LOCUS       NZ_KZ679082            10399 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Streptomyces sp. CS149 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ679082
VERSION     NZ_KZ679082.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS149
  ORGANISM  Streptomyces sp. CS149
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7754255)
  AUTHORS   Malmierca,M.G., Perez-Victoria,I., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Cooperative Involvement of Glycosyltransferases in the Transfer of
            Amino Sugars during the Biosynthesis of the Macrolactam Sipanmycin
            by Streptomyces sp. Strain CS149
  JOURNAL   Appl Environ Microbiol 84 (18), e01462-18 (2018)
   PUBMED   30006405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7754255)
  AUTHORS   Olano,C., Malmierca,M.G., Mendez,C. and Salas,J.A.
  TITLE     Characterization of the biosynthesis gene cluster for the
            macrolactam sipanmycins: involvement of four glycosyltransferases in
            the transfer of two aminosugars
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7754255)
  AUTHORS   Olano,C., Malmierca,M.G., Mendez,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2018) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 556.87x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 11:43:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,915
            CDSs (total)                      :: 6,834
            Genes (coding)                    :: 6,691
            CDSs (with protein)               :: 6,691
            Genes (RNA)                       :: 81
            rRNAs                             :: 12, 7 (16S, 23S)
            complete rRNAs                    :: 12, 7 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 143
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 52 of 144
            Pseudo Genes (incomplete)         :: 108 of 144
            Pseudo Genes (internal stop)      :: 12 of 144
            Pseudo Genes (multiple problems)  :: 27 of 144
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:40:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1488853
            Orig. end                         :: 1499252
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ679082.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Professor JA Salas
            laboratory.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="9"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(266..1342)
                     /locus_tag="C6W96_RS06720"
                     /old_locus_tag="C6W96_06705"
     CDS             complement(266..1342)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512211.1"
                     /locus_tag="C6W96_RS06720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06705"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_107410907.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2e-17, bitscore:
                     62.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRVKGRVLVGPDEVRDELWAVDGRITYERPPGADDAVTVRGWAL
                     PGLVDAHCHVGLDRHGPVDAATAEKQALTDREAGTLLIRDAGSPSDTRWIDDREDLPKI
                     IRAGRHIARTRRYIRNYAHEIEPGDLVAYVAQEARRGDGWVKLVGDWIDRDAGDLTACW
                     PRGEVEAAIAEAHRLGARVTAHCFAEESLTDLVEAGIDCVEHATGLTEDTIPLFAERGV
                     AIVPTLVNIATFPDLAAGGEAKFPRWSAHMRQLYDRRYDTVRSAYDAGIPVYVGTDAGG
                     SLAHGLVAGEVAELVKAGIPPLEALSATAWGARRWLGRPGLEEGAPADLVVYDADPRAD
                     VRVLAAPRHIVLNGRVIG"
     gene            1503..2609
                     /locus_tag="C6W96_RS06725"
                     /old_locus_tag="C6W96_06710"
     CDS             1503..2609
                     /NRPS_PKS="Domain: Aminotran_5 (19-283). E-value: 9.7e-27.
                     Score: 85.7. Matches aSDomain:
                     nrpspksdomains_C6W96_RS06725_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123620.1"
                     /locus_tag="C6W96_RS06725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06710"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_107410908.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-20, bitscore:
                     71.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLPPLTAGHFAAIERRVARLLATEQDVVITQGEALLPLE
                     GCIRGGARPGSTALNVVTGPYGQTFGNWLRDCGAQVVDLVVPFHTAVTAGQVAEALAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFMLDAVASVGAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSARAWERIAANPAAPRRSYLSLLDWKERWIDGGRTALPHAP
                     AQLEMLGLEACVARIEDEGLETVMARHASAAAATRAGAVALGGGLEPYVHEARDAAPVA
                     TTLRAPAGTDAAALVAAALAADPALPLVAGGGVLSKEMIRVNHYGADATRGAVLSSLAA
                     LGAALTDAGRQVDIEAARRAVSETWPSR"
     aSDomain        1560..2351
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6W96_RS06725_Aminotran_5.1"
                     /evalue="9.70E-27"
                     /label="C6W96_RS06725_Aminotran_5.1"
                     /locus_tag="C6W96_RS06725"
                     /protein_end="283"
                     /protein_start="19"
                     /score="85.7"
                     /tool="antismash"
                     /translation="ERRVARLLATEQDVVITQGEALLPLEGCIRGGARPGSTALNVVTG
                     PYGQTFGNWLRDCGAQVVDLVVPFHTAVTAGQVAEALAEHPEIDFVSLVHAEAATGNTN
                     PVAEIGEVVRAHGALFMLDAVASVGAEPLLPDAWGVDLCVIGAQKAMGGPAGVSAVSVS
                     ARAWERIAANPAAPRRSYLSLLDWKERWIDGGRTALPHAPAQLEMLGLEACVARIEDEG
                     LETVMARHASAAAATRAGAVALGGGLEPYVHEARDAAPVATT"
     misc_feature    complement(2663..2679)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 23.92"
                     /tool="antismash"
     misc_feature    complement(2705..2719)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     misc_feature    2737..2754
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.75"
                     /tool="antismash"
     misc_feature    complement(2739..2754)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    2749..2764
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    complement(2895..2909)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.51"
                     /tool="antismash"
     gene            2920..3450
                     /gene="ectA"
                     /locus_tag="C6W96_RS06730"
                     /old_locus_tag="C6W96_06715"
     CDS             2920..3450
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123622.1"
                     /locus_tag="C6W96_RS06730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06715"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_107410909.1"
                     /transl_table=11
                     /translation="MTAAPADLARARSEFLSIDAPRVEDGAAIWRIARDSQVLDLNSSY
                     SYLLWCRDFAATSVVARDESGEPIAFVTGYIRPDRPQTLVVWQVAVDAAHRGKGLAATL
                     LDALTARVAADQGLSSVETTITPDNTASDRLFTSYAQRHDVALEQEVLFDGDLFPEGTH
                     LPEVLYRIGPFAT"
     gene            3649..4911
                     /gene="ectB"
                     /locus_tag="C6W96_RS06735"
                     /old_locus_tag="C6W96_06720"
     CDS             3649..4911
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-363). E-value: 2.3e-71.
                     Score: 232.5. Matches aSDomain:
                     nrpspksdomains_C6W96_RS06735_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156968.1"
                     /locus_tag="C6W96_RS06735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06720"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_107410910.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.9e-76, bitscore:
                     255.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITPPALSVFETLESEVRSYCRGWPAVFDRAQGARLTDEDGHSY
                     LDFFAGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMATTAKRAFLETFQNVILRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGRESVVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARP
                     EWLRALKELCERQDMLLIVDDIQMGCGRTGGFFSFEEAGIVPDIVTLSKSISGYGLPMS
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALQAYWADGQMEKQTLARGEQIEQTLL
                     AVCAEEPTASFRGRGLVWGMEFEDPARASAVCARAFELGLLLETSGPQSEVVKLLPPLT
                     ITPEELDEGLRTLARSVRETA"
     aSDomain        3733..4737
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6W96_RS06735_Aminotran_3.1"
                     /evalue="2.30E-71"
                     /label="C6W96_RS06735_Aminotran_3.1"
                     /locus_tag="C6W96_RS06735"
                     /protein_end="363"
                     /protein_start="28"
                     /score="232.5"
                     /tool="antismash"
                     /translation="FDRAQGARLTDEDGHSYLDFFAGAGSLNYGHNNPVLKRALIDYIE
                     RDGITHGLDMATTAKRAFLETFQNVILRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     RESVVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVPDFLWFER
                     LLEDQGSGLNKPAAVIVETVQGEGGINVARPEWLRALKELCERQDMLLIVDDIQMGCGR
                     TGGFFSFEEAGIVPDIVTLSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TAAAALQAYWADGQMEKQTLARGEQIEQTLLAVCAEEPTASFRGRGLVWGMEFE"
     gene            5001..5399
                     /locus_tag="C6W96_RS06740"
                     /old_locus_tag="C6W96_06725"
     CDS             5001..5399
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123624.1"
                     /locus_tag="C6W96_RS06740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06725"
                     /product="ectoine synthase"
                     /protein_id="WP_006123624.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.2e-53, bitscore:
                     178.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFSDIENTDRHVKAASGTWESKRIVLAKEKVGFSLHETVLY
                     AGTETSMWYANHIEAVLCTEGEAELTNDETGEKHWITPGTMYLLDGHERHTMRPKTDFR
                     CVCVFNPPVTGREDHDENGVYPLLTEEG"
     gene            5403..6296
                     /gene="thpD"
                     /locus_tag="C6W96_RS06745"
                     /old_locus_tag="C6W96_06730"
     CDS             5403..6296
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156966.1"
                     /locus_tag="C6W96_RS06745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06730"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_107410911.1"
                     /sec_met_domain="PhyH (E-value: 1.6e-38, bitscore: 131.7,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEVRADLYPSRGAAEMTTPRQDPVIWSAPGAPGPIAAKDLQSY
                     EHDGFLSIEQLITPDEVAVYRAELDRLVADPLIRADERSIVEKQTQNVRSVFEVHKISE
                     VFAGLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNM
                     RTVSVSIALTENFDTNGGLMIMPGSHKSFLGCAGETPKDNYKKSLQMQDAGTPSDEALT
                     KMADRHGIKLFTGKAGSATWFDCNAMHGSGDNITPYARSNVFIVFNSVENAAQEPFAAP
                     IRRPEFIGARDFTPVK"
     gene            6397..7431
                     /locus_tag="C6W96_RS06750"
                     /old_locus_tag="C6W96_06735"
     CDS             6397..7431
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070337.1"
                     /locus_tag="C6W96_RS06750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06735"
                     /product="VOC family protein"
                     /protein_id="WP_107410912.1"
                     /transl_table=11
                     /translation="MTSHVRHITIDCSDAYELGTFWAQVLGARISDEDLPGDPEALVET
                     PGAAILFVQVDEPKQTKNRVHLDIQPHDRSRDEEVERLLALGATLVGDHRRPNGRGWAT
                     LADPEGNEFCVECSAAERAALTGTRLPLTADDVTTAVRLAVDTLAKAPADRWEARAGSL
                     EWTCWETAEHLGDDLFAYAVQLGPRTPPLDRDVPFRWAPDREGGPHNAVFADREAGPAG
                     LLATLEASGALLASMVRTTPPGVRSYHGYGISDPEGFAAMGVVETLVHAHDLAEGLGLE
                     WAPPAALCDRALARLFPDAPAGGDRWAVLLWATGRAELPGHPRRTAWRWDGRPPADQTA
                     SSAG"
     gene            complement(7407..8477)
                     /locus_tag="C6W96_RS06755"
                     /old_locus_tag="C6W96_06740"
     CDS             complement(7407..8477)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969934.1"
                     /locus_tag="C6W96_RS06755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06740"
                     /product="alkene reductase"
                     /protein_id="WP_107410913.1"
                     /transl_table=11
                     /translation="MTTVFDPIDLSGTPLANRIALAPMTRSRAGEGGTATELTATYYAQ
                     RASAGLVITEGIQPSVVGQGYPSTPGLHSAEQVASWRTVTDAVHAQGGKIFAQIMHAGR
                     IGHPVLLPDGLVPVSASPVKAEGQVYTHVGPKDFVEPHELTDAEVRASVADFVTAARNA
                     VAAGFDGVELHGANGYLIHQFLAPNTNRRTDAWGGSDEARTRFAVEVVKAVAAEIGPER
                     TGLRISPGNPYNDIDEPAPEATYTALVRAIEPLGLAYLHILEAAPIRELTLALRKAFSG
                     TLVINVHSEGPTGPGDHTVIDDGIADLISYGALFLANPDLPARLKAGGPFNTPDPSTFF
                     GGDAKGYTDYPALDAV"
     misc_feature    complement(8462..8476)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     gene            8675..9190
                     /locus_tag="C6W96_RS06760"
                     /old_locus_tag="C6W96_06745"
     CDS             8675..9190
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123628.1"
                     /locus_tag="C6W96_RS06760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06745"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_093805680.1"
                     /transl_table=11
                     /translation="MTRATPAEDACTNALPTAALGGPVSHAVSRVARLHRIAAGKALKG
                     VDLYPGQELLMMHLWDRGAVRQTELIRALELDPSTVTKMLQRLEQTGHVRRRPDPADRR
                     AVLVEATDQSCALHTAVEAAWGSLEEHTLAGLDPAERTELVRLLAKVEENLCRETEDCP
                     DRRRAASA"
     gene            complement(9246..10304)
                     /locus_tag="C6W96_RS06765"
                     /old_locus_tag="C6W96_06750"
     CDS             complement(9246..10304)
                     /NRPS_PKS="Domain: Aminotran_5 (19-347). E-value: 5.2e-24.
                     Score: 76.8. Matches aSDomain:
                     nrpspksdomains_C6W96_RS06765_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070339.1"
                     /locus_tag="C6W96_RS06765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_06750"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_107410914.1"
                     /sec_met_domain="Aminotran_5 (E-value: 4.8e-17, bitscore:
                     60.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILAPIQAAAVEFAPEVTYLNTSSWGLLPRRTIAAVKALADENA
                     AGRRVGAGSFEAVEAARVGFARLVGVHPDRVATGSSVTVHVGLIAASLPPGAEVLCPEG
                     EFSSVVSPFALRGDLRMRYAPLADLAGAVRESTALVAFSAVQSADGRVADLDAVRAAAA
                     AHGARTLLDATQAAGWFPVDAGAYDYTVTGGFKFLLCPRGTSFLTVTEEAQDTLPALFA
                     GWVSAGAPWTSNYGPLERLAPTARGFDEPPAFLSYHGAEHSLALLAEVGSDALYAHATG
                     LAARLRAGLANLGHKPVPGESAIVAVPGLDGLQPELVEAGIAVSAPAGNLRISCHLYNT
                     EADVDRLLDFLA"
     aSDomain        complement(9264..10247)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6W96_RS06765_Aminotran_5.1"
                     /evalue="5.20E-24"
                     /label="C6W96_RS06765_Aminotran_5.1"
                     /locus_tag="C6W96_RS06765"
                     /protein_end="347"
                     /protein_start="19"
                     /score="76.8"
                     /tool="antismash"
                     /translation="YLNTSSWGLLPRRTIAAVKALADENAAGRRVGAGSFEAVEAARVG
                     FARLVGVHPDRVATGSSVTVHVGLIAASLPPGAEVLCPEGEFSSVVSPFALRGDLRMRY
                     APLADLAGAVRESTALVAFSAVQSADGRVADLDAVRAAAAAHGARTLLDATQAAGWFPV
                     DAGAYDYTVTGGFKFLLCPRGTSFLTVTEEAQDTLPALFAGWVSAGAPWTSNYGPLERL
                     APTARGFDEPPAFLSYHGAEHSLALLAEVGSDALYAHATGLAARLRAGLANLGHKPVPG
                     ESAIVAVPGLDGLQPELVEAGIAVSAPAGNLRISCHLYNTEADVDRL"
ORIGIN
        1 cacagtccaa tgggggacat cgcccgcgcc ggtggcctcg actccgtgaa tctttacgca
       61 ctgagggtga accggcggat acctgacgtg agttcacccc aaaggggggt ttccgcgcgc
      121 atattcgaat ctttcggcac gtgcgttccc tccggcctct ccccgtcacc cgtttcacac
      181 ggcagggacg aggtacggga acgggccggg ctgtaccaac gagccgacag ccgcatccgt
      241 cactgcccgt caacacaccg ccccgtcagc cgatgaccct cccgttcagc acgatgtgcc
      301 ggggtgccgc cagcacccgg acgtccgcgc gcgggtccgc gtcgtacacg accaggtccg
      361 ccggggcccc ctcctccagg ccgggccgcc ccagccagcg cctggccccc cacgcggtcg
      421 cggagagggc ctccaggggc gggatgcccg ccttgaccag ctcggcgacc tcgcccgcga
      481 ccaggccgtg cgccagggag ccgcccgcgt cggtgccgac gtagaccggg atcccggcgt
      541 cgtaggcgga gcgcacggtg tcgtagcggc ggtcgtacag ctgccgcata tgggccgacc
      601 agcgggggaa cttggcctcg ccgcccgccg cgaggtcggg gaaggtggcg atgttgacca
      661 gcgtcgggac gatcgcgacg ccgcgttcgg cgaagagcgg gatggtgtcc tcggtgaggc
      721 cggtggcgtg ctcgacgcag tcgatgcccg cctccaccag atcggtgagc gactcctcgg
      781 cgaagcagtg agcggtgacc cgggcgccca gccggtgcgc ctcggcgatg gccgcctcga
      841 cctcgccgcg cggccagcag gcggtgaggt ccccggcgtc gcggtcgatc cagtccccca
      901 cgagcttgac ccagccgtcg ccgcgccggg cctcctgggc gacgtacgcg acgaggtcgc
      961 cgggctcgat ctcgtgcgcg tagttacgga tgtagcggcg ggtcctggcg atgtggcggc
     1021 cggccctgat gatcttcggc aggtcctcgc ggtcgtcgat ccagcgggtg tcggagggcg
     1081 atccggcgtc ccggatcagc agggtccccg cctcccggtc ggtgagcgcc tgcttctccg
     1141 cggtcgccgc gtcgaccggt ccgtgccggt ccaggccgac atggcagtgg gcgtcgacga
     1201 ggccgggcag cgcccagccc ctgaccgtca ccgcgtcgtc ggcgccgggc gggcgctcgt
     1261 aggtgatccg cccgtccacc gcccacagtt cgtcccggac ctcgtccggg ccgaccagca
     1321 cccggccctt cacccgcagc accggccgct cctcccgatc acgcacttcg accacccgtc
     1381 cggccaatcg tccgaccgct cacccgatca ctcatacgcg gcactgtacg aggcctccgg
     1441 tgggccgtcg gtaggctgcc agtgcctttc gaccgacgga cgaacccgaa gagagcccca
     1501 ccgtgacgca ccccttcctc gaccttcccc cgctgaccgc cggccacttc gcggcgatcg
     1561 agcggcgtgt ggcccggctc ctcgccacgg agcaggacgt cgtcatcacc cagggcgagg
     1621 cgctgctgcc cctggagggc tgtatccgcg gcggggcgcg gcccggctcg accgcgctga
     1681 acgtggtcac gggtccgtac gggcagacct tcggcaactg gctgcgggac tgcggcgccc
     1741 aggtcgtcga tctcgtggtg cccttccaca cggcggtgac cgccggccag gtcgccgagg
     1801 cgctggccga gcacccggag atcgacttcg tctcgctggt gcacgcggag gcggcgaccg
     1861 gcaacaccaa cccggtcgcg gagatcggcg aggtggtccg ggcgcacggc gcgctgttca
     1921 tgctggacgc ggtcgcctcg gtgggcgccg aaccgctgct gccggacgcc tggggcgtcg
     1981 acctgtgcgt gatcggcgcg cagaaggcca tgggcgggcc cgccggggtc tccgcggtgt
     2041 cggtgagcgc gcgggcctgg gagcggatcg ccgccaaccc ggccgccccg cgccgctcct
     2101 acctctcgct gctggactgg aaggagcgct ggatcgacgg cggccgcacg gctctgccgc
     2161 acgccccggc gcagctggag atgctcggcc tggaggcgtg tgtggcccgg atcgaggacg
     2221 agggcctgga gacggtgatg gcccggcacg cctcggccgc cgcggcgacc cgggccggag
     2281 cggtggcgct gggcggcggt ctcgagccgt acgtacacga ggcgcgggac gcggccccgg
     2341 tggcgacgac gctgcgcgcc ccggcgggga cggacgcggc cgcgctggtc gcggcggcac
     2401 tggcggccga ccccgcgctg ccgctggtcg cgggcggcgg ggtgctgtcc aaggagatga
     2461 tccgggtcaa ccattacggg gcggatgcga cgcggggcgc cgtgctgtcc tcgctcgcgg
     2521 ctctgggggc ggcgctgacc gatgcgggcc ggcaggtcga tatcgaggct gcccgccggg
     2581 ccgtttcgga aacctggccg agccgctgaa ttgttcacga tgcggggagc tgctttatcg
     2641 aaagcagctc cccgcattct tttgcccgct tttccgtcac ctaaacgcgg aagtttttgc
     2701 gcggatcgaa gctcatgatt cggacacgtt cccagagagt tacgaccctg tgaccgactc
     2761 cacatgggcg gcgttatgcc cgttaaattc aggacaaagc ggtggaaatt ctacccggat
     2821 catggggcgg ttcgcgcacg cctgataaca catgaacgtt cttcacccaa cccctcacgt
     2881 cgatgcaatt tcggaatttg ctgggtaaat tcaattcgca tgaccgccgc accagcagat
     2941 cttgcccgtg cccgaagcga attcctcagt atcgatgcgc cgcgagtgga ggacggagcc
     3001 gcgatctggc gcattgcccg cgactcccag gtcctggacc tgaactcctc gtacagctac
     3061 ctgctgtggt gccgtgactt cgccgcgacc tccgtcgtcg cccgtgacga gagcggcgag
     3121 cccatcgcct tcgtgacggg ctacatccgg cccgaccgcc cccagaccct cgtcgtctgg
     3181 caggtggccg tcgacgcggc ccaccgcggc aaggggctgg ccgccacgct gctggacgcg
     3241 ctgaccgccc gggtcgccgc cgaccagggc ctgtcgtccg tggagacgac gatcaccccg
     3301 gacaacaccg cctccgaccg gctgttcacg tcctacgccc agcggcacga cgtggcgctg
     3361 gagcaggagg tcctcttcga cggcgatctg ttccccgaag ggacccacct gcccgaggtg
     3421 ctctaccgga tcggcccgtt cgccacctga gcccgcccgg gcacgccctc ggcgtccccg
     3481 gcccgtacgc ccgccgcccg caactcgccg cccggcgcac ccgacccgtg cgcccggtcc
     3541 ccacgacttt tcgcgccggc cgaccacccg gcgcggtccc ggccgcatcc gtgcggcggg
     3601 gagcacgaga ccaccgcccg tcacaccccc tcacgcagga gacccgctgt gaccatcacc
     3661 ccgcccgcac tgagtgtctt cgagaccctg gagtccgagg tccggagcta ctgccgcggc
     3721 tggcccgccg tcttcgaccg tgcgcagggc gcccggctga ccgacgagga cggccactcc
     3781 tacctggact tcttcgccgg ggccggctcg ctcaactacg gccacaacaa cccggtcctg
     3841 aaacgagcgc tgatcgacta catcgagcgc gacggcatca cccacggcct ggacatggca
     3901 accaccgcca agcgcgcgtt cctggagacg ttccagaacg tgatcctgcg cccgcgcgac
     3961 ctgccgtaca aggtgatgtt ccccggcccg accggcacca acgccgtcga gtcggcgctg
     4021 aagctggccc gtaaggtcaa gggccgcgag tccgtcgtct cgttcaccaa cgccttccac
     4081 ggcatgtcgc tgggctcgct cgccgtcacc ggcaacgcct tcaagcgcgc cggggccggg
     4141 atcccgctgg tgcacggcac cccgatgccg ttcgacaact acttcgacgg tacggtcccc
     4201 gacttcctgt ggttcgagcg gctgctggag gaccagggct ccgggctgaa caagcccgcc
     4261 gccgtgatcg tggagacggt ccagggcgag ggcggcatca acgtcgcccg gcccgagtgg
     4321 ctgcgcgcgc tcaaggagct gtgcgagcgc caggacatgc tgctgatcgt cgacgacatc
     4381 cagatgggct gcggccggac cggcggcttc ttctccttcg aggaggccgg catcgtcccg
     4441 gacatcgtca cgctgtcgaa gtccatcagc ggctacgggc tgccgatgtc gctctgcctg
     4501 ttcaagccgg agctggacat ctgggagccg ggcgagcaca acggcacctt ccgcggcaac
     4561 aacccggcct tcgtcacggc cgccgccgcg cttcaggcgt actgggcgga cggccagatg
     4621 gagaagcaga ccctggcccg cggcgagcag atcgagcaga cgctgctggc cgtctgcgcc
     4681 gaggagccga ccgcgagctt ccgtggccgg ggcctggtgt ggggcatgga gttcgaggac
     4741 ccggcccgcg cctccgcggt ctgcgcccgc gccttcgaac tggggctcct gctggagacc
     4801 tccggcccgc agagcgaggt cgtcaagctg ctgccgccgc tgaccatcac ccccgaggag
     4861 ctggacgagg gcctgcgcac gctggcccgc tccgtccgcg agacggcctg acccggaacc
     4921 gccggggcag gtggaagaag agaggccccg ggccgtgacg cccggggccc gtgcagagaa
     4981 gagaaaggca accgctcacc gtgatcgtcc gatcgttcag tgacatcgag aacaccgacc
     5041 ggcatgtgaa ggccgcgtcc ggcacctggg agagcaagcg catcgtgctc gccaaggaga
     5101 aggtgggctt ctcgctccac gagaccgtgc tgtacgcggg cacggagacc tccatgtggt
     5161 acgcgaacca catcgaggcg gtgctgtgca ccgagggcga ggccgagctc accaacgacg
     5221 agaccggcga gaagcactgg atcacgcccg gcacgatgta tctgctggac gggcatgagc
     5281 ggcacaccat gcggcccaag accgacttcc gctgcgtgtg cgtcttcaat ccccccgtca
     5341 ccggacggga ggaccatgac gagaacggtg tctacccact gctgaccgag gagggctgaa
     5401 ccatgaccac cgaagtacgc gccgatctgt acccctcgcg cggcgccgcc gagatgacca
     5461 ctccccgcca ggacccggtc atctggtccg cgccgggcgc accgggtccg atcgccgcca
     5521 aggacctgca gagctacgag cacgacggct tcctcagcat cgagcagctg atcacgccgg
     5581 acgaggtcgc cgtctaccgg gcggagctgg accggctggt cgccgacccg ctgatccggg
     5641 ccgacgagcg ctccatcgtg gagaagcaga cgcagaacgt gcggtccgtc ttcgaggtcc
     5701 acaagatcag tgaggtcttc gccgggctgg tccgcgacga gcgggtggtg ggccgggccc
     5761 gccagatcct cggctcggac gtgtacgtcc accagtcccg gatcaatgtg aagccgggct
     5821 tcggggcctc gggcttctac tggcactcgg acttcgagac gtggcacgcg gaggacggtc
     5881 tgccgaacat gcggacggtc tccgtgtcga tcgcgctgac ggagaacttc gacaccaacg
     5941 gcgggctgat gatcatgccc ggttcgcaca agtcgttcct cggctgtgcg ggcgagacgc
     6001 cgaaggacaa ctacaagaag tcgctccaga tgcaggacgc cggcaccccg tccgacgagg
     6061 cgctgacgaa gatggccgac cgccacggca tcaagctctt cacgggcaag gccggttcgg
     6121 cgacctggtt cgactgcaac gccatgcacg gttcgggcga caacatcacc ccgtacgcgc
     6181 gcagcaacgt cttcatcgtc ttcaacagcg tggagaacgc ggcgcaggag cccttcgcgg
     6241 ctccgatccg ccgcccggag ttcatcgggg cgcgggactt caccccggtg aagtagcgcg
     6301 acgcgcaggc gggaggggcc gggacggtac gccgtcccgg cccttcgcgc gtaactcgct
     6361 ggaccggggc ccgagtcggc ggagaggctg tccgccatga cttcccatgt acgccacatc
     6421 acgatcgact gttccgacgc ctacgaactc ggcaccttct gggcccaggt gctcggcgcc
     6481 cggatctccg acgaggacct tcccggtgat ccggaggcgc tggtggagac gcccggcgcg
     6541 gcgatcctct tcgtacaggt ggatgagccc aaacagacca agaaccgcgt ccatctcgac
     6601 atccagccgc acgaccgctc ccgcgacgag gaggtcgagc ggctgctcgc gctcggcgcg
     6661 accctcgtcg gcgaccaccg caggccgaac gggcggggct gggcgacgct cgccgacccc
     6721 gagggcaacg aattctgtgt ggagtgcagc gcggccgagc gggcggcgct gaccggaacc
     6781 cggctgcccc tgaccgccga cgacgtgacg accgccgtgc gcctcgcggt ggacacgctg
     6841 gcgaaggcgc cggcggaccg ctgggaagcc agggccggtt cgctggagtg gacctgctgg
     6901 gagacggcgg agcacctggg cgacgatctg ttcgcgtacg cggtgcagtt gggaccccgg
     6961 acgcctccgc tggaccgcga cgtgcccttc cggtgggcgc cggaccggga gggcggtccg
     7021 cacaacgcgg tcttcgccga ccgggaggcc gggcccgccg ggctgctcgc cacgctggag
     7081 gcgagcgggg cgctgctggc ctcgatggtg cggacgacgc cgcccggggt gcgctcgtac
     7141 cacgggtacg ggatctccga cccggaaggc ttcgccgcga tgggtgtggt ggagaccctg
     7201 gtgcacgccc atgacctggc ggagggtctt ggcctggagt gggcgccgcc cgccgcgctc
     7261 tgcgaccggg cgctggcccg gctcttcccg gacgcgccgg cgggcggcga ccggtgggcc
     7321 gtcctgctgt gggccaccgg ccgcgccgaa ctgccgggcc acccgcgccg caccgcgtgg
     7381 cggtgggacg ggcggccgcc ggcggatcag acggcgtcga gcgccgggta gtcggtgtag
     7441 cccttggcgt cgccgccgaa gaaggtcgac gggtcggggg tgttgaacgg gccgcccgcc
     7501 ttcagccggg cgggcaggtc cgggttggcg aggaagagcg ccccgtagga gatcaggtcg
     7561 gcgatgccgt cgtcgatcac cgtgtggtcg ccggggccgg tggggccctc ggagtgcacg
     7621 ttgatgacga gggtgccgga gaaggccttg cgcagggcga gggtcagctc gcggatcggg
     7681 gcggcctcca ggatgtgcag ataggcgagg ccgagcggct cgatcgcgcg gaccagcgcg
     7741 gtgtacgtgg cctccggcgc gggctcgtcg atgtcgttgt acgggttgcc gggcgagatg
     7801 cgcagtccgg tgcgctcggg gccgatctcg gcggcgacgg ccttgacgac ctcgacggcg
     7861 aagcgggtgc gggcctcgtc ggagccgccc cacgcgtcgg tgcgccggtt ggtgttgggg
     7921 gcgaggaact ggtggatgag gtagccgttg gcgccgtgca gctcgacccc gtcgaacccg
     7981 gccgccaccg cgttgcgggc ggcggtgacg aagtcggcga cgctcgcgcg gacctcggcg
     8041 tcggtcagct cgtgcggctc gacgaagtcc ttcggtccga cgtgggtgta gacctgtccc
     8101 tcggccttga ccggggatgc gctgacgggg acgagcccgt ccggcagcag gaccgggtgg
     8161 ccgatgcggc ccgcgtgcat gatctgggcg aagatcttgc cgccctgcgc atgcaccgcg
     8221 tcggtgaccg tacgccagga ggcgacctgc tcggcgctgt gcagcccggg cgtggagggg
     8281 tagccctggc ccacgacgga cggctggatg ccctcggtga tgacgagtcc cgccgaggcg
     8341 cgctgggcgt agtacgtggc ggtcagctcg gtggcggtgc cgccctcccc ggcccggctg
     8401 cgggtcatcg gggccagcgc gatgcggttg gccagggggg tgccggacag gtcgatcggg
     8461 tcgaaaacgg tggtcatgag ggctcccgga taagtatgtg gtcggccaag agaaagtatg
     8521 tggtcggcca acgatcgccg ccgggtgtaa ctgtaaccca ttcgttggcc gaccaaggta
     8581 aagttgtcgg aaaccgtcgg gcatcatcgg aagccgccac cgaggccacg accgaagccg
     8641 ccgctcaccg ccccgaggac cccaggagcc cgccatgacc cgcgccaccc ccgcggaaga
     8701 cgcctgtacg aacgcgctgc ccacggcggc gctcggcggg cccgtcagcc acgccgtctc
     8761 ccgggtggcg cggctgcacc ggatcgcggc gggcaaggcg ctcaaggggg tggacctcta
     8821 cccggggcag gagctgctga tgatgcacct gtgggaccgg ggggcggtcc ggcagacgga
     8881 gctgatccgg gctctggagc tggacccatc cacggtcacc aagatgctcc agcggctgga
     8941 gcagaccggg catgtgcgcc gccgccccga cccggccgac cggcgggccg tgctggtcga
     9001 ggcgacggat cagagctgcg cgctgcacac cgcggtggag gcggcctggg gcagcctgga
     9061 ggagcacacg ctcgcgggtc tggacccggc cgagcgcacg gagctggtgc ggctgctggc
     9121 gaaggtcgag gagaacctct gccgggagac cgaggactgc cccgaccggc gccgggccgc
     9181 gtccgcctga gccgcacccg tacggcccga gccacgtccg tacggcccga gccacgtccg
     9241 tacgctcagg ccaggaagtc cagcagccgg tccacatcgg cctcggtgtt gtagaggtgg
     9301 caggagatcc gcagattccc ggccggggcg gagacggcga tcccggcctc caccagctcg
     9361 ggctggagcc cgtcgagccc cggtacggcg acgatcgccg actccccggg aacgggcttg
     9421 tgcccgaggt tcgcgaggcc cgcccgcagc cgggcggcga gcccggtggc gtgcgcgtac
     9481 agggcgtcgg agccgacctc cgcgagcagg gcgagggagt gctcggcccc gtggtacgag
     9541 aggaaggcgg gcggctcgtc gaagccccgg gcggtcgggg cgaggcgctc cagcgggccg
     9601 tagttgctcg tccagggggc gcccgcggag acccagcccg cgaagagggc cggcagggtg
     9661 tcctgcgctt cctcggtgac ggtcaggaac gacgtaccgc gcgggcagag caggaacttg
     9721 aagccgccgg tgaccgtgta gtcgtacgcc ccggcgtcca ccgggaacca gcccgccgcc
     9781 tgggtggcgt ccagcagggt gcgggccccg tgcgccgcgg cggcggcgcg gacggcgtcg
     9841 aggtcggcga cccggccgtc ggccgactgc acggcggaga aggcgaccag cgcggtcgac
     9901 tcccggacgg ctccggcgag atccgcgagc ggcgcgtacc gcatgcgcag atcgccgcgg
     9961 agcgcgaacg ggctcaccac ggaggagaac tcgccctcgg ggcagaggac ttcggcgccg
    10021 ggcggcagcg aggcggcgat gaggccgaca tggacggtga cggagctgcc ggtggcgacc
    10081 cggtccgggt ggaccccgac gagccgggcg aagccgaccc gggcggcctc cacggcctcg
    10141 aagctgccgg cccccacccg gcggcccgcg gcgttctcgt cggccagggc cttgacggcg
    10201 gcgatcgtcc ggcggggcag caggccccag ctggaggtgt tgaggtaggt gacctcgggc
    10261 gcgaattcga cggctgcggc ttggatgggc gcgaggatcg tcatgcgtcc accctggagc
    10321 cccctcaacc caaagtcaat tacagagagt taaggggaac tccaaagaaa tgcttatgga
    10381 agctcgcagg ccccgtccg
//
