LOCUS       NZ_CP023704            26379 bp    DNA     circular CON 27-APR-2024
DEFINITION  Caldibacillus thermoamylovorans strain SSBM chromosome, complete
            genome.
ACCESSION   NZ_CP023704
VERSION     NZ_CP023704.1
KEYWORDS    RefSeq.
SOURCE      Caldibacillus thermoamylovorans
  ORGANISM  Caldibacillus thermoamylovorans
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Caldibacillus.
REFERENCE   1  (bases 1 to 4016170)
  AUTHORS   Cai,L., Zheng,S.W., Shen,Y.J., Zheng,G.D., Liu,H.T. and Wu,Z.Y.
  TITLE     Complete genome sequence provides insights into the
            biodrying-related microbial function of Bacillus thermoamylovorans
            isolated from sewage sludge biodrying material
  JOURNAL   Bioresour Technol 260, 141-149 (2018)
   PUBMED   29625286
REFERENCE   2  (bases 1 to 4016170)
  AUTHORS   Cai,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-SEP-2017) Faculty of Architectural, Civil Engineering
            and Enivironment, Ningbo University, No. 818, Fenghua, Ningbo,
            Zhejiang 315211, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. January-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 125.05x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003096215.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 02:24:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,916
            CDSs (total)                      :: 3,812
            Genes (coding)                    :: 3,697
            CDSs (with protein)               :: 3,697
            Genes (RNA)                       :: 104
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 115
            CDSs (without protein)            :: 115
            Pseudo Genes (ambiguous residues) :: 0 of 115
            Pseudo Genes (frameshifted)       :: 35 of 115
            Pseudo Genes (incomplete)         :: 75 of 115
            Pseudo Genes (internal stop)      :: 20 of 115
            Pseudo Genes (multiple problems)  :: 13 of 115
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:21:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3805143
            Orig. end                         :: 3831522
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023704.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26379
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26379
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26379
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16379](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16379)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    306..323
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.24"
                     /tool="antismash"
     gene            complement(531..1817)
                     /locus_tag="CQJ30_RS18255"
                     /old_locus_tag="CQJ30_18180"
     CDS             complement(531..1817)
                     /EC_number="2.5.1.7"
                     /GO_function="GO:0008760 - UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019277 - UDP-N-acetylgalactosamine
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015865335.1"
                     /locus_tag="CQJ30_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18180"
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="WP_108898948.1"
                     /transl_table=11
                     /translation="MDKIKVIGGKTLKGSVKISGAKNSAVALIPASILAESPVTIEGLP
                     EISDVEILKKLLEEIGGVVHLEDQDITIDPSMMTSMPLPNGKVKKLRASYYLMGAMLGR
                     FKKAVIGLPGGCHLGPRPIDQHIKGFEALGAKVTNEQGAIYLRADELKGARIYLDVVSV
                     GATINIMLAAVRAKGKTVIENAAKEPEIIDVATLLTNMGAKIKGAGTDIIRIEGVDHLH
                     GCHHTIIPDRIEAGTYMILASAMGRGVLVDNVIPYHLESLIAKLREMGVSVETSDDQVY
                     ISKAKKLVAADIKTLVYPGFPTDLQQPMTALLTNAEGTSVVTDTIYSARFKHIDELRRM
                     NANIKVEGRSAIITGPVQLNGAKVKATDLRAGASLLIAGLMARGLTEITGVEHIDRGYS
                     HVVEKLQGLGANVWRETLTEEEMEQVKNS"
     misc_feature    complement(1866..1877)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.22"
                     /tool="antismash"
     gene            complement(2175..3032)
                     /locus_tag="CQJ30_RS18260"
                     /old_locus_tag="CQJ30_18185"
     CDS             complement(2175..3032)
                     /EC_number="4.1.2.13"
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391593.1"
                     /locus_tag="CQJ30_RS18260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18185"
                     /product="class II fructose-bisphosphate aldolase"
                     /protein_id="WP_034773236.1"
                     /transl_table=11
                     /translation="MPLVSMTEMLEKAKAGKYAVGQFNINNLEYTQAILQAAEEEKSPV
                     ILGVSEGAARYMGGFKLVTAMVKALMEEYKITVPVAIHLDHGSSFESCARAIHAGFTSV
                     MIDASHHPFEENIQITSKVVELAHLHGISVEAELGTVGGQEDDVVGEGIIYADPNECVE
                     LVNRTGIDALAPALGSVHGPYHGEPNLGFKEMEEIAKLTGKPLVLHGGTGIPTHDIQKA
                     ISLGTAKINVNTENQIASAKTVREVLAKNADLYDPRKYLGPARETIKDTVKGKMKEFGS
                     VGKA"
     gene            complement(3207..3590)
                     /locus_tag="CQJ30_RS18265"
                     /old_locus_tag="CQJ30_18190"
     CDS             complement(3207..3590)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013146624.1"
                     /locus_tag="CQJ30_RS18265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18190"
                     /product="response regulator"
                     /protein_id="WP_108899161.1"
                     /transl_table=11
                     /translation="MDNGKILIVDDQFGIRLLLNEVFKKEGYQTYQAENGQIALKLAGM
                     HLPDLVVLDIKIPGMDGIEILKRMKEIDPSIHVIIMTAYGDLKMIHKAKELGALTHIAK
                     PFDIEELAKTVKEILSDKILEKI"
     gene            complement(4096..4542)
                     /locus_tag="CQJ30_RS18270"
                     /old_locus_tag="CQJ30_18195"
     CDS             complement(4096..4542)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008881434.1"
                     /locus_tag="CQJ30_RS18270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18195"
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_108898949.1"
                     /transl_table=11
                     /translation="MKNSILLMAVAGVILLGGCSLLKDLKQTASENMEIDKTLPKYKLN
                     MENFKEISYEGKTYVIQEAEVTKEDLDEPIGKVTETITINENNEILSKKELKKVEVVPK
                     EEDEKRTHLNYGWVYSIKDVSPDEEVAVVINNQFRVAKIKLVDE"
     gene            complement(4578..5366)
                     /locus_tag="CQJ30_RS18275"
                     /old_locus_tag="CQJ30_18200"
     CDS             complement(4578..5366)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004888811.1"
                     /locus_tag="CQJ30_RS18275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18200"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_108898950.1"
                     /transl_table=11
                     /translation="MSFLHVLSSEWLKTRRTAIRLIVFVTPIIYPIFMLWYFSRYKDPS
                     FWQVKIYGGFFEVLSVSLPIVISLLTGLMAYQEEKSGSFMNVLTGPVSRVKFYFGKLSL
                     LIFAAIADIFLATFLMLLGMRYILNVENVHYDLFLQGAFLSLVGSLILFSLHLLISFAF
                     GMGASIAIGGGGFLVSAIIGATVVGDHIWPYIPWAWTVRLSQVPMLLMLKVKHAFGMEL
                     SDLYVQELMKGIIPASICFILVTLLGFVWFNRWEGGKSYE"
