LOCUS       NZ_KZ679082            22736 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Streptomyces sp. CS149 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ679082
VERSION     NZ_KZ679082.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS149
  ORGANISM  Streptomyces sp. CS149
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7754255)
  AUTHORS   Malmierca,M.G., Perez-Victoria,I., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Cooperative Involvement of Glycosyltransferases in the Transfer of
            Amino Sugars during the Biosynthesis of the Macrolactam Sipanmycin
            by Streptomyces sp. Strain CS149
  JOURNAL   Appl Environ Microbiol 84 (18), e01462-18 (2018)
   PUBMED   30006405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7754255)
  AUTHORS   Olano,C., Malmierca,M.G., Mendez,C. and Salas,J.A.
  TITLE     Characterization of the biosynthesis gene cluster for the
            macrolactam sipanmycins: involvement of four glycosyltransferases in
            the transfer of two aminosugars
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7754255)
  AUTHORS   Olano,C., Malmierca,M.G., Mendez,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2018) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 556.87x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 11:43:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,915
            CDSs (total)                      :: 6,834
            Genes (coding)                    :: 6,691
            CDSs (with protein)               :: 6,691
            Genes (RNA)                       :: 81
            rRNAs                             :: 12, 7 (16S, 23S)
            complete rRNAs                    :: 12, 7 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 143
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 52 of 144
            Pseudo Genes (incomplete)         :: 108 of 144
            Pseudo Genes (internal stop)      :: 12 of 144
            Pseudo Genes (multiple problems)  :: 27 of 144
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:40:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4327560
            Orig. end                         :: 4350296
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ679082.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Professor JA Salas
            laboratory.
FEATURES             Location/Qualifiers
     region          1..22736
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="14"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22736
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22736
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12736](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12736
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    118..132
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 22.27"
                     /tool="antismash"
     misc_feature    complement(567..581)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.9"
                     /tool="antismash"
     gene            664..1515
                     /gene="otsB"
                     /locus_tag="C6W96_RS19955"
                     /old_locus_tag="C6W96_19925"
     CDS             664..1515
                     /EC_number="3.1.3.12"
                     /GO_function="GO:0004805 - trehalose-phosphatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="otsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958814.1"
                     /locus_tag="C6W96_RS19955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19925"
                     /product="trehalose-phosphatase"
                     /protein_id="WP_107412666.1"
                     /transl_table=11
                     /translation="MGSHPERLPNPTTPAGREGLDAVLARPDRAVVALDFDGTLADIVP
                     DPEQARAHPGTVEALAALAPKVAAIAVITGRPAGVAVRYGGFAGVPGLEHLVVLGHYGA
                     ERWDAVTGTVHAPAAHPGVTAVRAELPGVLHEFGAWSGTWIEEKGQAVAVHTRRAQDPQ
                     AAFESLRGPLGELAAKHGLIVEPGRLVLELRPPGMDKGVALAGFVAELDAESVIYAGDD
                     LGDLAAFAAVEKLRGEGPDGIPGLLVCSGSAEVPELAERADLSVPGPAAVVDFLAALAE
                     RL"
     assembly_gap    1517..1541
                     /estimated_length=25
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<1542..2917)
                     /locus_tag="C6W96_RS19960"
                     /old_locus_tag="C6W96_19930"
     CDS             complement(<1542..2917)
                     /EC_number="2.4.1.15"
                     /GO_function="GO:0003825 - alpha,alpha-trehalose-phosphate
                     synthase (UDP-forming) activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126480.1"
                     /locus_tag="C6W96_RS19960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19930"
                     /product="trehalose-6-phosphate synthase"
                     /protein_id="WP_107414995.1"
                     /transl_table=11
                     /translation="MVSEHTTSSNAQVLVASNRGPVTYTLGEDGTLDAKRGGGGLVSGL
                     SAVDDKLWVCAALGDGDREAVRRGVGEPGVRMLDIDAEVHADAYNGIANSVLWFVHHLL
                     YQTPVEPVFDTEFRRQWAAYETYNRAFAEALAQEAGEGAAVLVQDYHLALVPGMLRGLR
                     PDLRIGHFSHTPWAPVDYFRLLPDDIAEQLLRGILGADRAAFLTRRWADAFIGCCTEIL
                     GGTGRTRIGVHGLGADADFLRRRSHEADVDERMAALREQVGENRKTIVRVDRTELSKNI
                     VRGLHAYRTLLETRPEWRERVVHIAFAYPSRQDLAVYRDYTAAVQSLATEINGEYGTES
                     WTPVVLHVKDDFARSLAAYRLADVALVNPIRDGMNLVAKEVPVVSDQGCALVLSREAGA
                     YEELGEDAIVVNPYDVTGTAEALHEALTMSGDERSGRTKRLAEAATALPPQRWFLDQLE
                     A"
     gene            complement(3012..3962)
                     /locus_tag="C6W96_RS19965"
                     /old_locus_tag="C6W96_19935"
     CDS             complement(3012..3962)
                     /EC_number="2.4.1.266"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511020.1"
                     /locus_tag="C6W96_RS19965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19935"
                     /product="glucosyl-3-phosphoglycerate synthase"
                     /protein_id="WP_107414996.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.6e-09,
                     bitscore: 35.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEEVERWLTRRSWSSGDRPLNRLTDARAADPRRTSVSVVLPALN
                     EEATVGAIVAVIRRELMEKVRLVDELVVIDSGSTDSTAAVARAAGARVVHRDAILPRIP
                     ALPGKGEVLWRSLLVTSGEIVCFVDADLKDFSADFVSGTVGPLLTDPAVQFVKAMYDRP
                     LGGRAGQGGRVTELVARPLLNLHWPQLAGFVQPLGGEYAVRRSLLERLPFPVGYGVELG
                     LLVDALHTVGLDALGQVDVGVRVHRHQDGQALGRMAAAIYRTAQLRLSRGHLVRPVLTQ
                     FERGEDGFVPRTHAVDTEERPPMREIAEYAERHAA"
     misc_feature    3988..4008
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.9"
                     /tool="antismash"
     regulatory      4116..4243
                     /bound_moiety="S-adenosylmethionine"
                     /db_xref="RFAM:RF00162"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00162"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="SAM riboswitch class I; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            4262..5557
                     /gene="thrC"
                     /locus_tag="C6W96_RS19970"
                     /old_locus_tag="C6W96_19940"
     CDS             4262..5557
                     /EC_number="4.2.3.1"
                     /GO_function="GO:0004795 - threonine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056010.1"
                     /locus_tag="C6W96_RS19970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19940"
                     /product="threonine synthase"
                     /protein_id="WP_078654854.1"
                     /sec_met_domain="PALP (E-value: 1.1e-60, bitscore: 204.2,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQTVAGNATTASPDLGPAAALSCRECGERFELGPLFACASCFG
                     PLEVAYDLPTGSPEELRKRIEAGPDNIWRYAPLLPVPADVADKPNLNPGFTKLVKADNL
                     ARELGVTGGLYVKDDSGNPTHSFKDRVVAIAVEAARAFGFTTLSCSSTGNLAGAVGAAA
                     ARAGLRSCVFIPHDLEQGKVVMAAVYGGELVGIEGNYDDVNRFCSELIGDPLGEGWGFV
                     NVNLRPYYGEGSKTLAYEICEQLGWRLPDQIVIPIASGSQLTKIDKGLQELIKLGLVED
                     RPYKIFGAQAEGCSPVSAAFKGGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARRTGG
                     AVEDVTDEQVVDAIKLLARTEGIFGETAGGVTLGVTKKLIEAGVIDPTLTTVVVNTGDG
                     LKTLDAVSATSQATATIKPSLDAFRAAGLGTA"
     gene            5598..5876
                     /locus_tag="C6W96_RS19975"
                     /old_locus_tag="C6W96_19945"
     CDS             5598..5876
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265553.1"
                     /locus_tag="C6W96_RS19975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19945"
                     /product="MoaD/ThiS family protein"
                     /protein_id="WP_006126483.1"
                     /transl_table=11
                     /translation="MSVKVRIPTILRTYTGGQAEVPAEGTKLSEVIESLEKDHPGIAAR
                     VLDDQGKLRRFVNVYVNDDDVRFEGGLDAATPDGAGVSIIPAVAGGC"
     gene            6331..6537
                     /locus_tag="C6W96_RS19980"
                     /old_locus_tag="C6W96_19950"
     CDS             6331..6537
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967346.1"
                     /locus_tag="C6W96_RS19980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19950"
                     /product="cold-shock protein"
                     /protein_id="WP_003967346.1"
                     /transl_table=11
                     /translation="MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQ
                     RVEFEISQGQKGPQADMVKLAVG"
     misc_feature    complement(6379..6392)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    6741..6756
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(6744..6759)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            6911..8533
                     /gene="groL"
                     /locus_tag="C6W96_RS19985"
                     /old_locus_tag="C6W96_19955"
     CDS             6911..8533
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /gene="groL"
                     /gene_functions="other (smcogs) SMCOG1299: chaperonin
                     GroEL"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006133870.1"
                     /locus_tag="C6W96_RS19985"
                     /note="60 kDa chaperone family; promotes refolding of
                     misfolded polypeptides especially under stressful
                     conditions; forms two stacked rings of heptamers to form a
                     barrel-shaped 14mer; ends can be capped by GroES; misfolded
                     proteins enter the barrel where they are refolded when
                     GroES binds; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19955"
                     /product="chaperonin GroEL"
                     /protein_id="WP_003967345.1"
                     /transl_table=11
                     /translation="MAKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGA
                     PTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLR
                     NVAAGANPMALKRGIEKAVEAVSAALLEQAKDVETKEQIASTASISAADTEIGAKIAEA
                     MDKVGKEGVITVEESQTFGLELELTEGMRFDKGYISAYFATDMERMEASLDDPYILIVN
                     SKIGSVKDLIPLLEKVMQSGKPLLIIAEDVEGEALSTLVVNKIKGTFKSVAVKAPGFGD
                     RRKAMLADIAILTGGTVISEEVGLKLENAGLDLLGRARKVVITKDETTIVDGAGDSDQV
                     QGRVNQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVR
                     NAKAAVEEGIVAGGGVALLQASAVFEKLDLTGDEATGANAVKLALEAPLKQIAVNGGLE
                     GGVVVEKVRNLPIGHGLNAATGEYVDMIAEGILDPAKVTRSALQNAASIAALFLTTEAV
                     IADKPEKAGAAAPGGMPGGDMDF"
     gene            8751..9260
                     /locus_tag="C6W96_RS19990"
                     /old_locus_tag="C6W96_19960"
     CDS             8751..9260
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610344.1"
                     /locus_tag="C6W96_RS19990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19960"
                     /product="hypothetical protein"
                     /protein_id="WP_234389347.1"
                     /transl_table=11
                     /translation="MSVSATGRTGGRGRLKGVSLVVGGAVLLVVGLFAVVTGTGLSGVV
                     GMRVETFGRIECHDVRTEKGQTVWHCSGESAAQQRANAAERDRAAREALRAHVDGMPRS
                     AEISRSRILFADHDGRTDPETITATQVFDGGRWYAHSSMLVGYGMIPLLLGAGTAAWGG
                     YLLRKR"
     misc_feature    9517..9532
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.92"
                     /tool="antismash"
     gene            9819..9950
                     /locus_tag="C6W96_RS19995"
                     /old_locus_tag="C6W96_19965"
     CDS             9819..9950
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019762774.1"
                     /locus_tag="C6W96_RS19995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19965"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_010071616.1"
                     /transl_table=11
                     /translation="MKQQKQQKKAYVKPSMFQQGDFSKKTAGYFVGSYKEYWSRRII"
     CDS_motif       9819..9899
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MKQQKQQKKAYVKPSMFQQGDFSKKTA"
                     /locus_tag="C6W96_RS19995_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       9900..9950
                     /prepeptide="core"
                     /locus_tag="C6W96_RS19995_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-1.40"
                     /molecular_weight="2006.3"
                     /monoisotopic_mass="2005.0"
                     /core_sequence="GYFVGSYKEYWSRRII"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MKQQKQQKKAYVKPSMFQQGDFSKKTA"
                     /leader_location="[9818:9899](+)"
     gene            10001..11982
                     /locus_tag="C6W96_RS20000"
                     /old_locus_tag="C6W96_19970"
                     /pseudo=""
     CDS             10001..11982
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056005.1"
                     /locus_tag="C6W96_RS20000"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19970"
                     /product="asparagine synthase-related protein"
                     /pseudo=""
                     /sec_met_domain="Asn_synthase (E-value: 3.1e-29, bitscore:
                     101.4, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGQLRDYFVVLPDSAAGAAAAGRLPVPGAAAGRSAAPDATGSAR
                     EVGGALTVAHPSGRPWIVARPLVRKVSHLARGEDALVLIGPDRVPDAVLAGILEGARDR
                     TGLEHRLARVPGLYHVVARLSGRSWIRGTATGLRRIYHARHPAAGTIASDRPAVLAHLI
                     DAPLDESALALRLLDFLPHPLSRRPVWRGVHETGAGYGLALPVAAPGTAAVPGPTEHRW
                     WEPPPGELPLAEGAREVGDAVAASVRAHVGGLDRISCELSGGLDSTALAFAARDTGPAS
                     LSLLTVAARDRYSEDETWARRAVEAAGGTAAPGGGCGAAPALDHHLIPAADAPYFYADL
                     ASTAAELNDEPLPVAPGRARAALLLGRARATGSRYHLTGYGGDEIFLGLPHAYQDLFHG
                     NPFTAWSHLGGLRHQLGWPLLPTVKALLDRSAFPRWLAGAVTAAPQPVARTPLLSWGVR
                     QSLHPWLTEHATTLIAEEFRAAAEHAEPIDPWRGRHVDIDGVRMGARHFQAMEDIGMTI
                     GLPVAAPFYDDRILEATLAVRLPERISPWRYKPLLVEAMRGVVPDALPARTTKDHMASD
                     EHQGLREHAPELAELWTGSRLAEHGLVDSRQLLRLAAEPFSPVLVEHSISSTVAGETWL
                     RTAENAWPAPQLTL"
     aSDomain        11979..12224
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C6W96_RS20005_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="6.90E-28"
                     /identifier="RREFam002.1"
                     /label="C6W96_RS20005"
                     /locus_tag="C6W96_RS20005"
                     /protein_end="82"
                     /protein_start="0"
                     /score="87.5"
                     /tool="antismash"
                     /translation="MKLRKGIAVTTTEYGGVLLDEKSGSYWQLNDTSVIVVETLAAGRA
                     PEAAVERIVAEFDVERAEAESDVAELTRRLVEAKILR"
     gene            11979..12230
                     /locus_tag="C6W96_RS20005"
                     /old_locus_tag="C6W96_19975"
     CDS             11979..12230
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126488.1"
                     /locus_tag="C6W96_RS20005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19975"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_006126488.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.7e-25,
                     bitscore: 87.5, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.3e-13, bitscore: 47.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLRKGIAVTTTEYGGVLLDEKSGSYWQLNDTSVIVVETLAAGRA
                     PEAAVERIVAEFDVERAEAESDVAELTRRLVEAKILRP"
     gene            12227..12736
                     /locus_tag="C6W96_RS20010"
                     /old_locus_tag="C6W96_19980"
     CDS             12227..12736
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071618.1"
                     /locus_tag="C6W96_RS20010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19980"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_107412669.1"
                     /sec_met_domain="PF13471 (E-value: 1.8e-22, bitscore: 78.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEMTMPRRGAGAGGTRLRAAIAAAFVLARFKPGRLRRVLARCA
                     RGARPASYAETLEVLEAVTATSRRCASRYGCLPRSVAVALACRMSGVWPDWCAGVWATP
                     PFSPHAWVLAEGRTVGEQAEAADLRPLMVVTVREGVQGERGGGDDGGGGTGGSGPGPGP
                     GTGQTA"
     gene            12651..14552
                     /locus_tag="C6W96_RS20015"
                     /old_locus_tag="C6W96_19985"
     CDS             12651..14552
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379740.1"
                     /locus_tag="C6W96_RS20015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19985"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_107412670.1"
                     /transl_table=11
                     /translation="MSAVAGTTAGAGQADPGPGPVPEPGRPPESTERPGPESPDRTPLA
                     PAAPSTPPPASSPSPLRLLLARVRPHRGVLIRAGLLSLAGSGAGLAMPLMAKHAVDTFA
                     DGRSPVAPLVALTALVLAGACLSAYGSFLMSRTGEGVVLRARDQLVGRIMRLKVPAVDR
                     LTPGDLQSRVTSDTTLLRTVLSSGLVESFNSVLMLLGTIALMAYMDLTLLGVTLVVVVG
                     IGAVTSLLMPRIQRAQLKAQESVGAMGAALDRVLQAFRTVKASGAEERETAAVAAAARH
                     AHDRGVSVAKWASVTEVTMTMSIQLAFLAVLGVGGARVASGSLEISSLIAFLLYLFYLM
                     GPIGGLVEGWTGLQSGLAAVRRIDEVESLPGEPADRSGGLKKKGDGGPLGVTFQDVTFG
                     YGDERAPAHQGVTFDVPAGGMVALVGPSGAGKSTVFSLLERFYDHEAGTITVGGRDIRD
                     WPLAELRGSLAYVEQDAPVLAGTLRENLLFAAPDAEEKELTAAVARTRLDALVERLPEG
                     LDTAVGHRGVTLSGGERQRIAIARALLRHPRLLLLDEVTSQLDAVNEQALRDVILELAE
                     QTTVLVIAHRLSTVRHADRIVVLEEGRVRTAGTHEELIAGDELYRELATTQLAADAR"
     gene            14748..14873
                     /locus_tag="C6W96_RS35600"
     CDS             14748..14873
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C6W96_RS35600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_267899024.1"
                     /transl_table=11
                     /translation="MRYLLDADERPVRHDLWRAVLDDEALLAAVRVVVGVADQPE"
     gene            complement(14861..15448)
                     /locus_tag="C6W96_RS20020"
                     /old_locus_tag="C6W96_19990"
     CDS             complement(14861..15448)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009066191.1"
                     /locus_tag="C6W96_RS20020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_19990"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_107412671.1"
                     /transl_table=11
                     /translation="MTPSTADHAPQAQMSVEEFEQLARTSPETVTLELINGKLEVKPVP
                     DGDHDEIIMWVAMQCMQQQPELRLYRERGLRIGGYRSGRARPDGTLARAGRFAGDGEWS
                     SPDHILMTVEVTSHDHDTDTRDRTEKRDGYAAASIPVYLLIDRDHDTLVVYSEPEKGRY
                     RHRTTYAYGDTVPLPGPVDITLESEELKNYSG"
     misc_feature    complement(15578..15596)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.15"
                     /tool="antismash"
     misc_feature    complement(15579..15595)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 24.96"
                     /tool="antismash"
     misc_feature    complement(15589..15603)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.47"
                     /tool="antismash"
     gene            15661..16110
                     /locus_tag="C6W96_RS20025"
                     /old_locus_tag="C6W96_19995"
     CDS             15661..16110
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C6W96_RS20025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C6W96_19995"
                     /product="N-acetyltransferase"
                     /protein_id="WP_325048191.1"
                     /transl_table=11
                     /translation="MTHTTSSPAKPSAELSFRRAGESDLAELVRLRDDAASWQIARGID
                     QWKPGELGPEHFGARLRAGEVWIATAGPGGPSAGAWELWWDDEPAWGVQPPVAGYVHRL
                     MTDRRTAPPGAGRALLAEAERRIAASGRPLCRLDCLTSNTRLRRY"
     misc_feature    complement(16268..16283)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            16366..16866
                     /locus_tag="C6W96_RS20030"
                     /old_locus_tag="C6W96_20000"
     CDS             16366..16866
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489040.1"
                     /locus_tag="C6W96_RS20030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_20000"
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_065487879.1"
                     /transl_table=11
                     /translation="MTVEEFEEFYAQAVARLTGQLYVMTGDLQEAQDVVQEAFVKAWVR
                     RGRLERDGQPEAWIRTVAWRLAVSRWRFRRRSADAWGRGSGGAEHVAPPDPDHVVLVDA
                     LRELPAQQRRTLTLHYLCDLTVEQIAGETGLSTSTIKTHLVRGRAALAHRLRDPRIEEA
                     PDV"
     misc_feature    complement(16381..16394)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     gene            16859..17353
                     /locus_tag="C6W96_RS20035"
                     /old_locus_tag="C6W96_20005"
     CDS             16859..17353
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126494.1"
                     /locus_tag="C6W96_RS20035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_20005"
                     /product="hypothetical protein"
                     /protein_id="WP_107412672.1"
                     /transl_table=11
                     /translation="MSEPRDPKGPEEPQDPLRSLFREAGEFGQALTAPETAAGITRRGM
                     RAQRRRMAVVAVGVCLVVGGGGAVAVGLLPVRPQPVAPATSPSPSYPSPVPSEGLPTEP
                     PSPPPSPSTTMPGSTGTEGPSGRTTEPGGPPTPTRTSTRTTPPTATATASATTDGGAST
                     P"
     gene            17465..18685
                     /locus_tag="C6W96_RS20040"
                     /old_locus_tag="C6W96_20010"
     CDS             17465..18685
                     /GO_function="GO:0000009 - alpha-1,6-mannosyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0004376 - glycolipid mannosyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006506 - GPI anchor biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010055996.1"
                     /locus_tag="C6W96_RS20040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_20010"
                     /product="mannosyltransferase family protein"
                     /protein_id="WP_107412673.1"
                     /transl_table=11
                     /translation="MSTLTPGLRPSPVRPPVPAAPEPRAARFRLSPADRDVLWLYLLTR
                     ISLWITAHFARWLFPAQSGVRETAPVLAPFQRWDANHYLHIARDGYFPAGTGPWTSGWD
                     NREAFFPGYPLLLRAVHTVVPDWTAAGLLISLLAGAVAVLALARVARAYLPEEGAGHRT
                     VVLFLLSPCAVFLAAGYTEALFLAFALPAWLAAMRHRWALAAVLTTLGTAVRVSGLFLA
                     AAIGLLFLLSARAGGGRRTWRSAGWTLLPALPPAAYSWYLHAHTGDWMAWKHAQERGWY
                     RTFHPPWEAWANTWTGAFGGTQSTGYAFMFQAELAAMLVGLALVALLVRRRRWPEAVYV
                     ALSLWALGTSYWYTSVPRATLLWWPLWIGLAALSLRRPWFRTAYLCVVAPVTTLVALTF
                     LTGRWAG"
     gene            complement(18728..19306)
                     /locus_tag="C6W96_RS20045"
                     /old_locus_tag="C6W96_20015"
     CDS             complement(18728..19306)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010981641.1"
                     /locus_tag="C6W96_RS20045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_20015"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_107412674.1"
                     /transl_table=11
                     /translation="MSVQERKKRERASRERLIVATARELAEQQGWDAVTTRRLAERIEY
                     SQPVLYSHFRGKREIIGAVALEGATEMAAALRAATSAADGHRAQVAALAHAYLEFAERN
                     PAVYDALFQLDGGLAFAREDTPEPLKDAFAALLETLGEVAGEGVHPALFTELFWSALHG
                     LATLTRAGRLLPEGAGERLDLLVERLAVL"
     misc_feature    complement(19289..19300)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            19398..19844
                     /locus_tag="C6W96_RS20050"
                     /old_locus_tag="C6W96_20020"
     CDS             19398..19844
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123677.1"
                     /locus_tag="C6W96_RS20050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_20020"
                     /product="DUF1772 domain-containing protein"
                     /protein_id="WP_107412675.1"
                     /transl_table=11
                     /translation="MLDALGIVTTVIVGLLVGVEFSVAFVINRILDALPDDSAQLGRSH
                     GGRMLGALMPFWYIGSLVLSAIWAVAGWGEGGAGLVVAAGGLLLLSVVMSLLLLVPINN
                     RGKRWTPENRPEDWKEQMNRWDRYHYVRVAVLIAAFASLAAALA"
     gene            complement(<19923..20171)
                     /locus_tag="C6W96_RS20055"
                     /old_locus_tag="C6W96_20025"
                     /pseudo=""
     CDS             complement(<19923..20171)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019435904.1"
                     /locus_tag="C6W96_RS20055"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_20025"
                     /product="MarR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVTAVQVGVAQDLAALGLPEPDYEVLSTLSEREDGTSTLREQAAK
                     MGWSRSRLSRHASRMEARELIRRAPDPTDGRGCLLVLT"
     gene            complement(20273..20482)
                     /locus_tag="C6W96_RS20060"
                     /old_locus_tag="C6W96_20030"
     CDS             complement(20273..20482)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126499.1"
                     /locus_tag="C6W96_RS20060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_20030"
                     /product="hypothetical protein"
                     /protein_id="WP_107412676.1"
                     /transl_table=11
                     /translation="MNSQVFDLMWGGVALVGGALLATNVRGAADRFQAMSYAYRSWPSS
                     VITCRVIGGVFALAGAGVLVDAGL"
     gene            complement(20485..21480)
                     /locus_tag="C6W96_RS20065"
                     /old_locus_tag="C6W96_20035"
     CDS             complement(20485..21480)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388482.1"
                     /locus_tag="C6W96_RS20065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_20035"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_234389348.1"
                     /transl_table=11
                     /translation="MSNQSVAAGVGLAGVMAHCGGSPVGAVELLVGAIASAPAAPEPYA
                     ALAELWQDRRSDGLKESLEESGSLSAVPAQAYFLFLEGDMDNAVMALGSVTGVRPDVAW
                     GAAPWFGDARFLGAVSAAALAEACLRTLDYGRDLDSDAMRKRFAPWFHALDVVSERDPV
                     PESLAAMARLPRACGRYELSFALCDRADAVDPVMWTALARAATWRATGNLDQSAAAFER
                     ALLLDPANWSLYLDLADLRAEQGDFAAAASLVDQGLEHEPGEVTLLAASAAYRTRLVGS
                     ADDLKALIALAPSLASTTYRNLLIDYACAGPQLPPELVAEARRIQKGQNG"
     gene            complement(21501..22517)
                     /locus_tag="C6W96_RS20070"
                     /old_locus_tag="C6W96_20040"
     CDS             complement(21501..22517)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126501.1"
                     /locus_tag="C6W96_RS20070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_20040"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_107412678.1"
                     /transl_table=11
                     /translation="MATPHFSSALPVPAVSPAYPMAKPGYGKRSAPGQQPRTREDFALL
                     PTRERYVAGFVDHLPDGAEMSVKQLAKQLPLYGQQAISTVLNALSVAGHLRRVRCSVGA
                     GDECRWVFRTFWSRTARDNEWWNAYLATEDATRATGPTATPEAPASPDLAAPAEPPALA
                     PVPHQRTPPQTPATESAPPTREAAPSAAYLALARLGRDDHRLGLSADDCTTLEPLAAKW
                     LDRGVTADYLTSTLTAGLPAQVDSPVGLIRRRLIDKLPPRLPATPSTAANTPTPTRRLL
                     AECTDCGRPGPPEALPDGLCHPCHTTHTAGGRPTPDPTQIAAVKAHMANLRTLLKPV"
     misc_feature    22699..22714
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.53"
                     /tool="antismash"
ORIGIN
        1 gctcgtccag gaggagcagg tcgggccgct tgccgaaggc gagcgcgaag gccacccggg
       61 tgcgctggcc gccggagagc gtgccgatcc tcgcgtccgc cgggacgttg cccgcgcgga
      121 cgatccgttc cgccgcggcc gcgtcccagc cggggttcag ctcggcgccc atccgcagcg
      181 tctcggccac ggtgaaccgc ttgaacagcg gcttgtcctg gccgaggaac gcgacctggg
      241 gcagtacggc ggggtcgtcg accggtacgc cgaagacgcg caggtcgccg gtggtcggct
      301 gcacctgacg ggtcgccagc ccgagcaggg tgctcttgcc ggctccgttc gggccgacca
      361 gaccgcagat gcggccggcc gggatccgga aggagcagtc gcgcagcgcc cagccgcgcc
      421 ggtagcgctt gcccaggcct cgggcctcca gggcccagtt gccggacgtc gcgttcgggg
      481 tgctcgtgtc tgccacgcgc ctcacctcgg ttccgtgatc cgtgatcgtg attccatgaa
      541 tcaattaatg gaatcatgga gtcgtgaggg aatgactgtc aagccggggt ggtggggtgc
      601 gcgccgccag ggcgccgggc cggcacgctc gtgctccctc cgcccagggc ataggctcgc
      661 cccatgggca gtcacccgga acgtcttccg aacccgacca ccccggccgg ccgcgagggg
      721 ctcgacgccg tgctcgcccg gcccgaccgc gcggtcgtcg ccctcgactt cgacgggacg
      781 ctcgccgaca tcgtcccgga ccccgaacag gcccgcgccc accccggcac cgtcgaggcg
      841 ctcgccgcgc tcgcgccgaa ggtcgccgcc atcgccgtga tcaccgggcg cccggcgggc
      901 gtcgccgtgc ggtacggcgg cttcgcgggc gtccccggtc tggagcacct cgtcgtgctc
      961 gggcactacg gggccgagcg ctgggacgcc gtgaccggca cggtccacgc ccccgccgcg
     1021 catccgggcg ttacggcggt acgcgccgaa ctccccggcg tgctgcatga gttcggggcc
     1081 tggagcggca cctggatcga ggagaagggg caggctgtcg ccgttcacac ccggcgggcc
     1141 caggacccgc aggcggcctt cgagtcgctg cgcgggcccc tcggggagct ggcggcgaag
     1201 cacgggctga tcgtcgaacc ggggcggctg gtcctggagt tgcgcccgcc cggcatggac
     1261 aagggcgtcg cgctcgccgg gttcgtcgcg gagctggacg cggagtccgt gatctacgcg
     1321 ggcgacgacc tcggggacct cgccgcgttc gccgcggtgg agaagctgcg cggcgagggc
     1381 ccggacggca tccccggtct tctggtgtgc agcggcagtg ccgaagtccc cgaactggcc
     1441 gagcgcgccg acctgtcggt gcccggcccg gccgccgtgg tggacttcct ggcggctctg
     1501 gccgagcggc tgtaaannnn nnnnnnnnnn nnnnnnnnnn ngcctccagc tggtccagga
     1561 accaccgctg cggcggcagc gcggtcgccg cctccgccag gcgcttcgtg cggcccgacc
     1621 gctcgtcgcc gctcatcgtc agcgcctcgt gcagcgcctc cgccgtgccc gtcacgtcgt
     1681 acgggttcac cacgatcgcg tcctcgccca gctcctcgta cgcccccgcc tcccgcgaca
     1741 gcaccagcgc gcagccctgg tccgagacga cggggacctc cttcgcgacc aggttcatgc
     1801 cgtcgcggat cgggttgacc agcgccacgt ccgccagccg gtaggcggcc agcgagcggg
     1861 cgaagtcgtc cttgacgtgg aggacgaccg gggtccagct ctccgtgccg tactccccgt
     1921 tgatctccgt ggccagcgac tggaccgccg ccgtgtagtc ccggtagacg gcgaggtcct
     1981 ggcgggaggg gtaggcgaag gcgatatgga cgacgcgctc gcgccactcg gggcgggtct
     2041 ccagcagggt ccggtacgcg tgcaggccgc gcacgatgtt cttggacagc tcggtgcggt
     2101 ccacccgcac gatcgtcttc cggttctcgc ccacctgctc gcgcagcgcc gccatccgct
     2161 cgtccacgtc cgcctcgtgc gagcgccggc gcaggaagtc cgcgtcggcc ccgaggccgt
     2221 gcacgccgat cctggtgcgg cccgtgccgc cgaggatctc cgtacagcag ccgatgaacg
     2281 cgtccgccca gcgccgggtc aggaacgcgg cccggtccgc gccgaggatg ccgcgcagca
     2341 gctgctcggc gatgtcgtcg ggcagcagcc ggaagtagtc caccggggcc cacggggtgt
     2401 gcgagaagtg gccgatccgc aggtccgggc gcagtccgcg gagcattccg gggaccaggg
     2461 ccaggtggta gtcctggacc aggaccgccg ccccttcccc cgcctcctgg gccagcgcct
     2521 cggcgaaggc ccggttgtac gtctcgtacg cggcccactg ccgccggaac tccgtgtcga
     2581 agaccggctc gaccggggtc tggtacagca ggtggtggac gaaccacagc acggagttcg
     2641 cgatgccgtt gtacgcgtcg gcgtgcacct cggcgtcgat gtccagcatc cggacgcccg
     2701 gctcgccgac tccgcgccgc accgcctcgc ggtcgccgtc gccgagtgcc gcgcacaccc
     2761 acagcttgtc gtcgacggcg ctcaggccgg agacgagacc gccgccgccg cgcttggcgt
     2821 cgagcgtccc gtcctcgccg agcgtgtacg tgaccgggcc gcggttggac gcgacgagga
     2881 cctgggcgtt cgaggaagtc gtgtgctcgg agaccatgta gcggaaccta gcccgttcgg
     2941 gaagccgcca aacgcgcgtc cgggggacca ccggtcacgg cctcggtcgc gccccccctc
     3001 acgccgcccg ctcacgccgc gtggcgctcc gcgtactccg cgatctcccg catcggcggc
     3061 cgctcctccg tgtccaccgc atgggtgcgc ggcacgaagc cgtcctcgcc gcgctcgaac
     3121 tgggtcagta ccggccgcac cagatggccc cgggagagcc gcagctgggc cgtgcggtag
     3181 atcgccgccg ccatccggcc cagcgcctgc ccgtcctggt ggcggtggac gcgtacaccg
     3241 acgtctacct ggcccagcgc gtccaggccc accgtgtgca gcgcgtcgac cagcaggccc
     3301 agctccaccc cgtaaccgac cgggaacggc agccgctcca gcagggaccg ccgcaccgcg
     3361 tactcgccgc ccagcggctg gacgaaaccg gccagctgcg gccagtgcag attgagcagc
     3421 gggcgtgcca ccagttcggt gacccggccg ccctgacctg ctctgccgcc gagcgggcgg
     3481 tcgtacatcg ccttgacgaa ctggaccgcg gggtcggtga gcagggggcc gaccgtgccc
     3541 gagacgaagt ccgccgagaa gtccttgagg tcggcgtcca cgaagcagac gatctcgccg
     3601 ctggtcacca ggagtgaccg ccagagcacc tcgcccttgc cgggcagggc cgggatccgg
     3661 ggcaggatcg cgtcccggtg gaccacgcgc gcgcccgccg cccgggctac ggcggcggtc
     3721 gagtccgtcg aaccggagtc gatcaccacg agctcgtcga ccagccggac cttctccatc
     3781 agctcgcggc ggatcaccgc cacgatcgcg ccgaccgtgg cctcctcgtt cagcgcgggc
     3841 agcaccacgc tcacggacgt acggcgcggg tcggcggccc gggcgtcggt gagccggttc
     3901 agcgggcggt cgccggacga ccaggaacgc ctggtcagcc agcgttccac ctcttcgagc
     3961 acggtcggca ctccctgtgt gtgatccatc tcgcggttcg gacgactatc tcaacggtcc
     4021 ggtgcttcgg ttacagtctt gaacaacgcg gatgaccctc gcatgtcggg gtcggagcgc
     4081 acataaacgc ctggatcgaa gatccagcgc catagagctc atccagaggg actgagggaa
     4141 cggcccgttg aagtcccggc aaccctcctg ccgaccgcga ggtcacggtg gggaaggtgc
     4201 caattccgtc ttgcggcgaa atgcgtcgcg aggaagatga ggagaaaggg cctccgccat
     4261 catggctgtt cagaccgtcg caggtaatgc caccaccgct tccccggacc tgggtcccgc
     4321 cgcggcgctt tcctgccgcg agtgcggcga gcgtttcgag ctcggccccc ttttcgcctg
     4381 tgcgtcctgt ttcgggccgc tcgaagtggc ctacgacctg cccaccggct cgcccgaaga
     4441 gctgcgcaag cgcatcgagg ccggtccgga caacatctgg cgctacgccc cgctgctgcc
     4501 cgtccccgcc gacgtcgcgg acaagcccaa cctgaacccc ggcttcacca agctggtcaa
     4561 ggccgacaac ctcgcccgtg agctgggcgt caccggcggc ctgtacgtga aggacgactc
     4621 cggcaacccg acgcactcct tcaaggaccg cgtggtcgcg atcgccgtcg aggccgcccg
     4681 cgccttcggt ttcaccaccc tctcctgctc ctccacgggc aacctggccg gagccgtcgg
     4741 cgccgccgca gcccgcgccg gactgcgctc ctgcgtgttc atcccgcacg acctggagca
     4801 gggcaaggtc gtcatggccg cggtgtacgg cggtgaactg gtcggcatcg agggcaatta
     4861 cgacgacgtc aaccgcttct gctccgagct catcggcgac ccgctcggcg agggctgggg
     4921 cttcgtcaac gtcaacctcc gcccgtacta cggcgagggc tccaagacgc tggcgtacga
     4981 gatctgcgag cagctcggct ggcggctgcc cgaccagatc gtcatcccga tcgcgtccgg
     5041 ctcccagctc acgaagatcg acaaggggct ccaggagctg atcaagctcg gcctggtcga
     5101 ggaccggccg tacaagatct tcggcgccca ggccgagggc tgctccccgg tctccgccgc
     5161 cttcaagggc gggcacgacg tcgtccggcc ccagaagccg aacaccatcg ccaagtcgct
     5221 ggccatcggc aacccggccg acggccccta cgtcctcgac atcgcccggc gcaccggcgg
     5281 cgccgtggag gacgtcaccg acgagcaggt cgtcgacgcg atcaagctgc tggcccgcac
     5341 cgagggcatc ttcggcgaga cggcgggcgg cgtgacgctc ggcgtgacga agaagctcat
     5401 cgaggccggt gtcatcgacc cgacgctcac caccgtcgtc gtcaacaccg gtgacggcct
     5461 caagacgctc gacgcggtct ccgccacctc gcaggccacg gccaccatca agccgagcct
     5521 ggacgcgttc cgcgccgcgg gcctcggcac cgcctgacga ccaccccgta ccgaaggaag
     5581 agaagaaggg caccaccatg agcgtcaagg tccgcatccc caccatcctc cgtacgtaca
     5641 cgggcggcca ggccgaggta ccggcggagg gcacgaagct ctccgaggtc atcgagtccc
     5701 tggagaagga ccacccgggc atcgccgccc gcgtcctgga cgatcagggc aagctgcgcc
     5761 gcttcgtgaa cgtgtacgtc aacgacgacg acgtgcgctt cgaggggggc ctggacgcgg
     5821 ccaccccgga cggcgccggc gtctcgatca tccccgcggt ggccggcggc tgctgaaccg
     5881 cccgggccgc tcccggcggc ccacgccgga tccccaccgc acctctgtgt gacccctgtt
     5941 gccccctccg cgagagaagc ggagggggca attctgcatg gttgagcgcg gtacagttgg
     6001 ggaagcccca tccgctgccc gtgccgcccg catatgagaa tgcgcccggc tccgataaga
     6061 agcagccaaa gtacctgaac ctcttgcggc ataagtgccc tttgcctggc ccgacttgcc
     6121 cgtaaatctc agcaaacccg cattttcgcc tgttcctctg cgcccagaat tctcgtccga
     6181 ttgacctgtt gcagagggca gttggacgga tacattcggc cgcggtcgac gcgctgcggc
     6241 gctgcgcacc ctctcctgtc ggagggtgag tcacgacccg gggccgcgaa gtgcggtcct
     6301 gcgcaagggc cagtaatagg ggagttgggc atggctcagg gcaccgtcaa gtggttcaac
     6361 gcggagaagg ggtacggctt catcgcggtc gacggtggtg cggatgtttt cgtccactac
     6421 agcgcgatcc agatggacgg gtaccgcacc ctcgaagagg gtcagcgagt tgaattcgag
     6481 atctcgcagg gccagaaggg gccccaggcc gacatggtca agctcgccgt cggctgagct
     6541 cggcgcggtc gtccgacgac accactcacg cacgtagggc ccgaccccgg gatcagggga
     6601 tcgggcccta cgcgcgtccg gtggccgggg ccctgtgcgc gtccgggagc cgaccacgcg
     6661 ccgaccgtgc gccgaccgtg ctccgcgccc tcggccgcat ggcgggcacc gacgagaggc
     6721 gcttgcactc tcgggggtcg agtgctaatc attggcgtta gcactctcca ggtgagagtg
     6781 acagaacttg gaccgggccg gtgaggcccg caggtgtgac ggggcaagga accgtcacac
     6841 gcgcaggccg tccgtcgcgg gcgcctcccg gtccggagaa atccacccct gtccgggagg
     6901 accacttcac atggccaaga tcatcgcgtt cgacgaggag gcacggcgcg gtctcgagcg
     6961 cgggatgaac cagctcgccg acgccgtcaa ggtcaccctc ggccccaagg gccgtaacgt
     7021 cgtcctcgag aagaagtggg gcgcgcccac gatcaccaac gatggtgttt ccatcgccaa
     7081 ggagatcgag ctcgaggacc cgtacgagaa gatcggtgcg gagctggtca aggaggtcgc
     7141 caagaagacg gacgacgtcg ccggcgacgg tacgaccacc gccaccgttc tcgcccaggc
     7201 gctcgtccgc gagggtctgc gcaacgttgc cgccggcgcc aacccgatgg ccctcaagcg
     7261 cggtatcgag aaggccgtcg aggccgtctc cgccgctctg ctggagcagg ccaaggacgt
     7321 ggagaccaag gagcagatcg cttcgaccgc ctccatctcc gccgccgaca ccgagatcgg
     7381 cgccaagatc gccgaggcga tggacaaggt cggcaaggaa ggcgtcatca ccgtcgagga
     7441 gtcccagacc ttcggtctgg agctggagct caccgagggt atgcgcttcg acaagggcta
     7501 catctcggcg tacttcgcca ccgacatgga gcgtatggag gcgtcgctcg acgacccgta
     7561 catcctgatc gtcaactcga agatcggcag cgtcaaggac ctgatcccgc tgctggagaa
     7621 ggtcatgcag tcgggcaagc ccctgctgat catcgccgag gacgtcgagg gcgaggcgct
     7681 ctccaccctg gtcgtcaaca agatcaaggg cacgttcaag tccgtcgccg tcaaggcccc
     7741 gggcttcggc gaccgccgca aggccatgct cgcggacatc gccatcctca ccggcggcac
     7801 cgtgatctcc gaggaggtcg gtctcaagct ggagaacgcc ggcctggacc tgctcggccg
     7861 cgcccgcaag gtcgtcatca ccaaggacga gacgacgatc gtcgacggcg ccggtgacag
     7921 cgaccaggtc cagggtcgcg tcaaccagat ccgtgccgag atcgagaact ccgactcgga
     7981 ctacgaccgc gagaagctcc aggagcgcct cgcgaagctg gccggcggcg tggccgtcat
     8041 caaggccggc gccgccaccg aggtggagct caaggagcgc aagcaccgca tcgaggacgc
     8101 ggtgcgcaac gccaaggccg ccgtcgagga gggcatcgtc gccggtggtg gcgtggctct
     8161 gctccaggcc tcggccgtct tcgagaagct cgacctcacg ggcgacgagg cgaccggcgc
     8221 caacgccgtg aagctcgcgc tggaggcccc gctcaagcag atcgccgtca acggtggtct
     8281 cgagggtggc gtcgtcgtgg agaaggtccg caacctgccg atcggtcacg gcctcaacgc
     8341 cgcgaccggc gagtacgtcg acatgatcgc cgagggcatt ctcgacccgg cgaaggtcac
     8401 gcgctccgcc ctgcagaacg cagcgtccat cgccgcgctc ttcctcacca ccgaggccgt
     8461 catcgccgac aagcccgaga aggccggcgc ggccgctccg ggcggcatgc cgggcggtga
     8521 catggacttc tgatcggttc cggctccgcg ccggtcgatc gaggttccgc gtacgccgag
     8581 tacgtccagt acgtcgagtg cgcaggtacg tcccacaggg gcggtatctc cttcacggag
     8641 gtgccgcccc tgtggcgtgt tcacggaggt gccgcccctg tggcgtcccc ggcgggccgg
     8701 ggacaatggg gcgagggcgt ggtcgtacgg acacgggggg cgggacgggc atgagcgtga
     8761 gtgctacggg gagaacgggc ggccgagggc ggctcaaggg ggtctcgctc gtcgtgggcg
     8821 gggccgtgct gctcgtggtg gggctgttcg ccgtggtgac cgggacgggc ctctccggtg
     8881 tcgtcggcat gcgggtggag accttcggcc gtatcgagtg ccacgacgtc cggaccgaga
     8941 agggccagac cgtctggcac tgctccggcg agagcgccgc ccagcagcgc gccaacgcgg
     9001 ccgagcgcga ccgggcggcc cgggaggccc tgcgcgccca tgtggacggc atgccccggt
     9061 ccgcggagat cagccgcagc aggatcctct tcgccgacca cgacggccgg accgaccccg
     9121 aaaccatcac cgcgacccag gtgttcgacg gcggacgctg gtacgcccac tcctcgatgc
     9181 tcgtcggcta cggcatgatc ccgctgcttc tgggcgcggg aacggcggcc tggggcggct
     9241 acctgctgcg caagaggtag cggacagggg gcgcgcgggc ggttgcgggg gcgctgcggg
     9301 ggcgttggcg tggccgaatg actacttgcc gtggccactc ccgtacggca gcacgtttcg
     9361 gggcggctgt accgagggcg gtggcgcgca cgcggtgtct ggggtagggc ggtcgtggag
     9421 ccgttcaggg gcccgctcgc ggctggttcc ccggttcccg gtactgtcct tcctctcttg
     9481 ccagctcact gcccggtccg gcgaccgcat gcagccattg gtccagtcca ccgggtcgtc
     9541 tcggcggggt ggtgtgcgac tgcacagggt ggccggccgg gcggccgacc ccgggcggag
     9601 gcgtcccgga ccggcccgcg acgcacctcg ccgctcgcgc tatccggcca acttcatggg
     9661 gtaagtcgga atcatgcgta ccggttcgac ggccggacat gatggctctg gtgttcgcat
     9721 gacgaacacc agttgcaaca ccactcgcac caataactcc agttatgcag acgtcagttg
     9781 ggcataacgg tcgtcaacca cacagaaggg aaggtgtcat gaagcagcag aagcagcaga
     9841 agaaggctta cgtgaagccg tcgatgttcc agcagggcga cttctcgaag aagaccgccg
     9901 gctacttcgt cggctcgtac aaggagtact ggagccggcg gatcatctga tccgccgatc
     9961 cgattcctgt gcaccgcgtg agaacttccg aaaggtgaag atgcccggcc agttgcgtga
    10021 ctacttcgtc gtcctgccgg acagcgcggc gggagcggca gcggccgggc ggcttcccgt
    10081 accgggagcg gctgccgggc ggtccgccgc gccggacgcc accgggtccg cccgggaggt
    10141 gggcggcgcc ctgaccgtcg cccacccctc gggccggccc tggatcgtcg cccgaccgct
    10201 ggtccgcaag gtcagccatc tcgcccgggg cgaggacgcc ctcgtcctca tcggcccgga
    10261 ccgcgtcccc gacgccgtgc tcgccgggat cctggagggc gcccgcgacc ggaccggcct
    10321 ggaacaccgc ctcgcccggg tgcccggcct ctaccacgtg gtcgcccggc tgtccgggcg
    10381 gagctggatc cggggcaccg ccaccggact ccgccggatc taccacgccc ggcacccggc
    10441 ggccggaacc atcgcctccg accgtcccgc cgtcctggcc cacctgatcg acgcgcccct
    10501 cgacgagagc gccttggcgc tgcggctgct ggacttcctg ccgcaccccc tgagccgccg
    10561 tcccgtgtgg cggggcgtcc acgagaccgg tgccgggtac ggcctggccc tgcccgtcgc
    10621 agcaccgggc acggccgccg tccccggtcc cacggagcac cgctggtggg agccgccgcc
    10681 cggcgaactg cccctggcgg agggggcccg cgaggtcggg gacgccgtcg cggcctccgt
    10741 acgggcccat gtcggcggcc tggaccggat cagctgcgaa ctctccggcg gactggactc
    10801 caccgccctc gccttcgccg cccgcgatac gggccccgcg tcgctgtccc tgctgaccgt
    10861 ggccgcccgg gaccgctaca gcgaggacga gacctgggcg cgccgagcgg tcgaggcggc
    10921 aggcggcacg gccgcgccgg gcggggggtg tggggccgcc cccgccctgg accaccacct
    10981 catccccgcc gccgacgccc cctacttcta cgccgatctc gcctccaccg ccgccgagtt
    11041 gaacgacgaa ccgctccccg tcgcccccgg ccgggcccgc gcggcgctgc tcctcggccg
    11101 cgcccgcgcc accggctccc gctaccacct caccggctac ggcggcgacg agatcttcct
    11161 cggcctgccc cacgcctacc aggacctctt ccacggcaac ccgttcaccg cctggagcca
    11221 cctcggcggc ctgcgccacc agctcggctg gccgctcctg cccacggtga aggccctgct
    11281 cgaccgttcg gcgttccccc gctggctcgc cggggcggtc accgccgcac cccagcccgt
    11341 cgcccggacc ccgctgctct cctggggcgt acggcagtcc ctgcacccct ggctcaccga
    11401 gcacgcgacc actctgatcg ccgaggagtt ccgggccgcc gccgagcacg ccgaaccgat
    11461 cgacccgtgg cggggccggc acgtcgacat cgacggcgta cggatgggag cccggcactt
    11521 ccaggcgatg gaggacatcg gcatgacgat cgggctgccg gtcgccgcac ccttctacga
    11581 cgaccggatc ctggaggcga ccctcgccgt acgcctgccg gagcgcatca gcccctggcg
    11641 ctacaagccg ctgctcgtcg aggcgatgcg cggggtggtg ccggacgcgc tgccggcccg
    11701 gacgacgaag gaccacatgg cctccgacga acaccagggc ctgcgcgaac acgccccgga
    11761 actcgccgag ttgtggaccg gatcccgcct cgccgaacac ggcctggtgg actcgcgcca
    11821 gcttctccga ctggcggccg aacccttctc gccggtcctg gtcgaacact ccatcagctc
    11881 caccgtggcc ggggagacct ggctccgcac ggccgagaac gcctggcccg caccccagtt
    11941 gaccctctga cgaccaccac ccccagcgag gcatccctgt gaagctcaga aaaggcatcg
    12001 ccgtcacgac caccgagtac ggcggcgtcc tcctcgacga gaagagcggc agctactggc
    12061 agttgaacga caccagcgtc atcgtcgtcg agaccctcgc ggcgggccgc gcccccgagg
    12121 ccgccgtcga gcggatcgtc gccgagttcg acgtcgagcg ggccgaggcc gagtcggacg
    12181 tcgcggagct gacccgccgg ctcgtcgagg cgaagatcct gcgcccatga ccaccgagat
    12241 gacgatgccc cgccggggcg ctggagcggg cgggacacgt ctgcgcgccg ccatcgccgc
    12301 cgcgttcgtc ctggcccggt tcaagcccgg ccggctgcgc cgggtgctgg cccggtgcgc
    12361 ccggggcgcg cgcccggcct cgtacgccga gacgctggag gtgctggagg cggtcaccgc
    12421 caccagccgc cgctgcgcga gccgttacgg ctgcctgccc cgctcggtgg ccgtcgccct
    12481 ggcgtgccgg atgtccggcg tctggcccga ctggtgcgcg ggggtgtggg cgaccccgcc
    12541 gttctccccg cacgcctggg tgctggcgga aggacgtacg gtcggggagc aggcagaggc
    12601 cgccgatctg cgtcctttga tggtggtgac ggtacgcgag ggggttcagg gtgagcgcgg
    12661 tggcggggac gacggcgggg gcgggacagg cggatccggg cccgggcccg gtcccggaac
    12721 cgggcagacc gcctgagagc acggaacggc ccggcccgga atcaccggac cggaccccgc
    12781 ttgccccggc cgccccctcc acgcccccac ctgcctcaag cccgtcccct ctccgcctgc
    12841 tcctggcccg ggtccgtccg caccggggcg tcctgatccg ggcgggcctg ctctcgctcg
    12901 ccgggtccgg ggcgggtctt gcgatgccgc tgatggcgaa gcacgcggtg gacacgttcg
    12961 ccgacggccg ctcgcccgtg gccccgctcg tcgcgctgac cgcgctcgtg ctggccgggg
    13021 cctgcctgtc cgcgtacggg agctttctca tgtcccgtac gggagaaggc gtcgtcctgc
    13081 gcgcccgcga ccaactggtc ggccgcatca tgcggttgaa ggtcccggcg gtggaccggc
    13141 tgacgcccgg cgacctccag tcacgggtca cgagcgacac gaccctgctc cgtacggtgc
    13201 tctccagcgg actcgtcgaa tcgttcaaca gcgtcctgat gctgctgggc accatcgccc
    13261 tcatggcgta catggacctg acgctgctcg gcgtgacgct cgtggtcgtc gtcggcatcg
    13321 gggccgtgac gtccctgctg atgccgcgca tccagcgggc gcagctcaag gcgcaggagt
    13381 ccgtgggcgc gatgggcgcg gccctggacc gggtgctcca ggcgttccgt acggtcaagg
    13441 cgagcggggc ggaggagcgg gagacggcgg cggtcgcggc ggcggcgcgg catgcgcacg
    13501 accggggcgt gtcggtggcg aagtgggcct cggtcaccga ggtcacgatg acgatgtcga
    13561 tccagctggc gttcctggcg gtgctgggcg tcggcggcgc gcgggtcgcc tccggttcgc
    13621 tggagatctc ctccctgatc gcgttcctgc tgtacctctt ctatctgatg ggcccgatcg
    13681 gcggtctggt cgagggctgg acgggcctgc agagcgggtt ggcggcggtg cgcaggatcg
    13741 acgaggtgga gtcgctgccg ggcgaacctg cggatagatc cggcgggttg aagaaaaaag
    13801 gggacggcgg cccgctcggg gtcaccttcc aggacgtgac cttcgggtac ggggacgagc
    13861 gcgcccccgc ccaccagggg gtgacgttcg acgtgccggc cggcggaatg gtggcgctgg
    13921 tgggcccgtc cggggcgggc aagtcgacgg tgttcagcct gctggaacgc ttctacgacc
    13981 acgaggccgg cacgatcacc gtgggcggcc gggacatccg cgactggccg ctcgccgagc
    14041 tgcggggctc gctggcctac gtggagcagg acgcgccggt gctggccggg acgctgcggg
    14101 agaacctcct cttcgccgcc cccgacgcag aggagaagga gctgacggcc gcggtcgccc
    14161 gcacccggct ggacgccctg gtcgagcggc tgcccgaggg cctggacacg gcggtcggcc
    14221 accggggcgt caccctctcc ggcggcgaac gccagcgcat cgccatcgcc cgggccctcc
    14281 tgcgccaccc ccggctgctc ctcctcgacg aggtgacctc gcaactggac gcggtcaacg
    14341 agcaggcgtt gcgcgatgtg atcctcgaac tggcggagca gacgacggtg ttggtgatcg
    14401 ctcaccgcct gtccaccgtc cggcacgcgg accgcatcgt ggtcctggaa gagggccggg
    14461 tccgcacggc gggcacgcac gaggagctga tcgccgggga cgagctgtac cgcgagctgg
    14521 cgacgacgca actggcggcg gacgcgcggt gaggggcccg gagggcgcgg agggcgcgga
    14581 gggctcggac ggtgggtgtg gtgcgggcgc ggagctgagg cgtcggttcg ccgaggaggt
    14641 cgactggtcg aggatggtcg accctgccca cgatcgtcga cgccgttgag ttcctcgccg
    14701 aggtcgccac cgccgacccg gcgtgcgcgg cggaggtggc cccgcgggtg cggtacctgc
    14761 tcgacgccga cgagcgcccc gtccgccacg acctgtggcg cgccgtcctg gacgacgagg
    14821 cgttgctcgc ggcggtgcgg gtggttgtgg gggtggcgga tcagccggag tagttcttca
    14881 gctcctcgct ctccagagtg atgtcgaccg gaccggggag gggcacggta tcgccgtacg
    14941 cgtacgtggt gcggtgccgg tagcggccct tctccggctc gctgtacacg acgagggtgt
    15001 cgtggtcgcg gtcgatcagg agatagacgg ggatgctcgc cgcggcgtat ccgtcccgct
    15061 tctccgtgcg atcgcgggtg tcggtgtcat ggtcgtgcga cgtcacttcg acggtcatga
    15121 ggatgtggtc cgggctcgac cactcaccgt cccccgcgaa gcgccccgca cgggccaggg
    15181 tgccgtccgg gcgggcgcgc ccgctgcggt acccgccgat ccggagcccg cgctcgcggt
    15241 acagccgcag ctccggctgc tgctgcatgc actgcatcgc cacccacatg atgatctcgt
    15301 cgtgatcccc gtccggcacg ggcttgacct ctagctttcc gttgatgagc tcaagcgtca
    15361 cggtctcggg ggacgtacgg gcgagctgct cgaactcctc gacggacatc tgggcctgcg
    15421 gtgcgtgatc ggcggtgctg ggggtcatgg cgtcgcctcc tcccctccat cgtgccctgt
    15481 ccggtctgtg ggcgagctgc acagccatcg gtatgccctt tcggatcgtc acccatttgg
    15541 tccaggtgct ctgcacgcta gggtcccgcg accgtgtgtt gcaactcgat cgcaaattgt
    15601 caacttcgca gctggggagg gtagatagga cggcgaaacc tgttgaggga agatcacggc
    15661 atgacgcaca caacctcgtc tcccgcgaag ccgtccgccg agctgtcgtt ccggcgggcc
    15721 ggggagagcg acctggccga gctcgtacgc ctccgggacg acgccgcgag ctggcagatc
    15781 gcgcggggca tcgaccagtg gaagcccggg gagctgggcc cggagcactt cggggcgcgg
    15841 ttgcgtgcgg gcgaggtgtg gatcgccacg gcgggtcccg gcgggccgag cgccggggcc
    15901 tgggagctgt ggtgggacga cgagccggcc tggggtgtcc agccgccggt ggcgggatac
    15961 gtccaccgcc tgatgaccga ccggcgtacc gccccgcccg gagccgggcg cgcgctgctg
    16021 gcggaggccg agcgccggat cgccgcgtcg ggccgcccgc tgtgccggct cgactgcctg
    16081 acgtcgaaca cccggctccg ccgctactaa gaggaggcgg ggtacgtggt ggtcggcgag
    16141 caggcgggga agaacggcga cggcggccgg acgtacgggg tcacgttgct ggagaagcgg
    16201 ctgcgggagg gctgagaccc ggccgaacgg gggccgagac ggggctgagc aggggctgag
    16261 caggggctgt gacgaccgtc acccgcgatt cttcgtcggt ggtgtcgacc ggatgcccga
    16321 cggcgggcgt atacccggtg aaagcgaaag atccgggagc aacttttgac cgtcgaggag
    16381 ttcgaagagt tctacgccca ggcggtcgca cgtctcaccg gccagttgta cgtgatgacc
    16441 ggcgacctcc aggaggcgca ggacgtcgtg caggaggcgt tcgtcaaggc gtgggtccgg
    16501 cgggggcggc tggagcggga cgggcagccc gaggcgtgga tacgcacggt cgcctggcgg
    16561 ctggcggtga gccgctggcg tttccggcgg cggtcggcgg acgcctgggg ccgggggagc
    16621 ggcggggcgg agcacgtcgc gccgccggac ccggaccatg tggtcctggt cgacgcgctg
    16681 cgggagctgc ccgcccagca gcgacggacg ctgaccctgc actacctgtg cgacctgacg
    16741 gtcgagcaga tcgccgggga gaccgggctt tccaccagca cgatcaagac gcatctggtc
    16801 cgtggccggg cggcgctcgc ccaccggctg cgggaccccc gcatcgagga ggctcctgat
    16861 gtctgaaccg cgggatccga agggtccgga ggagccgcag gatccgttgc ggtccctgtt
    16921 ccgggaggcc ggggagttcg ggcaggccct gaccgccccg gagaccgcgg cgggcatcac
    16981 ccggcgcggc atgcgcgccc aacggcgccg gatggccgtg gtcgcggtgg gggtgtgcct
    17041 ggtcgtcggc ggaggcggcg cggtcgcggt gggcctgctg ccggtacggc cgcagccggt
    17101 ggccccggcc acgagcccgt cgcccagcta cccgtcgccc gtaccgtcgg agggcctgcc
    17161 gaccgagccg ccctccccgc caccgtcgcc gagcaccacg atgccgggga gcacggggac
    17221 ggaggggccc tcgggccgga ccaccgagcc gggcggaccg cccactccca cgcgtacgag
    17281 tacgaggacg acgcccccga cggctacagc gacggcatcc gcgacgactg acgggggcgc
    17341 gtcgacgccc tgacgccgcc gcgcggcctc ctccccaccc catcctcttc cgtgacccgg
    17401 cggtttcccg ggcgatccgg cgcgccccga cgtacctgcg aggcgcgccc gaaaggtgcc
    17461 tgcgttgtcc acgctcactc ccgggctgcg gccgtcccct gtgcgtcccc cggtccccgc
    17521 tgcccctgag ccccgggcgg cgcggttccg cctgagcccc gccgaccgcg atgtcctgtg
    17581 gctctacctc ctcacccgca tatccctctg gatcacggcc cacttcgccc gctggctgtt
    17641 ccccgcgcag tccggcgtac gggagacggc gccggtcctg gcgccgttcc agcggtggga
    17701 cgcgaaccac tacctccaca tagcgcgcga cggctacttc ccggcgggca cgggaccgtg
    17761 gacgagcggc tgggacaacc gggaggcgtt cttccccggt taccccctcc tgctccgcgc
    17821 cgtacacacg gtcgtgccgg actggacggc tgcggggctg ctgatctcgt tgctcgcggg
    17881 cgcggtggcc gtactcgccc tggcccgtgt cgcgcgtgcg tatctgccgg aggagggggc
    17941 gggacaccgt acggtcgtcc tcttcctgct ctcgccctgc gcggtgttcc tggcggcggg
    18001 ctacacggag gcgctgttcc tcgcgttcgc cctgcccgcc tggctcgcgg cgatgaggca
    18061 ccggtgggcg ctcgccgccg tcctgacgac gctgggcacg gcggtgcgcg tcagcggcct
    18121 gttcctcgcg gcggcgatcg ggctgctgtt cctgctgtcc gcccgggcgg gcgggggccg
    18181 gcggacctgg cggtcggcgg gctggacgct gctgcccgcg ctgcccccgg ccgcgtacag
    18241 ctggtatctg cacgcgcaca ccggtgactg gatggcctgg aagcacgcgc aggagcgggg
    18301 ctggtaccgc acgttccacc cgccctggga ggcgtgggcg aacacctgga ccggggcgtt
    18361 cggcggtacg cagtcgaccg gctacgcgtt catgttccag gcggagttgg cggcgatgct
    18421 ggtgggtctg gcactggtgg cgctgctggt acgccgacga cgctggccgg aagcggtgta
    18481 cgtggccctg agcctgtggg cgttgggaac gtcgtactgg tacacgtccg tcccgcgcgc
    18541 gacgctgctc tggtggccgc tgtggatcgg cctggcggcg ctgagcctgc gtcggccgtg
    18601 gttcaggacg gcgtacctgt gtgtggtggc cccggtgacg acgctcgtcg cgctgacgtt
    18661 cctgacgggg agatgggcgg ggtgaggagc gggccgaccg ggccggtggc tgctgccgga
    18721 gtacgtatca gagcacggcg agccgctcca ccaggagatc cagccgctcc ccggcgccct
    18781 ccggcaggag ccgccccgcc cgggtgaggg tggccagccc gtgcagggcc gaccagaaga
    18841 gctcggtgaa cagtgccggg tgtacgccct ccccggcgac ctcgccgagc gtttccagca
    18901 gcgcggcgaa ggcgtccttc agcggctccg gggtgtcctc gcgagcgaag gccaagccgc
    18961 cgtcgagctg gaacagggcg tcgtagaccg ccgggttccg ctcggcgaac tccaggtacg
    19021 cgtgggcgag ggcagcgacc tgggcgcggt gaccgtcagc ggcggaggtg gcggcccgca
    19081 gcgccgcggc catctcggtg gcgccttcca gggcgacggc gccgatgatc tcgcgcttgc
    19141 cgcggaagtg gctgtagagg acgggctggc tgtactcgat gcgctcggcg agccggcgcg
    19201 tggtgaccgc gtcccagccc tgctgctcgg cgagttcgcg agccgtcgcc acgatgagac
    19261 gctcgcggct cgcccgttcc cgctttttgc gttcctgtac cgacatgcct ccattctagc
    19321 accgctagac aagcgagcgg cagcagcact agcgttgcct catcatctag cgtcgctaga
    19381 ttttggaagg ggtcatcatg ctcgacgcac ttgggatcgt cacgaccgtg atcgtcggac
    19441 tgctggtggg ggtggagttc tccgtcgcct tcgtcatcaa ccggatcctc gacgcgcttc
    19501 ccgacgacag cgcgcagctc gggcggagcc atggaggccg gatgctgggg gcgttgatgc
    19561 cgttctggta catcggctcg ctcgttctga gcgcgatctg ggccgtggcc ggatgggggg
    19621 aggggggagc gggtctggtc gtcgccgcgg gtgggctgct gctcctcagc gtggtcatgt
    19681 cgctcctgct gctcgtaccg atcaacaacc ggggcaagag gtggaccccg gagaaccggc
    19741 ccgaggactg gaaggagcag atgaaccgct gggaccgcta ccactacgtc cgcgtggccg
    19801 tgctcatcgc cgccttcgcg tcgctggccg cggccctcgc ctgaggcggg cccggcgcag
    19861 ccgcgtcctc ctggccgccc ctaccggccg gtgctgagct tcccggcgat ccggcccgcc
    19921 ggggtcagga cgaggaggca gccccggccg tcggtggggt cgggggcgcg gcggatgagt
    19981 tcgcgggcct ccatgcggga ggcgtgccgg gacaggcggc tgcgtgacca gcccatcttg
    20041 gcggcctgtt cgcgcagcgt gctggtgccg tcctcgcgct cggacagggt gctgagcacc
    20101 tcgtagtccg gctcgggcag gccgagtgcg gccaggtcct gtgccacgcc gacctggacg
    20161 gcggtcacca tgcggaggta cgcccgccag gtgcggtcgg cgtgaactca cgcccgcccc
    20221 cggcccgacc tgcgatgacg tccggtggag cgcaccgtca cctgcctgcg gttcagagtc
    20281 cggcgtcgac gaggacccct gccccggcga gggcgaagac gcctccgatc actctgcacg
    20341 tgatgacact gctgggccac gatcggtagg cgtaggacat cgcctggaac cggtcggccg
    20401 cccctcggac gttggtggcc aggagcgccc cgcccacgag agcgacgcca ccccacatca
    20461 ggtcgaacac ctggctgttc acgactaccc gttctgccct ttctggattc ggcgggcctc
    20521 ggcaacgagt tccggaggga gctgcggccc tgcgcacgcg tagtcgatca gcaggttccg
    20581 gtaggtggtg ctggcgagcg agggggccag ggcgatcagg gccttcaagt cgtcggccga
    20641 gccgacgagg cgtgtccggt aggcggcgct tgccgcgagc agggtgactt cgccgggttc
    20701 gtgctccagg ccctggtcga cgaggctcgc ggcggcggcg aagtcgccct gctcggcacg
    20761 caggtccgcc aggtccaggt agagggacca gttggcaggg tccaggagca gggcgcgttc
    20821 gaaggccgca gcagactgat ccaggttgcc cgtcgcgcgc caggtggccg ctcgcgcgag
    20881 cgccgtccac atgaccggat cgacggcatc ggcacggtcg cacagagcga aggacagttc
    20941 gtaccggccg caggcccgag gcagccgggc catggcggcc agcgattccg gcaccgggtc
    21001 ccgttcggac accacgtcga gggcatggaa ccagggcgcg aaccgcttcc gcatcgcgtc
    21061 ggagtccagg tcgcggccgt agtccaacgt ccgcagacac gcctcggcca gcgccgcggc
    21121 actcaccgca ccgagaaacc gcgcatcgcc gaaccagggt gcggcacccc aggcgacgtc
    21181 gggccgcaca cccgtgaccg aaccgagggc catcaccgcg ttgtccatgt ccccttcgag
    21241 gaacaggaag tacgcctgcg ccggcacggc actcaaggag ccgctctctt cgaggctctc
    21301 cttcagaccg tccgagcggc ggtcctgcca caactccgcg agggccgcat agggctccgg
    21361 agccgccggc gcagaggcta tcgcccccac cagaagctcc acggcgccca ccgggcttcc
    21421 gccgcagtgc gccatcacac cggcgagacc gactcccgcc gccactgact gattcgacat
    21481 cgccagagaa tacccgcgcc tcagacgggt ttgaggaggg tgcggaggtt ggccatgtgg
    21541 gctttgacgg cggcgatctg ggtggggtcg ggggtgggcc ggccgcctgc ggtgtgggtg
    21601 gtgtggcagg ggtggcagag gccgtcgggg agggcttcgg gtgggccggg gcggccgcag
    21661 tcggtgcatt cggcgaggag gcggcgggtg ggggtggggg tgttggctgc ggtgctgggg
    21721 gtggctggca ggcggggtgg cagtttgtcg atgaggcggc ggcggatcag gccgacgggg
    21781 gagtcgactt gggcggggag tcctgcggtg agggtgctgg tgaggtagtc ggcggtgacg
    21841 cctcggtcga gccattttgc tgcgaggggt tcgagggtgg tgcagtcgtc ggcggagagt
    21901 cccaggcggt ggtcgtcacg gccgaggcgg gcgagggcga ggtaggcggc ggagggagcg
    21961 gcttcccggg tgggcggcgc ggactcggtg gccggggtct ggggtggcgt gcgttggtgc
    22021 ggtacggggg cgagggccgg gggttccgca ggcgctgcta ggtccggtga ggcgggtgct
    22081 tccggcgtgg cggtggggcc tgtggcccgg gtggcgtctt cggtggcgag gtaggcgttc
    22141 caccactcgt tgtcgcgggc ggtccgggac cagaaggtcc ggaacaccca ccggcattcg
    22201 tcgcccgcgc cgacggagca ccggacgcgc cgcaggtgcc cggcgacgga cagagcgttg
    22261 aggacggtgg agatggcctg ttgcccgtac aggggaagct gcttggcgag ttgcttcacg
    22321 ctcatctcgg caccgtcggg gagatggtcg acgaacccgg cgacgtaccg ctcacgagtc
    22381 ggcagcaagg cgaagtcttc gcgcgtacgc ggctgttggc cgggcgcaga gcgtttgccg
    22441 tagccgggtt tggccatcgg gtacgcgggc gagactgcgg ggacaggcag ggcggagcta
    22501 aagtgcgggg tagccaatgg atcgttcttt ctaagggtgt cgatcttgcg gttagacccc
    22561 ggcctggtgc tacaacaccg cgtcggggtc gcttagttct cgcaccgtaa gcggcggtca
    22621 cgctccgccg caagctgtca cgattagtca tactggctga ccgtgacggg gtggggaggg
    22681 acgggaggtt ttccccaacc caccttattt tccccccggt taaagaaggc gctcgc
//
