LOCUS       NZ_CP027862            21146 bp    DNA     circular CON 17-JAN-2024
DEFINITION  Actinomyces sp. Z16 chromosome, complete genome.
ACCESSION   NZ_CP027862
VERSION     NZ_CP027862.1
KEYWORDS    RefSeq.
SOURCE      Actinomyces sp. Z16
  ORGANISM  Actinomyces sp. Z16
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 3761642)
  AUTHORS   Tian,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) State Key Laboratory of Infections Disease
            Prevention and Control, National Institute for Communicable Disease
            Control and Prevention, Changbai road 155,Changping, Beijing,
            Beijing 102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 10:25:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,161
            CDSs (total)                      :: 3,100
            Genes (coding)                    :: 3,019
            CDSs (with protein)               :: 3,019
            Genes (RNA)                       :: 61
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 81
            CDSs (without protein)            :: 81
            Pseudo Genes (ambiguous residues) :: 0 of 81
            Pseudo Genes (frameshifted)       :: 57 of 81
            Pseudo Genes (incomplete)         :: 37 of 81
            Pseudo Genes (internal stop)      :: 10 of 81
            Pseudo Genes (multiple problems)  :: 15 of 81
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:35:34
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2039356
            Orig. end                         :: 2060502
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP027862.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21146
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21146
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21146
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11146](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11146
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(249..1304)
                     /locus_tag="C3B71_RS08445"
     CDS             complement(249..1304)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009233856.1"
                     /locus_tag="C3B71_RS08445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_108967372.1"
                     /transl_table=11
                     /translation="MTPVYGSTRRTGPGGPWSMLRPGPRSALPRMLTWAPLGPRDNTEL
                     AELIARSEAADNPPYRTSAQETAEYFVDPTYSGVAGRDENGVMRAFGLVRLRPAGEIYA
                     SMTGTVDPQWRKRGIGVALLHWQTERARHLIGAERAGEPTGSSTVAVPAHIVTTVLEDD
                     ERMKEHLAELRFEPRRWYREVRRPLSEPIPEVDLDGFLTIEPWSEELDDAVRRAHNQAF
                     ADSGGGSMSPEEWRAGRAYFAPQWSFVALDRSGDRARVAGYALSSRYEQDWEALGWREG
                     YTDVIGVLADYRSRDAGPALLTAVMRAYAADGMEYAAAGFESDDPSGAVDLFLDLGYTA
                     TRGTILYGLDV"
     gene            complement(1357..3618)
                     /locus_tag="C3B71_RS08450"
     CDS             complement(1357..3618)
                     /EC_number="5.6.2.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003918 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006549607.1"
                     /locus_tag="C3B71_RS08450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA topoisomerase IV subunit B"
                     /protein_id="WP_234415854.1"
                     /transl_table=11
                     /translation="MPDSSQSYSARHLSVLEGLEAVRKRPGMYIGSTDQRGLMHCVWEI
                     IDNGVDEALEGYGDRIAVVVHADGSIEVRDTGRGVPVDVEPSSGLTGVELVYTKLHAGG
                     KFGGGSYGSAGGLHGVGASVVNALSARMDVEVDRGGKTYAMSFRRGVPGVFTDTAAGPT
                     PDAPFAEYTEASQLRVIGKVRRGVTGTRVRYWADPEIFPAPAQYDVTALRARLRQTSFL
                     VPGLTLTLTDERDPEAIAATASGAADDPALSVKGGTSPGRATRADKTGKSARSARGAND
                     LFTAGAEDEGAEVFHAEGGTADFVDFLATDGSVTDTFRLTGEGTYTETVQQLDKRTGHL
                     RPTEVERTCTVDVALRWGIGYDTTERSFVNIIATPMGGTHLTGFEQAVTKVLRKQIDAN
                     SRALKVTSRDGRIEKDDILAGLTAVITVRVPEPQFEGQTKEVLGTAPVRQIVAKVVEKE
                     LTALLTSSKRDLKTQSRALQEKIVGEMRARVSARMHKEITRRKTALETSTLPAKLADCR
                     SDDVASSELFIVEGDSALGTAKNARNSEFQALLPIRGKILNVQKASQADMLRNAECSAI
                     IQVVGAGSGRTFDLDAARYGKVILMTDADVDGAHIRTLLLTLFFRYMRPMIEAGRVFAA
                     VPPLHRIEVSAQGRRKREVIYTYSDEELVTTLRKLEKQGRSFKEPQRYKGLGEMDAHQL
                     AETTMEPEHRTLRRITLGDEAELLEAENVFELLMGSSVEPRRDFIIEGAAEVDRERIDA
                     "
     gene            3813..4091
                     /locus_tag="C3B71_RS08455"
     CDS             3813..4091
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009749741.1"
                     /locus_tag="C3B71_RS08455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_073331654.1"
                     /transl_table=11
                     /translation="MSTTTPISPTVADPTTAPEQATGPTAATETRPLTTADRCDVCGAQ
                     AYLRVVLASGELLFCAHHGHAHRDALERQALFIQDESDRLTRSDEVD"
     gene            complement(4111..4953)
                     /gene="thiD"
                     /locus_tag="C3B71_RS08460"
     CDS             complement(4111..4953)
                     /EC_number="2.7.1.49"
                     /EC_number="2.7.4.7"
                     /GO_function="GO:0008902 - hydroxymethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008972 - phosphomethylpyrimidine kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017178456.1"
                     /locus_tag="C3B71_RS08460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional hydroxymethylpyrimidine
                     kinase/phosphomethylpyrimidine kinase"
                     /protein_id="WP_108967376.1"
                     /transl_table=11
                     /translation="MNTPIPKALTIAGSDPSGGAGVQADLKTMGALGTYGMSVVTALTA
                     QSTRGVAGVRAVPVDFVRLQLDALLADITPDATKVGMLATAELAEAVGEYLPDLANTVL
