LOCUS       NZ_KZ819178            22883 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. CS131 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ819178
VERSION     NZ_KZ819178.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS131
  ORGANISM  Streptomyces sp. CS131
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7968990)
  AUTHORS   Malmierca,M., Ceniceros,A., Mendez,C., Salas,J.A. and Olano,C.
  TITLE     Genome analysis of twelve Streptomyces spp. associated with Peruvian
            leafcutter ants
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7968990)
  AUTHORS   Malmierca,M., Ceniceros,A., Mendez,C., Salas,J.A. and Olano,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-APR-2018) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.88x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003116755.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 09:38:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,994
            CDSs (total)                      :: 6,912
            Genes (coding)                    :: 6,769
            CDSs (with protein)               :: 6,769
            Genes (RNA)                       :: 82
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 143
            CDSs (without protein)            :: 143
            Pseudo Genes (ambiguous residues) :: 0 of 143
            Pseudo Genes (frameshifted)       :: 41 of 143
            Pseudo Genes (incomplete)         :: 122 of 143
            Pseudo Genes (internal stop)      :: 12 of 143
            Pseudo Genes (multiple problems)  :: 31 of 143
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:40:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4508816
            Orig. end                         :: 4531699
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ819178.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Professor JA Salas
            laboratory.
FEATURES             Location/Qualifiers
     region          1..22883
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="19"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22883
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22883
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12883](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12883)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            complement(107..346)
                     /locus_tag="DBP20_RS20410"
                     /old_locus_tag="DBP20_20425"
     CDS             complement(107..346)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610436.1"
                     /locus_tag="DBP20_RS20410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20425"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_109179629.1"
                     /transl_table=11
                     /translation="MSTDLHWFKSSYSGSEGGNCVEVALTWSKSTYSGSEGGDCVEVAT
                     CPHTVHIRDSKDLTVPALAVSPASWTSFVEFAAS"
     gene            complement(343..1170)
                     /locus_tag="DBP20_RS20415"
                     /old_locus_tag="DBP20_20430"
     CDS             complement(343..1170)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510895.1"
                     /locus_tag="DBP20_RS20415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20430"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_109179630.1"
                     /transl_table=11
                     /translation="MHSSDQPESTAEMFGLLLRHFRVLAGLSQDQLGKRIGYSKSQVAM
                     VERGARPPTDVFVQRADEVLGAQGALLVAAPKPLKQTERRNPLPGWFTPFADEEEKAWA
                     RHEYENHVMPGLLQTEAYARAVFTSRYPTYDDDEIEAKVAARLERQKLLSRRPLPDISF
                     VLEMIALTRPIGGRRVMKAQLRHLAEVARLRHVRIQLMDPDREDHAALDGPFVLLETDK
                     RQQLAYIEGQGGSFFVTEQPELGNLFGKYGVTRAQAYTPERTLEKIEKMAEEL"
     misc_feature    complement(1210..1225)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            1253..1687
                     /locus_tag="DBP20_RS20420"
                     /old_locus_tag="DBP20_20435"
     CDS             1253..1687
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958696.1"
                     /locus_tag="DBP20_RS20420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20435"
                     /product="hypothetical protein"
                     /protein_id="WP_109181553.1"
                     /transl_table=11
                     /translation="MELKNSPDPVPFHPSWIPASGHALRHVGIHFDAVRAIGMLGEEIA
                     YEVMQFTDFQAGPIVRSGIGERSMYFLLAPGTAAEHRWPPGVEAMSRSARGDAFVGVPA
                     LGGGTWPLDWRSRPTVQDPFVDGALLHEMAWLRARCAVRD"
     gene            complement(<1788..2042)
                     /locus_tag="DBP20_RS20425"
                     /old_locus_tag="DBP20_20440"
                     /pseudo=""
     CDS             complement(<1788..2042)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014505.4"
                     /locus_tag="DBP20_RS20425"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20440"
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRRGEVWWVEFDERRPVVLLAGDDASGIRVMQVVAPAGVDISGLG
                     IEVAVGASEGLPCEGVLRFALPRPGLTPCTWLTTVSRDDL"
     gene            2227..3336
                     /locus_tag="DBP20_RS20430"
                     /old_locus_tag="DBP20_20445"
     CDS             2227..3336
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126601.1"
                     /locus_tag="DBP20_RS20430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20445"
                     /product="hypothetical protein"
                     /protein_id="WP_109179631.1"
                     /transl_table=11
                     /translation="MLSHVIPPPWGYTKASNSLVRHARIGSDAKILVLYIQGLPEEDRD
                     KPLSEHARALRMTGRAYQKAKADLVTYGYVHEKREHLSNGRWRTVQVFGNQPLTDNQAA
                     RLRAGVPADGYENTDGSAVPDAWSAPTTHFPTVGQPTPRWVGGLLPADEEQGEDSSHPP
                     TEAAEPEKTAEEPVAAVTGAEVEEAGEEPQAPSQEELVLAERVLLSLKHQARQLTLGVR
                     EARKLAGLAAEWLRRGVSAGDLRLALSSALPAEGVRTAFGFLAHRLVEKLPPRPEEVAE
                     SASPPPSAPLPLVACDGPGEEHVFRPHMSWVTTCGPCNRAQQRADAELMLARAQADPAP
                     PPPSWRERVAAEARADEVASGYGTRATAT"
     gene            complement(3309..4094)
                     /locus_tag="DBP20_RS20435"
                     /old_locus_tag="DBP20_20450"
     CDS             complement(3309..4094)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126602.1"
                     /locus_tag="DBP20_RS20435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20450"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_032764395.1"
                     /transl_table=11
                     /translation="MTAQAPHPPIDTSKPHSARVYDALLGGKDNYPVDQQVAELLPAEA
                     KVGARQQRSFMNRATAWLAGEGVTQFLDIGTGIPTEPNLHQTAQEIRPSARVVYCDNDP
                     IVLRHAEALLVSRPEGVTDYVHADVREPAIILDAARETLDFDRPIALSLLGLLHFLPDA
                     EKPIDIVRTFTDAMAPGSYVVLSHGASDVNEEKGEQAGDEYKKGGIQLALRSREEFSRF
                     FEGLEIVAPGLVKAPEWFNGTPAPTQEFSGIYVAVARVP"
     misc_feature    4112..4127
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.7"
                     /tool="antismash"
     misc_feature    complement(4119..4134)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.18"
                     /tool="antismash"
     gene            complement(4153..5949)
                     /locus_tag="DBP20_RS20440"
                     /old_locus_tag="DBP20_20455"
     CDS             complement(4153..5949)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020551013.1"
                     /locus_tag="DBP20_RS20440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20455"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_109179632.1"
                     /transl_table=11
                     /translation="MSESAPRPVDRHLFAGFLRQHRGAAVAVAGWSLLEAVPALASGLL
                     VAAALDRGFLAGRPAEGFLWIGLLGAAMVFRALMTRTLTPWLGRLVEPLRDELVTAVAA
                     GAVHRAAAGARDTAGAGVARLTVQVETVRALVSALLRSARQLGVSLLMAFVGLAALSAP
                     VAAVTLPPVLLTLLLCVPRLRVLARRQGRQLRAEEALTAAAGETFDGIRDVVACGARDR
                     VADDLSARITDHRDAVRAVARTASANTLLVSLGSHLPLLVLLLAAPRLLDRGALSVGEL
                     LGATSYLISGVAPALRSLVAVLGSWGVQLATVLGRLSRSTAPARRAPARAPGPDIPARR
                     VPARAPGPDAFARTPRSPDLSLVDVGYAYGPGAAPVIDGLSLDLPAGSHLTVVGPSGAG
                     KSTLTTLLAGLAAPDDGRLTLGGVPVTEVDRAWLHREVTLIPQEAYVFTGTVRDNLRYL
                     TPRARDADLLASAEAVGARALVDRLGGLDAPVGLDGPPLSSGERQLVALARAHVSPASV
                     VLLDEACCHLDPAAEERAERAFAARGTTLVVVAHRISSALRAPRVLVLDGERTAIGTHA
                     QLLGESPLYADLVGHWVAAGTP"
     gene            complement(5946..7685)
                     /locus_tag="DBP20_RS20445"
                     /old_locus_tag="DBP20_20460"
     CDS             complement(5946..7685)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004940770.1"
                     /locus_tag="DBP20_RS20445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20460"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_109179633.1"
                     /transl_table=11
                     /translation="MTSPQRLVWDATARTRGWFALASATAVLGSAGTLAFPWAMARALD
                     AVVARRPATGPVLVCAALLALVVTTGALQTLANGGYGSGTVAVLRRSLARRALDAGVPG
                     TADFAAGDLAGRLSAGCAQAGSAGVTLVTASAAVLTSLGGVVALWLLDWRIGLCFSLGV
                     PPLVLIARGFMNRGSGLFLRYQEAQGRISALLLEALGGARTIGASGTAAAETRRVLEPL
                     PELSRTGHRVWALQRDTGWQVGLLIPAVEVLVLCAGGLALLHGDISAGELAAVVAYTAL
                     AMAALDQLDALFALGMSAAGARRVAEVVDQPVPAPGTRSRPAAGPGTVTLSGVTVRSGT
                     RLVLDAVDLVVPAGTALAVVGRSGAGKSTLAALVGRLREPDAGLVAIDGVPLRELTPRA
                     LRAAVGYAFERPALLGTTVAGTIAFARPDASRQEVAAAAGAARADDFIARLPHGYDTPL
                     RDAPLSGGEVQRLGLARALVHDPAVVVLDDALSSLDTATEAQVGSALASAWSGRTRVLI
                     AHRVSTAARADLVAWLEDGRVRALGTHADLWQRGDYRALFATDTAPEGVPGHGTDPHTR
                     ESA"
     gene            complement(7858..7989)
                     /locus_tag="DBP20_RS35670"
     CDS             complement(7858..7989)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038157.1"
                     /locus_tag="DBP20_RS35670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ALQxL family class IV lanthipeptide"
                     /protein_id="WP_189460106.1"
                     /transl_table=11
                     /translation="MIDNTMTVDVDELQTLEGEESVALAGCTRTCTWTCSITSIEQQ"
     CDS_motif       complement(7912..7989)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIDNTMTVDVDELQTLEGEESVALAG"
                     /locus_tag="DBP20_RS35670_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7858..7911)
                     /prepeptide="core"
                     /locus_tag="DBP20_RS35670_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.70"
                     /molecular_weight="1835.1"
                     /monoisotopic_mass="1833.8"
                     /core_sequence="CTRTCTWTCSITSIEQQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIDNTMTVDVDELQTLEGEESVALAG"
                     /leader_location="[7911:7989](-)"
                     /alternative_weights="1853.1"
                     /alternative_weights="1871.1"
                     /alternative_weights="1889.1"
                     /alternative_weights="1907.1"
     gene            complement(7986..10004)
                     /locus_tag="DBP20_RS20450"
                     /old_locus_tag="DBP20_20465"
     CDS             complement(7986..10004)
                     /NRPS_PKS="Domain: Abhydrolase_1 (407-507). E-value: 2e-08.
                     Score: 26.1. Matches aSDomain:
                     nrpspksdomains_DBP20_RS20450_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.4"
                     /locus_tag="DBP20_RS20450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20465"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_109179634.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-05, bitscore: 23.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.2e-19, bitscore:
                     68.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRHPQRISFRFSARSRFAACLVATADGAPAPGWWDLDGTRPPYA
                     GGTPRYREGAPAETTATQVLPTEDGGLLRLRGAAGSGRHLLLLSPAESLSPAEDPAEPP
                     ARGPAEDPAERLPVGARGLRLVPGGPRGTLALAVETAHDGRTRVWRVLPAPLRLSDPLT
                     LPGRVTALLPLDGTGCRYATDLEGPDGHRPVSLDLRDGRWHALPSPANGRVHRLLLSAP
                     ASGLLLTAGDPGDGRLRIAHATLGERPRLDFPDRLNSLDGAVLPLAADPAGERVALRVS
                     RGAQARLFLYDVGADQPRPAELPPGAFHPVAGWSAGGLRVVYATPDRPADLVTVPGTAT
                     HPARYDAAYEPASDTREARSGTQRSSSGTLGTPSDASGTPHAPTEWFATPSGRFEAVRL
                     GDWRTAPTVVVALHGGPEDHWTLGHDPVLARLSEAGAAVVAPNQRGSTGYGRAHAEAIH
                     GAWGVPDLADIRVLVRTLTEQRPPGAEPPVLLGTSYGGFLALLAVCADPYTWARCAVIA
                     PFLSARGLRERSSPAVRALIDRHGLGEPPDDDLGPRDVERLAHRIRVPVLALHGCDDPV
                     VPVDETHRLRRALTAAGGPERAPHDCLDIAGAGHHPLQERGGAELTDRLVSFLTAGFPD
                     RRRSPAPPGLTVADAAVRHRPSSAVFGHITHDERTPS"
     aSDomain        complement(8484..8783)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DBP20_RS20450_Abhydrolase_1.1"
                     /evalue="2.00E-08"
                     /label="DBP20_RS20450_Abhydrolase_1.1"
                     /locus_tag="DBP20_RS20450"
                     /protein_end="507"
                     /protein_start="407"
                     /score="26.1"
                     /tool="antismash"
                     /translation="VVVALHGGPEDHWTLGHDPVLARLSEAGAAVVAPNQRGSTGYGRA
                     HAEAIHGAWGVPDLADIRVLVRTLTEQRPPGAEPPVLLGTSYGGFLALLAVCADP"
     CDS_motif       complement(8502..8543)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DBP20_RS20450_0001"
                     /evalue="1.30E-01"
                     /label="NRPS-te1"
                     /locus_tag="DBP20_RS20450"
                     /protein_end="501"
                     /protein_start="487"
                     /score="5.0"
                     /tool="antismash"
                     /translation="VLLGTSYGGFLALL"
     gene            complement(10001..12883)
                     /gene="lanL"
                     /locus_tag="DBP20_RS20455"
                     /old_locus_tag="DBP20_20470"
     CDS             complement(10001..12883)
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="DBP20_RS20455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20470"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_162600197.1"
                     /sec_met_domain="Pkinase (E-value: 7.4e-13, bitscore: 47.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.1e-42, bitscore:
                     143.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDCDEHDSGSFFALDTGLLPGIVDGVLHRRGATGWAVDQGEFW
                     CSVRPRGHRSGEQGWKLHLSATPLSAALVLAVAADVLIGERASFKFAGSLDRVALLTGG
                     RADRGGGGKFITVYPDDPELFRRLARRLHAATLGLRGPRILSDQPYAPGSLVHYRYGVF
                     GGVRTTTNDGDTDVRLRNPAGELEKDRRQAWVTTPAWAPPPFPEPTSPPGATSNPSRAQ
                     TGPLEQTGPRQPTRTPGRKSVRLNGRYVVAKAIRHAFKGGVYLATDETTGRQVVVKEAR
                     AHVGVRMDGTDLQDTLRHEAEMLEALAPLGCTPAAIELFAQGGNLFLAQEFVPGRTLRD
                     RLVERPVRDLAEFLHLGRQIVDIVAGVHGTGRVLRDLSPNNLMVTPEGRVRLIDVEYLA
                     PEGVPVRRGYTPGYVGPEVSSLRDYDFTAPTYAGDLYGLGAVLLHLATGVDMLLVPDGR
                     PVGDRTEALIALAIADRPWAAPLLPLLLALCAPLPEGRWELSRVRRVLAELPGTGHRPT
                     GGTGHRPTGGTGVTGPGAGGGSGVAALADEERERLIADGLAYLLRTRPGSGGHLWDVSS
                     FGATTDPLNVQYGSAGVLAVLTRAAAAGAGPDVRHGVAELTEWTRRRLADLPTGRTPDG
                     TLLPGLHFGRSGTAWALLDAALLLGDEDVAAEASALARAVPVDWPNRDICHGAAGAGMT
                     QLHFWRTTGDPAFRDRAVACAGAIVEAAEDHPSGVIWPVPAAFDSNLAGARHYGFAHGI
                     AGIGAFLLAAGVAADHAGLLQGARAVGDTLVRLARVEDGRAVWPAGDRDADGPVGQTHW
                     CSGSSGIGTFLVRLWARTGDERYREAAVGAAAGVRDAMWLSSPAACHGLAGNAEFLLDM
                     SAALGDPRYREQAGELAACIHTRAVRRDGLLVVPDESLEAVTGGYQTGAAGTVGMLLRL
                     RDGGPRLWMPDTPDLFAPAGRHPRTAVGAR"
     misc_feature    complement(13113..13127)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     misc_feature    complement(13230..13244)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.38"
                     /tool="antismash"
     gene            13238..14404
                     /locus_tag="DBP20_RS35405"
     CDS             13238..14404
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DBP20_RS35405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_141720295.1"
                     /transl_table=11
                     /translation="MVIATALYRGSHLVAGGSVVTQHQRDRPFPWLALVAAIAATALIW
                     FMAARHRRLVSWAVGLDVLVIGCLLPFGAYVWGGARTQESIAWVMLLGGSASAMAAVAF
                     GARLLAVAVVLLVATHLAGYLLVEADAAVTGAHLNALVFSAVVSWVLTWYLCRQGEQVD
                     AANRRALDAEAQRARFAERVAHHNALHDTVLATLTAIARGGVDANTSMMRERCAREAAY
                     LRRLVEEADDREHASEVRAALEESVRAAEALGLRVTARYHALPAVPGEIALTMARAATE
                     ALNNVRCHAGTGHAFLTAAGDSGRLVVTVVDRGRGFAVEGAGRQGASGPAGAEASGGSV
                     VRAASVPPATGGIGLDRCVYARMRGVGGRALVDSAPGEGVRVELRWPG"
     gene            14392..15024
                     /locus_tag="DBP20_RS20460"
                     /old_locus_tag="DBP20_20475"
     CDS             14392..15024
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061151.1"
                     /locus_tag="DBP20_RS20460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20475"
                     /product="response regulator transcription factor"
                     /protein_id="WP_093440155.1"
                     /transl_table=11
                     /translation="MAGVISVAVVDDDRMLRDGIRSWFADVEEVDLVACAATVDELLAG
                     HGEPPDVVLLDLMLRDDRTSADNIRRLRTAGSRVLMISVVADRDRIVAAVTDGADGFLT
                     KDQELSVLVEAVREIAAGRTAHSPELAFALAYDRGPARPRLSPQEREVLVGYASGLTLK
                     ATARRTGITVNTAKYYLDRVKAKYQEAGRPTYTKIDLATRVREDGWR"
     gene            15058..16200
                     /locus_tag="DBP20_RS20465"
                     /old_locus_tag="DBP20_20480"
     CDS             15058..16200
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126603.1"
                     /locus_tag="DBP20_RS20465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20480"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_239475351.1"
                     /sec_met_domain="Abi (E-value: 7.9e-15, bitscore: 53.7,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHPSDQPSSSPSPSPWSPPSGDAPRTDGPPPSPWAPPSSAAEPP
                     HPPAAAWQTGQAGQAWPGGQGWDRPPEWSRPPTGPERAPSGSRYDEQGRNGRGGRFGWI
                     GELSAVVGLVVAGVLVVSIGGFVLAELLDAGPTDPDSDLFFEDPVADLVVQLLGIAIAI
                     PVVLWGARVIGRRPAGTVSSVVGRLRWGWLARCAAVGFPLMVVQIGVLIAWTWNDEPVG
                     ESGTGFPGWSVFLLSLAVILALVPFQAAAEEYVFRGWLVQVIGRVARTPWPAVAVASLL
                     FALAHGFGELSGFLLLLYSALWWGWLVIRTGGLEAVIVMHVANNLLAFGLAAGFGELAA
                     TETAADAPWQAMVAELVFAPLYCLTVARIADRRGIERVSP"
     gene            complement(16242..17435)
                     /locus_tag="DBP20_RS20470"
                     /old_locus_tag="DBP20_20485"
     CDS             complement(16242..17435)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071676.1"
                     /locus_tag="DBP20_RS20470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20485"
                     /product="ABC transporter permease"
                     /protein_id="WP_109179637.1"
                     /transl_table=11
                     /translation="MTHALKPARLSPRDVLRVGAVGLRARRARVVLSALGIAIGIATMV
                     AVVGLSESSRADLMSRLDRLGTNLLTAEAGETPLGGTVELPKNAVAMVERIGPVLHATA
                     TAEVDARVRRSDVVPEERTAGVTTQAARTDLLATLGGEVARGTWLTPAGERLPTTVLGA
                     VAADRLGVTRPGETIMMNDVRVAVVGILEPVELVPTLDRVALVGFPAAERYFGFDGRPT
                     TVFERSTDASVEDVREVLARTVSPGNEAAVRVSRPSDALAARAAADKGLTALMLGLGAV
                     ALLVGGVGVANTMVISVLERRQEIGLRRSLGATRAAIRLQFLTESLLLSALGGVTGALL
                     GAAATYGFARAQGWTAVVPPWSLAGGLAATLLIGVVAGLYPAIRAARLHPTVALNAT"
     gene            complement(17432..18250)
                     /locus_tag="DBP20_RS20475"
                     /old_locus_tag="DBP20_20490"
     CDS             complement(17432..18250)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007450074.1"
                     /locus_tag="DBP20_RS20475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20490"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_109179638.1"
                     /transl_table=11
                     /translation="MSTPPPPRPAPAVTAPPQARSAVTAPPPTPVVELRNATKSYPGGV
                     HALRAVNLTVHEGELLAVVGPSGSGKSTMLNVMGTLDRPTTGTVRVAGYDVSALPDARL
                     SALRARHIGFVFQHFHLAAGRDAVDNVADGLLYAGVGSRERRERARDALARVRLDHRAS
                     HTPNELSGGEKQRVAIARALVGEPRLLLADEPTGALDTASGAIVMELLHELNASGTTVC
                     VITHDQQIAAALPRRVRFRDGEIVSDDRSTTAGFGVTVDGARTDDTEAGA"
     gene            complement(18247..19323)
                     /locus_tag="DBP20_RS20480"
                     /old_locus_tag="DBP20_20495"
     CDS             complement(18247..19323)
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007450070.1"
                     /locus_tag="DBP20_RS20480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20495"
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_109179639.1"
                     /transl_table=11
                     /translation="MKRSTTALLALGTVTAAVTGGVLFLGAGDGTGSPGRGGDGLPPAT
                     ATVVRTDLVLARTVDGRIDFAQRRAVKAAVEGTVTVAAAEGRTVRRGEALYELNDKPVT
                     LLYGPVPAFREMKKGHRGSDVLQLERNLRDLGYGAGLYVDTEYGEDTESAVKRWQKHLN
                     RETTGRIGRGDVVFQPGEVKVVSADAALADQVGPDAPVLTIASTRPVVRAVLEQTDGAL
                     TARGTKVEVTLPSGKTVPGKVAGTVRPEGEDGTEGGGQEGITVEVVLDGGSRAASGEDA
                     EAAASVTFVSEAREGVLAVPVEAVVALRGENGGYGLQVVKGGTSEMIRVETGMTADGRI
                     EVSGAGLRAGMKVGVAKQ"
     gene            complement(19320..19970)
                     /locus_tag="DBP20_RS20485"
                     /old_locus_tag="DBP20_20500"
     CDS             complement(19320..19970)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071678.1"
                     /locus_tag="DBP20_RS20485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20500"
                     /product="hypothetical protein"
                     /protein_id="WP_109179640.1"
                     /transl_table=11
                     /translation="MSFPTTTAGLRLAALVAVPVLALSVACGGSDDATGTRSHDAIADV
                     PSPKTEPSTDGNAEEQTSPSAKPAGKSAFYDAQVAFVQCMRSKGGYKDYPDPKLSGHLD
                     WTKINEIGSRPGRNEGIKAGKNGVCVAELQAAMAAEPERDQQKAYESMLAHAQCMRDNG
                     ISRFTNPVMSGGNAIPGGDPNPGSPVYDRESPAYKEAREACKEKLLDGLDGMQ"
     gene            20106..20807
                     /locus_tag="DBP20_RS20490"
                     /old_locus_tag="DBP20_20505"
     CDS             20106..20807
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958679.1"
                     /locus_tag="DBP20_RS20490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20505"
                     /product="response regulator transcription factor"
                     /protein_id="WP_109179641.1"
                     /transl_table=11
                     /translation="MPHVLLIEDDTSVRDGMELVLRRHGYGVETAATGEEALALLAGER
                     GARVELAVLDLMLPGMDGFEVCRRIRARTAALPVIMLTARGDDRDIVAGLEAGADDYVV
                     KPVTAPVLEARIRAALRRAEPSLRQGPDADVTDLAGLVIDRAGLTVTRNGIPVPLPPTE
                     LRLLLELSASPGRVFTREQLLASVWDHTFLGDSRLVDAAVGRLRAKIEEVPGKPRYVQT
                     VRGFGYRFGPL"
     gene            20981..22462
                     /locus_tag="DBP20_RS20495"
                     /old_locus_tag="DBP20_20510"
     CDS             20981..22462
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071679.1"
                     /locus_tag="DBP20_RS20495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_20510"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_109181554.1"
                     /transl_table=11
                     /translation="MRVRLVVTFVLVALLSAVTATALAYRDARTAILQRTQNTAVNDLR
                     ERVATVAAGFDLPPDQRSLSRFAAQVSEGLGARIVVARHQDLTAVSDAYAATEGRITAE
                     LRAAVRAGDGARFQRVQWRGEPYLVVGMPVTYADGDRRTSGLEVFAITDLRAERDDTAA
                     LLDSVREGTVPVVVAAALLALLAAGTVLRPVRKLGRATRELAAGDLGSRVVVRGHDELA
                     HLARTFNETADALQASDAELRAQEAKARRFVADVSHELRTPLAAMTMVATVLEEDADQL
                     PPDAARAARTVGAETARLSRLVEDLMEISRFDAGAVRLNAFEADLAETVRASLALRGWT
                     DRVTAELPEGVRAVVDRRRVDVIVANLVGNALRHGAPPVTVTLTAPGGDEDRVARLEVA
                     DHGPGLPPEARARVFDRFYKADEARTRNTSTAGSGAEADRESGGRGSGLGMAIALENAR
                     LHGGTIEVGERAGGGAVFTLVLPLRRTDADGEGER"
ORIGIN
        1 ggcggtgtcc gaccacggtg tgaatccggt ggggtggaga tcggatgagt actcgcggtt
       61 cgtcgccatt cgttcaccct gtcacggtca catcggagtg actcgtctag gacgcggcga
      121 actccacgaa ggacgtccag gaggcggggg agacggcgag cgcggggaca gtgaggtcct
      181 tggagtcgcg gatgtggacg gtgtgggggc aggtggccac ctcgacgcag tcgccgccct
      241 cactgccgct gtaggtggac ttggaccagg tgagggccac ctctacacag ttgccgccct
      301 cgctgccgct gtagctggac ttgaaccagt ggaggtcggt actcatagtt cctctgccat
      361 cttctcgatc ttctccagcg tcctctccgg agtgtatgcc tgggcccgtg tgacgccata
      421 cttgccgaac aggttcccca gttccggctg ttcggtgacg aagaagctgc cgccctggcc
      481 ctcgatatag gccagctgct ggcgcttgtc ggtctccagt aggacgaacg ggccgtccag
      541 cgccgcgtgg tcctcgcggt ccgggtccat cagctggata cgtacgtgcc gcagccgtgc
      601 cacctcggcg aggtgacgga gctgggcttt catcacgcga cggccgccga tcggccgggt
      661 cagcgcgatc atctccagga cgaagctgat gtcggggagc ggcctgcggg acagcagctt
      721 ctgccgttcg agtcgcgcgg cgaccttcgc ctcgatctcg tcgtcgtcat aggtcgggta
      781 ccggctcgtg aagacggccc gtgcgtacgc ctcggtctgg agcagaccgg gcatgacgtg
      841 gttctcgtac tcgtgcctcg cccaggcctt ctcctcctcg tccgcgaaag gcgtgaacca
      901 gcccggcagg gggttgcgcc gctccgtctg cttcagcggt ttcggcgcgg cgaccaacag
      961 tgcaccctgt gcacccagca cctcgtccgc ccgctgcacg aagacgtcgg tcggcggtcg
     1021 ggcgccccgt tccaccatgg cgacctggga cttggagtag ccgatccgct tacccagctg
     1081 atcctgtgac agcccggcca gcacgcggaa gtgccgcagg agcagaccga acatctcggc
     1141 ggtgctttcc ggctgatcac tggagtgcac gggctcacct cacatgtaca ccactgttca
     1201 caacgtcctt gtgaccctgg tcaccgtacg tgtcggtcgc gaagctgagc gcatggaact
     1261 gaagaattca ccggatccgg tccccttcca cccctcttgg atccccgctt ccggccacgc
     1321 cctccgccat gtcggcattc acttcgacgc tgtccgggcc atcggcatgc tcggcgagga
     1381 aatcgcttac gaggtaatgc agttcaccga cttccaggcc gggcccatcg tccgctccgg
     1441 catcggcgag cgcagcatgt acttcctgct cgcacccggg accgccgccg agcaccggtg
     1501 gcctcccggg gtggaggcga tgagccggag tgctcggggc gacgcgttcg tcggggtgcc
     1561 cgcgctgggc ggcgggacct ggccgctgga ctggcggtcg cggcccacgg tccaggatcc
     1621 gttcgtggac ggtgcgttgc tgcacgagat ggcctggctg cgggcgaggt gcgccgtgcg
     1681 ggactgaacg aggctgctgc cgccccggcc tgcgcgagtc cgccgcgtcg gagggcctcc
     1741 tcgatctcgg tgagcttcgc tgaggacagg gcgcccgccc gctcgatcag gtcgtcccgc
     1801 gacacggtgg tcagccacgt gcaaggggtg aggcccggac gcggcaacgc gaaccggagc
     1861 acgccttcgc agggcagccc ttcggaggcg cctacggcca cttcgatgcc caggccgctg
     1921 atgtcgacgc ccgccggagc gacgacctgc atcacccgga tcccggacgc gtcgtctccc
     1981 gccagcagga cgaccggccg ccgctcgtcg aactcgaccc accagacttc gccacgtcgc
     2041 acaggtcctc ctgacgcggg acggcgggcg gacggagcgt gatcgaggcg tcacgttctg
     2101 cggtaacgtg atctccaaca tcacgctccg cgtgccgcgt tgtgcggtgc atggagcggc
     2161 ccccggaggt gtatcgagca ccaacccgag ggccttcacc actagtggat caggagtcca
     2221 cccgcgatgc tctcgcatgt tatcccgccc ccttggggct acacgaaggc ctccaacagt
     2281 ctggtgcgtc acgcgcgcat cggcagcgac gcgaagattc tcgtgctcta catccagggg
     2341 ctgcccgaag aagaccggga caagcctctg agtgagcacg cccgcgctct ccggatgacc
     2401 ggtcgcgcct accagaaggc caaggccgat ctcgtgacgt acgggtacgt gcacgagaag
     2461 cgggagcacc tctccaacgg gcggtggcgg accgtccagg tcttcggcaa ccagccgctg
     2521 acggacaatc aggccgcccg gcttcgcgcc ggtgttcccg ccgacgggta cgagaacacc
     2581 gacggttctg ccgtgccgga tgcctggtca gctccgacta cgcactttcc gacggtcggt
     2641 cagccgactc ctcggtgggt cggtggtcta ctacccgcgg acgaagaaca gggcgaagac
     2701 tcttcccacc cacccaccga agcggccgag ccggagaaaa cagccgaaga gcccgtagcg
     2761 gccgtaacgg gcgcggaagt ggaagaggcg ggtgaggaac cgcaagcgcc ctcgcaggag
     2821 gaactcgtcc tcgccgagcg cgtgttgctg tcgctcaagc accaggcccg tcagctcacc
     2881 ctcggcgtgc gcgaggcccg caagctcgcc gggctcgccg ccgagtggct gcggcggggg
     2941 gtgagcgccg gggacctgcg gctggcgctc agcagcgcct tgccggcgga aggagtgcgc
     3001 acggccttcg ggttcctggc gcaccggctg gtggagaagc tgcccccgcg tccggaggag
     3061 gtggcggaga gcgcgtctcc gccaccgtca gcgcccctgc ccctcgtcgc ctgcgacgga
     3121 cccggtgagg agcacgtgtt ccggccgcac atgtcgtggg tcactacctg cgggccctgt
     3181 aaccgtgcgc agcaacgcgc cgatgcggag ctgatgttgg cccgagccca ggccgacccc
     3241 gcgcctccgc cgccgtcctg gcgggagcgt gtcgccgccg aggcccgcgc tgatgaggtc
     3301 gcttccggtt acgggacccg ggccacggcc acgtagatgc cgctgaactc ctgcgtgggc
     3361 gcgggcgttc cgttgaacca ctccggggcc ttcaccaggc ccggagcgac gatctccagg
     3421 ccctcgaaga accgggagaa ctcctcgcgg ctccgcaggg ccagctggat gccgcccttc
     3481 ttgtactcgt ccccggcctg ctcccccttc tcctcgttca cgtcggacgc accgtgggac
     3541 aggacgacgt aactgccggg cgccatcgcg tcggtgaacg tacggacgat gtcgatcggc
     3601 ttctcggcgt cggggaggaa gtggaggagg ccgagcagcg acagggcgat cgggcggtcg
     3661 aagtccaggg tctcgcgggc cgcgtcgagg atgatcgcgg gctcgcggac atccgcgtgg
     3721 acgtagtccg tcacgccctc gggccggctg accagcagcg cttccgcgtg ccgcaggacg
     3781 atggggtcgt tgtcgcagta gacgacccgg gcggaggggc ggatctcctg ggccgtctgg
     3841 tgcaggttcg gctcggtggg gatgcccgtc ccgatgtcca ggaactgcgt gacgccctcg
     3901 cccgccagcc aggccgtcgc ccggttcatg aaggaacgct gctgccgggc gcccaccttc
     3961 gcctcggcgg gcaggagctc cgccacctgc tggtccaccg ggtagttgtc cttgccgccg
     4021 agcagcgcgt cgtagacccg ggccgagtgc ggcttgctgg tatcgatcgg ggggtgaggc
     4081 gcctgtgccg tcataccgaa ctccagatac acgtggtgtg gaccattcag tcgacgcagt
     4141 ctgccacaac gcctacgggg tgccggcggc cacccagtgg cccaccagat ccgcgtagag
     4201 cgggctctcg cccaggagtt gggcgtgtgt gccgatggcc gtgcgctcgc cgtcgagcac
     4261 caggacgcgc ggcgcgcgca gcgcggagct gatgcggtgc gccaccacga cgagcgtggt
     4321 gccccgtgcc gcgaacgccc gctcggcccg ctcctcggcc gccgggtcga ggtggcagca
     4381 cgcctcgtcc agcagcacga ccgacgcggg tgacacatgg gcgcgggcca gcgccacgag
     4441 ttgccgttca ccggaggaga gcggggggcc gtccagcccg acgggtgcgt ccaggccgcc
     4501 gagccggtcc acgagggccc gcgcgcccac ggcctccgcg gaggcgagga ggtcggcgtc
     4561 ccgggcccgg ggggtgaggt agcggaggtt gtcccgcacg gtgccggtga acacgtacgc
     4621 ctcctgcggg atcaacgtca cctcccggtg gagccaggcc cggtcgacct ccgtcaccgg
     4681 cacgccgccc agggtcagcc ggccgtcgtc cggtgcggcc agcccggcca gcagggtggt
     4741 cagggtcgac ttccccgcac cgctcggccc gacgaccgtc agatgggagc cggcgggaag
     4801 gtcgagggag agcccgtcga tgacgggtgc cgcgccgggc ccgtaggcgt agccgacgtc
     4861 caccagggac aggtccgggg agcgcggggt ccgtgcgaag gcgtccggcc ccggcgcccg
     4921 cgcgggtacg cgccgtgcgg ggatgtccgg ccccggcgcc cgcgcgggtg cgcgccgtgc
     4981 cggagccgtc gaccggctca accggcccag tacggtcgcc agctgcacgc cccacgagcc
     5041 gagtacggcg acgagggagc gcagggccgg agcgaccccg ctgatcagat agctggtcgc
     5101 gcccagcagt tcgcccaccg acagcgcccc ccggtccagg agccgcggag ccgccaggag
     5161 gagcaccagc agcgggaggt ggctgcccag tgacaccagc agggtgttgg ccgacgcggt
     5221 cctggcgacg gcccggaccg catcgcggtg gtcggtgatc cgggcggaca ggtcgtcggc
     5281 cacccggtcc cgggcgccgc acgcgacgac gtcccggatg ccgtcgaagg tctcccccgc
     5341 cgccgccgtg agcgcctcct cggcccgcag ttggcggccc tggcggcggg cgaggacgcg
     5401 gagccggggg acgcagagga gcagggtgag caggaccggg ggcagggtga ccgccgccac
     5461 cggcgcggac agggcggcga ggcccacgaa cgccatcagc agggagacgc cgagctgccg
     5521 ggccgagcgc agcagggcgg agaccagcgc ccgtacggtc tcgacctgga ccgtcagccg
     5581 ggccacgccc gcgcccgccg tgtcccgcgc tcccgccgcc gcgcgatgga cggcccctgc
     5641 ggccacggct gtcaccagtt cgtcccgcag cggctccacg agccgtccca gccagggggt
     5701 cagggtccgg gtcatcaggg cgcggaagac catcgcggcc ccgagcaggc cgatccagag
     5761 gaagccttcg gccgggcggc ccgccaggaa gccccggtcc agggcggcgg ccacgaggag
     5821 cccggaggcg agtgccggaa cggcctccag cagcgaccat cccgccaccg cgaccgccgc
     5881 accgcggtgc tgccgcagga acccggcgaa caggtgccgg tcgacggggc gcggggcgct
     5941 ctcgctcatg ccgactcccg ggtgtgcgga tccgtgccgt gcccgggaac gccttccggt
     6001 gcggtgtccg tcgcgaagag ggcccggtag tccccgcgtt gccacagatc cgcgtgcgtg
     6061 cccagggcgc ggacccggcc gtcctccagc caggccacca gatcggcccg cgccgcggtc
     6121 gacacccggt gggcgatcag cacgcgcgta cggcccgacc aggccgaggc cagcgcggag
     6181 ccgacctgtg cctccgtggc ggtgtccagg ctcgacagcg cgtcgtccag gacgaccacc
     6241 gccggatcgt ggaccaacgc gcgtgccagt ccgaggcgtt ggacctctcc gccggacagg
     6301 ggcgcgtccc tgagaggcgt gtcgtagccg tgcggcaggc gggcgatgaa gtcgtccgcc
     6361 cgagcggccc cggccgccgc cgccacctcc tggcgcgagg cgtccgggcg ggcgaaggcg
     6421 atcgtcccgg ccaccgtcgt ccccagcagc gcgggccgct cgaaggcgta gccgacggcg
     6481 gcgcgcaggg ctcggggagt cagttcccgc agcggcacgc cgtcgatggc gaccaggccc
     6541 gcgtcgggct cccgcaaccg cccgaccagc gccgccagcg tgctcttgcc cgccccggac
     6601 cgcccgacca ccgcgagcgc cgtgcccgcc gggacgacga ggtccacggc gtccaggacg
     6661 agccgggtcc cggaacgtac cgtcaccccc gacaaggtca ccgtgccggg gccggccgcc
     6721 gggcggctcc gggtgccggg tgccgggacc ggctggtcga cgacctcggc gacccgtcgc
     6781 gcaccggcgg ccgacatgcc gagcgcgaag agggcgtcga gctggtccag cgcggccatc
     6841 gcgagcgccg tgtacgcgac gaccgcggcg agttcgcccg cgctgatgtc accgtggagc
     6901 agggcgagcc ccccggcgca gagcaccagc acctccacgg ccgggatcag cagccccacc
     6961 tgccatccgg tgtcccgctg gagcgcccag acccggtgcc cggtgcggga cagctccggc
     7021 aggggttcca ggacccggcg cgtctcggcc gccgccgtgc cgctcgcacc gatggtccgg
     7081 gccccgccga gcgcttccag cagcagggcg gagatcctgc cctgggcctc ctggtaccgg
     7141 aggaagagcc ccgatccgcg gttcatgaac ccgcgggcga tgagcaccaa cggcggtacg
     7201 cccagcgaga agcagagccc gatccgccag tcgagcagcc agagcgcgac caccccgccg
     7261 agcgaggtca gcaccgcggc cgaggccgtg accagcgtga cccccgccga tccggcctgc
     7321 gcgcatccgg cggagagccg ccccgcgaga tccccggccg cgaagtccgc cgtccccggc
     7381 acccccgcgt ccagggcgcg ccgtgccagg gaccggcgca ggacggccac cgtgccggag
     7441 ccgtaacccc cgttggcgag ggtctggagg gccccggtgg tgacgacgag ggccaggagc
     7501 gcggcgcaca cgaggacggg accggtggcg ggccgccggg cgacgaccgc gtccagggcc
     7561 cgcgccatgg cccaggggaa cgccagcgtg ccggccgatc ccaggacggc ggtggcggag
     7621 gcgagggcga accagccacg cgtccgggcg gtcgcgtccc acaccagtcg ctggggagac
     7681 gtcatcgcgc tccttccggc cctccgtggc tcccgcgcgg gcggccgggc acgggttgcg
     7741 gtgagtcgtg cgtacgggga tcgaaggggt gcacgcggcg gacaccggca tggggcgtac
     7801 gcgcggacac ggcgtgcgcc ggacaggccc gcggggggtc cgtccggcgc acggctgcta
     7861 ctgctgctcg atgctggtga tgctgcaggt ccaggtgcac gtacgggtgc agccggccag
     7921 cgcgacggac tcctcgccct ccagggtctg cagctcgtcg acgtcgacgg tcatggtgtt
     7981 gtcgatcatg atggtgtcct ttcgtcgtgc gtgatgtgcc cgaacaccgc cgaggatggg
     8041 cggtgccgca cggccgcgtc ggcgaccgtg agtccagggg gagcggggga gcggcggcgg
     8101 tccgggaatc cggccgtcag gaagctcacc agccggtcgg tgagttcggc gccgccccgc
     8161 tcctggagcg ggtggtggcc cgctcccgcg atgtcgaggc agtcgtgggg tgcgcgttcc
     8221 gggccgcccg ccgccgtcag cgcccggcgg agcctgtgtg tctcgtccac cggcacgacg
     8281 gggtcgtcgc agccgtgcag ggcgagcacc ggtacgcgga tgcggtgggc gaggcgttcg
     8341 acgtcccggg ggccgaggtc gtcgtccggc ggctcgccca ggccgtgccg gtcgatcagc
     8401 gcgcgcacgg cgggcgacga ccgctcgcgc agtccgcgcg ccgacaggaa cggggcgatc
     8461 accgcgcagc gtgcccaggt gtacgggtcg gcgcacacgg ccagcagggc gaggaagccc
     8521 ccgtaactgg tgcccagcag cacgggtggt tcggcgccag gagggcgctg ctccgtgagc
     8581 gtacggacca ggacgcggat gtccgcgagg tcgggcacgc cccacgcgcc gtggatcgcc
     8641 tccgcgtggg cccggccgta gccggtgctg ccgcgctggt tgggggccac caccgcggcc
     8701 ccggcctccg acaggcgcgc gagcaccggg tcgtggccga gcgtccagtg gtcctccggg
     8761 ccgccgtgca gcgccacgac gacggtgggt gcggtgcgcc agtcgcccag gcggaccgcc
     8821 tcgaaccgcc cggacggggt ggcgaaccac tcggtggggg cgtgcggggt cccggatgcg
     8881 tcggagggcg tccccagggt gccggaggac gacctctggg tgccggaccg ggcctcgcgg
     8941 gtgtcggacg cgggttcgta cgcggcgtcg taccgggcgg ggtgcgtggc ggtgcccggg
     9001 acggtgacca ggtcggcggg acggtccggg gtcgcgtaca cgacgcgcag cccgcccgcg
     9061 ctccagccgg cgacggggtg gaacgcgccc ggcggcagct ctgcgggccg gggttggtcc
     9121 gcccccacgt cgtacaggaa gaggcgggcc tgcgcgcccc gggagacccg cagcgccacc
     9181 cgctcacccg ccgggtcggc ggccagcgga aggaccgcgc cgtccaggga gttgagccgg
     9241 tccgggaagt cgagccgggg ccgctcgccg agagtggcgt gggcgatccg cagccgcccg
     9301 tcgccgggat cgcccgccgt cagcagcagc cccgaggccg gtgccgagag cagcagccgg
     9361 tggacgcggc cgttcgccgg ggacgggagg gcgtgccacc gcccgtcgcg caggtcgagg
     9421 gagacggggc ggtgtccgtc cggcccttcg aggtccgtgg cgtagcggca gcccgttccg
     9481 tccagcggca ggagggcggt cacccggccc ggcagggtca gtggatcgct cagccgcagt
     9541 ggcgcgggaa ggacccgcca gacgcgggta cggccgtcgt gagcggtctc caccgccagc
     9601 gcgagtgtcc cgcgcgggcc gccgggcacc agtcgcaggc cgcgcgcccc gacgggcagg
     9661 cgctcggccg ggtcctcggc cgggcccctg gccgggggct cggccgggtc ctcggccggg
     9721 gacagggact cggcgggcga cagcaggagc agatggcggc cggagcccgc cgcgccacgc
     9781 agtcgcagca gcccgccgtc ctcggtcggc agtacctggg tggcggtggt ctccgccggg
     9841 gcgccctccc ggtagcgggg cgtgccaccg gcgtacggcg ggcgcgtgcc gtcgaggtcc
     9901 caccaccccg gggccggcgc gccgtcggcg gtggccacca gacaggcggc gaaacgggac
     9961 cgtgccgaga agcggaagct gatgcgctgc gggtgccggt tcatcgcgct cccaccgccg
    10021 tacgcgggtg ccgcccggcg ggggcgaaga ggtccggggt gtccggcatc cagagccgcg
    10081 ggcccccgtc ccgcaggcgc agcagcatgc cgaccgttcc ggcggcaccg gtctggtagc
    10141 cgcccgtgac cgcctccagc gattcgtcgg gcaccaccag caggccgtcg cgccggacgg
    10201 cgcgggtgtg gatgcacgcg gccagctccc cggcctgctc gcggtaccgg gggtcgccga
    10261 gcgcggcgga catgtcgagc aggaactccg cgttcccggc gagcccgtga caggcggcgg
    10321 gcgaggagag ccacatggca tcccgtactc cggccgccgc gcccacggcc gcctcccggt
    10381 accgttcgtc gcccgtccgc gcccagagcc ggaccaggaa cgtgccgatg cccgaggagc
    10441 cgctgcacca gtgcgtctgc cccaccggcc cgtcggcgtc ccggtccccg gccggccaga
    10501 ccgcccggcc gtcctcgacc cgggccagcc tcaccagggt gtcgcccacc gcacgggccc
    10561 cctgcaggag gcccgcgtga tccgccgcca ccccggccgc cagcaggaac gcgccgatcc
    10621 ccgcgatgcc gtgggcgaac ccgtagtggc gggccccggc gaggttcgag tcgaaggcgg
    10681 ccggcaccgg ccagatcacc ccggacgggt ggtcctcggc cgcctcgacg atcgccccgg
    10741 cgcaggcgac cgcccggtcg cggaaagccg gatcaccggt cgtgcgccag aagtgcagct
    10801 gggtcatccc ggcccccgcc gccccgtggc agatgtcccg gttgggccag tcgacgggga
    10861 ccgcgcgcgc cagtgcggac gcctcggcgg cgacgtcctc gtcgcccagc agcagcgccg
    10921 cgtcgagcag tgcccaggcc gtgccggagc ggccgaagtg cagcccgggc aggagcgttc
    10981 cgtcgggtgt ccggccggtg ggaagatcgg cgaggcgccg ccgtgtccac tccgtcagct
    11041 ccgccacccc gtgccggacg tcgggccccg cgcccgccgc cgcggcccgg gtgagcacgg
    11101 ccaggacgcc ggccgatccg tactggacgt tcagcgggtc ggtggtcgcg ccgaacgagc
    11161 tgacgtccca gaggtgtccg ccgctgccgg ggcgggtgcg gagcagatac gcgaggccgt
    11221 cggcgatcag ccgttcgcgc tcctcgtcgg ccagggccgc aacgccgctc ccaccgccgg
    11281 cgcccgggcc cgtcaccccg gttccgcccg tgggccggtg accggttccg cccgtgggcc
    11341 ggtgtccggt tccgggcagc tccgcgagaa ccctccgtac ccgggacagc tcccaacgtc
    11401 cttcggggag cggggcgcag agggcgagca gcagaggcag aagcggggcc gcccaggggc
    11461 ggtcggcgat cgccagtgcg atcagggcct ccgtacggtc gcccaccggg cggccgtcgg
    11521 ggaccaggag catgtcgaca cccgtcgcca ggtggagcag caccgcgccg aggccgtaga
    11581 ggtcgcccgc gtacgtgggg gccgtgaagt cgtagtcccg cagcgaggac acctcggggc
    11641 cgacatagcc gggggtgtac ccgcggcgga ccgggacgcc ctcgggggcc aggtactcga
    11701 cgtcgatgag ccggacccgg ccttccgggg tgaccatgag gttgttcggt gagaggtcgc
    11761 gcagcacccg cccggtgccg tggacgcccg ccacgatgtc cacgatctgc cggccgaggt
    11821 gcaggaactc cgcgaggtcc cgcaccgggc gctccaccag ccggtcgcgc agcgtccgcc
    11881 ccggcacgaa ctcctgggcc aggaagaggt tgccgccctg cgcgaacaac tcgatcgcgg
    11941 caggggtgca gcccagcggg gccagcgcct ccagcatctc ggcctcgtgg cgcagggtgt
    12001 cctggaggtc ggtgccgtcc atgcggacgc cgacgtgcgc ccgcgcctcc ttcaccacga
    12061 cctgccggcc ggtggtctcg tcggtcgcga ggtacacccc gcccttgaag gcgtgccgga
    12121 tcgccttggc gacgacgtaa cggccgttga ggcgaacgga tttcctcccc ggtgtccgcg
    12181 tcggctgccg cggtccggtc tgctccagcg gtccggtctg cgcccgcgac gggttcgacg
    12241 tggcccccgg gggagacgtc ggctccggga acgggggcgg tgcccacgcg ggggtggtga
    12301 cccaggcctg acgccggtcc ttctccagtt caccggcggg gttgcgcagc cgtacgtccg
    12361 tgtccccgtc gttcgtcgtc gtccgcaccc cgccgaacac cccgtagcgg tagtggacga
    12421 ggctgcccgg ggcgtacggc tggtccgaca ggatgcgggg tccgcgcagc cccagcgtcg
    12481 ccgcgtggag ccgccgggcc agtcggcgga acagctccgg gtcgtccggg tagaccgtga
    12541 tgaactttcc gccgcccccg cggtcggcgc gcccgccggt cagcagggcg acccggtcca
    12601 gggagccggc gaacttgaac gaggcccgtt ccccgatgag gacgtcggcc gccaccgcga
    12661 gcaccagggc cgcggacagc ggtgtggccg acaggtgcag tttccagccc tgttcgccgc
    12721 tccgatggcc gcggggccgg accgagcacc agaactcccc ctgatcgacc gcccacccgg
    12781 tggcaccgcg ccggtgcagc acgccgtcga cgatgccggg cagcagtccg gtgtccagcg
    12841 cgaagaagct gccgctgtcg tgttcgtcgc agtccgtgct cacgggcgat ccttcctgtg
    12901 cggtgcggtg cggagccggg ccatgccgtg cggtgcgggt ctgtgcgctg ggcgcttcgg
    12961 gtccgcgtcg ggggttggcg gcggccgaat caggtggcga tgcgtcacat cgcttttcag
    13021 ccacggcgga tcgaaagatc tgccgagttg tccgggaatc acaggccgac ctcggccggg
    13081 gtccgcctat cgtggccgcg agcgatcccc tgatcgccac gggtgacgtt agcggtgtgc
    13141 cgaggggccg gtgcaccacc cgttctgggg ggttgtgatc aaggggggcc gccggatcga
    13201 cagagccgaa accgggctgc aacgggcccg gaagacgatg gtcatcgcca ccgcgctgta
    13261 ccgcggcagt catctggtcg cgggaggttc ggtggtcacg cagcatcagc gcgaccgtcc
    13321 gttcccgtgg ctggcgctgg tggccgcgat cgcggcgacc gctctcatct ggttcatggc
    13381 ggcccgccac cggcggctcg tctcctgggc ggtgggcctc gacgtcctgg tgatcggctg
    13441 cctgctgccc ttcggcgcgt acgtctgggg aggggcccgc actcaggagt cgatcgcctg
    13501 ggtcatgctc ctgggcggat cggcctcggc catggccgct gtcgccttcg gagcgcgcct
    13561 cctcgccgtc gccgtggtgc tcctggtggc cacgcatctc gccgggtatc tcctggtgga
    13621 ggcggacgcc gccgtgaccg gcgcccatct gaacgccctg gtcttctccg ccgtcgtctc
    13681 ctgggtgctc acctggtacc tctgccggca gggcgagcag gtcgacgcgg ccaaccggcg
    13741 tgcgctggac gcggaggcgc agcgggcccg gttcgcggag cgcgtcgccc accacaacgc
    13801 cctgcacgac acggtcctcg ccacgctgac ggccatcgcc cgcggtggcg tcgacgccaa
    13861 cacctcgatg atgcgcgagc ggtgtgcgcg ggaggccgcc tacctccgga ggctggtcga
    13921 ggaggcggac gaccgtgagc acgcctccga ggtgcgggcc gcactggagg agtccgtacg
    13981 cgcggccgaa gcgctcggac tgcgggtgac cgcccgctat cacgcgctgc ccgccgtgcc
    14041 cggcgagata gcgctgacca tggcacgggc cgcgaccgag gcgctcaaca acgtgcggtg
    14101 ccacgccggt acggggcacg ccttcctgac cgccgccggt gactccggcc ggctggtcgt
    14161 caccgtggtc gaccggggcc ggggattcgc cgtggaaggc gccggaaggc agggagcgag
    14221 cggaccggcg ggggcggagg cgtcgggcgg gtcggtggtg cgcgccgcct ccgtcccacc
    14281 ggccaccggc gggatcgggc tcgaccgttg cgtgtacgcc cggatgcgcg gcgtgggcgg
    14341 gcgggccctg gtggacagcg cccccggcga gggcgtgcgc gtggagctga gatggccggg
    14401 gtgatcagcg tcgccgtggt ggacgacgac cggatgctgc gggacggcat ccggtcctgg
    14461 ttcgcggacg tcgaggaggt ggacctcgtc gcctgcgccg ccaccgtcga cgagctgctc
    14521 gccgggcacg gggagccgcc ggacgtcgtg ctgctggacc tcatgctgcg tgacgaccgg
    14581 acgtccgccg acaacatccg ccgcctgcgg acggccggca gccgggtgct gatgatcagc
    14641 gtggtggcgg accgcgaccg gatcgtcgcg gccgtcaccg acggcgccga cggcttcctc
    14701 acgaaggacc aggaactgtc cgtactcgtc gaagccgtcc gcgagatcgc ggccgggcgc
    14761 accgcccact ccccggagct ggccttcgcc ctggcctacg accggggccc ggcccgcccc
    14821 cggctctctc cgcaggagcg cgaggtgctg gtggggtacg cctccgggct gacgctgaag
    14881 gccacggccc gcaggaccgg gatcacggtg aacacggcga agtactacct ggaccgggtg
    14941 aaggccaagt accaggaggc gggccggccc acctacacca agatcgacct ggcgacccgg
    15001 gtccgcgagg acggctggcg ttgacccgta ggcgtacggc atccgaggat cgctgacgtg
    15061 agccatcctt ctgatcagcc ttcgtcttct ccgtcgccct cgccctggtc gccgccctcg
    15121 ggcgatgcgc cccgcacgga cgggccgccg ccctcgccct gggccccgcc gtcgtcggcg
    15181 gccgagccgc cgcacccgcc cgcagcggcc tggcagaccg gacaggcggg gcaggcgtgg
    15241 ccgggcggcc agggctggga ccggcccccg gagtggagcc gcccgccgac cgggccggag
    15301 cgggctccct ccgggtcccg ctacgacgag caggggcgca acgggcgcgg cggacggttc
    15361 ggctggatcg gtgagctgtc ggccgtcgtg gggctggtcg tggcgggcgt cctggtcgtc
    15421 agcatcggcg ggttcgtcct cgcggagctg ctggacgcgg ggcccacgga cccggacagc
    15481 gacctgttct tcgaggaccc cgtcgccgac ctggtcgtcc agctcctcgg catcgcgatc
    15541 gccatacccg tcgtcctgtg gggcgcccgc gtgatcggcc ggcggcccgc cgggaccgtg
    15601 tcctccgtcg tcgggcggct gcgctggggc tggctcgcgc ggtgcgccgc cgtgggcttc
    15661 ccgctgatgg tcgtgcagat cggcgtgctc atcgcgtgga cctggaacga cgagccggtc
    15721 ggggagtcgg ggaccggctt cccggggtgg tccgtcttcc tgctgagcct ggcggtgatc
    15781 ctggcgctcg tcccgttcca ggccgccgcc gaggagtacg tcttccgggg ctggctggtc
    15841 caggtgatcg gccgggtcgc gcggacgccc tggcccgccg tcgccgtcgc gtccctgctg
    15901 ttcgccctgg cccacgggtt cggtgaactc tcaggattcc tcctgctgct gtactcggcc
    15961 ctgtggtggg gctggctcgt gatccgtacc ggtggactcg aagccgtgat cgtcatgcac
    16021 gtcgccaaca acctgctggc cttcggcctc gcggccggct tcggcgaact cgccgccacc
    16081 gagaccgccg ccgacgcccc ctggcaggcc atggtcgccg aactcgtctt cgccccgctg
    16141 tactgcctca ccgtggcccg catcgccgac cgccgcggga tcgagcgggt gagcccctga
    16201 ccacctgacc ccctgacgcc ccgggaccac agcgctgccc ctcacgtcgc gttcagcgcc
    16261 accgtcgggt gcaggcgcgc cgcccggatc gccgggtaga ggcccgcgac cacgccgatc
    16321 agcagcgtcg ccgccaggcc gcccgccagg gaccagggcg ggaccaccgc cgtccacccc
    16381 tgcgcccgcg cgaacccgta cgtcgccgcc gcgcccagca gcgcccccgt gaccccgccc
    16441 agcgcggaca gcagcagcga ctcggtcagg aactggagcc ggatcgcggc gcgcgtcgcc
    16501 cccagcgagc ggcgcagccc gatctcctgg cggcgctcca gcacggagat gaccatcgtg
    16561 ttggcgaccc ccaccccgcc caccagcagg gccaccgcgc ccagcccgag catcagggcc
    16621 gtcagcccct tgtcggccgc cgcccgggcc gccagcgcgt ccgaggggcg cgagacccgg
    16681 acggcggcct cgttgccggg gctgaccgta cgggccagca cctcccgtac gtcctcgacc
    16741 gacgcgtccg tggagcgctc gaagaccgtg gtggggcggc cgtcgaagcc gaagtaccgt
    16801 tcggcggccg ggaatccgac cagggccacc cggtccagcg tcgggaccag ctcgacgggt
    16861 tcgaggatgc cgacgacggc gacccggacg tcgttcatca tgatcgtctc gccggggcgg
    16921 gtgacgccga gccggtccgc cgccaccgcc cccaggaccg tcgtcggcag ccgctccccg
    16981 gccggggtca gccaggtgcc ccgggcgacc tcgccgccga gcgtggcgag cagatccgtc
    17041 cgggccgcct gcgtggtgac cccggcggtg cgctcctcgg ggacgacatc gctgcggcgg
    17101 acacgggcgt cgacctcggc cgtggccgtg gcgtgcagca ccgggccgat ccgctcgacc
    17161 atcgccaccg cgttcttcgg cagctccacc gtgcccccga gcggggtctc gcccgcctcg
    17221 gcggtgagga ggttggtgcc gaggcggtcg aggcgggaca tcaggtccgc gcggctcgac
    17281 tcggacaggc cgaccaccgc gaccatcgtc gcgatgccga tggcgatccc gagcgccgag
    17341 agcaccaccc gggcccggcg cgcccgcagg ccgaccgcac cgacgcgcag gacgtcccgg
    17401 ggggagaggc gtgcgggctt cagtgcgtgg gtcatgcgcc cgcctccgta tcgtccgtac
    17461 gggccccatc gaccgtcacg ccgaatcctg ccgtcgtgct gcggtcgtcc gacacgatct
    17521 cgccgtcccg gaaccggacc cggcgcggca gcgcggccgc gatctgctgg tcgtgcgtga
    17581 tcacgcagac cgtcgtgccc gacgcgttca gctcgtgcag cagctccatg acgatcgccc
    17641 cggacgcggt gtccagcgcc cccgtcggct cgtccgccag cagcagccgg ggttcgccca
    17701 ccagggcgcg ggcgatggcc acgcgctgct tctcgccgcc ggacagctcg ttcggggtgt
    17761 gcgaggcccg gtggtccagg cgtacgcggg ccagcgcgtc gcgcgcccgc tcgcgccgct
    17821 cccgggagcc gacgcccgcg tacagcagcc cgtcggcgac gttgtccacc gcgtcccggc
    17881 ccgcggccag gtggaagtgc tggaacacga agccgatgtg gcgggcgcgc agcgcggaga
    17941 ggcgcgcgtc ggggagcgcg gacacgtcgt acccggcgac ccggaccgta cccgtggtgg
    18001 gcctgtccag ggtccccatg acgttcagca tcgtggactt gccggagccg gacgggccga
    18061 ccaccgcgag gagttcgccc tcgtggacgg tgaggttcac ggcgcgcagg gcgtggacgc
    18121 cgccggggta ggacttggtg gcgttccgga gttcgacgac gggggtgggc gggggcgcgg
    18181 tgacggccga ccgggcctgc gggggtgcgg tgacggcggg ggccggccgg ggcggcgggg
    18241 gtgtgctcac tgcttcgcca cccccacctt catgcccgcg cgcagcccgg ctccgctgac
    18301 ctcgatccgc ccgtccgccg tcatgcccgt ctcgacccgg atcatctcgg acgtcccgcc
    18361 cttgacgacc tggagcccgt acccgccgtt ctcgccgcgc agggcgacga ccgcctcgac
    18421 cggcaccgcg aggaccccct cgcgggcctc gctgacgaac gtgacgctcg ccgccgcctc
    18481 ggcgtcctcg ccggacgcgg cgcgggagcc gccgtcgagg acgacctcga cggtgatgcc
    18541 ctcctggccg ccgccctcgg tcccgtcctc cccttccggg cgtaccgtgc cggcgacctt
    18601 cccgggcacg gtcttcccgc tcggcagcgt cacctccacc ttcgtgccgc gtgcggtgag
    18661 cgcgccgtcc gtctgctcca ggacggcccg gacgaccggc ctggtggagg cgatcgtcag
    18721 gacgggtgcg tccgggccga cctggtcggc gagggccgcg tcggcggaga ccaccttgac
    18781 ctcgccgggc tggaagacga catcgccccg gccgatccgg ccggtggtct cgcggttcag
    18841 gtgcttctgc cagcgcttga cggctgactc ggtgtcctcg ccgtactccg tgtcgacgta
    18901 cagcccggct ccgtaaccca ggtcccgcag gttccgctcc agttggagta cgtcgctgcc
    18961 ccggtggccc ttcttcatct cgcggaacgc cgggaccggc ccgtagagga gcgtgaccgg
    19021 cttgtcgttc agctcgtaca gggcctcccc gcgccgtacg gtccttccct cggcggccgc
    19081 caccgtgacc gtgccctcca cggcggcctt cacggcccgg cgctgggcga agtcgatcct
    19141 gccgtcgacg gttctggcga ggacgaggtc ggtgcggacg acggtggcgg tggcgggcgg
    19201 caggccgtca ccgccccggc ccgggcttcc cgttccgtcg cccgcgccga ggaacaggac
    19261 gcccccggtg acggccgccg tcaccgtgcc cagcgcgagg agggcggtgg tggagcgctt
    19321 cactgcatcc cgtccagtcc gtcgaggagc ttctccttgc acgcctcgcg ggcctccttg
    19381 tacgcgggcg actcgcggtc gtagacgggg gagcccgggt tcgggtcgcc gcccggtatc
    19441 gcgttgccgc cggacatcac cgggttggtg aaccggctga tgccgttgtc ccgcatgcac
    19501 tgggcgtgcg cgagcatcga ttcgtaggcc ttctgctggt cgcgctcggg ctcggccgcc
    19561 atggccgcct ggagctccgc cacgcagacg ccgttcttcc cggccttgat gccttcgttg
    19621 cggccgggcc gggacccgat ctcgttgatc ttcgtccagt cgagatggcc actgagcttg
    19681 gggtccgggt agtccttgta gccgcccttg gagcgcatgc actggacgaa cgccacctgg
    19741 gcgtcgtaga aggcgctctt gccggcgggc ttcgcgctcg gggaggtctg ttcctccgcg
    19801 ttcccgtccg tggacggctc ggtcttcggg gacggtacgt cggcgatcgc gtcgtggctc
    19861 ctggtcccgg tggcgtcgtc gctcccgccg caggcgacgg agagggcgag cacgggcacg
    19921 gccacgaggg cggccaggcg gagcccggct gtggtggtgg ggaagctcat ggatctcacg
    19981 ctggccgccg aggatgatgg ccggtccatg ggcacatgat gggaacgtaa caatgcctcc
    20041 gacctgcgcc tgtgccccag ggagggggag gcggggacgt tccgggcgtg cgcataatcg
    20101 ggcccatgcc gcatgtgctg ctcatcgagg acgacacgtc cgtacgggac gggatggagc
    20161 ttgtgctgcg ccggcacggg tacggcgtgg agacggccgc caccggcgag gaggccctcg
    20221 cgctgctcgc cggggagcgg ggcgcccggg tcgaactggc cgtgctggac ctgatgctgc
    20281 ccggcatgga cggcttcgag gtgtgccgcc ggatccgggc ccgtacggcg gccctgcccg
    20341 tcatcatgct gaccgcgcgc ggcgacgacc gggacatcgt ggccgggctt gaggcggggg
    20401 cagacgacta cgtggtcaag ccggtcaccg cgcccgtcct ggaggcccgc atccgggcgg
    20461 cgctgcggcg cgcggaaccg tcactgcggc aggggcccga cgccgacgtc accgacctcg
    20521 ccgggctcgt gatcgaccgg gccgggctga ccgtgacgag gaacggcatt ccggtcccgc
    20581 tgccgccgac cgaactgcgg ctgctgctgg agctgtcggc ctcgccgggc cgggtcttca
    20641 cccgggagca gctgctcgcg tcggtgtggg accacacgtt cctgggcgac tcgcggctgg
    20701 tggacgcggc ggtggggcgg ctgcgggcga agatcgagga ggtgccgggc aagccccggt
    20761 acgtgcagac cgtgcggggc ttcggctacc ggttcgggcc gctgtgacgg ggggcttccc
    20821 gggcttcccg gggcgtgggg ccctccggcg cggagcccct cggcgtgagg cgccccggcg
    20881 cgggtctccc cggaacgggc ccgggcggcg tgaggccctc ccggacgggt ctccccggcg
    20941 ccgctccctc cggctcgggt cccggcggct cgtcggcggg ctgcgggtca ggctcgtcgt
    21001 cacgttcgtc ctggtcgccc tcctcagcgc ggtgaccgcg accgccctcg cctaccggga
    21061 cgcccgcacc gccatcctcc agcgcaccca gaacaccgcc gtgaacgacc tccgcgagcg
    21121 ggtcgcgacg gtcgcggccg ggttcgacct gccgcccgac cagcgctcgc tgtcccggtt
    21181 cgccgcgcag gtctccgagg gtctgggcgc gcgcatcgtg gtcgcccgcc accaggacct
    21241 gaccgccgtc tccgacgcgt acgccgccac ggagggccgg atcaccgccg agctgcgcgc
    21301 tgccgtacgg gccggggacg gggcccggtt ccagcgggtc cagtggcggg gcgagccgta
    21361 cctcgtcgtc ggcatgccgg tgacgtacgc cgacggggac cggcgcacct cgggcctgga
    21421 ggtgttcgcg atcaccgatc tgcgggccga acgcgacgac acggcggccc tgctggactc
    21481 cgtgcgggag gggaccgtgc ccgtcgtggt ggcggccgcg ctgctggctc tgctggccgc
    21541 cgggacggtc ctgcgtccgg tacggaagct ggggcgggcc acgcgtgagc tggccgccgg
    21601 tgacctcggg agccgggtcg tggtccgggg gcacgacgaa ctggctcatc tggcacggac
    21661 gttcaacgag accgccgacg cactccaggc gtccgacgcg gagttgcggg cccaggaggc
    21721 gaaggcgcgg cggttcgtgg cggacgtgtc gcacgaactg cgcaccccgc tggcggcgat
    21781 gacgatggtg gcgacggtcc tggaggagga cgccgaccag ctgccgccgg acgccgcccg
    21841 ggccgcccgt accgtcggcg cggagacggc caggctgtcc cggctggtcg aggacctgat
    21901 ggagatctcc cgcttcgacg ccggtgcggt ccggctcaac gccttcgagg ccgacctcgc
    21961 cgagaccgta cgggcgtcgc tggcgctgcg cggctggacg gaccgggtga ccgccgaact
    22021 cccggaaggc gtcagggccg tggtcgaccg gcggcgcgtc gacgtgatcg tggcgaacct
    22081 ggtgggcaac gcgctccggc acggggcgcc gccggtcacg gtgaccctga ccgcgcccgg
    22141 gggcgacgag gaccgggtgg cgaggctgga ggtcgccgac catggtccgg ggctgccgcc
    22201 ggaggcccgg gcgcgggtct tcgaccggtt ctacaaggcg gacgaggcac gtacacggaa
    22261 cacctccacg gccgggagcg gagcggaggc cgacagggag tccggcggcc ggggcagcgg
    22321 cctcgggatg gccatcgcgc tggagaacgc caggctgcac ggcggcacga tcgaggtggg
    22381 cgaacgggcg ggcggcggtg cggtgttcac gctggtcctg cccctgcggc gtaccgatgc
    22441 ggacggcgag ggagagcgat gaggttccga gggggcgtcg tcctgaccgc gctggcgttc
    22501 ctgctcgtcg gctgcggggt cggggtccgg ccgaccggag tgatagacgc gggcgacccc
    22561 gcctccgggc tgacgcgggg gaaacggctc tactacgcgt cggacacggg gctgcgggcc
    22621 gtgcccctgc tcgaccggga gaacgacacc ctggacgcgg tgatgaagct gctggcccag
    22681 ggcccgacgg ccgccgagcg ccgcgagggg ctgaccaccc tggtccacgc cccgagcgga
    22741 tacacggtga ccggggacgg accgcacgtc acggtgacgc tggaggggcc gtactgggcg
    22801 cagccccggg accaggcgac cgggcaactg gtctgcacgc tggccagctt ccagtccgta
    22861 agggaggcgg agatccgggc gga
//
