LOCUS       NZ_KZ819178            10945 bp    DNA     linear   CON 08-MAY-2024
DEFINITION  Streptomyces sp. CS131 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ819178
VERSION     NZ_KZ819178.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS131
  ORGANISM  Streptomyces sp. CS131
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7968990)
  AUTHORS   Malmierca,M., Ceniceros,A., Mendez,C., Salas,J.A. and Olano,C.
  TITLE     Genome analysis of twelve Streptomyces spp. associated with Peruvian
            leafcutter ants
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7968990)
  AUTHORS   Malmierca,M., Ceniceros,A., Mendez,C., Salas,J.A. and Olano,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-APR-2018) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 88.88x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003116755.1-RS_2024_05_06
            Annotation Date                   :: 05/06/2024 09:38:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,994
            CDSs (total)                      :: 6,912
            Genes (coding)                    :: 6,769
            CDSs (with protein)               :: 6,769
            Genes (RNA)                       :: 82
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 143
            CDSs (without protein)            :: 143
            Pseudo Genes (ambiguous residues) :: 0 of 143
            Pseudo Genes (frameshifted)       :: 41 of 143
            Pseudo Genes (incomplete)         :: 122 of 143
            Pseudo Genes (internal stop)      :: 12 of 143
            Pseudo Genes (multiple problems)  :: 31 of 143
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:40:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 72267
            Orig. end                         :: 83212
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ819178.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Professor JA Salas
            laboratory.
FEATURES             Location/Qualifiers
     region          1..10945
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="2"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10945
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10945
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5945](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5945)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    197..212
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.99"
                     /tool="antismash"
     misc_feature    complement(1019..1028)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(1141..2181)
                     /locus_tag="DBP20_RS00325"
                     /old_locus_tag="DBP20_00325"
     CDS             complement(1141..2181)
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (19-269). E-value: 8.3e-13.
                     Score: 40.1. Matches aSDomain:
                     nrpspksdomains_DBP20_RS00325_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761872.1"
                     /locus_tag="DBP20_RS00325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00325"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_032778053.1"
                     /sec_met_domain="ADH_N (E-value: 6.5e-28, bitscore: 95.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-22, bitscore:
                     78.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVAAYAAPRAKAPLERTTIERRPVGEFDILIDIKFAGICHSDI
                     HQARDGWGEGIFPMVPGHEIAGIVAETGSGVTRFKVGDRVGVGCMVDSCGQCDACLMGR
                     EQHCAEGNTQTYNALDRSGEPTYGGYSTHLVVTEKFAVTIPEGIALDEAAPLLCAGITT
                     YSPLKRWGAGPGKKVAVVGLGGLGHMAVKIAHALGAEVTVLSQSLRKKDDGLKLGADHY
                     YATSDPKTFEELAGTFDVILSTVSAPLDFGAYLGLLRTEGTLVNVGAPEEPISLNLFSL
                     ILGNRSIAGSAIGGIKETQEMLDFCAVHGLGAEIEVIDANQVNEAYERVLASDVRYRFV
                     IDTATI"
     aSDomain        complement(1375..2124)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DBP20_RS00325_PKS_ER.1"
                     /evalue="8.30E-13"
                     /label="DBP20_RS00325_PKS_ER.1"
                     /locus_tag="DBP20_RS00325"
                     /protein_end="269"
                     /protein_start="19"
                     /score="40.1"
                     /tool="antismash"
                     /translation="TIERRPVGEFDILIDIKFAGICHSDIHQARDGWGEGIFPMVPGHE
                     IAGIVAETGSGVTRFKVGDRVGVGCMVDSCGQCDACLMGREQHCAEGNTQTYNALDRSG
                     EPTYGGYSTHLVVTEKFAVTIPEGIALDEAAPLLCAGITTYSPLKRWGAGPGKKVAVVG
                     LGGLGHMAVKIAHALGAEVTVLSQSLRKKDDGLKLGADHYYATSDPKTFEELAGTFDVI
                     LSTVSAPLDFGAYLGLLRTEGTLVNVGA"
     gene            2344..3273
                     /locus_tag="DBP20_RS00330"
                     /old_locus_tag="DBP20_00330"
     CDS             2344..3273
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007459219.1"
                     /locus_tag="DBP20_RS00330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00330"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_032778054.1"
                     /transl_table=11
