GCF_003030425.1 - 2 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP028285.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	975,423	996,304

NZ_CP028286.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	lanthipeptide-class-ii	79,672	102,653	High	cytolysin ClyLl/cytolysin ClyLs	ribosomal:RiPP:Lanthipeptide

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	975,423	996,304
Region 2.1	lanthipeptide-class-ii	79,672	102,653	High	cytolysin ClyLl/cytolysin ClyLs	ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:: NZ_CP028284.1 (Enterococcus faecalis); NZ_CP028283.1 (Enterococcus faecalis)

Compact view

NZ_CP028285.1 - Region 1 - terpene-precursor

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Location: 975,423 - 996,304 nt. (total: 20,882 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: peptidase

CEQ02_RS05710: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

CEQ02_RS05745: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

CEQ02_RS05745: PT_FPPS_like

Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78

Confidence: medium

Additional weak hits (1):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.47 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_CP028286.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 79,672 - 102,653 nt. (total: 22,982 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

CEQ02_RS16100: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

CEQ02_RS16110: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	1.00	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.53	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.50	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000502.5	0.45	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	1.00	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.53	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.50	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000502.5	0.45	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CEQ02_RS16110

CEQ02_RS16115

Leader:

MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS

Core:

GDVQAETTPACFTIGLGVGALFSAKFC

Core with dehydrations:

GDVQAEDhbDhbPACysFDhbIGLGVGALFDhaAKFCys

antiSMASH-DB 4.0 matches for CEQ02_RS16115

100.0%

NZ_AP026721.1and 35 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptideNZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide

Lanthipeptides: PO855_RS02215_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

85.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide

Lanthipeptides: BEH_RS02100_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQAETTP CFTIGLGVGAL SA C

GDVQAETTPVCFTIGLGVGALVSAAGC

77.8%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00410_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07260_lanthipeptide

Lanthipeptides: IKS_RS03655_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQAETTP CFT+GLGVG+L SA C

GDVQAETTPVCFTVGLGVGSLVSASVC

with 108 more sequence matches

Only the first 10 are displayed here.

74.1%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide

Lanthipeptides: IKS_RS03660_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQAETTP CFT+GLG+G+L SA C

GDVQAETTPVCFTVGLGIGSLVSASVC

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10230_lanthipeptide

GDVQAETTPAC-FTIGLGVGALFSAKFC

GDVQ ETTP C FTIG+G+GAL S K+C

GDVQPETTPICGFTIGIGIGALASVKWC

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10250_lanthipeptide

GDVQAETTPAC-FTIGLGVGALFSAKFC

GDVQ ETTP C FTIG+G+GAL S K+C

GDVQPETTPLCGFTIGIGIGALVSVKWC

70.0%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide

Lanthipeptides: COK11_RS25885_lanthipeptide

GDVQAETTPAC---FTIGLGVGALFSAKFC

GDV+ ETTPAC FTIGLG+GAL SA C

GDVKPETTPACLAGFTIGLGIGALASAAGC

66.7%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26125_lanthipeptide

GDVQAETTPAC---FTIGLGVGALFSAKFC

GDV+ ETTPAC FT+GLG+GAL SA C

GDVKPETTPACLAGFTVGLGIGALASAAGC

63.0%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08035_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQ ET+PAC TIG+G+G S FC

GDVQPETSPACVTIGIGIGIGISKLFC

59.3%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide

Lanthipeptides: OF830_RS26725_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

DVQ ETTPAC T L G +FS K+C

SDVQPETTPACVT-ALTTGIIFSIKWC

58.6%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide

Lanthipeptides: OF830_RS26730_lanthipeptide

GDVQAETTPAC---FTIGLGVGALFSAKFC

DVQ ETTPAC FTIG V +FS + C

SDVQPETTPACAVAFTIGATV--IFSVRNC

57.1%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11325_lanthipeptide

DVQAETTPAC-FTIGLGVGALFSAKFC

DVQ ETTP C F +G+G+GA+ SA C

DVQPETTPVCGFFVGVGIGAIISATAC

55.6%

NZ_JACSPU010000002.1:

Lanthipeptides: H9630_RS06775_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

DV ETTPAC G LFS KFC

SDVAPETTPAC-VAAFATGLLFSIKFC

MIBiG 4.0 matches for CEQ02_RS16115

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

TTPACFTIGLGVGAL-------FSAKFC

T PA + LG+ A+ SA FC

TDPAVTGLILGIVAIQAGVAVGVSAAFC

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

TPACFT

TP C T

TPGCKT

7.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

PACFTIG

PAC T+

PACHTLS

CEQ02_RS16120

Leader:

MENLSVVPSFEELSVEEMEAIQGS

Core:

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

Core with dehydrations:

GDVQAEDhbDhbPVCysAVAADhbAAADhaDhaAACysGWVGGGIFDhbGVDhbVVVDhaLKHCys

antiSMASH-DB 4.0 matches for CEQ02_RS16120

100.0%

NZ_AP026721.1and 34 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00880_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16120_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15480_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02735_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15930_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02745_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02750_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12760_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02150_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07625_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04340_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14515_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03420_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09015_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14935_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13260_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01390_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13035_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13280_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16405_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14540_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13380_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14600_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12620_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09835_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13355_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18035_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05645_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06455_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17465_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14360_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12995_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10435_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04385_lanthipeptide

Lanthipeptides: PO855_RS02210_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

93.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02045_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20135_lanthipeptide

Lanthipeptides: BEH_RS02105_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVVSLK C

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVSLKSC

90.9%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02050_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20130_lanthipeptide

Lanthipeptides: BEH_RS02110_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVV+LK C

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVTLKSC

with 107 more sequence matches

Only the first 10 are displayed here.

