LOCUS       NZ_KZ819178            21077 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. CS131 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ819178
VERSION     NZ_KZ819178.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS131
  ORGANISM  Streptomyces sp. CS131
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7968990)
  AUTHORS   Malmierca,M., Ceniceros,A., Mendez,C., Salas,J.A. and Olano,C.
  TITLE     Genome analysis of twelve Streptomyces spp. associated with Peruvian
            leafcutter ants
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7968990)
  AUTHORS   Malmierca,M., Ceniceros,A., Mendez,C., Salas,J.A. and Olano,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-APR-2018) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.88x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003116755.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 09:38:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,994
            CDSs (total)                      :: 6,912
            Genes (coding)                    :: 6,769
            CDSs (with protein)               :: 6,769
            Genes (RNA)                       :: 82
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 143
            CDSs (without protein)            :: 143
            Pseudo Genes (ambiguous residues) :: 0 of 143
            Pseudo Genes (frameshifted)       :: 41 of 143
            Pseudo Genes (incomplete)         :: 122 of 143
            Pseudo Genes (internal stop)      :: 12 of 143
            Pseudo Genes (multiple problems)  :: 31 of 143
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:40:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1073831
            Orig. end                         :: 1094908
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ819178.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Professor JA Salas
            laboratory.
FEATURES             Location/Qualifiers
     region          1..21077
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="9"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21077
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21077
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11077](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11077
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(599..1396)
                     /locus_tag="DBP20_RS04730"
                     /old_locus_tag="DBP20_04730"
     CDS             complement(599..1396)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007453202.1"
                     /locus_tag="DBP20_RS04730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04730"
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="WP_093439642.1"
                     /transl_table=11
                     /translation="MPSLRTALLQSSGRPGAVAENLKTLDEAAARAAGAGARLLVAPEL
                     FLTGYAIGDAVPVLAEPADGPGAEAIAEIAVRHGLAVLYGYPERDGERIFNASQLIGAD
                     GVRLANYRKTHLFGCFEQEWFTPGEQTVVQADLDGIRIGLLICYDVEFPENVRAHALAG
                     TDLLLVPTAQMHPFQFVAESVVPVRAFESQMYVAYVNRTGPEGEFEFVGLSCLAGPDGV
                     VRTRAGRGEELVIGEVDPEFLAASRAANPYLADRRPGLYGSLA"
     misc_feature    complement(1659..1679)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.0"
                     /tool="antismash"
     misc_feature    complement(2122..2142)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.49"
                     /tool="antismash"
     gene            2359..4995
                     /locus_tag="DBP20_RS04735"
                     /old_locus_tag="DBP20_04735"
     CDS             2359..4995
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024180.4"
                     /locus_tag="DBP20_RS04735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04735"
                     /product="CHAT domain-containing protein"
                     /protein_id="WP_162600156.1"
                     /transl_table=11
                     /translation="MALLARHELAGGREDLDNAVAALERAAAGIGDDHPDRDTVLSTLA
                     DALLCRHAQREDSADLLRAGELRYDVEQPPSFATARFAAYLSSGDPDALDEAVTMGVVA
                     VEQTRDPAQRAWSLNNLAGYLLARYQARRHPDDGAGAVDRLDSARELLRRGTTPYAVVS
                     LNLAHALVTGPAPRHRRALRLASEVLKTPQSPLTIQAQALELICSIAEFRVGRPSLPEE
                     FPEDLEMRLGALEERLYAESADARATSLRWARARLRREAGQREESRELAQDVLANRVWD
                     VLVQPDPAEAYRWAHRALDEAAEMATWLSADELSEEAFASVECARGLAVHAAAGTDPVA
                     ARLDALGSDDLRRRWLLARESTALPSSRPELRRELDAPAVTGQDLRRLRAEVQQALTTQ
                     GRAGSAVAGLLGQASPRELAEKVRAVGADAVVHLVSGRGSRPGLALILHAAGDVRALAL
                     PDLCETSEKLRRFALAHDLSLRSPGDRADSEWAKALRGLYGWTWQAVVGPLLEQLSSRP
                     ELTDRAVPQVVLVPTGILGLIPWHTARRKVGGPGWRYAIEDASFSYAPSVGSLKGFADR
                     APALLDGGGLVVADPSDDLPHARQEGGDLHRWYYAKGPRLGRSADPSTLPATPRAVLGA
                     LLPDTTPDAPAVAHFACHARSCAPAAESHLVLAGGQRLTVDALLRSARPTGSREGPLVV
                     LSGCATAVPGDRYDESLSLATAFASAGAASVVGTLWTVRDEVAAQLMTDFHHFLNLDGL
                     PAAEALRQTQLRALARARRRTKGGSAGARTKAEDPLHWGAFLHYGGGFSASSQPHPDPD
                     TEAGEGSGQTAGTRSPIFGRMPGRERSEVVWLCPEPGCAHRTSGDAKAPFDEDTCPWHP
                     RQALTRE"
     misc_feature    3166..3168
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4999..5988
                     /locus_tag="DBP20_RS04740"
                     /old_locus_tag="DBP20_04740"
     CDS             4999..5988
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DBP20_RS04740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DBP20_04740"
                     /product="hypothetical protein"
                     /protein_id="WP_109177899.1"
                     /transl_table=11
                     /translation="MGELVKGMVEPLAKRWTAAMSGPLVLFWLAGALLVAHGQGGLPGA
                     CDAGLWGIAEPACRLMDQGVWGAVLAGAAATAVMVLCALGLSAVASPLLEILAGRWGTW
                     PPVVTLALRCTNGHAARRERLDTRARDLSGPGDLVGDRLAVWRTQKAWRRTADRRKWSH
                     YPRRRDELRPTAVGNALHGAAAGIERNYGLSLPVCWGPFVECLEPTARERLIASATRVL
                     GRTQALVCAAAASVWVVAVPGSVARLCWLAGCALCVWGAYRSLRSGIEQYCEHVRDVFA
                     VHRIRLYRAAGIAPPPSTAEEVERGRLLTRALAMELTDEVVHVWPEAP"
     gene            complement(6000..6497)
                     /locus_tag="DBP20_RS04745"
                     /old_locus_tag="DBP20_04745"
     CDS             complement(6000..6497)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512479.1"
                     /locus_tag="DBP20_RS04745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04745"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_109177900.1"
                     /transl_table=11
                     /translation="MRLNDLDERIVHALAEDARRSYADIGAIVGLSAPAVKRRVDRLRA
                     EGAITGFTVRVDPAALGWETEGFIEIYCSRNTSPDAIKQGLARYPEIASASTVTGEADA
                     VVQVFAADMRHFEQVLERIAGEPYVERTKSVLVLSPLLRRYSAGAPDRSDPGVPEDASS
                     RS"
     gene            complement(6614..8071)
                     /locus_tag="DBP20_RS04750"
                     /old_locus_tag="DBP20_04750"
     CDS             complement(6614..8071)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015607337.1"
                     /locus_tag="DBP20_RS04750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04750"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_109177901.1"
                     /sec_met_domain="Aldedh (E-value: 2.5e-156, bitscore:
                     519.4, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTDLAHQYIDGEWRPGKGSWDIIDFNPFGGEKLASIPVATAD
                     EVDQAYRAAERAQQAWADTNPYSRRAVLEKALRIVEEREPEIGEAIVAELGGTRLKAAF
                     ELHLAKEFLREAIQLALRPAGQVLPSPTEGKENRVYRVPVGVVGVISPFNFPFLLSLKS
                     VAPALALGNAVVLKPHQNTPICGGTLLAKVFEDAGLPAGLLNVVITDIAEIGDTLLEHP
                     VPQVISFTGSDKVGRHVATVCAQNLKRAVLELGGNSALIVLDDADVDYAVDAAVFSRYV
                     HQGQVCMAANRILVDRSVEAEFTEKFVAKVASLTVGDPADPATQIGPLINSSQAESVSK
                     LVDQTVAAGATALLHGRADGNLVSPSVLTGLAADSPVLHQEIFGPVALLIPFDGEDEAV
                     RIANDTPYGLSGAVHTGNIERGVRVGQRIHTGMIHINDGTVHDEPIVPFGGEKSSGLGR
                     LNGDSMIEAFTTQKWISIQHGRSQFPF"
     gene            complement(8237..9703)
                     /locus_tag="DBP20_RS04755"
                     /old_locus_tag="DBP20_04755"
     CDS             complement(8237..9703)
                     /GO_function="GO:0003938 - IMP dehydrogenase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960551.1"
                     /locus_tag="DBP20_RS04755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04755"
                     /product="GuaB1 family IMP dehydrogenase-related protein"
                     /protein_id="WP_032768188.1"
                     /transl_table=11
                     /translation="MRFLEPGTGRYTESPAVPYDLTYDDVFMVPGRSAVGSRQGVDLSS
                     PDGTGTTIPLVVANMTAIAGRRMAETVARRGGLVVIPQDIPIEVVTDVISWVKTRHLVL
                     DTPIELAPGQTVADALSLLPKRAHGAGVVVDADRRPVGVVTEHDLSGVDRFTQLSEVMT
                     KDLVLLDADIDPRDAFNKLDGANRKLAPAVDADGRLVGILTRKAALRATLYTPATDAGG
                     KLRIAAAVGINGDVAGKAKQLLDAGADVLVVDTAHGHQESMISAVKAVRALDPQVPIVA
                     GNIVAAEGVRDLIEAGADIIKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEARKHGKH
                     VWADGGVRHPRDVAMALAAGASNVMIGSWFAGTYESPGDLQQSADGRFYKESFGMASAR
                     AVKNRTSDESAYDRARKALFEEGISTSRMFLDPARPGVEDLIDSIIAGVRSSCTYAGAG
                     SLAEFAEKAVVGVQSAAGYAEGKPLHASWS"
     misc_feature    9694..9705
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.23"
                     /tool="antismash"
     misc_feature    9703..9717
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.1"
                     /tool="antismash"
     misc_feature    9710..9719
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.15"
                     /tool="antismash"
     misc_feature    9711..9724
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.76"
                     /tool="antismash"
     misc_feature    complement(9712..9725)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.18"
                     /tool="antismash"
     misc_feature    9713..9726
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.15"
                     /tool="antismash"
     misc_feature    9714..9727
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.7"
                     /tool="antismash"
     gene            10001..11077
                     /locus_tag="DBP20_RS04760"
                     /old_locus_tag="DBP20_04760"
     CDS             10001..11077
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018960550.1"
                     /locus_tag="DBP20_RS04760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04760"
                     /product="terpene cyclase"
                     /protein_id="WP_093439650.1"
                     /sec_met_domain="T1TS (E-value: 6.8e-89, bitscore: 297.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSELPDIYCPFPQRTNPHVAHTREHLDAWTRRTGLVHRESARNR
                     FEQADFGAFVGMVYPTADEEHLDLVADWFVWLFLVDDQLDDGHLGRSPDRVRSVVERMR
                     AVVDGSAPGPLPGEDVPAAVTALADLWKRTTPNAAPHWRTRFAWHLVTYLTTATTWEAG
                     NRAEDVVPSEDTYIAKRRHTGAIHVCMDLIEIVAGIEAPESLHNDPRFITALEAACNHV
                     CWANDVYSFEKEQVLGEIHNLVHLVRHHRGLGEQQALDHVAERLAMETERFLTAEDELL
                     ELYPELSGLLVPYLDGMRSWMRGNLDWSRQTPRYNPADVGQYEEPEEYLEETVLGVPPA
                     RTEAAAPAPCAAKAPPAG"
     gene            complement(11148..12143)
                     /locus_tag="DBP20_RS04765"
                     /old_locus_tag="DBP20_04765"
     CDS             complement(11148..12143)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490194.1"
                     /locus_tag="DBP20_RS04765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04765"
                     /product="sugar-binding domain-containing protein"
                     /protein_id="WP_030589527.1"
                     /transl_table=11
                     /translation="MRMGPAELVQAAAMARRFYLEGKSKIQIAEEFGVSRFKVARVLET
                     ALERDLVRIEIRVPAELDAERSDALRARYGLRHAVVVESPAEEQDDAPDPENLGEVAAD
                     LLGELVAEGDVLGLAWGRSTIHMAAALDRLPPCTVVQLTGVYDAGTAERGSVEAVRRAA
                     QVSGGEAHPIYAPMLLPDPATAAALREQTGIARAFEYFDKVTVAAVSIGSWEPGISTVH
                     DMLSDEERAHYASLGVAAEMSAHLFDAEGRRVGRDLGERCITVEADRLRRIPEVVAIAG
                     GQRKAAAIGAVLRSGLVTSLVTDTAAADYLLTESAAGVRPALERADPDGE"
     gene            complement(12277..12960)
                     /gene="rpe"
                     /locus_tag="DBP20_RS04770"
                     /old_locus_tag="DBP20_04770"
     CDS             complement(12277..12960)
                     /EC_number="5.1.3.1"
                     /GO_function="GO:0004750 - D-ribulose-phosphate 3-epimerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rpe"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044795.1"
                     /locus_tag="DBP20_RS04770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04770"
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="WP_109177902.1"
                     /transl_table=11
                     /translation="MAQINPSILSADFARLAEEAKAVEGADWLHVDVMDNHFVPNLTLG
                     VPIVEALSKATDTPLDCHLMIEDADRWAPSYVEAGAGSVTFHAEAAAAPVRLAREIRAK
                     GARASMALKPATPIEPYEDLLPELDMLLIMTVEPGFGGQAFLDIMLPKIRRTRELISKH
                     GLELWLQVDGGVSAATIERCAEAGADVFVAGSAVYGAADPAAAVRDLRGLADVATAAAP
                     WACDH"
     misc_feature    complement(12947..12960)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
     misc_feature    13045..13057
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     misc_feature    complement(13048..13068)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.43"
                     /tool="antismash"
     gene            complement(13109..14542)
                     /locus_tag="DBP20_RS04775"
                     /old_locus_tag="DBP20_04775"
     CDS             complement(13109..14542)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512473.1"
                     /locus_tag="DBP20_RS04775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04775"
                     /product="transcription antitermination factor NusB"
                     /protein_id="WP_032780955.1"
                     /transl_table=11
                     /translation="MNDQPRRRPAKPHRRPKKDPVRFLAFEALRAVDERDAYANLVLPP
                     LLKKARAKGDFDGRDAALATELVYGTLRRQGTYDAIVAACIDRPLREVDPPVLDVLNMG
                     VHQLLGTRIPTHAAVSASVELARVVLGEGRAKFVNAVLRKVTAHDLDGWVEKVAPPYDE
                     DAEDHLAVVHSHPRWIVSALWDALGGGRAGIEDLLEADNERPEVTLVARPGRSTTEELV
                     KALGEDNSLPGRWSPYAVRMAEGGEPGALEAVRESRAGVQDEGSQLVAAALAAVPVEGR
                     DSRWLDGCAGPGGKAALLAALAAERGATLLAAEKQPHRARLVERALAGNPGPYQVITAD
                     GTRPPWLPGTFDRILMDVPCSGLGALRRRPESRWRRRAEDLEAFAPLQRGLLREALKAV
                     RVGGVVGYATCSPHLAETRVVVEDVLKGRGGEPVEAEWIDARPLLPGVPALGEGPDVQL
                     WPHLHGTDAMYLALLRRTG"
     gene            complement(14638..15570)
                     /gene="fmt"
                     /locus_tag="DBP20_RS04780"
                     /old_locus_tag="DBP20_04780"
     CDS             complement(14638..15570)
                     /EC_number="2.1.2.9"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004479 - methionyl-tRNA formyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006431 - methionyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="fmt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1228: methionyl-tRNA formyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490197.1"
                     /locus_tag="DBP20_RS04780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04780"
                     /product="methionyl-tRNA formyltransferase"
                     /protein_id="WP_109177903.1"
                     /transl_table=11
                     /translation="MKLVFAGTPEVAVPALDALIASDRHEVAAVVTRPDAPAGRGRRLV
                     ASPVAERAEEAGIEVLKPVKPRDEEFLARLREIAPDCCPVVAYGALLPKVALDVPARGW
                     VNLHFSLLPAWRGAAPVQHSLMAGDEVTGASTFLIEEGLDSGPVYGVLTEEIRPTDTSG
                     DLLTRLAFAGAGLLAATMDGIEDDTLHAVPQPHEGVTLAPKITVEDAQVQWSAPALRVD
                     RVIRGCTPAPGAWTVFRGERLKLIQATPVLDRTDLAPGELSAAKNNVYVGTGSHAVELL
                     WVQPQGKKPMRAADWARGVRIAHGELLGS"
     misc_feature    complement(15555..15569)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.72"
                     /tool="antismash"
     misc_feature    15617..15633
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     gene            15907..16473
                     /locus_tag="DBP20_RS04785"
                     /old_locus_tag="DBP20_04785"
     CDS             15907..16473
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010057355.1"
                     /locus_tag="DBP20_RS04785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04785"
                     /product="hypothetical protein"
                     /protein_id="WP_109181388.1"
                     /transl_table=11
                     /translation="MADHATHDAQARASLHLLVRDIERVRRQVDALRTLTAQLGNVYRP
                     RRSGPSAGFVVYGRAPAPTVRLAQELRDSVETLVTAAVDFDRSLGFSWDAVGSALGVTK
                     QAVHRRYGTRRATPQPAAETGGENTAVPRPVSVGSGLTGSSAKGSGSPVPTVPAARSMP
                     PQPSAAPQPAREELRPGAFPGPRNG"
     gene            complement(16566..18710)
                     /locus_tag="DBP20_RS04790"
                     /old_locus_tag="DBP20_04790"
     CDS             complement(16566..18710)
                     /EC_number="3.6.1.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0032508 - DNA duplex unwinding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044799.1"
                     /locus_tag="DBP20_RS04790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04790"
                     /product="primosomal protein N'"
                     /protein_id="WP_109177904.1"
                     /transl_table=11
                     /translation="MSSENEQSAEAGAGPPEQLALIRETVRRAKVPRAKPRTWRGAPLA
                     DDLPVARVLVNKGVLHLDQYFDYAVPQELDADAQPGVRVRVRFGAGGRNVQGGRREGGG
                     LIDGFIVERRADSDYQGALAALASVVSPEPVLGPELLALCRAVADRYAGSLADVLQLAV
                     PPRNGRAEAKPSPEPLPPPPPPDPGTWERYGQGPAFLRALAEGGAPRAVWTALPGPHWP
                     AEIAGAVAATLSSGRGALVVVPDGRAAARVDAALTETLGAGRHALLTAESGPEKRYRQW
                     LAVRRGSVRAVVGTRAAMFAPVRDLGLVVVWDDGDSSHSDDNAPFPHVREVLELRAAQG
                     RCGFLLGGTSCTVEAAQLVESGWALPLLADRERLRRAAPLIRTVGDGELARDGAARSAR
                     LPSLAWGAVRDGLRTGPVLIQVPRRGYAPRLACERCRTPARCRHCAGPLEAPDQQDLNC
                     AWCGQAERAWSCAECGSTRLRARIVGARRTAEELGRAFPAVPVRTSGRDHILDAVPDAP
                     ALVVSTPGAEPVAEGGYTAALLLDGWAMLGRPDLRAGEEALRRWLAASALVRGQEEGGT
                     VVVVAEPTERAVQALVRWDPAGFARRELADRAELGFPPVSRMASVTGPPEALAAFLQTA
                     GLPPEAEILGPVPAPSAAPGRARRPGDAPPGETWERALVRVVPGRGAALARALKTALAA
                     RTAKGANDPVRIRIDPPDIG"
     gene            complement(18861..20069)
                     /gene="metK"
                     /locus_tag="DBP20_RS04795"
                     /old_locus_tag="DBP20_04795"
     CDS             complement(18861..20069)
                     /EC_number="2.5.1.6"
                     /GO_function="GO:0004478 - methionine adenosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006556 - S-adenosylmethionine biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="metK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009187586.1"
                     /locus_tag="DBP20_RS04795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_04795"
                     /product="methionine adenosyltransferase"
                     /protein_id="WP_006123164.1"
                     /transl_table=11
                     /translation="MSRRLFTSESVTEGHPDKIADQISDTILDALLREDPSSRVAVETL
                     ITTGLVHVAGEVTTKAYADIPNLVRNKVLEIGYDSSKKGFDGASCGVSVSIGAQSPDIA
                     QGVDTAYEKRVEGDEDELDKQGAGDQGLMFGYACDETPELMPLPIHIAHRLSRRLSEVR
                     KNGTIPYLRPDGKTQVTIEYDGDKAVRLDTVVVSSQHASDIDLDSLLAPDIREFVVEHV
                     LAQLVEDGIKLDTEGYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMARHGGGAFS
                     GKDPSKVDRSAAYAMRWVAKNVVAAGLAARCEVQVAYAIGKAEPVGLFVETFGTAAIDT
                     EKIENAIAEVFDLRPAAIIRDLDLLRPIYAQTAAYGHFGRELPDFTWERTDRVDALRAA
                     AGL"
ORIGIN
        1 ccggttcatg tcggagaagt cggcgccctc ctccagacag gcgttccagg cctcggccac
       61 gtcgcggtag acctgcggca ggtcgtcgat ggtctcggcg tagtgcgact cgcccttgag
      121 gtccacgacg gtcgagggcg tggccgggga gagggggttg gggaagggcc gggtctgcag
      181 gcccaccagg tcgatgtagt gctggagcgc cgtggaggac ggcgggaagc gcatggcgcc
      241 catctcggcg gtgaggtcgc cgtcgcagcc gtcgaagccg acggtgcgca gccggccgcc
      301 gatctggtcg gcctcgtaga cgacgggctt gaggcccatc ttcatcagtt cgtacgcggc
      361 gatgatgccc gagagcccgc cgccgatgac ggcgacctcc tggccgtgct cggtcgccgg
      421 tatctgcccg aggccggccg ggtgggcgag gaagtcgtcg tacgcgtacg ggaagtccgg
      481 cccgaacatg gtgatcggcg gggcggccgc gtcggtgtgc tggacggcgt tgggcaccgt
      541 ggacgtcatg gggtacggac tccttgcgcg gtacgggtag ttcggggagg ggacgggctc
      601 aggcgaggga gccgtagagg ccggggcggc ggtctgcgag atacgggttg gcggcgcgtg
      661 acgccgccag gaactccggg tccacctcgc cgatcacgag ttcctcgccg cgtccggcgc
      721 gggtgcgcac caccccgtcg gggccggcca ggcagctgag cccgacgaac tcgaactccc
      781 cttccgggcc ggtgcggttg acgtacgcca cgtacatctg gctctcgaag gcccgtacgg
      841 ggacgacgga ttcggcgacg aactggaagg ggtgcatctg cgcggtgggc accagcagca
      901 gatcggtgcc ggccagggcg tgcgcccgga cgttctccgg gaactcgacg tcgtagcaga
      961 tcagcaggcc gatgcggatg ccgtcgaggt cggcctggac gacggtctgc tcgccggggg
     1021 tgaaccactc ctgctcgaag cagccgaaca ggtgggtctt gcggtagttc gcgagccgga
     1081 cgccgtcggc gccgatgagc tgggaggcgt tgaagatccg ctccccgtcg cgctccgggt
     1141 agccgtagag gacggcgagg ccgtggcgta cggcgatctc ggcgatcgcc tcggcgccgg
     1201 ggccgtcggc gggctcggcc aggacgggca cggcgtcgcc gatggcgtat ccggtgagga
     1261 acagctcggg cgcgaccagc agccgggctc cggcaccggc ggcccgggcg gcggcctcgt
     1321 ccagcgtctt caggttctcg gcgacggcgc cgggccgtcc ggagctctgg agcagggcgg
     1381 tgcgcaacga cggcatggct gacctcgggc ggtgcgggcg gggtggggag acgtatcgaa
     1441 ggtacgtggc ccggatcggc ccggacaagg cgcgagcgtt gcgcgccgac cgttgattcg
     1501 ttgcgcacag cgaggcggcg tggcgattcg ttgcgtgctg gaaactccgc aggtcaagga
     1561 tgtgatgtgt acaacggtgc cgctgtgccc gaatgctccc gatagcctga cgtactgctg
     1621 tacccaaggg cagggggcat ggtgacgaac gaggcgcata ggcgtcgaat cgacgaggtg
     1681 gccgggctgg ctgcacgctg gctcgggccg ggtgtgctcc cggggggtcc gcggccggac
     1741 ggttggtggg ccgcattggc agtgcgcacg gcacaggctt cgctcgcatc gcgagaggga
     1801 gcggacgacg tcggcagagc attggcggcc gcggtggacc tcggcctcga cacgggcacg
     1861 gtggccctgc cggttgcgcg ggatgctgtc cagcgggcca tgatggcggt cgttgacact
     1921 gtgccgcttg aggaacccga gtatgcgtgg acgggctggt caccgccgcc cggcgaccgc
     1981 gatccggcgg cccgctggcc gagaccacca gtacctctca tccgttacag gcagggctgg
     2041 gagggttcct ggggggagct gtcccctgcg gaactggggc atcgcctcct ggcgtcccac
     2101 accctcaccg gtgcgtcaga acaactcgac gaagctgtgt ctgttcttca aggcgtggtc
     2161 aggcgactgc caccagacgg aacgcatcag gagtttgcgt acggggatct cgcctggggc
     2221 ctgctcctgc gcttcgtccg ctccggggag cggacggacc tcgatcgcgc gatcgagtgc
     2281 gccatggtcg cgggtgtctt cgatcggccc cccaggagcg gttccgcgct cccgcctccg
     2341 tgggacaccg ttctaggcat ggccctgctg gcccgtcacg agctggcagg cggtcgggaa
     2401 gacctcgaca atgccgtcgc cgcgcttgag cgcgcggcgg ccgggatcgg cgacgatcac
     2461 cccgaccgcg atacggttct gtcaacgttg gccgacgcct tgctgtgccg ccatgcgcag
     2521 cgcgaagact cggctgatct gcttcgggca ggagaactgc gatacgacgt cgagcagccc
     2581 ccctcgttcg ccacagcccg gttcgcggcg tatctcagca gcggcgaccc ggatgccctg
     2641 gacgaggccg tgaccatggg cgtggtggcg gtggagcaga cccgggaccc ggcccaacgc
     2701 gcctggagcc tcaacaacct cgccggctac ctgctggcgc gttaccaagc gcgtcggcac
     2761 cctgacgacg gcgcgggggc cgtggaccgg ctggacagtg cccgggaact gctacggcgg
     2821 ggaaccaccc cgtacgcggt cgtgtccctg aaccttgccc acgcgctcgt gacgggtcct
     2881 gcaccccgcc accgacgagc cctgcggctg gcgagcgagg tactgaaaac gccgcaatcc
     2941 ccgctcacca tccaggcaca ggcgctcgaa ctgatctgtt ctatagctga gttccgcgtc
     3001 ggtcgccctt cactgcccga ggagttcccc gaggatttgg aaatgcggct cggcgccctg
     3061 gaggagcggc tgtacgcaga gtcggcggat gctcgcgcca cgtcactgcg ctgggcccgg
     3121 gccaggcttc gccgggaagc gggacagcgc gaggagagcc gcgagttagc ccaggacgtc
     3181 ctcgccaacc gcgtatggga cgtgctggtt cagcccgacc ctgccgaagc ctaccgatgg
     3241 gcgcatcgag ccctcgacga agcagccgaa atggcgacct ggctctcggc tgacgagcta
     3301 tcggaggaag ccttcgcctc ggtcgaatgc gcacgcggcc tcgcagttca cgctgcggcg
     3361 ggcacggacc cggtcgcagc tcgactcgac gccctcggca gcgacgacct gaggaggcga
     3421 tggctgctcg ccagggagag cacggcgctt ccttcctcgc gcccggagct ccgtcgggaa
     3481 ctcgacgccc cagcagttac cggccaggac cttcggcggc tccgggcgga agtgcagcag
     3541 gccctgacga cgcagggccg agccggatcg gcggtggcgg gccttctcgg ccaggcttcg
     3601 ccgcgggaac tcgccgagaa agtgcgggca gtcggcgccg acgccgtagt gcacctggtc
     3661 tcagggcgcg gcagcagacc cggcctggca ctcatcctgc acgcggccgg ggacgtcagg
     3721 gcgctggcct tgcctgacct gtgcgagacc tcggagaagc tgcgccgttt cgccttggca
     3781 catgacctga gcctgcgctc ccccggagac agggcggata gcgagtgggc caaagcacta
     3841 cgcggtctgt acggctggac ctggcaggcg gtggtggggc cgctcctgga gcaactgtca
     3901 tcccgaccgg aactcactga ccgggcggtt ccacaggtgg tgctggtgcc cacgggaatt
     3961 ctgggtctga tcccctggca caccgcacgc cgcaaggtcg gcggacccgg atggcggtat
     4021 gcgatcgagg acgccagctt cagctatgcc ccgtcggtcg gctcactgaa gggcttcgcc
     4081 gaccgcgccc cagccctgct ggacggcggc ggactggtgg tggccgaccc gtccgatgat
     4141 ctgccgcatg cacggcagga aggaggcgac ctccaccgct ggtactacgc caaaggcccc
     4201 cggctcggcc gctccgcaga tccgagcact ctcccagcca caccgcgggc ggtcctcggc
     4261 gcactcctgc cggacactac gcccgatgca cccgccgtgg cccactttgc ctgccacgcc
     4321 cgtagctgcg ctcccgccgc cgaatcgcat ctggtcctcg ccggtgggca acggctcacg
     4381 gtggacgcac tgctgcggag tgcccgaccc accggtagcc gcgagggccc gttggtcgtg
     4441 ttgtccgggt gtgccacagc agtaccgggt gatcgctacg acgagtccct cagcctcgcg
     4501 accgcattcg cgtcggcggg ggccgcctcc gtcgtgggca ccctctggac ggtgcgggac
     4561 gaggttgcgg cacagctgat gacggacttc caccacttcc tcaacctcga tgggctgccc
     4621 gctgcggaag cccttcgtca gacacagttg cgtgcgctag cgcgggcgcg caggcggacc
     4681 aaaggcggaa gcgctggcgc ccggaccaaa gccgaggacc cactgcactg gggcgccttc
     4741 ctccactacg gaggggggtt ttccgcctca tcccaaccac accccgaccc cgatacggaa
     4801 gctggagagg gaagtggaca gacggcgggg acacgttccc ccatcttcgg caggatgccc
     4861 gggcgcgagc gctccgaagt cgtgtggctc tgtccggaac ccggctgtgc gcaccggacc
     4921 tcgggcgacg cgaaggcgcc gttcgacgag gacacctgtc cttggcatcc tcggcaggcc
     4981 ctgactcggg agtagcccat gggtgaactc gtgaagggca tggtggagcc gctcgccaaa
     5041 cgctggacag cggcgatgag cggtcccctg gtgttgttct ggctggccgg agccctgctc
     5101 gttgctcatg gacagggcgg gcttcccggc gcatgcgatg cgggattgtg gggcatcgcc
     5161 gagcccgcct gccgactcat ggaccagggc gtgtgggggg cggtgctggc aggtgccgcg
     5221 gcgacagcgg tcatggtcct ctgcgcactg gggctgtcgg cggtggcatc cccactgctg
     5281 gagatactgg cggggaggtg gggaacgtgg ccccctgtgg tgaccctcgc cctacggtgt
     5341 accaacggtc acgcggcccg tcgtgagcgg ctcgacacac gggctcgcga cctctccgga
     5401 cccggcgacc tggtcggaga ccgcttggcc gtgtggcgga ctcagaaagc gtggcggcgt
     5461 accgccgatc ggcggaagtg gtcgcactat ccgcgcagac gcgacgagtt gcgccccact
     5521 gcggtgggca acgcgctgca cggagcggcg gccgggatcg agcggaacta cgggctgtcc
     5581 ttgccggtct gctgggggcc gttcgtcgag tgcctggagc ccacagcccg ggaacgccta
     5641 atcgcgtcgg caactcgcgt gctgggccgg acacaggctc tggtctgcgc agctgcggcg
     5701 tcggtgtggg ttgtggccgt gcccggttcg gtggcgcggc tgtgctggct ggcgggctgc
     5761 gcgctgtgtg tctggggcgc gtatcggtcc ctgcgttccg gcatcgaaca gtactgcgag
     5821 catgtgcggg acgtattcgc cgtgcaccgc atccgactct atcgggcggc gggcattgca
     5881 ccgcccccct cgactgccga ggaggtcgaa cgcgggcgcc tgctgacccg tgccctggcg
     5941 atggaactga ccgacgaggt cgtccatgtg tggccggagg ctccgtaaga gaatccgggt
     6001 caggaacgcg aactggcatc ctccggcacc ccggggtccg atctgtccgg cgctcccgcg
     6061 gagtagcgcc gcagcagcgg tgagagcacc agcaccgact tcgtgcgctc gacgtacggc
     6121 tcccccgcga tgcgctccag gacctgttcg aagtggcgca tgtcggcggc gaagacctgc
     6181 accaccgcgt ccgcctcacc ggtcaccgtc gaggccgagg cgatctccgg gtagcgggcg
     6241 aggccctgct tgatcgcgtc cggggaggtg ttgcggctgc agtagatctc gatgaacccc
     6301 tcggtctccc agccgagcgc cgccgggtcg acccgcacgg tgaaaccggt gatcgcgccc
     6361 tcggcgcgca gccggtcgac gcggcgtttc acggcggggg cggagaggcc gacgatggcg
     6421 ccgatgtcgg cgtaggagcg ccgggcgtct tcggcgaggg cgtggacgat gcgttcgtcg
     6481 aggtcgttca ggcgcacgtc gggcggttca ctatctctgc ggtgggtcgg cttgcgggag
     6541 gcggcgcgtg ccgcctcccg cagtagacca cgggccgccg ccccgggcat gccaggtgcg
     6601 gcggggcagc ccgtcagaag gggaactgcg agcggccgtg ctggatggag atccacttct
     6661 gagtggtgaa ggcctcgatc atggagtcgc cgttcaaccg gccgaggccg gagctcttct
     6721 cgccgccgaa ggggacgatc ggctcgtcgt ggacggtgcc gtcgttgatg tggatcatgc
     6781 cggtgtggat gcgctgcccg acccggacgc cgcgctcgat gttgccggtg tggacggcgc
     6841 cgctgaggcc gtacggggtg tcgttggcga tccggacggc ctcgtcctcg ccgtcgaagg
     6901 ggatcagcag ggcgacgggg ccgaagatct cctggtgcag gacgggcgag tcggcggcga
     6961 ggccggtcag cacggagggg ctgaccaggt tgccgtcggc gcggccgtgc aggagggccg
     7021 tcgccccggc cgccacggtc tggtcgacga gcttggagac ggactcggcc tgcgaggagt
     7081 tgatcagcgg gccgatctgg gtggccgggt cggcggggtc gccgacggtg agggacgcga
     7141 ccttggcgac gaacttctcg gtgaactccg cctcgaccga gcggtcgacc aggatgcggt
     7201 tggcggccat gcagacctgg ccctggtgga cgtaccggct gaagaccgcc gcgtcgacgg
     7261 cgtagtcgac atccgcgtcg tcgagcacga tcagggcgct gttgccgccg agttcgagga
     7321 cggcgcgctt gaggttctgg gcgcagacgg tggcgacgtg gcggccgacc ttgtccgagc
     7381 cggtgaagga gatgacctgc ggcacggggt gctccagcag ggtgtcgccg atctccgcga
     7441 tgtcggtgat cacgacgttc agcagtccgg cgggcaggcc ggcgtcctcg aagaccttgg
     7501 cgagcagggt gccgccgcag atcggggtgt tctggtgcgg cttgaggacg acggcgttgc
     7561 cgagggccag cgcgggcgcg acggacttca gggagagcag gaaggggaag ttgaacgggc
     7621 tgatcacgcc gacgacgccg acgggaaccc ggtagacgcg gttctccttg ccctcggtcg
     7681 gcgaggggag gacctgtccg gcggggcgca gcgcgagctg gatcgcctcg cggaggaact
     7741 ccttggccag gtgcagttcg aaggcggcct tcagccgggt gccaccgagc tcggcgacga
     7801 tcgcctcgcc gatctccggc tcgcgctcct cgacgatgcg cagcgccttc tccaggacgg
     7861 cccgcctgct gtacgggttg gtgtccgccc aggcctgctg cgcgcgctcg gcggcccggt
     7921 aggcctggtc gacctcgtcg gcggtggcga ccgggatcga ggcgagcttc tccccgccga
     7981 acgggttgaa gtcgatgatg tcccaggacc ccttccccgg cctccactcg ccgtcgatgt
     8041 actggtgggc caggtcagtg aagaaggaca tgagatccct taccgcagag aggcaggcag
     8101 ctgattgcgg ttcatattac tgagatctca acagagttga agcggccccc cggccacggg
     8161 gacaggcccg aaacgacccc gccccctgcg gcgtggaaca gccggagggg gcggggtcgt
     8221 tggggtgacc ggaggatcaa ctccagctgg cgtgcagggg cttgccctcg gcgtaaccgg
     8281 cggcgctctg gacgccgacg accgccttct cggcgaactc cgcgagcgag ccggcaccgg
     8341 cgtaggtgca ggacgagcgg acgccggcga tgatcgagtc gatgaggtcc tcgacgcccg
     8401 ggcgggccgg gtcgaggaac atccgcgagg tggagatgcc ctcctcgaag agcgccttgc
     8461 gggcgcggtc gtaggccgac tcgtccgagg tccggttctt cacggcgcgg gccgaggcca
     8521 tcccgaagga ctccttgtag aagcggccgt cggcggactg ctggaggtcg ccgggcgact
     8581 cgtaggtgcc cgcgaaccag gagccgatca tcacgttgga cgcgcccgcg gcgagcgcca
     8641 tggcgacgtc gcgcgggtgc cggacgccgc cgtccgccca gacgtgcttg ccgtgcttcc
     8701 tcgcctcggc ggcgcactcc aggacggcgg agaactgcgg gcggccgacg ccggtcatca
     8761 tccgggtggt gcacatggcg ccggggccga cacctacctt gatgatgtcc gcgcccgcct
     8821 cgatcaggtc gcgcacgccc tcggcggcga cgatgttgcc cgcgacgatc gggacctgcg
     8881 ggtcgagggc ccgtacggcc ttcaccgcgc tgatcatgga ttcctggtgg ccgtgggcgg
     8941 tgtccacgac gaggacgtcg gcgcccgcgt ccaggagctg cttggccttg ccggccacgt
     9001 cgccgttgat gccgacggcg gccgcgatgc gcagcttgcc cccggcgtcg gtggcggggg
     9061 tgtagagcgt ggcgcgcagg gcggccttgc gggtgaggat gccgacgagg cggccgtccg
     9121 cgtcgaccgc aggggcgagc ttgcggttgg cgccgtcgag cttgttgaac gcgtcgcgcg
     9181 ggtcgatgtc cgcgtccagc agcacgaggt ccttggtcat gacctcggag agctgggtga
     9241 agcggtcgac gccgctgagg tcgtgctcgg tgacgacacc gacgggacgg cggtcggcgt
     9301 cgacgacgac acccgcgccg tgcgcccgct tgggcagcag cgagagcgcg tcggcgacgg
     9361 tctggccggg ggccagctcg atcggggtgt cgaggacgag gtggcgcgtc ttgacccagg
     9421 agatgacgtc ggtgacgacc tcgatcggga tgtcctgggg gatgacgacg aggccgccgc
     9481 ggcgggcgac ggtttcggcc atccggcggc ccgcgatggc ggtcatgttg gcgaccacga
     9541 gcggaatggt ggtgccggtt ccgtcgggcg acgagaggtc cacaccctgg cgggagccga
     9601 ccgcggagcg gcccgggacc atgaagacgt cgtcgtacgt gaggtcgtac gggaccgcgg
     9661 gggactctgt gtagcgaccg gtgcccggct caagaaaacg cataactctc attttttcat
     9721 acgaaaccgc gcaggtcgtt tccccgaaga cacagcaaaa gacccccgct ttcgtctgat
     9781 cctccgaaga ggtgaccggg ggtcccgggc aagtgaacct gccttaccca cggactctac
     9841 ccgaacagga ttcgaagcat tcgtgatcac catccctgga ccgggtgaca aggggtcagg
     9901 tagcttcaaa gccgcaggtc tcgggggtgt cggaagcgtc gatccggctc gtcggcaacc
     9961 ctgggcacac cgtttgaccg gagaggatcc cgatccgcct gtggacagcg aactgccgga
    10021 catctactgc ccgttcccgc agcggaccaa tccgcacgtg gcgcacaccc gggagcatct
    10081 ggacgcctgg accagacgga cggggctggt ccatcgcgag tccgcgagga accgattcga
    10141 acaagccgat ttcggggcgt tcgtcggcat ggtctacccg acggccgacg aggaacacct
    10201 cgatctggtg gccgactggt tcgtctggct cttcctggtc gacgaccagc tcgacgacgg
    10261 ccacctcggc cgttcacccg accgggtgag aagcgtggtc gaacggatgc gcgcggtcgt
    10321 cgacggctcc gcccccgggc cactgccggg cgaggacgtc cccgcggccg tgaccgccct
    10381 ggccgacctg tggaaacgta cgacgccgaa cgcggccccg cactggcgga cccggttcgc
    10441 ctggcatctg gtgacctacc tcacgaccgc cacgacctgg gaggcgggca accgcgccga
    10501 ggacgtggtg ccctcggagg acacgtacat cgccaagcgg cggcacaccg gggccatcca
    10561 cgtctgcatg gacctcatag agatcgtggc gggcatcgag gccccggagt cgctccacaa
    10621 cgacccccgc ttcatcaccg ccctggaagc cgcgtgcaac cacgtctgct gggccaacga
    10681 cgtgtactcc ttcgagaagg agcaggtgct cggcgagatc cacaacctcg tccacctggt
    10741 ccgccaccac cggggcctcg gggagcagca ggcgctggac cacgtcgcgg agcggctcgc
    10801 gatggagacc gagcggttcc tgaccgccga ggacgagctg ctggagctgt atccggagct
    10861 gtcggggctg ctggtgccct acctggacgg gatgcggagc tggatgcgcg gcaatctgga
    10921 ctggtcgcgc cagacgcccc gctacaaccc cgcggacgtg gggcagtacg aggagcccga
    10981 ggagtatctg gaggagacgg tgctgggcgt cccgcccgcg cgcaccgagg ccgcagcccc
    11041 cgccccgtgc gcggccaagg cacccccggc cggctgaggg acagagtcac gacatgccga
    11101 gggccgtgca ccccgcaagg tgcacggccc tcggcgcgtc ctcggtgtca ctccccgtcg
    11161 gggtcggccc gctccagcgc cgggcgcacc cccgcggcgg attcggtgag cagatagtcg
    11221 gccgctgcgg tgtccgtgac caggctggtg accaggccgg agcggagcac cgcgccgatc
    11281 gccgccgcct tgcgctggcc gcccgcgatc gcgaccacct cggggatccg gcgcagccgg
    11341 tccgcctcca cggtgatgca gcgctccccc aggtcgcggc cgacccggcg gccttccgcg
    11401 tcgaagaggt gtgcggacat ctcggcggcg acgccgagcg aggcgtagtg ggcgcgctcc
    11461 tcgtccgaga gcatgtcgtg gaccgtggag atgcccggtt cccaggagcc gatggagacg
    11521 gcggcgacgg tcaccttgtc gaagtactcg aaggctcggg cgatgcccgt ctgctcgcgc
    11581 agcgcggcgg ccgtcgcggg gtcgggcagc agcatcgggg cgtagatggg gtgcgcctcg
    11641 ccgccggaga cctgggcggc ccggcggacc gcctcgaccg agccgcgctc ggcggtgccc
    11701 gcgtcgtaca ccccggtcag ctggacgacc gtgcagggcg gcagccggtc gagtgcggcc
    11761 gccatgtgga tggtggagcg gccccaggcc aggccgagca catcgccctc ggccaccagc
    11821 tcgccgagga ggtcggccgc gacctcgccc agattctccg ggtcgggggc gtcgtcctgt
    11881 tcctcggccg gggattcgac gaccaccgcg tgccgcagcc cgtagcgggc gcgcagggcg
    11941 tcggagcgtt cggcgtccag ctcggccggg acccggatct cgatgcgtac gagatcgcgt
    12001 tcgagggcgg tctccaggac ccgggccacc ttgaagcggc tcacgccgaa ctcctcggcg
    12061 atctggatct tggacttgcc ctccagatag aaccggcggg ccatggccgc cgcctgcacc
    12121 agctccgcgg gtcccatccg catggctgac cgacccgccg agatgccaga caccgcgatc
    12181 tcctcactgc tgttcacacg cccgatacgc cgttcatcct gtcagatccg gcgatccttg
    12241 atcggccctg tcggaccgcg ttcatctgcc cttggttcag tggtcgcatg cccagggggc
    12301 cgcggccgtc gccacgtccg ccaggccccg caggtcccgc acggccgccg ccgggtccgc
    12361 cgccccgtag accgcggatc cggccacgaa gacatcggct ccggcctcgg cgcagcgctc
    12421 gatggtggcg gccgagaccc cgccgtccac ctggagccac agttcgagac cgtgcttgct
    12481 gatcagttcc cgggtacgcc ggatcttcgg cagcatgatg tccaggaagg cctgcccgcc
    12541 gaagcccggc tcgaccgtca tgatcagcag catgtccagc tcggggagca ggtcctcgta
    12601 cggctcgatg ggcgtcgcgg gcttgagcgc catcgaggcg cgcgccccct tcgcccggat
    12661 ctcccgcgcg aggcgcaccg gcgccgcggc ggcctcggcg tggaaggtga cggacccggc
    12721 gccggcctcc acgtaactcg gggcccagcg gtccgcgtcc tcgatcatga ggtggcagtc
    12781 cagcggggtg tccgtcgcct tgctgagcgc ctcgacgatc ggcacgccga gggtcagatt
    12841 gggcacgaag tggttgtcca tgacatcgac gtggagccag tccgcgcctt cgacggcctt
    12901 cgcctcctcg gcgagacgcg cgaaatcggc ggacaggatg ctggggttga tctgcgccat
    12961 gccccaagcc tgccacgtct gcggccggtt ccccgcctcg atcccctccg aagcctcaca
    13021 cggccctcac agtccgcaca ttctgggcat tttgccagcg ctttactttt cttttgccgt
    13081 acgggcgggc gcgctgacgc ggcgatattc agccggtccg gcgcagcaga gccagataca
    13141 tcgcgtccgt gccgtggaga tgcggccaga gctggacgtc gggcccctcg cccagggcag
    13201 gcaccccggg cagcagcggg cgggcgtcga tccactccgc ctcgacgggc tccccgccgc
    13261 ggcccttgag cacgtcctcg acgaccaccc gggtctccgc gagatgcggc gaacaggtgg
    13321 cgtagccgac cacgccgccg acccgtacgg ccttcaacgc ctcgcgcagc aggccgcgct
    13381 ggagcggggc gaaggcctcc aggtcctcgg cgcgccgccg ccagcgggac tccgggcggc
    13441 ggcgcagcgc gccgagtccc gagcagggca cgtccatcag gatgcggtcg aaggtgccgg
    13501 gcagccacgg cgggcgggtg ccgtcggcgg tgatcacctg gtacgggccg gggttgccgg
    13561 cgagcgcccg ctcgaccagc cgggcgcggt ggggctgctt ctcggcggcg agcagcgtcg
    13621 cgccgcgttc ggcggccagc gccgcgagga gggcggcctt gccacccggg cccgcgcagc
    13681 cgtccagcca gcgcgagtca cggccctcga cggggacggc ggccagggcg gcggcgacga
    13741 gctggctgcc ctcgtcctgg acgcccgccc ggctctcgcg gacggcctcc agcgcaccgg
    13801 gctcgccgcc ctcggccatc cgcacggcgt acggggacca gcggccgggc agggagttgt
    13861 cctcgcccag ggccttgacc agctcctcgg tggtggaacg gccggggcgg gcgaccaggg
    13921 tcacctcggg ccgctcgttg tcggcctcca gcaggtcctc gatgcccgcc cggccgccgc
    13981 ccagcgcgtc ccagagggcg gagacgatcc agcgggggtg ggagtggacg acggcgaggt
    14041 ggtcctcggc gtcctcgtcg tacggcgggg cgaccttctc cacccagccg tcgaggtcgt
    14101 gcgcggtgac cttgcgcagc accgcgttga cgaacttcgc acgcccctcc cccagcacca
    14161 cccgggccag ctcgacactg gcggagacgg ccgcgtgggt ggggatacgg gtgccgagca
    14221 gctggtggac gcccatgttc aggacgtcca ggaccggcgg gtcgacctcg cgcagcggcc
    14281 ggtcgatgca ggccgccacg atcgcgtcgt acgtgccctg gcggcgcagc gtcccgtaga
    14341 ccagctcggt cgccagcgcc gcgtcccggc cgtcgaagtc gcccttggcg cgggccttct
    14401 tcagcagcgg gggcagcacg aggttggcgt acgcgtcccg ttcgtcgacg gcccgcagcg
    14461 cctcgaaggc gaggaagcgg accgggtcct tcttgggccg gcggtgaggc ttggcgggac
    14521 ggcgacgcgg ctggtcgttc acgtgaaagg tgctccgctg aaggtgaggg ggcgaaccct
    14581 cccagcgtac gacgccgtcc cgggcctccc gaacgagagg ttccccggcc ccgggggcta
    14641 cgagcccagc agctcgccgt gggcgatccg gacgccgcgc gcccagtcgg cggcccgcat
    14701 cggcttcttg ccctgcggct ggacccagag cagctcgacg gcgtgggatc cggtgccgac
    14761 gtacacgttg ttcttggcgg ccgacagctc cccgggggcc aggtccgtgc ggtccaggac
    14821 gggggtcgcc tggatcagct tgagccgctc gccgcggaac acggtccagg cgccgggggc
    14881 cggggtgcag ccgcggatca cccggtcgac gcgcagggcg ggcgcggacc actggacctg
    14941 ggcgtcctcg acggtgatct tcggggccag ggtgacgccc tcgtgcggct ggggcacggc
    15001 gtgcagggtg tcgtcctcga tgccgtccat ggtggcggcg agcagcccgg cgccggcgaa
    15061 ggcgagccgg gtgagcaggt cgccgctggt gtcggtgggg cggatctcct ccgtgaggac
    15121 gccgtagacc gggccggagt cgagcccctc ctcgatcagg aaggtcgacg cgccggtcac
    15181 ctcgtccccg gccatcaggg aatgctgcac gggggccgcg ccgcgccagg cgggcagcag
    15241 cgagaagtgc aggttgaccc agccccgggc gggcacgtcg agggcgacct tgggcagcag
    15301 ggccccgtag gcgacgaccg ggcagcagtc cggggcgatc tcgcgcagcc gggcgagaaa
    15361 ctcctcgtcc cggggcttga ctggcttgag cacctcgatc ccggcctcct ccgcccgctc
    15421 ggccaccggg ctcgcgacga gccggcgccc ccgcccggcg ggggcgtcgg gacgggtcac
    15481 gacggcggcc acctcatggc ggtcggaggc gatcagggcg tccagggcgg ggacggcgac
    15541 ttcgggggtg ccggcgaaga cgagcttcat gggtggctga ctgcctctcg ggccaagacg
    15601 tacggtgacg agcagcacac cagtctaggg tctcgggtcg aaccgggccc ggccgcaccc
    15661 gtgcgcgagg gcggcgcccc tctgtgcgca ggggcggcga ccccctctgt acagggacgg
    15721 caactccctt gcgcggggcg gcgaccaggg ggcgtacgcg cgccgcgcac gccccgtgca
    15781 tatgcacata cgccccgata gcgtgaccac atacccggct cgggcgttgg tcaaaggaga
    15841 ttgaccgaag cgggccgccc cgatcgcggc ccgatccctt tcaacgccgg ttcgagaggc
    15901 ttcttcatgg ccgaccacgc aacgcacgac gcccaagcgc gggccagtct gcatcttctg
    15961 gtgcgggaca tcgagcgggt caggcggcag gtggacgcgc tgcgcaccct caccgcccag
    16021 ctgggcaacg tctaccgtcc gcgccgctcc ggcccttccg cgggcttcgt cgtctacggc
    16081 agggccccgg cccccaccgt ccgcctcgcg caggaactgc gggacagcgt cgagaccctg
    16141 gtgacggccg cggtggactt cgaccgctcg ctgggcttct cctgggacgc ggtgggctcc
    16201 gccctcggcg tcaccaagca ggccgtccac cgccgttacg gaacccgccg cgccaccccg
    16261 cagcccgccg ccgagacggg cggcgagaac acggccgtgc cgcgcccggt ctccgtcggc
    16321 agcggcctca ccggatcctc cgccaagggg tccggctccc cggtgcccac ggtcccggcg
    16381 gcccgctcga tgccgccgca gccgtcggcg gccccgcagc cggcccgcga ggagctgcgc
    16441 cccggtgcgt tcccgggccc gcgcaacggc tgaccgtaca ccgccccctg ccccaccgtg
    16501 ccggtcgcac ggcggggcag tcccctgtcc gggcccgggt cacggaggaa gctgcgtcgc
    16561 ggggctcagc cgatgtccgg cgggtcgatc ctgatgcgta ccgggtcgtt cgcgcccttg
    16621 gccgtgcggg ccgcgagcgc cgtcttcaag gcgcgggcga gcgcggcccc gcgccccggg
    16681 accacccgga ccagggcccg ctcccaggtc tcgcccggtg gcgcgtctcc cggtctgcgg
    16741 gcccttccgg gcgcggccga gggggccggc accggtccca ggatctcggc ctccggcggc
    16801 agcccggcag tctgcaggaa cgcggccaga gcctcgggcg ggccggtcac cgaggccatc
    16861 cgggagaccg gcgggaagcc cagctcggcg cgatccgcca gctcccgccg ggcgaacccc
    16921 gccggatccc agcggaccag cgcctgcacc gcacgctccg tcggctcggc cacgaccacc
    16981 accgtgccgc cctcctcctg cccccgcacc agcgccgacg ccgccagcca ccggcgcagc
    17041 gcctcctccc ccgcgcgcag atcgggccgg ccgagcatgg cccagccgtc caggagcagg
    17101 gccgccgtgt acccgccctc ggcgacgggt tccgcgccgg gcgtggaaac gaccagggcc
    17161 ggggcgtcgg gcaccgcgtc gaggatgtgg tcgcgcccgg aggtgcggac gggcacggcg
    17221 gggaaggccc ggcccagctc ctccgcggtg cggcgggcgc cgacgatccg ggcgcgcagc
    17281 cgggtggagc cgcactccgc gcagctccag gcccgctcgg cctgcccgca ccaggcgcag
    17341 ttcagatcct gctggtccgg cgcttccagg gggcccgcgc agtgccggca gcgggcgggg
    17401 gtgcggcagc gttcgcaggc gaggcggggg gcgtaacccc gccggggcac ctggatcagg
    17461 accggtccgg tgcgcaggcc gtcgcgcacg gccccccagg cgaggctggg cagccgggcg
    17521 gagcgggcgg ccccgtcccg ggccagctcg ccgtccccga ccgtacggat gaggggcgcg
    17581 gcccggcgca gccgttcgcg gtccgccagg aggggcagcg cccagccgct ctccacgagc
    17641 tgggcggcct cgaccgtgca gctggtgccg ccgagcagga agccgcagcg gccctgggcc
    17701 gcccgcagct ccaggacctc gcggacatgg gggaaggggg cgttgtcgtc gctgtggctg
    17761 gagtcgccgt cgtcccagac gacgacgagc ccgaggtcgc ggacgggggc gaacatggcg
    17821 gcccgggtgc ccacgaccgc ccgcaccgag ccccggcgta ccgcgagcca ctggcggtag
    17881 cgcttctcgg ggccggattc ggcggtcagc agggcgtgcc gacccgcgcc gagcgtctcg
    17941 gtcagagccg cgtcgacccg tgcggcggcc cgcccgtccg ggacgacgac gagggcgccg
    18001 cgcccggagg agagcgtcgc cgcgacggct ccggcgatct ccgcgggcca gtgcggtccg
    18061 ggcagggcgg tccacacggc gcgcggggcg ccgccctcgg ccagggctcg caggaaggcc
    18121 gggccctggc cgtaccgctc ccaggtgccc ggatccgggg gcgggggcgg gggcagcggt
    18181 tccggggagg gcttggcctc ggcgcggccg ttgcgcggcg ggacggcgag ctggaggacg
    18241 tcggcgaggc tgcccgcgta ccggtcggcg acggcgcggc agagggcgag cagctcgggg
    18301 ccgaggaccg gctccgggga gaccacggag gcgagggcgg ccagcgcgcc ctggtagtcg
    18361 gagtcggcgc ggcgctcgac gatgaagccg tcgatcaggc cgccgccctc gcgccgccct
    18421 ccctggacgt tgcgcccgcc ggccccgaag cggacccgca cccggacgcc cggctgtgcg
    18481 tcggcgtcca gctcctgggg caccgcgtag tcgaaatact ggtcgaggtg gaggacgccc
    18541 ttgttgacca ggacgcgggc gacgggcagg tcgtcggcga ggggcgcgcc gcgccaggtc
    18601 cgcggcttgg cgcgcggcac cttcgcccgg cgcacggtct cccggatcag cgcaagctgc
    18661 tccggcggcc cggcacccgc ttcggcggac tgctcgttct cgctgctcac agctgcattc
    18721 ctaccagagg gcactgacag tccggagagc actgacagtc cggagagcac ggaaatcgtg
    18781 ggggcacggc agcggggccc ggccaccgtg ttcggtgtcc gggccccgcc gtcactcagt
    18841 accgatgccg gatcaggtcc ttacagaccc gcggccgcgc gcagcgcgtc cacgcggtcc
    18901 gtgcgctccc aggtgaagtc cggcagctcc cggccgaagt ggccgtacgc ggcggtctgg
    18961 gcgtagatcg ggcggagcag gtcgaggtcc cggatgatcg cggccgggcg gaggtcgaag
    19021 acctcggcga tcgcgttctc gatcttctcc gtgtcgatgg cggcggtgcc gaaggtctcg
    19081 acgaagagac cgacgggctc ggccttgccg atcgcgtagg cgacctggac ctcgcagcgg
    19141 gcggcgagac cggcggccac gacgttcttg gcgacccagc gcatcgcgta cgccgcggag
    19201 cggtcgacct tggacgggtc cttgcccgag aaggcgccgc caccgtggcg ggccatgccg
    19261 ccgtaggtgt cgatgatgat cttgcggccg gtgaggcccg cgtcgcccat cgggccgccg
    19321 atctcgaagc ggccggtcgg gttcaccagg aggcggtagc cctcggtgtc gagcttgatg
    19381 ccgtcctcga cgagctgcgc gagcacgtgc tcgacgacga actcgcggat gtcgggcgcg
    19441 agcagcgagt ccaggtcgat gtccgaggcg tgctgcgagg agacgacgac cgtgtcgaga
    19501 cggaccgcct tgtcaccgtc gtactcgatg gtgacctggg tcttgccgtc ggggcgcagg
    19561 taggggatgg tcccgttctt gcgtacctcg gagagccgcc gggagaggcg gtgcgcgatg
    19621 tggatcggga gcggcatgag ctccggggtc tcgtcgcagg cgtacccgaa catcaggccc
    19681 tggtcgcccg cgccctgctt gtcgagctcg tcctcgtcac cctcgacccg cttctcgtac
    19741 gcggtgtcga cgccctgggc gatgtccggc gactgggcgc cgatcgacac cgagacgcca
    19801 caggaagcgc cgtcgaagcc ctttttggag gagtcgtaac cgatctccag aaccttgttg
    19861 cgcacgaggt tggggatgtc ggcgtaggcc ttggtggtga cctcgcccgc gacatgcacc
    19921 agaccggtgg tgatcaaggt ctcgacggcg acacgcgagg aggggtcctc acgcaggagc
    19981 gcgtcgagaa tcgtgtcgct gatctggtca gcgatcttgt cggggtgacc ctcggtgacg
    20041 gattccgagg tgaaaaggcg gcgggacaca tcgctccctg gggttgcagc ggctgctggc
    20101 tgatcatggg tggcacgtcc gagagctgcg ctcggcgcgt accgtcggcc agtttatcgg
    20161 tcacttccgg cgaccgggcc aggtgtctcg ccctttggga ggttcgtgac gtgcgccaca
    20221 cagatcacca gtaggacaat tcaccctcct cagccgccgt tttcggcgtt atggggcgat
    20281 ttcactcgcc cgaagggctg atcaggaatt cggctggaac ctggcggaaa ccagatccca
    20341 gatcgtgtcg gcgagggctt ccttggggcc gtacggcacc ggcgtctcct ggccgtcggc
    20401 ggcgaggacg accgcttcgt tctcctccga gccgaaggtc ttgcgctccc ccacctcgtt
    20461 gaccacgagg aggtcgcagc ccttgcggcg gagcttggca cgtccgttgg ccagcacgtc
    20521 gtcggtctcg gcggcgaatc cgacgacgat ctggccggcc cgggcccgct ccccggcgac
    20581 ctcggcgagg atgtcggggt tgcggaccag ggtgagcgcg ggcgcctcct cgccgtcctt
    20641 cttcttgatc ttgccggtgg cgtactcgga cgggcggaag tcggccaccg cggccgccat
    20701 caccacgacg tccgcgtcgg cggcggcctt caccacggcc tcgcggagct ggacggccgt
    20761 gccgacccgc aggacgtcgg ccccggccgg gtcgggcagc ccggtgttgg cctcgatcag
    20821 ggtgacccga gccccccggg ccacggcggt gcgcgccagc gcgtagccct gcttgccgga
    20881 ggagcggttg cccaggaagc gcaccggatc gagcggctcg cgggtgcctc cggcgctgat
    20941 caccacatgg cggcccgcga ggtcgggctc gggaaccccg cgcgccagga cccggcggca
    21001 gacctcgaag atctcgccgg ggtcgggcag ccggcccttg ccggtgtcga cgccggtgag
    21061 ccgcccgacg gcgggct
//