     gene            complement(5368..6114)
                     /locus_tag="CQJ30_RS18280"
                     /old_locus_tag="CQJ30_18205"
     CDS             complement(5368..6114)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003253344.1"
                     /locus_tag="CQJ30_RS18280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18205"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_108898951.1"
                     /transl_table=11
                     /translation="MLNMIQSERLKYKRTFAKKLVYIAPFFFVLYAIITMPTIHSKYNY
                     FEYTVFNWWPLLFLPLGTALIASLAAMREKKSGNYRALRCHDISIPRMWFSKIIVIAYY
                     TLLSSIELMILLILLKLFLPNSISSAAVVVMASLTIWITSLAYIPIGLFFAERFGTVIS
                     IIVSLIGIVLGVVMAPESYWMFIPWSWGMRLMSPIVGVHPNGVPLKEGNPLLDPSVIPI
                     GILASIVIFALLSLVTAFWFSRREVN"
     gene            complement(6130..6822)
                     /locus_tag="CQJ30_RS18285"
                     /old_locus_tag="CQJ30_18210"
     CDS             complement(6130..6822)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004888813.1"
                     /locus_tag="CQJ30_RS18285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18210"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_108898952.1"
                     /transl_table=11
                     /translation="MSAYFLETKQLTKAFGKQLAVDNVSIRVKENTIYGLLGPNGAGKS
                     TILKMLTGLLRPTKGEILFNGHPWSRKDLKEIGALIESPALYGNLTAYENLLVHAKLLN
                     LPDSRIKEVLKIVDLENTGKKKASQFSFGMKQRLGIAKALLNDPKLLILDEPTNGLDPL
                     GIQELRKLIRSFPKQGMTVILSSHILPEVKQLADHIGIIQNGKLKYQGEIEEDQDLEKF
                     FIDVVNGL"
     misc_feature    6998..7014
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.53"
                     /tool="antismash"
     misc_feature    complement(7010..7024)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.55"
                     /tool="antismash"
     misc_feature    7011..7025
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.25"
                     /tool="antismash"
     gene            complement(7736..9187)
                     /locus_tag="CQJ30_RS18290"
                     /old_locus_tag="CQJ30_18215"
     CDS             complement(7736..9187)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013401756.1"
                     /locus_tag="CQJ30_RS18290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18215"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_108898953.1"
                     /transl_table=11
                     /translation="MKKDKTIKRDFYLLVVKVFLSTILSSAVTYLCLIYFIFMFAENNT
                     IKPTDYFVKYLDVIEKKIEESAPDILNGELINLDQYSEKIEGEVLDINGNHLYGDQDVA
                     GYKVKVGEVINREIVKGSYVYRFIPIKHDNAIQAVYVLKAPFGFIINNQDRLGIVFIYV
                     VLLISPLIFFVIYLIFYTSKLYKSLFNNIKVLLQAADKISNGDFDFKISGLKRKEFMRI
                     QDSFNTMIDALKEMIESISKIDDERKIMVSSIAHDIRTPLTVIQGQMDLINDLKDIEKF
                     DITPHLDIIRKNCSKMSMLTDNLSLLYKVENVDFLLNIKKVDLGKMLHEKKQEILTMAH
                     YQRSVQILFDVCLSKQYYLLDEAMLMRVLDNILYNSLRFTKSGKIKLEVHDESDGHSSK
                     IYFKCSDTGTGFKEKDTSQLFKAFYQDVQYKDHVGLGLYISKKIVNNFDGQIQAYNNEN
                     GGATVEFYIKEQSIICYQLSEKSSF"
     gene            complement(9174..9872)
                     /locus_tag="CQJ30_RS18295"
                     /old_locus_tag="CQJ30_18220"
     CDS             complement(9174..9872)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003253340.1"
                     /locus_tag="CQJ30_RS18295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18220"
                     /product="response regulator transcription factor"
                     /protein_id="WP_034773250.1"
                     /transl_table=11
                     /translation="MHLKKILVVDDNEDICLTIKQYLELYHYTVEYVHNGTEALQIINN
                     DFDLIILDIMMEGLDGMELCGIIRDKVNCPIIFVSAKTLEEDKVQALSIGGDDYMTKPF
                     SLKELKARIDSHLRREERIRSNDRHLLSSKNITIDLLANEVFCKGVQLHLTKKEYEIIK
                     LLMLNKNMVFSKDRIFERVWGLDSESQLETVTESIKNIRKKIRSLDKENSYIKTLYGLG
                     YKWDVTNEKG"
     gene            complement(10001..11308)
                     /locus_tag="CQJ30_RS18300"
                     /old_locus_tag="CQJ30_18225"
     CDS             complement(10001..11308)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011886697.1"
                     /locus_tag="CQJ30_RS18300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18225"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_041845004.1"
                     /sec_met_domain="LANC_like (E-value: 1.3e-82, bitscore:
                     275.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVSVKEPVCNIARKLSDYENMLQIVNHPKNFLQIGNKRINPFHE
                     LSLSHGLPALCALYGEMSEHYPDEDWDALGHQYMKRIGEQINQNGFSSLSMFTGLTGVA
                     LAAVCLSKEGKRYQKFIANINIVIEEKMEEIITNLKQKSYPNMDDYDAISGVAGIAGYC
                     LLFPEEMKKTITLILKYIIDLSQDKEMEDLRIPGWYILPEHAFSEREKRNWPSGFINIG
                     LSHGIPALLIILCNAKKLNIYTDGLDECIQKIADFLIKFQIKDEIGVYWGTHVSLEEYY
                     QGTVLNKNTRDAWCYGTPGVAYSLLIAGKTLNNQTYIDCAIRGMELASKRLYDIFSPSF
                     CHGLAGVAYICNRFYEETNISDFRQTALTLANDIMKYYNKEYPFGFKNIEGSEKGKEYY
                     DYVGLIDGTAGILLTLLAIQNGKKTPWDSAFLLSKV"
     gene            complement(11277..13109)
                     /locus_tag="CQJ30_RS18305"
                     /old_locus_tag="CQJ30_18230"
     CDS             complement(11277..13109)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011229812.1"
                     /locus_tag="CQJ30_RS18305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18230"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_041845003.1"
                     /transl_table=11
                     /translation="MDIREYDDDRVTVKDIVKSVKMVPKTLMLIKNVDKKSFYIIIFLS
                     LLMGIAPIITLFGSQNLLNAIGFQNIRIIISALIFYIFANLFSEIISGFTEYYQNKFQT
                     LINYKLNLKVMDKCTKLSLRHFEDAEVYDMLQRVQNETPYKPFEVFLSILGTISAVVTL
                     FSSVMILINWKPWVLIILIFIPVIFSLYFFKIGQREFNVSWLRAPEKRKSWYLSYLMTR
                     DNTFKEVKLYNLAGYILKQFKEINKKFVGQDIKLFKRRTIFTFIFELVEQICINTVLVI
                     VILSALAGEILVGHVVGLIQALNLISNNSRIILNTIHSLYKNNLYIIQLFEFLALDEEV
                     LNKEGRLALGVDKIENIKIRNLTFSYPTNSKVVLKNINLDIHKGERIAIVGANGSGKST
                     LIKLLLKLYDHDEDSIFYNDVSIHDLDTAQLRKNIAVLFQDFVKYELKLRENVGFGDIT
                     RIEQDKELKQAMDRAQLNFIKDLDTQLGLWFVDGVQLSGGQWQKVAIARAFFRNASVYI
                     LDEPSSALDPISEKEVIDMFLDMTKDKIGIFISHRLSTAKLADKIVVMNDGEIIGIGTH
                     HELLATNDLYRRMYELESMQNEVEYERFSERASL"
     gene            complement(13239..16379)
                     /locus_tag="CQJ30_RS18310"
                     /old_locus_tag="CQJ30_18235"
     CDS             complement(13239..16379)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014194788.1"
                     /locus_tag="CQJ30_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18235"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_108898954.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.7e-149,
                     bitscore: 494.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.1e-16,
                     bitscore: 57.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-32, bitscore:
                     111.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEQIFKDIDTFMIRTPVLSMNIYLKFFDQKLTEEEMKEHLLEIC
