LOCUS       NZ_CP028286            22982 bp    DNA     circular CON 02-DEC-2024
DEFINITION  Enterococcus faecalis strain FDAARGOS_324 plasmid unnamed1, complete
            sequence.
ACCESSION   NZ_CP028286
VERSION     NZ_CP028286.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Enterococcaceae; Enterococcus.
REFERENCE   1  (bases 1 to 103690)
  AUTHORS   Campos,J., Goldberg,B., Tallon,L., Sadzewicz,L., Sengamalay,N.,
            Ott,S., Godinez,A., Nagaraj,S., Vavikolanu,K., Vyas,G., Nadendla,S.,
            Aluvathingal,J., Geyer,C., Nandy,P., Hobson,J. and Sichtig,H.
  TITLE     FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
            Supporting development and validation of Infectious Disease Dx tests
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 103690)
  AUTHORS   Campos,J., Goldberg,B., Tallon,L., Sadzewicz,L., Sengamalay,N.,
            Ott,S., Godinez,A., Nagaraj,S., Vavikolanu,K., Vyas,G., Nadendla,S.,
            Aluvathingal,J., Geyer,C., Nandy,P., Hobson,J. and Sichtig,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-MAR-2018) Center for Devices and Radiological Health,
            US Food and Drug Administration, 10903 New Hampshire Avenue, Silver
            Spring, MD 20993-0002, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT v. 2.3.0, HGAP v. 3.0
            Genome Coverage                   :: 15.602692881523x
            Sequencing Technology             :: PacBio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003030425.1-RS_2024_12_02
            Annotation Date                   :: 12/02/2024 04:05:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,088
            CDSs (total)                      :: 3,014
            Genes (coding)                    :: 2,921
            CDSs (with protein)               :: 2,921
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 93
            CDSs (without protein)            :: 93
            Pseudo Genes (ambiguous residues) :: 0 of 93
            Pseudo Genes (frameshifted)       :: 46 of 93
            Pseudo Genes (incomplete)         :: 41 of 93
            Pseudo Genes (internal stop)      :: 23 of 93
            Pseudo Genes (multiple problems)  :: 16 of 93
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:01:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 79671
            Orig. end                         :: 102653
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP028286.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22982
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22982
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22982
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12982](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12982)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            678..2720
                     /locus_tag="CEQ02_RS16080"
                     /old_locus_tag="CEQ02_16065"
     CDS             678..2720
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002367824.1"
                     /locus_tag="CEQ02_RS16080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16065"
                     /product="histidinol-phosphatase"
                     /protein_id="WP_002367824.1"
                     /transl_table=11
                     /translation="MKKIDLHIHTISTVSDSKKFLFSMEKLKEYVSTRNLDAIAITNHN
                     IFDIDQFDQIQQELTIPVFPGVEVDLENGHILVISDNSLFNIQDFSEKCKKLGSYIKDQ
                     NSTLTLDEFYRVFPRKELKKYLLIPHYMKSPEISDSVIKDLSQHSKITTGETSSVRKFV
                     ELLNKEDDLIPVFFSDQRMSEDLVNHSMQQTYINVSEINFAALKYTLSDKSKVALSLKE
                     GKDLFNLTEKVVASTGLNVLIGERSSGKTHLLNEIAQSTSNTKYIRQFELVERSDDESK
                     ENFNRQLLRDESLFTENFLKEFKDILTLVLPIDPKQSESNVNKYLRSLIKNAESTEKKD
                     SFAKAKLFSEIPYKPKSLDTLDELIKSIQILIDNQEYSSIIFEELPQESLIKLLNRLVD
                     EYRKIYLSNFIKEKSNSLIADIQGALQLKTRIQRVSDIDFSDIAKETLMINEFNNITKE
                     LQKDKILDETEIYDFTIRKSKRPFKGAQEVLNIIKKQTSFIEVFKFYDHPFDYLQALKN
                     KDVLEHADFVKYFVKIQIEILNKDLNPVSGGQRAEYNFLRKIEDSLKYDLLLIDEPESS
                     FDNMFLNNKINTVLQEISKHIPVFVSTHNNTIGASIKPDFILHTQRTLVLDEPVFNIYY
                     GYPTDKKLYASNGLSVNNLSVQLNCLEAGEQTYKTRRDTYEILEN"
     misc_feature    complement(694..707)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.92"
                     /tool="antismash"
     gene            2701..3003
                     /locus_tag="CEQ02_RS16085"
                     /old_locus_tag="CEQ02_16070"
     CDS             2701..3003
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002367825.1"
                     /locus_tag="CEQ02_RS16085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16070"
                     /product="hypothetical protein"
                     /protein_id="WP_002367825.1"
                     /transl_table=11
                     /translation="MKYLKIDDNKGYFLRENAWVPIDQIIKEDIFELISLAVLPKDGTT
                     FEMDEFSEEKLQHGVHKIIYKSIHDKLFELIKDKENIQDSVNQQFASALQKYSTN"
     gene            complement(3434..5095)
                     /locus_tag="CEQ02_RS16090"
                     /old_locus_tag="CEQ02_16075"
     CDS             complement(3434..5095)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002404179.1"
                     /locus_tag="CEQ02_RS16090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16075"
                     /product="DNA/RNA helicase domain-containing protein"
                     /protein_id="WP_033602817.1"
                     /transl_table=11
                     /translation="MDIMNTTKDDQLINSMLRLCDDSIVHNPEQFFRKKELQNLYQFSE
                     KLLPMLTNIPKADNYFIGYSVSIGITRQFDVLRFSTKKVVNIELKDCMPSDGLEAIRRQ
                     LIKNQLFLKVLGKEIISCTYIADTETIYMLTADDELSTIEVEKLGRLIPMDSLDINELE
                     SQQLTNFIISPYSETDRFVSHTYFLTDQQETKKNQIMQSNSKKIGIIGRAGTGKSILLF
                     DLAQTWVKKGKKVLVVFVGQLNNYSSISEKFGFEITPIRFMDSEKILEGEYDIVLVDEA
                     QRLSTEQYSFFTNIETKIILSVDHLQIFHPSENDRNIEGEIEKNSNFEVVNLGKKVRTD
                     KELADFINKLMDLSARNISPHDYNNISINYFESSQVAKEFIDDKVIHDGWNSIEFTEYR
                     TKSAGRLTKSMISRHSLSTHEVVGREYDKVIIVIDSLVRRSDDGKLIYMRNDRYPYLEM
                     SLLLEGLTRVRSKLMLVVVNNADMYVDIQRNLLSWKNDQLAGIKTYDKELNYDSWDNAI
                     ENLEIPVNGIMYKASKVEYIEKTRKVKVSYFAVESI"
     gene            complement(5626..6609)
                     /locus_tag="CEQ02_RS16095"
                     /old_locus_tag="CEQ02_16080"
     CDS             complement(5626..6609)
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M50"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358185.1"
                     /locus_tag="CEQ02_RS16095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16080"
                     /product="site-2 protease family protein"
                     /protein_id="WP_010775173.1"
                     /sec_met_domain="Peptidase_M50 (E-value: 1.4e-08, bitscore:
                     27.2, seeds: 56, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFISPMIFTLLLVIFTFVFELNLVSTAYFALLLSIFVHELGHLA
                     FGLFNKVRPESLIFGFIKFSWENQFKIRLNTQWGFFGGLFRYKPTTFNNKKILRLLTGG
                     PIFSLFFTLTFFVKIDFFQYFSLFNFSIFLITAVPFNFNGFMNDGYNIYKLVTKDYIFE
                     MYYIVSNSLLNKYNQSTFLNTTEVCKIIKKNKELPLYVLNTFLLYVIYEYLIDKNNRKL
                     KLIYPILSKEDKILNNKSYLQNFYLANLYMIEYILSVDNKQTFKKINLKILDSISRSRI
                     RYLNFKCSKSDDDEISQSMTEFSNIIKNYSDQMSTMIIAEKQWVQN"
     gene            complement(6610..7848)
                     /locus_tag="CEQ02_RS16100"
                     /old_locus_tag="CEQ02_16085"
     CDS             complement(6610..7848)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358184.1"
                     /locus_tag="CEQ02_RS16100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16085"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_010775172.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 4.1e-37, bitscore:
                     120.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRGFTYILISYIFLTLGTTGYASDLSNNISFFIDNSQTTAIEE
                     IESELSSEKVDYIQEIGLVSFKNLDDSDRKFIGKYFNVSEGKKLPDFKPEEVNSSILNI
                     NILNKDFKSFNWPYKKILSHIDPVKEQLGKDITIALIDSGIDRLHPNLQDNNLRLKNYV
                     NDIELDEYGHGTQVAGVIDTIAPRVNLNSYKVMDGTDGNSINMLKAIVDATNDQVDIIN
                     VSLGSYKNMEIDDERFTVEAFRKVVNYARKNNILIVASAGNESRDISTGNEKHIPGGLE
                     SVITVGATKKSGDIADYSNYGSNVSIYGPAGGYGDNYKITGQIDAREMMMTYYPTSLVS
                     PLGKAADFPDGYTLSFGTSLATPEVSAALAAIMSKNVDNSKDSNEVLNTLFENADSFID
                     KNSMLKYKEVRIK"
     gene            complement(7845..9989)
                     /locus_tag="CEQ02_RS16105"
                     /old_locus_tag="CEQ02_16090"
     CDS             complement(7845..9989)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002415198.1"
                     /locus_tag="CEQ02_RS16105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16090"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_002365931.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.8e-43, bitscore:
                     139.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLKYVAQGEHSECALACITMLLNYYGNQSTLVELREKYGVPKG
                     GLTIKNIRTVFDEYGFDVSTFKSSFSNYLDLPTPVISYWNNQHFVVIEKIKKKKVLILD
                     PASNKRWIDISEFKKNFSNILIYAHKKKTKKEGKRKQFFLKSFIFTKFKRYFFSLIILS
                     FVSQLLLLLIPIATKYSIDNIRSFQEIPTYVLLLILTSFFSVLYVVQYLKSSVVAEFQY
                     EFDFKLMFSYIDKLFSMPLMYFSNRSTGELVFRANLNIYIRQILSQKVITTLIDSLFLG
                     IYLFLMVNYSILLTIIALVLISLIAFLSIINSHTIKRFVDKEIMEQGNVQRIITEAIEG
                     IETIKSANAEKSFLLNWKNMFTSQLLITKNKNRYIAIFGILPEIIQSVMPALFLIIGIK
                     LIINNSLSLGSLIGFVSIVTMVMKPILSLVSSYNDFLLLNVYFQKLSEVLTYEEKNDFN
                     NKKGNVGKEEFIYRVNNVYYTISVFEKNILNGISFDIRKGDKVAIVGRSGSGKSTLLKL
                     LAGLLQPSNGEILYEGYPLSNNSNNRRNIFYVNQNAHIFNETIEKNISLEFKPNSSINE
                     KKRLKESMSKSKMDEVLLGIPQYEKTIVSENGSNFSGGQRQKIALARAFYSNVNTLLLD
                     EPTSAMDNISEFEVFSNLLDEKRTVITVAHRISTVKNFDKIILMDNGEIVCIGKHEDLI
                     ENSELYRSLYYKKQQFGGTK"
     gene            complement(10001..12982)
                     /locus_tag="CEQ02_RS16110"
                     /old_locus_tag="CEQ02_16095"
     CDS             complement(10001..12982)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002368286.1"
                     /locus_tag="CEQ02_RS16110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16095"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_002365930.1"
                     /sec_met_domain="DUF4135 (E-value: 1.4e-94, bitscore:
                     310.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.6e-51, bitscore:
                     168.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDNLINVLSINERCFLLKQSGNEKYDIKNLQAWKERKSVLKQDD
                     LDYLIKYKYESLDNFGLGITPIENFPDKEVAIQYIKDQSWYIFFESILDSYNDSEEQLL
                     EVDASYPFRYFLQYARLFLLDLNSELNICTKEFIINLLENLTQELIHLTSKTLVLDLHT
                     FKKNEPLKGNDSSKRFIYYLKKRFNSKKDIIAFYTCYPELMRITVVRMRYFLDNTKQML
                     IRVTEDLPSIQNCFNIQSSELNSISESQGDSHSRGKTVSTLTFSDGKKIVYKPKINSEN
                     KLRDFFEFLNKELEADIYIVKKVTRNTYFYEEYIDNIEINNIEEVKKYYERYGKLIGIA
                     FLFNVTDLHYENIIAHGEYPVIIDNETFFQQNIPIEFGNSATVDAKYKYLDSIMVTGLV
                     PYLAMKDKSDSKDEGVNLSALNFKEQSVPFKILKIKNTFTDEMRFEYQTHIMDTAKNTP
                     IMNNEKISFISYEKYIVTGMKSILMKAKDSKKKILAYINNNLQNLIVRNVIRPTQRYAD
                     MLEFSYHPNCFSNAIEREKVLHNMWAYPYKNKKVVHYEFSDLIDGDIPIFYNNISKTSL
                     IASDGCLVEDFYQESALNRCLNKINDLCDEDISIQTVWLEIALNIYNPYKYINDLKNQN
                     SNKYIYTGLELNSKIIQACQKIEKKIFKRAIFNKKTNTVNWIDIKLDQDWNVGILNNNM
                     YDGLPGIFIFYVALKYITKNHKYDYVIECIKNSIYTIPSEDILSAFFGKGSLIYPLLVD
                     YRLNNDINSLNVAVEIADMLIEKKPINNGELKNDWIHGHNSIIKVLLLLSEITEDEKYR
                     KFSLEIFEKLSEEPYFNFRGFGHGIYSYVHLLSKFNRIDKANSLLHKIKESYFEEEPKN
                     NSWCKGTVGELLATIELYDDNISNIDINKTIEYKNKDCLCHGNAGTLEGLIQLAKKDPG
                     TYQYKKNKLISYMLNDFEKNNTLKVAGSEYLESLGFFVGISGVGYELLRNLDSEIPNAL
                     LFEL"
     gene            complement(13043..13234)
                     /gene="cylL-S"
                     /locus_tag="CEQ02_RS16115"
                     /old_locus_tag="CEQ02_16100"
     CDS             complement(13043..13234)
                     /codon_start=1
                     /gene="cylL-S"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358181.1"
                     /locus_tag="CEQ02_RS16115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16100"
                     /product="lanthipeptide cytolysin subunit CylL-S"
                     /protein_id="WP_002358181.1"
                     /transl_table=11
                     /translation="MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGSGDVQAETTP
                     ACFTIGLGVGALFSAKFC"
     CDS_motif       complement(13127..13234)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS"
                     /locus_tag="CEQ02_RS16115_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13043..13126)
                     /prepeptide="core"
                     /locus_tag="CEQ02_RS16115_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="2632.0"
                     /monoisotopic_mass="2630.3"
                     /core_sequence="GDVQAETTPACFTIGLGVGALFSAKFC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS"
                     /leader_location="[13126:13234](-)"
                     /alternative_weights="2650.0"
                     /alternative_weights="2668.0"
     gene            complement(13268..13474)
                     /gene="cylL-L"
                     /locus_tag="CEQ02_RS16120"
                     /old_locus_tag="CEQ02_16105"
     CDS             complement(13268..13474)
                     /codon_start=1
                     /gene="cylL-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358485.1"
                     /locus_tag="CEQ02_RS16120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16105"
                     /product="lanthipeptide cytolysin subunit CylL-L"
                     /protein_id="WP_002358485.1"
                     /transl_table=11
                     /translation="MENLSVVPSFEELSVEEMEAIQGSGDVQAETTPVCAVAATAAASS
                     AACGWVGGGIFTGVTVVVSLKHC"
     CDS_motif       complement(13403..13474)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MENLSVVPSFEELSVEEMEAIQGS"
                     /locus_tag="CEQ02_RS16120_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13268..13402)
                     /prepeptide="core"
                     /locus_tag="CEQ02_RS16120_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="2.00"
                     /molecular_weight="4019.5"
                     /monoisotopic_mass="4017.0"
                     /core_sequence="GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKH
                     C"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENLSVVPSFEELSVEEMEAIQGS"
                     /leader_location="[13402:13474](-)"
                     /alternative_weights="4037.6"
                     /alternative_weights="4055.6"
                     /alternative_weights="4073.6"
                     /alternative_weights="4091.6"
                     /alternative_weights="4109.6"
     misc_feature    13877..13892
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.29"
                     /tool="antismash"
     gene            13878..14078
                     /gene="cylR2"
                     /locus_tag="CEQ02_RS16130"
                     /old_locus_tag="CEQ02_16115"
     CDS             13878..14078
                     /codon_start=1
                     /gene="cylR2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002370931.1"
                     /locus_tag="CEQ02_RS16130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16115"
                     /product="cytolysin regulator CylR2"
                     /protein_id="WP_002358483.1"
                     /transl_table=11
                     /translation="MIINNLKLIREKKKISQSELAALLEVSRQTINGIEKNKYNPSLQL
                     ALKIAYYLNTPLEDIFQWQPE"
     gene            complement(14524..15837)
                     /locus_tag="CEQ02_RS16135"
                     /old_locus_tag="CEQ02_16120"
     CDS             complement(14524..15837)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002383787.1"
                     /locus_tag="CEQ02_RS16135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16120"
                     /product="hypothetical protein"
                     /protein_id="WP_033785406.1"
                     /transl_table=11
                     /translation="MEDRSDIVINKVEKRDILILSSFVFVVMLIYNFGIKQMEFGDDAF
                     FLKQFTHDFQSNYYEFLEFRYNEWTSRLVIEIALTQAVQHVFLWRVLNAIAMSIVAIVP
                     ALLINSDNRRRGLIIGTGMSLLIPASMINNAGWIATTTNYVWVMAAALLSIWPIMNYIR
                     GKSVNWLSFILSLVFLIYATNQEQMVVIMLVSLLVLAGILYLSKMNILITLPHIAIVIA
                     SLVFILTCKGNAARNVQETKQWLPNFSSYSIFDKLQIGYSSTLKALFFEWSPLMLAFVL
                     LILTAGLVKNGTLVKKMISGIPLLTYLICTRFNTIIDQTYDIVSGKTYMSLVVLLTGLV
                     FLYVIGIFGASNNPLEFLSVIFLLILGVGSRIMMGFSPTIWVSGSRTYYFTYVLIMMSG
                     VYLISQLPENNQSRTFKVLFGYFLVLALLLIMMYTKIL"
     gene            complement(15827..15958)
                     /locus_tag="CEQ02_RS16735"
     CDS             complement(15827..15958)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000159353.1"
                     /locus_tag="CEQ02_RS16735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000159353.1"
                     /transl_table=11
                     /translation="MTKEEKIILIVRNSDFTYEELEKLPMSSIDSIYKAHVLEKNGG"
     gene            complement(15961..16824)
                     /locus_tag="CEQ02_RS16140"
                     /old_locus_tag="CEQ02_16125"
     CDS             complement(15961..16824)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000865436.1"
                     /locus_tag="CEQ02_RS16140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16125"
                     /product="DNA/RNA non-specific endonuclease"
                     /protein_id="WP_000865436.1"
                     /transl_table=11
                     /translation="MKVKRKKQPYWLGSLLSLVIIGFGLLNHLDLSEQLSSFLSNDIFQ
                     EVAKSDKKSLTKKPRNVKTKKSTSAPYDQQQYNQLANLDFQSGGKAAIEVNNGQSSLDI
                     ATWKENKVIYGDLDSLNRTTFVTAYLDRKNLGRSEGRERQVWQPTGWHQKQIDGDPIVN
                     RGHLLAYTSSFNFDIDGNFKIGENGSQDNPKNLATQTAFSNQKVQTHYEKLVRDAQKLK
                     GNKVIYQIVTVFRGKELMPRGYWLQAIDSAGTLNFNVYEYNVQPNVVFNYEEGTSQIDR
                     TMKVRE"
     gene            complement(16814..17257)
                     /locus_tag="CEQ02_RS16145"
                     /old_locus_tag="CEQ02_16130"
     CDS             complement(16814..17257)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001209505.1"
                     /locus_tag="CEQ02_RS16145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16130"
                     /product="hypothetical protein"
                     /protein_id="WP_001209505.1"
                     /transl_table=11
                     /translation="MREVTAQQLLTEFSIIEKMAQSDAIKQRFCLDNYLAEDVKSAINE
                     LNSLYPAYHFEYQEVFGGFGHDLVVTDIAQKVTYDRIPKTRTYGELFQTLAKVYGIHSS
                     AKFHHKPTDRLTEEEFQETIKFYENFDIDTLFSQDDEDKYDES"
     gene            complement(17254..17397)
                     /locus_tag="CEQ02_RS16315"
     CDS             complement(17254..17397)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000066155.1"
                     /locus_tag="CEQ02_RS16315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000066155.1"
                     /transl_table=11
                     /translation="MSNKELSKKYQESLKQRREKQTKRERALEGTVIAPLTDKNNRKDK
                     NK"
     gene            complement(17471..18184)
                     /locus_tag="CEQ02_RS16150"
                     /old_locus_tag="CEQ02_16135"
     CDS             complement(17471..18184)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CEQ02_RS16150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CEQ02_16135"
                     /product="hypothetical protein"
                     /protein_id="WP_225850086.1"
                     /transl_table=11
                     /translation="MTDTFFSQAEYLIEWHLKGVDITGFKDLHEVIQQLERELAEQTLA
                     EINQHYNYYYTLEGKYLADLSDWKITTLKNEVRKKLLDGQTTFIMDHSFVQYECADSEI
                     LDLLTEKQATQSRLVKKYLEKNARMLSEHLQKLQFQQQYAKELAENKQFQKEKEIIQAV
                     QNKGMKTITVTYQISDKELTFKMRNIIDSSRDYFSSYDITNKKERDAYDTLTREAIDLQ
                     KIKQISYGRKVLYAE"
     gene            complement(18546..18743)
                     /locus_tag="CEQ02_RS16155"
                     /old_locus_tag="CEQ02_16140"
     CDS             complement(18546..18743)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001031355.1"
                     /locus_tag="CEQ02_RS16155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16140"