                     /translation="MDDQPEAAAPEPLDRRAELSEFLRTRRARLQPQDVGLPEFGRARR
                     VPGLRREELAQLAGVSVAYYTRLEQGNGRNVSAEVLDAIARALRLTDAEHAHLNHLARP
                     ARHKKKRRPAKVQRVRTGLLYLLDSMEGIPAYVAGARSDILAWNPMAAAVFGDWAALPA
                     AERNWARLVFLSPAYRDLFLNWDSKASDMVSYLRLYAGCHPDDPQLSALVGELSLKSEE
                     FRRLWATHNVKEKGHGIKLIRHPLVGDLTLSYETLNLPDDEDQQLVTYHAEPGSESAQA
                     LRLLASWGADAGRADVISGAGRSPDDER"
     gene            complement(3313..4014)
                     /locus_tag="DBP20_RS00335"
                     /old_locus_tag="DBP20_00335"
     CDS             complement(3313..4014)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515159.1"
                     /locus_tag="DBP20_RS00335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00335"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_109177331.1"
                     /transl_table=11
                     /translation="MTKQERATRTRQALIRSAAVVFEQHGYAQARLTLISSGAGVSTGA
                     LHFHFENKAAVAEAVVAEASRGLRDMSAAIRRRTDTALQALVDTSHALVELLRGDPVSR
                     AGFRLSCDGERAAAPDLRLEWHHRVRELLEEAAAAGTLADDIAREDAAAATVAVTAGFE
                     VLGRHDTEWLSPYRLTGFWQLLLPRLAAAKTLPLLDPAGTGAVASTLAPALAASAVGEA
                     EETAALTAEPT"
     gene            complement(4139..4987)
                     /locus_tag="DBP20_RS00340"
                     /old_locus_tag="DBP20_00340"
     CDS             complement(4139..4987)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060637.1"
                     /locus_tag="DBP20_RS00340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00340"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_093444594.1"
                     /transl_table=11
                     /translation="MILVTGATGAVGREVAALLAAAGPVRILARRPDRVTVRGDGVEVV
                     EGAYGDRPALDRALRGVNSLFLVTNSPTEPDDERVAGAAHAAGVRHLVKLSMMAVEEPG
                     ADDFITRRQRENEEAIRESGIAWTFVRPRTFMSNTLSWAPGIRSAGVVRALYGDAPVAC
                     IDPRDVAAVAVAVLTGTGHEGRAYAVSGPEAITAREQTAQLSRVLGRPLRFEELGLDAA
                     RAALLAKYPRPVAEAFLESAERQRAGAKAAIVPTVQELTGRGARTYRTWSADHADAFAA
                     G"
     gene            complement(5001..5945)
                     /locus_tag="DBP20_RS00345"
                     /old_locus_tag="DBP20_00345"
     CDS             complement(5001..5945)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971211.1"
                     /locus_tag="DBP20_RS00345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00345"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_093444595.1"
                     /sec_met_domain="AfsA (E-value: 1.2e-25, bitscore: 88.1,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEAAALIDSVPAMDSEADMVHPVGIDMVHRTRPEDAFPRNWVRL
                     AHDRFSVAAVLPHDHPFFAPVGGDRHDPLLVAEAMRQAAMLAFHAGYGVPLGYHFLMAD
                     LDYVCHQDHLGVGGAPTEIDVEVFCSDLKWRSGLPVQGRVGWAVHRGGELAATGMGATR
                     FTNPKVYRRMRGDAPAEGISIPEAAPVDAARAGRSRTEDVVLSDTGREGVWELRVDTRH
                     PTLFQRPNDHVPGMLLLEAARQAACLAAGPGGIVPAEASTRFHRYAEFGSPCWISAVIQ
                     PEEAEDTVTVRVTGQQDGEPVFSTLLSGPRADG"
     gene            6106..6744
                     /locus_tag="DBP20_RS00350"
                     /old_locus_tag="DBP20_00350"
     CDS             6106..6744
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060641.1"
                     /locus_tag="DBP20_RS00350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00350"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_088576141.1"
                     /transl_table=11
                     /translation="MAKQDRAIRTRQAILMAAAQAFEKYGYQAATITEILKSADVTKGA
                     LYFHFPSKEDLALGVLHAQEPPQTVPEQSLKLQELIDLGMLFSHRLQTSLLARAGVRLS
                     MDQQAQGLDRSGPFLRWQEATHHLLAQAKHNGELLPHVNPTETADLYVAAFTGTQAVSQ
                     TLTNYQDLQRRHITLQQHILPSIAAPSILTALDLTPARAERLGRLAPED"
     gene            complement(6769..7734)
                     /locus_tag="DBP20_RS00355"
                     /old_locus_tag="DBP20_00355"
     CDS             complement(6769..7734)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060643.1"
                     /locus_tag="DBP20_RS00355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00355"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_109177332.1"
                     /transl_table=11
                     /translation="MGNVHRVAVLALDGVYPFELGIPNRVLGAADGRYSVVTCTVDGRP
                     VRTNADFSITVEHGPEVLATADTLVIPPFDTSLLTREAPADALAALAAVRPGTRIVSIC
                     TGAFLLASAGLLDGRRATTHWALAELFRSWYPQVRLDPDVLFIDDGGVLTSAGAASGVD
                     VCLHLVRADHGSEIANRVARLCVVPPWRDGGQAQYIEQPVPAPAANDTATTRDWALRNL
                     QEPLSLASLAEHARMSRRTFVRRFNEEVGMSPGRWIVQQRVDRARHLLESTDLAVDEIA
                     GRVGFATGASLRQHLHAAIGVTPLAYRRTFRGAVLAAGRP"
     gene            7804..8754
                     /locus_tag="DBP20_RS00360"
                     /old_locus_tag="DBP20_00360"
     CDS             7804..8754
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (26-313). E-value: 4.9e-54.
                     Score: 175.5. Matches aSDomain:
                     nrpspksdomains_DBP20_RS00360_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060646.1"
                     /locus_tag="DBP20_RS00360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00360"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_239475216.1"
                     /sec_met_domain="ADH_N (E-value: 7.6e-08, bitscore: 30.9,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.1e-16, bitscore:
                     59.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKNESMRAISQSVYGGPEVLEEVRLPRPVAGPSQITVAVRAAGV
                     NPTDWKHRGQGMFLDRLPLVLGWDVSGVVESVGFGVTLFKPGDEVFGMLPYPYGVGSHA
                     EFAVGPARAFAHKPEGVDHVRAAAVPLAALTARQALVDTADVRPGQRVLIHAAAGGVGH
                     LAVQIAKSLGAYVIGTASAAKHDFVRGLGADEVIDYRTVDFGDAVSDVDVVLDPLSGET
                     RARSLDVLRPGGTLVSLLPGGDPAEAAKAAAREIRVENLLVEADHAGMTAIADLIRAGE
                     LRAHVEASFPLAEAAKAHALGETGRTTGKLVLVVS"
     aSDomain        7882..8742
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DBP20_RS00360_PKS_ER.1"
                     /evalue="4.90E-54"
                     /label="DBP20_RS00360_PKS_ER.1"
                     /locus_tag="DBP20_RS00360"
                     /protein_end="313"
                     /protein_start="26"
                     /score="175.5"
                     /tool="antismash"
                     /translation="PRPVAGPSQITVAVRAAGVNPTDWKHRGQGMFLDRLPLVLGWDVS
                     GVVESVGFGVTLFKPGDEVFGMLPYPYGVGSHAEFAVGPARAFAHKPEGVDHVRAAAVP
                     LAALTARQALVDTADVRPGQRVLIHAAAGGVGHLAVQIAKSLGAYVIGTASAAKHDFVR
                     GLGADEVIDYRTVDFGDAVSDVDVVLDPLSGETRARSLDVLRPGGTLVSLLPGGDPAEA
                     AKAAAREIRVENLLVEADHAGMTAIADLIRAGELRAHVEASFPLAEAAKAHALGETGRT
                     TGKLVL"
     CDS_motif       8248..8310
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DBP20_RS00360_0001"
                     /evalue="1.90E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="DBP20_RS00360"
                     /protein_end="169"
                     /protein_start="148"
                     /score="26.6"
                     /tool="antismash"
                     /translation="GQRVLIHAAAGGVGHLAVQIA"
     gene            complement(8805..9416)
                     /locus_tag="DBP20_RS00365"
                     /old_locus_tag="DBP20_00365"
     CDS             complement(8805..9416)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007459226.1"
                     /locus_tag="DBP20_RS00365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00365"
                     /product="LysE/ArgO family amino acid transporter"
                     /protein_id="WP_109181317.1"
                     /transl_table=11
                     /translation="MTNALTTAAAGFGTGLSLIVAIGAQNALVLRQGVRRDGVLAVVGI
                     CALSDMVLITLGVAGVGAVVLAWPSALTVVGLLGGLFLIAYGLLAARRVLRPSALHAAD
                     APAPSRRGVVLTCLAMTWLNPHVYLDTVFLLGSVAADQGPLRWTFGLGAILASLCWFVT
                     LGFGARLLSGVLARPSAWRVLDGLVAVMMIGLGAKLLLGA"
     misc_feature    9470..9483
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.27"
                     /tool="antismash"
     gene            9484..10425
                     /locus_tag="DBP20_RS00370"
                     /old_locus_tag="DBP20_00370"
     CDS             9484..10425
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060648.1"
                     /locus_tag="DBP20_RS00370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DBP20_00370"
                     /product="LysR family transcriptional regulator ArgP"
                     /protein_id="WP_109177333.1"
                     /transl_table=11
                     /translation="MMSELPLDQVRTLLAVVDEGTFDAAASVLRLTPSAVSQRVKALEQ
                     RTGRVLLMRTKPVRPTESGEVVVRFARQLSRLERDARTALGMSGPGEPTPLSIAVNSDS
                     LATWFLPALRRVPQELDLAYELRREDQDHTAALLREGLVMAAVTSSPEAVTGCSVRRLG
                     RMRYLPVAEPAFADRWLGRRAGADVRELIEDAPVVGFDRRDDLQDSFVRRLVAGARASS
                     RRHLVPSSEGFASAVAAGMGWGMVPDVQAEPLLREGRLVLLTPDHTVDVPLHWQQWKLD
                     SPALATVAEAVAAEAAETLAGGRPIAPRPLRG"
     misc_feature    10891..10905
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 ccgctcaccg ggcggcccgg aggccagtcg cacccggtcg gcctggaagg cccgcatcgc
       61 ttcctccagc gcgccggcgg gcggcgggcg gccgccggtg cgcagaaacc gggcgcaggc
      121 ggtgcacagc tccgcgaccc ggccgaggag cgcggcggtc tcggggtcgg ccggggcggg
      181 cggggcttct gcgaggatgg ccagctggtc gaggagtctg cgggcggagc ggccggcctg
      241 ttccagtgcg cggtcggtgc gcccggcgcc ggcgggccgt tcggccgggg gtacgtccgc
      301 gaggcgcagg gtcgatccgg cgtcccgcag ccgctgcggt ggtgcgcctg cgggggcggc
      361 cccgcgcgcc gcctcgtcga gggcggcggc cagccgttcc cggtaggagg gtgcggccgg
      421 atcgggcagc aggatctcgc acgcggcgag gagcagggcg ccggccgtga gccccgccag
      481 ccgctccaca agcgtgtcgg gggcgtaggg cgggaagcag gcgaggatgt agaagagctg
      541 gaggccgggg gcgatgccgg ccgggcgggg tccggccacg gccgtgaagg ccagcaggag
      601 tccgatgacg agcatgccgc cgacggcggc ccaggtgtcg acggcgagca gggttcccag
      661 ggtcgccagg accagtgccg ggggcagcgc ccggagcatg acggaggacc gttgggggcc
      721 ggagccgggg accacggaga gcagccccat ggcgatgggc gcgaagagcg cgtacagggc
      781 ggcgaccggg agcccggctc cgtacagcag ggggtagaag cccacgctcg ccgcgacggt
      841 gacccggacg gcccggcgga ggaccgtcgc ccgctgcggc cgggcgatca ccttgccgcc
      901 ccctccgggc gcggctcggg acgggtgctc cgcgaggtcc cggccgggag gagccgctgt
      961 gcgctcatcc ggcacgctcc tctcgtgggg ccgagccctc cggtgcggtg gcccggtcgg
     1021 ccgccttccg ccattgtcgg ccggatcggg ctgcccgcgc gcgacgaagg cgtccgggga
     1081 gcatccgagg tgctcgggcc ggacgccttc ggtgcggggg ccgctcgggg gcggcgcgcg
     1141 tcagatggtc gcggtgtcga tcacgaagcg gtagcggacg tcactcgcga gaacccgctc
     1201 gtacgcctcg ttgacctggt tcgcgtcgat cacctcgatc tcggcgccga gcccgtgcac
     1261 ggcacagaag tccagcatct cctgggtctc cttgatcccg ccgatcgccg aacccgcgat
     1321 cgaccggttg cccaggatca gggagaagag gttcagcgag atcggctcct cgggggcgcc
     1381 cacgttgacg agggtgccct cggtgcgcag caggccgagg taggcgccga agtccagcgg
     1441 ggccgagacc gtggagagga tgacgtcgaa ggttccggcc agttcctcga aggtcttggg
     1501 gtcgctggtc gcgtagtagt ggtcggcgcc cagcttgagc ccgtcgtcct tcttccgcag
     1561 ggactgggag aggacggtga cctcggcgcc gagcgcgtgc gcgatcttga cggccatgtg
     1621 gccgaggccg ccgaggccga cgacggcgac cttcttgccg gggcccgcgc cccagcgctt
     1681 gagcggggag taggtggtga tgcccgcgca caggagcggc gcggcctcgt cgagggcgat
     1741 gccctcgggg atggtgacgg cgaacttctc ggtgacgacg aggtgcgtcg agtagccgcc
     1801 gtaggtgggc tcgccactgc ggtcgagggc gttgtacgtc tgggtgttgc cctcggcgca
     1861 gtgctgctcg cggcccatca ggcaggcgtc gcactgtccg caggagtcga ccatgcagcc
     1921 gacgccgacg cggtcgccga ccttgaaccg ggtgacgccg gagccggtct cggcgacgat
     1981 cccggcgatc tcgtggccgg gcaccatcgg gaagatgccc tcgccccagc cgtcgcgggc
     2041 ctggtggatg tcggagtggc agatgccggc gaacttgatg tcgatcagga tgtcgaactc
     2101 gcccaccgga cgacgctcga tcgtggtgcg ctccagcggg gccttggcac ggggagcggc
     2161 gtaggcggca acggtggtca tgccggaggt tctcctctgg gtgatgcggt aggaacgtgt
     2221 cccagcctca ctccgtgtcc ggtgtttacc caggccaccg ctttgcctat gtccagtggt
     2281 cctactactg acggggacag gctgacccgc ctacgaccac gcggggcagg aataatggaa
     2341 cccatggacg atcagccgga ggccgccgca cccgagccgc tggaccggcg tgcggagctc
     2401 agcgagttcc tgcgcacccg cagggccagg cttcagccgc aggacgtggg actgccggag
     2461 ttcggccggg cccgtcgggt gccggggctt cgccgggagg agctggcgca gctggccggg
     2521 gtgtcggtgg cgtactacac gcgtctggag cagggcaacg ggcgcaatgt gtcggccgag
     2581 gtgctggacg cgatcgcgcg tgcgctgcgg ctcaccgacg ccgagcacgc gcatctgaac
     2641 catctggcga ggccggcccg gcacaagaag aagcgccgcc cggcgaaggt gcagcgggtg
     2701 cggaccgggc tgctgtatct cctcgacagc atggagggca ttcccgcgta cgtggccggg
     2761 gcgcggtccg acatcctcgc ctggaatccg atggcggcgg cggtgttcgg cgactgggcc
     2821 gcgctgccgg cggccgagcg gaactgggct cgcctggtgt tcctctcccc cgcctaccgg
     2881 gacctgttcc tgaactggga ctccaaggcc tcggacatgg tcagctatct ccggctgtac
     2941 gcggggtgcc accccgacga tccgcagttg tcggccctgg tgggcgaact ctcgctcaag
     3001 agcgaggagt tccgccggct gtgggccacg cacaacgtca aggagaaggg ccacggcatc
     3061 aagctgatcc ggcatccgct cgtcggcgac ctgaccctgt cgtacgagac gctgaatctg
     3121 ccggacgacg aggaccagca gttggtgacc taccacgcgg agccggggtc ggaatcggcc
     3181 caggccttgc gcctgctggc gagctggggc gccgacgcgg gacgggcgga tgtgatcagt
     3241 ggtgcgggcc ggagtccgga cgacgagcgg tgaggacgaa ctcccggacg ctacggtccg
     3301 gctgacgact ggtcaggtcg gctccgccgt cagcgctgcc gtctcctccg cctccccgac
     3361 cgcggacgca gcgagtgcgg gggccagggt cgacgccacc gcgcccgtcc cggccgggtc
     3421 caggagcggc agggtcttcg cggcggcgag ccggggcagc agcaactgcc agaaaccggt
     3481 gagccggtac ggggacagcc actcggtgtc gtgacggccg aggacctcga atccggccgt
     3541 cacggcgacg gtcgcggctg ccgcgtcctc gcgggcgatg tcgtcggcga gggttccggc
     3601 ggcggccgcc tcttccagca gctcccgcac gcggtggtgc cactccaacc gcaggtccgg
     3661 ggcggcggcc cgctcgccgt cgcagctcag ccggaatccg gcgcgactca cggggtcccc
     3721 gcgcagcagt tccacgaggg cgtgcgaggt gtcgacgagt gcctgcaggg cggtgtccgt
     3781 cctgcgccgg atcgcggcgg acatgtcgcg cagcccccgg gacgcctccg ccaccacggc
     3841 ttccgcgacc gcggccttgt tctcgaagtg aaagtgcagc gcccccgtgc tgacgcccgc
     3901 gccggagctg atcagcgtca gcctggcctg ggcgtaaccg tgctgttcga agacgacggc
     3961 ggcggagcgg atcagcgcct ggcgggtccg ggtggcgcgc tcctgtttgg tcatggagtt
     4021 atcaaaccaa cttaccggtt tcatttccag ggaacgagac aatgacccat tccctgaccg
     4081 gtcggacagt tcggcagtcg ggcattcggc gcgctttcgc cgagccgggc agccgctcct
     4141 atccggccgc gaacgcgtcc gcgtggtcgg ccgaccaggt gcggtacgtc ctggccccgc
     4201 ggcccgtcag ctcctggacc gtgggcacga tggccgcctt cgcgcccgcc cgctgtcgct
     4261 ccgcgctctc caggaaggct tccgcgacgg gccgcgggta cttcgccagc agggccgcac
     4321 gtgcggcgtc caggcccagt tcctcgaagc gcagcggccg ccccagcacc cgggagagct
     4381 gagcggtctg ttcccgcgcg gtgatcgcct ccgggcccga gacggcgtac gccctgccct
     4441 cgtggccggt gccggtgagg acggcgacgg ccaccgcggc gacgtcgcgg gggtcgatgc
     4501 acgcgaccgg ggcgtcgccg tacagggcgc gcaccactcc cgccgagcgg atgccgggcg
     4561 cccaggacag cgtgttggac atgaacgtcc tggggcggac gaaggtccag gcgatccccg
     4621 actccctgat cgcctcttcg ttctcccgct gacgccgggt gatgaagtcg tcggctcccg
     4681 gttcctccac cgccatcatg gagagcttga ccaggtggcg gacgcccgcc gcgtgggccg
     4741 ccccggcgac ccgctcgtcg tcgggctccg tggggctgtt cgtcaccagg aacagcgagt
     4801 tgacgccccg cagggcccgg tcgagggcgg gacggtcccc gtacgccccc tcgacgacct
     4861 cgaccccgtc cccgcgtacc gtcacgcggt ccgggcggcg ggcgagaatc cgtacgggac
     4921 cggcggccgc cagcagtgcg gcgacctcgc ggcccaccgc tccggtcgca cccgtcacga
     4981 gaatcactgg gaaagacctc tcagccgtcg gcccggggac cggacaggag tgtggagaag
     5041 accggttcgc cgtcctgctg acctgtcacc cggaccgtca ccgtgtcctc ggcctcttcc
     5101 ggctggatca ccgcgctgat ccagcacggg ctgccgaact cggcgtaccg gtggaaccgg
     5161 gtgctcgcct ccgccggaac gatgccgccg ggccccgccg cgaggcaggc cgcctgacgg
     5221 gccgcctcca gcagcagcat gcccggcaca tgatcgttgg ggcgctggaa cagcgtcggg
     5281 tgccgggtgt ccacgcgcag ctcccagacg ccttcgcggc cggtgtccga gagcaccacg
     5341 tcctcggtcc tgctccggcc cgcgcgggcg gcgtcgaccg gcgccgcctc cggtatggat
     5401 atcccctcgg cgggggcgtc gccgcgcatc cgccggtaca ccttggggtt cgtgaagcgg
     5461 gtcgcgccca tgcccgtggc cgccagctcc ccgccccggt gcaccgccca gcccacacgc
     5521 ccctgcacgg gcagcccgct ccgccacttc aggtcggagc agaacacctc cacgtctatc
     5581 tcggtgggag ctccgccgac gcccaagtgg tcctggtggc acacgtagtc caggtccgcc
     5641 atcaggaagt ggtagccgag cggaacgccg tacccggcgt ggaaggcgag catggccgcc
     5701 tgccgcatcg cttcggcgac cagcagcgga tcgtgccggt cgccacccac cggagcgaag
     5761 aacggatgat cgtgcggcag gaccgccgcc accgagaacc gatcgtgcgc cagacggacc
     5821 cagttgcggg gaaacgcgtc ctccggcctg gtccggtgca ccatgtcgat ccccacggga
     5881 tgcaccatgt cggcctccga atccattgcc ggcaccgagt cgatcagggc tgctgcttcg
     5941 ggcataactc cccccagggg tcatgtgatg gcgagccgtt tctgcgatgc acgtgcactg
     6001 ataagataca gactcagcgg ttttttttct atccccggca gggtcgcccc tccccacacc
     6061 gtcccggccg tttcccgggc catccggccc agcaaaggag acaggatggc caagcaggac
     6121 cgggcgatcc gcacccgcca ggcaatcctg atggcagcgg cgcaggcttt cgagaaatac
     6181 ggttatcaag ccgcgacgat caccgaaata ctcaaaagcg ccgacgtgac gaaaggcgct
     6241 ctctattttc attttccgtc caaggaagat ctcgcgctcg gtgttctcca tgcccaggag
     6301 ccgccgcaga ccgttccaga gcagtcactc aaactccagg aactcatcga tctggggatg
     6361 ctgttcagcc accgcctgca gaccagtctc ctcgcccgcg cgggcgtgcg cctctccatg
     6421 gaccagcagg cccagggcct cgaccgcagc ggccctttcc tccgctggca ggaagccacc
     6481 caccacctcc tcgcgcaggc caaacacaac ggtgagctgc tcccccacgt caaccccacc
     6541 gagacggccg acctgtacgt ggccgccttc acgggcaccc aggccgtatc ccagactctc
     6601 accaactacc aggacctgca gcgccgccac atcacgctcc agcagcacat cctgcccagc
     6661 atcgccgcgc cctcgatcct caccgccctc gatctgacgc ccgcgcgcgc cgaacgcctc
     6721 ggccgcctgg ctccggagga ctgaaccggc cgggcgcctg tgcgctcctc atggccgccc
     6781 cgccgcgagg accgcgccac ggaacgtacg ccggtaggcc agtggagtga cgccgatcgc
     6841 ggcgtgcaga tgctggcgca gtgacgcgcc ggtggcgaac ccgacccggc ccgcgatctc
     6901 gtccaccgcc aggtccgtgg actccaggag gtgccgggcc cggtcgaccc gctgctggac
     6961 gatccaccgg cccggactca tgccgacctc ctcgttgaag cgtcggacga aggtgcgccg
     7021 gctcatccgg gcgtgctcgg cgaggctcgc caggctcagc ggctcctgga ggttgcgcag
     7081 cgcccagtcg cgggtcgtgg cggtgtcgtt cgccgccgga gcgggaaccg gctgctcgat
     7141 gtactgggcc tgtcctccgt cgcgccaggg cggtacgacg cagagccggg cgacccggtt
     7201 ggcgatctcg ctgccgtggt ccgcgcggac gaggtgcagg cagacgtcga cgccggaggc
     7261 cgctccggcc gaggtcagga cgcccccgtc gtcgatgaag aggacgtccg ggtcgagccg
     7321 cacctggggg taccaggacc ggaagagctc cgcgagcgcc cagtgggtgg tggcccgtcg
     7381 gccgtccagc agtccggccg aggcgaggag gaaggcgccg gtgcagatgg agacgatgcg
     7441 ggtgccgggg cgtacggccg cgagcgcggc gagggcgtcc gcaggcgcct cccgggtgag
     7501 gagagaggtg tcgaagggcg gaatgacgag ggtgtccgcc gtcgccagca cctcgggacc
     7561 gtgctcgacg gtgatcgaga aatcggcgtt ggtgcgcacg gggcggccgt cgaccgtgca
     7621 ggtcacgacg gagtagcggc cgtcggccgc gccgaggacc cggttgggga tgccgagctc
     7681 gaagggatac accccgtcga gggcgagtac ggcgacgcgg tggacgtttc ccatggcacg
     7741 atcctgtcga aagatggcaa tcatgccatg gtacgccggg cggacaggag tgaggctgga
     7801 cgcatgacga agaacgagag catgcgcgcc atcagccaga gcgtctacgg aggtcccgag
     7861 gtactggagg aggtccggct tccccggccc gtcgcgggac cgagtcagat cacggtcgcc
     7921 gtccgggcgg ccggagtgaa ccccacggac tggaagcacc ggggtcaggg gatgttcctg
     7981 gaccggctgc cgctggtcct gggctgggac gtgtccgggg tcgtggagtc ggtgggcttc
     8041 ggggtgaccc tcttcaagcc gggcgacgag gtgttcggca tgctgcccta cccgtacggt
     8101 gtcggctccc acgccgagtt cgcggtcggc ccggcccgcg ccttcgccca caagccggag
     8161 ggtgtcgacc acgtccgggc ggccgccgtc ccgctcgccg cgctcaccgc ccgacaggcg
     8221 ctggtcgaca cggcggacgt gcgccccggg cagcgggtgc tgatccacgc cgccgccggc
     8281 ggggtgggcc acctcgccgt acagatcgcc aagtcactgg gggcgtacgt catcggcacc
     8341 gcgagcgcgg ccaagcacga tttcgtgcgc gggctcgggg cggacgaggt catcgactac
     8401 cgcaccgtgg acttcgggga cgcggtgagc gatgtcgacg tggtgctcga cccgctctcg
     8461 ggcgagaccc gggcgcgttc gctcgatgtc ctgcgcccgg gaggcacgct cgtgtcgctg
     8521 ctgccgggcg gcgacccggc cgaggcggcg aaggccgccg cgcgggagat ccgggtggag
     8581 aacctgctgg tcgaggcgga tcacgcgggc atgacggcca tcgccgatct gatccgggcc
     8641 ggcgagctgc gcgcccatgt cgaggcgtcc ttcccgctcg ccgaggcggc gaaggcgcac
     8701 gcgctgggcg agacgggccg caccaccggc aagctcgtcc tcgtggtgtc gtagaccgcg
     8761 gggcgcccgg cacctcctcc ccgtgcggaa gaggcgccag gcgttcaggc gcccagcaac
     8821 agtttcgcac ccaggccgat catcatcacg gcgaccaggc cgtccagcac ccgccatgcg
     8881 gagggccgcg cgaggactcc gctcagcagc cgggcgccga acccgagggt cacgaaccag
     8941 cacaggctgg cgaggatcgc gccgaggccg aaggtccagc gcaaggggcc ctggtcggcg
     9001 gcgacggacc cgagcaggaa cacggtgtcg aggtacacgt gggggttgag ccaggtcatc
     9061 gccaggcagg tcagcacgac gccccggcgc gacggggccg gggcgtccgc cgcgtgcagg
     9121 gcggacgggc gcagcacccg gcgggcggcg agcagtccgt aggcgatcag gaacaggccg
     9181 ccgagcaggc ccacgacggt gagcgcggag ggccaggcga ggacgaccgc gccgacgccg
     9241 gcgacgccca gcgtgatgag caccatgtcg gacagggcgc agatgccgac cacagcgagg
     9301 acgccgtccc ggcggacgcc ctggcgcagc accagggcgt tctgggcgcc gatggcgacg
     9361 atgagggaga ggccggtacc gaatccggcg gccgcggtgg tcagggcgtt cgtcatgcgg
     9421 ccgacgctac ggagcatgac aacgcggcgt ccagctaaag attcttacgt atcattagca
     9481 tccatgatgt ccgagcttcc tctcgatcag gtgcgcacgc tgctggccgt ggtcgacgaa
     9541 ggcaccttcg acgcggcggc gagcgtgctg cggctgacac cgtcggcggt cagccagcgg
     9601 gtgaaggcgc tggagcagcg cacgggccgg gtgctgctga tgcggacgaa gccggtgcgg
     9661 cccaccgagt ccggtgaggt ggtggtgcgc ttcgcccgcc agttgtcccg gctggagcgc
     9721 gatgcgcgga cggcgctagg gatgtccggg ccgggcgagc cgacgcccct gtcgatcgcg
     9781 gtgaactcgg actccctggc gacctggttc ctgcccgccc tgcggcgtgt accgcaggag
     9841 ctggacctcg cctacgaact gcgcagggag gaccaggacc atacggccgc cctgctgcgg
     9901 gaggggctgg tgatggccgc ggtgacgtcg tcgccggagg cggtgacggg gtgctcggtg
     9961 cgcaggctcg gccggatgcg gtatctgccg gtcgccgaac ccgcgttcgc cgaccggtgg
    10021 ctggggcggc gggcgggcgc cgatgtgcgc gagctgatcg aggacgcccc ggtggtcggc
    10081 ttcgaccggc gcgacgatct gcaggactcc ttcgtgcgcc ggctcgtcgc cggggcccgg
    10141 gcgagttccc ggcgtcatct ggtgcccagc tcggaggggt tcgcgagcgc cgtggcggcg
    10201 ggcatgggct ggggcatggt gcccgacgtc caggcggagc cgttgctgcg cgagggccgg
    10261 ctggtgctgc tcactccgga ccacaccgtg gacgtaccgc tgcactggca gcagtggaag
    10321 ctggactcgc ccgccctggc cacggtggcc gaggcggtgg cggcggaggc cgccgagacg
    10381 ctcgcgggag gacggccgat tgctcctcga ccccttcgag gttaggttta cctaactcaa
    10441 ctgggaggtg cggaacatga cggatggtca ggatcaggag ccccgcagca acgaggacgc
    10501 gccggtggac tggcaggcac gcggggcctt gtcacggctc gtgctcggtc agatggccac
    10561 gcaggcgctg ggcgcggcgg tgcggttcga cgtcttcgac cggatcgggc cgggcacgct
    10621 gagcgccgac gcgctcgccg aatccctcgg cacccatccg caggccacgc tgcgtctgct
    10681 gcgcgccctg gccggactcc aactgctgtc cgagacggaa ccgggcctct tcaggaccac
    10741 cgcggcgggc gacttcctgc gcaccggcac ggccggctcg atggccgcga tggcccggat
    10801 gttcaccgat ccggtcatgc tgcggggctg ggacctgctc gacgagagcg tgcgcacggg
    10861 ccggaccacg ttcaacacag tgttcggaac cgacttcttc ggccacctca agcagcaccc
    10921 cgaactgtcc gccgcgttca acgag
//
