GCF_003116755.1 - 40 region(s)

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Location: 11,139 - 54,753 nt. (total: 43,615 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

DBP20_RS00065: methyltransferase

smcogs: SMCOG1248: methyltransferase

DBP20_RS00205: methyltransferase

smcogs: SMCOG1089: methyltransferase

Ligases: synthase

DBP20_RS00165: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001240.4	0.60	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001240.4	0.60	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 31.03 out of 36.53

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.65 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 26.66 out of 30.11

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 26.66 out of 30.11

Confidence: medium

Additional weak hits (8):

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.00 out of 32.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.80 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.09 out of 31.73

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.94 out of 25.88

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.08 out of 28.19

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.85 out of 20.01

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.62 out of 28.19

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.96 out of 27.04

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 11138 - 54753:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS00165: X

AMP-binding (23..420): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: MSMAFDPSVMEGIMVLGGEVNVYGPTEATVFVTA
Nearest Stachelhaus code(s):: Val DAMFVGGVFK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor
DmdR1	Iron(II)-dependent repressor

NZ_KZ819178.1 - Region 2 - butyrolactone

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Location: 72,268 - 83,212 nt. (total: 10,945 nt) Show pHMM detection rules used

butyrolactone: AfsA

Legend:

core biosynthetic genes

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other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DBP20_RS00325: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

DBP20_RS00360: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.86	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.83	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.49	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001633.3	0.41	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001364.3	0.40	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000194.5	0.38	PKS	actinorhodin	Streptomyces coelicolor A3(2)
BGC0001858.2	0.38	PKS	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.3	0.36	PKS	oronofacic acid	Pseudomonas syringae
BGC0001964.2	0.35	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.86	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.83	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.49	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001633.3	0.41	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001364.3	0.40	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000194.5	0.38	PKS	actinorhodin	Streptomyces coelicolor A3(2)
BGC0001858.2	0.38	PKS	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.3	0.36	PKS	oronofacic acid	Pseudomonas syringae
BGC0001964.2	0.35	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (2):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.99 out of 26.85

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.27 out of 28.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 3 - terpene

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Location: 109,037 - 131,250 nt. (total: 22,214 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase hydratase

DBP20_RS00580: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

DBP20_RS00615: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase

DBP20_RS00620: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.83	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3	0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486
BGC0000658.3	0.56	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001135.5	0.56	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.55	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.55	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.55	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.55	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.83	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3	0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486
BGC0000658.3	0.56	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001135.5	0.56	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.55	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.55	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.55	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.55	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene		germacradienol	C15	C1-C10	OH
sesquiterpene		geosmin	C12	C1-C10	OH

Genes with terpene domains:

DBP20_RS00580: T1TS + T1TS

Domain 1 (2 - 326): Type 1 terpene synthase

Subtype: Geosmin synthase, N terminal domain

Reactions:: FPP → germacradienol

Domain 2 (336 - 697): Type 1 terpene synthase

Subtype: Geosmin synthase, C terminal domain

Reactions:: germacradienol → geosmin

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (12):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.80 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.58 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.35 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.21 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.75 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.71 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.75 out of 27.78

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.32 out of 30.22

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.37 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.20 out of 29.65

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.27 out of 33.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 4 - NRP-metallophore,NRPS

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Location: 165,718 - 264,268 nt. (total: 98,551 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

DBP20_RS00890: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS00925: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

DBP20_RS01025: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

DBP20_RS01125: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS01130: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Hydrolases: esterase hydrolase

DBP20_RS00860: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

DBP20_RS00880: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

DBP20_RS00905: isochorismatase

smcogs: SMCOG1027: isochorismatase

DBP20_RS00985: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

Lyases: dehydratase

DBP20_RS01030: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: isomerase

DBP20_RS00895: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

DBP20_RS00865: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS00900: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS00995: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS01045: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000368.5	1.27	NRPS	griseobactin	Streptomyces sp. ATCC 700974
BGC0001825.4	1.04	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.98	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.97	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001128.4	0.97	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.95	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000325.5	0.89	NRPS	coelichelin	Streptomyces coelicolor A3(2)
BGC0000307.4	0.87	NRPS	AbT1	Aureobasidium pullulans
BGC0000401.5	0.80	NRPS	paenibactin	Paenibacillus elgii B69
BGC0000343.5	0.77	NRPS	enterobactin	Pseudomonas sp. J465

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000368.5	0.83	NRPS	griseobactin	Streptomyces sp. ATCC 700974
BGC0000343.5	0.71	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000325.5	0.69	NRPS	coelichelin	Streptomyces coelicolor A3(2)
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000401.5	0.68	NRPS	paenibactin	Paenibacillus elgii B69
BGC0001758.4	0.68	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.67	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.44 out of 23.79

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.74 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.57 out of 36.53

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.25 out of 29.72

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.86 out of 27.04

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.94 out of 27.04

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.92 out of 26.85

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 30.19 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.88 out of 36.53

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.88 out of 29.72

Confidence: medium

Additional weak hits (32):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 17.81 out of 25.88

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.10 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.73 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.51 out of 30.22

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.07 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.28 out of 21.55

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.60 out of 39.62

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.46 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.77 out of 29.38

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.65 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.48 out of 29.38

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.89 out of 27.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.19 out of 29.65

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.57 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.10 out of 29.65

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.02 out of 35.63

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.32 out of 33.14

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.71 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.24 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.40 out of 36.53

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.87 out of 20.01

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.07 out of 30.98

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.54 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.81 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.19 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.99 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.38 out of 26.06

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 165717 - 264268:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Fo-OH-Orn - D-Thr - OH-Orn) + (Arg - Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS00865: Arg - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (546..960): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LGHAFDASWDPWDVVVGGEVNLYGPTETTVDAYY
Nearest Stachelhaus code(s):: Arg DADDVGLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1638..2046): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

DBP20_RS00900: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (32..439): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SGSLFPLSSPGGGLLVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPGLGVVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

DBP20_RS00995: Fo-OH-Orn - Thr - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (144..542): Fo-OH-Orn

nrpys: Fo-OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: RWQAFDISVNELYLWCGGEYHGYGPAETTIGVSH
Nearest Stachelhaus code(s):: Fo-OH-Orn DINYWGGIGK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1626..2039): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNTHFDFAVWEGNQVFGGEVNMYGITETTVHVTH
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3090..3488): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: MNHVFDMSWEEWNVLLGGEYNLYGPTEYTINTLG
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism
NtrC	Nitrogen regulatory protein C
RutR	Regulator of the pyrimidine and purine metabolism

NZ_KZ819178.1 - Region 5 - T3PKS

Download region SVG

Location: 298,311 - 339,444 nt. (total: 41,134 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

DBP20_RS01340: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

DBP20_RS01415: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: kinase

DBP20_RS01355: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: glucosidase protease

DBP20_RS01405: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

DBP20_RS01465: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: synthase

DBP20_RS01330: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS01345: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS01350: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

DBP20_RS01410: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001310.5	0.83	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.71	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.67	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.61	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0001254.3	0.55	PKS	ACT-Toxin II	Alternaria alternata
BGC0000280.5	0.53	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002711.2	0.52	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000281.3	0.52	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002285.2	0.52	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002476.2	0.51	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001310.5	0.83	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.71	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.67	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.61	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0001254.3	0.55	PKS	ACT-Toxin II	Alternaria alternata
BGC0000280.5	0.53	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002711.2	0.52	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000281.3	0.52	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002285.2	0.52	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002476.2	0.51	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.21 out of 27.78

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.62 out of 36.53

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.62 out of 25.88

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.63 out of 18.46

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (11):

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.80 out of 19.26

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.74 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.31 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.99 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.30 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.92 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.66 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.16 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.33 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.82 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.09 out of 28.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
DmdR1	Iron(II)-dependent repressor
PsrA	Oleic acid responsive regulator
RpoN	Regulator of nitrogen assimilation and virulence

NZ_KZ819178.1 - Region 6 - NRPS-like

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Location: 605,913 - 648,732 nt. (total: 42,820 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

DBP20_RS02725: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: aminotransferase methyltransferase

DBP20_RS02715: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

DBP20_RS02720: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase protease

DBP20_RS02620: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

DBP20_RS02650: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: ligase

DBP20_RS02680: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS02685: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS02690: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.67	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.67	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.70 out of 23.79

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.60 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.36 out of 28.19

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.00 out of 28.19

Confidence: medium

Additional weak hits (12):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.19 out of 26.85

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 36.53

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.94 out of 25.88

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.09 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.24 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.41 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.24 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.93 out of 29.38

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.19 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.28 out of 29.65

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.12 out of 28.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.35 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 6, location 605912 - 648732:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS02680: X

AMP-binding (17..367): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ERHNHNMGVSGHYGVSGGECPVYGVTEIGLIAGD
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

DBP20_RS02695: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (2..379): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDPSFDASTYETWLWTGGEIDGYGPTETTTFATH
Nearest Stachelhaus code(s):: Val DAYWWGGTFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA	Catabolite control protein A
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

NZ_KZ819178.1 - Region 7 - terpene

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Location: 693,323 - 721,321 nt. (total: 27,999 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DBP20_RS03090: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: glycosyltransferase

DBP20_RS03070: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

DBP20_RS03075: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase

DBP20_RS03060: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: synthetase

DBP20_RS03085: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.74	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.69	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.67	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.64	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.64	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.55	terpene	carotenoid	Myxococcus xanthus
BGC0000646.5	0.51	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.50	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000645.3	0.49	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000641.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.74	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.69	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.67	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.64	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.64	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.55	terpene	carotenoid	Myxococcus xanthus
BGC0000646.5	0.51	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.50	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000645.3	0.49	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000641.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

DBP20_RS03085: PT_FPPS_like

Domain 1 (29 - 329): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

DBP20_RS03095: PT_phytoene_like

Domain 1 (16 - 312): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → PSPP; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

DBP20_RS35920: Lycopene_cycl

Domain 1 (23 - 268): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

DBP20_RS35925: Lycopene_cycl

Domain 1 (29 - 190): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (14):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.27 out of 20.97

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.20 out of 30.22

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.77 out of 32.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.05 out of 31.73

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.72 out of 32.93

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.24 out of 32.38

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 24.31 out of 32.93

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 23.65 out of 32.38

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.56 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.22 out of 32.74

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.62 out of 26.85

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 25.75

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.65 out of 35.63

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description

NZ_KZ819178.1 - Region 8 - NRPS,NRPS-like

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Location: 904,591 - 964,778 nt. (total: 60,188 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

DBP20_RS04040: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

DBP20_RS04070: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS04075: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS04155: Dioxygenase TauD/TfdA

smcogs: SMCOG1046: Dioxygenase TauD/TfdA

DBP20_RS04185: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase methyltransferase

DBP20_RS04150: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

DBP20_RS04235: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase hydrolase

DBP20_RS04135: thioesterase

smcogs: SMCOG1004: thioesterase

DBP20_RS04205: putative esterase

smcogs: SMCOG1104: putative esterase

DBP20_RS04215: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: ligase synthetase

DBP20_RS04095: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

DBP20_RS04120: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS04165: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS36375: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.83	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.79	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.78	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.78	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.77	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.77	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000342.4	0.72	NRPS	enniatin	Fusarium equiseti
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.16 out of 23.43

Confidence: medium

Additional weak hits (21):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.57 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.35 out of 30.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.81 out of 33.14

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.32 out of 30.98

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.97 out of 35.63

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.65 out of 22.40

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.26 out of 27.18

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.24 out of 26.85

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.26 out of 23.43

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.32 out of 30.22

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.45 out of 18.57

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.33 out of 30.97

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.39 out of 25.88

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.47 out of 28.19

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.73 out of 24.78

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 25.75

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.70 out of 35.63

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.11 out of 26.85

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.70 out of 33.14

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.63 out of 24.78

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 8, location 904590 - 964778:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Asp - X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 904590 - 958608:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Asp - X) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 10, location 922954 - 964778:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Asp - X) + (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS04120: X

AMP-binding (459..842): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: WGMAFDVMSAEMMGVLGGDGQVYGASEGSISSTI
Nearest Stachelhaus code(s):: Arg DVENVGVISK (53% 8Å match)
Stachelhaus code match:: 80% (moderate)

DBP20_RS36375: Asp - X

Search NORINE for peptide: strict or relaxed

AMP-binding (299..684): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: ADLAFDASWRAGSCLAGGEFNLYGPTECTVDVTV
Nearest Stachelhaus code(s):: Arg DAWSFGLVDK (50% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1348..1749): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LAFSFDSAVK-LSCLIGGEYNLYGPTECTVDATV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (68% 8Å match); Asp DSWKLGVVDK (50% 8Å match)
Stachelhaus code match:: 70% (weak)

DBP20_RS04165: X

AMP-binding (11..415): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LAVGWDSSIEELYLLIGGEWNCYGLTETCVTSTI
Nearest Stachelhaus code(s):: Orn DSEDLGFVDK (41% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A

NZ_KZ819178.1 - Region 9 - terpene

Download region SVG

Location: 1,073,832 - 1,094,908 nt. (total: 21,077 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DBP20_RS04750: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: formyltransferase

DBP20_RS04780: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Lyases: cyclase hydratase

DBP20_RS04730: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

DBP20_RS04760: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002708.2	0.75	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0002707.2	0.47	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000631.5	0.37	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10
BGC0002034.3	0.36	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000879.5	0.35	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001677.3	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0002616.2	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0001360.3	0.34	PKS	mycophenolic acid	Penicillium roqueforti FM164
BGC0002619.2	0.34	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0000881.3	0.33	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002708.2	0.75	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0002707.2	0.47	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000631.5	0.37	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10
BGC0002034.3	0.36	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000879.5	0.35	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001677.3	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0002616.2	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0001360.3	0.34	PKS	mycophenolic acid	Penicillium roqueforti FM164
BGC0002619.2	0.34	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0000881.3	0.33	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
monoterpene			C10	C1-C10	none
sesquiterpene			C15	C1-C10	none

Genes with terpene domains:

DBP20_RS04760: T1TS

Domain 1 (4 - 315): Type 1 terpene synthase

Subtype: Germacrene A synthase type

Reactions:: GPP → monoterpene_C1-C10; FPP → sesquiterpene_C1-C10

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (14):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.49 out of 39.62

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.23 out of 20.97

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.15 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.76 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.18 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.70 out of 26.06

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.37 out of 26.12

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.43 out of 39.62

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.00 out of 35.63

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.87 out of 32.93

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.10 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.72 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GPP	Geranyl diphoshate

TFBS definitions

Regulator	Description

NZ_KZ819178.1 - Region 10 - ectoine

Download region SVG

Location: 1,524,066 - 1,534,464 nt. (total: 10,399 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

DBP20_RS06830: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

DBP20_RS06840: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

DBP20_RS06870: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.91	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.59	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.91	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.59	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52

Confidence: medium

Additional weak hits (11):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.02 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.98 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.13 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.35 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.70 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.75 out of 21.55

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.50 out of 26.12

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.51 out of 27.78

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.76 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.36 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_KZ819178.1 - Region 11 - lanthipeptide-class-ii,lanthipeptide-class-iii

Download region SVG

Location: 2,486,728 - 2,517,904 nt. (total: 31,177 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

DBP20_RS11200: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Hydrolases: protease

DBP20_RS11260: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

DBP20_RS11210: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Translocases: transport

DBP20_RS11180: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.37	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000525.5	0.36	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001226.4	0.36	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000519.4	0.36	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000501.3	0.35	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000518.3	0.35	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000554.4	0.34	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002704.2	0.32	ribosomal	archalan β	Halorussus salinus
BGC0000513.3	0.32	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000517.4	0.29	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.50	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001226.4	0.49	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000519.4	0.49	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000501.3	0.49	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000518.3	0.49	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus
BGC0000513.3	0.47	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001407.5	0.45	ribosomal	bicereucin	Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for DBP20_RS11210

DBP20_RS35630

Leader:

MSENTKPAADETNETPEVEAHSVLDLQETSVQGG

DBP20_RS35630

Leader:

MSENTKPAADETNETPEVEAHSVLDLQETSVQGG

Shared core:

DTTDGNCISVLSVVEQQR

Core with dehydrations:

DDhbDhbDGNCysIDhaVLDhaVVEQQR

antiSMASH-DB 4.0 matches for DBP20_RS35630

100.0%

NZ_BMRY01000010.1and 58 others:

NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide

Lanthipeptides: IE140_RS27680_lanthipeptide

1

DTTDGNCISVLSVVEQQR

18

DTTDGNCISVLSVVEQQR

1

DTTDGNCISVLSVVEQQR

18

94.4%

NZ_BNBJ01000007.1and 21 others:

NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide

Lanthipeptides: IE304_RS13825_lanthipeptide

1

DTTDGNCISVLSVVEQQR

18

DTTDGNCISVLSVVE QR

1

DTTDGNCISVLSVVESQR

18

78.9%

NZ_CP117709.1:

Lanthipeptides: PSQ21_RS10520_lanthipeptide

1

DTTDGNCISVLSVVEQQ

17

D TDGNCISVLSVVE Q

1

DQTDGNCISVLSVVETQ

17

with 13 more sequence matches

Only the first 10 are displayed here.

72.2%

Lanthipeptides: A3Q37_RS37410_lanthipeptide

5

GNCISVLSVVEQQR

18

GNCISVLSVVE QR

1

GNCISVLSVVESQR

14

61.1%

NZ_BNBJ01000007.1and 7 others:

NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide

Lanthipeptides: IE304_RS13830_lanthipeptide

5

GNCISVLSVVEQ

16

GNCISVLSVVE

2

GNCISVLSVVEN

13

57.9%

Lanthipeptides: A3Q37_RS37415_lanthipeptide

2

TTDGNCISVLSVVEQ

16

GNCISVLSVVE

5

APPGNCISVLSVVEN

19

50.0%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide

Lanthipeptides: ASD51_RS37395_lanthipeptide

7

CISVLSVVE

15

CISVLSVVE

1

CISVLSVVE

9

38.9%

NZ_CP119145.1:

Lanthipeptides: PZB75_RS01650_lanthipeptide

7

CISVLSVVEQQR

18

C+SV+SVV +R

1

CVSVISVVLSER

12

33.3%

NZ_ML142907.1and 1 other:

NZ_ML142907.1 Lanthipeptides: DN53_RS02460_lanthipeptide

Lanthipeptides: DN53_RS02460_lanthipeptide

1

DTTDGNCISVLSVV

14

DTT+G+C S S+V

7

DTTNGDCTSGTSIV

20

23.5%

NC_021177.1and 9 others:

NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide

Lanthipeptides: SFUL_RS36595_lanthipeptide

5

GNCISVLSVV

14

G+C+SVLSVV

22

GSCVSVLSVV

31

22.2%

NZ_CP058552.1:

Lanthipeptides: HW560_RS06640_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+S ++

7

TDGNCVSTITA

17

20.0%

NZ_BDHJ01000009.1and 1 other:

NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide

Lanthipeptides: BHQ08_RS34920_lanthipeptide

5

GNCISVLSVV

14

GNC+S +S+V

19

GNCVSTVSLV

28

19.2%

NZ_BMLN01000009.1:

Lanthipeptides: IEX28_RS15335_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+ ++

7

TDGNCLKSITA

17

allorf_2503102_2503281

Leader:

MRAYGHGGPGRPTWGCRAVSVGYPGGKCGRDPDVRGS

allorf_2503102_2503281

Leader:

MRAYGHGGPGRPTWGCRAVSVGYPGGKCGRDPDVRGS

Shared core:

GRQQDRPCVRSSPPPVPLPEAR

Core with dehydrations:

GRQQDRPCysVRDhaDhaPPPVPLPEAR

antiSMASH-DB 4.0 matches for allorf_2503102_2503281

100.0%

NZ_BMRY01000010.1and 15 others:

NZ_BMRY01000010.1 Lanthipeptides: allorf_180163_180342_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: allorf_180163_180342_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_1494754_1494933_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_1494754_1494933_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_1494754_1494933_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_1494754_1494933_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: allorf_034471_034650_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: allorf_034471_034650_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: allorf_034471_034650_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_2503102_2503281_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_2503102_2503281_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_2503102_2503281_lanthipeptideNZ_KZ819182.1 Lanthipeptides: allorf_2583361_2583540_lanthipeptideNZ_KZ819182.1 Lanthipeptides: allorf_2583361_2583540_lanthipeptideNZ_KZ819182.1 Lanthipeptides: allorf_2583361_2583540_lanthipeptide

Lanthipeptides: allorf_180163_180342_lanthipeptide

1

GRQQDRPCVRSSPPPVPLPEAR

22

GRQQDRPCVRSSPPPVPLPEAR

1

GRQQDRPCVRSSPPPVPLPEAR

22

86.4%

NZ_CP029361.1and 6 others:

NZ_CP029361.1 Lanthipeptides: allorf_5008231_5008416_lanthipeptideNZ_CP029361.1 Lanthipeptides: allorf_5008231_5008416_lanthipeptideNZ_CP029361.1 Lanthipeptides: allorf_5008231_5008416_lanthipeptideNZ_CP090837.1 Lanthipeptides: allorf_2610704_2610889_lanthipeptideNZ_CP090837.1 Lanthipeptides: allorf_2610704_2610889_lanthipeptideNZ_CP090837.1 Lanthipeptides: allorf_2610704_2610889_lanthipeptide

Lanthipeptides: allorf_5008231_5008416_lanthipeptide

3

QQDRPCVRSSPPPVPLPEAR

22

QQDR CVRSSPPPVPLPEAR

3

QQDRTCVRSSPPPVPLPEAR

22

58.3%

NZ_JAJUKK010000002.1and 7 others:

NZ_JAJUKK010000002.1 Lanthipeptides: allorf_0338951_0339136_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: allorf_0338951_0339136_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: allorf_0338951_0339136_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: allorf_353255_353434_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: allorf_353255_353434_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: allorf_353255_353434_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: allorf_353255_353434_lanthipeptide

Lanthipeptides: allorf_0338951_0339136_lanthipeptide

1

GRQQDRPCVRSSPPPVPLPEAR

22

GRQQDR CVRSSPPPVPLPEAR

15

GRQQDRTCVRSSPPPVPLPEAR

36

with 1 more sequence matches

18.2%

NZ_CP014228.1:

Lanthipeptides: allorf_2802472_2802663_lanthipeptide

1

GRQQDRPCVRSS

12

GR ++RPC R

5

GRYEERPCERHQ

16

Lanthipeptide(s) for DBP20_RS11230

DBP20_RS35630

Leader:

MSENTKPAADETNETPEVEAHSVLDLQETSVQGG

DBP20_RS35630

Leader:

MSENTKPAADETNETPEVEAHSVLDLQETSVQGG

Shared core:

DTTDGNCISVLSVVEQQR

Core with dehydrations:

DDhbDhbDGNCysIDhaVLDhaVVEQQR

antiSMASH-DB 4.0 matches for DBP20_RS35630

100.0%

NZ_BMRY01000010.1and 58 others:

NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide

Lanthipeptides: IE140_RS27680_lanthipeptide

1

DTTDGNCISVLSVVEQQR

18

DTTDGNCISVLSVVEQQR

1

DTTDGNCISVLSVVEQQR

18

94.4%

NZ_BNBJ01000007.1and 21 others:

NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide

Lanthipeptides: IE304_RS13825_lanthipeptide

1

DTTDGNCISVLSVVEQQR

18

DTTDGNCISVLSVVE QR

1

DTTDGNCISVLSVVESQR

18

78.9%

NZ_CP117709.1:

Lanthipeptides: PSQ21_RS10520_lanthipeptide

1

DTTDGNCISVLSVVEQQ

17

D TDGNCISVLSVVE Q

1

DQTDGNCISVLSVVETQ

17

with 13 more sequence matches

Only the first 10 are displayed here.

72.2%

Lanthipeptides: A3Q37_RS37410_lanthipeptide

5

GNCISVLSVVEQQR

18

GNCISVLSVVE QR

1

GNCISVLSVVESQR

14

61.1%

NZ_BNBJ01000007.1and 7 others:

NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide

Lanthipeptides: IE304_RS13830_lanthipeptide

5

GNCISVLSVVEQ

16

GNCISVLSVVE

2

GNCISVLSVVEN

13

57.9%

Lanthipeptides: A3Q37_RS37415_lanthipeptide

2

TTDGNCISVLSVVEQ

16

GNCISVLSVVE

5

APPGNCISVLSVVEN

19

50.0%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide

Lanthipeptides: ASD51_RS37395_lanthipeptide

7

CISVLSVVE

15

CISVLSVVE

1

CISVLSVVE

9

38.9%

NZ_CP119145.1:

Lanthipeptides: PZB75_RS01650_lanthipeptide

7

CISVLSVVEQQR

18

C+SV+SVV +R

1

CVSVISVVLSER

12

33.3%

NZ_ML142907.1and 1 other:

NZ_ML142907.1 Lanthipeptides: DN53_RS02460_lanthipeptide

Lanthipeptides: DN53_RS02460_lanthipeptide

1

DTTDGNCISVLSVV

14

DTT+G+C S S+V

7

DTTNGDCTSGTSIV

20

23.5%

NC_021177.1and 9 others:

NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide

Lanthipeptides: SFUL_RS36595_lanthipeptide

5

GNCISVLSVV

14

G+C+SVLSVV

22

GSCVSVLSVV

31

22.2%

NZ_CP058552.1:

Lanthipeptides: HW560_RS06640_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+S ++

7

TDGNCVSTITA

17

20.0%

NZ_BDHJ01000009.1and 1 other:

NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide

Lanthipeptides: BHQ08_RS34920_lanthipeptide

5

GNCISVLSVV

14

GNC+S +S+V

19

GNCVSTVSLV

28

19.2%

NZ_BMLN01000009.1:

Lanthipeptides: IEX28_RS15335_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+ ++

7

TDGNCLKSITA

17

allorf_2503102_2503281

Leader:

MRAYGHGGPGRPTWGCRAVSVGYPGGKCGRDPDVRGS

allorf_2503102_2503281

Leader:

MRAYGHGGPGRPTWGCRAVSVGYPGGKCGRDPDVRGS

Shared core:

GRQQDRPCVRSSPPPVPLPEAR

Core with dehydrations:

GRQQDRPCysVRDhaDhaPPPVPLPEAR

antiSMASH-DB 4.0 matches for allorf_2503102_2503281

100.0%

NZ_BMRY01000010.1and 15 others:

NZ_BMRY01000010.1 Lanthipeptides: allorf_180163_180342_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: allorf_180163_180342_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_1494754_1494933_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_1494754_1494933_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_1494754_1494933_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_1494754_1494933_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: allorf_034471_034650_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: allorf_034471_034650_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: allorf_034471_034650_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_2503102_2503281_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_2503102_2503281_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_2503102_2503281_lanthipeptideNZ_KZ819182.1 Lanthipeptides: allorf_2583361_2583540_lanthipeptideNZ_KZ819182.1 Lanthipeptides: allorf_2583361_2583540_lanthipeptideNZ_KZ819182.1 Lanthipeptides: allorf_2583361_2583540_lanthipeptide

Lanthipeptides: allorf_180163_180342_lanthipeptide

1

GRQQDRPCVRSSPPPVPLPEAR

22

GRQQDRPCVRSSPPPVPLPEAR

1

GRQQDRPCVRSSPPPVPLPEAR

22

86.4%

NZ_CP029361.1and 6 others:

NZ_CP029361.1 Lanthipeptides: allorf_5008231_5008416_lanthipeptideNZ_CP029361.1 Lanthipeptides: allorf_5008231_5008416_lanthipeptideNZ_CP029361.1 Lanthipeptides: allorf_5008231_5008416_lanthipeptideNZ_CP090837.1 Lanthipeptides: allorf_2610704_2610889_lanthipeptideNZ_CP090837.1 Lanthipeptides: allorf_2610704_2610889_lanthipeptideNZ_CP090837.1 Lanthipeptides: allorf_2610704_2610889_lanthipeptide

Lanthipeptides: allorf_5008231_5008416_lanthipeptide

3

QQDRPCVRSSPPPVPLPEAR

22

QQDR CVRSSPPPVPLPEAR

3

QQDRTCVRSSPPPVPLPEAR

22

58.3%

NZ_JAJUKK010000002.1and 7 others:

NZ_JAJUKK010000002.1 Lanthipeptides: allorf_0338951_0339136_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: allorf_0338951_0339136_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: allorf_0338951_0339136_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: allorf_353255_353434_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: allorf_353255_353434_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: allorf_353255_353434_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: allorf_353255_353434_lanthipeptide

Lanthipeptides: allorf_0338951_0339136_lanthipeptide

1

GRQQDRPCVRSSPPPVPLPEAR

22

GRQQDR CVRSSPPPVPLPEAR

15

GRQQDRTCVRSSPPPVPLPEAR

36

with 1 more sequence matches

18.2%

NZ_CP014228.1:

Lanthipeptides: allorf_2802472_2802663_lanthipeptide

1

GRQQDRPCVRSS

12

GR ++RPC R

5

GRYEERPCERHQ

16

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

Additional weak hits (7):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.75 out of 39.62

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.83 out of 20.97

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.96 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.44 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 16.93 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.76 out of 36.54

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.80 out of 28.19

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

DBP20_RS35630 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1890.9 Da

Molecular weight: 1892.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1910.1 Da N = 1; 1928.1 Da N = 2; 1946.1 Da N = 3

allorf_2503102_2503281 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 2405.3 Da

Molecular weight: 2406.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2424.7 Da N = 1

DBP20_RS35630 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1890.9 Da

Molecular weight: 1892.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1910.1 Da N = 1; 1928.1 Da N = 2; 1946.1 Da N = 3

allorf_2503102_2503281 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 2405.3 Da

Molecular weight: 2406.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2424.7 Da N = 1

DBP20_RS35630 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1890.9 Da

Molecular weight: 1892.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1910.1 Da N = 1; 1928.1 Da N = 2; 1946.1 Da N = 3

allorf_2503102_2503281 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 2405.3 Da

Molecular weight: 2406.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2424.7 Da N = 1

DBP20_RS35630 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1890.9 Da

Molecular weight: 1892.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1910.1 Da N = 1; 1928.1 Da N = 2; 1946.1 Da N = 3

allorf_2503102_2503281 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 2405.3 Da

Molecular weight: 2406.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2424.7 Da N = 1

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_KZ819178.1 - Region 12 - NI-siderophore

Download region SVG

Location: 2,569,928 - 2,599,706 nt. (total: 29,779 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

DBP20_RS11560: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Hydrolases: hydrolase

DBP20_RS11585: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: decarboxylase

DBP20_RS11555: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Translocases: transporter

DBP20_RS11635: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000941.3	0.88	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.78	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000940.5	0.71	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.71	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.62	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002690.2	0.59	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000941.3	0.88	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.78	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000940.5	0.71	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.71	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.62	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002690.2	0.59	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.14 out of 23.79

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.29 out of 27.55

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 35.53 out of 36.53

Confidence: strong

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.04 out of 27.04

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 30.11 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 30.11 out of 30.11

Confidence: strong

Additional weak hits (10):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.13 out of 30.97

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.45 out of 36.53

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.25 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.29 out of 36.54

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.31 out of 31.73

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.13 out of 24.78

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.23 out of 23.43

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.83 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.10 out of 30.11

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor
DasR	N-acetylglucosamine dependent repressor
DmdR1	Iron(II)-dependent repressor
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism

NZ_KZ819178.1 - Region 13 - RRE-containing,azole-containing-RiPP

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Location: 2,965,782 - 3,000,596 nt. (total: 34,815 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

DBP20_RS13350: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Lyases: dehydratase

DBP20_RS13385: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001145.5	0.40	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001146.5	0.37	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000603.5	0.36	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001472.5	0.34	ribosomal	berninamycin A	Streptomyces bernensis
BGC0001640.3	0.33	ribosomal	kocurin	Kocuria rosea
BGC0000607.5	0.32	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0002316.2	0.31	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000569.5	0.31	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001860.4	0.30	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000566.5	0.29	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001145.5	0.53	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5	0.51	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001146.5	0.50	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001860.4	0.50	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0001640.3	0.49	ribosomal	kocurin	Kocuria rosea
BGC0001472.5	0.48	ribosomal	berninamycin A	Streptomyces bernensis
BGC0000607.5	0.47	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001174.4	0.47	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000613.5	0.47	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0000569.5	0.47	ribosomal	plantazolicin	Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.68 out of 20.47

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.32 out of 23.79

Confidence: medium

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Thiopeptide_F_RRE; Location: 39 - 118; Score: 62.5; RRE type: Heterocycloanthracin_C_RRE; Location: 39 - 122; Score: 40.2
: RRE type: Thiopeptide_F_RRE; Location: 39 - 118; Score: 62.5; RRE type: Heterocycloanthracin_C_RRE; Location: 39 - 122; Score: 40.2

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

Core peptide predictions

No core peptides found.

NZ_KZ819178.1 - Region 14 - NRPS-like

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Location: 3,080,261 - 3,122,033 nt. (total: 41,773 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

DBP20_RS13885: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS13920: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DBP20_RS13945: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

DBP20_RS13975: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase methyltransferase

DBP20_RS13870: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

DBP20_RS13935: methyltransferase

smcogs: SMCOG1089: methyltransferase

DBP20_RS14005: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: dehalogenase esterase hydrolase

DBP20_RS13825: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

DBP20_RS13890: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

DBP20_RS13925: thioesterase

smcogs: SMCOG1004: thioesterase

DBP20_RS13980: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase

DBP20_RS13930: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transport

DBP20_RS13950: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.64	NRPS	peramine	Epichloe festucae
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3	0.61	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002174.2	0.60	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.64	NRPS	peramine	Epichloe festucae
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002075.3	0.61	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002174.2	0.60	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 21.29 out of 23.43

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.52 out of 23.79

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 25.37 out of 30.12

Confidence: medium

Additional weak hits (10):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.73 out of 29.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.40 out of 23.43

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.91 out of 32.74

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.74 out of 30.25

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.97 out of 36.54

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.47 out of 30.98

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.56 out of 33.14

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.71 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 18, location 3080260 - 3122033:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS13930: X

AMP-binding (22..404): X

nrpys: 6-clTrp, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LNAVFDGWLWSTCMVVAGEINVYGPTETTIAATM
Nearest Stachelhaus code(s):: 6-clTrp or Trp DGWCVAVIAK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
IolR	Regulator of the inositol catabolism
OsdR	Development and stress management regulator

NZ_KZ819178.1 - Region 15 - NRPS

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Location: 3,258,903 - 3,313,459 nt. (total: 54,557 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DBP20_RS14705: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase aminotransferase

DBP20_RS14700: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

DBP20_RS14855: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: esterase hydrolase

DBP20_RS14665: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

DBP20_RS14845: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

Isomerases: mutase

DBP20_RS14850: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: ligase

DBP20_RS14695: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS14735: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS14750: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS14755: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS14760: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS14765: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001250.4	0.69	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.69	NRPS	epichloenin A	Epichloe festucae
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001250.4	0.69	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.69	NRPS	epichloenin A	Epichloe festucae
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.26 out of 27.04

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.73 out of 36.53

Confidence: medium

Additional weak hits (8):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.22 out of 20.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.89 out of 30.97

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.85 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.41 out of 31.73

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.46 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.88 out of 39.62

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.70 out of 26.33

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 19, location 3258902 - 3313459:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Lys) + (Ser) + (Gly)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS14695: X

AMP-binding (54..509): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TATAFDRAAR-I--ICGGSFEGYGLTETTAAHTV
Nearest Stachelhaus code(s):: nDodec DVLFIGGVAK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

DBP20_RS14750: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (456..844): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: LSLTFDISTVELQALAGGEFNVYGPTETTVWSTL
Nearest Stachelhaus code(s):: Gly DILQLGVVWK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

DBP20_RS14755: X

AMP-binding (54..502): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GSDFTNAGQTMNFLGSTAAVNYYTSTEAAPAQIT
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

DBP20_RS14760: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (563..955): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFVCSGEANLYGPTEAAVDVTS
Nearest Stachelhaus code(s):: Ser DVWHVSLVDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

DBP20_RS14765: Lys

Search NORINE for peptide: strict or relaxed

AMP-binding (487..925): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RWMAFDTHAEEPDLILGADVNSYGPTETTVIAAT
Nearest Stachelhaus code(s):: Lys DTEDIGSVIK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
DasR	N-acetylglucosamine dependent repressor
DmdR1	Iron(II)-dependent repressor

NZ_KZ819178.1 - Region 16 - lassopeptide

Download region SVG

Location: 3,319,180 - 3,341,785 nt. (total: 22,606 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DBP20_RS15000: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

Hydrolases: hydrolase

DBP20_RS14925: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

DBP20_RS14950: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002425.3	0.75	ribosomal	stlassin	Streptomyces sp.
BGC0002053.3	0.71	ribosomal	ulleungdin	Streptomyces sp.
BGC0001507.3	0.67	ribosomal	anantin C	Streptomyces olindensis
BGC0000575.5	0.66	ribosomal	lariatin	Rhodococcus jostii
BGC0001551.4	0.65	ribosomal	citrulassin E	Streptomyces glaucescens
BGC0002289.2	0.65	ribosomal	Leepeptin	Streptomyces leeuwenhoekii
BGC0001889.2	0.65	ribosomal	fusilassin	Thermobifida fusca YX
BGC0001539.4	0.64	ribosomal	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001549.3	0.62	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001506.5	0.59	ribosomal	anantin B1, anantin B2	Streptomyces sp. NRRL S-146

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002425.3	0.75	ribosomal	stlassin	Streptomyces sp.
BGC0002053.3	0.71	ribosomal	ulleungdin	Streptomyces sp.
BGC0001507.3	0.67	ribosomal	anantin C	Streptomyces olindensis
BGC0000575.5	0.66	ribosomal	lariatin	Rhodococcus jostii
BGC0001551.4	0.65	ribosomal	citrulassin E	Streptomyces glaucescens
BGC0002289.2	0.65	ribosomal	Leepeptin	Streptomyces leeuwenhoekii
BGC0001889.2	0.65	ribosomal	fusilassin	Thermobifida fusca YX
BGC0001539.4	0.64	ribosomal	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001549.3	0.62	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001506.5	0.59	ribosomal	anantin B1, anantin B2	Streptomyces sp. NRRL S-146

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.60 out of 29.72

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.02 out of 25.31

Confidence: medium

Additional weak hits (4):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.64 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.11 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.32 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 28.19

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 2 - 84; Score: 89.9

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CatR	H2O2-responsive repressor
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence

NZ_KZ819178.1 - Region 17 - lanthipeptide-class-ii

BGC0001229.4 (SBI_06989):

Download region SVG

Location: 4,057,621 - 4,083,949 nt. (total: 26,329 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

DBP20_RS18490: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Lyases: cyclase hydratase

DBP20_RS18440: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

DBP20_RS18450: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

DBP20_RS18465: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5	0.55	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3	0.54	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0002663.2	0.52	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5	0.55	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3	0.54	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0002663.2	0.52	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for DBP20_RS18440

DBP20_RS18445

Leader:

MGDIAMNDATGYVSADELVELADA

Core:

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

Core with dehydrations:

PDDhaLAAGFDhbPDhbIIPADhbAVDhbDhbVIVGADhaAAMQGGCysPDhbDhaGCysDhbKRCys

antiSMASH-DB 4.0 matches for DBP20_RS18445

100.0%

NZ_BMRY01000003.1and 9 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide

Lanthipeptides: IE140_RS12360_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

97.6%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

95.2%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PDSLAAG TPTI+PATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

with 80 more sequence matches

Only the first 10 are displayed here.

81.0%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAG TPTI+PAT V IVGASAA+QGGCPTSGCTKRC

1

PESLAAGITPTILPATGV---IVGASAALQGGCPTSGCTKRC

39

42.9%

NZ_CKMQ01000043.1and 8 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide

Lanthipeptides: AE832_RS09950_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTIIPAT + G CPTSGCTK C

2

TPTIIPATISFVGVTFTVTLNAGACPTSGCTKSC

35

40.5%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

9

TPTIIPATAV----TTVIVGASAAMQGGCPTSGCTKRC

42

TPT++ + TT V SAA CPTS CTK+C

2

TPTVVLTATIGLTGTTFTVTLSAA---SCPTSACTKQC

36

40.5%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTII AT + G CPTSGCTK C

2

TPTIIAATISFAGVTFTVTLNAGACPTSGCTKSC

35

38.1%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P S A +TP I T V A+ CPTS CT+ C

3

PASPATPYTPAIGKGVIAVTAFVSANT-----CPTSACTRAC

39

38.1%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

2

DSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

+S AG TP I+ A + T + Q CPTS C+K C

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

35.7%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

14

PATAVTTVIVGASAAMQGG-CPTSGCTKRC

42

PAT T VIV SA + CPT+ CT+ C

3

PATPATPVIVAVSAYVSDKTCPTTACTRAC

32

35.7%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTI+ AT TV + CPT+ CT RC

11

TPTIVEATIAATVSI---------CPTTKCTSRC

35

35.7%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

8

FTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTI+ TAVT I CPT+ CT+ C

1

ITPTIV-ITAVTGYI------STNTCPTTSCTRAC

28

35.4%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02295_lanthipeptide

Lanthipeptides: BN6628_RS02295_lanthipeptide

2

DSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

+ + G+TP AT V +VI A CPTS CTK C

13

EDVKGGWTPV---ATVVISVIGLTMNATP--CPTSACTKSC

48

MIBiG 4.0 matches for DBP20_RS18445

31.0%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

VIVGASAAMQGGCPTSGCTKRC

42

V VG SAA CPT+ CT RC

19

VAVGVSAAF---CPTTKCTSRC

37

16.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

14

PATAVTTVIVGASAAMQGGC

33

P T +V SA GC

4

PCTIYASVSASISATASWGC

23

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

33

CPTSGCTKRC

42

CPT+ CT +C

17

CPTTKCTSKC

26

DBP20_RS18455

Leader:

MANPNVGILEEIDDQNLDAVSAA

Core:

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

Core with dehydrations:

GQGWGDhbIVDhaDhaLDhaCysYGADhaYVLGNNGNFCysDhbADhbAECysQNNCysK

antiSMASH-DB 4.0 matches for DBP20_RS18455

100.0%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

94.7%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT++SSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

89.5%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT +SSLSCYGASYVLGNNGNFCTATAECQ+NC+

1

GQGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSNCQ

38

with 112 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

2

QGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

QG GT V++LSCYG S+ LGN+GNFCTAT ECQ+NCK

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

66.7%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

55.3%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++L+C GASY LG+ G CTAT EC NNC+

3

WGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

52.6%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

3

GW-GTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GW G S +SC S+ LGN+G CT TAECQ CK

1

GWTGVAKSIVSCSLISFALGNDGWICTWTAECQATCK

37

50.0%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

2

QGWG-TIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

+ W TI++SL+C ASY+LGN G+ CT T ECQ C

3

ERWAETILTSLACAAASYILGNPGHVCTLTVECQKKC

39

50.0%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++LSC AS ++G+ G CT T ECQNNC+

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

3

GWGTIVSSL-SCYGASYVLGNNGNFCTATAECQNNCK

38

GW + S+ SC S LGN+G CT TAECQ C+

1

GWTGVAKSITSCSLLSIGLGNDGWVCTWTAECQATCR

37

47.4%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

5

GTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GTI +LS Y +GN+G CT T ECQNNC

5

GTISITLSVY-----MGNDGKVCTWTVECQNNC

32

47.4%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide

Lanthipeptides: GHI93_RS00065_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

G W + SS+ + LGNNG CT T ECQ NCK

1

GWTWNLVFSSV----VTLALGNNGYVCTWTHECQANCK

34

44.7%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

6

TIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

TI +++ AS+ LGNNG+ CT T ECQ NC+

1

TIFETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

MIBiG 4.0 matches for DBP20_RS18455

36.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

14

YGASYVLGNNGNFCTATAECQNNC

37

+ S LGNNG +CT T ECQ NC

6

FSLSNALGNNGGWCTLTKECQPNC

29

31.6%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

14

YGASYVLGNNGNFCTATAECQNNC

37

Y S LGN G +CT T EC +C

4

YNISCRLGNKGAYCTLTVECMPSC

27

17.9%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTATAECQNNC

37

CT + ECQ NC

28

CTLSKECQPNC

38

allorf_4060172_4060351

Leader:

MVRSSYFQWADGVWGHSGRNGFLGPTFGG

Core:

APPEAAHGPWRTSPGCVPPDGVSSRFRHGT

Core with dehydrations:

APPEAAHGPWRDhbDhaPGCysVPPDGVDhaDhaRFRHGDhb

antiSMASH-DB 4.0 matches for allorf_4060172_4060351

100.0%

NZ_BMRY01000003.1and 4 others:

NZ_CP084357.1 Lanthipeptides: allorf_8065428_8065607_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: allorf_198894_199073_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4060172_4060351_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: allorf_787745_787924_lanthipeptide

Lanthipeptides: allorf_443301_443480_lanthipeptide

1

APPEAAHGPWRTSPGCVPPDGVSSRFRHGT

30

APPEAAHGPWRTSPGCVPPDGVSSRFRHGT

1

APPEAAHGPWRTSPGCVPPDGVSSRFRHGT

30

30.3%

NZ_CP022088.2:

Lanthipeptides: CEQ30_RS41055_lanthipeptide

3

PEAAHGPWRTSPGCVPPDGVSS

24

P AA RT+ G P D SS

1

PHAAPMVMRTAEGTCPSDDCSS

22

26.7%

NZ_LN850107.1:

Lanthipeptides: BN1701_RS15195_lanthipeptide

3

PEAAHGPWRTSPGCVPPD

20

P G W TS C P D

4

PATLSGIWPTSTTCCPED

21

with 3 more sequence matches

17.8%

NZ_CP102973.1and 1 other:

NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14440_lanthipeptide

Lanthipeptides: NW963_RS14080_lanthipeptide

7

HGPWRTSPGCVPPDGVSSR

25

+G + TSP CV +SR

4

NGEFTTSPACVYSAVFASR

22

17.8%

NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12140_lanthipeptide

Lanthipeptides: IV75_RS14640_lanthipeptide

7

HGPWRTSPGCVPPDGVSSR

25

+G + TSP CV V S+

4

NGEFTTSPACVYSVMVVSK

22

16.3%

NZ_JADNGS010000002.1:

Lanthipeptides: I2D92_RS06835_lanthipeptide

8

GPWRTSPGCVPPDGVSSR

25

G + TSP CV +SR

5

GEFTTSPACVYVSVAASR

22

allorf_4060176_4060337

Leader:

MPWRKRLDTPSGG

Core:

TQPGLVRHGPCAASGGAPPKVGPRNPFLPECPHTPSAHWK

Core with dehydrations:

DhbQPGLVRHGPCysAADhaGGAPPKVGPRNPFLPECysPHDhbPDhaAHWK

antiSMASH-DB 4.0 matches for allorf_4060176_4060337

100.0%

NZ_BMRY01000003.1and 4 others:

NZ_CP084357.1 Lanthipeptides: allorf_8065442_8065603_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: allorf_198908_199069_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4060176_4060337_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: allorf_787759_787920_lanthipeptide

Lanthipeptides: allorf_443305_443466_lanthipeptide

1

TQPGLVRHGPCAASGGAPPKVGPRNPFLPECPHTPSAHWK

40

TQPGLVRHGPCAASGGAPPKVGPRNPFLPECPHTPSAHWK

1

TQPGLVRHGPCAASGGAPPKVGPRNPFLPECPHTPSAHWK

40

27.5%

NZ_CP035042.1:

Lassopeptides: allorf_3065580_3065849_lassopeptide

4

GLVRHGPCAASGGAPPKVGPRNP

26

GL R G G AP G RNP

2

GLTRPGSDVFPGNAPHSNGSRNP

24

20.0%

NZ_CP097263.1:

Lanthipeptides: M3Q35_RS22080_lanthipeptide

25

NPFLPECPHTPSAH

38

+PF ECP T S H

12

DPFTQECPDTDSCH

25

with 2 more sequence matches

18.3%

NZ_JACHGN010000015.1:

Lanthipeptides: allorf_120347_120571_lanthipeptide

7

RHGPCAASGGA-PPKVGPRNPFLPECPHT

34

RH P A + GA P+V R EC

32

RHAPRACTAGAGSPQVSRRRRMRCECDRD

60

17.5%

NZ_JALBFU010000008.1:

Lanthipeptides: allorf_83215_83337_lanthipeptide

8

HGPCAASGGAPP

19

H PC GG PP

3

HSPCRVRGGLPP

14

MIBiG 4.0 matches for allorf_4060176_4060337

12.5%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

17

APPKVGPRNPFLP

29

A VG F P

17

AGVAVGVSAAFCP

29

allorf_4075416_4075610

Leader:

MKSRRWGKGGREGCRNVPAG

Core:

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

Core with dehydrations:

LDDhaEPLPERDhaGRFHRPAVRPPDhaPLLLRPRCysPWDhbPDhaPRPWNWDhaCysV

antiSMASH-DB 4.0 matches for allorf_4075416_4075610

100.0%

NZ_KZ819178.1and 1 other:

NZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide

Lanthipeptides: allorf_4075416_4075610_lanthipeptide

1

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

1

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

93.2%

NZ_CP084357.1and 1 other:

NZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptide

Lanthipeptides: allorf_8050125_8050319_lanthipeptide

1

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

LDSEPLPERSG H PAVRPPSPLLLRPRCPWTPSPRPWNWSCV

1

LDSEPLPERSGSLHCPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

88.6%

NZ_BMRY01000003.1and 1 other:

NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptide

Lanthipeptides: allorf_458543_458737_lanthipeptide

1

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

LDSEPLPERSG P VRPPSPLLLRPRCPWTPSPRPWNWSCV

1

LDSEPLPERSGSLRCPFVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

with 8 more sequence matches

22.7%

NZ_BMSZ01000006.1and 2 others:

NZ_BMSZ01000006.1 Lanthipeptides: allorf_235964_236128_lanthipeptideNZ_CP021707.1 Lanthipeptides: allorf_3962821_3962985_lanthipeptide

Lanthipeptides: allorf_235964_236128_lanthipeptide

34

PSPRPWNWSCV

44

PSPRPWN SCV

12

PSPRPWNRSCV

22

20.5%

NZ_BDFA01000012.1and 5 others:

NZ_CP025018.1 Lanthipeptides: allorf_10559500_10559625_lanthipeptideNZ_CP029823.1 Lanthipeptides: allorf_10618379_10618504_lanthipeptideNZ_CP065050.1 Lanthipeptides: allorf_00914926_00915051_lanthipeptideNZ_JAALLH010000001.1 Lanthipeptides: allorf_0868535_0868660_lanthipeptideNZ_LJIW01000001.1 Lanthipeptides: allorf_0970869_0970994_lanthipeptide

Lanthipeptides: allorf_122369_122494_lanthipeptide

10

SGRFHRPAVRPPSPLLLRPRC

30

+GRFH AV PL C

3

TGRFHECAVEQLPPLYRLVTC

23

19.3%

NC_019673.1:

Lanthipeptides: allorf_7149539_7149760_lanthipeptide

19

RPPSPLLLRPRCPWTPSPRPWNWSC

43

R PS L+L RC P W SC

22

RSPSRLVLTIRCTE-PVSHDWTRSC

45

18.5%

NZ_CP008953.1:

Lanthipeptides: allorf_3865033_3865224_lanthipeptide

14

HRPAVRPPSPLLLRPRCPWTPSPRPWNWS

42

+RPA P P R RCP + P++ +

6

NRPASGPARPWCDRDRCPRMGAGTPYSGA

34

18.2%

NZ_JALDPQ010000054.1and 1 other:

NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114966_115073_lanthipeptide

Lanthipeptides: allorf_114966_115073_lanthipeptide

35

SPRPWNWSCV

44

+P PWNWSCV

15

TPPPWNWSCV

24

16.1%

NZ_JAAXRC010000001.1:

Lanthipeptides: allorf_597683_597922_lanthipeptide

8

ERSGRFHRPAVRPPSPLLL

26

+ S F RPAVR P LL

43

DASSEFCRPAVRKPRHHLL

61

15.9%

NZ_MQUQ01000028.1:

Lassopeptides: BS329_RS43115_lassopeptide

3

SEPLPERSGRFHRP

16

S LPE G ++RP

4

SVGLPEGDGSYNRP

17

12.7%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: allorf_335018_335257_lanthipeptide

Lanthipeptides: allorf_335018_335257_lanthipeptide

2

DSEPLPERSGRFHRPAV

18

D+ PER G + PAV

46

DAANSPERDGNYRLPAV

62

Lanthipeptide(s) for DBP20_RS18450

DBP20_RS18445

Leader:

MGDIAMNDATGYVSADELVELADA

Core:

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

Core with dehydrations:

PDDhaLAAGFDhbPDhbIIPADhbAVDhbDhbVIVGADhaAAMQGGCysPDhbDhaGCysDhbKRCys

antiSMASH-DB 4.0 matches for DBP20_RS18445

100.0%

NZ_BMRY01000003.1and 9 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide

Lanthipeptides: IE140_RS12360_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

97.6%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

95.2%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PDSLAAG TPTI+PATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

with 80 more sequence matches

Only the first 10 are displayed here.

81.0%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAG TPTI+PAT V IVGASAA+QGGCPTSGCTKRC

1

PESLAAGITPTILPATGV---IVGASAALQGGCPTSGCTKRC

39

42.9%

NZ_CKMQ01000043.1and 8 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide

Lanthipeptides: AE832_RS09950_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTIIPAT + G CPTSGCTK C

2

TPTIIPATISFVGVTFTVTLNAGACPTSGCTKSC

35

40.5%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

9

TPTIIPATAV----TTVIVGASAAMQGGCPTSGCTKRC

42

TPT++ + TT V SAA CPTS CTK+C

2

TPTVVLTATIGLTGTTFTVTLSAA---SCPTSACTKQC

36

40.5%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTII AT + G CPTSGCTK C

2

TPTIIAATISFAGVTFTVTLNAGACPTSGCTKSC

35

38.1%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P S A +TP I T V A+ CPTS CT+ C

3

PASPATPYTPAIGKGVIAVTAFVSANT-----CPTSACTRAC

39

38.1%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

2

DSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

+S AG TP I+ A + T + Q CPTS C+K C

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

35.7%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

14

PATAVTTVIVGASAAMQGG-CPTSGCTKRC

42

PAT T VIV SA + CPT+ CT+ C

3

PATPATPVIVAVSAYVSDKTCPTTACTRAC

32

35.7%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTI+ AT TV + CPT+ CT RC

11

TPTIVEATIAATVSI---------CPTTKCTSRC

35

35.7%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

8

FTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTI+ TAVT I CPT+ CT+ C

1

ITPTIV-ITAVTGYI------STNTCPTTSCTRAC

28

35.4%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02295_lanthipeptide

Lanthipeptides: BN6628_RS02295_lanthipeptide

2

DSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

+ + G+TP AT V +VI A CPTS CTK C

13

EDVKGGWTPV---ATVVISVIGLTMNATP--CPTSACTKSC

48

MIBiG 4.0 matches for DBP20_RS18445

31.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

VIVGASAAMQGGCPTSGCTKRC

42

V VG SAA CPT+ CT RC

19

VAVGVSAAF---CPTTKCTSRC

37

16.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

14

PATAVTTVIVGASAAMQGGC

33

P T +V SA GC

4

PCTIYASVSASISATASWGC

23

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

33

CPTSGCTKRC

42

CPT+ CT +C

17

CPTTKCTSKC

26

DBP20_RS18455

Leader:

MANPNVGILEEIDDQNLDAVSAA

Core:

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

Core with dehydrations:

GQGWGDhbIVDhaDhaLDhaCysYGADhaYVLGNNGNFCysDhbADhbAECysQNNCysK

antiSMASH-DB 4.0 matches for DBP20_RS18455

100.0%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

94.7%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT++SSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

89.5%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT +SSLSCYGASYVLGNNGNFCTATAECQ+NC+

1

GQGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSNCQ

38

with 112 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

2

QGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

QG GT V++LSCYG S+ LGN+GNFCTAT ECQ+NCK

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

66.7%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

55.3%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++L+C GASY LG+ G CTAT EC NNC+

3

WGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

52.6%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

3

GW-GTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GW G S +SC S+ LGN+G CT TAECQ CK

1

GWTGVAKSIVSCSLISFALGNDGWICTWTAECQATCK

37

50.0%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

2

QGWG-TIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

+ W TI++SL+C ASY+LGN G+ CT T ECQ C

3

ERWAETILTSLACAAASYILGNPGHVCTLTVECQKKC

39

50.0%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++LSC AS ++G+ G CT T ECQNNC+

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

3

GWGTIVSSL-SCYGASYVLGNNGNFCTATAECQNNCK

38

GW + S+ SC S LGN+G CT TAECQ C+

1

GWTGVAKSITSCSLLSIGLGNDGWVCTWTAECQATCR

37

47.4%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

5

GTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GTI +LS Y +GN+G CT T ECQNNC

5

GTISITLSVY-----MGNDGKVCTWTVECQNNC

32

47.4%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide

Lanthipeptides: GHI93_RS00065_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

G W + SS+ + LGNNG CT T ECQ NCK

1

GWTWNLVFSSV----VTLALGNNGYVCTWTHECQANCK

34

44.7%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

6

TIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

TI +++ AS+ LGNNG+ CT T ECQ NC+

1

TIFETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

MIBiG 4.0 matches for DBP20_RS18455

36.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

14

YGASYVLGNNGNFCTATAECQNNC

37

+ S LGNNG +CT T ECQ NC

6

FSLSNALGNNGGWCTLTKECQPNC

29

31.6%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

14

YGASYVLGNNGNFCTATAECQNNC

37

Y S LGN G +CT T EC +C

4

YNISCRLGNKGAYCTLTVECMPSC

27

17.9%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTATAECQNNC

37

CT + ECQ NC

28

CTLSKECQPNC

38

allorf_4075416_4075610

Leader:

MKSRRWGKGGREGCRNVPAG

Core:

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

Core with dehydrations:

LDDhaEPLPERDhaGRFHRPAVRPPDhaPLLLRPRCysPWDhbPDhaPRPWNWDhaCysV

antiSMASH-DB 4.0 matches for allorf_4075416_4075610

100.0%

NZ_KZ819178.1and 1 other:

NZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide

Lanthipeptides: allorf_4075416_4075610_lanthipeptide

1

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

1

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

93.2%

NZ_CP084357.1and 1 other:

NZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptide

Lanthipeptides: allorf_8050125_8050319_lanthipeptide

1

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

LDSEPLPERSG H PAVRPPSPLLLRPRCPWTPSPRPWNWSCV

1

LDSEPLPERSGSLHCPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

88.6%

NZ_BMRY01000003.1and 1 other:

NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptide

Lanthipeptides: allorf_458543_458737_lanthipeptide

1

LDSEPLPERSGRFHRPAVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

LDSEPLPERSG P VRPPSPLLLRPRCPWTPSPRPWNWSCV

1

LDSEPLPERSGSLRCPFVRPPSPLLLRPRCPWTPSPRPWNWSCV

44

with 8 more sequence matches

22.7%

NZ_BMSZ01000006.1and 2 others:

NZ_BMSZ01000006.1 Lanthipeptides: allorf_235964_236128_lanthipeptideNZ_CP021707.1 Lanthipeptides: allorf_3962821_3962985_lanthipeptide

Lanthipeptides: allorf_235964_236128_lanthipeptide

34

PSPRPWNWSCV

44

PSPRPWN SCV

12

PSPRPWNRSCV

22

20.5%

NZ_BDFA01000012.1and 5 others:

NZ_CP025018.1 Lanthipeptides: allorf_10559500_10559625_lanthipeptideNZ_CP029823.1 Lanthipeptides: allorf_10618379_10618504_lanthipeptideNZ_CP065050.1 Lanthipeptides: allorf_00914926_00915051_lanthipeptideNZ_JAALLH010000001.1 Lanthipeptides: allorf_0868535_0868660_lanthipeptideNZ_LJIW01000001.1 Lanthipeptides: allorf_0970869_0970994_lanthipeptide

Lanthipeptides: allorf_122369_122494_lanthipeptide

10

SGRFHRPAVRPPSPLLLRPRC

30

+GRFH AV PL C

3

TGRFHECAVEQLPPLYRLVTC

23

19.3%

NC_019673.1:

Lanthipeptides: allorf_7149539_7149760_lanthipeptide

19

RPPSPLLLRPRCPWTPSPRPWNWSC

43

R PS L+L RC P W SC

22

RSPSRLVLTIRCTE-PVSHDWTRSC

45

18.5%

NZ_CP008953.1:

Lanthipeptides: allorf_3865033_3865224_lanthipeptide

14

HRPAVRPPSPLLLRPRCPWTPSPRPWNWS

42

+RPA P P R RCP + P++ +

6

NRPASGPARPWCDRDRCPRMGAGTPYSGA

34

18.2%

NZ_JALDPQ010000054.1and 1 other:

NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114966_115073_lanthipeptide

Lanthipeptides: allorf_114966_115073_lanthipeptide

35

SPRPWNWSCV

44

+P PWNWSCV

15

TPPPWNWSCV

24

16.1%

NZ_JAAXRC010000001.1:

Lanthipeptides: allorf_597683_597922_lanthipeptide

8

ERSGRFHRPAVRPPSPLLL

26

+ S F RPAVR P LL

43

DASSEFCRPAVRKPRHHLL

61

15.9%

NZ_MQUQ01000028.1:

Lassopeptides: BS329_RS43115_lassopeptide

3

SEPLPERSGRFHRP

16

S LPE G ++RP

4

SVGLPEGDGSYNRP

17

12.7%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: allorf_335018_335257_lanthipeptide

Lanthipeptides: allorf_335018_335257_lanthipeptide

2

DSEPLPERSGRFHRPAV

18

D+ PER G + PAV

46

DAANSPERDGNYRLPAV

62

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.33 out of 19.52

Confidence: strong

Additional weak hits (7):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 35.63

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.20 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.10 out of 30.11

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.66 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.04 out of 27.78

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.51 out of 33.14

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

DBP20_RS18445 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 3841.0 Da

Molecular weight: 3843.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3861.5 Da N = 1; 3879.5 Da N = 2; 3897.5 Da N = 3; 3915.5 Da N = 4; 3933.5 Da N = 5; 3951.6 Da N = 6; 3969.6 Da N = 7

DBP20_RS18455 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 3790.7 Da

Molecular weight: 3793.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3811.2 Da N = 1; 3829.2 Da N = 2; 3847.2 Da N = 3

allorf_4060172_4060351 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 3035.5 Da

Molecular weight: 3037.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3055.3 Da N = 1; 3073.4 Da N = 2; 3091.4 Da N = 3; 3109.4 Da N = 4

allorf_4060176_4060337 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 4079.1 Da

Molecular weight: 4081.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4099.6 Da N = 1; 4117.7 Da N = 2

allorf_4075416_4075610 - Class II

Cleavage pHMM score: -5.30

RODEO score: 0

Monoisotopic mass: 5033.7 Da

Molecular weight: 5036.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 5054.8 Da N = 1; 5072.8 Da N = 2; 5090.8 Da N = 3; 5108.9 Da N = 4

DBP20_RS18445 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 3841.0 Da

Molecular weight: 3843.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3861.5 Da N = 1; 3879.5 Da N = 2; 3897.5 Da N = 3; 3915.5 Da N = 4; 3933.5 Da N = 5; 3951.6 Da N = 6; 3969.6 Da N = 7

DBP20_RS18455 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 3790.7 Da

Molecular weight: 3793.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3811.2 Da N = 1; 3829.2 Da N = 2; 3847.2 Da N = 3

allorf_4075416_4075610 - Class II

Cleavage pHMM score: -5.30

RODEO score: 0

Monoisotopic mass: 5033.7 Da

Molecular weight: 5036.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 5054.8 Da N = 1; 5072.8 Da N = 2; 5090.8 Da N = 3; 5108.9 Da N = 4

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
RpoN	Regulator of nitrogen assimilation and virulence

NZ_KZ819178.1 - Region 18 - NRPS,NRPS-like,arylpolyene,lassopeptide,terpene-precursor

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Location: 4,287,091 - 4,410,454 nt. (total: 123,364 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
arylpolyene: (APE_KS1 or APE_KS2)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Select a gene to view the details available for it

Gene overview

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

DBP20_RS19555: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DBP20_RS19585: Dioxygenase TauD/TfdA

smcogs: SMCOG1046: Dioxygenase TauD/TfdA

DBP20_RS19590: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DBP20_RS19630: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DBP20_RS19710: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS19740: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

DBP20_RS36130: Dioxygenase TauD/TfdA

smcogs: SMCOG1046: Dioxygenase TauD/TfdA

Transferases: acyltransferase methyltransferase transferase

DBP20_RS19625: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

DBP20_RS19635: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

DBP20_RS19770: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: deaminase esterase hydrolase

DBP20_RS19655: thioesterase

smcogs: SMCOG1004: thioesterase

DBP20_RS19730: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

DBP20_RS19760: thioesterase

smcogs: SMCOG1004: thioesterase

DBP20_RS19855: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Ligases: ligase synthase synthetase

DBP20_RS19545: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

DBP20_RS19595: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS19600: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS19605: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS19670: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS19675: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS19720: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS19735: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	1.05	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	1.02	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	1.00	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.99	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001261.3	0.97	NRPS	AM-toxin	Alternaria alternata
BGC0001825.4	0.97	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.96	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002135.2	0.94	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001641.4	0.93	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.87	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.3	0.87	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001261.3	0.73	NRPS	AM-toxin	Alternaria alternata
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.72	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

Lasso peptide predictions

Lassopeptides - No core peptides found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

DBP20_RS19545: PT_FPPS_like

Domain 1 (64 - 348): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.83 out of 20.47

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.62 out of 27.78

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (27):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.49 out of 25.88

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.58 out of 21.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.83 out of 21.55

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.16 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.35 out of 24.78

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.54 out of 20.01

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.75 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.10 out of 39.62

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.10 out of 20.97

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.29 out of 18.57

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.26 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.29 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.31 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.03 out of 30.22

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.34 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.11 out of 26.06

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.65 out of 22.40

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.67 out of 18.57

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.82 out of 36.53

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.70 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.11 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.90 out of 35.63

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.76 out of 27.04

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.52 out of 29.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.81 out of 18.57

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.98 out of 28.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

Lasso peptides

NRPS/PKS products

NRPS/PKS substrates

RREFinder

Terpene

TFBS Finder

Core peptide predictions

No core peptides found.

Predicted core structure(s)

For candidate cluster 22, location 4287090 - 4410454:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Asn) + (D-Leu - Asp - D-X) + (D-X - X - Val) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 24, location 4292952 - 4369583:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Asn) + (D-Leu - Asp - D-X) + (D-X - X - Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 25, location 4342575 - 4383706:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (D-X - X - Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 26, location 4349847 - 4392262:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS19595: Asn

Search NORINE for peptide: strict or relaxed

AMP-binding (1025..1415): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YYASFDLTVTAAKAVVGGEVNEYGPTEATVGCVE
Nearest Stachelhaus code(s):: Asn DLTKVGEVGK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

DBP20_RS19600: Leu - Asp - X

Search NORINE for peptide: strict or relaxed

AMP-binding (461..854): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FTESFDASVLEMLIIVGGDVNAYGPTESTVAVSI
Nearest Stachelhaus code(s):: Leu DALLIGAVAK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1985..2387): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWTSFDLTVTATKALLGGEWNVYGPTEATVNVTE
Nearest Stachelhaus code(s):: Asp DLTKLGVVNK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3048..3447): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: MAHVFDVSMADMQIAVGGELNVYGPSETTVCATM
Nearest Stachelhaus code(s):: Trp DVAMVGAVCK (76% 8Å match); Ahp DVENAGVVTK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

DBP20_RS19605: X - X - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (1505..1881): X

nrpys: Gly, Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LAVAFDIAVMELEA-TAGETNLYGPTETTVYSTG
Nearest Stachelhaus code(s):: Ala DIFQLALVYK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (3027..3426): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSHIFDVSVADMQLVTGGEINAYGPTETMVCATM
Nearest Stachelhaus code(s):: Trp DVAMVGAVCK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (4086..4481): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: MDESFDALSYEAFLLTGGEAHVYGPTETTTYATR
Nearest Stachelhaus code(s):: Val or aIle DAYFLGVTFK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

DBP20_RS19720: X

AMP-binding (225..627): X

nrpys: Dpr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HAKAFDISLWQAQASVTGEMNAYGLTETSDDTNH
Nearest Stachelhaus code(s):: Dpr DIWQSTADDK (91% 8Å match); dnmeProp or Dab DIWQSTADDK (82% 8Å match); Asp DIWQSTADDK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 0 - 82; Score: 87.5

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 19 - lanthipeptide-class-iv

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Location: 4,508,817 - 4,531,699 nt. (total: 22,883 nt) Show pHMM detection rules used

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.61	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000501.3	0.59	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.5	0.59	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000563.4	0.58	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000513.3	0.57	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0002337.2	0.57	ribosomal	class IV lanthipeptide, SflA	Streptomyces sp. NRRL S-1022
BGC0000519.4	0.56	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000553.3	0.47	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002447.3	0.46	ribosomal	cerecyclin	Bacillus cereus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.61	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000501.3	0.59	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.5	0.59	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000563.4	0.58	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000513.3	0.57	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0002337.2	0.57	ribosomal	class IV lanthipeptide, SflA	Streptomyces sp. NRRL S-1022
BGC0000519.4	0.56	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000553.3	0.47	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002447.3	0.46	ribosomal	cerecyclin	Bacillus cereus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for DBP20_RS20455

DBP20_RS35670

Leader:

MIDNTMTVDVDELQTLEGEESVALAG

Core:

CTRTCTWTCSITSIEQQ

Core with dehydrations:

CysDhbRDhbCysDhbWDhbCysDhaIDhbDhaIEQQ

antiSMASH-DB 4.0 matches for DBP20_RS35670

100.0%

NZ_BMRY01000001.1and 16 others:

NZ_BNBJ01000011.1 Lanthipeptides: IE304_RS20740_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36570_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS35105_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS21260_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS33035_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS20475_lanthipeptideNZ_JALDPQ010000041.1 Lanthipeptides: MQC87_RS04410_lanthipeptideNZ_JAMFLF010000024.1 Lanthipeptides: M1212_RS34580_lanthipeptideNZ_KL573566.1 Lanthipeptides: BG84_RS1000000140120_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35670_lanthipeptideNZ_KZ819182.1 Lanthipeptides: DBP21_RS35710_lanthipeptideNZ_LIVT01000009.1 Lanthipeptides: AMK24_RS34305_lanthipeptideNZ_LIXK01000001.1 Lanthipeptides: AMK23_RS37735_lanthipeptideNZ_ML123117.1 Lanthipeptides: EES46_RS36000_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS33060_lanthipeptideNZ_WWGD01000043.1 Lanthipeptides: GTY72_RS37555_lanthipeptide

Lanthipeptides: IE140_RS05545_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

CTRTCTWTCSITSIEQQ

1

CTRTCTWTCSITSIEQQ

17

94.1%

NZ_JNLT01000004.1:

Lanthipeptides: CD02_RS38845_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

CT+TCTWTCSITSIEQQ

1

CTKTCTWTCSITSIEQQ

17

82.4%

NZ_LZRD01000027.1:

Lanthipeptides: A3Q37_RS37510_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

CT+TCTWTC ITS+EQQ

1

CTKTCTWTCRITSLEQQ

17

with 8 more sequence matches

82.4%

NZ_ML123034.1:

Lanthipeptides: EES43_RS30965_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

CT TC WTC+ITSIEQQ

1

CTATCAWTCAITSIEQQ

17

72.2%

NZ_PGGV01000018.1:

Lanthipeptides: CUT39_RS20215_lanthipeptide

1

CTRTCTWTCSITSIEQ

16

CT TCTWTCSITS +Q

3

CTWTCTWTCSITSFQQ

18

40.9%

NZ_CP017708.2and 1 other:

NZ_CP017708.2 Lanthipeptides: BJP36_RS08575_lanthipeptide

Lanthipeptides: BJP36_RS08575_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

C TC +TC +T I+QQ

1

CGHTCGYTCGVTEIKQQ

17

38.9%

NZ_CP017599.1and 1 other:

NZ_CP017599.1 Lanthipeptides: BJP34_RS13165_lanthipeptide

Lanthipeptides: BJP34_RS13165_lanthipeptide

4

TCTWTCSITSIEQQ

17

+CT +C IT I Q

3

SCTVSCLITIINNQ

16

33.3%

NC_017803.1:

Lanthipeptides: ACPL_RS45060_lanthipeptide

1

CTRTCTWTCSITS

13

C TC TCS+T

8

CKGTCPATCSVTG

20

33.3%

NZ_BROP01000004.1:

Lanthipeptides: OPC11_RS12060_lanthipeptide

1

CTRTCTWTCSIT

12

C TCT +C++T

4

CLLTCTVSCAVT

15

25.0%

NZ_VATK01000028.1:

Lanthipeptides: FDO66_RS19480_lanthipeptide

3

RTCTWTCSIT

12

R C W CS T

1

RPCGWICSYT

10

9.8%

NZ_CP040414.1:

Lanthipeptides: FE331_RS05905_lanthipeptide

1

CTRTCTWTC

9

C R+C W C

38

CNRSCGWGC

46

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

Additional weak hits (4):

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.70 out of 27.04

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.18 out of 26.85

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.38 out of 28.19

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

DBP20_RS35670 - Class III

Cleavage pHMM score: 2.70

RODEO score: 0

Monoisotopic mass: 1833.8 Da

Molecular weight: 1835.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 1853.1 Da N = 1; 1871.1 Da N = 2; 1889.1 Da N = 3; 1907.1 Da N = 4

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_KZ819178.1 - Region 20 - NRPS-like,T1PKS

Download region SVG

Location: 5,132,901 - 5,187,572 nt. (total: 54,672 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

DBP20_RS23415: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

DBP20_RS23480: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS23540: dihydropteridine reductase

smcogs: SMCOG1159: dihydropteridine reductase

Transferases: aminotransferase

DBP20_RS23495: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: esterase

DBP20_RS23485: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: lyase

DBP20_RS23465: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase

DBP20_RS23475: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS23500: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: permease

DBP20_RS23560: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.83	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.70	NRPS	peramine	Epichloe festucae
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.68	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.68	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.68	NRPS	peramine	Epichloe festucae
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.91 out of 23.79

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.88 out of 36.53

Confidence: medium

Additional weak hits (16):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.11 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.36 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.29 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.79 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.61 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.67 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.83 out of 26.06

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.29 out of 33.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.81 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.19 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.18 out of 27.55

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.86 out of 30.22

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.92 out of 28.19

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.25 out of 20.01

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 29, location 5132900 - 5187572:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 30, location 5132900 - 5175483:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 31, location 5144356 - 5187572:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS23475: aThr

Search NORINE for peptide: strict or relaxed

AMP-binding (293..677): aThr

nrpys: aThr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LAVHFDFSVWEGSQVLGGEVNMYGITETTVHVTA
Nearest Stachelhaus code(s):: aThr DFWSVGMVHK (94% 8Å match); Thr DFWSVGMVHK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

DBP20_RS23500: mal

PKS_AT (563..845): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 120.6
inactive: 72.6
Methoxymalonyl-CoA: 59.8
Methylmalonyl-CoA: 56.0
Propionyl-CoA: 34.2
Isobutyryl-CoA: 28.9
Ethylmalonyl-CoA: 28.3
CHC-CoA: 28.2
fatty_acid: 20.8
Benzoyl-CoA: 20.7
Acetyl-CoA: 14.3
2-Methylbutyryl-CoA: 14.1
trans-1,2-CPDA: 13.2
3-Methylbutyryl-CoA: 8.6

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism

NZ_KZ819178.1 - Region 21 - lanthipeptide-class-iii

BGC0000553.3 (SSGG_RS09925):

Download region SVG

Location: 5,258,618 - 5,281,467 nt. (total: 22,850 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase aminotransferase

DBP20_RS23940: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

DBP20_RS23995: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000496.5	0.88	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.74	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000551.5	0.66	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.60	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000518.3	0.55	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.53	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002700.2	0.52	ribosomal	bacinapeptin	Bacillus nakamurai

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000496.5	0.88	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.74	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000551.5	0.66	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.60	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000518.3	0.55	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.53	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002700.2	0.52	ribosomal	bacinapeptin	Bacillus nakamurai

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for DBP20_RS23955

DBP20_RS23960

Leader:

MALLDLQAMDTPAEDSFGELAT

Core:

GSQVSLLVCEYSSLSVVLCTP

Core with dehydrations:

GDhaQVDhaLLVCysEYDhaDhaLDhaVVLCysDhbP

antiSMASH-DB 4.0 matches for DBP20_RS23960

100.0%

NC_010572.1and 60 others:

NC_021177.1 Lanthipeptides: SFUL_RS24355_lanthipeptideNZ_AQRK01000102.1 Lanthipeptides: YUW_RS30025_lanthipeptideNZ_ARPF01000003.1 Lanthipeptides: B083_RS0107255_lanthipeptideNZ_BMRY01000001.1 Lanthipeptides: IE140_RS02070_lanthipeptideNZ_BMSP01000003.1 Lanthipeptides: IE150_RS06495_lanthipeptideNZ_BMSZ01000003.1 Lanthipeptides: IE135_RS07550_lanthipeptideNZ_BMTW01000017.1 Lanthipeptides: IE134_RS28550_lanthipeptideNZ_BMUG01000009.1 Lanthipeptides: IE264_RS25430_lanthipeptideNZ_BMVK01000002.1 Lanthipeptides: IE272_RS07115_lanthipeptideNZ_BNBJ01000002.1 Lanthipeptides: IE304_RS05195_lanthipeptideNZ_CM003601.1 Lanthipeptides: JI76_RS25200_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS10875_lanthipeptideNZ_CP011522.1 Lanthipeptides: ABE83_RS11805_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS23525_lanthipeptideNZ_CP015362.1 Lanthipeptides: A6E92_RS09975_lanthipeptideNZ_CP020563.1 Lanthipeptides: B7C62_RS24450_lanthipeptideNZ_CP020570.1 Lanthipeptides: B1H20_RS34690_lanthipeptideNZ_CP024957.1 Lanthipeptides: CVT27_RS22730_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS10225_lanthipeptideNZ_CP030930.1 Lanthipeptides: DTW94_RS22865_lanthipeptideNZ_CP061072.1 Lanthipeptides: HYC88_RS10560_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS24895_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS29435_lanthipeptideNZ_CP086102.1 Lanthipeptides: LK895_RS11660_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS24025_lanthipeptideNZ_CP096281.1 Lanthipeptides: MWG59_RS25685_lanthipeptideNZ_CP101397.1 Lanthipeptides: NLU04_RS06465_lanthipeptideNZ_CP110539.1 Lanthipeptides: OH133_RS12690_lanthipeptideNZ_CP112880.1 Lanthipeptides: N7925_RS11185_lanthipeptideNZ_CP113262.1 Lanthipeptides: OUQ49_RS22935_lanthipeptideNZ_CP117709.1 Lanthipeptides: PSQ21_RS24530_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS09925_lanthipeptideNZ_GL877172.1 Lanthipeptides: SACT1_RS12960_lanthipeptideNZ_JAAWWP010000002.1 Lanthipeptides: HFV08_RS04115_lanthipeptideNZ_JAGGOV010000004.1 Lanthipeptides: J7E92_RS02930_lanthipeptideNZ_JAHHWT010000009.1 Lanthipeptides: KM153_RS24430_lanthipeptideNZ_JALDPQ010000064.1 Lanthipeptides: MQC87_RS23965_lanthipeptideNZ_JAMFLF010000002.1 Lanthipeptides: M1212_RS07295_lanthipeptideNZ_JANRMN010000004.1 Lanthipeptides: NW249_RS08610_lanthipeptideNZ_JNLT01000003.1 Lanthipeptides: CD02_RS0108685_lanthipeptideNZ_KB890925.1 Lanthipeptides: B053_RS0113845_lanthipeptideNZ_KL573549.1 Lanthipeptides: BG84_RS0119125_lanthipeptideNZ_KQ257779.1 Lanthipeptides: IQ60_RS22540_lanthipeptideNZ_KZ195572.1 Lanthipeptides: B9W61_RS11940_lanthipeptideNZ_KZ679082.1 Lanthipeptides: C6W96_RS24050_lanthipeptideNZ_KZ819154.1 Lanthipeptides: DBP12_RS10285_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS23960_lanthipeptideNZ_KZ819182.1 Lanthipeptides: DBP21_RS24660_lanthipeptideNZ_LACR01000009.1 Lanthipeptides: YW5_RS12280_lanthipeptideNZ_LIPB01000001.1 Lanthipeptides: AMK17_RS03280_lanthipeptideNZ_LIPE01000001.1 Lanthipeptides: AMK12_RS03355_lanthipeptideNZ_LIVT01000001.1 Lanthipeptides: AMK24_RS01700_lanthipeptideNZ_LIVW01000001.1 Lanthipeptides: AMK28_RS03165_lanthipeptideNZ_LIXK01000001.1 Lanthipeptides: AMK23_RS04085_lanthipeptideNZ_LMEL01000012.1 Lanthipeptides: ASD29_RS10010_lanthipeptideNZ_LZRD01000054.1 Lanthipeptides: A3Q37_RS33745_lanthipeptideNZ_ML123117.1 Lanthipeptides: EES46_RS10300_lanthipeptideNZ_NNBN01000004.1 Lanthipeptides: CG717_RS12310_lanthipeptideNZ_VEHK01000004.1 Lanthipeptides: FS984_RS13530_lanthipeptideNZ_WWGD01000029.1 Lanthipeptides: GTY72_RS23245_lanthipeptide

Lanthipeptides: SGR_RS11800_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSVVLCTP

1

GSQVSLLVCEYSSLSVVLCTP

21

95.2%

NZ_BDHJ01000008.1and 4 others:

NZ_CP032543.1 Lanthipeptides: D6270_RS22715_lanthipeptideNZ_CP076457.1 Lanthipeptides: KME66_RS09945_lanthipeptideNZ_CP077652.1 Lanthipeptides: KRR37_RS22855_lanthipeptideNZ_WUEJ01000001.1 Lanthipeptides: GRQ63_RS04560_lanthipeptide

Lanthipeptides: BHQ08_RS03045_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSV LCTP

1

GSQVSLLVCEYSSLSVTLCTP

21

95.2%

NZ_CP010519.1and 1 other:

NZ_CP092644.1 Lanthipeptides: MID12_RS21330_lanthipeptide

Lanthipeptides: SLNWT_RS22370_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSVVLC+P

1

GSQVSLLVCEYSSLSVVLCSP

21

with 77 more sequence matches

Only the first 10 are displayed here.

95.2%

NZ_CP045178.1:

Lanthipeptides: GBW32_RS28450_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CEYSSLSVVLCTP

1

GSQVSLLICEYSSLSVVLCTP

21

95.2%

NZ_CP054926.1and 11 others:

NZ_CP068598.1 Lanthipeptides: IFE09_RS23820_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS23495_lanthipeptideNZ_CP080029.1 Lanthipeptides: KZO11_RS24935_lanthipeptideNZ_JAJUKK010000008.1 Lanthipeptides: LXH09_RS27635_lanthipeptideNZ_JOJC01000009.1 Lanthipeptides: IO23_RS0108435_lanthipeptideNZ_KB891296.1 Lanthipeptides: B061_RS0103425_lanthipeptideNZ_KZ268499.1 Lanthipeptides: CE422_RS23450_lanthipeptideNZ_KZ819159.1 Lanthipeptides: DBP19_RS22830_lanthipeptideNZ_LR881952.1 Lanthipeptides: STRPST75_RS10975_lanthipeptideNZ_LZQS01000001.1 Lanthipeptides: STIB_RS05225_lanthipeptideNZ_RCOL01000001.1 Lanthipeptides: STAN_RS24840_lanthipeptide

Lanthipeptides: HUT09_RS23550_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCE+SSLSVVLCTP

1

GSQVSLLVCEFSSLSVVLCTP

21

95.2%

NZ_CP058556.1and 5 others:

NZ_CP059898.1 Lanthipeptides: H3V39_RS22935_lanthipeptideNZ_CP070242.1 Lanthipeptides: I6J39_RS23755_lanthipeptideNZ_CP070260.1 Lanthipeptides: I6J40_RS10935_lanthipeptideNZ_JAJDST010000047.1 Lanthipeptides: LJC81_RS16960_lanthipeptideNZ_WWGL01000003.1 Lanthipeptides: GTY38_RS03410_lanthipeptide

Lanthipeptides: HXS80_RS11105_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVS+LVCEYSSLSVVLCTP

1

GSQVSVLVCEYSSLSVVLCTP

21

90.5%

NZ_CM001165.1and 4 others:

NZ_CP021118.1 Lanthipeptides: CAC01_RS28155_lanthipeptideNZ_CP049945.1 Lanthipeptides: G9U55_RS17850_lanthipeptideNZ_CP119149.1 Lanthipeptides: P0D76_RS02270_lanthipeptideNZ_RWGV01000033.1 Lanthipeptides: EJA11_RS20985_lanthipeptide

Lanthipeptides: STTU_RS29395_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CEYSSLSV LCTP

1

GSQVSLLICEYSSLSVTLCTP

21

85.7%

NC_020990.1and 26 others:

NZ_AMPN02000002.1 Lanthipeptides: SM8_RS12785_lanthipeptideNZ_AP025692.1 Lanthipeptides: MTP06_RS18190_lanthipeptideNZ_CM002273.1 Lanthipeptides: B590_RS12280_lanthipeptideNZ_CP009802.1 Lanthipeptides: SFR_RS12925_lanthipeptideNZ_CP014485.1 Lanthipeptides: Salbus254_RS12710_lanthipeptideNZ_CP016824.1 Lanthipeptides: BEN82_RS18165_lanthipeptideNZ_CP026490.1 Lanthipeptides: C3K23_RS19520_lanthipeptideNZ_CP031742.1 Lanthipeptides: D0C37_RS13445_lanthipeptideNZ_CP047147.1 Lanthipeptides: GR131_RS18520_lanthipeptideNZ_CP053539.1 Lanthipeptides: HN026_RS11800_lanthipeptideNZ_CP056773.1 Lanthipeptides: HWN34_RS12245_lanthipeptideNZ_CP063844.1 Lanthipeptides: IPZ55_RS12410_lanthipeptideNZ_CP064783.1 Lanthipeptides: IT782_RS12060_lanthipeptideNZ_CP076385.1 Lanthipeptides: KNZ81_RS12450_lanthipeptideNZ_CP079112.1 Lanthipeptides: STALF2_RS18135_lanthipeptideNZ_CP091820.1 Lanthipeptides: L2I08_RS02835_lanthipeptideNZ_CP106650.1 Lanthipeptides: B591_RS12385_lanthipeptideNZ_CP113103.1 Lanthipeptides: OSU72_RS17905_lanthipeptideNZ_JAHUVY010000001.1 Lanthipeptides: STALF3_RS17905_lanthipeptideNZ_JALLPQ010000001.1 Lanthipeptides: MWG58_RS12385_lanthipeptideNZ_KB890715.1 Lanthipeptides: B048_RS0115750_lanthipeptideNZ_KN549183.1 Lanthipeptides: D076_RS30740_lanthipeptideNZ_KZ195583.1 Lanthipeptides: B9W68_RS12440_lanthipeptideNZ_MNPQ01000004.1 Lanthipeptides: BGV78_RS11170_lanthipeptideNZ_OX371412.1 Lanthipeptides: OZE77_RS18215_lanthipeptideNZ_VOGX01000092.1 Lanthipeptides: FRZ02_RS31600_lanthipeptide

Lanthipeptides: XNR_RS11575_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQ+SLL+CEYSSLSV LCTP

1

GSQISLLICEYSSLSVTLCTP

21

85.7%

NZ_AQRJ01000051.1and 1 other:

NZ_LFBV01000002.1 Lanthipeptides: AB852_RS09920_lanthipeptide

Lanthipeptides: YW7_RS14945_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSL+VCEYSSLS +LCTP

1

GSQVSLIVCEYSSLSALLCTP

21

85.7%

NZ_CP045702.1:

Lanthipeptides: F0344_RS33200_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCE+SSLS+ LCTP

1

GSQVSLLVCEHSSLSLTLCTP

21

85.7%

NZ_ML123034.1:

Lanthipeptides: EES43_RS19795_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CE+SSLSV LCTP

1

GSQVSLLICEFSSLSVTLCTP

21

81.0%

NZ_LWLE01000019.1:

Lanthipeptides: A6A29_RS44250_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CE+SSLS+ LCTP

1

GSQVSLLICEHSSLSLTLCTP

21

61.9%

NZ_QGGR01000008.1:

Lanthipeptides: BC793_RS19230_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCT

20

GSQ SLL+C SSLSV C

2

GSQASLLLCGDSSLSVTTCN

21

MIBiG 4.0 matches for DBP20_RS23960

95.5%

Lanthipeptide: SRO15-2212

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSVVLCTP

2

GSQVSLLVCEYSSLSVVLCTP

22

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.51 out of 25.31

Confidence: medium

Additional weak hits (7):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.97 out of 21.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.34 out of 27.78

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 25.75

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.91 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.37 out of 29.38

Confidence: weak

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

DBP20_RS23960 - Class III

Cleavage pHMM score: 31.80

RODEO score: 0

Monoisotopic mass: 2075.1 Da

Molecular weight: 2076.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2094.4 Da N = 1; 2112.4 Da N = 2; 2130.5 Da N = 3; 2148.5 Da N = 4

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
IolR	Regulator of the inositol catabolism

NZ_KZ819178.1 - Region 22 - terpene-precursor

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Location: 5,413,945 - 5,434,988 nt. (total: 21,044 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: dehydratase

DBP20_RS24690: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase

DBP20_RS24655: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000673.3	0.53	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000678.5	0.35	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000664.5	0.35	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000644.3	0.34	terpene	carotenoid	Dietzia sp. CQ4
BGC0000668.5	0.34	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000673.3	0.53	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000678.5	0.35	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000664.5	0.35	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000644.3	0.34	terpene	carotenoid	Dietzia sp. CQ4
BGC0000668.5	0.34	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

DBP20_RS24655: PT_FPPS_like

Domain 1 (59 - 345): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.77 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.90 out of 20.47

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.21 out of 23.79

Confidence: medium

Additional weak hits (6):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.69 out of 20.97

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.67 out of 24.78

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.28 out of 23.43

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.99 out of 27.55

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.43 out of 35.63

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.57 out of 30.98

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 23 - ectoine,t3nrps-iterative

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Location: 5,497,077 - 5,549,463 nt. (total: 52,387 nt) Show pHMM detection rules used

t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DBP20_RS25095: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Hydrolases: hydrolase

DBP20_RS25110: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: decarboxylase

DBP20_RS25140: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Isomerases: isomerase

DBP20_RS25060: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

DBP20_RS25080: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS25150: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000307.4	0.53	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.52	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.52	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002135.2	0.52	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.52	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.51	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002164.2	0.50	NRPS	peramine	Epichloe festucae
BGC0001641.4	0.50	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.49	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.49	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002135.2	0.59	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000883.5	0.59	other (other)	arginomycin	Streptomyces arginensis
BGC0002164.2	0.59	NRPS	peramine	Epichloe festucae
BGC0001641.4	0.58	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.58	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.61 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.70 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.67 out of 19.26

Confidence: medium

Additional weak hits (12):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.04 out of 23.43

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.35 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.79 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.18 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.95 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.75 out of 29.38

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.65 out of 27.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.61 out of 27.78

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.33 out of 33.14

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.93 out of 24.78

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.55 out of 35.63

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

DBP20_RS25080: X

AMP-binding (13..389): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FWAAFDLALLDTQGVTTGEHNVFGCTETNDSFIH
Nearest Stachelhaus code(s):: Gly DILQVGVIWK (35% 8Å match)
Stachelhaus code match:: 60% (weak)

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism

NZ_KZ819178.1 - Region 24 - terpene

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Location: 5,646,216 - 5,667,193 nt. (total: 20,978 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase hydrolase

DBP20_RS25660: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

DBP20_RS25675: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: cyclase hydratase

DBP20_RS25645: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

DBP20_RS25680: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002196.2	0.30	PKS	clavatol	Penicillium crustosum
BGC0000913.3	0.29	other (other)	MK-8	Enterobacter cloacae
BGC0002553.2	0.29	other (other)	tunicamycin	Rathayibacter iranicus
BGC0001866.4	0.29	PKS	viriditoxin	Byssochlamys spectabilis
BGC0002034.3	0.28	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000252.5	0.28	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000518.3	0.28	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000875.4	0.28	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0000157.5	0.28	PKS	tautomycetin	Streptomyces sp. CK4412
BGC0000243.4	0.27	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002196.2	0.30	PKS	clavatol	Penicillium crustosum
BGC0000913.3	0.29	other (other)	MK-8	Enterobacter cloacae
BGC0002553.2	0.29	other (other)	tunicamycin	Rathayibacter iranicus
BGC0001866.4	0.29	PKS	viriditoxin	Byssochlamys spectabilis
BGC0002034.3	0.28	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000252.5	0.28	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000518.3	0.28	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000875.4	0.28	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0000157.5	0.28	PKS	tautomycetin	Streptomyces sp. CK4412
BGC0000243.4	0.27	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

DBP20_RS25680: T1TS

Domain 1 (1 - 305): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.85 out of 27.78

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

Additional weak hits (15):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.05 out of 30.22

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 15.99 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.08 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.75 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.11 out of 27.78

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.68 out of 27.04

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.51 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.24 out of 31.73

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.24 out of 27.55

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.52 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.90 out of 28.19

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.14 out of 32.93

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 25 - NI-siderophore

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Location: 6,060,913 - 6,093,677 nt. (total: 32,765 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

DBP20_RS27500: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: aminotransferase

DBP20_RS27450: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Isomerases: mutase

DBP20_RS27505: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.54	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002683.2	0.51	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001531.5	0.51	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002633.2	0.50	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002470.2	0.50	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.54	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002683.2	0.51	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001531.5	0.51	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002633.2	0.50	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002470.2	0.50	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 24.62 out of 27.18

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.93 out of 24.78

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 24.17 out of 27.18

Confidence: medium

Additional weak hits (10):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.39 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.25 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.98 out of 29.38

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.88 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.09 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.77 out of 25.88

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.32 out of 23.43

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.88 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
LexA variant 2	Repressor of DNA damage response
NrdR	Represses ribonucleotide reductase encoding genes
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 26 - hydrogen-cyanide

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Location: 6,171,448 - 6,184,396 nt. (total: 12,949 nt) Show pHMM detection rules used

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

DBP20_RS27865: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

DBP20_RS27870: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

DBP20_RS27880: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Hydrolases: deaminase

DBP20_RS27900: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0002285.2	0.33	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000595.3	0.29	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000135.5	0.23	PKS	reveromycin A	Streptomyces sp. SN-593
BGC0000378.5	0.21	NRPS	Kutzneride 1, Kutzneride 2, Kutzneride 3, Kutzneride 4, Kutzneride 5, Kutzneride 6, Kutzneride 7, Kutzneride 8	Kutzneria sp. 744

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0002285.2	0.33	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000595.3	0.29	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000135.5	0.23	PKS	reveromycin A	Streptomyces sp. SN-593
BGC0000378.5	0.21	NRPS	Kutzneride 1, Kutzneride 2, Kutzneride 3, Kutzneride 4, Kutzneride 5, Kutzneride 6, Kutzneride 7, Kutzneride 8	Kutzneria sp. 744

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 22.40

Confidence: strong

Additional weak hits (4):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.93 out of 39.62

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.19 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.35 out of 33.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 20.42 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
HypR	L-hydroxyproline utilization repressor

NZ_KZ819178.1 - Region 27 - lanthipeptide-class-i

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Location: 6,298,880 - 6,325,328 nt. (total: 26,449 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

DBP20_RS28460: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

DBP20_RS28465: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.44	ribosomal	penisin	Paenibacillus ehimensis
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.44	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000544.4	0.40	ribosomal	planosporicin	Planomonospora alba
BGC0002120.3	0.38	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000529.5	0.36	ribosomal	microbisporicin A2	Microbispora corallina
BGC0001414.5	0.36	NRPS	griselimycin	Streptomyces muensis
BGC0000503.5	0.34	ribosomal	cinnamycin	Streptomyces cinnamoneus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.44	ribosomal	penisin	Paenibacillus ehimensis
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.44	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000544.4	0.40	ribosomal	planosporicin	Planomonospora alba
BGC0002120.3	0.38	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706
BGC0000529.5	0.36	ribosomal	microbisporicin A2	Microbispora corallina
BGC0001414.5	0.36	NRPS	griselimycin	Streptomyces muensis
BGC0000503.5	0.34	ribosomal	cinnamycin	Streptomyces cinnamoneus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.25 out of 29.72

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.58 out of 23.05

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.13 out of 20.47

Confidence: medium

Additional weak hits (2):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.29 out of 29.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.85 out of 28.19

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 163 - 255; Score: 65.4

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
AfsR	Pleiotropic regulatory for antibiotic production
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 28 - RiPP-like

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Location: 6,434,021 - 6,445,349 nt. (total: 11,329 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002298.2	0.34	ribosomal	lassomycin-like peptide	Sanguibacter keddieii DSM 10542
BGC0000496.5	0.33	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000306.5	0.32	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0000565.5	0.31	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0002303.3	0.27	ribosomal	pristinin A3	Streptomyces pristinaespiralis
BGC0002387.2	0.27	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0002126.3	0.27	NRPS	hypeptin	Lysobacter sp. K5869
BGC0000461.5	0.27	NRPS	WAP-8294A2	Lysobacter enzymogenes
BGC0002115.3	0.26	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001377.5	0.26	PKS	uncialamycin	Streptomyces uncialis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002298.2	0.34	ribosomal	lassomycin-like peptide	Sanguibacter keddieii DSM 10542
BGC0000496.5	0.33	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000306.5	0.32	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0000565.5	0.31	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0002303.3	0.27	ribosomal	pristinin A3	Streptomyces pristinaespiralis
BGC0002387.2	0.27	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0002126.3	0.27	NRPS	hypeptin	Lysobacter sp. K5869
BGC0000461.5	0.27	NRPS	WAP-8294A2	Lysobacter enzymogenes
BGC0002115.3	0.26	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001377.5	0.26	PKS	uncialamycin	Streptomyces uncialis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.74 out of 26.85

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.30 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_KZ819178.1 - Region 29 - NRPS

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Location: 6,457,820 - 6,501,110 nt. (total: 43,291 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase reductase

DBP20_RS29195: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

DBP20_RS29230: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

DBP20_RS29265: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS29300: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: methyltransferase

DBP20_RS29295: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: esterase

DBP20_RS29185: thioesterase

smcogs: SMCOG1004: thioesterase

DBP20_RS29225: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

DBP20_RS29180: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS29215: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS29245: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS29290: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000373.5	0.86	NRPS	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.65	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0000307.4	0.62	NRPS	AbT1	Aureobasidium pullulans
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000373.5	0.86	NRPS	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001132.4	0.65	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.65	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0000307.4	0.62	NRPS	AbT1	Aureobasidium pullulans
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.15 out of 20.97

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

Additional weak hits (7):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.92 out of 23.43

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 17.85 out of 25.88

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.84 out of 30.25

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.82 out of 27.55

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.73 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.41 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 40, location 6457819 - 6501110:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS29215: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (503..907): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDIAFDLSVYDGNSLLSGDISLGGATEGSIWSVC
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

DBP20_RS29245: X

AMP-binding (19..376): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ESFGFSL-VGGHLGVSGGEGQAYGTTESGVVAAD
Nearest Stachelhaus code(s):: nohBza GLGLVGAIIK (68% 8Å match); Leu DALLVGAVVK (41% 8Å match)
Stachelhaus code match:: 70% (weak)

DBP20_RS29290: X

AMP-binding (63..450): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FGKLHSAGISYLLGNGMGDVDGLGSSEMGMVLFR
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 30 - terpene

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Location: 6,688,267 - 6,709,577 nt. (total: 21,311 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

DBP20_RS30145: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

DBP20_RS30215: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase

DBP20_RS30190: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

DBP20_RS30195: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: cyclase

DBP20_RS30185: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000658.3	0.87	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000659.3	0.79	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000657.5	0.64	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000866.5	0.49	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000671.3	0.41	terpene	momilactone B	Oryza sativa Japonica Group
BGC0001590.5	0.41	PKS	formicamycin A, formicamycin B, formicamycin C, formicamycin D, formicamycin E, formicamycin F, formicamycin G, formicamycin H, formicamycin I, formicamycin J, formicamycin K, formicamycin L, formicamycin M, fasamycin C, fasamycin D, fasamycin E	Streptomyces sp. KY5
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001526.4	0.40	other (other)	bartoloside E, bartoloside F, bartoloside G, bartoloside H, bartoloside I, bartoloside J, bartoloside K	Synechocystis salina LEGE 06099
BGC0001525.3	0.40	other (other)	bartoloside B, bartoloside C, bartoloside D	Synechocystis salina LEGE 06155

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000658.3	0.87	terpene	2-methylisoborneol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000659.3	0.79	terpene	2-methylisoborneol	Saccharopolyspora erythraea NRRL 2338
BGC0000657.5	0.64	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000866.5	0.49	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000671.3	0.41	terpene	momilactone B	Oryza sativa Japonica Group
BGC0001590.5	0.41	PKS	formicamycin A, formicamycin B, formicamycin C, formicamycin D, formicamycin E, formicamycin F, formicamycin G, formicamycin H, formicamycin I, formicamycin J, formicamycin K, formicamycin L, formicamycin M, fasamycin C, fasamycin D, fasamycin E	Streptomyces sp. KY5
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001526.4	0.40	other (other)	bartoloside E, bartoloside F, bartoloside G, bartoloside H, bartoloside I, bartoloside J, bartoloside K	Synechocystis salina LEGE 06099
BGC0001525.3	0.40	other (other)	bartoloside B, bartoloside C, bartoloside D	Synechocystis salina LEGE 06155

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
monoterpene		2-methylisoborneol	C11	C1-C6	OH
monoterpene		2-methylenebornane	C11	C1-C6	none

Genes with terpene domains:

DBP20_RS30185: T1TS

Domain 1 (11 - 430): Type 1 terpene synthase

Subtype: 2-Methylisoborneol synthase type

Reactions:: 2-MeGPP → 2-methylisoborneol; 2-MeGPP → 2-methylenebornane

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

Additional weak hits (4):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.11 out of 18.57

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.60 out of 26.85

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.26 out of 28.19

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.87 out of 23.43

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
2-MeGPP	2-methylgeranyl diphosphate

TFBS definitions

Regulator	Description
RpoN	Regulator of nitrogen assimilation and virulence

NZ_KZ819178.1 - Region 31 - NRPS,NRPS-like,PKS-like

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Location: 6,877,284 - 6,956,733 nt. (total: 79,450 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

DBP20_RS30970: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

DBP20_RS31050: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DBP20_RS31100: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS31115: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: kinase

DBP20_RS31150: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: esterase

DBP20_RS31045: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

DBP20_RS31035: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

DBP20_RS31040: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS31055: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS31060: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS31070: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS31080: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS31085: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DBP20_RS31105: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	1.31	NRPS	enniatin	Fusarium equiseti
BGC0001249.5	1.28	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	1.27	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	1.25	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	1.24	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	1.21	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001261.3	1.20	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	1.19	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	1.19	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758.4	1.13	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.78	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.78	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.78	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.78	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.77	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.76	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000342.4	0.76	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.76	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.75	NRPS	AM-toxin	Alternaria alternata
BGC0001249.5	0.75	NRPS	dimethylcoprogen	Alternaria alternata

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.33 out of 19.52

Confidence: strong

Additional weak hits (7):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.56 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.82 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.35 out of 30.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.42 out of 18.57

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.11 out of 33.73

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.45 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 19.95 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 42, location 6877283 - 6956733:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NH2 - Gly) + (Pro - X) + (X) + (NMe-X) + (Val) + (D-Ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 43, location 6877283 - 6918312:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Ala) + (Val) + (NMe-X) + (X) + (Pro - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 44, location 6878413 - 6920237:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Ala) + (Val) + (NMe-X) + (X) + (Pro - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 45, location 6884606 - 6956733:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NH2 - Gly) + (Pro - X) + (X) + (NMe-X) + (Val) + (D-Ala)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS31040: D-Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (30..422): D-Ala

nrpys: D-Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: LALTFDMAVPELQALCGGEWNMYGPTETTVWSVS
Nearest Stachelhaus code(s):: D-Ala DMPQLGMVWK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

DBP20_RS31055: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (188..581): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LEPAFDASTLEAWMLAGGDTNGYGPTENTTFTTC
Nearest Stachelhaus code(s):: Val DALWLGGTFK (88% 8Å match); bOH-Val DALWLGGTFK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

DBP20_RS31060: X

AMP-binding (503..886): X

nrpys: Ser, Thr, Dhpg, Hpg

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RSAVFDLGPWEWGCVCAGERS--GPAHMALDVIV
Nearest Stachelhaus code(s):: nDece DFWGVAGMSK (29% 8Å match)
Stachelhaus code match:: 60% (weak)

DBP20_RS31070: X

AMP-binding (463..882): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: NDLSFDMSVYEGNSFLGGDIVMGGATEASIHSIL
Nearest Stachelhaus code(s):: Lys DMYNFGLIHK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

DBP20_RS31080: X - Orn - Pro - X

Search NORINE for peptide: strict or relaxed

AMP-binding (476..863): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FGTTFDVSVYEVLSSIGGEQNGYGPAETTVEASC
Nearest Stachelhaus code(s):: Lys DVFESGGVAK (62% 8Å match); Cyc-D-Gly DAYLWGGVFK (56% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (963..1364): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: LSHAFDASWCGWDVLLGGEFNLYGPTECTVDMLV
Nearest Stachelhaus code(s):: Arg DADDVGLVDK (71% 8Å match); Ile DAQDLGVVDK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2015..2393): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDVFAQESFAVQAGEHNHYGPTETHVVTTY
Nearest Stachelhaus code(s):: Pro DVQFVAHVVK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3034..3421): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FWQGHDPFLREGHLFFGGDVNFYGTTETPQAVSW
Nearest Stachelhaus code(s):: Aad DPRHFVMRAK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

DBP20_RS31105: NH2 - Gly

Search NORINE for peptide: strict or relaxed

CAL_domain (34..443): NH2

minowa: NH2

Prediction, score:

NH2: 147.9
Acetyl-CoA: 26.1
AHBA: 19.9
fatty_acid: 15.1
shikimic_acid: 0.0

AMP-binding (1108..1499): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDISVLELQAITGGELNMYGPTETTVWSAS
Nearest Stachelhaus code(s):: Gly DILQIGMVWK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_KZ819178.1 - Region 32 - terpene

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Location: 7,101,951 - 7,128,524 nt. (total: 26,574 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DBP20_RS31825: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

DBP20_RS31860: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: aminotransferase transferase

DBP20_RS31820: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

DBP20_RS31885: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Lyases: dehydratase

DBP20_RS31810: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase

DBP20_RS31865: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.69	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002508.2	0.48	other (other)	8-azaguanine	Streptomyces pathocidini
BGC0000644.3	0.47	terpene	carotenoid	Dietzia sp. CQ4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.69	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0002508.2	0.48	other (other)	8-azaguanine	Streptomyces pathocidini
BGC0000644.3	0.47	terpene	carotenoid	Dietzia sp. CQ4

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

DBP20_RS31850: PT_phytoene_like

Domain 1 (16 - 285): Prenyltransferase; Phytoene synthase like

Subtype: Hydroxysqualene synthase

Reactions:: PSPP → hydroxysqualene

DBP20_RS31855: PT_phytoene_like

Domain 1 (13 - 296): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → PSPP; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

DBP20_RS31865: PT_FPPS_like

Domain 1 (72 - 366): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

DBP20_RS31870: T2TS

Domain 1 (28 - 654): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46

Confidence: medium

Additional weak hits (8):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.59 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.50 out of 30.22

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.72 out of 36.54

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.37 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.12 out of 26.06

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.38 out of 26.85

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.72 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
MexT	Global virulence regulator
RpoN	Regulator of nitrogen assimilation and virulence

NZ_KZ819178.1 - Region 33 - NRPS,T1PKS

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Location: 7,188,287 - 7,237,694 nt. (total: 49,408 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

DBP20_RS32215: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS32240: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

DBP20_RS32300: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

DBP20_RS32305: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

DBP20_RS32310: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

DBP20_RS32315: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DBP20_RS32365: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

DBP20_RS32375: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

DBP20_RS32380: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase

DBP20_RS32285: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Isomerases: racemase

DBP20_RS32320: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: synthase

DBP20_RS32295: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transport

DBP20_RS32255: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001043.4	1.15	NRPS, PKS	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365.2	1.09	PKS, other (other)	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001273.3	0.90	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.90	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.90	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000996.5	0.88	NRPS, PKS	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001726.4	0.65	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001043.4	0.83	NRPS, PKS	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365.2	0.81	PKS, other (other)	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000996.5	0.75	NRPS, PKS	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001726.4	0.66	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 25.17 out of 29.51

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.38 out of 19.26

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 28.35 out of 35.63

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 30.52 out of 35.63

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.09 out of 20.47

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.23 out of 27.04

Confidence: medium

Additional weak hits (8):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.47 out of 21.55

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.82 out of 25.88

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.12 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.36 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.61 out of 21.55

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.91 out of 19.26

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.18 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.01 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 47, location 7188286 - 7237694:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - Orn)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS32295: pk - Orn

Search NORINE for peptide: strict or relaxed

PKS_AT (549..845): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; CE-Malonyl-CoA: 54.2%; Acetyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 126.1
Methoxymalonyl-CoA: 118.9
Malonyl-CoA: 116.9
Ethylmalonyl-CoA: 104.9
Isobutyryl-CoA: 85.9
Propionyl-CoA: 74.9
2-Methylbutyryl-CoA: 71.6
trans-1,2-CPDA: 70.6
Acetyl-CoA: 66.8
Benzoyl-CoA: 57.7
CHC-CoA: 52.9
fatty_acid: 48.7
3-Methylbutyryl-CoA: 39.3
inactive: 35.9

AMP-binding (2301..2722): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: AAWAFDVFTGDREFVVGSDVNSYGLTEATIDSAY
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
DasR	N-acetylglucosamine dependent repressor
DosR	Hypoxia stress response regulator
NrtR	NAD synthesis repressor
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 34 - RiPP-like

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Location: 7,264,796 - 7,275,593 nt. (total: 10,798 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DBP20_RS32540: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Lyases: decarboxylase

DBP20_RS32525: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.5	0.37	other (other)	showdomycin	Streptomyces showdoensis
BGC0001575.4	0.34	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001891.3	0.32	other (other)	closthioamide	Ruminiclostridium cellulolyticum H10
BGC0001285.5	0.32	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001882.3	0.31	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000728.5	0.31	saccharide	capsular polysaccharide	Klebsiella pneumoniae subsp. ozaenae
BGC0000729.3	0.31	saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000975.5	0.30	NRPS, PKS	Cryptophycin A	Nostoc sp. ATCC 53789
BGC0000791.3	0.30	saccharide	O-antigen	Cronobacter sakazakii
BGC0000732.3	0.28	saccharide	capsular polysaccharide	Raoultella planticola

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.5	0.37	other (other)	showdomycin	Streptomyces showdoensis
BGC0001575.4	0.34	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001891.3	0.32	other (other)	closthioamide	Ruminiclostridium cellulolyticum H10
BGC0001285.5	0.32	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001882.3	0.31	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000728.5	0.31	saccharide	capsular polysaccharide	Klebsiella pneumoniae subsp. ozaenae
BGC0000729.3	0.31	saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000975.5	0.30	NRPS, PKS	Cryptophycin A	Nostoc sp. ATCC 53789
BGC0000791.3	0.30	saccharide	O-antigen	Cronobacter sakazakii
BGC0000732.3	0.28	saccharide	capsular polysaccharide	Raoultella planticola

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.00 out of 20.47

Confidence: medium

Additional weak hits (1):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 35 - NRPS,T1PKS,terpene

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Location: 7,421,098 - 7,483,858 nt. (total: 62,761 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DBP20_RS33240: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: methyltransferase

DBP20_RS33260: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

DBP20_RS33345: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Ligases: ligase synthase synthetase

DBP20_RS33235: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

DBP20_RS33335: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

DBP20_RS33340: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	1.21	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.96	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.88	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.83	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.82	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000342.4	0.60	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001273.3	0.59	PKS	asperlactone	Aspergillus ochraceus
BGC0000307.4	0.59	NRPS	AbT1	Aureobasidium pullulans
BGC0002135.2	0.59	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.85	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.79	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.75	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.71	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.71	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000342.4	0.64	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

DBP20_RS33235: PT_FPPS_like

Domain 1 (7 - 280): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

DBP20_RS33245: PT_phytoene_like

Domain 1 (16 - 322): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → PSPP; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

DBP20_RS33265: Lycopene_cycl

Domain 1 (9 - 386): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.26 out of 23.79

Confidence: medium

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 24.74 out of 29.65

Confidence: medium

Additional weak hits (11):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.76 out of 29.38

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.07 out of 33.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.43 out of 31.73

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 17.77 out of 36.54

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.28 out of 26.33

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.04 out of 19.26

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.96 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.93 out of 29.38

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.77 out of 21.55

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.46 out of 24.78

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 49, location 7421097 - 7483858:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 51, location 7433206 - 7483858:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS33335: mal

PKS_AT (548..841): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 129.0
inactive: 69.8
Methylmalonyl-CoA: 65.7
Methoxymalonyl-CoA: 54.1
Propionyl-CoA: 36.5
Isobutyryl-CoA: 35.0
Ethylmalonyl-CoA: 32.2
trans-1,2-CPDA: 22.8
Acetyl-CoA: 18.0
3-Methylbutyryl-CoA: 17.4
fatty_acid: 16.5
2-Methylbutyryl-CoA: 14.9
Benzoyl-CoA: 13.5
CHC-CoA: 11.4

DBP20_RS33340: X

AMP-binding (1408..1808): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWHCFDASLLEPVLLLGGEVNVYGPTETTVLCLT
Nearest Stachelhaus code(s):: aIle DALVFGVVLK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
IolR	Regulator of the inositol catabolism
LexA variant 1	Repressor of DNA damage response

NZ_KZ819178.1 - Region 36 - RiPP-like

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Location: 7,505,168 - 7,516,535 nt. (total: 11,368 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.77	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001579.4	0.40	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002531.3	0.39	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0000571.3	0.37	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002073.3	0.37	NRPS	dehydroxynocardamine	Corynebacterium propinquum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.77	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001579.4	0.40	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002531.3	0.39	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0000571.3	0.37	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002073.3	0.37	NRPS	dehydroxynocardamine	Corynebacterium propinquum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 17.84 out of 23.79

Confidence: medium

Additional weak hits (2):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 19.44 out of 30.98

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.28 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_KZ819178.1 - Region 37 - azole-containing-RiPP,melanin,terpene-precursor

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Location: 7,517,176 - 7,566,430 nt. (total: 49,255 nt) Show pHMM detection rules used

melanin: melC
terpene-precursor: (PT_FPPS_like and not PT_HPP)
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

DBP20_RS33570: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DBP20_RS33665: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

DBP20_RS33690: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

DBP20_RS33695: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

DBP20_RS33700: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: glycosyltransferase

DBP20_RS33600: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

DBP20_RS33620: sugar transferase

smcogs: SMCOG1146: sugar transferase

DBP20_RS33625: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Lyases: dehydratase

DBP20_RS33720: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Ligases: synthetase

DBP20_RS33630: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000911.3	0.63	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3	0.51	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000909.3	0.30	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.26	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001435.4	0.25	NRPS, PKS	ikarugamycin	Streptomyces sp. ZJ306
BGC0000800.5	0.25	saccharide	xanthan	Xanthomonas campestris
BGC0002220.2	0.24	terpene	Ent-kauren-16alpha-ol	Punctularia strigosozonata HHB-11173 SS5
BGC0002707.2	0.23	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0001529.5	0.22	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0000606.5	0.21	ribosomal	lactazole	Streptomyces lactacystinaeus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000911.3	0.85	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3	0.79	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000909.3	0.64	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.59	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000606.5	0.58	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001146.5	0.54	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0002397.2	0.53	terpene	astallatene	Arabidopsis thaliana
BGC0000908.3	0.52	other (other)	melanin	Streptomyces avermitilis
BGC0001145.5	0.51	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0002400.2	0.49	terpene	boleracene	Brassica oleracea var. oleracea

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

DBP20_RS33630: PT_FPPS_like

Domain 1 (57 - 340): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.44 out of 20.97

Confidence: medium

Additional weak hits (6):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.17 out of 20.97

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 15.53 out of 21.84

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.61 out of 26.85

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.78 out of 32.74

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.13 out of 30.97

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.97 out of 30.98

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

Terpene

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Thiopeptide_F_RRE; Location: 31 - 119; Score: 43.8

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A

Core peptide predictions

No core peptides found.

NZ_KZ819178.1 - Region 38 - NRPS,T3PKS

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Location: 7,566,872 - 7,673,060 nt. (total: 106,189 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

DBP20_RS33890: oxidoreductase

smcogs: SMCOG1161: oxidoreductase

DBP20_RS34030: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: kinase methyltransferase

DBP20_RS33885: Methylation

MITE: MITE0000155Methylation (identity: 90.80%)
smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

DBP20_RS34025: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: hydrolase

DBP20_RS33995: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase synthase

DBP20_RS33880: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

DBP20_RS33930: carboxylate-amine ligase

smcogs: SMCOG1165: carboxylate-amine ligase

DBP20_RS33970: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS33975: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS33980: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Translocases: transporter

DBP20_RS34045: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	1.38	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.45	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002135.2	0.43	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.41	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.41	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001133.4	0.40	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.39	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.38	NRPS	HC-toxin	Alternaria jesenskae
BGC0001825.4	0.37	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001240.4	0.37	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.88	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001133.4	0.72	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001240.4	0.70	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.20 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.19 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.73 out of 36.53

Confidence: medium

Additional weak hits (16):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.41 out of 26.85

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.44 out of 32.74

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.63 out of 18.57

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.53 out of 21.55

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.66 out of 33.14

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.27 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.90 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.81 out of 29.65

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 20.95 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.54 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.56 out of 26.06

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.57 out of 36.53

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.62 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 28.19 out of 39.62

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.65 out of 29.65

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.02 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 57, location 7566871 - 7673060:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Gly - Thr - Ser - D-X) + (Thr - D-His - Val - D-X) + (D-X - Gly - D-Ser - OH-Orn)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 58, location 7566871 - 7607924:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Gly - Thr - Ser - D-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 59, location 7584705 - 7673060:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Gly - Thr - Ser - D-X) + (Thr - D-His - Val - D-X) + (D-X - Gly - D-Ser - OH-Orn)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS33970: Gly - Gly - Thr - Ser - X

Search NORINE for peptide: strict or relaxed

AMP-binding (478..882): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: LAMTFDIAALEVQALSGGEVNVYGPTETTIWSTA
Nearest Stachelhaus code(s):: Gly DILQLGVIWK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1566..1960): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FCLTFDIAVLELQALAGGEVNLYGPTETTIWSTA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2612..3024): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVLGGEVNMYGITETTVHVTT
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3680..4078): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWATFDVSVWEWHFLASGEHNLYGPTEAAVDVTA
Nearest Stachelhaus code(s):: Ser DVWHLSLVDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4727..5110): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LAQAFDASVMEMLIIVGGEVNAYGPTEATACVTM
Nearest Stachelhaus code(s):: Leu DAMLVGAACK (91% 8Å match)
Stachelhaus code match:: 90% (moderate)

DBP20_RS33975: Thr - His - Val - X

Search NORINE for peptide: strict or relaxed

AMP-binding (481..900): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEVNMYGITETTVHVTH
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1562..1960): His

nrpys: His

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTLAFDTSVWEMTVIVAGEFNSYGPTETTVDATL
Nearest Stachelhaus code(s):: His DTWTIASVDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3057..3459): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDSSFDAATHEGWFWTGGDVNGYGPTETTTFATA
Nearest Stachelhaus code(s):: Val DAYWWGGTFK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (4126..4522): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RWTAFDVSVWEGHFFSGGEVNQYGPTEAAVDVTA
Nearest Stachelhaus code(s):: His DYWHFGAVDK (82% 8Å match); Ser DVWHFSLVDK (79% 8Å match)
Stachelhaus code match:: 80% (moderate)

DBP20_RS33980: X - Gly - Ser - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (474..869): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWAAYDVTFCENVIIVGTEFNAYGPTEAVVNSAT
Nearest Stachelhaus code(s):: Fo-OH-Orn DVWIIGAVNK (59% 8Å match); Trp or Pro DVMFIGAVNK (47% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1992..2372): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: LAITFDIAALEVQAMSGGELNLYGPTETTIWSTA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (3032..3432): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFIASGEHNLYGPTEAAIDVTA
Nearest Stachelhaus code(s):: Ser DVWHISLIDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4542..4950): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSHWFDASWQPWEVGVGGEVNLYGPTEGTVDAMV
Nearest Stachelhaus code(s):: OH-Orn DAQEGGLVDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism

NZ_KZ819178.1 - Region 39 - NRPS,T1PKS

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Location: 7,742,132 - 7,794,296 nt. (total: 52,165 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

DBP20_RS34435: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

DBP20_RS34455: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS34535: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: methyltransferase

DBP20_RS34595: methyltransferase

smcogs: SMCOG1089: methyltransferase

Ligases: synthase

DBP20_RS34485: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: transporter

DBP20_RS34420: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000307.4	0.61	NRPS	AbT1	Aureobasidium pullulans
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.60	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.57	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2	0.54	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001160.5	0.53	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.53	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002476.2	0.35	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0001844.4	0.34	NRPS	holrhizin A, holrhizin B, holrhizin C, holrhizin D	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.63	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002476.2	0.49	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0001844.4	0.48	NRPS	holrhizin A, holrhizin B, holrhizin C, holrhizin D	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (14):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.83 out of 26.06

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.30 out of 20.97

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.81 out of 21.84

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.53 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.63 out of 27.78

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.35 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.54 out of 32.74

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.67 out of 21.55

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.20 out of 35.63

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.85 out of 20.01

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.16 out of 24.78

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 60, location 7742131 - 7794296:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NH2 - ohmal - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS34485: NH2 - mal - X

CAL_domain (145..459): NH2

minowa: NH2

Prediction, score:

NH2: 45.2
fatty_acid: 39.3
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

PKS_AT (1214..1496): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 103.8
Methylmalonyl-CoA: 60.3
Methoxymalonyl-CoA: 57.0
inactive: 37.5
fatty_acid: 20.2
Isobutyryl-CoA: 19.6
Ethylmalonyl-CoA: 18.8
Propionyl-CoA: 16.4
Benzoyl-CoA: 12.3
2-Methylbutyryl-CoA: 11.6
trans-1,2-CPDA: 11.1
CHC-CoA: 11.1
Acetyl-CoA: 6.2
3-Methylbutyryl-CoA: 0.0

AMP-binding (2614..3029): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YWAAFDASVRQASSHVGGEANLYGPTEATINTSC
Nearest Stachelhaus code(s):: Gln DACSTGVINK (50% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
VqsM	Regulator of quorum-sensing signalling systems

NZ_KZ819178.1 - Region 40 - T1PKS

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Location: 7,819,818 - 7,968,990 nt. (total: 149,173 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

DBP20_RS34785: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DBP20_RS34790: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DBP20_RS35055: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DBP20_RS36345: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

DBP20_RS36545: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase glycosyltransferase methyltransferase transferase

DBP20_RS34765: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

DBP20_RS34775: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

DBP20_RS34780: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

DBP20_RS34950: methyltransferase

smcogs: SMCOG1248: methyltransferase

Hydrolases: esterase

DBP20_RS34745: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

DBP20_RS34740: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

DBP20_RS34770: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DBP20_RS34860: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS34865: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS35465: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS35475: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS36340: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS36470: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS36550: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DBP20_RS36555: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000151.5	0.80	PKS, saccharide	stambomycin A, stambomycin B, stambomycin C, stambomycin D	Streptomyces ambofaciens ATCC 23877
BGC0001275.3	0.77	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.77	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.3	0.67	PKS	oronofacic acid	Pseudomonas syringae
BGC0000067.5	0.66	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001254.3	0.65	PKS	ACT-Toxin II	Alternaria alternata
BGC0002193.2	0.65	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000151.5	0.80	PKS, saccharide	stambomycin A, stambomycin B, stambomycin C, stambomycin D	Streptomyces ambofaciens ATCC 23877
BGC0001275.3	0.77	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.77	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.3	0.67	PKS	oronofacic acid	Pseudomonas syringae
BGC0000067.5	0.66	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001254.3	0.65	PKS	ACT-Toxin II	Alternaria alternata
BGC0002193.2	0.65	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

Additional weak hits (15):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.24 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.24 out of 29.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.99 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.25 out of 20.97

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.85 out of 18.57

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.26 out of 32.93

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.26 out of 32.93

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.77 out of 32.38

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.30 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.84 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.58 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.50 out of 32.74

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.80 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.72 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 61, location 7819817 - 7968990:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - ccmal - ohmal - ohmal) + (redmal - Me-ohmal) + (redmal - Me-ohmal - Me-ccmal) + (ohmal) + (ohmal - Me-redmal) + (ohmal) + (ohmal - ohmal) + (ohmal - redmal) + (ccmal - Me-ccmal) + (pk - ohmal - Me-ohmal - ohmal)
Non-colinear ordering:: DBP20_RS35475 + DBP20_RS36345 + DBP20_RS35055 + DBP20_RS35465 + DBP20_RS36470 + DBP20_RS35830 + DBP20_RS36550 + DBP20_RS36555 + DBP20_RS34860 + DBP20_RS34870 + DBP20_RS36545 + DBP20_RS36340

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DBP20_RS34770: Acetyl-CoA

CAL_domain (63..504): Acetyl-CoA

minowa: Acetyl-CoA

Prediction, score:

Acetyl-CoA: 42.0
fatty_acid: 19.4
shikimic_acid: 10.1
AHBA: -0.1
NH2: -0.6

DBP20_RS35465: mal - mmal - mmal

PKS_AT (564..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 196.4
inactive: 84.0
Methoxymalonyl-CoA: 66.3
Methylmalonyl-CoA: 51.6
Propionyl-CoA: 17.2
Isobutyryl-CoA: 16.6
Ethylmalonyl-CoA: 15.1
Benzoyl-CoA: 14.4
Acetyl-CoA: 14.3
fatty_acid: 13.5
2-Methylbutyryl-CoA: 9.7
CHC-CoA: 6.8
trans-1,2-CPDA: 6.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (2602..2899): mmal

ATSignature: Methoxymalonyl-CoA, Methylmalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 75.0%; Methylmalonyl-CoA: 75.0%; Ethylmalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 173.9
Ethylmalonyl-CoA: 169.6
Methoxymalonyl-CoA: 151.2
2-Methylbutyryl-CoA: 118.3
trans-1,2-CPDA: 110.0
Propionyl-CoA: 94.8
Malonyl-CoA: 89.9
Isobutyryl-CoA: 82.9
CHC-CoA: 82.0
Benzoyl-CoA: 67.3
fatty_acid: 44.5
3-Methylbutyryl-CoA: 42.0
Acetyl-CoA: 39.9
inactive: 12.8

PKS_AT (4136..4437): mmal

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 153.6
Ethylmalonyl-CoA: 152.1
Methoxymalonyl-CoA: 129.5
2-Methylbutyryl-CoA: 114.4
Propionyl-CoA: 90.9
Malonyl-CoA: 87.0
trans-1,2-CPDA: 82.5
Isobutyryl-CoA: 79.6
Benzoyl-CoA: 58.6
CHC-CoA: 57.1
inactive: 51.0
3-Methylbutyryl-CoA: 25.0
Acetyl-CoA: 22.9
fatty_acid: 22.6

DBP20_RS36470: mal

PKS_AT (575..856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.8
inactive: 85.3
Methoxymalonyl-CoA: 65.3
Methylmalonyl-CoA: 55.7
Propionyl-CoA: 19.8
Ethylmalonyl-CoA: 18.0
fatty_acid: 16.2
Acetyl-CoA: 15.1
Benzoyl-CoA: 15.0
Isobutyryl-CoA: 14.2
2-Methylbutyryl-CoA: 11.7
CHC-CoA: 10.6
trans-1,2-CPDA: 7.5
3-Methylbutyryl-CoA: 0.0

DBP20_RS34860: mal - mal

PKS_AT (575..856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.8
inactive: 85.3
Methoxymalonyl-CoA: 65.3
Methylmalonyl-CoA: 55.7
Propionyl-CoA: 19.8
Ethylmalonyl-CoA: 18.0
fatty_acid: 16.2
Acetyl-CoA: 15.1
Benzoyl-CoA: 15.0
Isobutyryl-CoA: 14.2
2-Methylbutyryl-CoA: 11.7
CHC-CoA: 10.6
trans-1,2-CPDA: 7.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2004..2280): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.6
inactive: 85.3
Methoxymalonyl-CoA: 65.9
Methylmalonyl-CoA: 57.4
Propionyl-CoA: 23.9
Acetyl-CoA: 18.2
Ethylmalonyl-CoA: 17.9
fatty_acid: 16.6
Benzoyl-CoA: 15.5
Isobutyryl-CoA: 11.3
2-Methylbutyryl-CoA: 11.3
CHC-CoA: 10.6
trans-1,2-CPDA: 8.5
3-Methylbutyryl-CoA: 0.0

DBP20_RS34870: mal

PKS_AT (571..837): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.1
inactive: 104.0
Methoxymalonyl-CoA: 74.6
Methylmalonyl-CoA: 68.6
Isobutyryl-CoA: 28.7
Propionyl-CoA: 27.1
Acetyl-CoA: 24.9
Ethylmalonyl-CoA: 24.2
Benzoyl-CoA: 16.4
fatty_acid: 15.2
CHC-CoA: 14.1
trans-1,2-CPDA: 13.7
2-Methylbutyryl-CoA: 11.8
3-Methylbutyryl-CoA: -2.8

DBP20_RS36545: mmal

PKS_AT (1..200): mmal

ATSignature: (unknown)

No matches above 50%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 100.1
Ethylmalonyl-CoA: 82.0
Methoxymalonyl-CoA: 76.3
trans-1,2-CPDA: 45.1
2-Methylbutyryl-CoA: 44.0
Propionyl-CoA: 38.1
Isobutyryl-CoA: 20.5
CHC-CoA: 19.7
Benzoyl-CoA: 19.2
3-Methylbutyryl-CoA: 18.9
Malonyl-CoA: 17.2
Acetyl-CoA: 14.6
inactive: 0.0
fatty_acid: 0.0

DBP20_RS36340: pk - mal - mmal - mal

PKS_AT (583..878): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 218.5
Methylmalonyl-CoA: 217.3
Methoxymalonyl-CoA: 180.9
2-Methylbutyryl-CoA: 146.4
trans-1,2-CPDA: 135.6
Propionyl-CoA: 110.2
Malonyl-CoA: 104.0
CHC-CoA: 102.0
Isobutyryl-CoA: 74.5
Benzoyl-CoA: 64.5
Acetyl-CoA: 43.2
fatty_acid: 36.1
inactive: 31.3
3-Methylbutyryl-CoA: 28.1

PKS_AT (2099..2374): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.9
inactive: 83.5
Methoxymalonyl-CoA: 66.6
Methylmalonyl-CoA: 55.9
Propionyl-CoA: 22.7
Acetyl-CoA: 18.2
Ethylmalonyl-CoA: 17.8
Benzoyl-CoA: 15.7
fatty_acid: 15.3
Isobutyryl-CoA: 13.3
CHC-CoA: 11.1
2-Methylbutyryl-CoA: 11.0
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (3587..3882): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.2
Ethylmalonyl-CoA: 200.2
Methoxymalonyl-CoA: 178.1
2-Methylbutyryl-CoA: 134.7
trans-1,2-CPDA: 133.0
Propionyl-CoA: 115.8
CHC-CoA: 109.3
Malonyl-CoA: 100.3
Isobutyryl-CoA: 75.4
Benzoyl-CoA: 56.5
Acetyl-CoA: 39.4
3-Methylbutyryl-CoA: 34.2
fatty_acid: 32.7
inactive: 28.4

PKS_AT (5115..5400): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.7
inactive: 80.0
Methoxymalonyl-CoA: 75.1
Methylmalonyl-CoA: 63.7
Isobutyryl-CoA: 33.2
Propionyl-CoA: 23.9
Ethylmalonyl-CoA: 23.5
Benzoyl-CoA: 22.5
Acetyl-CoA: 19.1
fatty_acid: 18.8
3-Methylbutyryl-CoA: 11.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

DBP20_RS35475: mmal - mal - mal - mal

PKS_AT (520..817): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 203.8
Ethylmalonyl-CoA: 195.0
Methoxymalonyl-CoA: 164.4
2-Methylbutyryl-CoA: 138.0
trans-1,2-CPDA: 113.4
Malonyl-CoA: 105.8
Propionyl-CoA: 95.9
CHC-CoA: 84.9
Benzoyl-CoA: 75.9
Isobutyryl-CoA: 74.1
Acetyl-CoA: 47.3
inactive: 40.4
fatty_acid: 35.8
3-Methylbutyryl-CoA: 31.0

PKS_AT (1533..1810): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.2
inactive: 85.2
Methoxymalonyl-CoA: 67.6
Methylmalonyl-CoA: 57.1
Propionyl-CoA: 27.7
Ethylmalonyl-CoA: 22.5
Benzoyl-CoA: 15.5
Acetyl-CoA: 15.0
fatty_acid: 14.8
Isobutyryl-CoA: 12.5
CHC-CoA: 10.2
trans-1,2-CPDA: 9.7
2-Methylbutyryl-CoA: 6.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (3221..3498): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.5
inactive: 85.2
Methoxymalonyl-CoA: 62.0
Methylmalonyl-CoA: 51.8
Propionyl-CoA: 19.1
Ethylmalonyl-CoA: 18.1
Benzoyl-CoA: 15.0
fatty_acid: 14.7
Acetyl-CoA: 14.1
Isobutyryl-CoA: 13.4
2-Methylbutyryl-CoA: 9.7
CHC-CoA: 8.8
trans-1,2-CPDA: 7.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (4733..5006): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 196.7
inactive: 85.9
Methoxymalonyl-CoA: 62.3
Methylmalonyl-CoA: 53.7
Ethylmalonyl-CoA: 20.5
Propionyl-CoA: 18.3
fatty_acid: 16.4
Benzoyl-CoA: 15.1
Acetyl-CoA: 15.0
Isobutyryl-CoA: 13.4
2-Methylbutyryl-CoA: 11.3
CHC-CoA: 10.4
trans-1,2-CPDA: 8.9
3-Methylbutyryl-CoA: 0.0

DBP20_RS36345: mal - mmal

PKS_AT (531..809): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.5
inactive: 92.0
Methoxymalonyl-CoA: 72.3
Methylmalonyl-CoA: 64.1
Isobutyryl-CoA: 28.0
Propionyl-CoA: 25.2
Ethylmalonyl-CoA: 24.8
Acetyl-CoA: 22.1
CHC-CoA: 20.6
Benzoyl-CoA: 19.2
2-Methylbutyryl-CoA: 16.4
fatty_acid: 12.0
trans-1,2-CPDA: 6.9
3-Methylbutyryl-CoA: 2.9

PKS_AT (2535..2831): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.8
Ethylmalonyl-CoA: 190.4
Methoxymalonyl-CoA: 147.5
trans-1,2-CPDA: 123.7
2-Methylbutyryl-CoA: 120.0
CHC-CoA: 103.2
Propionyl-CoA: 96.1
Malonyl-CoA: 81.6
Isobutyryl-CoA: 59.2
Benzoyl-CoA: 49.7
Acetyl-CoA: 45.7
3-Methylbutyryl-CoA: 29.6
inactive: 26.3
fatty_acid: 26.3

DBP20_RS35830: mal - mmal

PKS_AT (559..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.3
inactive: 99.9
Methoxymalonyl-CoA: 61.4
Methylmalonyl-CoA: 54.9
Propionyl-CoA: 32.5
fatty_acid: 27.1
Ethylmalonyl-CoA: 19.1
Isobutyryl-CoA: 18.4
Benzoyl-CoA: 17.7
Acetyl-CoA: 16.0
2-Methylbutyryl-CoA: 13.7
CHC-CoA: 10.7
trans-1,2-CPDA: 8.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2064..2360): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.8
Ethylmalonyl-CoA: 190.4
Methoxymalonyl-CoA: 147.5
trans-1,2-CPDA: 123.7
2-Methylbutyryl-CoA: 120.0
CHC-CoA: 103.2
Propionyl-CoA: 96.1
Malonyl-CoA: 81.6
Isobutyryl-CoA: 59.2
Benzoyl-CoA: 49.7
Acetyl-CoA: 45.7
3-Methylbutyryl-CoA: 29.6
inactive: 26.3
fatty_acid: 26.3

DBP20_RS36550: mal

PKS_AT (1680..1962): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.9
inactive: 103.8
Methoxymalonyl-CoA: 72.1
Methylmalonyl-CoA: 64.9
Propionyl-CoA: 31.4
Ethylmalonyl-CoA: 31.2
2-Methylbutyryl-CoA: 25.5
fatty_acid: 22.9
Isobutyryl-CoA: 18.6
Acetyl-CoA: 16.0
CHC-CoA: 15.6
Benzoyl-CoA: 13.3
trans-1,2-CPDA: 11.9
3-Methylbutyryl-CoA: 0.0

DBP20_RS36555: mal - mal

PKS_AT (513..793): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.0
inactive: 98.3
Methoxymalonyl-CoA: 69.4
Methylmalonyl-CoA: 65.6
Propionyl-CoA: 36.0
Isobutyryl-CoA: 34.7
Ethylmalonyl-CoA: 31.1
fatty_acid: 29.6
Benzoyl-CoA: 28.7
CHC-CoA: 21.9
2-Methylbutyryl-CoA: 21.5
Acetyl-CoA: 20.5
trans-1,2-CPDA: 13.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (2027..2309): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.7
inactive: 105.4
Methoxymalonyl-CoA: 68.2
Methylmalonyl-CoA: 59.1
Propionyl-CoA: 27.1
Ethylmalonyl-CoA: 26.4
2-Methylbutyryl-CoA: 21.8
fatty_acid: 21.1
CHC-CoA: 17.2
Acetyl-CoA: 15.8
Benzoyl-CoA: 13.3
Isobutyryl-CoA: 12.5
trans-1,2-CPDA: 11.1
3-Methylbutyryl-CoA: 0.0