                     DPVMVATSGDRLLDAEAIGAVRRLCARADLITPNLDEAAALLDRSPAASTDAMRRQAEL
                     LLDAGARRVLLKGGHLGADATDVYADADGTLLLPGRHVDTRNTHGTGCTLSAAIAALRP
                     QRESWITAVRDAKGYLTGALTHADALGVGHGHGPVHHYYALWPSRPEGVGSRLRQAGG"
     gene            complement(4950..5606)
                     /gene="thiE"
                     /locus_tag="C3B71_RS08465"
     CDS             complement(4950..5606)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006680514.1"
                     /locus_tag="C3B71_RS08465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_073331648.1"
                     /transl_table=11
                     /translation="MRPAPDLRVYLVTDAAQCRARGRTVTDTVRAAVAGGATCVQVRAK
                     DADGADFLAQVCDVANAVGELVPVLVNDRVDVYLAARRLGAPVAGVHVGQRDLPATVVR
                     ELIGDDAYLGLSAANPEALSAAAAEGACDHVGVGAVRATATKADAPTGIGTDGVSRLAA
                     DIALPCVAIGGITPADLPALRAGGLAGAAVVSAICLADDPRAAARRLRRAWEAAR"
     gene            complement(5603..6475)
                     /gene="thiM"
                     /locus_tag="C3B71_RS08470"
     CDS             complement(5603..6475)
                     /EC_number="2.7.1.50"
                     /GO_function="GO:0004417 - hydroxyethylthiazole kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006680515.1"
                     /locus_tag="C3B71_RS08470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxyethylthiazole kinase"
                     /protein_id="WP_108967378.1"
                     /transl_table=11
                     /translation="MAQHVSVNTQPNEPPPQSTGPAAAAPSPGPAAVLESLRAEGPLVA
                     CITNAVVTNFTANVLLAAGAAPAMVDVTGEAGPFASAASALLINLGTPQPEQRAAAVEA
                     ATAARMAGVPWVLDPVAVGTLVHRTALAQRLLEERPTVIRGNASEIIALAGAGAGGRGV
                     ETTAAVETALDAARSLAARTGAVVAISGPVDAVVDGARVSRVGGGSVLLTRVTGGGCAL
                     GALAAGFLAAGTAIGTDAFAATVACHAAYSAAAEIAAATAAGPGSFPPAFLDALYALDA
                     DDVARIPIS"
     regulatory      complement(6465..6553)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(6494..6508)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.5"
                     /tool="antismash"
     gene            complement(6710..7300)
                     /locus_tag="C3B71_RS08475"
     CDS             complement(6710..7300)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C3B71_RS08475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_146750790.1"
                     /transl_table=11
                     /translation="MNHNRLTGFLSSKGLSLRKMDDNHYVDFFSCGRDDKMDRWLSDTA
                     LKWQREDMCAVWVLSPASDDTDVWGFFTLSAHQIIPSNVAKTDKAFVGSNREWVYNLNN
                     PFPAQLLGKFALDRGHQGRGLGEVLMLCAYAKHVEAADIAGSKFLVLDVRDDKLVSYYQ
                     DRYGFVRSSRVNGGAQMYRPTWVIRKELEEALA"
     misc_feature    complement(7178..7180)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7297..7893)
                     /locus_tag="C3B71_RS08480"
     CDS             complement(7297..7893)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024671.4"
                     /locus_tag="C3B71_RS08480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II toxin-antitoxin system antitoxin SocA
                     domain-containing protein"
                     /protein_id="WP_146750789.1"
                     /transl_table=11
                     /translation="MTTVFDVATELIERSGGSIETVKLQKLCFYAFGWYAHLTGEPLFG
                     ETFYAMPKGPVVGELLSAHAGKAHADLSMIEDQRKEREDDRDELDAYKTAVLDAVWSAY
                     GGKTSRDLVELTHEESVWDDAWKARPTGTKRGDLTRADMIAYFLGRTPKSDETLDGLPP
                     AMVLPASATELAAIESRAEVHRPFVDAVRAFRFAS"
     misc_feature    complement(7393..7395)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    7887..7901
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.38"
                     /tool="antismash"
     gene            complement(8119..9798)
                     /locus_tag="C3B71_RS16455"
     CDS             complement(8119..9798)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008733797.1"
                     /locus_tag="C3B71_RS16455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_073331645.1"
                     /transl_table=11
                     /translation="MATSTVAPAPTTARERVEFADDVDEALEEKQDVDLDDLDEDEDLA
                     QDEDDDLVEDDVDADDVDSEDDDEPEDSEDEGDDEPEAAAPAPELRDYYLDVSLEENGD
                     GTKRHPFNTPAALKDVRLAPGATLFVRSRTVVEGLEINGDGTLEDPITLAPYGHGPVPR
                     FVIPGEEEPVVAREFLTQNGYIFRGWIIKGIKMNPSIAALTGELDRIRREEAEKAANKK
                     SRKSKGEKGKDGSFTVSDSDEGDEPAQKVVTAGATADPVKDYLKQIGKVALLNAAQEVE
                     LAKRIEAGLYAEHLLATEGNDMDAKYRRELHWVAQDGQRAKNHLLEANLRLVVSLAKRY
                     TGRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIP
                     VHMVEVINKLARVQRQMLQDLGREPTPEELAVELDMTPEKVVEVQKYGREPISLHTPLG
                     EDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHAVLDTLSEREAGVVSMRFGLTDGQPK
                     TLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLDD"
     gene            10001..11146
                     /locus_tag="C3B71_RS08490"
     CDS             10001..11146
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009749747.1"
                     /locus_tag="C3B71_RS08490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_108967385.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 7.1e-43, bitscore:
                     144.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVDALLPLVRGAVDARLDEVLARLRAQWQDSPAVTDELLEAAA
                     TALAGGKRMRAVLGAVGLTLAGGDADPAAVAAGPTAARLGAALELYQASALVHDDVIDA
                     ADTRRGQPAAHRRYAARHRRAGWTGSADVYGVSAAILLGDLLMSAATAQLGQATAGCER
                     GAARAARDAFDAMTAEVAVGQFLDVHQEVMPLPAPTDRPVAAGAAMREAALEVIRHKSA
                     RYSVMYPLQVGALLAGVAPHGELLTALEVFGEEIGIAFQLRDDVLGVFGDPALTGKPAG
                     DDLREGKRTVLVALAWQRCNNAGRKLLTRVLAGDEAATAADLAAAAALIRDCGALNAHE
                     DEIAAHTATGLAALEAAPGALPERSRRTLLGLAEMLTARRS"
     gene            11205..13256
                     /gene="pknB"
                     /locus_tag="C3B71_RS08495"
     CDS             11205..13256
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009749748.1"
                     /locus_tag="C3B71_RS08495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_108967387.1"
                     /sec_met_domain="Pkinase (E-value: 3.8e-45, bitscore:
                     151.8, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKDPLIGRLVDARYEIVDRVARGGMATIYRAHDRRLDRMVALKL
                     MHPHLADSPDFVARFRREARAAARLSNPGVVAVYDQGSLDGIAYLVMELVEGPNLRDLI
                     ASGPLTVREALGLTAQILGPLGAAHRAGLVHRDVKPENVLLPADGSVAKVADFGLARAV
                     TEVAQTTTGNVLGTVAYLAPELITTGSSAPCADVFSVGVILYELLTGVQPFEADTPIQI
                     AFRNVHEDIPAPSLRVPDLPESVDELVAAMTRRDPHSRLDDADAALDRLRQIVSTLSEA
                     ELAVKRGGATGSVRTQEVLAANAEAARTAMLVTDGTESDADAAEAAADAATPGAGLRTV
                     SLPIGSIAPDGAAGGRDGTTRALDRSRLSRGADTQNTQPVARHSARRPRRRAVIAAALL
                     LAAAGSGGAWYLTAGPGRTVPVPQIVGMSAQDAQDAVEAAGLVWGAPTRAYSDTVPADS
                     VISCSPGADTRLHPGQAVTPVISRGIEQKVVPDVVGSTQEDATSAIVDAGLTLGAVTKT
                     YSDDVASGMVISCEPQSGSTVDHSSAVAIVVSLGRQPATVPDVTGMSVEDATTTLEAAG
                     LTLGTQSEAYSDDVASGMIISSSPASGAEGYHHGDAVDVVVSKGPEKVSVPDVVGMSER
                     EAVTALEDAGLDPQVSRVMGGLFDTVHSTDPSAGQSVEKGSQVTVNVI"
     gene            complement(13269..14612)
                     /locus_tag="C3B71_RS08500"
     CDS             complement(13269..14612)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009405517.1"
                     /locus_tag="C3B71_RS08500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-deoxy-7-phosphoheptulonate synthase class II"
                     /protein_id="WP_108967389.1"
                     /transl_table=11
                     /translation="MMNELQVPGGAAGWRQHHAAQQPRYPDPQALADAAADLRTRPPLV
                     FAGEVDSLREKMVLASQGRAFVLMGGDCAESFHDNTAVNIRLKLQTILQMAAVLTYGAS
                     TPVVKIGRMAGQYAKPRSSDTETRDGVTLPSYRGDSVNDHAFTAEARIPDPQRMVDAYL
                     RAGTTLNLIRSFTMGGYADLREVHSWNRGFTANPAYKRFESFAEEIDRAMRFMEAAGVD
                     FEALRQVDFYAAHEALLLEYEDAMTREDSRSGRLYDTSAHFLWVGERTRGADDAHVALL
                     AGVHNPVGVKIGPTTTRDELLSLIDHLNPDGDPGRLSLITRMGADRIRDVLPPLVEIVR
                     ADGRPVTWITDPMHGNTITSENGYKTRRFDTIMDEVRGFFEVHRALGTVPAGIHVELTG
                     DDVTEVLGGGEHIDEAGLARRYETLVDPRLNHQQSLEMAFEVAEMLRG"
     gene            complement(14799..16031)
                     /locus_tag="C3B71_RS08505"
     CDS             complement(14799..16031)
                     /EC_number="2.7.1.90"
                     /GO_process="GO:0006002 - fructose 6-phosphate metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008733723.1"
                     /locus_tag="C3B71_RS08505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrophosphate--fructose-6-phosphate
                     1-phosphotransferase"
                     /protein_id="WP_073331636.1"
                     /transl_table=11
                     /translation="MSIRRVALLTAGGFAPCLSAAVGDLIERYTEVAPDVEIIAYQYGY
                     HGLLTGNYVVIDEEGRKNAGVLRQYGGSPIGNSRVKLTNAKNLVERGLVKEGVDPLAFA
                     AERLREDGVDVLHTIGGDDTNTTAADLAAYLRDHDYDLTVVGLPKTIDNDIVPIRQSLG
                     AWTAAEQGAGFALNVIGEHRSNPRMLIVHECMGRNCGYLTAETARRYHELLKDRQWAPS
                     LGLTKERWDVHAVFVPEAKLDIAAEAERLKAIMDEQGNVNIFLSEGAGVPEIIAEMEAK
                     GEEVQRDPFGHVKLDTINPGQWFARQFADKIGAEKVMVQKSGYYSRAAAANEEDLALIK
                     QMCDLAVDCALRGEPGVIGQDEENGDQLGAIAFERIAGGKPFDITQQWFVDLMAELGQN
                     LEPAAATDGEA"
     misc_feature    16138..16152
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            16226..16684
                     /locus_tag="C3B71_RS08510"
     CDS             16226..16684
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037100.4"
                     /locus_tag="C3B71_RS08510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_108969722.1"
                     /transl_table=11
                     /translation="MTQRAERDWIRFRRHAAGLSQRELADRTGVTQPLIAAIESGARRP
                     SADTRERPRKALQVRPSVLLRAGRKEAIALAGSHGCEVIGAFGSVTSGEDRPDSDIDLL
                     VRFPPDADILILLELEEELSDLLTVPVDVISVGSGPATTTGASLGRVV"
     misc_feature    16394..16396
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16989..17270)
                     /locus_tag="C3B71_RS08515"
     CDS             complement(16989..17270)
                     /GO_component="GO:0110001 - toxin-antitoxin complex
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014643.4"
                     /locus_tag="C3B71_RS08515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II toxin-antitoxin system Phd/YefM family
                     antitoxin"
                     /protein_id="WP_199912482.1"
                     /transl_table=11
                     /translation="MSVDAFMPLRDVKNHLSEVVSQVERERSRVTITRRGRPAAVVISV
                     DGPESVEETLDILSRPALIERIRAGADDLGAQRVETLGKDELVDSQKG"
     gene            17352..17960
                     /locus_tag="C3B71_RS08520"
     CDS             17352..17960
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017194557.1"
                     /locus_tag="C3B71_RS08520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_108967392.1"
                     /transl_table=11
                     /translation="MRRTAAEAAETRKAIIHSALHRFAQDGWEGCSLVEVARGANVTRG
                     AVYHHFTGKRELLDAVLAEQWHSRGEALLAVLDTSAPPEARLTTFLADYLRRLREDTDF
                     RELAVVTVLVASQAPAVKSGLEQKTASLAQWSEQIVRLLATCEPRLRVPLDIARFTITT