                     NDPFFRQSILAASKSLYNKMLDFCNGKKIKKYDYFLKAIYKYLIRMSTRPTPFGLFAGI
                     DFGEFTEETTLIKFGANKYKKFARPDLEWIMKIVKKLEQEQYGQLWFKINDSIFFKGER
                     AYLLHSTIKDTDKKVNEISVRITSPFEMTYQLAGRLIPFQKLKNELMTRFSNATEEKIE
                     HFLKQLIKNEFLISNLRPPLTVMDQLDYLIKELKKSNLEEWVNALTNIQEEIRKYTMTP
                     FGEGEKIYKDLHRKMTQLVKSKYVLQVDAKLNLQEKKLNKKVIKDLNKLMRMLLPFSMT
                     YQQTDSPFSRYKQEFIEKYGVDREVPLLEMLDQDLGIGAPVDYENPKNAGINAGMVQPS
                     TDEQLRDYFLQKYVEAVKDKKSIMITDDEIKELGLDDYNYNSIPDSLDMNIIVKCNSDQ
                     DIADNRFTYYLGPNLGATHAGKSFGRFAYMMDGEEKLFETLNEEILNLNDDSDEYVTCE
                     IVYMPNETRNANVTRNIHHSEYELALFTNNSRDEEHRLSLNDILIGIENDLFYAKSKTL
                     NKKLLITINNMLNTRTAPNPIRFLYDLSLDGKKIWYNFPWDIIFSEYSYIPKIEYKNFT
                     ISPEKWVLNKIIKTNSKMDFADFEERFKKFCLEYHVPKFVYLTFADNRVLLNSEDEHCI
                     RILHHQFNNRYSNIILSSYEDGGLNLVKDHADEEYICEMVIPLVKVKQEVNEHYVKPKK
                     SHQIPSLSDERVKLPFEDWIYLKLYGVNSNMDDLIAFYISEYCREKWAKGEIEKYFFMR
                     YADPEQHIRLRLNASEGKLLQMYPDIKQWLRTLMEKGLLSRFSIDTYEKEIERYGGREL
                     IHFAETLFCTDSIVTEDILKLKRLKTINFSDEVIGMVSIIHYMEQFGLEYESQLDFMQQ
                     QVNKQDYREDFKQNRSYYMKVCNTDNDWKGLRETEEGTLLLNVLNQRNDSIKAYAKKIR
                     EGLEASSELSILDSVIHLHCNRLFGIDREFEKKVRTLVGHTLYASKYIKLHEVVLEK"
     aSDomain        complement(15657..15920)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CQJ30_RS18310_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.30E-18"
                     /identifier="RREFam001.1"
                     /label="CQJ30_RS18310"
                     /locus_tag="CQJ30_RS18310"
                     /protein_end="241"
                     /protein_start="153"
                     /score="57.7"
                     /tool="antismash"
                     /translation="NDSIFFKGERAYLLHSTIKDTDKKVNEISVRITSPFEMTYQLAGR
                     LIPFQKLKNELMTRFSNATEEKIEHFLKQLIKNEFLISNLRPP"
     misc_feature    16805..16816
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            complement(16927..17133)
                     /locus_tag="CQJ30_RS18315"
                     /old_locus_tag="CQJ30_18240"
     CDS             complement(16927..17133)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="CQJ30_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18240"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_311315771.1"
                     /sec_met_domain="TIGR03731 (E-value: 1.5e-19, bitscore:
                     67.6, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 1.3e-05, bitscore:
                     22.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDTKMERRCNGMAKFDDFDLDIVVKKQDTTVQPNVTSKSLCTPG
                     CITGILMCLTQNSCVSCNSCIKC"
     CDS_motif       complement(17029..17133)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MIDTKMERRCNGMAKFDDFDLDIVVKKQDTTVQPN"
                     /locus_tag="CQJ30_RS18315_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16927..17028)
                     /prepeptide="core"
                     /locus_tag="CQJ30_RS18315_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="17.50"
                     /molecular_weight="3249.9"
                     /monoisotopic_mass="3247.5"
                     /core_sequence="VTSKSLCTPGCITGILMCLTQNSCVSCNSCIKC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIDTKMERRCNGMAKFDDFDLDIVVKKQDTTVQPN"
                     /leader_location="[17028:17133](-)"
                     /alternative_weights="3268.0"
                     /alternative_weights="3286.0"
     gene            17764..18297
                     /locus_tag="CQJ30_RS18320"
                     /old_locus_tag="CQJ30_18245"
     CDS             17764..18297
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022200.4"
                     /locus_tag="CQJ30_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18245"
                     /product="DUF2529 family protein"
                     /protein_id="WP_034773253.1"
                     /transl_table=11
                     /translation="MSKIFTTQLIGRLQKISEQELDIEDAARLLAQALVGEGSIYIFGE
                     NDLRSVFLEAKYGQEPLQRVQEWTGDTFEQLSTADRVLIFSRNIANEQVVVLAKKLRSL
                     QVPFVVVGSISVKDVNPVENLADVCINLHIDTGLVPDERGGRTMYPHAIAALYVYHSLK
                     FRIDEIMEDYAFGS"
     gene            complement(18512..20119)
                     /locus_tag="CQJ30_RS18325"
                     /old_locus_tag="CQJ30_18250"
     CDS             complement(18512..20119)
                     /EC_number="6.3.4.2"
                     /GO_function="GO:0003883 - CTP synthase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006221 - pyrimidine nucleotide
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006241 - CTP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016765932.1"
                     /locus_tag="CQJ30_RS18325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18250"
                     /product="CTP synthase"
                     /protein_id="WP_034773256.1"
                     /transl_table=11
                     /translation="MTKYVFVTGGVVSSLGKGIVAASLGRLLKNRGLKVTIQKFDPYIN
                     VDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSRVIKKERR
                     GDYLGATVQVIPHITNEIKDQVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQLKS
                     DLGSSNVMYIHCTLVPYIKAAGEMKTKPTQHSVKELRSLGIQPNVIVVRTEMPISQEMK
                     DKIALFCDIDSQAVIESRDADTLYEIPLSMQSQGLDTIVCNYLKIVSHEPNMSEWEALV
                     NKVRNLSKTVKIALVGKYVELQDAYISVVESLKHAGYVFDSDIDIHWINAEHVTEENVA
                     ELLGDADGILVPGGFGDRGIEGKITAIQYARENKVPFLGICLGMQLASIEFARHVVRLN
                     GAHSSEINPDTKHPIIALLPEQEDVEDMGGTLRLGLYPCKIVEGTKAFNAYEDELIYER
                     HRHRYEFNNQYRQIMEEKGFVFSGVSPDGRLVEIIELKDHPWFVASQFHPEFKSRPTKP
                     HPLFREFIRSSLNNREGK"
     gene            complement(20316..20900)
                     /gene="rpoE"
                     /locus_tag="CQJ30_RS18330"
                     /old_locus_tag="CQJ30_18255"
     CDS             complement(20316..20900)
                     /EC_number="2.7.7.6"
                     /GO_function="GO:0003899 - DNA-directed 5'-3' RNA
                     polymerase activity [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="rpoE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019153994.1"
                     /locus_tag="CQJ30_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18255"
                     /product="DNA-directed RNA polymerase subunit delta"
                     /protein_id="WP_108898955.1"
                     /transl_table=11
                     /translation="MSLENLTQEQLQEMSLIEIAYELLYDRKQPMHLNDLVDEVAKLLG
                     ATKEEVQANIAQFYTDLNIDGRFLNVGGNIWGYKGWYPVEQYEDDFVPTVRSKKKKAKV
                     DEVEDDFEELEEDLVEYEEDLDEFIDEDEDEDEFIEEDDLEDIDDVFEDDEDIVEEEDE
                     ELIIDEEFEEELDDEEDIDEDEYIDEEDEEL"
     gene            complement(21556..24834)
                     /gene="icmF"
                     /locus_tag="CQJ30_RS18335"
                     /old_locus_tag="CQJ30_18260"
     CDS             complement(21556..24834)
                     /EC_number="3.6.5.-"
                     /EC_number="5.4.99.13"
                     /GO_function="GO:0004494 - methylmalonyl-CoA mutase
                     activity [Evidence IEA]"
                     /GO_function="GO:0047727 - isobutyryl-CoA mutase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006637 - acyl-CoA metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="icmF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011888413.1"
                     /locus_tag="CQJ30_RS18335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18260"
                     /product="fused isobutyryl-CoA mutase/GTPase IcmF"
                     /protein_id="WP_108898956.1"
                     /transl_table=11
                     /translation="METKVYQAKHPIRFVTASSLFDGHDATINIMRRILQASGAEVIHL
                     GHNRSVEEIVNAAIQEDVQGIAVTSYQGGHMEFFKYMYDLLHEKGAGQIRIFGGGGGVI
                     LPKEIKELHEYGIAHIFSPEDGRVLGLQGMINLMLEQCDFPTINEEVANQVVNLQNQNQ
                     YAIAKMITLAEYLSDKRIATNVGELAPGLETILEKVKEAKKAVPVLGITGTGGAGKSSL
                     IDELVLRFLNEFPEKKLAILSVDPTKQKTGGALLGDRIRMNAIFSPRVFMRSLATRDSK
                     SELSLAIRDALAITKASGFDFVIVETSGIGQGDAEIRAISDVALYVMTSEFGAPSQLEK
                     IDMIDYADLIAINKFEKTGSEDARRQVQKQYQRSHELFHEAPEKMPVYGTIASQFNDPG
                     TNALFAAIIEKFNEVLHLGWSTTYSKKEVVEKHDIIIPNSRRYYLREIADSVRNYHKRV
                     EEQVEYARKLFQIEGTIELTKGNETEGALIDSLEAWKNKMADKLNDTSKKIIENWDQTK
                     ETYAKDRLVTIVRDKEITTELRTKSLSGLWIPKVALPKYKDYGEILRWVYKENVPGAFP
                     FTAGVFPFKRKEEDPKRQFAGEGTPERTNRRFHYLSKDDPAKRLSTAFDSVTLYGEDPD
                     YRPDIYGKVGESGVSVCTLDDMKKLYQGFDLCHPLTSVSMTINGPAPIILAMFMNTAIE
                     QQVELKEKELERPLTEEEYEKVKAYTLSTVRGTVQADILKEDQGQNTCIFSTEFALRMM
                     GDIQQYFIDHHIRNYYSVSISGYHIAEAGANPITQLAFTLANGFTYVEYYLSRGMHIDD
                     FAPNLSFFFSNGLDPEYSVIGRVARRIWAIVMKEKYGANERSQKLKYHVQTSGRSLHAQ
                     EIDFNDIRTTLQALMAIYDNCNSLHTNAYDEAITTPTEESVRRAMAIQMIITKEYGLAK
                     NENPLQGSFIIEELTDLVEEAVLQEFERLNDRGGVLGAMESQYQRGKIQDESLYYETKK
                     HSGELPIIGVNTYLNPNPPKEEEINNIQVARASKEEKETQIKNLMKFKERNQDKVEDAL
                     RKLKQVALSGGNIFEELMETVKVASLGQITNALYEVGGQYRRNV"
     gene            complement(24983..25645)
                     /locus_tag="CQJ30_RS18340"
                     /old_locus_tag="CQJ30_18265"
     CDS             complement(24983..25645)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006320993.1"
                     /locus_tag="CQJ30_RS18340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CQJ30_18265"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_244910462.1"
                     /transl_table=11
                     /translation="MAEKQKVYASVKDERLINIRREQMVKGAISLFKEKGFHRTTTREI
                     ARKAGFSIGTLYEYIRSKEDILYLVCDQIYDEVQSKIQDALDLKKVTIETIREGITSYF
                     LVIDEMQDEVLVLYQEAKSLTKESLPYVLKKEMQMVAMFEQLIKLFSENYGLLLKDKEI
                     KLLAHNIFVHGQMWSFRRWALQKIYTLDEYTNMQVELFIQGVQTFSGKKRDHPFKPA"
     misc_feature    complement(25888..25902)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 16.46"
                     /tool="antismash"
ORIGIN
        1 tttccccctc gccaatgact acggttcctt tcatagggac tgtgtttaaa acttgtcgca
       61 ttgcttgagt tgcagcatca tccgcttcat ttttctttcc ccgtcccatc catctggctg
      121 atgctaatgc ggcggcttcc gtcactcgaa ctaattccat tgacaaactt ctttccatcc
      181 ggtaatcccc ctgaaaaact attttttaac gaataacata gatccaatat attataacac
      241 attttttatt ttgtaggaca caattgaaac aaaataatgg aaaagattgt tatgtctgtc
      301 agcgaaggtt aataaaatgt taaaaaaacc gtgtaagcgg atttttgacg cacactatct
      361 tacggattga ggttaaagaa aagtcgcttg attggacggg tcatgatgtc aagcgactgc
      421 tgagtgaagg gagaaccggg attcaatcga ccttatttat gaattttttg agaggcatgt
      481 ggtcagacat tttttcatat gcctcggtca acccctagct atgacaaaca tcaggagttt
      541 ttcacctgct ccatttcttc ttccgtcagt gtttccctcc aaacgttggc ccctaaacct
      601 tgaagctttt cgacaacatg actgtatccg cgatcaatat gttcgacacc ggttatttcc
      661 gttaaccccc gtgccattaa accggctatt aaaagtgatg caccggcacg taaatcagtt
      721 gcttttactt tcgctccgtt taattggacg ggaccggtaa taatggctga tctgccctcc
      781 actttaatat ttgcattcat tcttcttaat tcgtcaatat gtttgaatcg ggcagaatag
      841 atcgtatctg tcaccacact agttccttcc gcattagtta gtaatgctgt catcggctgc
      901 tgaagatcgg taggaaatcc gggatatacc aatgtcttta tatcagcggc aacgagcttt
      961 ttcgcctttg agatatagac ttgatcatct gatgtttcaa cagacacacc catttctctt
     1021 aattttgcaa tgagcgactc cagatggtat ggaataacat tgtcgacaag aactcctcta
     1081 cccattgccg aggctaaaat catatatgta cccgcctcaa tacgatcggg aatgatcgta
     1141 tggtggcatc cgtgtaaatg gtctactcct tcaatccgga taatatcggt accggcacct
     1201 ttaatttttg cccccatatt ggttaacaat gtagcaacat caataatttc cggttctttt
     1261 gcagcatttt caattactgt ctttcctttt gcccgaactg ctgccaacat aatattgatc
     1321 gtcgccccga cactgactac atcaagataa atgcgtgctc ctttcaattc atcggcacgt
     1381 aaatagatgg cgccctgttc attcgttact tttgcaccaa gcgcttcgaa gcctttaata
     1441 tgttgatcaa ttggacgggg acctaaatga cagccgcccg gcaaaccaat gacagctttt
     1501 ttgaaacgtc cgagcatggc acccattaaa taataggaag cgcgcagttt tttcaccttg
     1561 ccattcggga gcggcattga tgtcatcatt gatggatcga ttgttatatc ttgatcttct
     1621 aagtgtacaa caccaccgat ttcttctaac aattttttca agatttcaac atctgaaatt
     1681 tccggtaatc cttcgatggt tacaggagat tcagcgagaa tacttgccgg gattaatgca
     1741 acggcactat tttttgcacc gcttattttg acagatcctt ttaatgtttt tccaccaatg
     1801 acttttattt tatccatggt tatctccctt cctactatag gtatgacaga ttcatttata
     1861 atcaagtaat cgttttctcc actgcttcta ttttatcaat taattacata ttatccaaat
     1921 taggatttat taacacagtt ctgtctacgt tataacattt ctgcatgact agttcaacta
     1981 tattattttt ttgatattaa atatatataa atagagtaga taagtattaa ttatacacgc
     2041 aactactagc agctttcaaa atatttgcca gtactataaa aaaggctatc ctgatcggga
     2101 cgttgtactc ccgttatacg gatagcctta aaatttatga ttcgattggt cagtgctaaa
     2161 gccaattcaa caacttaagc tttaccgaca gagccaaatt ctttcatttt accttttacc
     2221 gtgtctttaa tggtttctct tgccggtcca agatattttc ttgggtcgta aagatcagcg
     2281 tttttcgcta gtacttcacg aactgttttt gcagaagcga tttggttttc tgtgttcaca
     2341 ttgatttttg cagttccaag tgagatagct ttttggatat catgtgttgg aataccggtt
     2401 ccgccatgaa gaacaagtgg ttttccagtt aattttgcaa tttcttccat ttccttgaaa
     2461 cctaagtttg gttcaccatg gtaaggaccg tgtacagaac ctaaagccgg tgctagagca
     2521 tcaataccgg tacgattaac cagttcaaca cattcgttcg gatccgcata gataattcct
     2581 tcgccaacaa catcatcttc ctgaccgccg acagttccta actcagcttc aacagatatc
     2641 ccgtgcaaat gagccaattc aacaactttt gaagtgattt gaatattttc ttcaaatggg
     2701 tgatgacttg catcgatcat taccgatgtg aaacctgcgt gaattgctct tgcacatgat
     2761 tcaaagctgg aaccatggtc aagatggatg gcaacaggaa ccgtaatttt atactcttcc
     2821 attaaagctt ttaccattgc tgttactagc ttgaatccgc ccatataacg tgcggcacct
     2881 tcagaaacac ccagaataac cggggatttt tcttcttcag cagcctgtag aattgcttgt
     2941 gtatattcca gattattgat attgaattga cctacagcat atttgcctgc ttttgctttt
     3001 tccaacattt cggtcattga tactaacggc ataatgcaat ctcctcctac atcaaattac
     3061 caatttccat atccatgaaa aaaaatgtaa atgttcaata gaaaatggct cttatttcac
     3121 tcaattatta tgataccaaa atcacaaaca ttttaccatg tgattaaaac tacaaaataa
     3181 aaaatttagt gaacaccatt tatattttat atcttttcta atattttatc cgataaaatt
     3241 tccttaactg ttttagccaa ttcttctata tcaaaaggct ttgcaatatg ggtaagtgcc
     3301 cctaattcct ttgccttatg aatcattttc agatctccgt atgcggtcat aataattaca
     3361 tgaatggatg gatctatttc tttcattcgt ttcaaaattt caattccatc cattcccgga
     3421 atttttatat ccaaaacaac taggtcaggt aaatgcatac ccgcaagttt caaagcaatt
     3481 tggccgtttt ccgcttgata agtttgataa ccttcctttt taaatacctc attaagtaat
     3541 aagcgaatgc caaactgatc atccacgatt aaaatttttc cattatccat tttcgcttct
     3601 cccctatcct ttaaaattcc cttcatcgaa cctgattccc cttcatttat attcgacaaa
     3661 aacttaacta ttccttcttc gttatagaag gaatagcgat gttatagatt gcttgtagcc
     3721 caaggacttg gaaaggagag attaaaaact tgccccctaa tgccaatgca ataaaatgca
     3781 ataagttttt atataatctc cttgtcccat attcagtaaa gtttgagtgg aattatttca
     3841 agaaatattt actcttcggg ctggaaaata tatcgattcg ttcctataaa aatagttttg
     3901 tctacccttg ttcatgaatt tacaggatgg cgttaagacg attttcggtt gagtaatcgg
     3961 ttgtctttct agtatgtacg gatcaaacgc tggaagcaac agacatcagc cgcctatatg
     4021 atgagcaccg ctttcagata gtaatgagtg gcttaatgat ccctttttgt ttatcaggaa
     4081 tagaactatt gaaaattatt catctacaag ttttattttt gctacacgaa attgattgtt
     4141 tataactacc gcaacttctt catccggact tacatctttt atgctgtata cccaaccata
     4201 gtttaaatgc gttcgtttct cgtcttcttc ctttggaacc acttcaactt ttttaagctc
     4261 ttttttgctt agtatctcat tattttcatt aatcgtgatt gtttccgtaa cctttccaat
     4321 cggttcatcc aaatcttctt tcgtaacttc cgcttcttga atcacatagg ttttaccctc
     4381 atagctgatt tccttaaaat tttccatatt caacttatat ttcggcaacg ttttatcaat
     4441 ctccatattc tcggaggcgg tttgtttcaa atcttttaat agggaacagc ctcccaaaag
     4501 aattaccccg gcaacagcca taagcaggat ggaatttttc acttttcttt tctcctcctt
     4561 cccctgtatt ttttccttta ttcataggac ttgccccctt cccaacgatt aaaccaaacg
     4621 aagcctagta atgttacgag aataaaacat atacttgcgg gtatgatccc tttcatcaac
     4681 tcttgaacat acaagtccga caactccatt ccgaatgcat gtttgacctt aagcatcaat
     4741 aacatgggaa cttgcgaaag gcgaacggtc caagcccacg gaatatatgg ccaaatatga
     4801 tcgcccacaa ccgttgcccc aattattgct gaaacaagga atcctccgcc accgatcgca
     4861 atagacgcac ccatcccgaa tgcaaaactg atcagcaaat gcaaggaaaa aagaataagt
     4921 gatccgacca aggacaaaaa cgctccttgc aaaaataaat cgtaatgcac attttctacg
     4981 ttcaaaatat atctcatccc caacaacata aggaaagttg ccaagaatat gtccgcaatg
     5041 gcggcaaaaa taagtaaaga aagttttcca aagtaaaatt tcactcttga aacaggaccc
     5101 gtcaacacat tcatgaaact tcccgacttt tcttcttgat aggccatcaa accggtaagt
     5161 aaagaaatca caatcggtaa cgaaacgctc aatacctcaa aaaatcctcc atatattttc
     5221 acttgccaaa aagatggatc cttatatcta gaaaaatacc ataacataaa aatgggataa
     5281 ataatcggcg tcacaaacac gatcagccta atagctgtac gccttgtctt tagccattcc
     5341 gatgacaaaa catgcaaaaa agacaattca gttcacctct cttctcgaaa accaaaatgc
     5401 agtaacaaga gataataaag caaaaataac aatggaggca agaatgccta ttggaataac
     5461 agaaggatcc aacaaaggat tcccttcttt caacggtaca ccgttcggat gaacaccgac
     5521 gatcggtgac atcaatctca ttccccaact ccacggaata aacatccagt atgattccgg
     5581 agccatgact acccccaaaa caatcccgat caaactgaca attatggaaa taacggttcc
     5641 gaatcgttca gcaaaaaaca acccgattgg gatgtatgcc aacgatgtga tccatatggt
     5701 aagactggcc attacaacga cagctgctga tgaaatgctg ttgggtaaaa ataattttaa
     5761 caggatcaac aaaatcatca gttcaatgga tgaaagcaat gtataatagg caatcacaat
     5821 gattttactg aaccacattc gcggaatgct gatatcgtga caacgtaaag ctctgtaatt
     5881 tcctgacttt ttttctcgca tggcggccag tgacgcgatc aatgccgtcc ccaaaggaag
     5941 aaatagtaac ggccaccaat taaataccgt gtattcgaaa taattatatt tggaatggat
     6001 cgtaggcatg gtaataatgg cgtatagtac aaagaaaaac ggtgcaatat atacaagctt
     6061 tttcgcaaaa gtccgcttat attttaaacg ttcagattgt atcatattca gcatgattca
     6121 cagcctccct cataatccgt tgactacatc gataaagaat ttttccagat cttgatcttc
     6181 ctcgatttct ccttgatatt taagttttcc gttttggatg atgccaatgt gatcggccaa
     6241 ttgttttact tccggcaaaa tatgacttga taaaatgacc gtcattcctt gtttcgggaa
     6301 agatctgata agttttcgta attcttgaat accaagcggg tccagtccat tggtcggttc
     6361 atcgagaatc agaagcttcg gatcatttaa aagtgctttg gcaatcccca atcgttgctt
     6421 catcccgaag gaaaactgcg aggctttctt tttccctgta ttttccaaat ccacgatttt
     6481 cagcacttct ttaattcttg aatccggaag atttaataat tttgcatgaa ccagcaaatt
     6541 ttcataagcc gttaaattgc cgtaaagggc cggtgactca ataagcgcgc cgatctcctt
     6601 aagatctttt ctgctccacg gatgcccatt aaagagaatt tcgccttttg tcggccgcaa
     6661 aagacccgtt aacattttta aaatggttga tttcccggct ccgttcggtc caagcaatcc
     6721 gtaaatcgtg ttttccttga ccctgattga tacattgtca acggcaagct gtttgccgaa
     6781 agctttggtt aattgtttcg tttccaaaaa atacgctgac atggttcttc tcctttcact
     6841 ttaaaaaatg aagttttaac ttttattcgg tcttgaagtc tctcccttcc aaatcttgca
     6901 cagtttgata aaagtgagaa ttgattttac ttcagacctt caaacaaaaa gcaactcgta
     6961 atgtgatgaa agtggcattt gtcgtgcaat tgaaaaactc ccatttcaag tgcgagcgtt
     7021 ctcaaatttc atactaccac ttcaatataa agtttttata atgattttga tttaaatttg
     7081 acacactcta cgcataaaaa actgaataat cagataaatt tcgctattaa gagacgcttt
     7141 atcacttgag aaattaaata aatgtcatga taagtatgta aggggataag atattggctc
     7201 ttcatgcacg aatgcttgtg gcgggaggtc taatggacag ttttttgtaa aagagggcta
     7261 attttgtcct tgagaaggtc gctgtagggg gtctattgga caatttgcac tggatctggc
     7321 ttcattttgt ccaatataag ccatttaatg gacagttttc gtaaaagaga acctctatct
     7381 gtttcttaaa atttaggata ctcttagctt ctggagtaat agacggagat tatggggggt
     7441 gcggaaataa tttcaccata tggattaagt tactttacta tgggtattca gtccctgacg
     7501 gaactggaga taaatattga attttctggt attttttgga atgatttgtg tagaaaagca
     7561 ttaagaaaat gccttgaatt tcatggagga acgtaaacgc caaatgatcc tcgccttaac
     7621 taggtaggaa cgcatttggc gcttgccaac tttttgaaac tttaaaaata gggggagata
     7681 cctcttttta taacagctgg aatctgtcaa catccttatt ataaaaatcc ttctatcaaa
     7741 aagatgattt ttcactcaat tgataacaaa taatggattg ttccttgata taaaactcaa
     7801 cggttgcacc accgttttcg ttattgtacg cctgaatctg tccatcaaaa ttattgacaa
     7861 tttttttcga aatataaaga cctaagccga catggtcttt atattgcaca tcttgataaa
     7921 atgctttaaa taactgagaa gtgtctttct ccttaaatcc agtccccgta tccgaacatt
     7981 taaaataaat tttgcttgaa tgaccgtcgg attcatcatg tacctcaagt ttaatttttc
     8041 cactctttgt aaatctcaga ctgttatata aaatattatc caaaaccctc attagcatgg
     8101 cttcatcaag taaataatat tgtttgctta agcagacatc aaagagaatt tgaacacttc
     8161 tttggtaatg tgccatggtt aatatttctt gttttttctc atgaagcatt ttacctaaat
     8221 caactttttt aatattcaac aaaaaatcca cgttttccac tttatataga agcgacaaat
     8281 tgtccgtaag catgctcatt ttgctgcaat ttttccgaat aatatctaaa tgcggggtaa
     8341 tatcaaattt ttctatgtct ttcaaatcgt taattaaatc catttgccct tgaataacag
     8401 ttaacggcgt tcgtatgtcg tgggcaatcg acgacaccat gatttttcgt tcatcatcga
     8461 tcttggatat actttcaatc atctctttca aagcgtcgat catcgtatta aacgaatctt
     8521 ggatcctcat aaactctttt cttttcaatc ccgagatctt aaaatcaaaa tctccgttgg
     8581 aaattttatc cgcagcctga agcaacactt taatattatt aaacaaggat ttatacagct
     8641 tggacgtata aaaaattaaa taaatcacaa aaaatattaa cggagaaatc aacaacacaa
     8701 cataaataaa cacgattccg aggcgatcct gattattaat gataaacccg aaaggagctt
     8761 tcagcacata caccgcttga atggcattat catgtttaat ggggataaat ctgtaaacgt
     8821 agcttccttt tacaatctca cgattaatta cttcaccgac tttcacttta tatcccgcaa
     8881 catcctgatc gccgtaaaga tgattgccat tgatatccaa tacttcccct tcaatttttt
     8941 cactgtactg atctagatta attagctccc cgtttaaaat gtccggagcg ctttcttcaa
     9001 tctttttttc aataacatcc aaatatttca caaaataatc cgtcggttta atcgtattat