86.4%

NZ_JH791802.1and 5 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00420_lanthipeptideNZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00415_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07275_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07270_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07265_lanthipeptide

Lanthipeptides: IKS_RS30065_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AAT AASSAACGWVGGGI TGVTVV++LK C

GDVQAETTPVCAIAATTAASSAACGWVGGGIATGVTVVITLKSC

84.1%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26130_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AATAAASS C GGGI TGVTVVVSLKHC

GDVQAETTPVCAIAATAAASSGICAATGGGIATGVTVVVSLKHC

81.8%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide

Lanthipeptides: COK11_RS25880_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCAVAATAAASS C G GI TGVTVVVSLK C

GDVQAETTPVCAVAATAAASSGVCAATGAGIATGVTVVVSLKSC

77.3%

NZ_MIFM01000001.1and 1 other:

NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07280_lanthipeptide

Lanthipeptides: BHL22_RS00425_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCAV+ SSAACGWV GGI TGVTVVV+LK C

GDVQAETTPVCAVSVATMTSSAACGWVAGGIATGVTVVVTLKSC

72.7%

NZ_CP062165.1and 5 others:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17165_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide

Lanthipeptides: JNUCC31_RS17165_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQ ETTPVCAVAAT AASSA C VGGGI GVT+V+++K C

GDVQPETTPVCAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

72.7%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11330_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

DVQ ETTPVCAVAAT AASSA C VGGG+ GVTVV++LK C

ADVQPETTPVCAVAATVAASSATCAAVGGGVAVGVTVVLTLKTC

70.5%

NZ_KB946334.1and 1 other:

NZ_KB946334.1 Lanthipeptides: UC7_RS10235_lanthipeptide

Lanthipeptides: UC7_RS10245_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

GDVQAETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

68.2%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10240_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQ ETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

GDVQVETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

68.2%

NZ_LN831278.1:

Lanthipeptides: BN1360_RS08835_lanthipeptide

DVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

DVQ ETTP+CAVAAT AASSA C VGGGI GVT+V+++K C

DVQPETTPICAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

65.9%

NC_014098.1:

Lanthipeptides: BTUS_RS14190_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTP+C AAT ASSAAC VG GI GVT+V+++K C

GDVQAETTPICYTAATVTASSAACAGVGAGIVAGVTIVLTIKRC

allorf_098636_098806

Leader:

MFHKAKVKNIPVKNFFSDVRTVSRSLFRFQAVPFA

Core:

VCNVLFTVCYSTIASRKNKGI

Core with dehydrations:

VCysNVLFDhbVCysYDhaDhbIADhaRKNKGI

antiSMASH-DB 4.0 matches for allorf_098636_098806

100.0%

NZ_CP028286.1:

Lanthipeptides: allorf_098636_098806_lanthipeptide

VCNVLFTVCYSTIASRKNKGI

14.3%

NC_009328.1:

Lanthipeptides: allorf_2196525_2196659_lanthipeptide

NVLFTVCYSTIASRKNKGI

N++ + +STI+ + +G+

NIIANMLHSTISDKTRRGV

MIBiG 4.0 matches for allorf_098636_098806

14.7%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

CNVLFTVCYSTIASRK

CN+ C+ +I K

CNMKTATCHCSIHVSK

allorf_099257_099355

Leader:

MRKGRRMPTFFHARLNGVAVG

Core:

CGAHEKTDLLI

Core with dehydrations:

CysGAHEKDhbDLLI

antiSMASH-DB 4.0 matches for allorf_099257_099355

100.0%

NZ_CP028286.1:

Lanthipeptides: allorf_099257_099355_lanthipeptide

CGAHEKTDLLI

29.4%

NZ_CP070496.1:

Lanthipeptides: allorf_3770845_3770946_lanthipeptide

CGAHEKTDL

C A E+TD+

CSAQEETDI

17.1%

NZ_NEHJ01000011.1:

Lanthipeptides: allorf_106799_106939_lanthipeptide

GAHEKTDLLI

GAH+ DL+I

GAHQIQDLII

with 2 more sequence matches

14.9%

NZ_CP101655.1and 1 other:

NZ_JAHHZH010000008.1 Lanthipeptides: allorf_106741_106917_lanthipeptide

Lanthipeptides: allorf_2707176_2707352_lanthipeptide

CGAHEKTDLLI

CGAH+ DL+I

CGAHQIQDLII

14.0%

NZ_CP117877.1:

Lanthipeptides: PQ461_RS03070_lanthipeptide

GAHEKTDL

GAHE T+L

GAHENTEL

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.29 out of 29.38

Confidence: medium

Additional weak hits (4):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.92 out of 20.01

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.08 out of 29.72

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.18 out of 19.52

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

CEQ02_RS16115 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 2630.3 Da

Molecular weight: 2632.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2650.0 Da N = 1; 2668.0 Da N = 2

CEQ02_RS16120 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 4017.0 Da

Molecular weight: 4019.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4037.6 Da N = 1; 4055.6 Da N = 2; 4073.6 Da N = 3; 4091.6 Da N = 4; 4109.6 Da N = 5

allorf_098636_098806 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 2243.2 Da

Molecular weight: 2244.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2262.7 Da N = 1; 2280.7 Da N = 2

allorf_099257_099355 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 1180.6 Da

Molecular weight: 1181.4 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator