosynthesis protein EgtC"
                     /protein_id="WP_109297195.1"
                     /transl_table=11
                     /translation="MCRHIAYVGRPSALGDLLVRPPHGLLRQSWAPRRQRHGTVNADGF
                     GVGWYAEGDPVPARYRRAGPVWADPSFADLTRVVRSEALLAAVRDATEAGADGEAAAAP
                     FAAGPWLFSHNGAVRGWPGSVAPLAAALPAAELLSLEARCDSALVWALVLHRLREGDEP
                     GQAVADTVLDAARAAPGSRLNLLLTDGVTIAATAWGDTLWYLAVPGRGTVVASEPYDDD
                     PRWCEVPDRALLTATRTDVLLTPLKEPPA"
     gene            complement(12490..13803)
                     /gene="egtB"
                     /locus_tag="DDQ41_RS29465"
                     /old_locus_tag="DDQ41_29465"
     CDS             complement(12490..13803)
                     /GO_process="GO:0052699 - ergothioneine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="egtB"
                     /gene_functions="other (smcogs) SMCOG1226: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891664.1"
                     /locus_tag="DDQ41_RS29465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29465"
                     /product="ergothioneine biosynthesis protein EgtB"
                     /protein_id="WP_109297196.1"
                     /transl_table=11
                     /translation="MTETPVAADEVLRKRALEALTAARARTTLLTECVEDGELTAQHSP
                     LMSPLVWDLAHIGNQEEQWLLRAVAGREAIRPEIDSVYDAFEHPRAERPALPLLSPTES
                     RTYASDIRGRVLDVLEAHPLHGSPLVDSAFAFGMIAQHEQQHDETMLITHQLRRGPAAL
                     DAPDPPGGGTAGLPAEVPVPAGPFTMGTSAEPWALDNERPAHHRHADAFFIDTTPVTNG
                     AFQAFVADGGYTDERWWAPEGWEQIRRHGIGAPLFWRCEGGRWLRRRFGTTEPVPEDEP
                     VLHVSWYEADAYARWAGRRLPTEAEWEKAARHDPASGRSRRYPWGDEDPTPERANLGQR
                     HLRPAPAGAYPEGASPCGARQLIGDVWEWTSSDFLPYPGFAAFPYREYSEVFFGPGHKV
                     LRGGSFAVDPVACRGTFRNWDLPVRRQIFSGFRTARDA"
     gene            complement(13800..15068)
                     /gene="egtA"
                     /locus_tag="DDQ41_RS29470"
                     /old_locus_tag="DDQ41_29470"
     CDS             complement(13800..15068)
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0052699 - ergothioneine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="egtA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891663.1"
                     /locus_tag="DDQ41_RS29470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29470"
                     /product="ergothioneine biosynthesis glutamate--cysteine
                     ligase EgtA"
                     /protein_id="WP_109297197.1"
                     /transl_table=11
                     /translation="MAAAGRAGGAPPLSEDDAEELLRCICFKTGPPRTVGVELEWLVHD
                     RHLPHLPVDEDRLGRAFAGLRDLALGSALTFEPGGQLELSSPPAASLMECIDSTAADLA
                     AVRTALGRSGLVLTGCGHDPWNPPRRLLREPRYDAMEACLDRTGPAGRSMMCSTASVQV
                     CLDAGHEEPGPLGLGRRWQLGHLLGAVLVAAFANSPAGAGGRTGWRSTRQALWADLDPA
                     RALAPPSGATPRDAWAAHVLDTPVMCVRAAEGPWPVPEGLAFREWIRSGKPRPPTRADL
                     EYHLTTLFPPVRPRGHLELRMIDAQPGEAGWMVPLAVTAALFDDPQAAETAYRTVKPLA
                     ETAGPLPAPRNPLWVGAARHGLADPELHGAAVGCFAVALEALPRLGASKAVQDAVAAFH
                     ERHVLPGRCPADDFPLLGKETRS"
     gene            15228..16040
                     /locus_tag="DDQ41_RS33175"
                     /old_locus_tag="DDQ41_29475"
     CDS             15228..16040
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02452.1"
                     /locus_tag="DDQ41_RS33175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29475"
                     /product="TIGR02452 family protein"
                     /protein_id="WP_162602765.1"
                     /transl_table=11
                     /translation="MRARSRGVARQTREIVDAGRYRASDGHKVTIGGGPTAVVEGTWVY
                     GPGPSPCRWSPARTVSAYARSRGRAAWLPRGGRPGGTTTRRVSRASPRTAIPAGVPSLT
                     SDRDSGGGCLNGAHAQEEALCRASALHTAPPAVPGFDAHHREVSAPFCSDRVIRPLRVP
                     VPGRARRTPGHAVHGRAPRLSRARPPADRAVGDRRAALRGSGGLRGSGGLRGPAGGEGR
                     REGRAGRGHRRGPPPAHGRRSSGRPSLGRRVRAAGPGGGSGPPAGGHA"
     gene            16068..16337
                     /locus_tag="DDQ41_RS29480"
                     /old_locus_tag="DDQ41_29480"
     CDS             16068..16337
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947246.1"
                     /locus_tag="DDQ41_RS29480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29480"
                     /product="hypothetical protein"
                     /protein_id="WP_109297199.1"
                     /transl_table=11
                     /translation="MSTLPRRFEILLVPEHVEDRGGAAVEDSAVRTAVVETTGERGASG
                     YPRYAGHGVVADIDPETRTVEALLVDGSELDYGLTALVRDWQPG"
     gene            complement(16626..17006)
                     /gene="trxA"
                     /locus_tag="DDQ41_RS29485"
                     /old_locus_tag="DDQ41_29485"
     CDS             complement(16626..17006)
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="trxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129204.1"
                     /locus_tag="DDQ41_RS29485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29485"
                     /product="thioredoxin"
                     /protein_id="WP_109297200.1"
                     /transl_table=11
                     /translation="MSTVELTKENFDQVVSGNDFVLIDFWASWCGPCRQFAPVYEGASE
                     RHQDLVFAKVDTEAQPELAAAFDIRSIPTLMIVRENVAVFSQPGALPEPVLEDVIGQAR
                     GLDMDEVRKSIEEAQQNEAPQG"
     gene            17176..18699
                     /locus_tag="DDQ41_RS29490"
                     /old_locus_tag="DDQ41_29490"
     CDS             17176..18699
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947244.1"
                     /locus_tag="DDQ41_RS29490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29490"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_262508612.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 6e-45, bitscore:
                     152.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAVEYDVVVLGAGPTGENVADRTRAAGLSTAVVEGELVGGECS
                     YWACMPSKALLRPVIAGSDARRVPGVRQALRGPLGTEDVLAHRDEMTSHWRDDGQVSWL
                     DGIGARLYRGQGRLHGPRRVVVEGPEGERHVLTARHAVAVCTGSRAALPDLPGLAGARA
                     WTSREATSAQAVPRRLVVVGGGVVGTEMATAWQGLGSRVTLLVRGRGLLPRMEPFVGEH
                     IAESMAAAGVTVRTGAGAAAVNRPDPGGPVTVVLDGGELIEADEVLFATGRAPRTDDIG
                     LDTVGLKPGSWLSVDDSCRVDGHDWLYGVGDVNRRALLTHQGKYQARIAGAAIVARARR
                     CPLLETDRWGAHAATADHDAVPQVVFTDPEAAAVGLSLAQARAAGHRVRAVDKDLAAVA
                     GASLFVDDYRGRARMVVDLDRQILLGATFVGPGVSELLHSATIAVAGEVPIDRLWHAVP
                     SYPTISEVWLRLLEEYRDGSDATQGSDATHGSDGSDATHGSDGSDRQDG"
     gene            complement(<18757..19155)
                     /locus_tag="DDQ41_RS29495"
                     /old_locus_tag="DDQ41_29495"
                     /pseudo=""
     CDS             complement(<18757..19155)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554226.1"
                     /locus_tag="DDQ41_RS29495"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="DDQ41_29495"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNGGHHGFGTPAERWDRVWFLFDAEEYAAAARILDGPVAEEPGRV
                     APRLLPAHAHHHPARPGRAGTGLPRRAGTRSGC"
     gene            19299..20252
                     /locus_tag="DDQ41_RS29500"
                     /old_locus_tag="DDQ41_29500"
     CDS             19299..20252
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1208: pirin
                     domain-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059009.1"
                     /locus_tag="DDQ41_RS29500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_29500"
                     /product="pirin family protein"
                     /protein_id="WP_109297202.1"
                     /transl_table=11
                     /translation="MSNLDRQAALSVCGGRGFVVADPVRELLNPRRVRLGESTEVRRLL
                     PNLGRRMVGAWCFVDHYGPDDIAGEPGMQVPPHPHMGLQTVSWLHQGEVLHRDSTGSLR
                     TIRPGELGLMTSGRAISHSEESPKSRARFLHGAQLWVALPDAHRHAEPHFQHHAELPRV
                     TASGLTATVILGEFAGARSPGSVYTPIVGADLALTRGTGTAVPLEPDFEYAVLSMSGET
                     RVDGVPVLPGSMLYLGCGRGELPLRAESDAALMLLGGEPFEEELIMWWNFIGRSHEEIA
                     QAREDWMSSARFGRVEGYDGGRLPAPELPPVTLKPR"
ORIGIN
        1 cacgaagtac cggagctgct ggaactgcat cctgccagga tagcctgagt ctatcgacag
       61 cagccagacc atgtcttgga cctctggtca cccctccgcc tagcgtctgt gtccatggca
      121 ctggcaccac ggacggaccg acggccgtcc atgacgcgca cgctctgggg atcgaccgtc
      181 ggcaagaagg ccgtgatggc cgcgaccggt ctgatcatgc tcggctacct cctcgtccac
      241 atgctgggca acctcaagat cttcttcggt tccggcgagt tcaacggcta cgcccactgg
      301 ctgcgcaccc tgggcgagcc gttcctccac cacgagtggg cgctctggat cgtccgcgtc
      361 gtcctcctcg ccgccgtcgt actgcacgga gtgtcggcct accagctcag ccggcgggac
      421 atccgggccc gcccacacgg gtacgcccac aagcgccggc gcgcgagcta cgccacccgc
      481 accatgcgct ggggcggtgt catcctcggg ctgttcatcg tctggcacct gctggacctg
      541 accacgctca ccgtcaacga gaacgcccag ccgggcaggc cgtacgagaa cgtcgtcgcg
      601 accttctcca ccccctacgg caacgccgtc tacctcaccg cgatgctcgc cctcggcctg
      661 cacgtccgcc acgggttctg gagcgccgcc cagaccctcg gcgcgggcag cgcgcgccgc
      721 gaccgagcgc tcagggccgc cgccgacggc ctcgcgctgg tgctgacgct gggcttcgtc
      781 tcggtacccg tcgccgtcat gaccggagtc gtgagctgac atgagccatc cgcactacga
      841 gaccggcgcc ccgatcgccg acaccagggc gcccgagggc cccatcgccg accgctggga
      901 ccgccgccgc ttcgccgcca ggctggtcaa cccggccaac cgccgcaagc acaccgtcat
      961 cgtggtcggc acgggcctgg ccggcggctc ggccggcgcg accctcgccg aacagggcta
     1021 ccgcgtcgtg cagttctgct accaggactc cccgcgccgc gcccactcca tcgccgccca
     1081 gggcggcatc aacgcggcca agaactaccg caacgacggc gactccgtgc accgcctctt
     1141 ctacgacacc gtcaagggag gcgacttccg ggcgcgggag tccaacgtgc accggctcgc
     1201 gcagatctcc gtcgagatca tcgaccagtg cgtcgcccag ggcgtgccct tcgcccggga
     1261 gtacggcggc ctcctcgaca cccgctcctt cggcggcgtc caggtctccc gtacgttcta
     1321 cgcccgcggc cagacggggc agcaactgct gctcggcgcc taccaggcgc tgtcccggca
     1381 gatcgccgcc ggcaacgtgg agatgcaccc gcgcaccgag atgctggacc tgatcgtcgt
     1441 cggcgggcgg gcccgcggca tcgtggcccg cgacctggtc acgggccgga tcgacgcgta
     1501 caccgccgac gccgtcgtcc tggccaccgg cggctacggc aacgtcttct acctctcgac
     1561 gaacgcgatg aactccaacg ccaccgccgt gtggcgggcc caccggcgcg gcgcgtactt
     1621 cgccaacccc tgcttcaccc agatccaccc cacctgcatc ccgcgcaccg gcgaccacca
     1681 gtccaagctg acgctgatga gcgagtcgct gcgcaacgac ggccggatct gggtaccgaa
     1741 ggcgaagggc gacccccgcc ccgcgggcga gatacccgag gacgagcgcg actactacct
     1801 cgagcgcctc tacccgtcgt tcggcaacct cgtgccgcgg gacatcgcct cgcgcgcggc
     1861 gaagaacgtc tgcgacgagg gccgcggtgt cggccccggc ggccagggcg tgtacctcga
     1921 cttcgccgac gccgtccgcc ggctcggccg ggccggggtc gaggagaagt acggcaacct
     1981 cttcgacatg tacgagcgga tcaccgcgga gaacccctac gaggtcccga tgcggatcta
     2041 tcccgccgtg cactacacca tggggggact gtgggtcgac tacgacctcc agaccaccgt
     2101 gcccggcctg ttcgcgatcg gcgaggccaa cttctccgac cacggcgcca accggctcgg
     2161 cgcctccgcg ctcatgcagg gcctcgccga cggctacttc gtcctgccgt cgaccgtcaa
     2221 cgactacctc gcccgccatc cgcacgcacg agccgtcgac gcggcccacc ccgaggtcac
     2281 gcaggtgctc gccgagaccg gggaacggct gaaccggctg ctgtccgccg acggcgaccg
     2341 tacgcccgac tcgttccacc gcgagatcgg tgagctgatg tgggagttct gcggcatggc
     2401 ccgcaccggc gccgggctgc gcgaggccct cgaccggatc ccccggatac gcgaggagtt
     2461 ctggcgccgg atcaaggtgc cgggcagcgg cgacgaactc aaccagtcgc tggagaaggc
     2521 gaaccgcgtc gtcgactacc tggaactggc cgagctgatg tgcctcgacg cactgcaccg
     2581 cacggagtcc tgcggcggcc acttccgcga ggagtcccag accccggacg gcgaggcccg
     2641 gcgcagggac gaggagttct cctacgccgc cgcctgggag ttcgccggca ccggcgcccc
     2701 gcccgtcctg caccgggaag acctcgtctt cgagtacgtc caccccaccc aacggagcta
     2761 cgcatgaagc tcggactgcg cgtctggcgc cagaagaacg ccgacgcacc cggcgccatg
     2821 gtgacctacg aggtcgacgg cgtctctccg gacatgtcgt tcctggagat gctcgacacg
     2881 ctcaacgagg aactcgtcct gcgtggggag gagccggtcg ccttcgacca cgactgccgg
     2941 gagggcatct gcggggcctg ctcgctggtc atcgacggag acgcgcacgg cccggagcgc
     3001 accaccgcct gccagctcca tatgcgctcg ttcgacgacg gcgacacgat cgacgtcgag
     3061 ccttggcgtg cctcggcctt ccccgtggtg aaggacctgg tggtggaccg ctcggcgttg
     3121 gaccggatca tccaggcggg cggctacgtc tccgtcccca ccgggtccgc cccggagccc
     3181 catgccacgc cggtccccaa ggccgacgcc gactccgcct tcgagcacgc cgagtgcatc
     3241 ggctgcggag cgtgcgtcgc cgcctgcccc aacggctcgg ccatgctctt cacctcggcg
     3301 aaggtcaacc acctcaacgt gctcccgcag ggcgcgcccg agcgcgagac ccgggtcctc
     3361 gacatggtcg cggccatgga cgaggagggc ttcggcggct gcaccctcgc cggcgagtgc
     3421 gcgacggcct gcccgaaggg catcccgctc ccgtcgatca ccgcgatgaa ccgcgaatgg
     3481 ctgcgtgccg tgcggaaggc cgagcggtag cggtcccggc ccaccgcggc ggcgcgggcg
     3541 gcgggtgtcc gcacgcaccc ccgggacgcc gcgggccggg tggtccgtcg ggtcgggtgg
     3601 tccgtcgggt cgggtggtcc gtccggccga cgcacccccg gggcgccgcg ggccgggtgg