     9061 tttcggcaaa cataaagata aaatagatta aacataaata agtaactgcc gaagacaaaa
     9121 tcgttgataa aaagaccttt acaaccaata aataaaaatc tctttttatt gttttatcct
     9181 ttttcatttg taacatccca tttatagcct aatccgtata atgttttaat ataggagttt
     9241 tccttatcca aagaccggat tttcttccga atgtttttaa tgctttccgt caccgtttct
     9301 aattgacttt ccgaatccaa tccccatacc cgttcaaaaa ttctatcctt agaaaagacc
     9361 atatttttat tcaacattaa caatttaata atctcatatt ccttttttgt taaatgcaat
     9421 tgaacccctt tacaaaagac ttcattggcc aaaagatcga tggtaatatt tttagaactt
     9481 aacaaatgcc tgtcattcga acggatccgc tcttcccgtc ttaaatggga atcaattctt
     9541 gctttcaact cttttaaact gaaaggtttg gtcatgtagt cgtccccgcc gatggataga
     9601 gcttgaactt tgtcttcctc caacgttttt gcgctgacaa aaataatcgg acaattcact
     9661 ttgtcacgga taatcccaca caattccatt ccatcaaggc cttccatcat aatgtccaag
     9721 ataatcaaat caaaatcatt gttaatgatt tgcaatgcct cggtgccgtt atgtacatat
     9781 tccaccgtgt aatgataaag ttccaaatat tgcttgattg taagacaaat atcttcatta
     9841 tcatctacaa ctaaaatttt cttcaaatgc atgcttccag atcccacctt attatcgttc
     9901 attgaaattt gaacattttt caagtaattc cgtattcatg cagatagggt accctcttaa
     9961 aatatcagag aataccctgc ctttttcttt tatccatatt ttaaactttg gataataaaa
    10021 aagcgctgtc ccaaggcgtt tttttaccgt tttggatcgc taacaacgtc aacaaaattc
    10081 ctgccgttcc gtctattaat ccaacataat cataatattc cttgcctttt tcgcttcctt
    10141 caatattttt aaaaccaaat ggatattcct tattataata tttcattatg tcatttgcca
    10201 atgtaagggc agtttgacga aaatcactga tattcgtttc ctcataaaat cgattgcaga
    10261 tgtatgccac accggccaag ccatgacaaa aggagggaga aaaaatgtcg taaagccgct
    10321 tgcttgccag ttccattcct cttatagcac agtcaatata cgtctgatta ttcagcgttt
    10381 ttcctgcgat aagcaatgaa taagcgactc caggggtccc gtagcaccat gcatctcttg
    10441 tatttttgtt caagactgtt ccctgatagt attcttccaa agaaacatgc gtcccccaat
    10501 aaactccgat ttcatcttta atttgaaact tgatcaaaaa atcggctatt ttttgaatac
    10561 attcatctag tccatccgtg taaatattca gttttttggc attgcacaaa ataattaata
    10621 aagcaggtat gccgtgagag agcccaatgt taatgaaacc ggacggccaa tttctttttt
    10681 ccctttccga aaaagcatgt tcaggaagaa tataccatcc tggaatcctt aaatcttcca
    10741 tctctttgtc ttgagacaaa tcaattatat attttaagat caaagtaatc gtttttttca
    10801 tttcttccgg aaataacaag cagtacccgg cgataccggc aactcctgaa atagcatcat
    10861 aatcatccat attcggatat gatttctgtt ttaaattagt aatgatttct tccatttttt
    10921 cttcgatgac gatatttata tttgcgataa atttttgata tctttttccc tctttggata
    10981 aacagaccgc tgccagagcg accccagtca atccggtgaa catggataat gaggaaaatc
    11041 cgttttgatt aatttgttcc ccaattcgtt tcatatattg atgtcccaat gcatcccaat
    11101 cttcatcggg gtagtgttcg ctcatctccc cgtagagcgc gcataaagca ggtaaaccat
    11161 ggcttaaact taattcatga aacggattga tccttttgtt tccgatttga agaaaatttt
    11221 tcgggtgatt tacgatctgt agcatattct cataatccga taatttccta gcaatattac
    11281 agactggctc tttcactgaa acgctcatat tccacctcgt tttgcataga ttccaattca
    11341 tacattcttc tgtataaatc attcgtagcc aaaagttcat gatgggtacc gatcccgata
    11401 atttccccgt cgttcatgac gacaatttta tcagccagct tggccgtcga taaccgatgt
    11461 gagataaata taccaatttt atcttttgtc atatccaaaa acatatcgat aacttctttt
    11521 tccgaaatgg gatccaaggc tgagctcggt tcatccaata tataaacgga tgcgttgcga
    11581 aagaaggctc tggcaattgc caccttttgc cactgtcctc ccgaaagctg cacgccgtcc
    11641 acaaaccata aaccgagctg tgtatccaaa tctttgataa agtttaattg cgctctatcc
    11701 atcgcttgct ttaattcttt gtcttgttct atgcgcgtaa tatcaccgaa tcccacattt
    11761 tcccttaatt ttaattcata tttcacaaaa tcttggaaca acactgcgat gttttttctc
    11821 aattgggccg tatccaaatc atggatcgac acatcgttgt aaaaaatgct gtcttcatca
    11881 tgatcataca atttcaacaa aagtttaatt agggtgcttt ttcctgatcc gttggccccg
    11941 acaatcgcga ttctttcacc tttatggata tcaagattaa tattttttaa aactactttc
    12001 gaattggtcg gataactgaa ggttaaattt ctgattttta tattttcaat tttgtcgacc
    12061 cctaatgcca atcggccctc tttattcaat acttcctcat ccaaagccaa aaattcaaac
    12121 agttgaataa tgtacagatt atttttatac agagaatgaa tcgtatttaa tattattctg
    12181 gagttattgg aaattaaatt caacgcctga ataagcccga caacatgacc gactaagatt
    12241 tctcccgcca acgccgaaag aatgacaatc acaagtacgg tattaataca tatttgttca
    12301 acgagctcaa agataaaggt aaaaatcgtt cttcgtttaa aaagctttat atcttgaccg
    12361 acaaactttt tgttgatttc tttaaattgt tttaaaatat aacccgccaa attatataat
    12421 ttaacttctt taaacgtatt gtctcttgtc attaagtaag ataagtacca ggattttcgt
    12481 ttttccggtg cacggagcca actgacatta aactcccttt gaccgatctt aaaaaagtat
    12541 aaagaaaata taaccggtat aaaaattaag ataattaata cccaaggttt ccaattaatc
    12601 aggatcatca cagacgagaa aagagtgaca actgcggata tggtacctaa aatggacaaa
    12661 aacacttcaa acggtttata aggtgtctca ttctgaactc tttgcaacat atcataaact
    12721 tccgcatcct cgaaatgtct taaagacaac ttagtacact tgtccatcac ttttaaattc
    12781 agcttataat tgattaatgt ttgaaattta ttttgataat attccgtaaa accgctgatg
    12841 atttcgctga acaaattggc aaaaatataa aagattaacg cggaaatgat tatgcgaata
    12901 ttttggaacc cgattgcatt cagcaaattt tgcgaaccga ataaggtaat aataggggcg
    12961 atccccatta ataagcttag aaaaataatg atataaaaac tttttttatc gacatttttg
    13021 atgagcataa gcgtcttggg gaccatcttt actgacttca ctatatcttt tacggtcact
    13081 cgatcatcat catattctct tatatccatc gtttttcaat cctcacatgc tagaattaaa
    13141 ccttattccg gccatcacct aaataaacgg gaaattactt gttaaactcg taaactcatt
    13201 tgtgcaaact ccgcgagctt gcacaatgaa tagaatcttt atttttccaa aactacttca
    13261 tgaagtttaa tatattttga tgcatataac gtatgcccga ccaaagtacg gactttcttt
    13321 tcaaattccc ggtcaatgcc aaacaatctg ttacagtgca aatgaatcac gctgtctaaa
    13381 atggataatt ccgaagaagc ttccagacct tcccggatct tcttcgcata tgctttaata
    13441 ctatcgtttc tctgatttaa aacatttaat aataacgtcc cctcttccgt ttctcttaac
    13501 cctttccaat cattgtctgt attgcatact ttcatataat aagagcgatt ctgtttaaaa
    13561 tcttcccggt agtcctgttt gtttacttgc tgttgcatga agtccaattg gctttcatac
    13621 tctaagccga actgttccat ataatgaata atggaaacca ttccgattac ttcatcactg
    13681 aagttaatcg tttttaaccg tttcagtttt aaaatatctt ctgttacaat gctatccgta
    13741 caaaataagg tttccgcaaa atggatcaat tcccttccgc cgtagcgttc aatttctttt
    13801 tcatatgtgt caatggagaa acgactcagc aagccttttt ccattaaagt cctgagccat
    13861 tgtttgatat cgggatacat ctgtaacaat ttcccttcac tggcattgag ccttaatcgg
    13921 atatgttgtt ccgggtcggc gtagcgcata aaaaagtatt tttcaatttc tccttttgcc
    13981 cacttttccc gacagtattc tgaaatataa aaggctatta aatcatccat gttggagtta
    14041 acaccgtaca atttcagata tatccaatct tcaaaaggca gttttaccct ttcatccgat
    14101 aaacttggaa tctgatgaga tttcttcggt ttaacgtagt gctcattcac ttcttgctta
    14161 acttttacca aaggaataac catttcacaa atatattctt catcagcgtg atctttcacc
    14221 agattcagac cgccatcctc ataagaactt aggatgatat tgctgtatct gttgttaaat
    14281 tgatggtgaa gaattcgtat acaatgttca tcctcggaat tcagcaaaac ccgattatcc
    14341 gcaaaagtta aatacacaaa cttaggcaca tgatactcca agcaaaactt cttaaaccgt
    14401 tcttcaaaat ccgcaaaatc cattttgctg tttgttttga taatcttgtt gagcacccat
    14461 ttttctggtg agatcgtaaa atttttgtat tcaattttcg ggatgtacga atattcagaa
    14521 aagattatat cccaaggaaa attataccaa atttttttgc cgtccaagct taaatcgtac
    14581 aagaaacgta tcggattggg ggctgttcgt gtattcagca tattattgat cgtaatgagc
    14641 aattttttat tgagcgtttt gcttttcgca taaaaaagat cgttttcgat gccgatcaaa
    14701 atatcattta aacttaaccg atgctcttca tctctgctgt tgttggtaaa taaagcgagt
    14761 tcgtattcgc tgtgatgaat atttcttgtt acatttgcat ttctcgtttc attcggcata
    14821 tacacaattt cacaggtgac atactcatcc gaatcatcat tcaagtttaa aatttcttcg
    14881 tttaatgttt cgaaaagctt ctcttcgcca tccatcatat aagcaaatct tccaaaactt
    14941 tttcctgcat gggtagcccc taaattcggt ccaagataat aggtaaagcg attgtccgca
    15001 atatcttgat cagagttaca tttcacgatg atgttcatgt ccaatgaatc cggaatgctg
    15061 ttgtaattat aatcatccaa tcctaattct ttgatctcgt catccgtaat cataatactt
    15121 ttcttatctt ttaccgcttc tacatatttt tgaagaaaat aatctcttaa ctgctcatcg
    15181 gttgatggtt gaaccattcc ggcattgatt ccggcgtttt tcggattttc ataatccacg
    15241 ggtgcaccta tgcctaaatc ttgatcaagc atttccagta acggtacttc tctgtccacc
    15301 ccatatttct cgataaattc ttgcttatac cttgaaaacg gtgaatctgt ttgttgatac
    15361 gtcatagaaa agggtaaaag catgcgcatt aatttgttta aatctttgat cactttcttg
    15421 ttcagcttct tttcctgcaa atttagtttc gcatcaactt gcaggacata ttttgacttg
    15481 accaattgtg tcatttttct atgtaagtct ttatatattt tttccccttc accgaaaggc
    15541 gtcatggtat attttcgaat ttcttcttga atattggtta acgcgttgac ccattcttcc
    15601 aaattgcttt ttttcagttc tttgatcaaa taatccaatt gatccatcac ggttaacggc
    15661 ggacgaagat tggaaattaa aaactcattt ttgattaatt gctttaaaaa atgttcaatt
    15721 ttttcctccg tggcatttga aaatcttgtc attaattcat tttttaattt ttggaaagga
    15781 attaaacggc cagccaattg ataggtcatt tcaaaaggag acgttatcct gacactgatt
    15841 tcgtttactt tcttgtcggt gtcttttatc gtcgaatgca ataaataagc ccgttcgcct
    15901 ttaaaaaaga tactatcgtt tatcttgaac cataattgcc catattgttc ctgctccagt
    15961 ttttttacga tcttcataat ccattccaaa tccggacgcg caaatttttt atacttattc
    16021 gctccgaatt taattaaggt agtttcctcc gtaaattcgc caaagtcaat gcctgcaaaa
    16081 agaccgaacg gcgttggtct cgtactcatt cttatcaaat acttataaat ggctttaagg
    16141 aaataatcat atttttttat ttttttaccg ttgcaaaaat caagcatttt attatataaa
    16201 cttttacttg cagccaagat actttgtcta aaaaatggat cgttgcaaat ttccaataga
    16261 tgttctttca tctcttcctc ggtaagtttt tgatcaaaaa atttcaagta aatgttcatg
    16321 gataatactg gagttcgaat cataaatgta tcaatgtctt taaaaatctg ttctttcata
    16381 aacatagtcc ccccatttta tggtttgcaa ggcttatttt acacggaacc tttacttaag
    16441 tatgtggatt ttctagcatg tatgaaatga tgaaaaaatt tccaaacacc ttcacaagat
    16501 ttcgtcaatg ttgtgaacct gattctcttg cagattttat tttccatcac tcctctgcca
    16561 ttgcattccc gaggaacgga gaagagagag gaatcataaa ttcggatatt aatgattgac
    16621 attgaatatt ttctacacaa aacttcatac ttccttgatt atgtaaaaaa taaataggaa
    16681 gcaattgcag taacaatgga ttgtaaagga acaaaacgaa aaactttcaa ggcaaattaa
    16741 gcttaaaagg ggaaattttg ccgattggtg cataatttta tagaaaaaac atattattat
    16801 aacagaaaat gatttcacgt ttattgaaaa agatagcaaa atacatacct tttttgctat
    16861 cttataagag caccgccagc ataaaagctg gcgaccaaat cttgatgaca ttataaatac
    16921 aaacaattaa catttgatgc aagagttaca agatacacag gagttttgag ttaagcacat
    16981 taaaatacct gtgatacaac caggcgtaca aagagattta cttgtaacat tcggttgtac
    17041 agtggtatct tgttttttga caacgatgtc caaatcgaaa tcatcaaact tagccatccc
    17101 gttacacctc ctttccatct tggtatctat cattaactac agatgatgaa aggacttgcc
    17161 cttcaagaaa tctcttaccc tctcatcaag tagttaacac tgaaacggaa acatctcttt
    17221 aatattaaat taaatagaaa atctaatatt tttctaatgt tttatattat tttaaagaaa
    17281 tattgagtat ttcttttgcg atcactcaaa tgctattaaa ttataaatct tcaaaaatat
    17341 actttgttat tatggagtac ttaacactta gtactgcttc tggtgttacg gatataatgg
    17401 atttaagtca aaacgtttgg aggaagacct ttagttgaaa attgaaagaa catattctag
    17461 tttttcagta gcccgaaata agaaaacttg gcgattgccg agtctttaga cgagagcaga
    17521 gctgtagttg cacttattcg ttaggaaagt agaaattgta aaatttctac tttcctggtt
    17581 taaaaaccca atttgtgaaa tttgattatt tattggttta ttttcaagaa aatcagattg
    17641 ggtaagagtc acctttttct tgaaacaaga taaaaatttt tacattgcaa aaagattagt
    17701 atagatttat tcttttttag agaaggtgtt tttgttaaaa tggggtgaaa ggagtgaagc
    17761 ggtttgtcga aaatatttac tacgcaattg attgggcgtt tacaaaaaat tagtgaacaa
    17821 gaacttgata tagaggatgc agccagattg ttggctcagg cattagttgg tgaaggttcg
    17881 atttatattt ttggtgaaaa tgatttgaga agtgtttttt tggaggctaa atatggacaa
    17941 gagcctttgc aaagagtgca agaatggacc ggtgatacat ttgaacagct atcgacggcg
    18001 gatcgtgtgt taattttttc acgaaatatt gctaatgagc aagttgtggt gctggctaaa
    18061 aaactgcgtt cgcttcaggt gccgtttgtt gttgtcggtt caatatctgt gaaagacgta
    18121 aatccagtag aaaatttagc tgatgtatgt atcaatctcc atattgacac cggccttgtt
    18181 ccggatgagc ggggtggcag aacgatgtat ccgcatgcga tagccgcatt atatgtttat
    18241 cattcgttaa aattccgaat tgatgaaata atggaagatt atgcatttgg ttcttaacat
    18301 aataaccggt ttattggaca gttttcgctt gatgatttcg cattttgtcc ataatagccc
    18361 ctctattaaa aaacacccaa aaaggcttaa agaaaaattt cactaaatgt agtgaataag
    18421 ctttttgggt gcgaacctat ggtagtttca ttattttttg aacaattctc tttctaattt
    18481 agcgttggcg aaggatgcca aatgaacaaa cttattttcc ttcccgatta tttaaagatg
    18541 aacggataaa ctctctgaac aatggatgtg gttttgtcgg tctcgattta aactccggat
    18601 gaaattgcga tgcgacgaac catggatgat cttttaactc aataatttca actaaacggc
    18661 cgtccggact aactcctgaa aaaacaaaac ctttttcttc cattatttga cggtattggt
    18721 tattaaactc atagcgatga cgatgacgtt cataaatgag ttcatcttca tacgcattaa
    18781 atgccttcgt tccttctaca attttacatg ggtaaaggcc aaggcgtaat gttcctccca
    18841 tatcttctac atcttcttgt tccggtaaaa gtgctataat cggatgtttt gtgtccggat
    18901 taatttcaga actatgagca ccgtttaatc gaacgacatg acgagcaaat tcaatggaag
    18961 ctaattgcat tcctaagcat atcccaagga aaggaacttt gttttcacga gcgtattgaa
    19021 ttgctgtaat cttcccttca attccgcgat caccaaaacc gcccggtacc aaaataccgt
    19081 ctgcatcacc aagtaattcc gccacgtttt cttcagtcac atgttcagca ttaatccaat
    19141 gaatatctat atccgagtca aatacataac cggcatgctt taacgactct acaaccgata
    19201 tataggcatc ttgtaattcg acatatttac cgaccaaggc aattttcacc gtcttggaca
    19261 agtttcgaac tttatttacc aatgcttccc attcggacat attcggttca tggctgacga
    19321 tttttaaata attgcaaaca atggtatcca aaccttggga ctgcatagaa agggggattt
    19381 catataaagt atccgcatcc cttgattcaa ttactgcttg cgaatcgatg tcacagaata
    19441 acgcgatttt atctttcatc tcttgggaaa ttggcatttc tgtgcgtaca acgatgacat
    19501 ttggttgaat cccgagactg cgtaactctt ttacactatg ttgtgttggt tttgttttca
    19561 tttcaccggc tgctttaata tatggaacaa gcgtgcaatg aatatacata acattagatg
    19621 aaccaagatc gctctttaac tggcgaatgg cttccaaaaa cggtaatgat tcaatatctc
    19681 cgacggtccc gccaatttct gtaatgacaa catcagcatt tgtttctttt ccggcacgat
    19741 agacttggtc tttgatttca ttggtaatat gcgggatgac ttgaacagta gcaccaagat
    19801 aatccccgcg acgttccttt tttattaccc gtgagtatat ttttcctgtc gtgacattgg
    19861 aatatttatt taaattaata tcgataaaac gttcataatg gcctaaatcg aggtctgttt
    19921 ctgcaccatc atcggtaaca aacacttcac catgttgata cggactcatg gttcccgggt
    19981 ccacattgat atatggatca aatttttgaa tggttacttt taaaccgcga ttttttagta
    20041 agcggccgag tgatgctgca acaatccctt ttcctaaaga tgaaacaacc ccgcctgtga
    20101 caaatacata ttttgtcata atgaaatctc tccttactat tttttctaat catagtttac
    20161 aaaaccagtg gttactttat aaaaaaaaag aaaaaacaaa aaagccccac ttactgatgt
    20221 aagggagcta tttgcttttt taaaatgaac aaatatattt ttattgagcc caaatagaat
    20281 aatacatagg aaaagttaaa atgtcaagaa tgtgctcaca attcttcgtc ttcttcatca
    20341 atgtattcat cttcatctat atcttcttca tcgtccaact cttcctcaaa ttcctcatcg
    20401 atgattagtt cctcatcttc ttcctcaaca atatcttcgt catcttcaaa tacatcatca
    20461 atatcttcaa ggtcatcttc ttctataaat tcatcctcat cttcatcctc atcgatgaat
    20521 tcatctaaat cttcttcgta ttcaacaaga tcctcttcca attcctcaaa atcgtcttcc
    20581 acttcatcaa cttttgcctt tttctttttc gaacggactg tcggaacaaa atcatcttca
    20641 tattgttcta ccggatacca tcctttatat ccccaaatat taccgccgac atttaaaaac
    20701 cgaccgtcaa tgttcaaatc cgtataaaat tgagcaatat ttgcctggac ttcttccttt
    20761 gttgcaccca ataatttagc aacctcatct actaaatcat ttaggtgcat aggttgtttt
    20821 ctgtcataca aaagttcata tgcgatttcg attaatgaca tttcctgtaa ttgttcttgg
    20881 gttaaatttt ctaaactcac ttgtgcacgt cctttctctc ttaacaaaaa cagaaaagat
    20941 ttctttacgg aatgattgct ataaaaactg gatacccact cttcatgcat attattcatt
    21001 ataaacaaaa gttatctgtt tatgctagtc tgtgtcattc gtcaaataat gatattttat
    21061 ggcgtggaat tagtcacctt ttttatattc ttgccaggca atatagataa aaaatataga
    21121 gagaattaaa aatggaatag cacccagctg catatcatag aaaaaagata ttccatatat
    21181 agagagaata attataacga cgattagaag atatttcaag ttcatttcac ttcccaataa
    21241 cgacatcttg gggtagagat aatcttattt ataaaatccc tatttccttc tttcctacca
    21301 attttattat aaaacaattt attgtcaatt tttagatgtc cggcgaaaat attttttttc
    21361 gtatggtgaa acattaaagt tagttttaaa gttcacttct ttaattatac tcggctaaac
    21421 tgaacctgaa aagcgttggc ttcacacctg aaaaaccgaa aaatgaaagc aggggattcc
    21481 gactttgcat catatgagtc ggtactcccc tttttgatat cttattttag tttatcattt
    21541 tttgccgtat ccggtttata catttcttcg atactggccg ccgacttcgt acagagcatt
    21601 ggtaatttgc ccgaggctgg cgacttttac cgtttccatc aattcttcaa aaatattccc
    21661 cccggaaaga gccacctgtt ttagtttccg caatgcatct tccactttat cttgatttcg
    21721 ttctttaaat ttcattaagt ttttaatttg agtttctttt tcttcttttg aggcccgggc
    21781 tacttggata ttatttattt cttcttcttt tggcggattc ggatttaaat atgtgttcac
    21841 accaatgatc ggcagttccc ccgaatgctt tttcgtctca taataaagtg attcatcttg
    21901 aatttttccg cgttgatatt ggctctccat cgccccgagg acaccgcccc ggtcattcag
    21961 tcgctcaaat tcctgtaata ctgcttcttc gacaagatct gttaattcct caatgatgaa
    22021 ggaaccttgc aacggatttt catttttggc tagcccatat tcttttgtaa taatcatttg
    22081 aatggccatc gcccgacgta cggattcttc tgtcggcgtt gtaattgctt catcataggc
    22141 gtttgtatgg agtgaattgc aattgtcata aatcgccatt aatgcctgta aagtggtgcg
    22201 aatatcatta aaatcaatct cttgagcatg aagggaccga ccggatgttt ggacatgata
    22261 tttcaatttt tgactccgtt cattggcccc atatttttct ttcatgacaa tcgcccaaat
    22321 tctccttgct acacggccga taacactata ttccggatcg agcccgtttg agaaaaagaa
    22381 tgacaagttt ggagcaaagt catcaatatg catgccacgg cttaaataat attctacata
    22441 cgtaaagccg ttcgccaagg tgaaggccaa ctgggtgatc ggattggcac cggcctcggc
    22501 aatatggtaa ccggaaatgg ataccgagta atagtttctg atatgatgat cgataaaata
    22561 ttgttgaata tcccccatca tacgtaaggc aaattcagtc gaaaaaatac atgtattttg
    22621 cccttggtct tcttttaaaa tatccgcttg taccgtaccc cgaacggttg acaatgtgta
    22681 ggctttaact ttttcatatt cttcttcggt taatggtcgc tctaattctt tttccttaag
    22741 ttcaacttgc tgttcaatgg cggtattcat gaacatagca agaataatcg gcgccggtcc
    22801 attaatggtc atcgaaacag atgttaacgg gtggcataag tcaaatcctt gatacaattt
    22861 tttcatatca tctaaggtac aaacactgac accgctctcg ccaacctttc cataaatgtc
    22921 aggtcgataa tccggatcct caccgtacag tgtaacggaa tcaaacgccg tacttagtcg
    22981 tttggccggg tcatcttttg acaaataatg gaagcgccta ttggttcgct ccggtgtccc
    23041 ttctccggca aattgacgtt tcgggtcttc ttctttccgc ttaaacggga acactccagc
    23101 cgtaaaagga aatgcacccg gaacattttc tttatatacc caacgtagaa tttccccata
    23161 atccttgtat ttcggtaaag cgactttcgg tatccataaa cctgaaagac tttttgttcg
    23221 taattcagtc gttatttctt tatcacggac tatagtcacc agccggtctt ttgcgtatgt
    23281 ttcttttgtt tgatcccagt tttcaataat ttttttcgaa gtatcattca gcttgtcggc
    23341 catcttgttt ttccaagctt ctaatgaatc aatgagcgcc ccttctgttt catttccttt
    23401 agttagctcg atggtacctt cgatttggaa aagttttctg gcatattcaa cttgttcttc
    23461 aaccctttta tgataatttc tgacactatc agcaatctcc cgtaaataat accgtctact
    23521 gtttgggatg ataatatcat gtttttcaac aacctctttt ttggagtagg ttgttgacca
    23581 gcccaagtgc agcacctcat taaatttctc aatgatagct gcaaataatg cgtttgttcc
    23641 cggatcgttg aattgactgg cgatggttcc ataaacaggc attttttcgg gcgcttcatg
    23701 gaaaagttca tgactgcgtt gatactgttt ttgtacttgc cttcttgcat cctctgatcc
    23761 tgttttttca aatttgttaa tggcgataag atcagcatag tcaatcatat cgatcttttc
    23821 taattgggac ggtgctccaa actcacttgt catgacatag agggcgacat cgctaattgc
    23881 gcgaatttcg gcatcacctt ggccgatccc gcttgtttca acaatgacaa aatcaaatcc
    23941 ggatgctttt gtaattgcta aagcatctcg aatggcgagt gacaattcac ttttggagtc
    24001 acgggtagcc aaagaacgca taaatacacg cggtgaaaaa atggcgttca ttcgaatgcg
    24061 gtcaccaaga agcgcaccgc cggttttttg tttcgttgga tcaaccgaca aaatggccaa
    24121 ttttttttcg ggaaattcat ttaaaaaacg aaggaccaat tcatctatta gggaactctt
    24181 tccagccccg cctgtaccgg taataccaag aaccggtacc gcttttttcg cttccttgac
    24241 cttttctaaa atcgtttcaa gtcctggagc caattcacca acatttgttg cgatccgttt
    24301 gtctgataaa tattccgcca atgtaatcat tttggcaatt gcgtattggt tttggttttg
    24361 taaattcaca acttggttgg ctacttcctc attgattgtt ggaaaatcac attgttcgag
    24421 catgaggtta atcattccct gcaacccgag cacacgtcca tcttccggtg aaaaaatgtg
    24481 agcgattcca tattcatgta attcttttat ttcttttggc agaattacac cgccaccacc
    24541 gccaaaaatc cggatttgtc cggcaccctt ttcatgaagg agatcataca tatatttaaa
    24601 aaattccatg tgtccaccct gataagaagt aaccgcaatt ccttgaacat cttcttggat
    24661 ggcggcgtta acaatttcct caacagagcg gttatgtccc agatggatga cctcggctcc
    24721 actcgcttga agaatccgcc gcataatatt aatggtcgca tcatgaccat caaacagact
    24781 ggatgctgtc acaaagcgaa tcggatgttt tgcttggtaa acctttgtct ccatgctttc
    24841 tccccctatc cccttatatg aaaaaatgtt cttaattaaa acccgtaact cgtagtaacg
    24901 aatacttttt gaactacgtg tcaaaaattg ttttctggtc agatttatac ctgcaacacg
    24961 aaaaatgctt tttgccttgc gtttaagctg gcttaaatgg atgatctctc tttttcccgg
    25021 agaaagtttg caccccttgg ataaacagtt caacctgcat attggtatat tcatctagtg
    25081 tgtatatttt ttgtaatgcc caccggcgga agctccacat ttgcccatga acaaaaatat
    25141 tatgagccaa caattttatt tctttatcct ttaaaagcag cccgtagttt tcactaaaca
    25201 atttaatcaa ctgttcaaac atagccacca tttgcatttc ctttttcaaa acatatggca
    25261 acgattcttt tgtcaatgat ttcgcctctt gatataacac caaaacctca tcctgcattt
    25321 catcaatcac caggaaatat gaagtaattc cttcccgaat cgtttcaatg gtgacttttt
    25381 tcaaatcaag tgcgtcctga attttcgact gaacttcatc atatatttga tcacaaacta
    25441 aatataaaat atcttccttg gaacgaatgt attcataaag ggttccaata ctgaaaccgg
    25501 ctttgcgggc aatctccctt gtcgtcgtac gatgaaatcc cttctcctta aaaagagaga
    25561 tggccccttt aaccatttgc tcccggcgaa tattaatcag tcgctcatct tttacggaag
    25621 cgtagacttt ttgtttttct gccaaaggac cacctgcttt ccgttaagat tttcttgatt
    25681 agagcatccg ggaaatgact aaacgctgaa tttcttgggt accttcataa atttgagtta
    25741 tttttgcatc acgcataaat ctttccaccg gatattcttt tgtatatcca taaccgccga
    25801 aaacttgaac agcttcggtc gttaccttca tggctgtatc tccggcaaat aatttagcca
    25861 tggcagacgc ttttccataa ggcagtccgg ccgattccaa ccaagctgct tgatatgtta
    25921 atagtcttgc cgcttcaata tttgttgcca tatctgctaa tttaaacgat atcccttgat
    25981 tggcgataat cggtttccca aattggaccc gttcttttgc ataactaacg gcagcatcta
    26041 atgcaccttg ggcaataccg actgcttgag ccgcaatccc gtttcttcct ccatctaatg
    26101 tcatcatcgc aattttaaag ccttgacctt cttcacctaa aacattttct tgcggcacga
    26161 tacaatcttc aaaaatgatt tccgttgtcg gggatgaacg aatgcccatt ttcttttctt
    26221 ttttccctac tttaaatccg gaaaagttgc tttctacaat aaatgcagtc gtccctttat
    26281 gttttgactc agggtccgtg gtggcaaaaa cgacataaat ttcagcaact ccgccattgg
    26341 taataaatat tttcgaaccg tttaaaacgt aatgatccc
//
