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Overview
1.1
1.2
1.3

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP023704.1 (Caldibacillus thermoamylovorans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | terpene-precursor | 2,433,896 | 2,454,756 |  |
Region 2 | lanthipeptide-class-i | 3,805,144 | 3,831,522 | High | geobacillin I | ribosomal:RiPP:Lanthipeptide
Region 3 | betalactone | 3,899,226 | 3,923,547 | Low | fengycin | NRPS:Type I

NZ_CP023704.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,433,896 - 2,454,756 nt. (total: 20,861 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carbamoyltransferase carboxylase
CQJ30_RS12015: ornithine carbamoyltransferase

smcogs
  SMCOG1114: ornithine carbamoyltransferase

CQJ30_RS12070: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
CQJ30_RS12035: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

CQJ30_RS12040: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Translocases: permease
CQJ30_RS12010: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000895.5 |  | 0.43 | other (other) | citrulline | Lactobacillus plantarum subsp. plantarum
BGC0002284.3 |  | 0.42 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000665.5 |  | 0.41 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000663.5 |  | 0.40 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001594.3 |  | 0.40 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000895.5 |  | 0.43 | other (other) | citrulline | Lactobacillus plantarum subsp. plantarum
BGC0002284.3 |  | 0.42 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000665.5 |  | 0.41 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000663.5 |  | 0.40 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0001594.3 |  | 0.40 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
CQJ30_RS12040: PT_FPPS_like
Domain 1 (25 - 285): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.70 out of 23.79
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.86 out of 24.78
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84
Confidence: medium
Additional weak hits (5):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.52 out of 30.11
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.64 out of 30.97
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.84 out of 32.93
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.98 out of 24.78
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
MexT | Global virulence regulator

NZ_CP023704.1 - Region 2 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,805,144 - 3,831,522 nt. (total: 26,379 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase dehydratase
CQJ30_RS18300: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

CQJ30_RS18310: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000515.4 |  | 0.80 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000542.3 |  | 0.60 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.60 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001289.5 |  | 0.60 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001789.3 |  | 0.60 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.59 | ribosomal | nisin U | Streptococcus uberis
BGC0000538.3 |  | 0.59 | ribosomal | nisin Z | Lactococcus lactis
BGC0000506.4 |  | 0.59 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  | 0.55 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000515.4 |  | 0.80 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0000542.3 |  | 0.60 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.60 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001289.5 |  | 0.60 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001789.3 |  | 0.60 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.59 | ribosomal | nisin U | Streptococcus uberis
BGC0000538.3 |  | 0.59 | ribosomal | nisin Z | Lactococcus lactis
BGC0000506.4 |  | 0.59 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  | 0.55 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for CQJ30_RS18310

CQJ30_RS18315
Leader:
MIDTKMERRCNGMAKFDDFDLDIVVKKQDTTVQPN
Core:
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I K C
Core with dehydrations:
V Dhb Dha K Dha L Cys Dhb P G Cys I Dhb G I L M Cys L Dhb Q N Dha Cys V Dha Cys N Dha Cys I K Cys

#### antiSMASH-DB 4.0 matches for CQJ30_RS18315

100.0%
NZ_CP023704.1:
Lanthipeptides: CQJ30_RS18315_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I K C
33
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I K C
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I K C
33
97.0%
NZ_CP014140.1:
Lanthipeptides: ACH33_RS18880_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I K C
33
V T S K S L C T P G C I T G+L M C L T Q N S C V S C N S C I K C
1
V T S K S L C T P G C I T G V L M C L T Q N S C V S C N S C I K C
33
93.9%
NC_006510.1 and 4 others:
NZ_CP018058.1 Lanthipeptides: GT3921_RS18655_lanthipeptide NZ_CP025074.1 Lanthipeptides: CWI35_RS08795_lanthipeptide NZ_CP027303.2 Lanthipeptides: C1N76_RS05790_lanthipeptide NZ_CP038860.1 Lanthipeptides: E5Z46_RS04660_lanthipeptide
Lanthipeptides: GK_RS18085_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I K C
33
+T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I+C
1
I T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I R C
33
with 94 more sequence matches
Only the first 10 are displayed here.
93.9%
NC_009328.1 and 5 others:
NZ_CP014749.1 Lanthipeptides: A0V43_RS19510_lanthipeptide NZ_CP014749.1 Lanthipeptides: A0V43_RS19510_lanthipeptide NZ_CP017690.1 Lanthipeptides: GTID1_RS08690_lanthipeptide NZ_CP017694.1 Lanthipeptides: GD3902_RS07590_lanthipeptide NZ_PIJH01000004.1 Lanthipeptides: CV632_RS11810_lanthipeptide
Lanthipeptides: GTNG_RS18005_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I K C
33
V T S K S L C T P G C I T G+L M C L T Q N S C V S C N S C I+C
1
V T S K S L C T P G C I T G V L M C L T Q N S C V S C N S C I R C
33
69.7%
NZ_AULX01000006.1:
Lanthipeptides: H583_RS0100280_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I K C
33
+T S K S L C T P G C I T G+L M C T+ +S +S C I K C
1
I T S K S L C T P G C I T G V L M C F T K G C E I S-H S C I K C
32
66.7%
NZ_LT732548.1:
Lanthipeptides: CZ379_RS19505_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C I K C
33
+T S K S L C T P G C I T G+L M C T+ +S +S C+K C
1
I T S K S L C T P G C I T G V L M C F T K G C E I S-H S C V K C
32
60.6%
NZ_CP085954.1:
Lanthipeptides: LK411_RS13585_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S C
30
+T S K S L C T P G C T G L C T Q N C N C
1
I T S K S L C T P G C P T G A L G C F T Q N-C D P T N G C
29
48.6%
NZ_CP113114.1 and 1 other:
NZ_FZDV01000015.1 Lanthipeptides: CFW84_RS08635_lanthipeptide
Lanthipeptides: OTU45_RS07045_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S
29
+T S S L C T P G C+T G+L M C + +S C N
1
I T S V S L C T P G C V T G V L M C--P G N T I S C N G
27
48.6%
NZ_JALDTZ010000003.1:
Lanthipeptides: M1F37_RS03135_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N S
29
+T S+S C T P G C+T G I L M C + +S C N
1
I T S R S F C T P G C V T G I L M C--P G N T I S C N G
27
48.5%
NC_015600.1 and 14 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
1
V T S K S L C T P G C I T G I L M
17
V T S K S L C T P G C T G I L M
1
V T S K S L C T P G C K T G I L M
17
48.5%
NZ_CP116604.1 and 2 others:
NZ_JAFFHI010000008.1 Lanthipeptides: JN541_RS08535_lanthipeptide NZ_JAFFHJ010000004.1 Lanthipeptides: JN542_RS06245_lanthipeptide
Lanthipeptides: PHA78_RS04905_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T Q N S C V S C N
28
+T S S L C T G C I T G +M + V S C N
1
I T S I S L C T A G C I T G R I M G C H K T P T V S C N
28
48.5%
NZ_GG667191.1 and 1 other:
NZ_GG667191.1 Lanthipeptides: HMPREF0298_RS11685_lanthipeptide
Lanthipeptides: HMPREF0298_RS11685_lanthipeptide
1
V T S K S L C T P G C I T G I L M C L T
20
+T S K S L C T P G C I T G +M C T
1
I T S K S L C T P G C I T G W M M C N T
20
48.5%
NZ_JAMDIB010000004.1:
Lanthipeptides: M5P35_RS04030_lanthipeptide
1
V T S K S L C T-P G C I T G I L M
17
V T S K S L C T P G C T G I L M
1
V T S K S L C T P P G C K T G I L M
18

#### MIBiG 4.0 matches for CQJ30_RS18315

38.2%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
V T S K S L C T P G C I T G I L M
17
+T S S L C T P G C T G L M
1
I T S I S L C T P G C K T G A L M
17

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.22 out of 20.97
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 21.55
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97
Confidence: medium
Additional weak hits (4):
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.53 out of 29.72
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.55 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.25 out of 30.11
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.46 out of 20.47
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

CQJ30_RS18315 - Class I
  Cleavage pHMM score: 17.50
  RODEO score: 29
  Monoisotopic mass: 3247.5 Da
  Molecular weight: 3249.9 Da
  Number of bridges: 7
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3268.0 Da N = 1
    3286.0 Da N = 2

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (3805143...3831522)
CQJ30_RS18310
  RRE type: Lanthipeptide_LanB_RRE
  Location: 153 - 241
  Score: 57.7

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A

NZ_CP023704.1 - Region 3 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 3,899,226 - 3,923,547 nt. (total: 24,322 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
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Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
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Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
CQJ30_RS18725: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase
CQJ30_RS18695: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

CQJ30_RS18715: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: deacetylase
CQJ30_RS18750: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Lyases: hydratase
CQJ30_RS18700: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
CQJ30_RS18685: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

CQJ30_RS18705: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

CQJ30_RS18720: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002193.2 |  | 0.56 | other (other) | phenguignardic acid | Aspergillus terreus NIH2624
BGC0001268.4 |  | 0.54 | NRPS, PKS | fusarin C | Fusarium fujikuroi
BGC0002284.3 |  | 0.54 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001160.5 |  | 0.52 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.52 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0002020.3 |  | 0.48 | NRPS, saccharide | photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc) | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000706.3 |  | 0.45 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0002405.2 |  | 0.45 | saccharide | mid-chain acyl sugars | Solanum lycopersicum
BGC0001103.5 |  | 0.45 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001137.5 |  | 0.44 | other (other) | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002193.2 |  | 0.56 | other (other) | phenguignardic acid | Aspergillus terreus NIH2624
BGC0001268.4 |  | 0.54 | NRPS, PKS | fusarin C | Fusarium fujikuroi
BGC0002284.3 |  | 0.54 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001160.5 |  | 0.52 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.52 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0002020.3 |  | 0.48 | NRPS, saccharide | photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc) | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000706.3 |  | 0.45 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0002405.2 |  | 0.45 | saccharide | mid-chain acyl sugars | Solanum lycopersicum
BGC0001103.5 |  | 0.45 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001137.5 |  | 0.44 | other (other) | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.69 out of 26.06
Confidence: medium
Additional weak hits (3):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.87 out of 29.51
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 25.75
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes