LOCUS       NZ_KZ679082            28391 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Streptomyces sp. CS149 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ679082
VERSION     NZ_KZ679082.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS149
  ORGANISM  Streptomyces sp. CS149
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7754255)
  AUTHORS   Malmierca,M.G., Perez-Victoria,I., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Cooperative Involvement of Glycosyltransferases in the Transfer of
            Amino Sugars during the Biosynthesis of the Macrolactam Sipanmycin
            by Streptomyces sp. Strain CS149
  JOURNAL   Appl Environ Microbiol 84 (18), e01462-18 (2018)
   PUBMED   30006405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7754255)
  AUTHORS   Olano,C., Malmierca,M.G., Mendez,C. and Salas,J.A.
  TITLE     Characterization of the biosynthesis gene cluster for the
            macrolactam sipanmycins: involvement of four glycosyltransferases in
            the transfer of two aminosugars
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7754255)
  AUTHORS   Olano,C., Malmierca,M.G., Mendez,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2018) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 556.87x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 11:43:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,915
            CDSs (total)                      :: 6,834
            Genes (coding)                    :: 6,691
            CDSs (with protein)               :: 6,691
            Genes (RNA)                       :: 81
            rRNAs                             :: 12, 7 (16S, 23S)
            complete rRNAs                    :: 12, 7 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 143
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 52 of 144
            Pseudo Genes (incomplete)         :: 108 of 144
            Pseudo Genes (internal stop)      :: 12 of 144
            Pseudo Genes (multiple problems)  :: 27 of 144
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:40:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 299915
            Orig. end                         :: 328306
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ679082.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Professor JA Salas
            laboratory.
FEATURES             Location/Qualifiers
     region          1..28391
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="5"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..28391
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..28391
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:18391]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18391
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(293..919)
                     /locus_tag="C6W96_RS01375"
                     /old_locus_tag="C6W96_01370"
     CDS             complement(293..919)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955598.1"
                     /locus_tag="C6W96_RS01375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01370"
                     /product="hypothetical protein"
                     /protein_id="WP_107409891.1"
                     /transl_table=11
                     /translation="MRISSSVRPRSARTGAKVAVAVAVAGASLAGAPAAYAAPGDSGNI
                     DVRSVSWHSSRDGVEVCKFVLSASNFESFPSVPWTITEQPPTVPPGTTLMDRLPLINGS
                     ARSEAYLLPEGTYQLVWVVPAGPKQRSFKVECDRGNHGSKPHKPQQPIGGVPAGGGGVP
                     DMEPVSSESGSNAATTGAVLAAGAAGAAGLIMMRRSARRRARGEA"
     misc_feature    complement(981..994)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.2"
                     /tool="antismash"
     misc_feature    982..995
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.88"
                     /tool="antismash"
     misc_feature    991..1004
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.27"
                     /tool="antismash"
     gene            complement(1738..2436)
                     /locus_tag="C6W96_RS01385"
                     /old_locus_tag="C6W96_01380"
     CDS             complement(1738..2436)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971720.1"
                     /locus_tag="C6W96_RS01385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01380"
                     /product="GAF and ANTAR domain-containing protein"
                     /protein_id="WP_107414741.1"
                     /transl_table=11
                     /translation="MDWQIFARRMAAMAHDLLEQDSVAGTLDRIAASATELVEGCDAAG
                     ILILRGERVQTLAATGPMAEESHRLQERLKEGPCFDATRRRDGERVFRIADMTELQQRW
                     PAFAPQAAELGIGSMMGFLLFADEENLGALNLYSRLPGRFTETSETAGWVLASHAAVAL
                     SSARNHAQLTEAVATRHVIGEAMGILMARHRVPENEAFNVLRRHSQDHNVKLREVARQV
                     TELGALPRLG"
     misc_feature    2602..2618
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.32"
                     /tool="antismash"
     gene            complement(2703..3293)
                     /locus_tag="C6W96_RS01390"
                     /old_locus_tag="C6W96_01385"
     CDS             complement(2703..3293)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009085885.1"
                     /locus_tag="C6W96_RS01390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01385"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_107409895.1"
                     /transl_table=11
                     /translation="MSTVPRGSRLRADARRNSEQIRAAAISAFQGQGLTVPLEEVAKAA
                     GVSKATIFNRFGGRIGLIEAVIEELVARELFALIGHARAIDDVGERIVYYVTALRDLQY
                     RQPAFNDVLLRTYPRSQQLMEICRRGSEANEEFVAAAQARDVLRPEFTSSDLHALVVDN
                     ALALKHGELPPRHDYDRRTTYLLDGIRTPPQTG"
     gene            3408..4295
                     /locus_tag="C6W96_RS01395"
                     /old_locus_tag="C6W96_01390"
     CDS             3408..4295
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044434.1"
                     /locus_tag="C6W96_RS01395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01390"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_107409897.1"
                     /transl_table=11
                     /translation="MIVVTGATGGLGGTTVEHLLKRVPADRIGVSVRDTAKAQHFADRG
                     VRVRQGTYEDPASLRHAFAGAEQILLVSGNDPGADMVSLHRNAIDAAVAAGTRRILYTS
                     QQGAVPGNPYRPSDIHMATEALLADSGVAWTALRNGAYGPLDQVLGPWQHTGVITQPQD
                     GPVPYTDRADIAEATAVMLAAHHSLDGPVDLTSPDAITFDDVARIASRLAGHPVERIVV
                     DDERWIADQTAAGVPEQMARLMLTWYQAARTGYFSQTSALLAELLGRKPLTVTDRLGRD
                     LDRRGPRRSEQPQA"
     misc_feature    complement(4313..4328)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.18"
                     /tool="antismash"
     misc_feature    complement(4641..4657)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.62"
                     /tool="antismash"
     misc_feature    4642..4656
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.09"
                     /tool="antismash"
     gene            4797..5537
                     /locus_tag="C6W96_RS01400"
                     /old_locus_tag="C6W96_01395"
     CDS             4797..5537
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C6W96_RS01400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C6W96_01395"
                     /product="sensor domain-containing protein"
                     /protein_id="WP_107409898.1"
                     /transl_table=11
                     /translation="MTALSALALAVLLSACGGGSADRAAPDTPPVSTPGTSGAPKSTSA
                     SPRPEQSTPTTDRPPSSGGSTSINLDAVALKDGDLAEFRLVDVPSTRSDSPGTVAPAAC
                     RVIADARRESYTPTPSTLVRRYAVATAGEHLGIGTQITLAGTTESAARDLLDALRAAVT
                     ACRDGYTGDGRGTTTVTAVTPVAVGDEGVAFRTAGRGIPTEYTFVRQGSVLLRFAASSA
                     RGKPVGVPSPVVVQQVMKVRAATD"
     misc_feature    4806..4808
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5582..6334
                     /locus_tag="C6W96_RS01405"
                     /old_locus_tag="C6W96_01400"
     CDS             5582..6334
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C6W96_RS01405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C6W96_01400"
                     /product="hypothetical protein"
                     /protein_id="WP_107409900.1"
                     /transl_table=11
                     /translation="MWGCLLVLLTVGLVGKLLVVPLTTSDLMAAQTPAQQPTWWQWAVL
                     VAISVATAVAVTWSAGRRRPGRAGTVALGTVVLLTLCTAVTLWVRARVGIEDWTSAATL
                     ESLVAGVVALSFRAGFRRWERGRPLAGEVWLAMVPYRERDEAARHYCVVRRRRLRGADV
                     LQITSQNKDGQDGYLPMPNGLWDVTSGKAHWVETTTPPRRVPYRDFLKDRPQGPCPPAT
                     WRLLRRPRPAPASPRLRRRSGRGTKTAP"
     gene            6803..>6937
                     /locus_tag="C6W96_RS35685"
                     /pseudo=""
     CDS             6803..>6937
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955605.1"
                     /locus_tag="C6W96_RS35685"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="CBS domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MILPVGNDDVLRATENETVLDAAKKMKDLGVGALPICGADNRLKG
                     "
     gene            complement(7051..7272)
                     /locus_tag="C6W96_RS01420"
                     /old_locus_tag="C6W96_01415"
     CDS             complement(7051..7272)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049864.1"
                     /locus_tag="C6W96_RS01420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01415"
                     /product="DUF6480 family protein"
                     /protein_id="WP_107414742.1"
                     /transl_table=11
                     /translation="MSTGIPDPDPRETPGLEPGGGVSPGDTPPGESSTSEAGPRQETSK
                     GWAMGPLIAILTVAALVAGFFLAYALLL"
     gene            7309..7461
                     /locus_tag="C6W96_RS34715"
     CDS             7309..7461
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C6W96_RS34715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_159103525.1"
                     /transl_table=11
                     /translation="MAPGGPRPNRDQSFQELKHLLAGAAPGTGEGGAYLRQPARKTAAK
                     KRSAS"
     misc_feature    7338..7352
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.77"
                     /tool="antismash"
     gene            7505..8471
                     /locus_tag="C6W96_RS01425"
                     /old_locus_tag="C6W96_01420"
                     /pseudo=""
     CDS             7505..8471
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046230.1"
                     /locus_tag="C6W96_RS01425"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01420"
                     /product="ATP-dependent DNA ligase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLATPGPLPSAGVENRWAFEVKQDGQRAMIYLPGDGTILLRARSG
                     TDITAAYPELIPSPTPSAHKAPCWTRRSSRSTIRAATTSNASSSAWASPVLPRRPRGW"
     gene            complement(9298..9525)
                     /locus_tag="C6W96_RS01430"
                     /old_locus_tag="C6W96_01425"
                     /pseudo=""
     CDS             complement(9298..9525)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153088.1"
                     /locus_tag="C6W96_RS01430"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01425"
                     /product="DUF2945 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAKGKKLKKGDSVSWSSHGQTVPGKVKKKITERGEVAGRTVNASE
                     AEPQ"
     misc_feature    9512..9524
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            10001..11266
                     /locus_tag="C6W96_RS01435"
                     /old_locus_tag="C6W96_01430"
     CDS             10001..11266
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971152.1"
                     /locus_tag="C6W96_RS01435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01430"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_107409904.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.9e-50, bitscore:
                     169.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRSQPTEHSLGEPSQPAGKSKEHRQPGLSSEDAQVVDADVVHAV
                     LRTARAVLSERVGEAGEHDVLFSEELARRVADFTLDGGKRMRPRLLWWGMRACGAAETA
                     AALRLGVALELIQTCALIHDDVMDRSRLRRGQPAVHVGLAEHAGLSPHSERGSAFGSSA
                     AVLAGDLALVWADDTVAETVLSAAQRRRIGTLWRAMRTEMIAGQYLDLHGQVSGGSSVV
                     QALRTASLKSASYSVERPLMLGAALAGADEWTTEALSAAGRCAGLAFQLRDDLLGVFGD
                     PGVTGKPSGDDIREGKPTYLLAVARTWAEAAGDEEALAVLSRVTGNDDLTEDDFADVLG
                     VFEVTGARAHVEREAERLHDHAVHRLGQAVDVEAHGGRQLLGLLRTVSGDWSGHSALHT
                     GETDGAAAAARLLTAAEGGSPR"
     gene            11263..12780
                     /locus_tag="C6W96_RS01440"
                     /old_locus_tag="C6W96_01435"
     CDS             11263..12780
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456520.1"
                     /locus_tag="C6W96_RS01440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01435"
                     /product="phytoene desaturase"
                     /protein_id="WP_107409906.1"
                     /sec_met_domain="DAO (E-value: 1.7e-16, bitscore: 59.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITVKGPVDHVVVVGAGLAGLAAALHLLGAGRSVTVVEREEVPGG
                     RAGLLETGGFRIDTGPTVLTMPDLVEEAFAAVGEAMADRLELIRLDPAYRARFADGSQL
                     DVHTDGAAMEAAVEQFAGARQAVGYRRLRIWLERLYWVQMRRFIDANFDSPFQLVHPDL
                     ARLAALGGFGRLDARIGHFVSDERLRRVFSFQALYAGVPPARALAAYAVIAYMDTVAGV
                     YFPRGGMHALPRAMADAAADSGASFRYGQSVTRLERSGDRVTAVVTDQERIACDAVVLT
                     PDLPVSYRLLGRSPRRPLPLRHSPSAVILHAGTDRTWPDLAHHTISFGTAWKSTFHELT
                     RTGELMSDPSLLITRPTASDPSLAPPSKHLHYVLAPCPNTEVGPGVREWRELGPRYRDE
                     LLAELERREMPGLGAAIEEEGLVTPVDWTARGHAAGTPFSVAHTFPQTGPFRPGNLVRG
                     TVNAVLAGCGTTPGVGVPTVLISGKLAAQRIAGPPSVPRPRPRGSAA"
     gene            12777..13805
                     /locus_tag="C6W96_RS01445"
                     /old_locus_tag="C6W96_01440"
     CDS             12777..13805
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606404.1"
                     /locus_tag="C6W96_RS01445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01440"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_107409908.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.2e-116,
                     bitscore: 387.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.5e-69,
                     bitscore: 233.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARELDAAGIRDAALRAAYTRCRGLNARHGKTYFLATRLLPVDR
                     RPAVHALYGFARWADDIVDDLGSTATPGERARALVALEAQLAAGLRHGRTTEPVIRALA
                     DTAGRYGIAHQHFADFLSSMRSDLTVGGYASYEELGRYMHGSAAVIGLQMLPVLGTVGP
                     REEAAVHAAALGVAFQLTNFLRDVGEDLDRGRLYLPSELLAAYGVDRERFEWSRRTGTR
                     DGRITDVLRAAAAHNRAVYRAALPGIAMLDPVSRPCIRTAFVLYSGILDAIEADGYAVL
                     HRRAVVPRRRRAAVALDGLARAVAVRTVGRRRERPVAGTRFFTASRPRVAETASAVRKE
                     TV"
     gene            13802..14812
                     /locus_tag="C6W96_RS01450"
                     /old_locus_tag="C6W96_01445"
     CDS             13802..14812
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456523.1"
                     /locus_tag="C6W96_RS01450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01445"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_107409909.1"
                     /transl_table=11
                     /translation="MSPATGRPRRIPLRLRSAPVPWERQAPTWRDAKPALIAQALKRAQ
                     NRPSGNWYVIGASRGLPPGRTLGVTVGSTEVVAWRNGEGKLHAGPGACPHLGAPLRDSP
                     VRCGTLVCHWHGLALDGGPFPGWEPYPAFDDGVLLWVRLDGLGQEPPSERPYVPARPGV
                     REAVETVYSGVGRCEPEDVVANRLDPWHGAWFHPYSFVDLTVTGTPADRPDDDDGFTVD
                     VSFKVAGRLVVPVRARFTAPEPRTVVMHIVEGEGAGSVVETHATPLAPDAQGRPRTAVT
                     EALVAASDRRGFAVARAAAPLLRPLMRTSAGRLWRDDLAYAERRWQLRDSGQFPG"
     gene            complement(14863..16422)
                     /locus_tag="C6W96_RS01455"
                     /old_locus_tag="C6W96_01450"
     CDS             complement(14863..16422)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010064443.1"
                     /locus_tag="C6W96_RS01455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01450"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_234389178.1"
                     /sec_met_domain="DAO (E-value: 4.5e-10, bitscore: 38.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILLRGGGRDDRRVRDRQAALVPAPAGRPRFTGEAPAVAVVGGGI
                     AGIAAATLLAERGARVTLYEREPGLGGRLAGWPTELADGTTVTMSRGFHAFFRQYYNLR
                     GLLRRIDPDLGSLTRLPDYPLRHSSGLHDSFARIPRTPPLSAMGFVALSPTFGLRDLIR
                     MNPRAALPLLDVRVPEVYDRIDSISATDFLNRIRFPEAAHHLAFEVFSRSFFADPQELS
                     AAELVLMFHIYFLGSSEGLLFDVPDEPFPTALWDPLLRHLESHSVRVRTGCPVREVRPL
                     LGSGLDISTDDGTDRHDALVLALDSGGLRRVVAASPDLGDADWRSRIARLRTAPPFLVS
                     RLWLDRPVARDRPGFLGTSGYGPLDNVSVLNRWEGEAARWASRTRGSVLELHAYAVPPD
                     ADRSAVQHAALRQLHQVYPETRSARILDERHEWRADCPMFPVGGYRDRPGVRSPDPSVT
                     VAGDIVRTDLPVALMERAATSGFLAANALLEAWGVRGQTLWTVPRMGRSALLRGLAALG
                     PS"
     gene            complement(16419..17147)
                     /locus_tag="C6W96_RS01460"
                     /old_locus_tag="C6W96_01455"
     CDS             complement(16419..17147)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998483.1"
                     /locus_tag="C6W96_RS01460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01455"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_107409911.1"
                     /transl_table=11
                     /translation="MTLLRGDALSAAFDRGSAAYDCLVAASPGYHAHLRRSARRLGLAE
                     EGRGLSVLDLGCGTGASTAALLAAAPHARITGVDASGGMLDRAKAKSGLGNVNFVHAPV
                     EELADRLRPGSFDAVFAGYLFRNLVDPDKTLDLVRNLLVPGGRIAVHDYTLSGSTVHRA
                     AWNAVCTVIIQPAGRLAGDAELYRHLRDSVTRFDTAPAFAQRLRRAGFADVRVSPLPGW
                     QTGITHTFTARTTAGAGEGP"
     gene            complement(17144..18391)
                     /locus_tag="C6W96_RS01465"
                     /old_locus_tag="C6W96_01460"
     CDS             complement(17144..18391)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007456529.1"
                     /locus_tag="C6W96_RS01465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01460"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_107409912.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 4e-108, bitscore:
                     360.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPADFDVVIVGAGAAGLSLAYHLCAPGRATPLSVALVDAPPGPLR
                     APPRTWCFWEPPGGDYDSCLAASWRQLRVRASDGSCTVSRLGQLRYKMLRSDAFEALVE
                     QRLSRTAALCRIEADVSAVRDVPSDGGEVLTQDAHGESVLVRGRLVFDSRPPPRLPPAR
                     TTLLQHFTGWFVRTERPLFDPATADLMDFRTPQPAHGLSFGYVLPLDAHTALVEYTEFS
                     ASPLDTDGYRRALYNYTGKIMKLGQLHVTAQEHGVIPMTDGHFSYRQGRSVFRIGTAGG
                     ATRPSTGYTFAAVQRQSRAIAAQLRAGRPLRMPLPYGRRARAMDAVMLRALDAGRVEGA
                     DFFSRLFRGVPAERLLRFMDGSSRLHEDLLIGLRTPVVPMLRTVVELPVRPRREQPDTL
                     ASPSPISPTGHEESTP"
     gene            18823..19692
                     /locus_tag="C6W96_RS01470"
                     /old_locus_tag="C6W96_01465"
     CDS             18823..19692
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020207303.1"
                     /locus_tag="C6W96_RS01470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01465"
                     /product="hypothetical protein"
                     /protein_id="WP_107409914.1"
                     /transl_table=11
                     /translation="MEPVDGVPYGRPVIIKTGDPRSLGVPASEARLNFDTELQELGGGP
                     RRRLLMVDDEPAFELSFYCGTCPLLFRRLETAREKLSLESMQERLTGTLDDPDDGGVID
                     AFGMLLPKGEYLPLLLEVEPRLVIPGKEGDYFSGEQVTTWGIDQFWGLPEYPHTPYYRT
                     FETAVDADAHLYEFVVPMVPPTWNERERVEEYIALMEQGTVPTVVAISTLDVCQPAIDR
                     GDDYFVHWGLTHFLLDGHHKLEAAATAGRPVRLLSLLTLGESLAGAEGTARLPALRTQS
                     RTARRIGR"
     gene            complement(19756..20208)
                     /locus_tag="C6W96_RS01475"
                     /old_locus_tag="C6W96_01470"
     CDS             complement(19756..20208)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072005.1"
                     /locus_tag="C6W96_RS01475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01470"
                     /product="hypothetical protein"
                     /protein_id="WP_107414744.1"
                     /transl_table=11
                     /translation="MSTDVSGMIECRPGAHLWSPDDEDSVWEVAIDLFLLNRGNAYDGL
                     ACLFGIRNSYGFRPLAEDRGFPVDASDGLRAEFAGYGGPHDVYGTTWLTWAELDTTDWQ
                     ETNSSGTRTRASAAGDDTDWGRVWSVMRILSEVHGAEHVRLVVWFH"
     gene            complement(20279..21763)
                     /locus_tag="C6W96_RS01480"
                     /old_locus_tag="C6W96_01475"
     CDS             complement(20279..21763)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018259.4"
                     /locus_tag="C6W96_RS01480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01475"
                     /product="TniQ family protein"
                     /protein_id="WP_107409916.1"
                     /transl_table=11
                     /translation="MNTPLPRSLDPAPGELLPGYLLRLSHRIGISPGDLAHRCGLIQGN
                     RLPTQPLVRLDADQAQQIATVCRLETTEVHGLTLAGQAPGYSPLGAVYLGQRQSPMDMA
                     NSGWVFTTFSRYCPDCLADTADFPGGPVWQGSWRLPHIFVCSRHNRHFSWRCLACGAPA
                     FSNGYRADGRWRPSQLVPGLRLRLHPAQCRHRPAGGWETACGAHLDHSPAAFTPPTTAA
                     AHAQRRLATATAAGPEGDIKSLGQPASPEQFFNDVRTTVLAICSTWPAAAEVFPAFEHL
                     DAIAAHCQALRRSPTERLRGQSDGWLARSIDHPPADSRQCAALMSLVVQVLDDPDGSAA
                     LTRLLSRLPPGRSGRLRTLTPHCSPAMSAAIAEATRLQQEACGPQPLFPQPPTHRGRLD
                     PRAISDPLPNAWAAPLAGLDGPARLLRRDAAIRLVQMARGGSRTSAGRYLGIPPGTLQS
                     TTLRVRTWQKLPGNAEAYQAALQHVAEIIMAAPEHG"
     gene            complement(21760..22929)
                     /locus_tag="C6W96_RS01485"
                     /old_locus_tag="C6W96_01480"
     CDS             complement(21760..22929)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969233.1"
                     /locus_tag="C6W96_RS01485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01480"
                     /product="TniB family NTP-binding protein"
                     /protein_id="WP_107409918.1"
                     /transl_table=11
                     /translation="MTGDLRRDALAGWEVWRLSRHSFEPAPRISPARWRTMPAAEKAAW
                     DLARAATHANLPLLGTPMSQAVGRLLAARIRQNAFKARPATRAGVMVSGGGYQGKTETV
                     CEIAAAFEDSWRDLHRTNPETVPGSRDLWAPVAYVQTPVTAKPKSTCKAILDFYGAPTK
                     RMDLPELIHQVAASLSDHGTKVLILDDITRLRMHRADDQDTLDLIRAFMSMHVTLVLVG
                     VGIPGSGLLREGRGPAAAKSANGWEPTQTERRFDLVELDRFRYDTAEQITAWTSHLAGI
                     EHHLRLLKARPGMLTDNTMPEYLYERTNGVVGLLERLIEDGCSQAIASGSERLTRPLFD
                     ALPLTLAGTGRDAEAGEIPAVPARSGRRPPTSRRRNTVFDDLGPAADTA"
     gene            complement(22926..24815)
                     /locus_tag="C6W96_RS01490"
                     /old_locus_tag="C6W96_01485"
     CDS             complement(22926..24815)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C6W96_RS01490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C6W96_01485"
                     /product="DDE-type integrase/transposase/recombinase"
                     /protein_id="WP_159103526.1"
                     /transl_table=11
                     /translation="MAKVAELGALPETEAARLGLESVSERTLKRMAARYRESGLIGLAD
                     GRWTRQAGGHPSVTADVEEAIRAVHEQCLRRSRISMASRERLIHQYVREVFPDRQVRVP
                     HRTTLARVWREWFGPGGSRQRYVRSAAAVPAPAGVPVIASRPGQVVVLDSTPLPVKVLD
                     DVFGTPITVHLTIALDAYTHSIVAFRLTPVAESSIEVAMLLRDVLSPLPMRPGWGATMA
                     WPYPGVPAALVADLAGGPVAGLPFFTPEAITVDHGSAFKNHHLVQVARTLGVDVLPARA
                     MRPTDKAACERAFAAIQSLLLELLPGWRGIDVADRGADPEADAAWTVAEMEHLLASWIV
                     SVWQNRRLDQHAPAWDPSGRHSPNTLFAAAAARDGIALEIPAPELYYELLPVHFVKIDA
                     RRGVKVGGLWYGAHSPALDPCRGVPAPRGGRHAGKWAVRRDPRDCRQVFIELDGTWHPL
                     PWNGLPPEGTVPAFGDARVGEVLKEAARSGLRPRTDTELLPVLLDLLAEVTPVEGWPGR
                     PEARKRAAARARELARARAATADRPDDRPPTAPAAQSAPRREVEDAITTDRLRRRRAAT
                     GGARPVPAARLGDGLAARTLYPTARPEPHADLDKLERPDSDRAESIKHDGGTA"
     gene            complement(25007..25816)
                     /locus_tag="C6W96_RS01495"
                     /old_locus_tag="C6W96_01490"
     CDS             complement(25007..25816)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143534.1"
                     /locus_tag="C6W96_RS01495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01490"
                     /product="TnsA-like heteromeric transposase endonuclease
                     subunit"
                     /protein_id="WP_234389179.1"
                     /transl_table=11
                     /translation="MTGTDQRAVWSHCCGFDELVVPYAVMCGEALDPRRDWTARWTVTW
                     QVDGSDIVCPVRDLATFPWTRAQPVRAFSWRPGQRHRPGLAFMGATGRGHGFESLAERR
                     ALTVLDFCGQVRDVLSQPFRLRFLDGARRTHIPDFLVATAGATLLIDVRPAHLVKESDV
                     TVFAATGRVAASAGWRYLVVTGWRNNVADTVEALARGRRRHTDPLGLEDQLLGAAVRPR
                     RFGELVAATSWPVLARDHLQRLLWKRRLAFDLNGPLGDGTWIYPVGP"
     gene            complement(26281..26667)
                     /locus_tag="C6W96_RS01500"
                     /old_locus_tag="C6W96_01495"
     CDS             complement(26281..26667)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010056217.1"
                     /locus_tag="C6W96_RS01500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_01495"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_107409921.1"
                     /transl_table=11
                     /translation="MGHGRDTTISASTRERLDAVGAADVAATLQALATPSRLYILTRLQ
                     EGPCSVSDLAEAVGMENSACSHQLRLLRNLGLVTGERQGRSIVYSLYDNHVAELLDQAL
                     YHVEHLRLGLHDTSAREPAATAGR"
     misc_feature    27097..27111
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.34"
                     /tool="antismash"
     misc_feature    complement(27751..27765)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.61"
                     /tool="antismash"
     misc_feature    27752..27766
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
ORIGIN
        1 gaccgcagcc tcgatgtaga tggccgggat ggcgactttc agtggtcgtg acggcgtcag
       61 gggcgcgtgc gaggcgggca catggtgatc cggtttgtgc ggtgcccgtc ggaacggctc
      121 ccgcccgccg cccgcagagt caccgctgcg ggcggcagtg gccgacaccg tgtcctcgga
      181 agagtccgag gacacccaga cgatgccggc caccagagag aacgtcacgc tcagcgtcat
      241 cgtgagacgg cacgcgcgcg tcggccctcg tcgtcgccct cggcagcgag agttacgcct
      301 cgccacgggc acggcgacgt gcggaccggc gcatcatgat cagacctgcg gcacccgcag
      361 ccccagcagc cagcacggca ccggtggttg ccgcgttcga gccgctctcg gagctgacgg
      421 gctccatgtc cgggacgccg ccgccgcccg cagggacacc gccgatgggc tgctgcggct
      481 tgtgcggctt gctgccgtgg ttaccgcggt cgcactcgac cttgaagctc cgctgcttcg
      541 ggcccgcggg gacgacccac accagctggt aggtgccttc cgggagcagg tacgcctcgc
      601 tccgcgcact gccgttgatg agcggaagcc tgtccatcag ggtggtcccc ggcggcacgg
      661 tcggaggctg ctcggtgatc gtccagggga ccgaggggaa cgactcgaag ttgctcgccg
      721 acagcacgaa cttgcagacc tcgacgccgt cgcggcttga gtgccagctg accgagcgga
      781 cgtcgatgtt gccgctgtcg ccgggggcgg cgtacgcggc gggcgctccg gccagggagg
      841 cgccggcgac cgcgacggcg acggcgacct tggcccccgt gcgggcgctg cgggggcgga
      901 cggaactgga gatgcgcatg gaggctcctt caagccgaga tgattgtcgt actgatcacc
      961 tgatcaccta aggagtgcca tgaaaagtat taaaagtctg ataagacacg gacatatgcc
     1021 cacaagaatt ccctgatcgg ccgacaggga gcgagtggaa gccaacgcac ggagcgctgc
     1081 gcgggacggg aaggccggtg cccgggcgcc ccggccgctg acgtggtcac gaaggcgtcc
     1141 ttgtccgacg tcaggacggt gtgtgtctcc acctgcacgt cccatccggg ccgaccgaag
     1201 ctcatggtcc aggccgattc gccccgcacc aaggcgaagt cctcagccac ccggctgcag
     1261 cgttcgcacg cacgcaggcc gacgtcgatg ccggcgccct cgtaccgtcg gaccagcctc
     1321 aagcctgagc gactgccgag ggcgaggtca ccctcccggg cccccgccgt cgttcctcag
     1381 caggcgagcg atcaggcggc cggggtgcag agcacggcgt cgtgctcgca ccgcctctcg
     1441 ccgtggacct gcagcgcttc gagttcgcgg tcatccgcgg tgagctgccc gggggcgcgg
     1501 tccgttccgg agacgatcct ccgggcagca ccacggggcg gccccagcgc ggggcccggt
     1561 gccggggcag ggccgccgct ctcagctcac gtcggttcag ccacccccag ctcgatgtgt
     1621 catccacaga tggcggggaa ctccggtggc aggacggagc ggcgacgcat cctatggggg