                     /product="hypothetical protein"
                     /protein_id="WP_001031355.1"
                     /transl_table=11
                     /translation="MNKEQAFQTLDSLVYAMEKLENESIRSEDNEELEQMLALMNRDWH
                     ELYTIYGKAWEEYRKNALEK"
     CDS             complement(18965..19135)
                     /gene="allorf_098636_098806"
                     /locus_tag="allorf_098636_098806"
                     /protein_id="allorf_098636_098806"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MFHKAKVKNIPVKNFFSDVRTVSRSLFRFQAVPFAVCNVLFTVCY
                     STIASRKNKGI"
     CDS_motif       complement(19031..19135)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MFHKAKVKNIPVKNFFSDVRTVSRSLFRFQAVPFA"
                     /locus_tag="allorf_098636_098806_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18965..19030)
                     /prepeptide="core"
                     /locus_tag="allorf_098636_098806_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.40"
                     /molecular_weight="2244.7"
                     /monoisotopic_mass="2243.2"
                     /core_sequence="VCNVLFTVCYSTIASRKNKGI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFHKAKVKNIPVKNFFSDVRTVSRSLFRFQAVPFA"
                     /leader_location="[19030:19135](-)"
                     /alternative_weights="2262.7"
                     /alternative_weights="2280.7"
     gene            19311..19457
                     /locus_tag="CEQ02_RS16855"
     CDS             19311..19457
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010746377.1"
                     /locus_tag="CEQ02_RS16855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative holin-like toxin"
                     /protein_id="WP_141435800.1"
                     /transl_table=11
                     /translation="MNVLPKSIERRSLLSVSESLQLMLAFGGFTLTLITTIVAILNYKD
                     KKK"
     CDS             19586..19684
                     /gene="allorf_099257_099355"
                     /locus_tag="allorf_099257_099355"
                     /protein_id="allorf_099257_099355"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRKGRRMPTFFHARLNGVAVGCGAHEKTDLLI"
     CDS_motif       19586..19648
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRKGRRMPTFFHARLNGVAVG"
                     /locus_tag="allorf_099257_099355_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       19649..19684
                     /prepeptide="core"
                     /locus_tag="allorf_099257_099355_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.40"
                     /molecular_weight="1181.4"
                     /monoisotopic_mass="1180.6"
                     /core_sequence="CGAHEKTDLLI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRKGRRMPTFFHARLNGVAVG"
                     /leader_location="[19585:19648](+)"
     gene            complement(19749..20146)
                     /locus_tag="CEQ02_RS16860"
                     /old_locus_tag="CEQ02_16155"
                     /pseudo=""
     CDS             complement(19749..20146)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012651.5"
                     /locus_tag="CEQ02_RS16860"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16155"
                     /product="single-stranded DNA-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIQLSAVGRLTKGAELRTTTNGKSVANVTLACKRKRPDTNGNVPT
                     TFIQCVLWGKPPKSLQNTRKKAH"
     misc_feature    20183..20199
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.08"
                     /tool="antismash"
     gene            complement(20283..21604)
                     /locus_tag="CEQ02_RS16175"
                     /old_locus_tag="CEQ02_16160"
                     /pseudo=""
     CDS             complement(20283..21604)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002395040.1"
                     /locus_tag="CEQ02_RS16175"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16160"
                     /product="PcfJ domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRMNKKTPKPLTHPKPFLTGVLHKYQRMNGKTKRRQFCEFSQELP
                     HHKKRLTKYSRLSFPTKFYSFGIILVRAKRIEIQTHSYWQTITDGTETLIYEPSNLERF
                     SNDTHVKAHYENGHWHEGLLANYGYMSSAYTNTVFYQITGKKN"
     gene            complement(21595..22369)
                     /locus_tag="CEQ02_RS16180"
                     /old_locus_tag="CEQ02_16165"
                     /pseudo=""
     CDS             complement(21595..22369)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002398548.1"
                     /locus_tag="CEQ02_RS16180"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16165"
                     /product="Cas9 inhibitor AcrIIA9 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDFQNIQTVKELRYALKQYKQTLATTIFDDTQGYISVAFKKEVIE
                     KDGKNVQFLCFYPNYEVALYPVETLLAYLEKLPEQAIVTIKDHDGNYSSLFLTIDETID
                     QGNNYQWLVISDKNSYERFFFTAQESTQEQAFEKMLKELETDHDSTLEVVHNWLCRKQT
                     KRFF"
     gene            complement(22528..22794)
                     /locus_tag="CEQ02_RS16185"
                     /old_locus_tag="CEQ02_16170"
     CDS             complement(22528..22794)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001245899.1"
                     /locus_tag="CEQ02_RS16185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CEQ02_16170"
                     /product="hypothetical protein"
                     /protein_id="WP_001245899.1"
                     /transl_table=11
                     /translation="MRNRIEELKEQARTELNEWGLIIDGCFEGDFETWIGCYARPKDKP
                     TALDPINEEEAKEQAKYAVNGFPQDFTEWYEWEINNGKLKNLL"
     misc_feature    22857..22869
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     misc_feature    complement(22887..22902)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.18"
                     /tool="antismash"
ORIGIN
        1 tatccattgt tatattttct tgaagactat gaaaactaac acctcgttca ttcaaacgat
       61 tgacgattga aatcaaatct tccatatttc tgcctagacg atctaaacgc caaacgacaa
      121 gtgtatctcc agatcgaaca aaatcaatgg ctgtttctaa tcctggtcga ttactttttg
      181 caccactcat atgatctgta aaaatttttt cgcagccaaa tttatttaag ctatcttctt
      241 gtaaatctaa attttgtaaa ccagtagaga cccgggcgta tcctattttc aaaaaaatca
      301 ctcctttaca aaatctattg taacataact ttaaataact agtataattg aacatagatt
      361 ttgatatgag tttatggaca caaaaagaag ttaaaaattt aaaaactaga taaaaaaaca
      421 ctgtgtacag aaacggctga ttttctggac aattcatctc aatcacccta atgtatcatt
      481 tgggtttaga aagtatcaaa gaggtaaaat cacgaggcag tatctatatt gccaaatcct
      541 tattatagaa tttgataata cttagtttat gttctaaaaa agttcttcga tttttttaca
      601 aaaagaaaaa gcgaagaact tgtttttaag atataatagt ggtaaatata tctactatta
      661 ggaaggagaa aaacggtttg aaaaaaatag atttgcatat ccatacgatt agcactgtca
      721 gtgattctaa aaaattttta ttctccatgg aaaaattaaa agaatatgta tcaaccagga
      781 accttgatgc catagctatt acaaatcata atatttttga tattgatcaa tttgatcaaa
      841 tccaacaaga attaactatt cctgttttcc ctggtgttga ggttgatctt gaaaatggtc
      901 atattttagt catatcagat aattctctgt tcaatatcca agatttttca gaaaaatgta
      961 aaaaactagg ttcctatatt aaagatcaaa actcgacctt aacattggac gaattttata
     1021 gagtttttcc aagaaaagaa ctaaaaaaat atctattgat tcctcattat atgaaatcac
     1081 cagaaatctc tgactctgtg attaaggatt tgtctcaaca ttctaaaatt actaccggag
     1141 aaacaagttc tgttcgaaaa tttgtggaac ttttaaacaa agaagacgac cttataccag
     1201 ttttttttag tgatcagcgt atgtctgaag accttgtaaa tcatagtatg cagcaaacat
     1261 acatcaatgt ctctgaaata aattttgccg ctttaaaata tactttatct gacaaatcaa
     1321 aggttgcctt gtctttgaaa gagggaaagg atctttttaa cttaaccgaa aaagtcgtag
     1381 cttctacagg attaaatgtt ttgataggtg aacgttcatc aggtaagacc catttgttaa
     1441 atgagatagc tcaatcaaca agtaatacaa agtatatcag acaatttgag ttagttgaac
     1501 gaagtgacga tgaatcaaaa gagaacttta atcgacaact cttaagagat gaaagtctat
     1561 ttacagaaaa cttcctaaaa gaatttaagg atattttaac acttgttctt cctattgatc
     1621 cgaaacaatc agaatctaat gtgaataaat atttacgctc attgattaag aacgccgaaa
     1681 gcactgaaaa aaaggattct tttgctaaag ctaaattatt ctcagagata ccttataaac
     1741 cgaaatcttt ggacacgctg gacgaattga taaaatctat ccaaattctt attgataatc
     1801 aagaatattc gagtatcatt tttgaagaat tacctcagga gtcattgata aaactcctaa
     1861 atcgattagt cgatgaatat agaaaaatct acctgagtaa ttttattaag gagaagtcaa
     1921 attcattaat tgcagatata caaggggctt tacaactcaa aactaggatt caacgagtat
     1981 ctgatataga tttttccgat attgcaaagg aaactctaat gatcaatgag ttcaataaca
     2041 taaccaaaga actacaaaaa gataagatct tggacgaaac tgaaatttac gattttacaa
     2101 tcagaaaatc caaacgacct tttaaaggtg cccaagaagt gctgaacatt attaaaaagc
     2161 aaacttcctt tattgaagtc tttaaatttt atgatcaccc atttgactac ctacaagctt
     2221 taaaaaacaa agatgtttta gaacatgctg attttgtaaa atactttgtt aaaatacaaa
     2281 ttgagatatt aaacaaagat ttgaatcccg tttctggggg gcaacgagca gaatataatt
     2341 ttctcagaaa aatagaagat tcactcaaat acgatctact ccttattgat gaacctgagt
     2401 cttcttttga taatatgttt ttaaacaaca aaataaatac agttctacaa gaaatctcta
     2461 aacatattcc tgtttttgtc tcaacgcata ataatacaat tggcgcatct ataaaacctg
     2521 attttatttt gcatactcaa agaactttag tacttgacga gcccgtattt aacatctatt
     2581 acggctatcc tactgataaa aaattgtacg catctaacgg tctttccgta aacaatctgt
     2641 ctgtacaatt gaattgccta gaagcaggcg aacaaacata caaaacaagg agagatactt
     2701 atgaaatact tgaaaattga tgacaataaa ggttactttt taagagaaaa tgcttgggtg
     2761 ccaattgatc aaatcatcaa agaagatatc ttcgaattaa tttctctagc cgttttaccc
     2821 aaagacggaa ctacatttga aatggatgaa ttttcagaag aaaagctaca acatggagtt
     2881 cataaaatta tttacaagag tattcatgat aaactatttg aactaattaa agataaagaa
     2941 aatatccaag atagtgtaaa tcaacaattt gcgtctgcat tacaaaagta ttcgacgaac
     3001 taattgattc ataaaatgat taaatctctt ctggaagttg atataattaa atatctgcag
     3061 gtaccagtaa aaagcttaat attcatgaag cacataaata acgagaacct aaacattaga
     3121 ctaaaaatct aatttaaaag ttgagattag tatggtaacc cagataaaaa taaaggtaaa
     3181 ttaagtaacc gaacctttga aacaacaaga aaaaaatcac tcaaaaatag ttgagtgatt
     3241 tttttcttgt atacagattt atagtttgtg ccaattaaaa attaaatttt ttgtcattta
     3301 aaaataaaaa tgacatccaa gtatagcacg aaaaaataaa gaggtcaaaa acttaaaagt
     3361 ttttgacctc tttgctgtta gttgaataag acacaactag ctatagtaaa ataactaatt
     3421 taattaataa tctttaaatt gattccactg cgaaatatga gacttttacc tttcttgttt
     3481 tttctatata ttcaacttta gaagctttat acataatacc attaacagga atttctaaat
     3541 tttcaatcgc attatcccag ctatcataat ttagctcttt gtcgtatgtt ttaattccag
     3601 ctaattgatc atttttccag gacagtagat ttctttgtat atcaacatac atgtcagcat
     3661 tgttaaccac tactaacatc aacttacttc taacacgtgt tagtccttct aataataagc
     3721 tcatttcaag gtacggatac cgatcatttc tcatataaat taacttacca tcgtcactac
     3781 gtctaactaa actatctatg acaataataa ccttatcata ttctcttcca acgacctcat
     3841 gagtagaaag agaatgccta gaaatcatag attttgtcaa tctcccagca gatttagttc
     3901 tatattcagt aaattctatt gaattccagc cgtcatggat gactttgtca tcaataaatt
     3961 ctttagcaac ctgacttgat tcaaaatagt tgatacttat attattgtaa tcatggggtg
     4021 aaatatttct ggcagacaag tccattaact tatttataaa gtcagctaat tccttgtctg
     4081 tacgtacttt tttacctaaa tttacaactt caaaatttga atttttctct atttcacctt
     4141 caatatttct atcattttct gaagggtgga atatttgtaa atgatctaca gataaaatga
     4201 ttttggtttc tatatttgta aaaaaactat attgttctgt acttaacctc tgcgcctcat
     4261 caaccagtac aatatcgtat tcaccctcaa gtattttttc gctgtccata aaacggattg
     4321 gagtaatttc aaatccaaac ttttcactta tcgaactata gttatttaat tgcccaacaa
     4381 atactactaa aacttttttg cctttcttca cccatgtctg agctaaatca aataataaaa
     4441 tagatttccc tgttccagct cttccaataa ttccaatttt tttggagtta gactgcatta
     4501 tttgattttt tttagtttct tgctgatcag taaggaaata ggtgtgactt acaaacctat
     4561 ctgtctctga gtatggtgag ataataaaat tagtcagctg ttgagattct aattcgttta
     4621 tgtctaaact gtccataggg attaatctgc ctaatttttc aacctcaatt gtacttaatt
     4681 catcatcagc tgttaacatg taaattgtct ctgtgtcagc tatataagta catgagatta
     4741 tttccttgcc caagactttc aaaaatagct gattctttat taattgcctt cttatggctt
     4801 ctaatccatc gcttggcatg caatctttta actcgatatt tacaactttt tttgtactaa
     4861 atcttaatac atcaaactgc cttgttatac caattgaaac agagtatcct ataaaatagt
     4921 tgtcagcttt aggtatattc gttaacatcg gcaataattt ttctgaaaac tgataaagat
     4981 tttgaagttc ctttttccta aaaaattgtt ctggattatg tactatacta tcatcacata
     5041 acctcaacat tgaattaatt aattgatcat ctttcgttgt attcattata tccataaatg
     5101 aatacaaatt tattggtctt cccatggcaa tcccctttac tatttattta attaagttcc
     5161 catgattcca aataataggt acttttaact atatagatct gttctttata tcaactttag
     5221 catacattca aatgtataat aaagcctgtc tttttttggg gcaaaacagt ctctaaagat
     5281 ataacacatt ttgacttttc atctctaaca gatactcata aaaccaaaat atctactagt
     5341 atagttccta taagtatgat taaaaagttc ttaataatac agtacaggca tattaaaaat
     5401 atacacaaat gaaatatgcc caacttgaat ggcctaccgc ttacctagta gcaatcagaa
     5461 tatcaaaaag accaacaagg cataccctgt tggttctttt agttaatata ttttaacaga
     5521 aaatttattt attacatcat gaaatactgt ataaaaatcg tagcaagcac acatcacttt
     5581 tgttagccta tcattttacg tcgacagtct agctggtttc ttatctcaat tttgaaccca
     5641 ttgtttttct gctataatca tagtcgacat ttgatctgaa taatttttta tgatattgct
     5701 aaattctgtc attgattggc ttatttcatc atcatcactt tttgagcatt taaagtttag
     5761 atatctaatt ctagatctac taattgagtc tagaattttt aaatttattt ttttaaaagt
     5821 ttgtttatta tctacagata agatatattc tatcatatac aaattagcca aataaaaatt
     5881 ctgtaaataa cttttattat tcagtatctt gtcttcttta ctaagtattg ggtatattag
     5941 ttttaatttc ctattatttt tgtctattaa atactcatat ataacataca ataagaatgt
     6001 atttagcaca tataatggta attctttatt tttttttatt attttgcata cctcagtggt
     6061 atttaagaaa gttgactgat tatatttatt aagtaagcta tttgatacaa tataatacat
     6121 ttcaaaaata taatccttag taactaattt atatatattg tatccatcat tcataaaccc
     6181 gttaaaatta aaaggaactg cagtaattaa aaatattgaa aaattaaata aagaaaaata
     6241 ttgaaaaaag tcaattttta caaaaaaggt taatgtaaaa aaaagactaa atattggtcc
     6301 cccggttaac aacctcagaa ttttcttatt attaaacgta gttggtttat atctaaataa
     6361 tccaccaaaa aatccccact gtgtatttaa tctgatctta aactgatttt cccacgaaaa
     6421 ttttataaac ccaaatatta atgactctgg tctaacttta ttaaataatc caaaagctaa
     6481 gtgccctaac tcatgtacaa agatagacaa taacaaggca aagtatgctg tagacactaa
     6541 atttaattca aaaacaaaag taaagattac gagaagtaac gtaaagatca tcggagatat
     6601 aaatttcatc tattttattc tcacctcttt gtatttaagc atgctatttt tatctataaa
     6661 agaatcagca ttttcaaata aagtatttaa tacttcattt gaatctttag aattatctac
     6721 attctttgac ataatagctg ctaaagctgc gcttacttct ggagttgcta aacttgttcc
     6781 aaaagaaagt gtataaccat ctggaaagtc agcagcttta cctagtggag aaactagcga
     6841 tgtagggtaa taagtcatca tcatttcacg agcatcaatt tgtcctgtta ttttgtaatt
     6901 gtcaccatat cctcccgcag gaccatatat agaaacatta gacccataat tagaatagtc
     6961 agcaatatca ccactctttt ttgtagctcc gacggtaatt acagactcta gtcctcctgg
     7021 tatatgtttt tcattaccag tgcttatatc acgcgactca tttcctgctg atgcaacaat
     7081 tagaatgtta ttttttcttg catagttaac aacttttctg aatgcttcta cagtaaatct
     7141 ttcgtcatct atttccatat ttttatatga gccaagactc acatttatta tatctacttg
     7201 atcatttgta gcatcaacta tagctttaag catatttata gagtttccat ctgtcccatc
     7261 catcaccttg taagaattta aatttactct tggagcaatc gtgtctatta ctccagcaac
     7321 ttgtgtacca tgaccatatt catctaactc aatatcatta acatagtttt ttaatcttag
     7381 gttattgtct tgaagattag gatgaagcct atctatcccc gagtcaatta gagctatggt
     7441 tatatctttc cctagttgtt ctttcactgg atcaatatga gataaaattt ttttatatgg
     7501 ccaattaaaa gacttaaaat ctttgtttaa aatattaata tttaaaatag aactattaac
     7561 ttcttcaggt ttaaaatctg gtaatttttt cccttccgaa acattaaaat atttacctat
     7621 aaacttccta tcactatcat ccaagttttt aaaactaact aatcctattt cctgtatata
     7681 atctactttt tcagaagata attcagactc aatttcttct atagcagttg tttgcgaatt
     7741 atcaataaaa aatgaaatat tatttgaaag atctgatgca taacctgttg ttcctaatgt
     7801 taaaaaaata tatgagatta aaatataagt aaatcctctt tttttcattt tgtacctcca
     7861 aattgttgtt ttttgtaata cagtgaacga tataactcac tattttcaat aagatcctca
     7921 tgctttccaa tacatactat ttcaccatta tccattaata taattttatc aaagtttttc
     7981 acggtactaa ttctgtgagc aacagtaata actgttcttt tctcatctaa taaattagaa
     8041 aaaacttcaa attctgaaat attatccatt gcagatgtag gctcatctaa aagtaatgta
     8101 ttcacattag aatagaacgc tctagctaaa gcaatctttt gcctttgacc accagagaaa
     8161 ttactaccat tttctgatac tatagttttc tcatactgag gaattcctaa aagtacctca
     8221 tccatttttg atttactcat actttctttt agtctttttt tctcatttat agaagaattc
     8281 ggtttaaact ctaaagaaat atttttttcg atagtttcat taaaaatatg cgcattttga
     8341 ttaacataaa aaatgtttct tctattattg gagttgtttg ataaaggata gccttcatac
     8401 aatatttctc cattagaagg ttgtaacaat ccagccaata gttttagtaa agtagatttc
     8461 cctgacccac ttctaccaac aatagcaact ttatcccctt ttcttatgtc aaaagaaata
     8521 ccatttaaaa tatttttttc aaaaacagat atagtatagt aaacattatt aaccctataa
     8581 ataaactctt cttttccaac atttcctttt ttattattaa aatcattttt ttcttcataa
     8641 gttaaaactt cagataattt ttgaaaatat acatttaata gtagaaagtc attataagag
     8701 gaaaccaaac ttagaattgg cttcataacc attgttacta tagaaacaaa accaattagt
     8761 gatcctaatg acaaagaatt gttgattatt aatttaatac ctattattaa aaatagagct
     8821 ggcattacac tttgtatgat ttctggtaat attccaaaaa tagctatata tctattttta
     8881 ttttttgtaa ttaatagttg agacgtaaac atgtttttcc aatttaacaa aaaactcttt
     8941 tctgcattag cagatttaat ggtttcaatt ccttcaattg cttctgtaat aattctctgg
     9001 acgtttcctt gttccattat ttctttatct acaaatcttt ttattgtatg cgaatttata
     9061 atacttaaaa aagctattaa agagattaga acaagagcta ttattgtcag taaaatagaa
     9121 tagttaacca ttaaaaacaa atatatccct aaaaaaagac tatctattaa agttgttatt
     9181 accttttgag acaatatttg cctaatataa atatttaagt tcgctctaaa cactaattct
     9241 ccagttgatc tattactaaa atacattagt ggcatactaa aaagtttatc aatataagaa
     9301 aacattaatt taaaatcaaa ttcatactga aattctgcta ctacagagct ttttaagtat
     9361 tgaactacat ataaaacaga aaaaaaacta gttaatatta ataacagaac ataggtagga
     9421 atttcttgaa aagatctaat attatctatc gaatactttg ttgcaatagg aattaagagt
     9481 aataaaagtt gtgaaacaaa tgataatatt attaaactaa agaaatatct tttgaatttt
     9541 gtaaaaataa atgactttaa aaaaaactgt ttccttttgc cttctttttt agtctttttc
     9601 ttatgtgcgt atattaatat atttgaaaaa ttttttttga attctgaaat atcaatccag
     9661 cgtttattac ttgcaggatc taagattaat actttcttct tttttatttt ctctatgacc
     9721 acaaaatgtt gattattcca ataacttatt acaggagtcg gaagatctaa ataatttgaa
     9781 aaacttgatt taaatgtcga tacatcaaat ccatattcgt caaagacagt acgaatattc
     9841 ttgatagtta gtcctccttt gggcacccca tatttttccc ttagttctac tagtgtactt
     9901 tgattaccat aataattaag tagcatagtg atacatgcca aagcacattc actatgctct
     9961 ccttgcgcaa cgtacttcaa tcttttcata attacacctc ttataactca aaaagtaatg
    10021 cattcggaat ttcagaatct aggtttctca ataattcata acccacacca ctgattccta
    10081 caaagaatcc tagtgattct aaatactcac ttccggcaac ctttagtgta ttattttttt
    10141 caaaatcatt taacatatag ctaataagtt tatttttttt atactgataa gttccaggat
    10201 cttttttagc taattgaatt agaccttcta aagtacctgc atttccatgg cacagacaat
    10261 ctttattttt atattctatg gttttattaa tatctatatt tgaaatgtta tcatcatata
    10321 attcaattgt cgctaaaagt tcacctacag ttcccttaca ccaactattg tttttaggtt
    10381 cttcttcaaa gtatgattct ttaattttat gaagtaaaga atttgcctta tctatcctat
    10441 tgaattttga tagaagatgg acatagctat atataccgtg tccgaatcct ctgaaattaa
    10501 aatagggttc ttcggataat ttttcaaaaa tttctaatga aaattttcta tatttttcat
    10561 cctctgttat ctcggataac aataataaaa cttttattat actattatgc ccgtggatcc
    10621 aatcattttt taactcgcca ttatttatcg gtttcttttc aatcaacatg tctgcaattt
    10681 ctacggctac atttaaagag tttatatcat tatttaagcg gtaatctaca agtaaaggat
    10741 atattaaact tccttttcca aaaaaagctg acaatatatc ttcagatggt attgtataaa
    10801 ttgaattttt tatacattca attacatagt catatttatg attctttgta atgtatttaa
    10861 gagccacata aaatatgaat ataccaggca atccatcgta catattatta tttaggattc
    10921 ccacattcca atcttgatcc aactttatgt caatccaatt tacagtattg gtttttttat
    10981 taaaaatagc tctcttgaaa atttttttct ctatcttctg acatgcttga ataattttac
    11041 tgtttagctc taagccagta taaatatatt tatttgaatt ttgatttttc aaatcattaa
    11101 tatatttata tggattataa atattcaaag caatttctag ccaaacggtt tgaatagaaa
    11161 tatcttcatc acaaagatca tttattttat ttaggcatct attcagagcg ctttcttgat
    11221 aaaaatcttc tactaagcac ccgtcactag ctattaatga tgtttttgag atattgttat
    11281 aaaaaatggg tatgtctcca tctattaagt ctgaaaattc gtaatgaact acctttttat
    11341 tcttatatgg ataggcccac atattatgaa gtactttttc tctctctatt gcattagaaa
    11401 agcaattagg atggtatgaa aattccaaca tatcagcata tctttgagtt ggtctgatta
    11461 catttctaac tataagattt tgtaaattat tattaatata tgccaatatt tttttcttag
    11521 aatcctttgc tttcattaaa atacttttca taccagtaac tatatatttt tcatagctga
    11581 taaaactaat tttttcatta ttcataattg gagtattttt tgcagtatcc ataatgtgtg
    11641 tttgatattc aaaacgcatt tcatcagtaa atgtattttt aatttttaat atcttgaacg
    11701 gtacgctttg ctctttaaag tttaacgcac taaggttaac cccttcatct ttcgaatctg
    11761 acttatcttt catcgctaaa tatggtacta gccctgtcac cattatagaa tctaaatatt
    11821 tatatttagc atctactgtt gcgctattac caaactctat aggaatattt tgttgaaaaa
    11881 aagtttcgtt atctatgata acagggtatt ctccatgagc gattatattc tcatagtgta
    11941 agtctgttac attaaataag aaagctattc cgattagttt accatacctt tcataatatt
    12001 tttttacttc ttctatgtta tttatttcta tattatctat atattcttca tagaaatagg
    12061 tatttctagt aactttttta actatataaa tatctgcctc taattcttta tttaaaaatt
    12121 caaaaaaatc tcttaattta ttctcgctat taatctttgg cttgtatact atcttctttc
    12181 catcagaaaa agttagtgta gaaacagttt ttccgcgact atgagagtct ccctgtgatt
    12241 ctgatataga gttaagctct gaggattgta tgttaaaaca attttgtatg ctaggtaaat
    12301 cttcagtcac tcttataagc atttgtttag tattatctaa aaaatatctc attctaacaa
    12361 cagtaatacg catcaactca ggatagcatg tataaaaagc tattatatct tttttagagt
    12421 taaatctttt ttttagataa tagataaatc gcttgctact atcatttccc tttagaggtt
    12481 catttttttt aaaagtatgc aaatctagca ctaatgtttt acttgtcaag tgaataagct
    12541 cttgtgttag attttctaat aaattaataa tgaattcttt tgtacaaata tttaactctg
    12601 agtttaaatc aagtaaaaat aaacgagcat attgtaagaa atatctaaaa ggataactag
    12661 catctacttc taataattgc tcttcactat cattataaga atctaaaatg gattcaaaaa
    12721 aaatatacca tgattgatct ttaatgtatt gaattgcaac ttctttatca ggaaagtttt
    12781 caataggtgt tattcctaat ccaaaattat ccagtgattc atatttatat ttaatcaagt
    12841 agtctaaatc atcttgttta agaacacttt ttctttcttt ccaagcttgt aaatttttaa
    12901 tgtcgtactt ctcgttacca ctttgcttta gtaaaaagca tctttcattt atgcttaaaa
    12961 catttattaa attatcttcc atgtaagcac tcctttttta tgtataagag ggctagtttc
    13021 actagccctc ttaatatata aattagcaaa atttagctga aaataatgca cctactccta
    13081 agcctatggt aaaacatgct ggagttgtct cagcctgaac atctccacta ccttgaatcg
    13141 cttccatttc ttctaaactt aactcttcaa aagaaggacc aacaagttct aatttattag
    13201 agtaatagtt ttcttgattt tccttattta gcactgtgct tcacctcact aagttttata
    13261 gtatatttta acaatgtttt aaagacacaa ctacagttac tccagtaaaa ataccgccac
    13321 caacccagcc acaagcagca ctacttgctg cagctgtcgc cgcaacagca cacaccggtg
    13381 ttgtctcagc ctgaacatct ccactacctt gaatcgcttc catttcctca acacttagtt
    13441 cttcaaaact aggaactaca cttaaatttt ccataattct taccctccat cataaaattg
    13501 ttgtatattg cataacataa tatgttacaa tttaatatta tagagctttt aatcttttgt
    13561 caagtgtcac ttgacaaaaa ggaggaacca aaatggctat ttttattttt ttattggata
    13621 tcatttctgt agtctacttt gtttttaatc tgactgattc aaaaaaagat gagcgaattt
    13681 tatatacaat ttccttaaca tctacttaca tgtacttatt tattaacttt tccatactta
    13741 tagtagttgc tatttttctt tttctaccta atgttattac taaaaactat ctctttaatt
    13801 ttatctacta ttacttctct ctatcaatga tattgcactc tctgttacta ctttttttca
    13861 acaagaggac ttcataaatg ataatcaata acttaaaatt aattagagag aaaaaaaaaa
    13921 ttagccaaag tgaattagct gctttattag aagttagcag acaaactatt aatggtatag
    13981 aaaaaaataa atataaccct tctttacagt tagcattaaa aattgcttac tacctgaata
    14041 ctccactaga agatattttt caatggcaac ctgaataaaa aagattttta aatttcacca
    14101 cagaatattt aaattaaaag aaaggtgctt cgtatgaaga aaaagtttat atcccttctg
    14161 attttatttt taggaataat tgttggcata gtaacagttt atattttaaa gcataaataa
    14221 ttatgactgt tgttttatac tttaatcata actgattttt tatcagtaaa accctcactt
    14281 atgattacat tcatttaaat aaaaactagg ctcaaatgta tagtaaagac tatctctttt
    14341 tggggggaga cagtctctaa ggttataact tattttagcc tttcatttct aacgcatact
    14401 catagaacta aatgattgat taattcagtc tgtaagaaaa tagttaaatc tgaagtgact
    14461 tgtaattatt ctacagtata cccactgtcc tttcaacaac tgtcgaaagt ttagcaaaac
    14521 attttacaat atttttgtat acatcattat taataataga gccaatacca gaaaatatcc
    14581 gaatagcact ttaaaggttc tactttggtt attttcaggt agctgactta ttaaatagac
    14641 acctgacatc attataagaa cataagtgaa atagtaagtc cttgatccag atacccatat
    14701 ggtaggagag aaccccatca taatacgact tcctacaccc aaaataagaa gaaagataac
    14761 tgataaaaat tctaagggat tattacttgc cccaaaaatc cctattacat aaagaaaaac
    14821 caacccagta agaagaacta ctagtgacat atatgttttt cctgaaacta tatcataagt
    14881 ttgatcaata atcgtattaa atcttgtaca aatcaaatac gtcaatagcg gtattccact
    14941 aatcatcttt ttgactaatg tcccattttt tactagtcca gcagtaagaa ttagcaatac
    15001 aaaagctaac atcaatggag accactcaaa aaataaagct ttcaaagtgg acgaataccc
    15061 tatttgtaac ttatcaaaaa tactgtagct agaaaaatta ggtaaccatt gtttcgtttc
    15121 ttggacgttt cttgccgcat tccccttaca tgttaaaata aacacaaggc tagcgattac
    15181 aatagcaata tgaggtaaag ttatcaagat attcatttta gataaataca gaatacctgc
    15241 caaaactaat aaagaaacta acataataac taccatttgt tcttggtttg tagcataaat
    15301 caagaaaacc aacgataaaa taaaggatag ccaatttaca ctttttcctc ttatatagtt
    15361 cataataggc caaatactta acaacgctgc tgccatgacc caaacataat ttgttgttgt
    15421 tgctatccat cctgcattat ttatcatcga agcaggaatt aataatgaca tgccagtacc
    15481 tataattaat cctcttcgcc tattatctga gttaatcagt agtgcaggga caattgccac
    15541 tatagacatt gctatagcat ttaaaactct ccacaaaaat acgtgttgta ccgcttgtgt
    15601 tagagctatt tcaatcacta atcgagacgt ccattcattg tacctaaact ccaaaaattc
    15661 ataatagtta ctttgaaaat catgtgtaaa ctgctttaag aaaaacgcat cgtccccaaa
    15721 ttccatttgt ttaataccaa aattgtaaat taacattacc acaaatacaa aactactgag
    15781 aattaaaata tctctctttt ccactttatt tatcactatg tcactcctat cctccatttt
    15841 tttcaaggac atgcgcttta taaatactat cgatactaga cattggaagc ttttctaatt
    15901 cttcatacgt aaagtcacta ttacgtacaa tcaatattat tttttcttct ttagtcattg
    15961 ctactccctc actttcattg ttctatcgat ttggcttgta ccctcttcat aattgaacac
    16021 gacgtttggc tgcacattat attcataaac attgaaattc agtgtacccg cactgtcaat
    16081 cgcttgtaac caataacctc gaggcattaa ttcctttcca cgaaaaactg tcacgatctg
    16141 ataaatgact ttgttcccct taagcttttg tgcatctctg actagtttct catagtgcgt
    16201 ctgcactttt tgattagaaa aagctgtttg tgttgccagg tttttgggat tgtcttggct
    16261 tccattttca cctatcttaa agtttccgtc aatatcaaag ttaaagctgg acgtataggc
    16321 aagtaaatgt ccgcgattca caatcggatc tccatcgatc tgtttttggt gccaaccagt
    16381 cggttgccag acttgccgtt ctcgtccttc agaacgtcct aaattcttcc tatcaaggta
    16441 ggcagtcaca aatgttgtcc ggttcaaaga atctaagtct ccataaatca ctttgttttc
    16501 tttccacgtg gcaatatcta aactagattg tccgttattg acctctatag cggcttttcc
    16561 gccactttga aagtctaggt tagctaattg attatattgt tgttgatcgt atggcgcact
    16621 tgtggatttc tttgttttta catttcttgg tttctttgta agtgactttt tatctgattt
    16681 cgccacttct tgaaagatat cattagataa aaaagacgag agctgctctg ataagtctaa
    16741 atgattcaac aatccaaaac caattatcac caaggacaat agactaccta accaataggg
    16801 ctgttttttt cttttaactt tcatcgtatt tgtcctcatc atcttgactg aataatgtat
    16861 ctatatcaaa gttttcatag aacttgattg tttcttgaaa ttcttcctca gttaatcgat
    16921 ctgttggttt atgatgaaat tttgcacttg agtgaatccc gtaaaccttt gctagtgttt
    16981 gaaaaagttc gccataagta cgtgttttag ggatacgatc gtatgttact ttttgcgcaa
    17041 tatcggtaac gactaaatca tgaccgaatc caccaaatac ttcttggtat tcaaaatggt
    17101 atgctggata taaactgttc aattcattaa tagcagattt cacatcttct gctagatagt
    17161 tatccaaaca aaagcgttgt ttaatggcgt ctgattgcgc cattttttct attatggaaa
    17221 attctgttaa aagttgttgt gccgttactt ctctcatttg tttttgtcct ttcgattatt
    17281 tttatcagtg agtggggcaa taactgttcc ttctaacgca cgttcccgtt ttgtttgctt
    17341 ttctcggcgt tgtttcaaac tttcttgata ctttttgctt aattctttat tagacatttt
    17401 tcgcttctcc tttacaattc ctaagagtag aaattttcta ctcttaggaa cccttttgat