     3661 tccgtccggc cgggttcggg cccggccgga cgtcagtccg tgaaggaccc gtggcggccc
     3721 gcaccgccgg tgaagcgcgc cgcgcccgac gaggtctcgc ctgcggtcag cggcaccagt
     3781 ccgtgacgga gttcgcgggc cagagcctcg ggttcgggca gcccgtgctg ttcgcgtgcg
     3841 gagagccggt cgtggcgcag gcacagctgg gggaacgcgg cgatctcccg ggcgagttgc
     3901 tcggccgccc ggcgggactc cccgggcgcg gccagccggt tggccaggcc gatctcgtac
     3961 gcctcggcag cctgcaccgg gcggccggtg aggatcaggt ccatggcgcg gctctctccg
     4021 acgagccgcg ggaggcgtac cgttccaccg tcgatcagcg ggacgcccca gcggcggcag
     4081 aagaccccga agaccgcgtc ccgctcggcg acccgcagat cgcaccagag agcgagctcc
     4141 aggccgccgg ccacggcgtg gcccgagacc gcggcgatca cgggcttgct cagccgcatc
     4201 cgggtcgggc ccatcgggcc gtcgccgtca gcggtgaccg tgttgccgcg ctcggtgccc
     4261 acggccctga ggtcggcccc ggcgcagaac gtgccgccct cgccccagag cacggcgacc
     4321 gaggcgtcct cgtccgcctc gaaccgccgg aacgcgtcgg ccagcagcgc cgccgtgggg
     4381 ccgtccaccg cgttgcgcac ctcggggcgg ctgaggacga cggtgaggac cgggccgtcg
     4441 cgttcgatcc gtacggccgg tgtgtcgccc atcgcccgtc ctcctcgccg atgtgccgca
     4501 ggctggtgcc tgggtgcctg ggtgcctggg tgcctgggtg cctgggtgcc cggtggccgg
     4561 tggccggtgc cttcgcctgc cgcctgggtt cggctggtgt ccgggcccgt tcggggatcc
     4621 ttccgcggcg ccggtcgcgg cacaaccccg cggaccggcc gacggtccgt gcatgggggc
     4681 attcacgctt ctgctcccgg catattttcc ggacagattc ccgctgtgac gtccggcacc
     4741 ccagacggcc tcctggtgaa gattcttcac cacatcgcca tatccggctg cggttcttgc
     4801 gtccgcgcga tgcgcgagtg cccaaaacag caagatcgat ttgcttcgag tccgcaccgt
     4861 acgtggtgac ttgtccgtat ggcggccaac ctgcccgcct cgactactcc ccggctgcgg
     4921 acggcctgta ggcatgggaa cggcggttcc ggcccgacca ccgcaaccgc cgctccatcg
     4981 aatccacttg ggggtaacgc atgtccggaa tcacccgccg ccgggcgctc ggcgccgcag
     5041 cgggcgccgc cgccggcctc gccgcggcag gcgcggctca cgcggcgata cggaccaccg
     5101 atccgcggcc gcagcacgca cccggcggcg cgaccgcggt gccgggctcg ttcgacgagg
     5161 tctaccaggg ccgccgcata cagggccacc ccacgcacca cggcggtcac gggggcggcc
     5221 ggcacggcgg tcacgacgcc ggctacaccg tccgcgtgga cggggaggaa ctccacgtga
     5281 tgcgcaacgc cgacggcacc tggatcagtg tcgtcaacca ctacgagccg agggccaccc
     5341 cgcgggccct cgcccgcgcg gcagtcaccg aactccaggg tgccgccctc gtcccgctcg
     5401 ccctcggctg aaccggagca ccaccgcgat gaccgtacgg aagaaccagg cccagctcac
     5461 cgccgacgag aagcggcggt tcgtcaacgc cctgctcgca ctcaagcgca acgggcggta
     5521 cgacaccttc gtcaccacgc acaacgcctt catcatgagc gacaccgaca acggagaccg
     5581 cgtaggccac cgctcgccct cgttcctgcc gtggcaccgg cgattcctca tccagttcga
     5641 gcaggcactg cagtcggtgg accggtcggt ggcgctgccg tactgggact ggacggccga
     5701 ccgcaccacc gcctcctcgc tgtgggccgc cgacttcctc ggcggcaccg gccgcgcacg
     5761 cgacggacag gtcatggacg gccccttcgc cgcctcgtcc ggcggctggg ccgtcaacgt
     5821 ccgcgtcgac ggccgcacct tcctccgccg cgcgctgggc gccgggggcc ggcagctgcc
     5881 gacgcgggcc gatgtcgagt ccgtactggc catgtccacc tacgacgctc caccgtggaa
     5941 cagcgcctcg gacggcttcc gcaaccacct cgagggctgg cgcggcgtca atctgcacaa
     6001 ccgcgtccat gtctgggtcg gcggccagat ggcgaccggc gtctccccga acgacccggt
     6061 gttctggctc caccacgcct tcatcgacaa gctctgggcg gactggcagc ggcgccaccc
     6121 ggactcggcc tatctgccga ccgcgggcac gccgaacgtc gtcgatctcc gggagagcat
     6181 gcgcccgtgg acggacgtga caccggcgga catgctcgac caccggccgc actacaccta
     6241 cgacacggca gcctgacccg ggcagcctgt cccgggcagc ctgtcccggg ccgcctgttc
     6301 tgggccggag cgacaccccg taccgggcac gccggccggt gaccgtccgc gtcaccggcc
     6361 ggcgcggctt ccgcccccgg tcgtacggcg gtaccgttcc gccgcccgtc accccggccg
     6421 ggatccgccg cccccgccgc cgaacgatcc gggccggccg ccctgcgggt acggagggcc
     6481 ccttgaaccc ggggggtgcc gagggcctcc cggcaacggg accgcgaacc ggcgtccggt
     6541 ggtcggcgtc cggcctccgg tcgtcggcgt ctcgtgaccg gcgtctggtg accggcgtcc
     6601 ggcgtccggc gtccggcgtc cggcgtctgg cgtccggcgt ccggcgtctg gtgaccggtg
     6661 gtcggtgacc ggcgggcacg acctggcgag ccggtacccg ccgtgcggcg gatacccgca
     6721 ggcaccggtc cgccccgacc ggagtccggc gcgaacggac cccggaactc ggcgcggtgc
     6781 cggaagtggg gttccgcatg cggaacccgg cgcgaacggg ccccggagac cgggcctatc
     6841 ggcgctccag ccagtccccg tagtacgtcg gccccaggtc cgaaccctcc ggagcgacca
     6901 gaacgtctcc cgccaccagg gcgaacggcc ccgcccggtc gtcggtgacc acactgcggc
     6961 cgtcgggccg cgcggccagg gcgatccggc ccagctcgtc cagcgggaac acctcggggc
     7021 cgccgatgtc gcggatcccc tgcaacgggg cgcctgccgc ggtgcccgcg accgccgcgg
     7081 ccacgtcgga cgcggcgatc ggctggaggg gggtgcgcgg cagccggacg acgccgccgt
     7141 cggtcgtcca ggacatgatc gcttcgacga actcgaagaa ctgcgtcgcc cgcacgatcg
     7201 agtacggtgt ccgcccgctc gcgacgatcg cctcctgcgc ggtcttggcc cggtagtagt
     7261 cgagctgggg cacccggtcc acgccgacga ccgagagaat caccagatgg cgaacgccgg
     7321 cctcccgggc cgcggccccg acggcgttcg ccgaagactc gaagaagtcg acggaggaag
     7381 cgtcggacgt cggggagttc gtcacgtcga ccaccacgtc ggagccggag aaggcctccc
     7441 gaagaccctc accgctgacc acgtcgaccc cggtggagcg ggtggccggg acgacgtcgt
     7501 gcccggccgc cgccagccgt tcggctgtcc gcgagccgat caggccgctc gcccccagga
     7561 ccgtgaacct catggcgtac ctttcgtctc gtcggccgtt cgcgttcccg aggcgtcatg
     7621 acgccggcgg cgcgaaccgg agtgcctgtc gtgagccgat cggcccgagg cgggtcgagt
     7681 gggcatcgag cgctcggggt tcgggtgttc ggggttccgg gcttcggggt tccgggcttc
     7741 gggtctcggg tgttcgtgcg cccccgggcg gaacctcgcc cggcacggcg gccgccgcac
     7801 cgtaccgcgg cgtaccgcgc ggccggattc ccggcggctc ccgtccggag ccccgcctcg
     7861 ggccacagca cgccccgcgg cgcggcgggg cggtaccggc agagggaggg cagcgccccg
     7921 gccgaccggg tccggagccg ccgggttccg tggccgggcg ggctcacgag cggtcgatgg
     7981 ccgtcgcccc tgcgtgtccg caccccggtg ccgtgcggca ccggcatccg catccgcatc
     8041 ggcatcggtg ccggcgccgg caccgtggat gctcggggct cctgccgccg gtcgggtgac
     8101 ggtgtcagcc cgcgccttcc gcgtcctcga tgcggaaccc gaccttcagg ccgacctgga
     8161 agtgctcgat ctcgccgtcc tcgatgttgc cgcgcacctg cgtgacctcg aaccagtcga
     8221 gaccgcgcag cgtctgcccg gcccgtgcga cgccgttccg gatggcctgg tcgacgccct
     8281 cgtgcgaggt gccgacgatc tcggtgaccc ggtaggtgtg gtgggacatg agggccgctc
     8341 tcctctcagc cgtttcgttg gctccagtcc accgtgcccc agccccttcc gctccgcgag
     8401 gcgtcggggc caagtcccgt ccaccccgtc caccccgtcc aggccgttcg cccagtcgcc
     8461 cgttcgccca gcctgcgtca cctgggtcac ctgggtcacc tgggtcgtcc gggtcgtccg
     8521 ggccccatgg cggggcccgg tcggggaccc cgcggtggaa cacgggtccc gggcgcgggc
     8581 gcccggccct ggagcccggg gccgccgatc acccgagccg gtcccgaagc cggcccccgc
     8641 ccggccggtc ccgaatccgg cacgggcccc gagcacccgc ccgaccgcac cccggcagga
     8701 ggtcgcagga ggccgccggc cattcaggcg gcgcacatcc gcgctacgca ccgtcgtcac
     8761 gtcgagtcca gccggacgcg gaatgactgg ggagccggat cgccgcacgg tgcggcccgg
     8821 ctccaccgcc cggcagagga gaccgccatg cccgcatcgt ccgccgtcgc ccccctcgtc
     8881 gccgccgagc cccgctacgt ggtgtcgctc gcccgcgacc agcaggacgt acgggccgca
     8941 cagcggctgc gccaccaggt gttcgccggg gagatggggg cccgcctcga aggccccgaa
     9001 ccggggctgg acgccgacgc cttcgacgcg tactgcgacc acatcctggt gcgccgcgag
     9061 gacaccggcg gggtcgtcgg cacctaccgg gtgctgccgc cggagcgagc ccgggtcgcc
     9121 gggcggctct actccgagac cgagttcgac ctgtcccggc tggcccccct ccgcgacgac
     9181 ctcgtcgagg tgggccgctc ctgcgtccac cccgcccacc gcaacggcgc cgtcatcgcg
     9241 ctcgtctggg ccgggctcgc ccgctacatg acccgcaccg gccgcacctg gctgtccggc
     9301 tgctgctcgg tgccgctcgc cgacggaggc gggctcgccg ccgcgacctg ggacgccgtc
     9361 agggccaagc acctcgctcc ggaggactac cgggtcaccc cgcacaagcc ctggagcgct
     9421 gacggcgtcg cccaccccgg gggccgtacc gggctccccc cgctgctgcg gggctacctc
     9481 cgtctcgggg cctgggtctg cggtgcgccc gcccacgacc ccgacttcgg cgtcgccgac
     9541 ctctacgtcc tgctgtcgct gcgccgcacc gacccccgct acctgcggca cttcctctcc
     9601 ctggcgcccg tgaaatgagc gtctggctgc ccacggcgcc ctgcacgccc gccggctgcg
     9661 cgtcccctcg gtggccgacc gtgcggcggg ccaccgcggt cctccgcctt gccgcgggta
     9721 ccgcggcggt cctcgcgggc ctcgtactcg ccccggtggc ggccgtcctc ggcccggcgg
     9781 gccggggacg gctggccgca ctgtggtgcc gtacggtgat gcgggccttc ggcgtacggg
     9841 tccgggtgag cggcgcggtc ccgccccggc gcctgcccgg gctgcctccc ggaccgggca
     9901 cgctcgtcgt ccccaaccac gtctcctggc tggacatccc gctcgtcgcc tcggtcctgc
     9961 ccgggcggat gctggccaag cgcgaggtgc ggcggtggcc cgtcctcgga cccctcgccc
    10021 gtctgggcgg cacgctgttc gtggaccgcg accggctgag ggagcttccc gcggtcgtcg
    10081 gcgccgtggc cggcgcgctc cggcgcggct cgcgggtggt ggtgttcccc gaggggtcca
    10141 cctggtgcgg ccgggagcgg ggccgcttcc ggcccgccgc gttccaggcg gcgctggacg
    10201 ccggcgcggc cgtgcagccc gtgcacatcg cctaccggcc cgtcggcgcg gccgcgttcg
    10261 tcggcgacga cgcgctgggc gcctcgctgt ggcgggtcgc gacggccgcg gggctgaccg
    10321 cggagatcac cgtcctgccg ccgatccccg cggcggccca ccccgaccac ctcgcccgca
    10381 acctgcccta cggtgagcag cgcaccgtcc acgcgctgta cggcttcgcc cgctgggccg
    10441 acgacatcgt cgacgacctc gacagcgacg ccacccccgc ggaacgcgcg acggcgctgg
    10501 accggctgtc ggagcgcctc gacgccgggc tgcgcctcgg ccgcagcccc gaacccgtcg
    10561 tccacgccct cgcgcacacg gcccgccgct accgcatcga ccaccgccac ttcaccgact
    10621 tcctggcgtc catgcgcagc gacctggagg tgacggaccg cggggcgggg tgctcggggc
    10681 ggttcgccac gagccgggcc cgtcccgcca ggcgggtacg ggtgaagcgg tgccgccccg
    10741 cacccgcggc cccgggagcc gcgcccggtc cccgctcagg ccaccgccga cagggacagc
    10801 gcgaacctgc cctccgcgtc ggtccaccat ccggtgagcc tcatccccgc ggcggccagt
    10861 tccgaacgca ccccttcctg acggaacttc gcggagacct ccgtacggat ctcctcaccc
    10921 gcctcgaagg gaacgacgag atcgagtccg cggatcttca cattcgcccg ctcgcgtgcg
    10981 cgcaggcgca tctcgatcca ctcctcccgg tcgttccaga cggccacgtg gtcgaagccg
    11041 tcgaggggga agtccgcctc cagctcccgg ttgaccacgg cgaggacgtt cttgttgaag
    11101 tccgccgtga caccggcggc gtcgtcgtac gcggccacca gcacccgctc gtccttcacc
    11161 aggtccgtgc cgagcagcag cgcgtcgccg ggcgacagga gggcccgcac ggaccgcagg
    11221 aagtccgcgc gctcgacggg cagcagattg ccgaccgttc cgccgaggaa ggcgaccagc
    11281 cgcgggccgg gggcgtccgg cagggccagc acacgggtga agtccgcgat cagcgcgtgc
    11341 acatggaggc cgggccggtc cgccagcagc gcctcgccgg ccccggtcag cgcgctctcg
    11401 ctcacgtcca ccgggacata gctgtgcagc tccggcaggg cgtccagcag gaagcgggtc
    11461 ttctccgagg agccggagcc gagctccacc agggtgcggg cgccggtcgc cgcggcgatg
    11521 tccccggccc ggccggcgag gatctcccgc tcggcgcgcg tcgggtagta ctcgggcagc
    11581 cgggtgatct cctcgaacag ctcgctcccg cgggcgtcgt agaaccactt cggcggcagc
    11641 tccttgggac tgcgggtcag gccgtgccgc acgtcggcgc gcagcgcggc actcgtggcg
    11701 tcctcgggca gggtgcgggt cagctggaac gggctcacgc gggcggctcc ttgagcgggg
    11761 tcagcagtac gtcggtacgg gtcgccgtga gcagcgctcg gtccggcacc tcgcaccatc
    11821 gggggtcgtc gtcgtacggc tccgacgcca cgaccgtgcc ccggccgggc acggccaggt
    11881 accagagcgt gtcgccccag gcggtcgcgg cgatcgtcac gccgtcggtc agcagcaggt
    11941 tgaggcggga gcccggcgcg gcgcgggccg cgtcgagcac ggtgtcggcg acggcctggc
    12001 caggctcgtc accctcccgc agccggtgca gcaccagcgc ccacaccagg gcggagtcgc
    12061 agcgggcctc cagcgacagc agttccgcgg cgggcagcgc ggcggcgagc ggagccacac
    12121 tgccgggcca gccgcgcacc gctccgttgt ggctgaacag ccaggggccg gcggcgaacg
    12181 gtgcggccgc ggcctcgccg tcggcgccgg cctccgtggc gtcccggacg gctgccagca
    12241 gcgcctcgct gcggaccacc cgggtcaggt cggcgaagga cgggtcggcc cagacgggcc
    12301 cggcacgccg gtagcgggcg ggcaccggat cgccttccgc gtaccatccc acgccgaaac
    12361 cgtccgcgtt caccgtgccg tgccgctgcc ggcgcggtgc ccacgactgc cgcagcagcc
    12421 cgtgcggcgg ccgcaccagc aggtccccca gggccgacgg ccttccgaca taggcgatat
    12481 gacggcacat caggcgtccc tggcggtacg gaaaccggag aagatctgcc ggcgcaccgg
    12541 aaggtcccag ttgcggaacg tgccccggca ggccaccggg tccaccgcga acgagccgcc
    12601 ccgcagcacc ttgtgcccgg ggccgaagaa cacctccgag tactcgcggt acgggaacgc
    12661 cgcgaacccc gggtacggca ggaagtcgct cgacgtccac tcccacacgt cgccgatcag
    12721 ctgccgcgcc ccgcacggcg aggcaccctc cgggtacgcc ccggcgggcg cgggacggag
    12781 gtgccgctgc cccaggttgg cccgctccgg cgtcgggtcc tcgtcgcccc acgggtagcg
    12841 ccgcgaacgg ccggacgcgg ggtcgtgccg ggcggccttc tcccactcgg cctcggtggg
    12901 cagccgccgc cccgcccagc gcgcgtatgc gtccgcctcg taccagctga cgtgcagcac
    12961 cggctcgtcc tcgggcaccg gctcggtcgt cccgaaccgg cggcgcagcc accgcccgcc
    13021 ctcgcaccgc cagaacagcg gcgcgccgat gccgtgccgg cggatctgct cccagccctc
    13081 gggcgcccac cagcgctcgt cggtgtagcc gccgtccgcg acgaacgcct ggaaggcgcc
    13141 gttggtgacg ggtgtggtgt cgatgaagaa cgcgtccgca tggcggtggt gcgcgggccg
    13201 ttcgttgtcc agtgcccacg gctcggcgga ggttcccatg gtgaacggcc cggccggcac
    13261 cggcacttcg gccggcagcc cggcggtgcc gccccccggc gggtcggggg cgtccagcgc
    13321 cgccgggccg cgccgcaact gatgggtgat gagcatggtc tcgtcgtgct gctgctcgtg
    13381 ctgcgcgatc atcccgaagg cgaaggcgga gtccacgagg gggctgccgt gcagcgggtg
    13441 cgcctccagg acgtccagca cccggccgcg gatgtcggag gcgtacgtcc gggactcggt
    13501 gggggacagc agcggcaggg ccgggcgctc ggcacgcggg tgctcgaacg cgtcgtacac
    13561 ggagtcgatc tcgggccgga tcgcctcccg tccggcgacg gcccgcagga gccactgctc
    13621 ctcctggttg ccgatgtgcg ccaggtccca cacgagcggg gacatcaggg gcgagtgctg
    13681 ggcggtgagt tcgccgtcct cgacgcactc cgtcagcagc gtggtacggg ccctggccgc
    13741 ggtcagcgcc tccagggcgc gcttcctgag cacctcgtcc gcggccaccg gggtctcggt
    13801 catgagcggg tctccttacc gaggagcggg aagtcgtcgg ccgggcaccg gccgggcagg
    13861 acatggcgct cgtggaacgc ggcgaccgcg tcctgcacgg ccttcgacgc gcccagccgg
    13921 gggagggcct ccagggcgac ggcgaagcag ccgacggcgg cgccgtgcag ttcggggtcg
    13981 gccagtccgt gccgggcggc gcccacccac agcgggttgc ggggcgcggg cagcgggccg
    14041 gcggtctcgg cgagcggctt gacggtgcgg taggcggtct ccgcggcctg cgggtcgtcg
    14101 aagagcgccg cggtgacggc gagcgggacc atccagcccg cctccccggg ctgtgcgtcg
    14161 atcatgcgca gttcgaggtg accgcgcggg cgcaccggtg ggaagagcgt ggtcaggtgg
    14221 tactcgaggt cggcgcgggt gggcggccgg ggcttcccgg accggatcca ctcccggaag
    14281 gccagccctt ccggcaccgg ccacggaccc tccgccgcac ggacgcacat caccggcgtg
    14341 tccagcacat gcgcggccca ggcgtcacgg ggcgtcgcgc ccgaaggcgg tgccagggcc
    14401 cgcgccgggt ccagatcggc ccacagcgcc tgccgggtcg agcgccagcc ggtcctcccg
    14461 cccgctccgg cgggtgagtt ggcgaaggcg gcgaccagca cggcccccag caggtgcccc
    14521 agctgccagc ggcggccgag gcccagcggg ccgggctcct cgtgtccggc gtccagacac
    14581 acctgcacgg aggccgtgga gcacatcatg gaccggccgg cggggccggt gcggtcgagg
    14641 cacgcctcca tggcgtcgta gcggggctcg cgcagcagcc ggcgcggcgg gttccagggg
    14701 tcgtggccgc aaccggtcag cacgagcccg gagcggccga gtgcggtccg gaccgcggcc
    14761 aggtcggccg cggtggagtc gatgcactcc atcagcgacg cggcgggcgg cgagctgagc
    14821 tccagctgcc cgcccggttc gaaggtgagc gccgaaccga gggccaggtc ccgcagtccg
    14881 gcgaatgccc ggccgaggcg gtcctcgtcg acgggcaggt gcggcagatg ccgatcgtgc
    14941 acgagccatt ccagctcaac cccgacggtg cggggcgggc ccgtcttgaa gcagatgcac
    15001 cggagcagtt cctcggcgtc gtcctcggag agcggtgggg caccgcccgc gcggcctgct
    15061 gctgccatga tcgaattcct cctgtcgaag gcgttccgtc cacctaatgc caccgccgtg
    15121 gttctcacaa gagtgccccc ggaccgggtc cgtccggctt tccggcgagg tgagcggggt
    15181 ggtggagggc ctgccgggcg cctccccgac cattgaggac tccgggcgtg agggcacggt
    15241 cgaggggggt cgcgcgtcag acccgggaga tcgtcgacgc gggtcgctac cgggcttcgg
    15301 acggccacaa ggtgacgatc ggcgggggtc cgaccgccgt ggtcgagggg acatgggtgt
    15361 acgggccggg cccgagcccg tgccggtggt ccccggcgcg gaccgtttca gcctatgcga
    15421 ggtcacgggg gagagcagcc tggctgccgc gcggcggacg acccggcggg acgacgaccc
    15481 ggcgggtgtc ccgagcctcg cctcggaccg cgattccggc gggtgtcccg agcctcacct
    15541 cggaccgcga ttccggcggc gggtgcctca acggcgccca cgcgcaggag gaggcgctct
    15601 gccgcgcctc cgcgctccac accgcaccac cggccgtccc cgggttcgac gcccaccacc
    15661 gggaggtcag tgcccccttc tgctccgatc gggtgatccg cccgctccgg gtgcctgttc
    15721 ccggacgcgc gcggcggact cctggacacg ccgttcacgg ccgggctcct cgactgtccc
    15781 gggcccggcc cccggcagac cgcgcggtag gcgaccgtcg cgcggcgctg cgcgggtccg
    15841 gcgggctgcg cgggtccggc gggctgcgcg gtccggcggg aggggagggc cggcgggagg
    15901 ggagggccgg tcgggggcac cggcgagggc ctccaccggc tcacgggcgc cggtccagcg
    15961 gacgtccgtc gctggggagg cgggtccggg cggcgggtcc gggcggcggg tccgggccac
    16021 cggcgggcgg acatgcgtga cgggccgggc ctgactagcg tcagggcatg agcacacttc
    16081 cgcggcgctt cgagatcctg ctcgtgccgg agcacgtcga ggaccgcggt ggcgcggcgg
    16141 tggaggacag cgccgtccgc acggccgtgg tcgagacgac cggggaacgg ggggcgtccg
    16201 gctacccgcg ctacgccggg cacggagtcg tcgccgacat cgaccccgag acccgcacgg
    16261 tggaggcgct gctcgtggac ggctcggaac tcgactacgg gctgacggcg ctggtcaggg
    16321 actggcagcc cggctgaagc aacgcaaccg aggcagcccg cctgaagcgg ctcggctcga
    16381 gcggcgcgct ggcccgcccg accgcccgac cgcccgaccg cccgaccgcc cgcccgaccg
    16441 accgcccgcc cgaccgaccg cccggccggg ccggcgcggc ggcgggtgcc ggaccggtgt
    16501 cacgggaacg gctggccggt cgccgcggcc ttcacggccg ccgcccgcgg caaccaccgc
    16561 cgtggagcgg cgcgggagaa cgcccttccg gtccgcgccg ctccacgcgg ccgggggccg
    16621 gcgggtcacc cctgcggggc ctcgttctgc tgcgcctcct cgatggactt gcgcacctcg
    16681 tccatgtcca acccgcgggc ctggccgatc acgtcctcca ggaccggctc gggcagcgcg
    16741 cccggctgtg agaacaccgc gacgttctcc cggacgatca tcagcgtcgg gatcgagcgg
    16801 atgtcgaacg ccgccgccag ctccggctgc gcctccgtgt cgaccttggc gaagacgagg
    16861 tcctgatggc gttccgaagc gccctcgtac accggggcga actggcgaca cggaccgcac
    16921 caggaagccc agaagtcgat caggacgaag tcgttcccgg agacgacctg atcgaagttt
    16981 tccttggtga gctcgacagt gctcattacc tgctacctct tcctgggtgt cctggctgtc
    17041 ctgggtgtcc ggtcggcccc gtccctccgg cgccctcgcg gcgcgcgggg acgcccccga
    17101 caacgtgcgc ggggtgcggc cgtattccgc ctgcccctgt ggccgccgtc cacacctggc
    17161 accacactgg tcggtatgac ggcagccgtg gagtacgacg ttgtggtgct gggagccggg
    17221 ccgaccggcg agaacgtggc ggaccgcaca cgggccgccg gtctgagcac ggccgtggtg
    17281 gagggcgaac tcgtcggcgg ggagtgctcg tactgggcgt gcatgccgag caaggcgctg
    17341 ctgcggcccg tgatcgcggg ctccgacgcg cgccgggtgc ccggtgtccg ccaggccttg
    17401 cggggcccac tcggtacgga ggacgtcctc gcacaccgcg acgagatgac ctcgcactgg
    17461 agggacgacg gccaggtctc gtggctcgac ggcatcggcg cccgcctgta ccgcggacag
    17521 ggccgactgc acggcccccg cagggttgtg gtcgaggggc cggagggcga gcgccatgtg
    17581 ctgacagccc ggcacgcggt cgccgtgtgc accggcagcc gggcggcgct gccggatctg
    17641 ccgggtctcg ccggggccag ggcctggacc agccgcgagg cgaccagcgc tcaggccgtg
    17701 ccgaggcggc tcgtcgtggt gggcggcgga gtcgtcggta cggagatggc gaccgcctgg
    17761 cagggtctcg gctcccgggt gaccctgctg gtgcgcggcc gagggctgct gccgcggatg
    17821 gaaccgttcg tcggcgagca catcgcggag tcgatggccg cggccggggt gaccgtgcgg
    17881 accggcgcgg gtgcggccgc ggtcaaccgg cccgaccccg gcggcccggt caccgtcgtc
    17941 ctcgacggcg gtgagctgat cgaggccgac gaggtgctgt tcgccacggg ccgcgccccg
    18001 cgcaccgacg acatcgggct ggacacggtg ggtctgaagc ccggctcctg gctctcggtc
    18061 gacgacagtt gccgggtgga cggccacgac tggctgtacg gggtcggtga cgtcaaccgc
    18121 cgtgcgctgc tcacccacca gggcaagtac caggcccgaa tcgccggtgc ggccatcgtg
    18181 gcccgtgccc ggcgctgccc gctgctggag accgatcgct ggggcgccca cgcggcgacg
    18241 gccgaccacg acgccgtgcc gcaggtggtg ttcaccgacc cggaggcggc ggcggtcgga
    18301 ctgtcactgg cgcaggcccg tgccgccggg caccgggtcc gcgcggtcga caaggacctc
    18361 gcggccgtcg cgggcgcgag cctgttcgtc gacgactacc gcggccgcgc ccggatggtc
    18421 gtcgatctcg accggcagat cctcctcggc gccaccttcg tgggcccggg cgtcagcgaa
    18481 ctgctccact ccgccacgat cgcggtggcc ggggaggtgc cgatcgaccg gctgtggcac
    18541 gcggtgccct cctacccgac gatcagcgag gtgtggctgc ggctgctgga ggagtaccgc
    18601 gacggcagcg acgcgacaca gggcagcgac gcgacgcacg gcagcgacgg cagcgacgcg
    18661 acgcacggca gtgacggcag cgaccgccag gacggctgac cggcggtcgg gacggctgac
    18721 gcggcggagg cggcaaccgc cggttcgccg cgccccgggg aactccccgg acaccgccgc
    18781 cgccagtcgc agatgcggag cggccgcctc gctgtgcctg ccctgccgct ccggcgtgcg
    18841 gccgagcatc aggcgggcgc agtgctcgac cggatcgcgt tccagcaccg gatcgcgctt
    18901 gagtactcgg atcgcgcttc agcacccgga ccgcgttccc gcacggcgcg gaagtccggt
    18961 cccggctctg ccgggccggg ccgggtggtg gtgggcgtgt gccggcagca gccgcggggc
    19021 gacccggccg ggctcctccg cgacaggacc gtcgaggatc cgcgcggccg ccgcgtactc
    19081 ctcggcgtcg aagaggaacc acacgcggtc ccaccgctcg gccggtgtcc cgaacccgtg
    19141 gtggccgccg ttcacccggt ctccctcggc gcgttcgcgg gtgatcggcc agggcgctgc
    19201 tccacggtcc cgcggcgcgc tcaacccaag acagcggttg agcattccac gttcttggtt
    19261 gcgctggatc cgcaccgcac gggactaggt tgggcgccat gagcaatctc gaccgtcagg
    19321 ctgcgctctc cgtgtgcggc ggcaggggat tcgtggtggc cgatccggtc cgcgaactcc
    19381 tcaacccccg tcgcgtccgg ctcggcgagt ccaccgaggt ccgccggctg ctccccaacc
    19441 tcggtcgccg gatggtcggt gcctggtgct tcgtcgacca ctacggtccc gacgacatcg
    19501 ccggcgagcc cgggatgcag gtcccgccgc atccccatat gggcctgcag accgtgagct
    19561 ggctgcacca gggggaggtg ctgcaccggg acagcaccgg cagcctccgg acgatccggc
    19621 cgggggaact cgggctgatg acctcgggga gggcgatcag ccactccgag gagagcccga
    19681 agagccgcgc ccgctttctg cacggcgccc agctgtgggt cgccctgccc gacgcccacc
    19741 gccatgcgga accccacttc cagcaccacg cggagctccc gcgtgtcacc gcctccggtc
    19801 tgaccgccac cgtcatcctc ggcgagttcg ccggcgcccg ctcgcccggc tcggtgtaca
    19861 cgccgatcgt cggcgcggac ctcgccctga cccgcggcac cggcaccgcc gtcccgctcg
    19921 aaccggactt cgagtacgcc gtgctctcca tgtccggcga gacgcgcgtc gacggcgttc
    19981 ccgtgcttcc cggctcgatg ctctacctcg gctgcggccg cggcgaactg cccctccgcg
    20041 cggagtcgga cgccgcactg atgctcctcg gcggcgagcc gttcgaggag gagctgatca
    20101 tgtggtggaa cttcatcgga cggtcccacg aggaaatcgc acaggccagg gaggactgga
    20161 tgagcagcgc ccggttcggc cgggtagagg gctacgacgg aggccgactg cccgctcccg
    20221 aactcccgcc ggtgacgctg aaaccgcggt agggggtgcg tcgccccgcg ccgacgtgag
    20281 gtggggaggc gccgtcccgt cttccgtgcg tggcgtcggc ggtccggggt ggacggccgg
    20341 acggccggac cgggacggga ggttctggcg cgttcgtgag gacgggcggt gatctgcgaa
    20401 gtgacggcgc ccccggcgga cacggccggg ggcgccgagg tcctcgcatg tgcgctcgga
    20461 gtcgatcgcg gcggtgccgg tgagggccgt cggccatccc gtacgacggc tcgcgccgac
    20521 cgggtgccgg cgccggacgc ccgtcgggcc cggcaccggc gtgggtcctc gggtcaggcg
    20581 gctcgtccgg agccggagcc ggaggccgac cgggtccgtc cggctgccgg ggtggcacgt
    20641 cgccggtaga ccaggtac
//