     1681 ccggtccggc cagggctccc ccgttccggc gacgcgccgg gggggccgcc cggccggcta
     1741 cccgaggcgg ggcagggctc cgagttcggt gacctggcgg gcgacttccc ggagcttgac
     1801 gttgtggtcc tgcgagtggc ggcgcaggac gttgaaggcc tcgttctcgg ggacgcgatg
     1861 tctggccatg aggatgccca tggcctcgcc gatcacatgc cgggtcgcca ccgcttcggt
     1921 gagctgggcg tggttgcggg cactggacag ggcgacggcg gcgtgggagg cgaggaccca
     1981 ccctgccgtc tcgctggtct cggtgaaccg gcccgggagc cgcgagtaga ggttcagggc
     2041 accgaggttc tcctcgtcag cgaacagcag gaagcccatc atgctgccga tccccagctc
     2101 agcagcctgc ggagcgaacg cgggccaccg ctgctgaagc tcggtcatgt cggcgatccg
     2161 gaagacccgc tccccatctc ggcggcgcgt cgcgtcgaag cacggcccct ccttcaggcg
     2221 ctcctgcaac cggtgactct cctcggccat cggcccggtc gccgccagcg tctgcacccg
     2281 ctcgccgcgc aggatcagaa ttccagcagc gtcgcacccc tcgaccagct ccgtcgccga
     2341 agcggcgatc cgatccagcg tcccggccac cgagtcctgc tccaacagat cgtgcgccat
     2401 cgccgccatc cgccgcgcga aaatctgcca gtccataccc atcccgaccc agcctcctgc
     2461 aagatccagt ctcgtcggtc caaccaccga gacacgtgcc ccgaggccca gacactcacg
     2521 cacgtgctcc ccgccacagc cgccctcgcc aaacgccccc gggcagcccc gcgacgaccc
     2581 ggcacacccc ggccgtgaag gctgcacatg gcacggaaga gcagcggcgt cggtcgcgtc
     2641 gggcccgggg gagcacagca ctacgcgtac ggaacccacg cgcggtgccg gccggggggc
     2701 ggctaccccg tctgcggagg ggtgcggatt ccgtccagga ggtaggtggt gcggcggtcg
     2761 tagtcgtgcc ggggaggcag ctcgccgtgc ttgagggcga gggcattgtc cacaacgagc
     2821 gcgtgcaggt cgctggacgt gaactccggc cgcagcacat cgcgggcttg cgccgccgcg
     2881 acgaactcct cgttggcctc gctgccccgc cggcagattt ccatcagctg ctgtgaacgc
     2941 gggtacgtcc gcagcagcac gtcgttgaag gcgggctggc ggtactggag gtcgcggagc
     3001 gcggtgacgt agtacacgat ccgctcgccc acgtcatcga tagccctggc gtggccgatg
     3061 agggcgaaca gctcacgcgc cacgagttct tcgatgacgg cttcgatgag gccgatccgc
     3121 ccaccgaacc ggttgaagat cgtggccttg ctcacccctg ccgccttggc gacctcctcc
     3181 agcggcaccg tcagcccctg cccctggaag gcgctgatcg cggcagcgcg gatctgttcg
     3241 gagttacgcc gagcgtcggc gcgcaggcgg gatccccgag gcaccgtact caccgtccca
     3301 ccctgcccct cgacacaagt tgactcatga ggtcagctta cctacggtcg aggggtaaac
     3361 gaaactgacc aaggtggtca gtttatggtt ccgaaaggta caagaacatg atcgttgtga
     3421 ccggtgccac cggagggctg ggcggcacca ccgttgagca cctcctcaag cgcgtacccg
     3481 ccgaccggat cggcgtcagc gtccgcgaca ccgccaaggc tcagcacttc gccgaccgcg
     3541 gcgtgcgcgt gcggcagggc acctacgagg acccggcctc gctgcgccac gccttcgccg
     3601 gcgccgaaca gatccttctg gtgtccggta acgacccggg cgccgacatg gtcagcctgc
     3661 accgcaatgc catcgacgcc gcagtcgcgg ccggcacacg gcgcatcctc tacaccagcc
     3721 agcagggcgc cgtccccggc aacccgtacc ggccctcgga catccacatg gccaccgagg
     3781 cgctcctcgc cgactcgggc gtcgcctgga ccgcgctgcg caacggcgcc tacggcccac
     3841 tcgaccaggt actcggcccc tggcagcaca ccggcgtgat cacccagccc caggacggcc
     3901 ccgtccccta caccgaccgt gccgacatag ccgaggccac cgcggtcatg ctcgccgcac
     3961 accactccct cgacggcccc gtcgacctca cctcgccgga cgccatcacc ttcgacgatg
     4021 tcgcaaggat cgcctccagg ctcgccggtc accccgtcga gcgcatcgtc gtggacgacg
     4081 agcggtggat cgccgaccag accgcggccg gcgtcccgga gcaaatggcc cggctcatgc
     4141 tcacctggta ccaggctgcc cgcaccggct acttctccca gaccagcgcc ctgctggccg
     4201 aactgctcgg ccgcaagccc ctcaccgtca ccgaccggct cggccgggac ctcgatcgtc
     4261 gggggccccg gaggtcggag caaccgcaag cctgagcgac cgacgggcgc gcaacccagt
     4321 aggggtatgc cgccaggcgg gccgagaggt atcgcagcct cgacctggcc gcccacccca
     4381 ggggagcccg ttgcccgtcg atcagctcgg catacgtccg ttcccagtcc gcttgcagga
     4441 gtagctgtga ctgagcgtcg tagttggccc gtccggccag atacacgctc agtactcgat
     4501 ggagcccgtt gacggcgtcc cgtacggtcg gcccgttcgg ctccgtggac ttcgctgagg
     4561 atgcgcatga cgctccagac gcggccccag tcggtgtcgt cgccgaacct tgcgttcccg
     4621 ccgctgagca tcagacgttc ctgaaactca cctacaaagc caccgccgta tgggcacggt
     4681 cgaacccctc ctcgtggaag actcttccca cgagtcgcgg aatgaggggc ggggctttga
     4741 gaacgcggtc ggagatacgg gcagggcagc ggacaatcgt cggcgaccga ggcggggtga
     4801 cggccttatc ggccctggct ctggcggtcc tcctgagcgc ctgcggcggc ggatccgccg
     4861 atcgggccgc tcctgacact cctccggtct ccactcctgg tacgtccggc gccccgaaat
     4921 ccacgagcgc ctccccccgc cccgagcagt ccactcccac caccgaccgg ccgccgtcct
     4981 ccggcggcag cacttcgatc aacctggacg cggtcgcgct gaaggacggt gacctggccg
     5041 agttccggct cgtggacgtg ccgtccaccc ggagcgattc accgggcacc gtcgctcccg
     5101 ccgcctgccg cgtcatcgcg gacgcccgcc gcgagtcgta cacgccgacg ccctccaccc
     5161 tcgtacggcg ctacgccgtc gcaacagccg gggaacacct gggcatcggt acgcagatca
     5221 ccctcgccgg caccaccgag tccgcggccc gtgatcttct cgacgcactc cgagccgccg
     5281 tcacggcctg tcgggacggc tacaccggtg acgggcgcgg cacgacgacc gtcacggcgg
     5341 tcaccccggt agccgtcgga gatgaaggcg tggccttccg tacggcgggc cgtggaatcc
     5401 cgacggagta cacgttcgtc cgccagggct ccgtgctgct gcgcttcgcc gcgtcctcgg
     5461 ccagagggaa gccggtgggc gtcccgagcc cggtcgtcgt ccagcaggtc atgaaggtgc
     5521 gcgccgcgac cgactgaggg acagcccgac cgggattcgg gctcttggag ggaaaactct
     5581 cgtgtgggga tgtctgctgg tccttctcac cgtcgggctg gtcgggaaac tgctcgtcgt
     5641 tccgctgacc acgtcggacc tgatggcggc gcagaccccg gcgcagcagc ccacgtggtg
     5701 gcaatgggcc gtactggtcg cgatctccgt cgcgacggcc gtggcggtga cctggtcggc
     5761 cggacgccgc cgtccgggcc gagccgggac cgtcgccctc ggtacggtcg ttctgctgac
     5821 cctgtgcacg gcggtcacac tgtgggtccg ggcccgcgtg ggcatcgaag actggacgtc
     5881 ggccgccacc ctggagagcc tcgtcgcggg agtggtcgcc ctgtccttcc gggcagggtt
     5941 ccggcggtgg gagcgggggc ggcccctcgc gggggaggtg tggctcgcca tggtgcccta
     6001 ccgagagcgg gacgaggcgg cacgccacta ctgcgtcgtc cggcgccgcc gcctgcgtgg
     6061 cgcggacgtc ctccagatca cctcgcagaa caaggacggc caggacggat acctgcccat
     6121 gcccaacggg ctctgggacg tgacatcggg gaaggcacat tgggtggaga ccacgacgcc
     6181 gcctcgtcgg gtgccgtatc gggacttcct caaggaccgg cctcaagggc cgtgccctcc
     6241 cgcgacctgg cgtctgctgc gcaggccgcg gcccgctccg gccagtccac gcctccgccg
     6301 tcgaagcgga cggggaacca agacagctcc ctgaccgcga acacaaaccg ttcgagcgaa
     6361 cgccgctttg gtctgcgcag tgtccctgct atccacgcat ccttctgaga gcgctgggcc
     6421 tcactctgga ttccgagcaa agcccgcacc atccctgcga tgtgggcgca acgtcacatt
     6481 ctccgcccgg tttgccgccc tctgcccggc caccggcccg ccggcctctg gtggcagact
     6541 ctgctcagcg gtcccgggga gagagcgtga acaggcctcc gtccgggtcc tgcagagtgc
     6601 gcgagaaccc cgcaggcgcc caggaggccg gcgaaggctg aggcctggcg ccgccggcgc
     6661 tcagggcggc ggacacggcc cgctcaacgt catcgacggc gaagttcacc agccagcgag
     6721 gccgcaaatg agccagtgga gaggtctgca cgccgccgcc ccgcagggag agaatcacgc
     6781 ggtcccggag cttcaccaga acatgatcct tccggtaggc aacgacgacg tcctccgtgc
     6841 caccgagaac gagaccgtcc tggacgccgc gaagaagatg aaggaccttg gcgtcggagc
     6901 cctgccgatc tgcggagcgg acaataggct caagggggcc acgggacgct ttcggctccc
     6961 gtgctttcat ctccgcgctt ttctgcggcg ttgccccgcc cttgtcgctg cgccgctgtt
     7021 ccggctcttg agcgagtact tggagggcgg tcacaggagt agtgcgtagg ccaagaagaa
     7081 gcccgccacc agggcggcga ccgtcaggat ggcgatgagc ggccccatgg cccagccctt
     7141 gctcgtctcc tggcgaggcc ccgcctcgga cgtactgctc tcgccgggcg gcgtatcgcc
     7201 cggggacact ccgccgccgg gttccaggcc gggggtctcg cgcgggtcgg ggtcgggaat
     7261 tcctgtactc atgcgctctg ggtacccctt cacaccgatc cacacctggt ggcaccaggc
     7321 gggccccgcc cgaaccggga tcagtcgttc caggagctga agcatctgct cgccggtgcc
     7381 gccccgggca ccggcgaggg cggagcctat ctgcgtcagc cggcgagaaa gacggccgcg
     7441 aagaagcgca gtgcctcctg accctcctcc tgccgcaggc gccgtgctgc cgaggatcga
     7501 gccgatgctc gcaacgcccg gcccgctgcc gtcggcgggg gtggagaacc ggtgggcgtt
     7561 cgaggtgaaa caggacggcc aacgggccat gatctacctg ccgggcgacg gcacgatcct
     7621 cctgcgcgct cgttcaggta cggacatcac cgccgcctac cccgaactca tcccctcgcc
     7681 gacgccctcg gcgcacaaag cgccgtgctg gacgaggaga tcgtcgcgct cgacgatcag
     7741 ggccgcaacg acttcgaacg cctccagcag cgcatgggcc tcgccggtgc tcccgcgaag
     7801 gccgcgcgga tggtgacctt ggtgcccgcg catctgatgc tctgcgatgt cctgcacctc
     7861 gacggccgac tcgtgaccgg gctgcctcga cgagatgggt cggcagcgga tgctgcggct
     7921 gggacgcgga gcggcgagtg ctgctggaag ttctcgaact ggtcgggccc gcctggtcga
     7981 caccctcggc gatcaccggg cacggtgccg aggcgtggga gatggcccgg gaggccgggc
     8041 tggaggggct gatcgcgaaa cggctcacct cccggtacga gcccggcgca cgctcgaaga
     8101 cctgggtgaa gatcaaagtc caccggctcg ccgacgtcgt gatcggcggg tgggtccccg
     8161 gccacggacg gctgaccggc ctgccctggg ccgtcctggt cggcgagcgg catgacagtg
     8221 tgctgcacta cgagggcagc gtcggcaccg gctggagccg taccgaacgc acccgcctcg
     8281 ccgaactcct ccaggccgcg gccgccgaca cctgcccctt ctcacaggct cccccggcgg
     8341 ccggggccca gtgggtactc ccccagctcg tcggtgaggt ccgctacacc tcccgcaccc
     8401 gcgccggacg cctgcgccac ccctcctggc accggctacg ccccgacctc accccagacg
     8461 actgtgactg agcgcggtgg atggtcccga cggacaactt cgatgcacag aacgcgagca
     8521 gacgggcggg cgacgaggca tcggctactc gtcgctcagc ttgttctcta accgatcggc
     8581 ggcggtcgtg accagcagca ggtcttcgtc ggtgtccgcg cagcgaccgt ctgagccgcg
     8641 cccgtttcgc gtaggtcccc gcaagtttgc ggcccgcccg ctggtgctgg gcaggggcgc
     8701 gctgagccct cgtagtctgc cgcacgagcg tgtcaccgag cggcgaatac tttcgcgcaa
     8761 tcttcgcagg tgaagagacg tgaatgcgct gtgaaaggaa ctggtgactg gacggtgcag
     8821 cgaaacgtgc ggcctgaccc gcatgctggg cagagacgcg cagcgaaggt ggtgtcgcac
     8881 gcgcgacaca gccagtcggc cccggaagca tccgtacgat cagaaccaca ggcgggacag
     8941 cgtgccgcat ccggcaccgg taacgtcatg gcgctcctca ctcgatgcgc tccgtcgcag
     9001 ggtctgccag gagagaccgg cgtgcacgtg cagttgccgc gacgaccaca agacaagctc
     9061 ccactgttca acacattcga ctacagccca gagcagcctg tgcttgtaca agccgtagtg
     9121 tccggacggt ctcgccctcg cacagagcaa caggcctccg ggagcggcaa accgatagca
     9181 tcggcccttc caccaggatc gggccttccc ggttcaccac cgcgcggcgt ggtgtctcat
     9241 tggcgggcgc gctcacgttg atcggagaga gccgcgagag ctccgatggc ttcagcttca
     9301 ggagcccttg ttcttcttcc gcagagactg cggcttatgc acagcggttc ggccggactt
     9361 ttcactctca acctcctact gcggttctgc ttccgatgca ttgaccgtgc gtccggcgac
     9421 ctcaccgcgc tctgtgatct ttttcttcac cttgccggga acggtctgcc cgtgactgct
     9481 ccaggagact gagtcccctt tctttagttt cttgcctttt gccatgatgt gcacgctccc
     9541 tgagtgtcat ccgcccacgg cggctataga cactgttgcg cccgttgcgg tcccacgcat
     9601 tccggcacga tcgcagcagg ctcagggtgt gaagccagac agtgctcgag tcgcggcgtt
     9661 ccgtgggctg aggcaggttc cttgttgaca gcgtcagtgt ttcggcaacc gggctgtgcc
     9721 gagaaggaac acagccccga tccggtgggc agtccccatc gggtgtgtgc ggagcgggcg
     9781 tccgtcacgt gggccatacg ggcgtggtgg ccgccgtcct gtcgtgtccg gggtgttttt
     9841 cctccgggag ccggcggctg gcgtgatcgt ctctgatcag tgcctgcttc cgcgcggtgc
     9901 gaactcctga tcggcagtct gcacgaacgc atgcgaacgg ggtacgcgca gcggggtatc
     9961 gagtcgttcg tcatcaccac tgatctcgga aaggcgtgag atgggccgtt cccagcccac
    10021 ggagcactcg ctcggcgagc cttcgcaacc ggccggcaag tcgaaggagc accgccagcc
    10081 tggcctgtcg tccgaggacg cgcaggtcgt cgacgcggat gtggtccatg ctgtcctgcg
    10141 taccgcacgg gcagtgctga gtgaacgggt cggcgaggca ggtgagcacg acgtcttgtt
    10201 ctccgaggag ttggcgcggc gggtcgccga cttcacgctc gacggcggca agcgcatgcg
    10261 gcctcgcctt ctgtggtggg gaatgcgcgc gtgcggtgcg gcggagaccg cggccgctct
    10321 gcggctcggg gtggcgctgg agctgatcca gacctgcgca ctgatccacg acgatgtgat
    10381 ggaccgctcg cgactgcgcc gggggcagcc tgccgtacac gtcggtttgg cagagcatgc
    10441 ggggctctcg ccgcattccg agcgggggtc tgcgttcggt tcctctgcgg ccgtgctggc
    10501 aggggatctg gcactggtct gggccgatga cacggtggcg gagaccgtgc tgtccgccgc
    10561 ccagcgtcgg agaatcggca ccctctggcg ggccatgcgg accgagatga tcgccgggca
    10621 gtatcttgat cttcacggcc aggtcagcgg tgggtcctca gtggtgcaag ccttgcggac
    10681 cgcctcgctc aagagcgcct cgtattccgt cgagcggcct ctgatgctcg gcgccgccct
    10741 cgcgggagcc gatgagtgga ccaccgaagc actgagtgcc gccggccggt gcgccggtct
    10801 cgccttccag ctgcgggacg atcttctcgg ggtcttcggt gatccggggg tgacggggaa
    10861 gccgtccggc gacgacatcc gggaggggaa gccgacctac ctgctggctg tcgctcggac
    10921 gtgggctgaa gctgcgggcg acgaagaagc gctggccgtc ctcagccgcg tcacgggcaa
    10981 cgacgacctg acggaggacg atttcgctga cgtgctgggc gtctttgagg tgacgggggc
    11041 gcgcgcccat gtggagcggg aggcggagcg gcttcacgac cacgccgttc atcgtctggg
    11101 acaggccgtt gacgtggagg cgcacggcgg gcgtcagctg ctcggtctgc tgcgcacagt
    11161 ctccggagac tggtccggcc actcggcgct ccacaccggc gaaacggacg gggcggcagc
    11221 cgccgcccgg ctcctgactg cggccgaagg gggcagcccc aggtgattac ggtcaaggga
    11281 cccgtcgacc atgtggtggt ggtcggtgcc ggtctggcag gtctggccgc tgcgctccac
    11341 ctactaggcg cgggccgcag cgtcacggtc gtcgagcggg aagaagtacc gggcggccgg
    11401 gccgggctgc tggagacggg cggcttccgg atcgacaccg ggccgaccgt actcacgatg
    11461 cccgatctgg tggaggaggc cttcgccgcg gtcggggagg cgatggccga ccggctggag
    11521 ctgatccggc tggatcccgc ctaccgggcc cggttcgccg atggatccca gctcgacgtg
    11581 cacaccgacg gtgcggcgat ggaggccgct gtcgagcagt ttgcgggtgc ccggcaggcg
    11641 gtcggatacc ggcgcctgcg gatctggctg gagcgcctgt actgggtgca gatgcgtcgt
    11701 ttcatcgacg ccaacttcga ctcgccgttc cagctcgtcc acccggacct cgcccggctc
    11761 gccgctctcg gcggtttcgg ccggctcgat gcgcggatcg ggcacttcgt ctcggacgaa
    11821 cggctgcgca gggtgttctc cttccaggcg ctgtacgcgg gtgtgcctcc ggcacgggcg
    11881 ctggccgcgt acgcggtcat cgcctacatg gacacggtgg ctggggtgta cttcccccgg
    11941 ggcggcatgc acgcgctgcc ccgtgcgatg gcggacgcgg cagccgactc aggagcgtcc
    12001 ttccgctacg ggcagagcgt gacccggctg gagcgctcgg gtgaccgggt caccgcggtc
    12061 gtcaccgacc aggagcgcat cgcctgcgac gcggtggtcc tgacccctga cctgcccgtc
    12121 agctaccggc tgctcggccg cagcccgcgt cggccgctcc ccctgcggca ttcgccgtcc
    12181 gcggtgatcc tgcacgcggg cacagaccgc acctggccgg acctggcgca ccacaccatc
    12241 tcgttcggca cggcctggaa gagcacgttc cacgaactca cccgcaccgg cgagctgatg
    12301 tcggacccct cgctcctcat cacccgtccc accgcgagcg acccctctct cgcacctcca
    12361 agtaagcacc tccactacgt gctggctccc tgcccgaaca ccgaggtcgg gcccggcgta
    12421 cgggagtggc gtgagctggg gccccggtac cgggacgagc tgctggccga gctggagcgc
    12481 cgcgagatgc ccggtctcgg cgcggcgatc gaggaggagg ggctggtcac tccggtcgac
    12541 tggaccgccc ggggccatgc ggcgggcacc ccgttctccg tggcccatac cttccctcag
    12601 accggcccgt tccggccggg caacctggtg cggggcacgg tcaacgccgt cctcgcgggc
    12661 tgcggcacca cgcccggcgt cggcgtgccg accgtcctga tctccgggaa actggcggcg
    12721 cagaggatcg ccggcccgcc ctccgttccg cgaccccgcc cgagaggttc tgccgcatga
    12781 ccgcccgtga actggatgcc gcgggcatcc gtgacgccgc cctccgagcc gcgtacaccc
    12841 gctgccgcgg tctcaacgcc cgtcacggca agacgtactt cctcgcgacc cggctccttc
    12901 ccgtcgaccg tcggcccgct gttcacgccc tgtacggctt cgcccgctgg gccgacgaca
    12961 tcgtcgacga tctcggcagc acggctaccc ccggggagcg cgcccgggcc ctggtggcgc
    13021 tggaggccca gttggccgca gggctgcggc acgggcggac caccgagccg gtgatccgcg
    13081 cgctcgccga cacggcgggg cggtacggca tcgcgcatca gcacttcgcc gacttcctgt
    13141 cctccatgcg cagcgatctg acggtcggcg ggtatgcctc gtacgaggag ctcggccggt
    13201 acatgcacgg ttcggccgcg gtgatcggtc ttcagatgct gccggtgctc gggacggtgg
    13261 ggccgcgtga agaggcggca gtgcacgcgg ccgcgctcgg agtcgccttc cagctgacca
    13321 acttcctgcg ggacgtgggc gaggacctgg accggggacg gctgtacctg ccgtctgagc
    13381 tgctggcggc gtacggggtg gaccgggaac gcttcgagtg gagccggagg acggggactc
    13441 gggacggccg gatcaccgat gtcctgcggg ccgccgcagc ccacaaccgg gccgtctacc
    13501 gggccgcctt gcccgggatc gcgatgctcg acccggtctc gcggccctgc atccgtacgg
    13561 cgttcgtgct ctacagcggc atcctcgacg cgatcgaggc ggacgggtac gcggtcctgc
    13621 accgccgggc ggtcgtcccg cggcggagac gagccgccgt ggcgctggac ggactggccc
    13681 gggcggtcgc cgtgcgcacc gtggggcggc gccgggagag gccggtcgcg ggtacgcgct
    13741 ttttcacagc ctcccgtcca cgggtggccg agaccgcgag cgcggtgcgg aaggagaccg
    13801 tatgagcccc gcgacagggc gtcccaggcg cataccgcta cggctgcggt ccgcacccgt
    13861 gccgtgggag cggcaggcgc cgacgtggcg ggacgcaaaa ccggcgctga tcgcacaggc
    13921 cctgaagcgt gcgcagaacc ggccttccgg caactggtac gtcatcggcg cctcgcgcgg
    13981 tcttcctccc ggccggacac tcggggtcac ggtcggctcc accgaagtgg tggcctggcg
    14041 caacggcgag ggcaagctcc acgcgggccc cggggcgtgc ccgcatctgg gggcgcccct
    14101 gcgcgacagc ccggtccgct gcggcacgct ggtctgccac tggcacggac tggccttgga
    14161 cggcgggccg ttccccgggt gggagcccta cccggccttt gacgacgggg tgctcctctg
    14221 ggtgcggctc gacggcctgg gccaggagcc cccttcggaa cggccctacg taccggcccg
    14281 gcccggggtc cgggaggctg tggagacggt ttactcgggc gtcggccgct gcgagccgga
    14341 ggacgtggtg gccaaccgcc tcgacccgtg gcacggagca tggttccacc cgtactcctt
    14401 cgtggacctg acggtcaccg gaacgcccgc cgaccgcccg gatgacgacg acggcttcac
    14461 cgtcgacgtg tcgttcaagg tggctggacg cctggtcgtg ccggtgcggg cccggttcac
    14521 ggcgcccgag ccccgtacgg tcgtcatgca catcgtcgag ggcgagggcg cggggtccgt
    14581 ggtggagacg cacgccacgc ccctcgctcc ggacgcgcaa gggcggcccc gcaccgccgt
    14641 gacggaagcg ctggtcgcgg cgtcggaccg gcgcgggttc gccgtggccc gggcggccgc
    14701 gccgctgctg cgccccctga tgcgcacctc ggccggccgg ttgtggcggg acgacctggc
    14761 gtacgcggag cggcgctggc agctccgcga cagcggacag ttcccgggct gacgagcggg
    14821 cggtgcggaa cccttttcgt gaggccctgc gccgcccctc cgtcaggagg gccccagtgc
    14881 cgcgagcccg cgaaggaggg ccgaccgtcc catgcgcggt acggtccaca gcgtctgccc
    14941 gcgtacaccc cacgcttcca gcagggcgtt ggcggcgaga aacccgctcg ttgccgcgcg
    15001 ttccatcaga gccaccggca gatcggtgcg gacgatgtct cccgccacgg tgacggaggg
    15061 gtcggggctg cgcacgcccg gccggtcccg gtagccgccc acggggaaca tcgggcagtc
    15121 cgcccgccac tcgtggcgct catcgaggat gcgggcgctg cgggtctccg ggtagacctg
    15181 gtgcagttgc cggagcgcgg cgtgctgtac ggcggaccgg tcggcgtccg gtgggacggc
    15241 ataggcgtgg agttcgagaa ccgagcccct ggtgcgactg gcccagcggg cggcctcacc
    15301 ctcccagcgg ttcaggacgc tcacgttgtc cagcggtccg tagccgctgg tgcccaggaa
    15361 gcccggccgg tcccgcgcca cggggcggtc gagccagagc cgtgagacga ggaacggcgg
    15421 tgcggtgcgc agccgggcga tgcgtgagcg ccagtcggcg tcgcccaggt ccggggaggc
    15481 ggcgacgacg cggcgcaggc cgccgctgtc cagagcgagg acgagggcgt cgtggcggtc
    15541 ggtgccgtcg tcggttgaga tgtcgaggcc gctgccgagc agggggcgca cctcgcggac
    15601 ggggcacccg gtccgcaccc ggacgctgtg gctctcgagg tggcggagca gcggatccca
    15661 cagggcggtc gggaacggtt cgtcggggac gtcgaagagc aggccctcgc tggagccgag
    15721 gaagtagatg tggaacatca gcaccagttc ggccgccgac agttcctgcg ggtcggcaaa
    15781 gaagctgcgc gagaacacct cgaacgccag gtggtgggca gcctcgggga agcggatgcg
    15841 gttgaggaag tcggtggcgc tgatggagtc gatccggtcg tagacctcgg gcacccgcac
    15901 atccagcagc ggcagagccg ccctcgggtt catccggatc aggtcccgca ggccgaaggt
    15961 ggggctgagg gcgacgaatc ccatcgcgct gagcggaggc gtgcgcggga tccgggcgaa
    16021 gctgtcgtgc aggccggagc tgtgccgcag ggggtagtcg ggcagccggg tcagcgagcc
    16081 gaggtccggg tcgattcggc gcagcaggcc gcggaggttg tagtactgcc ggaagaaggc
    16141 gtggaacccg cggctcatcg tcacggtggt gccgtcggcg agctcggtgg gccatcccgc
    16201 cagccgtccg cccaggcccg gttcgcgctc gtacagcgtg acgcgcgcac cccgttcggc
    16261 cagcaaggtg gccgccgcga tcccggcgat tccgccgccg acaacggcca ctgcgggggc
    16321 ctctccggtg aaccgggggc ggccggcagg ggccggcacg agcgccgcct gccggtcccg
    16381 gacgcgccgg tcgtccctgc cgccaccccg caggaggatc acggcccctc ccccgcgccc
    16441 gcagtggttc gggcggtgaa ggtgtgggtg atcccggtct gccagccggg cagcggcgac
    16501 acgcgtacgt cggcgaagcc ggcccgacga agccgctggg cgaaggcggg cgcggtgtcg
    16561 aaccgggtga cgctgtcccg gaggtggcgg tagagctcgg cgtccccggc gagccgtccg
    16621 gcgggctgga tgatgaccgt gcagaccgcg ttccaggcgg cacggtggac ggttgatccg
    16681 ctgagcgtgt agtcgtggac ggcaatgcgg ccgccgggga cgagcaggtt acgtaccagg
    16741 tcgagggtct tgtccgggtc gacgaggttg cggaagaggt atccggcgaa caccgcgtcg
    16801 aaggagccgg gccgcagccg gtcggccagc tcctccaccg gcgcgtgcac gaagttgacg
    16861 ttgcccagcc cgctcttggc cttcgcccgg tccagcatgc cgccggaggc gtcgacgccg
    16921 gtgatccggg cgtggggggc agcggcgaga agggctgctg tggaggcgcc cgtgccgcat
    16981 cccaggtcga gcacgctcag tccgcgtcct tcctccgcca gtcccagccg gcgtgccgat
    17041 cggcgcagat gcgcgtggta gccggggctg gccgcgacga ggcagtcgta ggccgcggat
    17101 ccgcggtcga atgccgcgga cagtgcgtca ccgcgcaaca gggtcatggg gtgctctctt
    17161 cgtggccggt cggggagata ggtgaggggg acgccaaggt gtcaggttgt tcacgccggg
    17221 gcctgacggg gagttcgacg acggtacgca gcatgggaac caccggtgtc cgcaggccga
    17281 tcagcaggtc ctcatgcagc cgcgaactgc cgtccatgaa tcgcagcagc cgctcggcgg
    17341 gaacgccgcg gaagaggcgg ctgaagaagt cagcgccttc cacccggcca gcgtccagtg
    17401 cccgcagcat caccgcgtcc atcgctcgcg cccgtcgccc gtacggcaga ggcatgcgca
    17461 gcggccgtcc ggcgcgcagc tgggcggcga tggctcggct ctgccgttgc acggcggcga
    17521 aggtgtagcc ggtggagggc cgggtcgcgc ctccggccgt gccgatgcgg aacaccgaac
    17581 gcccctgccg gtaagagaag tgaccgtccg tcatcgggat gacgccgtgt tcctgtgccg
    17641 tgacgtggag ttgccccagt ttcatgattt tgccggtgta gttgtacaag gctcgccggt
    17701 agccgtcggt gtccagcggg gaggcggaga actcggtgta ctcaaccagc gccgtatgcg
    17761 catccagagg cagtacgtag ccgaacgaga gcccatgggc gggctgcggc gtacggaagt
    17821 ccatcaggtc cgcggtcgcc ggatcgaaca gggggcgctc ggtgcggacg aaccagccgg
    17881 tgaagtgctg gaggagggtg gtgcgagcag ggggcaggcg agggggcggg cgggagtcga
    17941 agacgaggcg gccgcgcacg aggacgcttt cgccgtgcgc gtcctgcgtc aggacctcgc
    18001 caccgtcgga cgggacatcg cgtacggcgc tcacgtccgc ctcgatccgg cacaaggccg
    18061 ccgtgcgaga caaccgctgc tcgaccagcg cttcgaaagc gtccgacctc agcatcttgt
    18121 agcgcagctg tccgagccgg gaaacggtgc aggacccgtc ggatgcccgg actcgcagct
    18181 gccgccagga ggcagccaga cacgagtcat agtcgcctcc cggcggctcc cagaagcacc
    18241 aggtccgggg cggcgcccga agcggccccg gcggggcatc gacaagggcg accgacagcg
    18301 gcgtggccct gccaggggcg cacaagtggt acgccagact cagcccggcc gctccggccc
    18361 ccacgatgac gacatcgaag tcagcaggca cggctccctc tcggtcggac gaacccccgc
    18421 tgatgtgcga acccgatgcc cttcccacca gcaggccggg cgagatgctt gctctccgac
    18481 cgtatcccgc tcgcccatac cggacccggc ctcagctgcg gctcccacct gagtggcgga