    17461 ttagttgttt ttactctgca tataaaactt ttcgtccgta gctaatttgc ttaatttttt
    17521 gtaaatcaat agcttcacgc gtcaatgtat cataggcgtc acgttccttt ttgttggtaa
    17581 tatcgtaact cgagaagtaa tcacgactgc tatctatgat gtttctcatc ttgaatgtca
    17641 gttccttatc ggaaatttgg tacgtcaccg taatggtttt cattccttta ttctgcactg
    17701 cttgaataat ttccttttct ttttggaatt gtttattctc tgctaattct tttgcatact
    17761 gttgttggaa ctgtagtttt tgtaagtgtt cagacaacat ccttgcgttt ttctctaaat
    17821 atttttttac taatcgtgat tgtgtagctt gtttctccgt tagtaagtct aatatctcac
    17881 tgtctgcgca ttcgtactga acaaacgaat gatccataat gaacgtagtt tgcccatcga
    17941 gtagtttttt tcgcacttca ttttttagtg ttgttatttt ccagtctgat aagtccgcta
    18001 gatactttcc ttccagtgtg taatagtagt tgtagtgttg attgatttca gcaagcgttt
    18061 gttctgccag ttctctttcc agctgttgaa tcacttcgtg aagatcttta aaacctgtta
    18121 tatctacacc ctttaaatgc cattcaatca aatactctgc ttgtgaaaag aatgtatctg
    18181 tcacgctgtc atatatgccg ataacgtctc ctattgactc attttgccga aaggaaaggg
    18241 actctccgtc ctgtaaaaag ggattcaaaa gacggagaaa aagcgggtac ttttcgggtc
    18301 gatcattatc ttaaccagcg actttgtctg tttttcctct tgaaaaataa aggtttgttg
    18361 gctgctacat aaaaagtcat gaaatacttc ggttgttagt gtcataattc ttacctgctt
    18421 tctctttttg attttttttt gtacttgtca aagaaacgta ggtaagttat acttaaaatc
    18481 tataatttgt taaatataac taccttttta gaaatctttt gtcgtaagca aaaggtttct
    18541 tttttttact tttcaagggc gttcttccga tattcttccc atgcttttcc ataaatggta
    18601 tagagttcgt gccaatctct gttcattaat gccaacattt gctctaattc ttcgttatcc
    18661 tccgagcgga tactctcgtt ctctagtttt tccatggcgt aaacaagtga atctaatgtc
    18721 tgaaaggctt gttctttgtt catttggttt ccttctttcg gttttgattt ttgaacaacc
    18781 atttttgtta ggcgcttgag gaagtgaagc tggacggtca aaaatttctt ttcgtcaaac
    18841 ggtgtagtct cccccctttt tcgttttcga ttaggttgtt cattttcgcc agtgtgttcg
    18901 tgtcgttcgc tgtgccgaga aaggaccgta gacataaaga aaaaacaagg gcgagcttgc
    18961 tcgtttatat acccttgttt tttcgactgg ctatggtact gtaacaaaca gtgaacagca
    19021 cgttacacac ggcaaaagga acggcctgaa aacgaaaaag gctgcgtgac accgttctga
    19081 catcagaaaa gaaatttttg accggaatgt tcttgacctt tgccttgtga aacaaggctt
    19141 tcttccgaac ggcgtggcgg ttggagtaag gaagaaacag ctcttttctc ttgattcttc
    19201 tttatgtaaa agccttgtat tgcaagcaat acaaggcttt ttatgctata atagaattga
    19261 tagtaaagtt taatgacggt ggctatccaa tcgaaagtga ggtggtgcgt atgaacgtac
    19321 ttccaaaatc tatagaaagg agaagccttt tgtccgtttc ggaaagtttg caactaatgc
    19381 ttgcgtttgg tgggtttaca ttgaccctaa tcacaaccat tgttgccatt ctgaactata
    19441 aagacaaaaa gaaataaccg tcactttagc aggagaccgg ttatttctaa ataacttata
    19501 aaaactctgc cacgtcttta gcggtgctat caatgagggc gtattaccag tacgtcctct
    19561 ttacataatt attataccac attttgtgcg aaaaggtagg cgaatgccta ccttttttca
    19621 tgcgcgccta aacggggtgg cggttggatg tggcgcgcat gaaaaaacag atctattgat
    19681 ttagccatat tcagacaacc cgttcatgga cggttgttgg tagacatttt gttgtgtagg
    19741 tgcttgattc attgctggtt gttcattaac cgttggggtt gattgtcctt gtgggactgc
    19801 gtgttgtttt cttctcgttt ttgtacggtt tctttggact ctaaaaactc aaaatcttct
    19861 acaactaatt ctgtcacata atgcgtaacg ccttgttggt catcatacga acgagtttgt
    19921 agttccccat ttacaccaac taatgcgcct ttttgcgtgt attttgcaaa gacttgggcg
    19981 gtttgcccca taaaacacat tgaataaatg tggtcggcac atttccgtta gtgtctggtc
    20041 tttttcgctt acaagccaat gtaacgtttg cgacactctt tccgttagtg gtggtacgta
    20101 gttcggctcc ttttgttaaa cgcccgacag ctgataattg aatcatgatt gtttccttct
    20161 ttctgatttt ttatttatat catgcccttt ttagtggcaa taatatcttg ttaagtgaag
    20221 ttttttgaaa tgagagtgat ttgcctgtct aggcaaatca cctccttcta tctgccatgc
    20281 ccttatgagg gcatggcttt ttcaatctct atttgccatt gttcaatggc ttcttctact
    20341 tcttctggta tgtgtccccg attgtatttc ccttgcactt gtatcactct ttttcacggt
    20401 attctaaggt aaaatatggt ttatctggtt cttcttttct tcggataaaa acaatcgttg
    20461 tttttccttt tgtatgttgt tcaaggtaat gttggctacc aacacaatgg tgcaatacct
    20521 gaccttcctc cacaatttct tgcaacgaat gtggggcgag aaaagtaagt cgtcaatttc
    20581 gtttctaatg ctttcagttg ttttttcgtt cttggtattg ctgttcttca agctctcttt
    20641 caagtaaatt caacgtattt gtggcattgt catgggctag ttgcaagttt tcagggaaaa
    20701 gcacatcatc agtaaatggt gtattcagtt ctccagcatg tgtaaatagt ccatatagta
    20761 gctaaaacgc tcgccttttc gcataaacca gtgttgaaac ttggttaagt tcacttcttt
    20821 aggtaattgc ttaattttga ataatgtaaa taattttcaa ttccttctat tctcgcaact
    20881 tttcgctcct tcaaagtttt ttctagcata agcatatgaa acgttggttg gtggttttta
    20941 gtcgcttttt attggctttt agccagttct tagtaataac tctcatgtct acttttttat
    21001 gcatgtgcaa aatattgcgt tcatcatcaa aagtatttcg tttgccagtg tcgttgcacc
    21061 tattttttgt aaaattcaat ttcattgcgt atttataaca tgcgccagtt cttggcgact
    21121 aattgtaggt agcttgaggt atttcattcc gaaatggtcg ttagtttttc ttgccagtta
    21181 tttgatagaa aacagtgttc gtgtaagcac tactcatgta accataattt gctaacaagc
    21241 cctcatgcca gtgtccgttt tcataatgtg ctttaacatg ggtatcattt gaaaaccgtt
    21301 caaggtttga cggctcatag ataagggttt ctgttccatc tgtaatcgtc tgccaataac
    21361 tatgggtttg aatttcaatt cgttttgcac gaacgagaat gattccaaag gagtaaaatt
    21421 tcgttggaaa cgataatcgt gagtatttcg ttaatcgttt tttatggtgg ggcaattctt
    21481 gcgagaactc gcaaaattgt ctcctttttg ttttgccatt catacgttgg tatttgtgca
    21541 gtacaccagt taaaaaaggc tttgggtggg ttaatggttt tggtgttttt ttattcatac
    21601 gcactcgaac aaatcaattt gttcgtccac ctcttttctt tcaggtttgt ttctgatttt
    21661 ttggtcggtt tctttttgtt tgtggtcgtt actttaccaa ctgctttggt ttctggtaat
    21721 ttctctaata agaaatactc ttttatccaa ctgaaaacca cttcgtccgc caccatggcg
    21781 cttgattggt ctttggattg ttcttgggct tttcctatgc agtaagtcat agcacctttt
    21841 aacgttctat cttctttgag aatacctaga aaaagcgctt cgtctgtttt cggcataacc
    21901 agttatgaac aacttctagt gtactgtcat ggtcggtttc tagttctttt aacattttct
    21961 caaaagcttg ttcttgcgtg ctttcttgag ctgtaaagaa aaatcgttcg taagaatttt
    22021 tgtcgctaat cactagccat tggtagttgt ttccttggtc tatcgtttcg tcaattgtta
    22081 gaaaaagtga cgagtagtta ccgtcatggt ctttaatcgt aacgattgct tgttcaggta
    22141 acttttcaag gtaagccagt aacgtttcta ctggataaag agctacctca taatttggat
    22201 aaaaacataa aaactgaacg ttttttccgt ctttttctat cacttctttt ttaaaggcga
    22261 cactgatata gccttgtgta tcatcaaaaa tcgtagttgc gagtgtttgt ttgtattgtt
    22321 tcagtgcgta tcttaattct tttacagttt gtatattttg aaagtccata acgtttcctc
    22381 atttcttgta agcttccctc ttaaaattta agaggggagc aaattttcac ttgtcaaggt
    22441 cgttaggtaa gttatacttg agttacaatt aattcaagtg taagtacctt tttagaaatc
    22501 ttttgtcgtt agcaaaaggt ttctttttta tagtaaattt ttaagttttc cattgttaat
    22561 ttcccactcg taccattctg taaaatcttg agggaaacca ttgaccgcat attttgcttg
    22621 ttctttggct tcttcttcgt tgattgggtc aagggctgtc ggtttgtctt ttggtcgtgc
    22681 ataacagcct atccatgttt caaagtcgcc ctcaaagcaa ccgtcaataa tcaatcccca
    22741 ttcgtttaat tctgttcttg cttgttcttt tagttcttca attctgtttc tcatatactt
    22801 tcagtccttc cattctttat gatttagaaa atattctagt tgatataaac ggtcattcgc
    22861 atttttcaaa caaccataat taagtagtaa cgtcactgtg tcatttgtga taatggcttc
    22921 acttaatttc tggtgttctt ttctggcatg ttccagtttg aatgttaaat gtggggtatt
    22981 ca
//