                     FLHGATLTAALMPEDLPEPGRCETTARALVAGLINIESP"
     gene            17980..19209
                     /locus_tag="C3B71_RS08525"
     CDS             17980..19209
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008730439.1"
                     /locus_tag="C3B71_RS08525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_234415855.1"
                     /transl_table=11
                     /translation="MQPTPSDATTSPRMAVVVACVALFTDMLVYGILIPVLPLLPAMAE
                     AGPSATGLLFAAYAAALVMVTPIAGRVVDKRGSRGPLLAALVGLACACLLFTIGGPYWL
                     LLTARTLQGAAAGLSWVAGLSLIAATVPLQRRATYLGLAMSMVSVGALAGPPLAGWLAG
                     LGGHSAPFLLAAVLLMIDGALRLAFVRPTSPPSDDPATALDVLRTPGCWPVVALILIGA
                     AVTSCIEPVLPMQLAREFGVGSAGIGMLFALLTLVAACLNPLVGACLPRVSLRALTLVG
                     AASAAAGLLLVGVGPNLPVITAGLVCLGSAIALLVAPASALIGVQGAMATPPAIGGAYS
                     LYNLAYAGGLVLGPALSGPLTEHLGFTHACLTLAGFLALTVPTFIRLPRKYAAATAESV
                     QIRDRRGQHP"
     gene            complement(19309..20205)
                     /locus_tag="C3B71_RS08530"
     CDS             complement(19309..20205)
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004565056.1"
                     /locus_tag="C3B71_RS08530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_108967396.1"
                     /transl_table=11
                     /translation="MGYRGIKAAVGPAMEMLYQPWIRGEENIPAEGPAILASNHLAVID
                     SFFLPLLMDREVAFIGKSDYFTGKGIKGWAVKNFMTAVGTIPVDRSGGKASMAALQAGI
                     DRLRSGELFGIYPEGTRSPDGRLYRGKTGVARVALATGAPVIPVAMIGSNLAQPIGQVV
                     PSTRHRVGIVIGEPLDFSRYQGLENDRFVLRSITDEIMYALMSLSGQEYVDLYAADVKK
                     AMDAEKKTAAEVVDEMLEELAAKRPAAAPVEAPGGRPAPDVEVPEPPAEPDKAEDDEGT
                     EASEDDAAENAPRPDDD"
     misc_feature    complement(20672..20681)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(20834..20848)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.58"
                     /tool="antismash"
     misc_feature    20835..20849
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
ORIGIN
        1 tctgcatggc cacactgatg ccacgggagc gcagtaggcg gcccaggctg gaggcggtca
       61 atcccttgcc gagggaggac acgacaccgc cggtgacgaa gatgtgatga gggacggcgg
      121 gggtcttccc gcccggacgt gcaggtgcgt tactcacggg ccttcaacgt agcaccggga
      181 cgaaacgcgc ccgacgcata cgcccaccgg cggcccgccc cggccggttg ggccgcgggc
      241 accggcggct acacgtccag gccgtacagg atcgtgccgc gcgtggcggt gtaccccagg
      301 tcgaggaaca ggtcgacggc gccgctcggg tcgtctgact cgaagccggc cgccgcatac
      361 tccatgccgt cggcggcgta ggcgcgcatg accgccgtca gtagtgccgg gccggcgtcg
      421 cgggaacggt aatcggcaag caccccgatg acgtcggtgt agccctcccg ccagccgagt
      481 gcctcccagt cctgctcgta gcggctggag agcgcatagc cggcgacccg ggcacggtct
      541 cccgaccggt ccagtgccac gaagctccac tggggtgcga agtaggcgcg cccggcccgc
      601 cactcctccg ggctcatgct gccgccgccg gagtcggcga aggcctggtt gtgggcgcgg
      661 cgcacggcgt cgtcgagttc ctccgaccag ggctcgatgg tgaggaagcc atccaggtcc
      721 acctccggga tgggctcgga gagcgggcgg cgcacctccc gataccagcg gcgcggttcg
      781 aagcgcagct cggccaggtg ctccttcatg cgttcgtcat cctccagcac ggtggtgacg
      841 atatgggcgg gcactgcgac cgttgaggag ccggtcggct ccccagcgcg ctcggcgcca
      901 ataaggtgcc gggcccgttc ggtctgccaa tgcaacagcg ccaccccgat gccgcgcttg
      961 cgccactgcg ggtcgaccgt cccggtcatg gaggcgtaga tctctccggc cggccgcagt
     1021 cgcaccagtc cgaaggcacg catgacaccg ttctcgtcac ggccggccac ccccgagtag
     1081 gtggggtcca cgaagtactc ggcggtctcc tgggcactgg tgcggtatgg ggggttgtcc
     1141 gccgcctcgg aacgggcgat gagctcggcc aactcggtat tgtcgcgcgg ccccagcggc
     1201 gcccaagtga gcatgcgggg cagcgcggaa cgaggtccgg gacggagcat cgaccaggga
     1261 ccgcccgggc cggtgcggcg cgtagagccg taaacaggtg tcatgtgcgt ctccttcgac
     1321 gggaccgggc cgacattaag ggtacgggca aatggctcag gcgtcgatgc gttcgcggtc
     1381 gacctcggcg gcgccctcga tgatgaagtc gcgccgcggc tccacgctgg aacccatgag
     1441 cagctcgaac acgttctccg cctcaagcag ctcggcctca tcgcccaggg tgatgcgccg
     1501 cagggtgcgg tgctcgggct ccatggtggt ctcggccagc tggtgggcgt ccatctcccc
     1561 caggcccttg tagcgctgcg gctccttgaa gctacgaccc tgcttctcca gcttgcgcag
     1621 ggtggtgacc agctcctcgt cggagtaggt gtagatgacc tcgcgcttgc gccggccctg
     1681 agcggaaacc tcgatgcggt gcagcggggg gacggcggcg aagacccggc cggcctcgat
     1741 catggggcgc atgtagcgga agaagagggt gagcagcagg gtgcggatgt gggcgccgtc
     1801 gacgtcggcg tcggtcatga ggatgacctt gccgtagcgg gcggcgtcca ggtcgaaggt
     1861 gcgcccggag ccggccccga ccacctggat gatggcggaa cactcggcgt tgcgcagcat
     1921 gtccgcctgg gaggccttct ggacgttgag gatcttgccg cggatgggca gcagcgcctg
     1981 gaactcgctg ttgcgggcgt tcttggcggt gcccagggcg gagtccccct caacgatgaa
     2041 cagctcggag gaggcgacgt cgtcggagcg gcagtccgcc agcttggcgg gcagggtgga
     2101 ggtctccaga gccgtcttgc ggcgggtgat ctccttgtgc atgcgggcgg acacgcgggc
     2161 gcgcatctcc ccgacgatct tctcctgcag ggcgcgcgac tgcgtcttca ggtcccgctt
     2221 ggaggaggtc agcagggcgg tgagttcctt ctccaccacc ttggcgacga tctgccgcac
     2281 gggagcggtg ccgagcacct ccttggtctg cccctcgaac tggggttcgg gtacacgcac
     2341 ggtgatgacg gcggtgagcc cggcgaggat gtcgtccttc tcgatacgcc cgtcgcgact
     2401 ggtgaccttc agggcgcggg agttggcgtc gatctgcttg cgcagcacct tggtgacggc
     2461 ctgctcgaag ccggtcaggt gggtgccgcc catgggggtg gcgatgatgt tgacgaagga
     2521 gcgctcggtg gtgtcgtagc cgatgcccca gcgcagggcc acgtcgacgg tgcaggtgcg
     2581 ttcgacctcg gtgggccgca ggtggccggt gcgcttgtcg agctgctgca cggtctcggt
     2641 gtaggtgccc tcgccggtca ggcggaaggt gtcggttacg gatccgtcgg tggccaggaa
     2701 gtcgacgaag tcggcggtgc cgccctcggc gtggaagacc tctgccccct catcctcggc
     2761 gccggcggtg aacaggtcat tggcgccgcg cgcggacctg gccgacttgc ctgttttatc
     2821 cgcccttgtc gcccggccgg ggctcgtccc acccttgacg ctcaaggccg ggtcgtcggc
     2881 ggcaccactg gcggtggcgg cgatcgcctc cgggtcgcgc tcgtcggtga gggtgagggt
     2941 gagcccgggc accaggaagc tggtctgccg cagtcgggcc cgcagagcgg tgacgtcgta
     3001 ctgcgcggga gcggggaaga tctcggggtc ggcccagtag cgcacccggg tgccggtgac
     3061 gccgcggcgc accttgccga tcacgcgcaa ctgggaggcc tcggtgtatt ccgcgaaggg
     3121 agcgtccggg gtggggcccg cggcggtgtc ggtgaagaca ccgggcacgc cccgtctgaa
     3181 gctcatggcg taggtcttgc cgccgcggtc cacctccacg tccatgcggg cggacagggc
     3241 gttgaccacg ctggcgccca ccccgtgcag gccacccgcg gagccgtagg agccgccgcc
     3301 gaactttccg ccggcgtgca acttggtgta gaccaactcg acaccggtca gcccggagga
     3361 gggctcgacg tccacgggca cgccccgccc ggtgtcacgc acctcgatgg agccgtcggc
     3421 atgcacgacg acggcgatgc ggtccccgta gccctccagg gcctcgtcca cgccgttgtc
     3481 gatgatctcc caaacgcagt gcatcaggcc ccgctgatcg gtggagccga tgtacatgcc
     3541 agggcgcttg cgcaccgcct cgagcccctc aagaactgag aggtggcggg ctgagtagga
     3601 ctgggaagaa tctggcacgg gccgaattta gccgattgtt ggggcgggtc aggcatcccg
     3661 cgccgtcgcc ggaggtgtgg tcttcgcccg tagccggagg atcggggccg ccgctgattc
     3721 ccgccgttcg ccgtgggcgc aggcggtgcg cccggggcgg aaaaccgccc gacggcgttg
     3781 gcgtgggctc ccggtggtgg tggaatcgag ccatgagcac gacaactcca atctccccca
     3841 cggtcgccga tccgacgacc gcgcccgaac aggccaccgg ccccaccgcg gcgaccgaga
     3901 cgcgtccgct caccacggcc gatcgttgcg acgtctgcgg cgcacaggct tacctgcgcg
     3961 tggtcctcgc ctccggcgag ctgctgttct gcgcccacca cggccacgcc caccgggacg
     4021 ccctggagcg ccaggccctg ttcatccagg acgagtccga ccgcctgacc cgctccgacg
     4081 aggtcgacta accgattggc gacgaccggc tcacccgccg gcctgcctca gcctgctgcc
     4141 tacgccctct ggccgactcg gccagagggc gtagtagtgg tgcacggggc cgtgcccgtg
     4201 gccgacgccg agcgcgtcgg cgtgcgtgag ggctccggtc aggtagccct tggcatccct
     4261 taccgccgtt atccagctct cccgctgcgg gcgcagcgcc gcaatcgccg cggagagcgt
     4321 gcagcccgtg ccgtgcgtgt tgcgggtgtc cacgtggcgg ccgggcagca gcagcgtgcc
     4381 gtccgcatcc gcatacacgt cggtggcgtc cgcgccgagg tgcccgccct tcagcagcac
     4441 ccggcgggca ccggcgtcca ataggagctc cgcctggcgg cgcatcgcat cggtgctcgc
     4501 ggccggtgaa cggtccagca gggcggcggc ctcgtccagg ttcggggtga tcaggtccgc
     4561 acgcgcgcac aggcgcctga cggcgccgat ggcctcggca tcgagcagcc ggtccccgga
     4621 ggtggccacc atcaccgggt ccaggacggt gttggccagg tcgggcaggt actctcccac
     4681 cgcctcggcc agttcggcgg tggcgagcat gccgaccttg gtggcgtcgg gggtgatgtc
     4741 cgccagcagg gcgtccagct gcaggcgcac gaagtccacg ggcacggccc gcactccggc
     4801 gactccgcgc gtggactggg cggtcagtgc cgtgaccacg ctcatgccgt aggtgccgag
     4861 cgcccccatg gtcttcaggt ccgcctggac gccggcgccc ccggaggggt cggagccggc
     4921 gatggtcagt gccttgggga tcggtgtgtt catcgcgcgg cctcccaggc ccggcgcagc
     4981 cgccgggcgg cggcgcgcgg atcgtccgcc aggcagatcg cggagacgac ggcggccccg
     5041 gccagtcccc cggcgcgcag agcgggcagg tcggcgggcg taatgccgcc gatggccacg
     5101 catggcagcg caatgtcggc cgccaggcgg ctgacgccgt cggtgccgat gcctgtgggc
     5161 gcgtcggcct tggtggcggt ggcacgtacc gcgccgacgc ccacgtggtc gcaggcgccc
     5221 tccgctgccg ccgcggaaag tgcctccggg ttggccgcgg acaggcccag gtaggcgtcg
     5281 tcgccgatga gctcgcgcac cacggtggcg ggcaggtcgc gctggcccac gtgcacgccc
     5341 gccaccggcg cccccaggcg gcgggcggcc aggtacacgt cgacccggtc gtttacgagt
     5401 accgggacca gctcaccgac ggcgttggcg acgtcgcaga cctgggcgag gaaatcggcg
     5461 ccgtctgcgt ctttggcacg cacctgcacg caggtggcgc cgccggccac ggcggccctg
     5521 accgtgtcgg tgacggtgcg gccgcgcgcg cggcactggg cggcgtcggt gaccaggtag
     5581 acccgcaggt cgggggcggg cctcatgaga tcggaatcct ggcgacgtcg tcggcgtcca
     5641 gggcgtacag ggcgtcgagg aatgcgggcg ggaaggagcc tgggcccgcg gccgttgccg
     5701 cggcgatctc ggcggcggca ctgtaggcgg cgtgacaggc gacggtcgcc gcgaaggcgt
     5761 cggtcccgat ggcggtcccg gcggctagga agcccgccgc cagcgcgccc agggcgcagc
     5821 cgccgccggt gacgcgggtc agcagtacgg agccgccgcc cacccggctc acgcgtgcac
     5881 cgtcgacgac ggcatccacg ggcccggata tcgccaccac ggcgccggtg cgcgccgcga
     5941 gcgaccgggc ggcgtccagg gcggtctcca cggcggcggt tgtctccacc ccgcggccgc
     6001 ccgcaccggc gccggccagg gcgatgatct ccgaggcgtt gccgcggatg accgtggggc
     6061 gttcctccag gagccgttgg gccagggcgg tgcggtgcac cagggtgccg acggcgaccg
     6121 ggtcgagcac ccagggcacg cccgccatcc gcgcggcggt ggcggcctcc acggcggcgg
     6181 cacgctgctc gggctggggt gtgcccaggt tgatcagcag ggcggaggcg gcggaggcga
     6241 agggcccggc ctccccggtg acgtcgacca tggcgggggc ggccccggcg gccagcagca
     6301 cattggcggt gaagttcgtg accaccgcat tggtgatgca ggcgaccagg gggccctcgg
     6361 cgcgcaggga ctccagcacg gccgcgggtc ccggagacgg cgccgcggcc gccggccccg
     6421 tcgactgtgg cgggggctcg ttcggttggg tgttgacgga cacgtgctgc gccatgcgac
     6481 atcccttcgt cagcattatc tgaacaggtt caacgggttt gttctcagcc ttgcggcacc
     6541 ccgtgtcgtg ggcacaacga tagcaaacga cacgccgctc acgcacgtca tgcgatcctt
     6601 ggccaacatt gagcggtcct agtcagatta tgaagcaccc caggggctag ctctcgttcc
     6661 cctccgcaga ctaagcgctc agctttctca tcagtagaag ggccgaaact cacgcaagag
     6721 cttcttcgag ctcctttcgg atcacccacg taggtcggta catctgcgca ccaccattta
     6781 cacggctgga tcgaacgaag ccgtagcggt cctggtagta agacaccaac ttgtcgtccc
     6841 gtacatccag cacgaggaac ttgctccccg caatatcagc cgcctccacg tgcttggcgt
     6901 acgcacagag catcagaact tcacccaaac ccctgccctg atgaccccga tcaagggcga
     6961 acttaccaag caactgagcc gggaagggat tgttcaggtt atacacccac tccctgttgg
     7021 aacctacgaa cgccttatcc gtcttggcca cgttactcgg gatgatctgg tgggcgctga
     7081 gcgtgaagaa gccccataca tcggtatcat cactagccgg agagagcacc cacaccgcgc
     7141 acatgtcttc acgctgccat ttcaacgcag tgtcacttaa ccaccggtcc atcttgtcgt
     7201 cgcgcccgca actgaagaaa tcgacgtaat gattgtcgtc catcttccga aggctcagcc
     7261 ccttactgga aagaaagcca gtcaagcggt tgtgattcat gacgcaaagc ggaaggcacg
     7321 taccgcatca acgaaggggc gatgcacctc tgctcgggat tcaatagcag ccagttctgt
     7381 tgccgaggcg ggtaagacca tcgcgggagg cagcccgtca agcgtctcgt ccgacttcgg
     7441 cgtgcgaccg agaaagtaag caatcatgtc cgcacgcgtc agatcgccgc gcttcgtacc
     7501 tgtaggccgc gccttccagg catcatccca aacagactcc tcgtgcgtga gttcgacgag
     7561 atcccgactc gttttgccac catacgccga ccagacggcg tccagaacgg ccgtcttgta
     7621 cgcgtccagc tcgtcccggt cgtcctcacg ctccttgcgc tggtcctcga tcatggagag
     7681 gtcagcatgc gcctttccgg catgggcact gagcagctcg ccaactaccg gccccttagg
     7741 catggcgtag aaggtctcgc cgaacagtgg ctcgcctgtc agatgtgcgt accaaccgaa
     7801 ggcgtagaaa cagagcttct gcagcttcac agtctcaatc gagcctccac tgcgctcaat
     7861 caactctgtt gcgacgtcga agaccgtggt catggtgttc acctcccgaa gccagatgcg
     7921 gttgatacta ccaagcggca agactccaat cacgtgggct cagtctcacc ccgctgccca
     7981 aatcacgata ctgctggcaa acaactggcc gataccccgc gatgaggaac ttcgacgcag
     8041 ccgaccctgc taagccgccc cggaaccggt cagttccggg gcggccgagc cgtgtaggaa
     8101 tgagggcttg ccgtcgcctc agtcgtccag atagtcgcgc agcacctggg agcggctggg
     8161 gtgacgcagc ttgctcatgg tcttggactc tatctgcctt atacgctcgc gggtcacccc
     8221 atagaccttg ccgatctcgt ccagcgtctt gggctgaccg tcggtcaggc cgaagcgcat
     8281 ggagaccacg cccgcctccc gctcggacag ggtatccagg acggcgtgca gctgctcctg
     8341 cagcagcgtg aagctgacgg cgtccgcggg gacaaccgcc tcggagtcct cgatcaggtc
     8401 accgaactcg ctgtccccgt cctcaccaag cggggtgtgc agggagatgg gctcgcgccc
     8461 gtacttctgc acctcaacga ccttctccgg ggtcatgtcc agttcgacgg cgagctcctc
     8521 cggagtgggc tcgcggccca ggtcctgcag catctgccgc tggacacggg cgagcttgtt
     8581 gatgacctcg accatgtgga cggggatgcg gatggtgcgc gcctggtccg ccatggcgcg
     8641 ggtgatggcc tggcggatcc accaggtggc gtaggtggag aacttgtagc ccttggtgta
     8701 gtcgaacttc tccacggcgc ggatcaggcc caggttgccc tcctggatca ggtccaggaa
     8761 gagcatgccg cggccggtgt agcgcttggc cagggagacg accaggcgca ggttcgcctc
     8821 cagcaggtgg ttcttggcgc gctgaccgtc ctgggccacc cagtgcaact cgcggcggta
     8881 cttggcatcc atgtcgttgc cctcggtggc cagcaggtgc tcggcgtaca ggcccgcctc
     8941 gatgcgcttg gcgagctcga cctcctgcgc ggcgttgagg agcgcgacct taccgatctg
     9001 cttgaggtag tccttgacgg ggtcggcggt ggcgccggcg gtgacgacct tctgtgcggg
     9061 ctcgtcgccc tcatcggagt cggagaccgt gaaggagccg tccttgccct tttcaccctt
     9121 ggacttccgc gacttcttgt tggcggcctt ctccgcctcc tcccggcgga tacggtccag
     9181 ttcgccggtc agggcggcga tggaggggtt catcttgatg cccttgatga tccagccgcg
     9241 gaagatgtag ccgttctggg tcaggaactc gcgggcgacg acgggctcct cctcaccggg
     9301 gatgacgaag cgcggcacgg ggccgtgccc gtagggggcc agggtgatcg gatcctccag
     9361 ggtgccgtcg ccgttgatct ccaggccctc cacgacggtg cggctgcgca cgaacagcgt
     9421 ggcgccgggc gccagtcgca cgtccttcag ggcggcgggg gtgttgaagg ggtggcgctt
     9481 ggtgccgtcg ccgttctcct ccagggacac gtccaggtag tagtcgcgca gctcgggggc
     9541 gggggccgcg gcctccggct cgtcgtcgcc ctcgtcctcg gagtcctccg gctcgtcgtc
     9601 gtcctccgag tccacgtcat ccgcgtcgac gtcgtcctcc accaggtcgt cgtcctcgtc
     9661 ctgcgcgagg tcctcatcct cgtcgaggtc gtccagatcg acgtcctgct tctcctccag
     9721 ggcctcgtca acgtcgtcgg cgaattcgac acgctcccgc gcggtggtgg gagcaggagc
     9781 aactgtggaa gtagccacgg atttcctttc gcggagcaga cggttcggcc ggagcggtgc
     9841 atggagcctc ggcgaagttt acgcgagaac ccaaatggtc tcacaggcgc acgcgcctaa
     9901 cgcgaggact tcacacgaga tccggctacc actaccagcg cgaagagcaa cgatgcggac
     9961 gccgtgtcta ttcccgagcc cgatcatcta gcctgtgcgc atgaccgacg tggacgccct
    10021 gctgccgctc gtgcgcggcg ccgtcgatgc ccgcctggat gaggtgctgg cccggctgcg
    10081 cgcccagtgg caagactccc ccgccgtaac cgatgagctg ctcgaggcag ccgccacggc
    10141 cctggcgggc gggaagcgaa tgcgggcggt tctgggcgca gtgggattga ccctggcggg
    10201 aggagacgcc gaccccgccg ccgtggcggc cggcccgacc gcggcccggc tgggcgccgc
    10261 cctggagctg taccaggcga gcgcgctcgt acacgacgac gtcatcgacg ccgccgacac
    10321 ccgccgtggc cagccggccg cacaccgtcg ttacgcggcc cgtcaccgtc gggccggctg
    10381 gaccggctcg gccgacgtct acggcgtcag tgccgcgatt ctcctgggag acctgctcat
    10441 gtcggccgcc accgcacaac tgggccaggc gacggccggc tgcgagcgcg gcgcggcacg
    10501 ggccgcccgg gacgccttcg acgccatgac ggcggaggtc gccgtcggcc agttcctgga
    10561 cgtgcaccag gaggtgatgc ccctgccggc cccgacggac cgaccggtgg cggcgggtgc
    10621 cgccatgcgg gaggccgcac tggaggtgat acgccacaag tcggcgcgct actcggtgat
    10681 gtatccgctg caggtggggg cgctgctggc cggcgtggcc ccccatggcg agttgttgac
    10741 cgccctggag gtattcggtg aggagatcgg gatcgccttc cagctgcgcg acgacgtgct
    10801 gggcgtattc ggcgacccgg ccctgaccgg taagccggcc ggtgacgacc tgcgcgaggg
    10861 caaacggacg gtgctggtgg ccctggcctg gcagcgctgc aacaacgcgg gccggaagct
    10921 gttgacccgg gtgctggccg gggacgaggc cgccacggcc gcggacttgg cggcggccgc
    10981 cgcactgatc cgcgactgtg gggccttgaa cgcgcatgag gatgagatcg ccgcccacac
    11041 cgccaccggc ctcgccgcgc tggaggccgc cccgggcgcc ctgccggagc gttcgcggcg
    11101 caccctgttg gggctggcag aaatgctgac cgcccgccgc agctgactgc gggcgcggcg
    11161 gcccctgacg caccggggcg tgcgagcccc gtacactcgg ctacgtgacc aaggatcctc
    11221 tcatcggccg gctggtcgac gctcgctacg agatcgtcga ccgcgtggcc cgtgggggca
    11281 tggccaccat ctaccgggcg catgaccgcc gcctggaccg catggtggcc ctcaagctca
    11341 tgcacccgca cctggcggac tccccggact tcgtggcccg gttccgccgc gaggcccgcg
    11401 cggcggcgcg gttgtccaac ccgggggtcg tggccgtcta cgaccagggc agcctggacg
    11461 gcatcgccta tctggtgatg gaactggtgg agggccccaa tctgcgcgac ctgatcgcct
    11521 ccggtccgtt gaccgtgcgt gaggcgctcg ggctgaccgc ccagatcctg gggccgctgg
    11581 gggcggctca ccgcgccggc ctggtccacc gcgacgtcaa gccggagaac gtgctgctgc
    11641 ccgccgacgg ctcggtcgcc aaggtcgccg acttcgggtt ggcccgcgcc gtcaccgagg
    11701 tcgcccagac caccaccggg aacgtgctgg gcacggtcgc ctacctggcg ccagagttga
    11761 tcaccaccgg ctcctccgcc ccctgcgccg acgtcttctc cgtcggcgtg atcctgtatg
    11821 agctgctcac cggcgtccag cccttcgagg cggacacacc catccagatc gccttccgca
    11881 acgtgcacga ggacattccc gccccctcgc tgcgggtacc cgacctgccc gagagcgtgg
    11941 acgagctggt cgcggcgatg acgcgccgcg atccgcactc ccggctggac gacgccgacg
    12001 ccgccctgga ccgactgcgg cagatcgtct ccaccctgag cgaggcggag ttggccgtca
    12061 agcgcggcgg cgccaccggc tcggtgcgca cccaggaggt gctggccgct aacgccgaag
    12121 cggcccgcac cgcgatgctg gtcaccgacg gcaccgaatc cgatgcggac gccgccgagg
    12181 ccgccgccga cgcggccacc ccgggcgccg ggctgcgcac cgtctccctg cccatcggtt
    12241 ccatcgcccc ggacggggcg gccggcggcc gggacggcac cacgcgcgcc ctggaccgca
    12301 gtcggctgtc ccgcggcgcg gacacgcaga acacgcaacc ggtggcccgc cactccgcgc
    12361 ggcgcccgcg ccgacgcgcc gtgatcgccg ccgcactgct gctggcggcg gccggaagcg
    12421 ggggcgcctg gtacctcacg gccggccccg gccgcaccgt cccggtgccg cagatcgtgg
    12481 ggatgagcgc acaggacgcg caggatgcgg tcgaggcggc cggactggtg tggggcgccc
    12541 ccacccgcgc ctactccgac acggtgcccg cggactcggt gatttcctgc tcccccggcg
    12601 ccgacacccg actgcacccc ggccaggcgg tgacgccggt gatatcccgc ggcattgagc
    12661 agaaggtcgt gcccgacgtc gtcggctcca ctcaggagga cgccaccagc gcgatcgtgg
    12721 acgcgggcct cacgctcggg gcggtgacca agacctactc cgacgacgtc gcctccggca
    12781 tggtgatttc ctgcgagccg cagtcgggca gcacggtgga tcactcctcc gccgtggcga
    12841 tcgtcgtgtc cctggggcgc cagcccgcca cggtcccgga cgtgaccggc atgagcgtgg
    12901 aggatgccac caccacgctg gaggcggccg ggctcacgct cggcacccag tcggaggcct
    12961 actccgacga tgtggcctcg ggaatgatca tctcctccag cccggcctcg ggggcggagg
    13021 gctaccacca cggcgacgcg gtggacgtgg tcgtgtccaa ggggccggag aaggtgagcg
    13081 tgcccgacgt cgtcgggatg agcgagcgcg aggccgtgac cgcgctggag gacgcggggc
    13141 tggacccgca ggtctcccgt gtcatgggcg gcttgttcga cacggttcac tccaccgacc
    13201 cgtcggccgg gcagagcgtg gagaagggct cacaggtgac ggtgaacgtg atctgagccc
    13261 gggccgactc agccgcggag catctccgcc acctcgaagg ccatctccag ggactgctgg
    13321 tggttcagcc gcgggtccac gagcgtctcg tagcggcgcg ccagcccggc ctcgtcaatg
    13381 tgctcgccgc cgccgaggac ctcggtgacg tcgtctccgg tgagctccac gtgaatgccg
    13441 gcgggcacgg tgcccagcgc ccggtgtacc tcgaagaagc cgcgcacctc gtccatgatc
    13501 gtgtcgaagc ggcgggtctt gtagccgttt tcagaggtga tggtgttgcc gtgcatgggg
    13561 tcggtgatcc aggtgaccgg tcggccgtcg gcgcggacga tctccaccag gggcggcagc
    13621 acgtcgcgga tgcggtcggc gcccatgcgg gtgatcaggc tgagccggcc ggggtcccca
    13681 tccgggttga ggtggtcgat cagggacagc agctcatcgc gggtcgtcgt cgggccgatc
    13741 ttgacgccca ccgggttgtg cacgcccgcc agcagtgcga cgtgggcgtc gtcggcaccg
    13801 cgagtgcgct cccccaccca caggaagtgg gcggaggtgt cgtaaaggcg cccactgcgg
    13861 gagtcctcgc gcgtcatggc gtcctcgtac tccagcagga gcgcctcgtg cgcggcgtag
    13921 aagtcgacct ggcgcagggc ttcgaagtcg acgccggcgg cctccatgaa gcgcatggcc
    13981 cggtcgatct cctcggcgaa ggactcgaag cgcttgtagg cggggttcgc ggtgaagccg
    14041 cggttccagg agtggacttc acgcaggtcc gcgtagccgc ccatcgtgaa ggagcggatc
    14101 aggttcaggg tggtgccggc gcgcaggtag gcgtcgacca tgcgctgcgg gtcggggata
    14161 cgggcctcgg cggtgaaggc gtggtcgttg acggagtcgc cgcggtagga gggcagggtg
    14221 acaccgtcgc gggtctccgt gtccgagctg cgcggcttgg cgtactggcc ggccatgcgg
    14281 ccgatcttga ccaccggggt ggaggcgccg taggtgagca ccgccgccat ttgcagaatg
    14341 gtttgcagct tcaggcggat gttgacggcg gtgttgtcgt ggaaggactc ggcgcagtcc
    14401 ccgcccatga gcacgaaggc gcgcccctgg gaggccagca ccatcttctc gcgcaacgag
    14461 tcgacctcgc cggcgaacac cagtggcggc cgggtgcgca ggtcggccgc ggcgtcggcc
    14521 agcgcctgcg ggtccgggta gcggggctgc tgggcggcgt ggtgctggcg ccagccggcc
    14581 gccccgccgg gtacctggag ctcgttcatc atggggtcag cataggcgtg cgggaccgct
    14641 gccgaaccgt cacgccgaaa ggtgggacgc agggcacgcc gtcggccggg ctccccttcg
    14701 gcgtcttgtt gcgcacagcg agcccagaag ggggcgggcg gacgcgttct cccgcgtccg
    14761 cccgccccct ctaactgggt tgtggatgag ccggcggctc aggcctcacc gtccgtggcg
    14821 gcggcgggct cgaggttctg gccgagctcg gccatcaggt cgacgaacca ctgctgggtg
    14881 atgtcgaagg gcttgccgcc ggcaatgcgc tcgaaggcga tggcgccgag ctggtcgccg
    14941 ttctcctcgt cctggccgat gacaccgggc tcgccgcgca gggcgcagtc gacggcgagg
    15001 tcgcacatct gcttgatcag ggccaggtcc tcctcgttgg cggcggcggc acgcgagtag
    15061 tagccggact tctgcaccat gaccttctcg gcgccgatct tgtcggcgaa ctggcgggcg
    15121 aaccactggc cggggttgat ggtgtcgagc ttgacgtggc cgaaggggtc gcgctggacc
    15181 tcttcaccct tggcctccat ctccgcgatg atctcgggga cgccggcgcc ctcggacagg
    15241 aagatgttga cgttgccctg ctcgtccatg atggccttga ggcgctcggc ctcggcggcg
    15301 atgtccagct tggcctccgg cacgaacacg gcgtgcacgt cccagcgctc cttggtcagg
    15361 cccagcgagg gggcccactg gcggtccttg agcagctcgt ggtagcggcg ggcggtctcg
    15421 gcggtgaggt aaccgcagtt gcgacccatg cactcgtgga cgatcagcat gcgcgggttg
    15481 gagcggtgct caccgatgac gttgagggcg aagccggcgc cctgctcggc ggcggtccag
    15541 gcgcccagcg actggcggat cggaacgatg tcgttgtcga tggtcttggg caggccgacg
    15601 acggtcaggt cgtagtcgtg gtcgcgcagg taggcggcca ggtcggcggc ggtagtgttg
    15661 gtgtcgtctc caccgatggt gtgcagcacg tcgacgccgt cctcgcgcag ccgctcggcg
    15721 gcgaaggcga gcgggtccac gccctccttg accaggccgc gctcgacgag gttcttggcg
    15781 ttggtgagct tgacgcggga gttgccgatc ggggagccgc cgtactggcg cagcacgccc
    15841 gcgttcttgc ggccctcctc gtcgatgacg acgtagttgc cggtgagcag gccgtggtag
    15901 ccgtactggt aggcgatgat ctcgacgtcg ggggcgacct cggtgtagcg ctcgatgagg
    15961 tcgcctacgg cggcggacag acagggggcg aagccgcccg cggtgaggag ggcgacgcga
    16021 cggatcgaca tcggaaacct ttcgtaggtg atggggcttg tcgccgccat cctatcggga
    16081 tgccgccccc gcgcgcccgg aatcctcacc ccaacccgga tacccgccga ggtcggtgga
    16141 agttacgtgc cggaccccat cgacaccggt cgggctgcag catggctgag acgctcggcg
    16201 atcacacgcg cgttttcatg tgtgcgtgac gcagcgcgcc gaacgtgact ggatccgctt
    16261 ccgtcggcat gcggcggggc tgagccagcg cgagctcgcg gatcgcaccg gtgtcaccca
    16321 gccactcatt gccgctatcg agtccggcgc gcgtcgtccg tccgctgaca cacgggagcg
    16381 gccgcgaaag gcgttacagg tgcgcccctc agttctgctg cgcgctgggc gcaaagaggc
    16441 catcgcgttg gccggttcgc atggatgcga ggttatcggc gcgttcggct ccgtaaccag
    16501 cggcgaggat cgcccagact cggacatcga cctgctggtc cgttttccac cagatgcgga
    16561 catcctgatc ctgctggaac ttgaggagga gttgtcagat ctactgacgg tgcccgtcga
    16621 cgtgatctcc gtcggcagcg gccctgccac gacgaccgga gcttccctag gtcgtgttgt
    16681 gtaagtcgtt tgtgctggtg gggcgagtgg ggcttacacc gccccggttg gaccgcccac
    16741 gccccgttgg accgcccccg ccccgttgga ccgcccacgc cccgttggac cgcccacgcc
    16801 ccgttggacc gctgtaaccg gcggctacgg cggtccaacc ggggaacagg ggtccaaccg
    16861 gggaacagcg gtccaaccga caggctcaac agccacacac cgccacccaa ccgcgcacct
    16921 ccacccaagc acttacacaa ccggacctag cgcgagcgtg taaggccgcg agcgtgtaag
    16981 gcacggactc accccttctg ggagtcgacc aactcgtcct tgccgagtgt ctccacccgc
    17041 tgagcaccca aatcatccgc tcctgcgcgg atccgctcga ttagcgcggg acggctaagg
    17101 atgtcgagcg tctcctcaac cgactccgga ccatcgacag agatgacgac tgccgcgggg
    17161 cgcccgcgcc gagtgatcgt cacgcggctg cgctcccgct ccacctggct tacgacctcg
    17221 gacaggtggt tcttcacgtc gcgcagcggc atgaaggcgt cgaccgacat agcaacaatt
    17281 gttgccacac cggcggtctg cgtgccgcac agacacttga cgaagttata catacagggt
    17341 tgcctgtaag catgcgtcgc accgccgccg aggccgccga gacccgtaaa gccatcatcc
    17401 actccgcctt gcaccgcttc gcacaggacg gctgggaggg ctgctcgctc gtcgaggtgg
    17461 cgcgcggcgc aaacgtgact cgcggcgccg tttaccacca cttcaccggc aagcgagagc
    17521 tgctggacgc cgtcctggcc gaacaatggc acagccgggg tgaggcgctc ttggccgtgc
    17581 tagacacctc agcaccgccg gaggcgcggc tcacgacgtt cctggcggac tacctgcgca
    17641 ggctccgtga ggacaccgac ttccgcgagc tcgccgtcgt cacggtcctt gtagcgtccc
    17701 aagcaccggc ggtcaagtcc ggactggagc agaaaacggc gtccctcgca cagtggtcgg
    17761 agcagatcgt ccggctcctg gccacctgcg agccgcggct gcgcgttccg cttgacatcg
    17821 cccgcttcac catcacgaca ttcctgcacg gcgccacgct caccgccgcg ctcatgccag
    17881 aagacctgcc cgaaccaggg cgctgcgaaa cgacggctcg tgccctcgtc gccggcctga
    17941 tcaacatcga atcgccttga ccccagagaa agaccggaca tgcaaccaac accctccgat
    18001 gccacaacca gcccgcgcat ggccgtggtg gtcgcctgcg tcgctctgtt caccgacatg
    18061 ctcgtctacg ggattctcat ccccgtactc cccctgctcc ccgccatggc cgaggccggt
    18121 ccctcggcaa ccgggctgct cttcgccgcc tatgcggccg cactggtgat ggtcactcct
    18181 atcgccgggc gagttgtgga caaacgcggt tctcgtgggc cactgctcgc tgcgttggtg
    18241 ggtctggcat gcgcgtgtct gctgttcacc atcggtggtc cttactggtt gcttctgacg
    18301 gcccgcacgc tccagggagc tgccgccgga ttgagttggg tggccggact gtcactgatc
    18361 gccgcgaccg tgccactgca gcgacgcgcg acctatctcg ggctggcgat gagtatggtt
    18421 tcggtcggcg cgttggcggg acctcccctg gcgggctggt tggccgggct cggcggacac
    18481 tccgctccct ttcttctcgc ggccgtgctg ctcatgatcg acggcgcgct acgactcgcg
    18541 ttcgtccgac caacctcacc gcccagcgac gaccccgcta ccgccttgga tgtgttgcgc
    18601 acgcccggat gttggccggt cgtcgcgctg attctcatag gtgccgccgt aacctcatgc
    18661 attgagccgg tgctccctat gcaactggct cgggagttcg gcgtaggttc tgcgggcatc
    18721 ggcatgctgt tcgcgctgct tacgcttgtc gccgcatgtc tgaatccact ggtcggtgct
    18781 tgcctgccgc gcgtgtcgct aagagcattg acgctggtgg gcgccgcaag cgcggccgcg
    18841 ggtttgttgc tagtcggggt tggaccgaat ctcccggtaa tcaccgccgg gcttgtgtgc
    18901 ctaggctccg caatcgcact cctggtggca ccggcaagtg cactaatagg cgttcaggga
    18961 gccatggcca cacctcccgc tatcggcggc gcctactccc tctacaacct ggcttacgcg
    19021 ggcggcctgg tcctgggacc tgcactcagt ggtccgctca ccgagcacct cggcttcacg
    19081 catgcctgct tgacgctggc ggggttccta gcgctcaccg ttcccacatt catccggttg
    19141 ccgcgcaagt acgcggccgc gaccgccgaa agtgtccaga ttcgggacag acggggtcag
    19201 catccctgat tgcgtccgtt gaaatcgcat gatttcaatg cactggcaca ctggcacggc
    19261 gacgacagcc tcgtttgtcc cgaatatgga ctgacggtgt gcccatgctc aatcatcatc
    19321 ggggcgcggc gcgttttctg ccgcatcgtc ctcggacgcc tctgtcccct cgtcgtcttc
    19381 cgccttgtct ggctccgccg gcggctcggg gacctcgacg tcgggggcgg gacgaccgcc
    19441 gggtgcctcg acgggggcgg cggccggccg cttggcggcc aactcctcca gcatctcgtc
    19501 gacgacctcc gcggccgtct tcttctccgc gtccatcgcc ttcttcacgt ccgcggcgta
    19561 caggtccacg tactcctgac cggacaggga catcagcgca tacatgatct cgtcggtgat
    19621 ggagcgcagc acgaagcggt cgttctccag accctggtag cgggagaagt ccagcggctc
    19681 accgatcacg atccccaccc ggtgccgggt ggagggaacc acctggccga tgggctgggc
    19741 gaggttggaa ccgatcatgg cgaccgggat caccggcgcc ccggtggcca gggcgacgcg
    19801 cgccaccccg gtcttgccgc ggtacaagcg cccgtcgggg ctacgcgtgc cctcgggata
    19861 gatgccgaac aactcgcccg agcgcagtcg atcgatcccg gcctgcagag ccgccatgga
    19921 cgctttgccc cccgagcggt ccaccgggat ggtgccgacg gcggtcatga agttcttcac
    19981 cgcccagccc ttgatgccct tgccggtgaa gtagtcggac ttgccaatga aggcgacctc
    20041 gcggtccatc agcaacggca gaaagaatga gtcgatgacc gccaggtggt tggaggccag
    20101 gatggcgggg ccctcggcgg ggatgttctc ctcaccgcga atccagggct ggtagagcat
    20161 ctccatggcc gggccgacgg cggccttgat acctcggtaa cccactgtgg gacctcctgt
    20221 gtgcatccgc ggtcgggaac tggccggccg cccgggtaca cgcgccgggc gtgtccgcgg
    20281 ccggatcggc tgctgatcaa gtctagcctc gcggtgtggt ccaacacgtg ctctcgcctc
    20341 cgccgtccgt cggcgccgtc ttcggccgtg ggcgacgcga gccggcacgg acgccgtcgt
    20401 caccgtccca gccggtccag gcggccttcg cggacatggg aacggcgctg cgtgaggtga
    20461 ccttcgtcgt cgtcgatctg gagaccaccg gaggcggccc gggcgcgcac gccatcaccg
    20521 agatcggtgc cgtgaaggta cgcggcgggg tggtcgattc ggaattctcc acgctcgtaa
    20581 atccgggcac cgccattccc gcccagataa cggtcctgac cggcatcacc aacgccatgg
    20641 tcgccgacgc ccctccggta gcccaggcgg tggccgcctt cctgcagtgg gcgcacctgg
    20701 ccgacccgac gacggtggcg gtcgcccaca acgcccgctt cgacctcggc cacctgcgcg
    20761 gggcggcccg ggccctcgac ctggattggc gtgagccggt cgtactggac acgctggcac
    20821 tggcccgccg ggcctgggac cgcacccagg tgcccaacca caagctgggc acgctcgcca
    20881 ccttcgtggg ctccccgacg acgcccaccc accgcgcgct ggacgacgcc cgtgccacgg
    20941 tggacgtgct gcacgccgcc ctggaacgcc tcggtcccca gggcgtcacc cacctggagg
    21001 acctggccac cgccaccgac cccgtgcccg catcccggcg ggtcaagagc cggctcgccg
    21061 acgacctgcc cgccgcgccc ggcgtctatc agttcctctc ccccgccggg caggtgctgt
    21121 acgtgggcag cgccgtgaac ctgcac
//
