LOCUS       NZ_CP029254            24181 bp    DNA     linear   CON 23-OCT-2024
DEFINITION  Streptomyces spongiicola strain HNM0071 chromosome, complete genome.
ACCESSION   NZ_CP029254
VERSION     NZ_CP029254.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces spongiicola
  ORGANISM  Streptomyces spongiicola
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7180417)
  AUTHORS   Zhou,S. and Huang,X.
  TITLE     Complete genome sequence of the Type Strain of Streptomyces
            spongiicola HNM0071, the producer of staurosporine
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7180417)
  AUTHORS   Zhou,S. and Huang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-MAY-2018) Institute of Tropical Agriculture and
            Forestry, Hainan University, No 58, Haikou, Hainan 570228, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: ABySS v. 2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 850.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003122365.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 01:04:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,008
            CDSs (total)                      :: 5,921
            Genes (coding)                    :: 5,739
            CDSs (with protein)               :: 5,739
            Genes (RNA)                       :: 87
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 182
            CDSs (without protein)            :: 182
            Pseudo Genes (ambiguous residues) :: 0 of 182
            Pseudo Genes (frameshifted)       :: 47 of 182
            Pseudo Genes (incomplete)         :: 161 of 182
            Pseudo Genes (internal stop)      :: 9 of 182
            Pseudo Genes (multiple problems)  :: 32 of 182
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:10:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1877446
            Orig. end                         :: 1901627
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029254.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24181
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="8"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24181
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24181
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14181](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14181)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(80..1225)
                     /gene="hppD"
                     /locus_tag="DDQ41_RS08165"
                     /old_locus_tag="DDQ41_08165"
     CDS             complement(80..1225)
                     /EC_number="1.13.11.27"
                     /GO_function="GO:0003868 - 4-hydroxyphenylpyruvate
                     dioxygenase activity [Evidence IEA]"
                     /GO_process="GO:0006559 - L-phenylalanine catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006572 - tyrosine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hppD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006124896.1"
                     /locus_tag="DDQ41_RS08165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08165"
                     /product="4-hydroxyphenylpyruvate dioxygenase"
                     /protein_id="WP_109293885.1"
                     /transl_table=11
                     /translation="MTETLDHTPDTGRQADPFPVKGMDAVVFAVGNAKQAAYYYSTAFG
                     MKLVAYAGPETGSRETASYVLTNGSARFVFTSVIKASTDWGRFLAEHVAEHGDGVVDLA
                     IEVPDARAAYAYATEHGARGVQEPYELRDEHGTVVLAAVGTYGTTRHTLVDRSAYNGPY
                     LPGFSAADPIVEPPARRTFQAIDHCVGNVELGRMNEWVAFYNKVMGFTNMKEFVGDDIA
                     TEYSALMSKVVADGTLKVKFPINEPAVAKKKSQIDEYLEFYGGAGVQHIALATNDIVAT
                     VRMMRAAGVRFLDTPDSYYDTLGEWVGDTRVPIDTLRELKILADRDEDGYLLQIFTKPV
                     QDRPTVFFELIERHGSMGFGKGNFKALFQAIEREQEKRGNL"
     gene            1348..1821
                     /locus_tag="DDQ41_RS08170"
                     /old_locus_tag="DDQ41_08170"
     CDS             1348..1821
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947994.1"
                     /locus_tag="DDQ41_RS08170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08170"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_109293886.1"
                     /transl_table=11
                     /translation="MAIDHLDGRLIVLLAREPRIGVLEASRRLGVARGTVQARLDRLQS
                     NGVIRGFGPEVDPSALGYPVTAFATLEIKQGQGADVRAHLATVPEVLELHTTTGHGDML
                     CRLVARSNADLQRVIDRVVGFDGIVRASTAIVMENPVPLRIIPLVEQAAEDAR"
     gene            complement(2053..2850)
                     /locus_tag="DDQ41_RS08175"
                     /old_locus_tag="DDQ41_08175"
     CDS             complement(2053..2850)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004176 - ATP-dependent peptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947993.1"
                     /locus_tag="DDQ41_RS08175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08175"
                     /product="S16 family serine protease"
                     /protein_id="WP_109293887.1"
                     /transl_table=11
                     /translation="MFSRLSSLSRPRVLAVCALPVASLLAVAALAPLPFTVAQPGQTTN
                     VLGTDRGKPVITVSGAPVRQTQGQLRMTTIVATGPSTEVDLGDVADAWVRRDRAVLPRD
                     AVYPSGRSDEEIEEHNTAEMLKSQNSAVDAALGYLKEDPAKVKVTLHLADVGGPSAGLL
                     FSLGIVDKLAGDGAGGDLTGGRNIAGTGTIDADGKVGAVGGVALKTQAAARDGATVFLV
                     PKAECAVAEEQLPEGMTLIPVTELTDAVSSLRALERGGSVPKC"
     gene            complement(3167..3808)
                     /locus_tag="DDQ41_RS08180"
                     /old_locus_tag="DDQ41_08180"
     CDS             complement(3167..3808)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673009.1"
                     /locus_tag="DDQ41_RS08180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08180"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_109293888.1"
                     /transl_table=11
                     /translation="MTAETSQTLDRGLRVLKLLADTDHGLTVTELSNRLGVNRTVVYRL
                     LATLEQHALVRRDLGGRARVGLGVLRLGRQVHPLVREAALPALRSLAEDIGATAHLTLV
                     DGTEALAVAVVEPTWTDYHVAYRAGFRHPLDRGAAGKAILAARQGGLAEPSYILTHGEL
                     EAGASGAAAALVGVSGIEGSVGVVMLADSVPERVGPRVVDAAREVADALR"
     misc_feature    complement(3982..3996)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     gene            complement(4612..6396)
                     /locus_tag="DDQ41_RS08185"
                     /old_locus_tag="DDQ41_08185"
     CDS             complement(4612..6396)
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005316979.1"
                     /locus_tag="DDQ41_RS08185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08185"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_109293889.1"
                     /transl_table=11
                     /translation="MSTTASHHLSPAFPGRAPWGTANKLRAWQQGAMEKYVREQPRDFL
                     AVATPGAGKTTFALTLASWLLHHHVVQQITVVAPTEHLKKQWAAAAARIGVKLDPDYSA
                     GPLSKEYDGVAVTYAGVGVRPMLHRNRSEQRKTLVILDEIHHAGDSKSWGEACLEAFEP
                     ATRRLALTGTPFRSDTNPIPFVTYEEGDDGIRRSSADYTYGYGNALADGVVRPVIFLSY
                     SGNMRWRTKAGDEVAARLGEPMTKDAVSQAWRTALDPRGDWMPNVLRAADQRLGEVRKA
                     IPDAGGLVIAADQDSARAYAKLIREITGTKATVVLSDDAGASKRIDEFSGSQDRWMVAV
                     RMVSEGVDVPRLAVGVYATTISTPLFFAQAVGRFVRSRRRGETASVFLPTIPMLLGFAN
                     EMEVERDHALDRPRKEGEEDPYAESEKEMDEANKQQDEDTGEQDMLPFEALESDAVFDR
                     VMYNGAEFGMQAHPGSEEEQDYLGIPGLLEPDQVQLLLQKRQARQIAHSRRKPDADADL
                     LELPAERRPVVSHKELLELRKQLNTLVGAYVHQSGKPHGVIHTELRRVCGGPPSAEATA
                     GQIRERIKKVQEWATRMR"
     misc_feature    complement(6502..6517)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(6637..6651)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.68"
                     /tool="antismash"
     gene            complement(6831..8381)
                     /locus_tag="DDQ41_RS08190"
                     /old_locus_tag="DDQ41_08190"
     CDS             complement(6831..8381)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891591.1"
                     /locus_tag="DDQ41_RS08190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08190"
                     /product="MFS transporter"
                     /protein_id="WP_109293890.1"
                     /transl_table=11
                     /translation="MTALEPPDAARAGEPPAEQAAGVPGVVKTATATGTPGAATGTPAT
                     ATLTGGVLGRSLRALSVGIVSVVLLIAFEATAVGTAMPVAARELDGVPLYAFAFSAYFT
                     TSLFAMVLSGQWADRSGPLGPLGAGITAFGLGLLLSGTAATMWLFIAGRAVQGLGGGLV
                     IVALYVVVSRAYPEHLRPTIMAAFAASWVVPSVVGPLAAGTVTEQLGWRWVFIGIPALV
                     VVPLALALPAIRRRASGPVDPLAPVPALDRRRIRLALGISLGAAVLQYAAQDLRWFSLA
                     PAAAGAALLVPAALGLMPRGTFRAARGLPAVVLLRGVAAGSFIAAESFVPLMLVTQRGL
                     SPTLAGLSLAVGGATWALGSFVQSRPRLEAYRERLTVAGMVLVAAAIATAPSVLIPSVP
                     AWVVAVAWAWGCFGMGLVISSTSVLLLKLSAPAEAGTNSAALQISDGLSNVLLLAAGGA
                     AFAALGGGSAGGHGAAVAQAGAAGAGHTAAFAAVFLPMAAVALLGAWIATRLHERGPA"
     gene            complement(8733..9956)
                     /gene="fxlM"
                     /locus_tag="DDQ41_RS08195"
                     /old_locus_tag="DDQ41_08195"
     CDS             complement(8733..9956)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063718.1"
                     /locus_tag="DDQ41_RS08195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08195"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_109293891.1"
                     /sec_met_domain="PCMT (E-value: 7.2e-31, bitscore: 106.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTAQPSPEVLRNQLIDTIVRERVAGLYDPQVEEAMRTVPRHEF
                     LPAVSIETAYTNEAVTIKDNPAEDALPFSCASKPDVVFFMLVQLQAREGHRIFEIGAGT
                     GVNAAYLRRLVGPTGHVITGDIDSDVTAYARKTLDATGYGDIEVITRDGALGAEEYGPF
                     DRIIATVGVWDPSPAMRNQLTPGGRLVLPLRWRGLTRSVALVREPNRHRSDSVKVCGFL
                     PMIEETEEHSGYIDDDHLTRLFWDYDQPIDPTALRAAITQPATLAWSETTVGPVESFDG
                     VWLRMSATDPATCRITVKQPAVDAGLRRPANPNLGPALVEGDSMAYLTLARLPSEEGAV
                     PRFRLGAAAYGPAGETLAERLCTQITAWGDDRTAEPVISLYPAGTPDDQLTDGYVIEKP
                     STRMVISY"
     gene            complement(10001..11164)
                     /locus_tag="DDQ41_RS08200"
                     /old_locus_tag="DDQ41_08200"
     CDS             complement(10001..11164)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063717.1"
                     /locus_tag="DDQ41_RS08200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08200"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_109293892.1"
                     /sec_met_domain="LANC_like (E-value: 1.5e-42, bitscore:
                     144.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAEMQWEQSLYSGAPGIALLHIANAREGRAGWDTVHEWTTSMV
                     RHEVNADPSASGLFEGAPAVAFALHFANRPSYGPALVILDQHITDATRHRMRAAHARID
                     RGALPRLREFDVISGLTGLGSYCLSRTSRHPLLPEILSYLVRLTEPVRADGELLPGWWS
                     SDGPELRPSRAWPGGHGNLGLAHGITGPLAFLAIAMRRGVTVPGHANAIRYICAMLDQW
                     CQGTGAGAWWPTMLNREEWKSRTANQRVPERPSWCYGTPGITRALQLAALALGDRSRQH
                     GAETALAACATDDHQLARLTDASLCHGWAGLIRTVQRAADDADPDSPLATALPSLRGRM
                     RSHLDRVGAPTARGLMEGSDGIDLAQLDTTAHPTSAPHWDACLLLTG"
     gene            complement(11161..14181)
                     /locus_tag="DDQ41_RS08205"
                     /old_locus_tag="DDQ41_08205"
     CDS             complement(11161..14181)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063716.1"
                     /locus_tag="DDQ41_RS08205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08205"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_109293893.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.2e-194,
                     bitscore: 644.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.1e-13,
                     bitscore: 49.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7e-30, bitscore:
                     103.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRKLYEHTGTALLRAAAAPRTILPTWWPDPADAEGCMAWLMHVW
                     SRPELAGPIRQANPELGLSIDALRGRPVVAGKKLRRATMATARYLLRATGRPTPFGLFA
                     GVAPAALGPSAKVRWGTGHRAVARVDTMWLGDIINRLEACPDLLDRLDVVMNNLAARQG
                     GRLQVPHGGRHGASVVHTSAVRALQDCAAAPIRFGALVATLAGLFSGSDTGRVRSMLTE
                     LVRQGFLLSCLRAPMTETDPLGHLLEQLRKAEASTIESTAAILRDLEAVAAAIGHHNAI
                     PGPGQAGPREALTRKLRAMSEAGRAPLAVDLMLDADVEIPHSVAREMEAAAGALLRLTR
                     RPSGHGIWRDYQMAFWERYGVGTLVPLREVVDPAAGLGFPAEYPGSMMTPPVPQVSRRD
                     ERLLALAWQAVTDGSREIVLTDDMIDTLTDGQTAAPEPPHVEMCGRIHAASIEGLNQGD
                     FTLTVTPARSAGTLTSRFTPTAGGAGLEDVYQRVPAGTDGALRAQLSFPPLYLHTENVC
                     RIPAYLPHVIPLGEHRGPDETVIELDDLAVTATHSRLHLVSLSRRRVIEPQVFHAMALE
                     KQPPPLARFLAHLPRAFNAAWTGFDWGPEVLRLPYLPRVRFGRTVLCPARWYLTRADLP
                     TCGDLAAWHQALGQWRKRWDCPETVELRDDDRTLRLTLSEPLHAALLHAHLGRREDAAL
                     TEAAPAAGLGWIDRHAHEIALPLVTTRPPTAAAMSGPLPTVVNSALGHMPGSADSRWLY
                     AKIHTHPERMDEIITGHLPRLLDALPDRPAWWFLRYRSPHETDHLRLRLCIPSTGEYAA
                     VAAAVARWAEQLRAGAMAGRLVLDTYSPEIGRYGQGAVLEAAEAVFAADSTAVAAGLRH
                     VPGTLVHSTALVAAGMVDIARGFLGTNAAMDWLADQPTPIAATDRAVADQALRLARLDA
                     SLDLPGSNGDVAATWARRAAALAHYRSQFADDAEVSSILESLLHMHHNRALGLDRAGEK
                     ACRHLARQAARAWQALR"
     aSDomain        complement(13474..13725)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DDQ41_RS08205_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="9.90E-16"
                     /identifier="RREFam001.1"
                     /label="DDQ41_RS08205"
                     /locus_tag="DDQ41_RS08205"
                     /protein_end="236"
                     /protein_start="152"
                     /score="49.2"
                     /tool="antismash"
                     /translation="VVMNNLAARQGGRLQVPHGGRHGASVVHTSAVRALQDCAAAPIRF
                     GALVATLAGLFSGSDTGRVRSMLTELVRQGFLLSCLRAP"
     misc_feature    complement(14140..14142)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14249..14428)
                     /gene="fxlA"
                     /locus_tag="DDQ41_RS08210"
                     /old_locus_tag="DDQ41_08210"
     CDS             complement(14249..14428)
                     /codon_start=1
                     /gene="fxlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676476.1"
                     /locus_tag="DDQ41_RS08210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08210"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_109293894.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.6e-11, bitscore:
                     40.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVVTEKSVQPTTAEAVEDPFALDLTVTVDSGGLQMPSACGTGD
                     GCSSTCASSCASAV"
     CDS_motif       complement(14315..14428)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTAVVTEKSVQPTTAEAVEDPFALDLTVTVDSGGLQMP"
                     /locus_tag="DDQ41_RS08210_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14249..14314)
                     /prepeptide="core"
                     /locus_tag="DDQ41_RS08210_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-3.40"
                     /molecular_weight="1680.8"
                     /monoisotopic_mass="1679.6"
                     /core_sequence="SACGTGDGCSSTCASSCASAV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTAVVTEKSVQPTTAEAVEDPFALDLTVTVDSGGLQMP"
                     /leader_location="[14314:14428](-)"
                     /alternative_weights="1698.8"
                     /alternative_weights="1716.8"
                     /alternative_weights="1734.8"
                     /alternative_weights="1752.9"
     gene            complement(14507..15145)
                     /locus_tag="DDQ41_RS08215"
                     /old_locus_tag="DDQ41_08215"
     CDS             complement(14507..15145)
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="DDQ41_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08215"
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_109293895.1"
                     /transl_table=11
                     /translation="MTSPIPRTEQGAARDAAVTAVPPTRHPGYWDDVFAKGTQFRPVSE
                     DELGWFRAHTRPATGMTAIDVGCGRGDLAHTLAEWGLHTTGYDFSPLVVKEAAETYNHP
                     RLRYREHDFNAGAIPNDLAPEGADIVVCRLVMAFLDRARFLTDVRRWLRPDGVLYVMTP
                     VYEKQSDHAHRGVREEAIARLGDGWAETTRYDLCDDGCVTAVVLRGPQG"
     misc_feature    15156..15170
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.63"
                     /tool="antismash"
     misc_feature    15405..15420
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     gene            15691..16923
                     /locus_tag="DDQ41_RS08220"
                     /old_locus_tag="DDQ41_08220"
     CDS             15691..16923
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018565671.1"
                     /locus_tag="DDQ41_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08220"
                     /product="hypothetical protein"
                     /protein_id="WP_109293896.1"
                     /transl_table=11
                     /translation="MDKNLRLRAAMDETGYTQAELVEQLNLSLTAAGHRGTVSDRTVRY
                     WLTGKSRWPQQRQRDALEAVFGCPAVELGFVPPEGPLLRRTFLASTTAAGAALTIQPSN
                     AGRVGTSDVAALRAGLESLTGLDDKRGGHAALERSALAGAAECLSKQDKAGSQRVRQRL
                     LALAADFTATAAWSTIDARQLDRADSRLKEALYLARMADDSATELRVWNSLAMLAHQRK
                     EHGQAVDAGYAAQATGITRRDPLFASLAHARTAVGHSNRGDRQAALRSFGFAEEMLSKA
                     EPDTARPPWIAFYGPAELYALGAIVRDRLGFAAEAEASSYRALAALPKQFRRNRALATA
                     RLALAQLHQGEAEQACDTAASLFQLMAGAPLPGRMRSLMGDFHRDLLTLAPDATVAREW
                     GNRYRDQWSRT"
     gene            16920..17465
                     /locus_tag="DDQ41_RS08225"
                     /old_locus_tag="DDQ41_08225"
     CDS             16920..17465
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019061668.1"
                     /locus_tag="DDQ41_RS08225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08225"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_262508392.1"
                     /transl_table=11
                     /translation="MTVQLRQYKHDDLHEIRQTLIDVHADAYADQMDDPFVQRFPWFVD
                     HWGGNPGFSCLIGWDGSEPAGFAYGAPATAGSEWWREHVTEEPENPSTFSLSELTVRPK
                     WRKTGAAEQLHEALLASRDEALAVLLVDTTHPRVQALYESWQYRKVGERQPFPDSPVYA
                     VMLRSLSPALSRVSTTDG"
     gene            complement(17690..19993)
                     /locus_tag="DDQ41_RS08230"
                     /old_locus_tag="DDQ41_08230"
     CDS             complement(17690..19993)
                     /GO_function="GO:0043546 - molybdopterin cofactor binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947981.1"
                     /locus_tag="DDQ41_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08230"
                     /product="xanthine dehydrogenase family protein
                     molybdopterin-binding subunit"
                     /protein_id="WP_109293898.1"
                     /transl_table=11
                     /translation="MSNDAAIAAPAVDGPEQEPPAHGLGAALPQADTRAKTEGTFPYAS
                     DLWAEGLLWAAILRSPHPRARITAVDTSAAAGMPGVRAVVTHADVPGDAAYGRGVADRP
                     VFASDTVRHHGEAIAAVAADHPDTARLAAAAITVEYEVLEPVTDPEQAFAAEPLHPDGN
                     LIRHIPLSFGDPEAVGEVVVEGLYRVGRQDPAPIGAEAGLAVPRPDGGVELYTASTDPH
                     TDRDLAAACFGLDKERVKVVVTGVPGATGDREDPGFQIPLGLLALRTGCPVKLAATREE
                     SFLGHAHRHPTLLRYRHHASAEGRLLKVEAQILLDAGAYADASSESLAAAVAFACGPYV
                     VPHAFIEGWAVRTNNPPSGHMRGEGALQVCAAYEAQMDKLAAKLGLDPAEIRLRNVLAT
                     GDILPTGQTVTCPAPVAELLQAVRDFPLPPLPKDTPEDAWLLPGGPEGAGEPGAVRRGV
                     GYALGMVHMLGAEGTDEVSTATVKVQDGTATVICAAVETGQGFSTLARQIVQETLGIEE
                     VRVAPVDTDQPPAGPAAHGRHTWVSGGAVERAAKMVRTQLLQPLAHKFGMSTELLQIND
                     GKITSYDGVLSTTVTEAMDGKELWATAQCRPHPTEPLDDHGQGDAFVGLAFCAVRAVVD
                     VDVELGSVRVVEMAVAQDVGRVLNPAQLATRIEAGVTQGIGAALTENLRTARGLVRHPD
                     LTGYALPTALDAPDIRIVRLVEERDVVAPFGAKAASAVPVVTSPAAVAAAVRAATGRPV
                     NRLPIRPQAAVATP"
     gene            complement(19990..22332)
                     /locus_tag="DDQ41_RS08235"
                     /old_locus_tag="DDQ41_08235"
     CDS             complement(19990..22332)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891581.1"
                     /locus_tag="DDQ41_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08235"
                     /product="2Fe-2S iron-sulfur cluster-binding protein"
                     /protein_id="WP_174720270.1"
                     /transl_table=11
                     /translation="MSSEENEPRDTAPHGGGWQPIPQGGEYDAEATAFVRLPSDDMRDA
                     PLAAPGHGYVPPQIPPAAQDGRAAGWTVPEQAPDASHHWAAPGAGQPQNPYEPYAGQQP
                     YASHQAYPGSGLRAGGDSRAGGDLRAGGEQHGGYGPHGAYGAPDPYGARDPRGARDPQG
                     DGEPRTGHEAHPGPAPLGGGGFRGGHGAEGGGDPRAPRGAADGHDPHATGQWTFPEADE
                     PSSGPAGTADARDLTGQWTIPVAHGDLPEESGEFSASALAQWGGRTPPATLPGGAPAPW
                     ATTPDGGTPAGGTPLGGTPASGTPVPGAGYPATLPGGAPAPWAAEGYPAQEERAGSAAG
                     PRTEQRDEAGHGPHGEGAHPGAGDEASADAAPAPAAAAPDRSGSYPVEPSEADRPRAGD
                     MEAGHMEAGHMEAGHMEAGHVEAGHVEARDMEAGHAGHMEAGHVEADRTELDRTEFDGT
                     EPDRTEPDRADADHPGTTAHDASPEPGRAADTGDTGDTADTGVGDTADTADTGDTGDAV
                     SGGAVEVPEADAASQDPPDPARQDPPDAPPAGEAAAPDTSGAGAEGVGSATTATATATA
                     NDEHPHSSYVLRVNGADRPVTDAWIGESLLYVLRERLGLAGAKDGCSQGECGACNVQVD
                     GRLVASCLVPAATAAGSEVRTVEGLAADGEPSDVQRALAACGAVQCGFCIPGMAMTVSD
                     LLEGNHAPTELETRQALSGNLCRCSGYRGVLDAVREVAAERGASAAAAAEAADGSREAA
                     QDAARIPRQAPPGAGSVQPHPHDGGMV"
     gene            complement(22329..23207)
                     /locus_tag="DDQ41_RS08240"
                     /old_locus_tag="DDQ41_08240"
     CDS             complement(22329..23207)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018517908.1"
                     /locus_tag="DDQ41_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08240"
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_109293899.1"
                     /transl_table=11
                     /translation="MTTHAPQAAQSVTLPASLGEAVAALTDMPAAVPVAGGTDLMAAVN
                     KGRLRPAGLVGLGRINEIRGWQYQDGHALLGAGLTHSRMGRPDFAALIPALAAAARAAG
                     PPQIRNAGTLGGNIVTSAPTGDTLPVLAALEADLVIAGPGGVTREIPVSHLLAGRELLG
                     PAELVGYVRVPLLHAPQVFLKATGRTGPGRATASVAVVLDPARRGVRCAVGAIAPMPLR
                     PLEAERWIASLIDWDAERGLAPEALAAFGEYVAAACIPDQEGDEQLPPAVLHLRRVVAA
                     LARRALGRALS"
     misc_feature    23254..23272
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.04"
                     /tool="antismash"
     misc_feature    23423..23438
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            complement(23825..24037)
                     /locus_tag="DDQ41_RS08245"
                     /old_locus_tag="DDQ41_08245"
     CDS             complement(23825..24037)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004978947.1"
                     /locus_tag="DDQ41_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DDQ41_08245"
                     /product="DUF4287 domain-containing protein"
                     /protein_id="WP_109293900.1"
                     /transl_table=11
                     /translation="MTEQPKGPAGYFPSIEQKYGRPVAEWKDLIRSSPLTRHGELVSWL
                     KAEHGLGHGHANALVAHTLAEDGGK"
ORIGIN
        1 tgccacgacg ccacgcggcc ccacgggtca ggctccgtgg ggccgcgggg ccggaggcgg
       61 gctccgtacg ggctggtggc tagaggtttc cgcgcttctc ctgctcgcgc tcgatcgcct
      121 ggaagagcgc cttgaagttg cccttgccga agcccatcga gccgtgcctt tcgatgagtt
      181 cgaagaagac cgtcggccgg tcctgcacgg gcttggtgaa gatctgcagc agatagccgt
      241 cctcgtcgcg gtccgcgagg atcttcagct cgcgcagggt gtcgatcggg acccgggtgt
      301 cgccgaccca ctctccgagc gtgtcgtagt aggagtcggg cgtgtccagg aacctcaccc
      361 cggccgcccg catcatgcgc acggtggcga cgatgtcgtt ggtggccaaa gcgatgtgct
      421 ggacgcccgc cccgccgtag aactcgaggt actcgtcgat ctgcgacttc ttcttcgcga
      481 ccgcaggttc gttgatcggg aacttcacct tcagggtgcc gtccgcgacg accttggaca
      541 tcagcgccga gtactcggtc gcgatgtcgt cgccgacgaa ctccttcatg ttggtgaaac
      601 ccatgacctt gttgtagaag gccacccact cgttcattct gccgagttcg acgttgccca
      661 cgcagtggtc gatggcctgg aaggtccgcc tggcgggggg ctcgacaatg gggtcggcgg
      721 ccgagaagcc cggcaggtag gggccgttgt aggcggatcg gtcgacgagg gtgtggcggg
      781 tcgtgccgta tgtgccgacg gcggcgagga cgaccgtgcc gtgctcgtcc ctgagttcgt
      841 acggctcctg gacgccgcgc gcgccgtgct cggtggcgta cgcgtaggcg gcgcgggcgt
      901 ccggcacctc gatggccagg tcgacgacac cgtcaccgtg ctcggcgacg tgctcggcga
      961 ggaaccggcc ccagtcggtg gacgccttga tgacggaggt gaacacgaac cgcgcggagc
     1021 cgttggtcag cacgtaggaa gcggtctccc ggctaccggt ctccggcccc gcgtaggcga
     1081 cgagcttcat cccgaaggcc gtggagtagt agtacgcggc ctgctttgcg ttgccgacgg
     1141 cgaagacgac cgcgtccatt cccttcaccg ggaaggggtc ggcctgcctg ccggtgtcag
     1201 gggtgtgatc cagggtctca gtcatgacgg cagactcccg ccgatccaca agatgcgcaa
     1261 tagttgctgt attcactggg caatatgccg agccggtgtc cgatttactc gggctacctg
     1321 tacaggatga ctacataagg ggctgatgtg gcgatcgatc atctggacgg caggctgatc
     1381 gtgctgctcg cacgggagcc gaggatcggt gtcctggagg cgtcccgccg gctgggggtg
     1441 gcacgcggca ccgtgcaggc gcggctggac aggctccagt cgaacggggt catccgcggt
     1501 ttcgggcccg aggtcgaccc gtccgcgctg ggctacccgg tgaccgcgtt cgcgacgctg
     1561 gagatcaagc aggggcaggg ggccgacgta cgtgcccacc tcgccaccgt tcccgaggtg
     1621 ctggaactgc acacgacgac gggtcacggc gacatgctgt gccggctggt cgcgcggtcc
     1681 aacgcggacc tccagcgggt gatcgaccgg gtcgtggggt tcgacggcat cgtgcgggcg
     1741 tccaccgcga tcgtgatgga gaacccggtc ccgctgcgga tcatcccgct ggtggagcag
     1801 gccgcggagg acgcccgctg aaccagccga ccctacggcc ccgaccgccc cgacggcccc
     1861 ggcttccctc gccggcatcg gacgtacggc gcccccgtga cggtccccgt ccgcagatcc
     1921 cggcacggcc acccaggtcg ccaaggcccg gggccaccac ggaccgagac gcaccacaac
     1981 accacgcccc ccggaacaca ccacgccccc gggaacacag caaggccccg ggaacacacc
     2041 acgccccgcc ggtcagcact tcgggacgct gccgcccctc tccagcgccc tgagcgacga
     2101 caccgcgtcc gtcagctcgg tgaccgggat cagcgtcatg ccctcgggca gctgctcctc
     2161 ggccacggcg cactcggcct tgggcacgag gaacacggtc gcgccgtcgc gcgccgccgc
     2221 ctgggtcttc agcgcgaccc cgccgaccgc gccgaccttg ccgtcggcgt cgatggttcc
     2281 cgtacccgcg atgttccggc cgccggtgag atcgccgccc gcgccgtcgc ccgccagctt
     2341 gtccacgatg ccgagggaga agaggagccc ggcgctcgga ccgccgacat cggcgagatg
     2401 cagggtgacc ttcaccttcg cgggatcctc cttgagatac cccagggcag cgtctaccgc
     2461 gctgttctgg gacttcagca tctcggcggt gttgtgctcc tcgatctcct cgtccgaccg
     2521 cccggagggg tagacggcgt cgcgcggcag cacggcgcgg tccctgcgca cccacgcgtc
     2581 cgccacgtcg ccgagatcga cctcggtcga gggaccggtc gccacgatgg tcgtcatccg
     2641 caactgcccc tgggtctgcc gtacgggtgc tccggagacg gtgatcaccg gcttgccccg
     2701 gtcggtcccc agcacgttcg tggtctgccc gggctgggcc acggtgaacg gcaggggcgc
     2761 gagcgcggcg accgcgagca gcgatgcgac cgggagggcg cagacggcga gaacccgggg
     2821 gcgggagaga ctcgagaggc gagagaacac cctgtcaatg tatcggtccg cccgatgcgg
     2881 ccggatcggg cccggacccg gcccgaccct gcggggaccg gcccgggacc ggccggggac
     2941 cctgagggga ccgggtgggg accggcccgg gaccgggtgg gcagcggccc gaaacgggcc
     3001 cgcggccgcg gccgggtggg gaccgggcgg cgaccgggtg gcggccttcc gcggcagggg
     3061 acgaaggcga ccaggcggtg ggcgaacggg cggcggccta ccgggcggcg catcggcgtg
     3121 cggaggccga ctgacccggc agctccctcc ccggccggcc gcccgctcag cgcagtgcgt
     3181 ccgcgacctc gcgtgccgcg tccaccaccc tggggcccac ccgctccggg acggagtccg
     3241 ccagcatgac gacgccgaca ctgccctcta tgccgctcac cccgacgagt gctgcggcgg
     3301 ccccgctggc acccgcctcc agttcaccat gagtgaggat gtacgagggc tcggcaagac
     3361 ccccctgccg tgcggcgagg atcgccttcc ccgcggctcc gcggtccagc gggtggcgga
     3421 agccggcccg gtacgccacg tggtagtccg tccaggtcgg ttcgacgacc gccaccgcga
     3481 gcgcctccgt cccgtcgacc agtgtgagat gggcggtcgc gccgatgtcc tcggcgaggg
     3541 agcgcagcgc cggcagcgcc gcctcccgca ccagcgggtg cacctgacgg ccgaggcgga
     3601 gcacgccgag ccccacccgg gctcggcctc ccaagtcgcg tcgcaccagg gcgtgttgct
     3661 cgagtgtggc gagcagtcgg tagacgaccg tcctgttgac accgagccgg ttggacagct
     3721 cggtcacggt cagcccgtgg tcggtgtcgg cgagcagttt gaggacgcgc agtcctctgt
     3781 cgagcgtctg ggaggtctcc gcggtcacga cgccctctcc ttcgaggtga gtgcggcgac
     3841 gctctcgcgg ccagcggcac cggtcccatc ggcgacgcac ggagaggccg ccggcaggcc
     3901 atgcacaccg gctgcgctcc gcggcggcgc tgccacgggg cgtttcattt ccggggacag
     3961 tagcgaagcc ggttcgctca gcggaagacc tcgtccagaa tccgggcacc gaacgaccct
     4021 gccgtccgct atcggcacgc aagtcgggac gaccagcgac ttcacgcgac acatcactct
     4081 tcagcctccg ccgaagtggg acaccgaacc acgcctcgac accacgccgc gacgcggccc
     4141 ggacgcacgg cccgaagggt gggcgggtgc cgggtagcgg tacaggcccg ggggaacaac
     4201 cgaaacgggg cgcacgggac ccagggcgcg ggacgggacc cagagtgcgg gacccgaggc
     4261 gggaagccgc accgcgtgga gaaggcagcg cccgcggaac gcaccgcccg gggagcaccg
     4321 aacccggggc cgaaccggcc cggcccggtc cgaaccggca ggcgcggggg ccgaaccgcc
     4381 cgggtcatac aggcccgggc acacgcagcg cccgcaccgg ccgggcggcc gaaccggccc
     4441 ggcccgaacc ggcaggcgcg gggcggggtt acgggatcag cggaacaggg tcaggtgttg
     4501 cgcggaaccg gcgcgcggtg gccggtgcgc gccggtccgg cggtgggccg gcgcacacga
     4561 gcgcgtggcc cgggagccgc cgtacgcacc cggccccgtc accgggtgcg ctcaccgcat
     4621 ccgggtggcc cactcctgca ccttcttgat ccgttcccgg atctggcccg ccgtcgcctc
     4681 cgcgctcggc ggccctccgc acaccctccg cagctcggtg tggatcaccc cgtgcggttt
     4741 gccgctctgg tggacgtacg cgcccaccag cgtgttcagc tgcttcctca gctccagcag
     4801 ctccttgtgg gagaccaccg gacggcgctc cgcgggcagt tccagcaggt ccgcatccgc
     4861 gtccggcttc cggcggctgt gcgcgatctg ccgcgcctgc cgcttctgca gcagcagttg
     4921 cacctggtcc ggctccagca ggcccgggat cccgaggtag tcctgctcct cctcgctgcc
     4981 cgggtgggcc tgcatgccga actcggcgcc gttgtacatc acccggtcga agacggcgtc
     5041 ggactccagc gcctcgaagg ggagcatgtc ctgctcgccg gtgtcctcgt cctgctgctt
     5101 gttggcctcg tccatctcct tctcggactc ggcgtagggg tcctcctccc cttccttcct
     5161 cgggcggtcg agcgcgtggt cccgctcgac ctccatctcg ttcgcgaagc ccagcagcat
     5221 cgggatcgtc ggcaggaaga cggacgccgt ctcgccgcgc cgccgggagc gcacgaaacg
     5281 gccgacggcc tgcgcgaaga acaggggcgt ggagatggtc gtggcgtaca cgccgaccgc
     5341 gagccggggg acgtcgacgc cctcggacac catccggacg gcgaccatcc agcggtcctg
     5401 gctcccgctg aactcgtcga tgcgcttcga ggcgcccgcg tcgtcggaca gcacgacggt
     5461 cgccttggta ccggtgatct cccggatgag cttggcgtag gcgcgcgccg agtcctggtc
     5521 ggcggcgatg acgagaccgc ccgcgtccgg gatggccttc cttacctcgc ccagccgctg
     5581 gtcggcggcg cggagcacgt tcggcatcca gtcgccgcgc ggatcgagcg cggtgcgcca
     5641 cgcctgcgag acggcgtcct tggtcatcgg ctcgccgagc ctggcggcga cctcgtcgcc
     5701 cgccttggtg cgccagcgca tgttgccgct gtaggacagg aagatcacgg gacggacgac
     5761 gccgtcggcg agggcgttgc cgtagccgta ggtgtagtcg gcggacgacc ggcggatgcc
     5821 gtcgtcgccc tcctcgtagg tgacgaaggg gatggggttg gtgtcggagc ggaagggcgt
     5881 accggtcagg gcgagtctgc gggtggcggg ttcgaaagcc tccaggcacg cctcgcccca
     5941 cgacttggag tcgccggcgt ggtggatctc gtcgaggatc acgagggtct tgcgctgctc
     6001 gctgcggttg cggtggagca tcgggcgtac gccgacaccg gcgtaggtga cggcgacccc
     6061 gtcgtactcc ttgctgagcg gaccggcgct gtagtccggg tccagtttga cgccgatgcg
     6121 cgcggcagcg gcggcccact gcttcttcag gtgctcggtc ggcgccacca cggtgatctg
     6181 ctgcacgaca tggtggtgca gcagccagga ggcgagggtc agcgcgaacg tggtcttgcc
     6241 ggcgccgggg gtcgccaccg cgaggaagtc acgcggttgt tcccggacgt acttctccat
     6301 ggcgccctgc tgccaggcac gcagcttgtt cgccgtgccc cagggggcgc ggccgggaaa
     6361 ggcgggtgag aggtggtggg aggcggtagt agacacggtc tccggttcga ggcagggctg
     6421 cggcgttacg tacgacaacc gggccaccct accggtgcgg ccgctgcccg gggggccgca
     6481 ccgggctgtg cggggacggg gtgagacccg cctcacagcg gcggcccggg gcacccgggc
     6541 ccgggcccgc cgcccgtgtt cacggagtgc gcagcgcggc gccggtcaga gccggatcgg
     6601 gtcactcggg ccgggtgggc gtccggccgc ggggcagggg ccggacgtcc cgggactccc
     6661 cgacgtccga aagcgcggaa gcacgggagc acgggagcac gggagcccgg aggccgggag
     6721 cccgggagcc cggaggaggt acaggagccc cggaggaggt acaggagccc cggaggaaat
     6781 gcgggagccc cggagcccga aggaaatgcg ggagtacggg agtacgggag tcaggccggg
     6841 cctcgctcgt gcagccgggt ggcgatccag gcgccgagca gcgcgaccgc ggccatgggc
     6901 aggaacaccg cggcgaaggc ggccgtgtgg ccggcgcccg ccgccccggc ctgggcgacc
     6961 gcggcgccgt ggccgcccgc cgagcccccg cccagggcgg cgaaggctgc gccgcccgcg
     7021 gccaggagga ggacgttgga cagcccgtcg gagatctgga gggcggcgga gttggtgccg
     7081 gcctccgccg gggccgacag cttcagcagc agcacgctgg tggaggagat gaccaggccc
     7141 attccgaagc agccccaggc ccaggcgacc gcgacgaccc atgccggtac ggaggggatc
     7201 agcacgctgg gcgccgtcgc gatcgccgcc gcgacgagca ccatgcccgc gacggtcaga
     7261 cgctcccggt acgcctcgag ccgcggccgg gactggacga acgaccccag cgcccaggtc
     7321 gccccgccca ccgcgagcga cagtccggcc agcgtcggcg acagcccgcg ctgggtgacc
     7381 agcatcagcg gtacgaagga ctccgcagcg atgaacgacc cggcggccac tccgcgcagc
     7441 agcaccaccg ccggcagccc gcgcgccgcc cggaacgtgc cgcgcggcat cagaccgagc
     7501 gcggcgggca cgagcagcgc ggcccccgcg gcggccgggg ccagcgagaa ccaccgcagg
     7561 tcctgggctg cgtactggag caccgcggcg ccgagggaga tgcccaacgc cagccggatc
     7621 ctgcgtcggt cgagcgccgg gacgggggcc aggggatcca ccgggcccga ggcccggcgc
     7681 cgtatcgcgg gcagcgccag cgcgagcggg accacgacga gggcggggat gccgatgaac
     7741 acccagcgcc agccgagctg ttcggtgacc gtgccggccg cgagcggtcc gacgacggag
     7801 gggaccaccc agctcgcggc gaacgccgcc atgatcgtcg gcctcaggtg ctccgggtag
     7861 gcccggctga cgacgacgta cagcgcgacg atcaccagtc cgccgcccag cccctggacg
     7921 gcccggccgg cgatgaacaa ccacatcgtg gcggccgtcc cggacagcag cagccccagc
     7981 ccgaaggcgg tgatcccggc gcccagcggc ccgagcgggc cgctgcggtc ggcccactgc
     8041 ccggagagca ccatcgcgaa caggcttgtc gtgaagtacg cggagaaggc gaacgcgtac
     8101 agcggcaccc cgtccagctc ccgcgccgcc accggcatgg cggtaccgac ggcggtcgcc
     8161 tcgaaggcga tcagcaggac gacggagacg atgccgacgc tgagggcgcg caggctgcgc
     8221 ccgagcacgc cgccggtgag ggtggcggtg gcgggcgtgc cggtcgcggc cccgggcgtg
     8281 ccggtggcgg tggcggtctt gacgacgccg ggaacgccgg cggcctgctc ggccggcggc
     8341 tcaccggcac gggccgcgtc aggtggttcg agggctgtca cgcgctccag agtaagggcc
     8401 gtggtctggg atggcccctg tcgtggggtg ggggttcggc tcggccgtcg gtcctaggcc
     8461 gggtcggggc ggttcttcgc cggtccgctc tccagcggct cggcgaagag gtccgcgaag
     8521 ggcgtgaacg tgagttggtc acttaccaca ggaatcggca cggtgggcgg ggcctaccgg
     8581 cggcgataca gcggatcgtg gccgagcgtc aaggcctggc cgcctctgtg gacggagtga
     8641 ccggccggag cgttacaccc gggtcgtttt cggtgtgact gcgcacgtga ggccccgacg
     8701 catgtcgggg cctcaacgga gcagggggac ggtcagtatg agatcaccat gcgggtcgag
     8761 ggcttctcga tgacgtatcc gtcggtgagc tggtcgtctg gcgttccggc cgggtacagg
     8821 ctgatcacgg gctcggcggt tcggtcgtcg ccccatgccg tgatctgcgt gcacaggcgc
     8881 tccgccagtg tctctccggc cgggccgtat gcggcggcgc cgagtcggaa ccggggcact
     8941 gcgccttcct cggacgggag gcgtgcgagg gtgaggtacg ccatcgagtc gccttccacg
     9001 agggcggggc cgaggttggg attcgcgggg cggcgcaggc ccgcgtcgac ggcgggctgc
     9061 ttgacggtga tgcggcaggt tgccgggtcg gtggcggaca tgcgcagcca caccccgtcg
     9121 aaggattcga ccggcccgac ggtcgtctcg ctccacgcca gggtcgccgg ctgagtgatg
     9181 gcggcgcgca gggcggtggg atcgatgggc tggtcgtagt cccagaagag gcgggtcagg
     9241 tgatcgtcgt cgatatagcc gctgtgttcc tccgtctcct cgatcatggg caggaagccg
     9301 cacaccttga cggagtcgga ccggtgccgg ttcggttcgc ggaccagggc gacgctgcgg
     9361 gtcaggcctc gccagcggag cggaagcacg agcctgccgc cgggggtgag ctggtttcgc
     9421 atggcggggc tggggtccca gacgccgacg gtggcgatga tgcggtcgaa ggggccgtac
     9481 tcctcggctc ccagggcgcc gtctcgggtg atgacttcga tgtcgccgta gccggtggcg
     9541 tcgagcgtct tgcgggcgta ggcggtgacg tcgctgtcga tgtcgccggt gatgacgtgg
     9601 ccggtggggc cgaccaggcg ccgcaggtag gcggcgttca ccccggtgcc ggcgccgatc
     9661 tcgaagatgc ggtggccttc gcgtgcctgg agctggacga gcatgaagaa gacgacgtcg
     9721 ggcttggatg cgcagctgaa gggcagggcg tcctcggccg ggttgtcctt gatggtcacg
     9781 gcctcgttgg tgtaggcggt ctcgatgctg acggccggga ggaactcgtg gcggggcacc
     9841 gtccgcatgg cctcttcgac ttgcgggtcg tacagcccgg cgacgcgttc ccgcacgatc
     9901 gtgtcgatga gctggttgcg caggacttcg ggcgagggct gtgcggtggt gttcatggac
     9961 ttccttccga gtggtagcgg tgcggtggtc gtcgggccgg tcagccggtc aagaggaggc
    10021 aggcgtccca gtggggggca gatgtggggt gggcggtcgt gtcgagctgg gccaggtcga
    10081 taccgtcgga gccttccatc agccccctgg cggtcggggc gcccacgcgg tccaggtggc
    10141 tgcgcatccg gccgcgcagc gagggcaggg ctgtggccag tgggctatca gggtcggcat
    10201 cgtcggcagc tctctgaacg gtgcgtatga ggccggccca gccatggcag agggaggcgt
    10261 cggtgagccg ggcgagttgg tggtcatcgg tggcgcaggc ggcgagtgcc gtttcagcgc
    10321 cgtgttgccg tgaccggtca ccgagtgcga gagcggcgag ttgaagcgcg cgggtgatcc
    10381 ccggggtgcc gtagcaccag gacgggcgtt cgggaactcg ttggttcgcc gtgcggctct
    10441 tccactcctc gcggttgagc atagtgggcc accaggctcc cgctcctgtc ccttggcacc
    10501 actggtccag catggcgcag atgtagcgga tcgcgttggc gtgcccgggg acagtgacgc
    10561 cgcggcgcat cgcgatggcc aggaaggcga gcgggccggt gatgccgtgg gccaggccca
    10621 agttgccgtg tccgcccggc catgcgcggc tcggccgcag ttcggggccg tcgctggacc
    10681 accagcccgg caggagctcg ccatcggccc tgaccggctc cgtcaggcgc accaggtagg
    10741 acaggatctc gggcagcagc gggtgccgac tcgtgcggga caggcagtag ctgccgagcc
    10801 cggtcaggcc gctgatgacg tcgaactcgc gcagccgcgg cagcgcgccg cggtcgatgc
    10861 gcgcgtgggc tgccctcatc cgatgtcggg tggcgtcggt gatgtgctga tcgagaatga
    10921 cgagcgccgg cccgtacgac ggacggttcg cgaagtggag ggcgaacgcg acggcgggtg
    10981 cgccctcgaa cagcccggag gcggacgggt cggcgttcac ctcgtggcgg accatagagg
    11041 tggtccactc gtggacggtg tcccatccag cccggccttc gcgggcgttg gcgatgtgca
    11101 gcagcgcgat acccggtgcg ccggagtaca gcgactgctc ccactgcatc tccgcagcgg
    11161 tcatcggagg gcctgccagg cgcgggcggc ctgccgagcc aggtggcggc aggccttctc
    11221 cccggcccga tccagaccga gcgctcgatt gtggtgcatg tgcagcagcg actccaggat
    11281 cgagctcacc tcggcgtcgt cggcgaactg gctgcggtag tgcgccaggg ccgccgccct
    11341 tcgggcccac gtggcggcga cgtcaccgtt gctcccgggc aggtccagcg atgcatcgag
    11401 ccgggccagg cgaagggcct ggtcggcaac cgcccggtcg gtggccgcga tcggcgtggg
    11461 ctggtcggcg agccagtcca tggcggcgtt ggtgccgagg aatccgcggg cgatgtccac
    11521 catgcccgcg gcgaccaggg cggtggaatg tacgagggtg ccgggcacat ggcgcaggcc
    11581 ggcggcgaca gcggtggagt ccgcagcgaa cacggcttcg gccgcttcca gtacggcgcc
    11641 ttgcccgtag cggccgatct cggggctgta ggtgtcgagg acgagtcggc cggccatggc
    11701 tccggcgcgg agctgctccg cccagcgggc gacggcggcc gcgacggcgg cgtactcgcc
    11761 cgtgctcggg atgcacaggc gcagccggag gtgatcggtc tcgtgcgggc tgcgatagcg
    11821 caggaaccac caagcgggcc tgtcgggaag ggcgtcgagg agccggggaa ggtggccggt
    11881 gatgatctcg tccatccgct cggggtgagt gtggatcttc gcgtagagcc atcgggagtc
    11941 cgcggagccg ggcatgtgcc cgagcgcgct gttgaccact gtcggtagcg gaccggacat
    12001 cgccgcggcg gtcggcgggc gagtggtgac cagcggcagg gcgatctcgt gcgcgtgccg
    12061 gtcgatccac ccgaggcccg cggcgggggc ggcctcggtg agggcggcgt cctcgcgccg
    12121 accgagatgg gcgtgcagga gcgccgcgtg cagtggctcg ctcagggtga gccgcagggt
    12181 gcggtcgtcg tctcgcagct ccaccgtttc ggggcaatcc cagcgtttgc gccactggcc
    12241 gagagcctga tgccaggcag cgaggtcgcc gcaggtggga aggtcggcgc gggtgaggta
    12301 ccagcgggcc gggcacagga cggtgcgccc gaagcggact ctgggcaggt acgggagccg
    12361 gaggacttcg gggccccagt cgaaacccgt ccacgcggcg ttgaacgcgc gcggcaggtg
    12421 ggcgaggaac ctggccagcg gcgggggctg cttctccagc gccatcgcgt ggaagacctg
    12481 cggctcgatg acgcggcggc gggagaggct gaccagatgc agccggctgt gtgtcgcggt
    12541 gacggcgaga tcgtccagct cgatcaccgt ctcgtccggg ccgcggtgct caccgagggg
    12601 gatgacatgg ggcaggtagg cggggatgcg gcagacgttc tccgtatgga ggtagagcgg
    12661 ggggaacgag agctgggcgc gcagtgcgcc gtcggtgccc gcgggaacac gctggtagac
    12721 gtcctccagg cccgcgcctc cggctgtcgg ggtgaagcgg gacgtgagcg tgcccgcgga
    12781 gcgggccggg gtgacggtga gggtgaagtc gccctggttc aacccctcga tgctcgcggc
    12841 gtggatgcgt ccgcacatct ccacgtgcgg cggctcggga gcggcggttt gcccgtccgt
    12901 cagggtgtcg atcatgtcgt cggtgagaac gatctcccgg ctgccgtcgg ttacggcctg
    12961 ccaggcaagc gccaggagac gctcgtcccg gcgcgagacc tgcggcacgg gcggcgtcat
    13021 catgctgccg gggtactcgg cggggaaccc gagacctgcg gccgggtcca cgacctcccg
    13081 aagcggcacg agcgtcccca cgccgtaccg ctcccagaaa gccatctggt agtcgcgcca
    13141 gatgccgtga ccagaggggc ggcgggtcag ccgcagcagg gcgccggccg cagcctccat
    13201 ctcgcgggcg acgctgtggg gaatctcgac atcagcgtcg agcatgaggt cgacggccag
    13261 cggcgcacgg ccggcctccg acatcgcgcg cagcttccgg gtcagcgcct cgcggggccc
    13321 tgcctggccc ggccccggga tcgcgttgtg gtggcctatc gcggccgcga cggcttcgag
    13381 atcccgcagg atcgccgcgg tggactcgat cgtgctcgcc tccgccttgc gcagctgctc
    13441 caggaggtgg ccgagtggat cggtctcggt catcggcgcg cgcaggcagg acaggaggaa
    13501 gccctggcgg acgagctcgg tcagcatgct gcggaccctg ccggtgtcac tgccggagaa
    13561 gagacccgcg agggtggcga ccagcgcacc gaagcggatc ggggcggctg cgcagtcctg
    13621 caaggcgcgt accgcgctgg tgtgcacgac gctcgcaccg tgccggcctc cgtgcggcac
    13681 ctgaaggcgc ccgccttgcc gggcggcaag gttgttcatc acgacgtcca ggcggtccag
    13741 cagatcgggg cacgcctcca gccggttgat gatgtcgccg agccacatcg tgtcgacgcg
    13801 ggcgaccgcc cgatgcccgg tgccccaccg gaccttggcc gacgggccca gcgcagcggg
    13861 ggcaacgccg gcgaacagtc cgaacggcgt gggccggccg gtggcacgca gcaggtaccg
    13921 ggcggtcgcc atcgtggccc gccgcagctt cttgccggca accaccggcc tgccgcgcag
    13981 cgcatcgatg ctgagaccga gctcggggtt cgcctggcgg atcgggccgg cgagctccgg
    14041 gcgggaccag acgtgcatca gccaagccat gcacccctcg gcgtcggcag ggtcgggcca
    14101 ccatgtgggc aggatggtcc gcggcgcggc cgcggcccgt aacagtgccg tgcccgtgtg
    14161 ctcgtacagc ttcctgctca tgaatcagcc tcctccacgg tgcggagggc cggggcgctg
    14221 ccccggccct ccgagacaat gcgatgggtc agacggcgct cgcgcaggac gaggcgcagg
    14281 tggaggagca tccgtcgccc gtgccgcagg cggacggcat ctgaaggccg ccagagtcga
    14341 cggtgacggt caggtcgagc gcgaacgggt cctccacggc ctccgcagtg gttggctgaa
    14401 cggacttctc ggtcacgaca gcggtcatgg cagctccttc tcagacgggt gaacgtgctc
    14461 ttgcggtggt acgccgcccc agcccgaagg cgcgggacgg agctcatcag ccctgtgggc
    14521 cgcgcaggac gacggcggtc acgcatccgt cgtcgcacag gtcgtagcgg gtggtctccg
    14581 cccagccgtc gccgagtctc gcgatcgctt cctcgcgcac accgcggtgc gcgtggtcgg
    14641 actgcttctc gtagacgggc gtcatgacgt acagcacgcc gtcagggcgg agccatcggc
    14701 gcacgtcggt caggaaccgg gcccgatcga ggaaggccat caccaggcgg cacacgacga
    14761 tgtccgcgcc ttccggggcg aggtcgttgg ggatcgcgcc ggcgttgaag tcgtgctcgc
    14821 ggtagcgcag cctcgggtgg ttgtacgtct cggcggcctc cttgaccacc agcggcgaga
    14881 agtcgtagcc ggtcgtatgc aggccccact cggccaatgt gtgcgcgagg tcgccgcggc
    14941 cgcatccgac gtcgatcgcg gtcatgccgg tcgcgggccg cgtgtgggcg cggaaccaac
    15001 ccagttcgtc ctcgctgacg ggccggaact gcgtgccttt ggcgaagacg tcatcccagt
    15061 aacccgggtg gcgggtcggc ggcacagccg tcacagccgc gtcccgtgct gcgccctgct
    15121 ctgtgcgggg gatcgggctg gtcatcaggg ggttctcctc attctgcgta cagggcgagc
    15181 ggcactacca gcccggcgac ggtgaggacg acgaggatct gtaagcacca ctgccgccag
    15241 gcccatcgac gctcgtccat ccagcgcatt gggcacttca cgtcgcggcc tcgggcacga
    15301 cgagcgctgt gaaacagtgg cggtcggcat tgagctcgtc ccgcagcctc ttcagccatg
    15361 ccgggtgcta tcgggatgtg gggcgcagag ccgctggtga agcgtgtgaa ctcgttctca
    15421 cggtccatcc acgacgtgtc ccgagccgcc ctcgtcgtgc tgcgcatcgt catctccgtc
    15481 gctgtgggga gcgggcggac tgccgccacg tcggcggtcc gccccggggg agggccgcca
    15541 tggagaacgg ccgcccctca tacaactgcc gaagttccgg ccagggcagg aaatagcggg
    15601 cgcgcgtcgg tcgccggcga ccggaaattc cgggccggcg cctctgccat cagcctcaac
    15661 aggggatgac gatgtggcta cggtgagtgc gtggacaaga atctccggct cagagcggcc
    15721 atggacgaaa ccggctacac ccaggcggag ttggtcgagc agctgaacct gtcgctgacg
    15781 gcggccggcc accgcgggac cgtcagcgac cggaccgtgc gctactggct gaccggaaaa
    15841 tctcgatggc ctcagcagcg acaacgggac gcgttggagg cagtattcgg gtgtccggcc
    15901 gtcgaactcg gctttgttcc cccggagggt ccattgctcc gccgtacctt cctcgcgtcc
    15961 accacggccg caggggcagc gctcacgatc cagccctcca acgcgggccg cgtggggaca
    16021 tccgacgtgg ctgctctccg cgccggcctg gagagcttga ccggcctgga cgacaagcgc
    16081 ggcggacacg ccgcccttga gcggtcagcc cttgccggcg cggccgaatg cctgagcaag
    16141 caggacaagg ccggctccca gcgcgtccgg caacgactcc tcgcgctcgc cgcggacttc
    16201 actgccacgg ccgcttggtc aaccatcgac gcccgtcagc tcgaccgcgc agacagccgg
    16261 ctcaaagagg ccctgtacct ggcgcggatg gccgacgaca gcgccaccga gctgcgcgtg
    16321 tggaactcgc tggcgatgct cgcccatcag cgcaaggagc acggccaggc cgtcgatgcc
    16381 gggtacgcgg ctcaggccac gggcatcacc cgtcgcgatc cgttgttcgc gtcgctcgcc
    16441 cacgctcgga ccgcggtcgg gcacagcaac cgcggagacc ggcaggcggc gctgaggtca
    16501 ttcggcttcg ccgaggagat gctgagcaag gcggagccgg acaccgctcg gccaccgtgg
    16561 atcgcgttct acggccctgc cgagctgtac gccttgggcg cgatcgtccg ggaccggctc
    16621 ggtttcgcgg cagaggccga ggcatcctcg taccgtgcgc tggcagccct ccccaagcag
    16681 ttccgccgca accgcgccct ggccaccgca cggctcgcgc tggcgcagct acatcagggc
    16741 gaggccgaac aggcatgcga cacggcagcc tcgctcttcc agctgatggc cggcgctccc
    16801 ctgccggggc gcatgagatc gctgatgggc gacttccacc gcgaccttct caccctcgcg
    16861 ccggacgcga ccgtggcgcg cgagtggggc aaccgatacc gcgaccagtg gagccgaacg
    16921 tgaccgtcca gctgcgccag tacaaacacg acgaccttca cgagatccgc cagacgctca
    16981 tcgacgtcca cgccgatgcc tacgcggacc agatggacga cccgttcgta cagcgcttcc
    17041 cctggttcgt ggaccactgg ggcgggaacc ccggcttctc atgcctcatc ggctgggacg
    17101 ggagcgagcc cgctggcttc gcctacggcg cccccgcgac ggctggcagc gagtggtggc
    17161 gagaacacgt gaccgaagag cccgagaacc cgtcgacgtt ctcgctgtcc gagttgacgg
    17221 tgcggcccaa gtggcgcaag accggcgccg cagagcaact gcacgaggcg ctcctcgcca
    17281 gccgggacga ggcgctcgcc gtgctgctgg tcgacaccac ccatccgcgc gtgcaagccc
    17341 tgtacgagtc ctggcagtac cgcaaggtcg gcgagcggca gccgttcccc gactctcccg
    17401 tctatgcggt gatgctccgc tccctttcgc ccgcgctgag cagggtgtca accaccgacg
    17461 ggtgacggtg tcgcgtggca tgaccgcatt gccctgctcg tcacgcagat gcccaccgtg
    17521 cgggaggcta ccggcgggct gatcagcgcc ctccacggcg tgcggctgtg cggcccggtg
    17581 tccccggaac gcctccacat cgctccctca ccaactgaca cggccgacca gggtcggtct
    17641 ccgtcaaacg gcggtcgcgg ccggcgcgcc tcccggggac gcgccgccgc tacggcgtgg
    17701 cgaccgccgc ctgcggccgg atcgggaggc ggttgaccgg gcggccggtg gccgcgcgga
    17761 cggcggcggc gacggcggcc ggggaggtga cgaccgggac ggcgctggcc gccttcgcgc
    17821 cgaagggggc gaccacgtcg cgctcctcga cgagtctgac gatgcggatg tcgggggcgt
    17881 cgagggccgt cggcagggcg tagccggtca ggtcgggatg gcggaccaga ccgcgggccg
    17941 tgcggaggtt ctccgtgagc gcggcgccga tgccctgggt gacccccgcc tcgatccggg
    18001 tggcgagctg ggcggggttg aggacgcggc ccacgtcctg ggcgacggcc atctccacga
    18061 cgcgcacgga gccgagttcg acgtcgacgt cgacgaccgc gcggaccgcg cagaaggcga
    18121 gaccgacgaa ggcgtcgccc tggccgtggt cgtcgagggg ttcggtggga tgcggacggc
    18181 actgcgcggt ggcccagagc tccttgccgt ccatggcctc ggtgaccgtc gtggacagca
    18241 ctccgtcata cgaggtgatc ttgccgtcgt tgatctgcag cagttcggtg gacatgccga
    18301 acttgtgggc cagcggctgc agcagctgcg tacggaccat cttcgccgcg cgctcgacgg
    18361 caccgccgga gacccaggtg tggcgcccgt gggcggcggg gccggccgga ggctggtcgg
    18421 tgtcgacggg ggcgacgcgc acctcctcga tgccgagcgt ctcctgcacg atctgccggg
    18481 cgagggtgga gaagccctgc ccggtctcga cggccgcgca gatgaccgtg gccgtaccgt
    18541 cctggacctt caccgtggcc gtggagacct cgtcggtccc ctccgcaccg agcatgtgga
    18601 ccatgcccag ggcgtagccg acgccgcgcc gcaccgcacc gggctcgccc gcgccctctg
    18661 gtccgccggg cagcagccag gcgtcctccg gagtgtcctt gggcagcggc gggaggggga
    18721 agtcgcgtac ggcctggagc agttcggcca ccggggccgg gcaggtgacg gtctgcccgg
    18781 tggggaggat gtcgccggtg gcgaggacgt tgcggaggcg gatctcggcc gggtccagac
    18841 ccagcttcgc cgccagcttg tccatctggg cctcgtaggc ggcgcagacc tgaagcgcgc
    18901 cctctccgcg catatggccg gagggcgggt tgttggtgcg gaccgcccag ccctcgatga
    18961 aggcgtgcgg caccacgtac ggcccgcagg cgaaggcgac ggcggcggcg agggactccg
    19021 acgaggcgtc cgcgtaggcg cccgcgtcca gcaggatctg cgcctccacc ttcagcagcc
    19081 tgccctcggc gctcgcgtgg tggcggtagc ggagcagagt cgggtggcgg tgggcgtggc
    19141 cgaggaagga ctcctcgcgg gtggcggcga gcttgaccgg gcatccggtg cgcagggcga
    19201 gcagccccag cgggatctga aaccccgggt cctcccggtc gccggtcgcg ccgggcacac
    19261 cggtcacgac gaccttcacg cgctccttgt ccaggccgaa gcaggcggcg gcgaggtcgc
    19321 ggtcggtgtg cgggtcggtg gaggcggtgt agagctcgac cccgccgtcg gggcgcggca
    19381 cggcgaggcc ggcctcggcg ccgatgggtg ccgggtcctg gcggccgacg cggtagagcc
    19441 cttcgacgac gacctcgccg acggcctcgg ggtcgccgaa gctcagcggg atgtggcgga
    19501 tgaggttgcc gtcggggtgc agcggctcgg cggcgaaggc ctgctcgggg tcggtgaccg
    19561 gttcgaggac ctcgtactcg acggtgatcg cggcggcggc gagccgggcc gtgtcgggat
    19621 ggtcggcggc gaccgcggcg atggcctccc cgtggtggcg gacggtgtcg gaggcgaaga
    19681 cgggccggtc ggcgaccccg cgtccgtatg cggcgtcgcc gggtacgtcg gcgtgggtga
    19741 cgacggcccg gacgccgggc atcccggcgg cggcggaggt gtcgacggcg gtgatccggg
    19801 cgcgggggtg cggggagcgc aggatcgccg cccagagcag cccctcggcc cacaggtccg
    19861 aggcgtaggg gaaggtgccc tcggtcttgg cgcgggtgtc cgcctggggg agggcggcgc
    19921 cgaggccgtg agcgggcggt tcctgctcgg gaccgtcgac cgcgggggct gcgatggccg
    19981 cgtcgttgct cacaccatgc ctccgtcatg cgggtggggc tgcacactac cggcgcccgg
    20041 gggcgcctgg cgcgggatgc gggccgcgtc ctgggctgct tcgcggctcc cgtcggcggc
    20101 ctcggcggcc gcggcggcgc tcgccccgcg ttccgcggcc acctcgcgca cggcgtcgag
    20161 gacgccccgg tagccggagc agcggcagag gttgccggag agggcctggc gggtctcgag
    20221 ttccgtgggg gcgtggttgc cctccaacag gtcggacacg gtcatggcca tgcccgggat
    20281 gcagaatccg cactggactg ctccgcacgc ggccagcgcg cgctggacgt cggagggttc
    20341 gccgtcggcg gccaggccct cgacggtacg gacctcggag ccggccgcgg tcgccgcagg
    20401 caccaggcag gaggccacga gccggccgtc gacctggacg ttgcaggcgc cgcactcgcc
    20461 ctgcgagcag ccgtccttgg cgcccgcgag gccgaggcgc tcacgcagta catagagcag
    20521 ggactcgccg atccatgcgt cggtgacggg ccggtcggct ccgttcacgc gcaggacgta
    20581 cgaactgtgc gggtgttcgt cgttcgccgt cgccgtcgcc gtcgctgtgg tggcggaccc
    20641 gacaccctcc gcgccggccc cggacgtgtc gggagccgcc gcctccccgg ccgggggcgc
    20701 gtccggtggg tcctgacggg ctgggtcggg cgggtcctgg gaggccgcat cggcttccgg
    20761 gacctccacg gcccccccgg agacggcgtc cccggtgtcc ccggtgtccg cggtgtccgc
    20821 ggtgtcccca actccggtgt ccgcggtgtc gccggtgtcc ccggtgtccg cggcgcggcc
    20881 gggctccggg ctcgcgtcat gggcggtggt ccccggatga tcggcgtcgg cgcggtcggg
    20941 ctccgtgcgg tcgggctcgg tgccgtcgaa ctccgtacga tccagctccg tacggtccgc
    21001 ctctacgtgg ccggcctcca tgtgaccggc gtgaccggcc tccatgtcgc gggcctccac
    21061 gtggccggcc tccacgtggc cggcctccat gtgaccggcc tccatgtggc cggcctccat
    21121 gtgaccggcc tccatgtccc cggcccgcgg gcggtccgct tcggacggtt cgacgggata
    21181 cgacccgctc cggtccgggg cggcggcggc aggcgcaggc gcagcatcag cagacgcttc
    21241 gtcaccggca ccggggtgcg caccctcacc gtgcgggccg tgccccgctt cgtcgcgctg
    21301 ctcggtgcgg ggtccggcgg cggatccggc tcgctcctcc tgagcgggat acccctcggc
    21361 cgcccagggg gcgggtgcgc cgccgggcag ggtggcgggg tagccggctc cgggcaccgg
    21421 tgtgccggag gcgggcgtac cgccgagggg ggtgcccccg gccggggtgc cgccgtcggg
    21481 agtcgtggcc cacggagcgg gggcaccgcc gggcagggtg gccggcggag tacgaccgcc
    21541 ccactgcgcc agggcggatg ccgagaactc gcccgactcc tccgggaggt ccccgtgggc
    21601 gacgggaatg gtccactggc cggtgaggtc tctcgcgtcc gctgtcccgg cggggccgga
    21661 cgacggctcg tcagcctccg ggaaggtcca ctgacccgtc gcgtgcgggt cgtggccgtc
    21721 ggccgcgcca cggggcgcgc ggggatcgcc gccgccctcc gcgccgtggc cgccccggaa
    21781 accgccgccg ccgagcggag cggggccggg gtgcgcttcg tgcccggtgc ggggctcgcc
    21841 gtcaccctgc gggtcccggg caccccgagg gtcccgggca ccgtacggat ccggggcacc
    21901 gtacgcaccg tgcgggccgt agccaccgtg ctgttcaccg ccggcccgga ggtcgccgcc
    21961 ggcccgggag tccccgccgg cccggagacc ggagccgggg tacgcctggt gcgaggcgta
    22021 gggctgctgc ccggcatacg gctcgtaggg gttctgcggc tgcccggccc ccggagccgc
    22081 ccagtggtgc gaggcgtccg gcgcctgctc cgggacggtc cagcccgccg cccggccgtc
    22141 ctgtgccgcc ggtgggatct gcgggggcac atagccgtgg cccggcgcgg cgagcggtgc
    22201 gtcgcgcatg tcgtcggacg gcaggcggac gaacgcggtg gcctccgcgt cgtactcgcc
    22261 gccctgcggg atgggttgcc agccgccgcc gtgcggggcg gtgtcccggg gctcgttctc
    22321 ctcggagctc acgacagtgc cctccccagc gctcgtcggg ccagcgcggc gaccacgcgc
    22381 cgcaggtgca ggacggcggg cggcagctgc tcgtcgccct cctggtccgg gatgcaggcg
    22441 gccgccacgt actcgccgaa ggccgccagt gcctccgggg cgagtccgcg ctcagcgtcc
    22501 cagtcgatca gcgaggcgat ccagcgctcg gcctccagcg ggcgcagcgg catcggggcg
    22561 atcgcgccga ccgcgcagcg caccccgcgc cgtgccgggt cgaggacgac ggcgacggac
    22621 gccgtcgccc ggccggggcc ggtacgcccg gtggccttca ggaacacctg cggagcgtgc
    22681 aggagcggta cgcgcacgta gccgacgagt tcggcggggc cgagcagctc gcggccggcg
    22741 aggagatggg agacggggat ctcgcgtgtc actccgcccg gtcccgcgat caccaggtcc
    22801 gcttcgagag cggccagcac cggcagggtg tcgccggtgg gggcggaggt gacgatgttg
    22861 cccccgaggg tgcccgcgtt gcggatctgc gggggtccgg cggcgcgggc ggcggcggcg
    22921 agcgccggga tgagcgcggc gaagtcgggt cggcccatgc gggaatgggt gagtccggca
    22981 ccgagcaggg cgtggccgtc ctggtactgc cagccccgga tctcgttgat acggccgaga
    23041 ccgacgaggc ccgcgggcct gagccggccc ttgttgacgg ccgccatcag gtccgtgccc
    23101 ccggcgaccg gcacggcggc gggcatgtcg gtgagcgccg ccacggcctc tccgagcgag
    23161 gccggcagtg tcacggactg cgccgcttgc ggtgcgtgcg tggtcaaccc agctgcccct
    23221 tcccggtatc ccggctgtcc gtttgtgttg ccgtaccgta cgtcctcaca gtccggacgt
    23281 ggcaactctg gcacatcttc cgggcggtcc ggcgctgggg tccacgaagg acgcatccac
    23341 cccggacctc ccgtaacaag cggaatggcc gaattgccac ggcattaccg gcacgggcga
    23401 attgccggtt gaaggcattc cttgtacgac tttttcccac gggtgtccac gctcccaggg
    23461 agccggatcg ggaacagcct gttggggcag ggctcacacg tttgggggcg ccccctcgat
    23521 cgggcgtccg agcgcacccg cccgcctctc ccgcggtcgc ggacaccgcg cgggcggtgg
    23581 gcggacggcg cgcggacacc acgcggacac cgcacagacg gcgggtggcg ggcggacggc
    23641 gcgcggacac cgcgcagacg gcgggtggtg ggcggacggc gcgcggacac cgcgcagacg
    23701 gcgggcggcg gcgccggatg gggtcggcgc cggacgcggt cggccggggg gccggacacg
    23761 cgtcgcggcc tcccgcgatt gatcacgcga gaggccgcgg cccctgtccg ggggtcaagc
    23821 gcccttactt tccgccgtct tcggcgaggg tgtgcgcgac gagcgcgttg gcgtggccgt
    23881 gacccaaccc gtgctcggcc ttgagccagg agacgagttc cccgtggcgg gtcagaggcg
    23941 aggagcggat cagatccttc cactcggcta ccgggcggcc gtacttctgc tcgatcgagg
    24001 ggaagtagcc ggccgggccc ttcggttgtt cggtcatgct gacgtgttcc cgtccgttcg
    24061 cagtcggtgg ttccggattg ccgccccgcc gaagcgacgg gcgggaaagg ggggttggtg
    24121 ccgcctcacc ggcggtaccg ccgccatcag ccgggcggtg accgcggtga gccagaggag
    24181 g
//