    18541 aaggcccgtc gaggtcggca gcctccgccc gcctgaccga tggcttgccg ctcaaacctg
    18601 ccactcataa gccgaccccg gagaacggtc aaccttcgct gcgacgggac atgtgggtct
    18661 cgttgccgtg atccggctac ccggccacac cggccctatc agtcaccggc ctgctcgggc
    18721 ccggggccaa ccggcctgct ccacctgtcg cgcacagtca caacaacact gtgactgagc
    18781 gtcgtagttg gcccgtccgg ccagatacac gctcagtact cgatggagcc cgttgacggc
    18841 gtcccgtacg gtcggcccgt gataatcaaa acgggcgacc cccgcagtct cggcgtccca
    18901 gcctccgagg cacggttgaa cttcgatacg gaactgcagg agctcggcgg cggaccgcgg
    18961 cgccgcttgc tcatggtcga cgacgagcct gccttcgagc tcagcttcta ctgcggcacg
    19021 tgcccgctcc tgttccgccg gctggagacc gcgcgggaga agttgtccct ggagagcatg
    19081 caggaacggc tcaccggaac gctggacgat ccggacgacg gcggcgtgat cgatgcattc
    19141 ggcatgctgt tgccgaaggg cgagtacctt ccgctgctcc tggaggtgga accccggctg
    19201 gtcattcccg gcaaagaggg cgactacttc agcggcgaac aggtcacgac gtgggggatc
    19261 gatcagttct ggggccttcc ggagtacccg cacaccccgt actaccggac cttcgagacc
    19321 gcagtcgacg cggacgccca cctctacgag ttcgtcgtgc ccatggttcc cccgacgtgg
    19381 aacgagcggg agcgtgtcga ggaatacatc gcactcatgg agcagggaac ggtccccacg
    19441 gtggtggcga tctccaccct ggacgtgtgc cagcccgcca tcgaccgagg agatgactac
    19501 ttcgtgcact ggggcttgac ccacttcctc ctcgacggac accacaaact ggaggccgcc
    19561 gccactgccg gtcggccggt gcggctcctc tcgctgctga ccttgggcga aagcctggcc
    19621 ggagcggaag gcaccgcccg gctgcctgcc ttgcgcacac aatcccgcac ggcccgccgg
    19681 atcgggcggt agatgtcggt acgtgactcc ggccaactac aacactcagt ggccaaccgg
    19741 ttgctcagct gcgagtcagt ggaaccagac gacgaggcgt acgtgctcgg ccccgtggac
    19801 ttcgctgagg atgcgcatga cgctccagac ccggccccag tcggtgtcgt cccctgcggc
    19861 tgaggcgcgc gttcgtgtgc ctgaggagtt ggtctcctgc caatccgtgg tgtccagctc
    19921 ggcccaggtc agccaggtag tcccgtacac atcgtgggga ccgccgtagc cggcgaactc
    19981 agctcgcaac ccatccgagg cgtcgaccgg gaagccacga tcttccgcca ggggccgaaa
    20041 gccgtaggag ttgcggatcc cgaagaggca ggccaggccg tcgtaggcgt tgcccctgtt
    20101 gaggaggaag agatcgatgg cgacctccca gacggagtct tcgtcgtcgg ggctccatag
    20161 atgggcccca ggccggcatt cgatcattcc gctgacgtcg gtcgacatgg agcgatcctg
    20221 cctgtgccgg tcaagggaag gcatctccat ttccctcgct cgcaggtggc atggggcttc
    20281 acccatgttc gggagcagcc atgatgatct ctgccacgtg ttgcagggcg gcctggtatg
    20341 cctcggcgtt gcccggcagc ttctgccagg tgcgcactcg tagagtggtg gactgcaggg
    20401 tcccgggcgg gataccgagg tagcggccag cgctcgtacg tgatccgccg cgggccatct
    20461 ggaccagacg aatcgcggcg tcgcgccgca gaagccgcgc gggtccgtcc agccctgcca
    20521 gcggggctgc ccaggcgttg gggaggggat ctgaaatggc gcgcgggtcg aggcggcctc
    20581 tgtgggtggg gggttgaggg aagaggggct gcggtccgca ggcttcctgc tggaggcggg
    20641 ttgcttccgc tatcgcagcg ctcatggcgg gtgagcagtg cggggtgagg gttctcaggc
    20701 gcccggacct gcctggcggg agtcgggaca gtagacgagt gagtgcggcg gaaccgtccg
    20761 ggtcgtcgag gacttggacg acgaggctca tcagggcggc gcattgccgt gaatcggcag
    20821 gcgggtggtc gatggatcgg gccagccacc catcgctctg acctctgagg cgttcagtgg
    20881 ggcttctacg cagggcttgg cagtgggcag cgatcgcgtc caggtgttcg aaggcaggga
    20941 agacttcggc ggcggcaggc caggtggagc agatcgccag gactgtagtg cggacgtcgt
    21001 tgaagaattg ctcgggtgag gctggctgcc cgaggctttt gatgtcgcct tcggggccgg
    21061 cagcggtggc tgtggccagt cgccgctggg cgtgtgctgc ggctgtagtg ggcggggtga
    21121 aggcagcagg cgagtggtcg aggtgggcgc cgcaggcggt ctcccatccg cctgccgggc
    21181 ggtgacggca ttgcgccgga tgcaggcgga ggcggagtcc cgggaccagt tgggacggac
    21241 gccaccttcc gtcagcccgg tagccgttgg agaaggcggg tgccccacaa gctagacatc
    21301 gccaggagaa atgacggttg tggcgcgagc agacgaagat gtgagggagc cgccaggagc
    21361 cctgccagac cgggccgccc ggaaagtctg cggtgtcggc gaggcagtcg gggcagtagc
    21421 ggctgaaggt ggtgaacacc catccgctgt tggccatgtc catagggctt tggcgctgcc
    21481 cgaggtagac ggccccaagc ggggagtagc cgggagcctg gccagccagg gtgaggccgt
    21541 gaacctcggt cgtttcgagt cggcagacgg tcgcgatctg ctgggcctgg tcggcgtcga
    21601 ggcggaccag gggctgcgtg ggcagcctgt tcccctggat gaggccgcac cgatgcgcga
    21661 ggtcgcctgg cgaaataccg atccggtggg agaggcgcag gaggtagccc ggcaggagtt
    21721 cgccgggtgc cgggtccagg cttctgggca acggcgtgtt catgctgtgt ccgcggcggg
    21781 gccgaggtca tcgaagacgg tgttgcggcg tcggctggtg ggcggtcggc ggccggaccg
    21841 tgcggggacg gcagggatct cccctgcttc ggcatcgcgg ccggttcctg ccagggtcag
    21901 ggggagagca tcgaaaaggg gtcgggtcag gcgttcggag ccgctggcga tggcctgcga
    21961 gcagccgtcc tcgatcaggc gctccagcag gcccacgacg ccgttggtcc gctcgtagag
    22021 gtactcgggc atggtgttgt cggtgagcat gccggggcgc gccttgagca ggcgcaggtg
    22081 atgctcgatg ccggcgaggt gggaggtcca agcggtgatc tgctcggctg tgtcgtagcg
    22141 gaaccggtcg agttcaacaa ggtcgaagcg gcgctcggtc tgggtgggct cccacccgtt
    22201 cgcactcttg gcagccgccg gtccgcggcc ttcacgcaag aggccggagc cggggatgcc
    22261 caccccgacc aggacgagag tgacgtgcat gctcatgaaa gcgcggatta ggtccagggt
    22321 gtcttggtcg tcggcgcggt gcatgcgcag ccgggtgatg tcatcgagga ttagcacctt
    22381 cgtgccatgg tccgacaggg aggcggcgac ctggtggatc agctcgggca ggtccatccg
    22441 cttggtcggg gctccgtaga agtcgaggat cgccttgcag gtacttttcg gtttcgccgt
    22501 cacgggcgtc tgcacgtagg cgactggcgc ccataggtcg cggctgccgg gcaccgtctc
    22561 ggggttggtg cggtgcaggt cgcgccagga gtcctcgaaa gcggcggcga tctcgcacac
    22621 ggtctcggtc ttgccctggt agccgcctcc agacaccatc acccccgccc tggtggctgg
    22681 gcgggcctta aacgcgttct gtcggatccg cgcagccagg agccggccca cagcctggct
    22741 catcggtgtc cccaacaggg gcaggttcgc gtgcgttgcc gcccgggcca gatcccaagc
    22801 ggccttctcc gctgccggca tcgtcctcca gcgcgccggg gagatgcgag gcgcgggctc
    22861 gaaggagtgt ctgctcagcc gccacacctc ccatccggcc agcgcgtccc gtcgcaagtc
    22921 gccggtcatg ccgtaccgcc gtcatgcttg atcgattcgg cgcgatcgct gtctggccgt
    22981 tccagcttgt ccaggtccgc gtggggctcc ggtctggctg tcgggtagag cgtgcgggcg
    23041 gccaggccgt caccgagccg ggctgcggga accggccggg ccccgcccgt tgcggcccgt
    23101 cggcgtcgca gccggtcggt cgtgatcgcg tcctcgacct cccgcctcgg cgcagactgt
    23161 gcggcgggtg ccgtcggcgg ccggtcgtcg gggcggtccg ccgtggccgc acgggcgcga
    23221 gcgagctcgc gggcccgggc ggcggcccgc tttctggcct ccgggcggcc gggccagccc
    23281 tcgaccggag tgacctcggc caacaggtcg agcagtacgg gcagcagctc ggtgtctgtg
    23341 cgggggcgaa gcccggaccg ggcggcttcc ttgaggacct cgccgacccg ggcatccccg
    23401 aaggcgggca ccgtcccctc gggcggcagg ccgttccacg gcaagggatg ccaggtgccg
    23461 tctagttcga tgaacacctg gcggcagtcc ctcgggtcgc ggcgtactgc ccactttccg
    23521 gcatgccgcc caccgcgcgg tgccgggaca ccgcggcacg ggtcgagggc cgggctgtgg
    23581 gccccgtacc agaggccgcc aaccttcact ccacgccggg cgtcgatctt cacgaagtgc
    23641 accggcagca gctcgtagta cagctcgggc gccgggatct ccaaggcgat gccgtcgcgg
    23701 gctgctgcgg cggcgaagag ggtgttcggg ctgtgccggc ccgaggggtc ccaggccgga
    23761 gcgtgctggt ccaggcgccg gttttgccac acggagacga tccacgaggc gagcaggtgc
    23821 tccatctctg ccaccgtcca cgccgcgtcc gcttccgggt cggcgccgcg gtcggcgacg
    23881 tcgatgccgc gccaaccggg taggagttcc aggagcaggg actggatcgc ggcgaaagcc
    23941 cgctcgcagg cggctttgtc tgtcggccgc atcgcccggg ccggcagcac gtccacgccg
    24001 agcgtgcggg ctacttggac caggtggtga ttcttgaacg cggacccgtg gtcgacggtg
    24061 atcgcctccg gggtgaagaa cggcagcccg gccaccggcc cgcccgccaa gtcggccacc
    24121 agcgcggctg ggacccccgg atacggccag gccatggtcg cgccccagcc cggacgcatg
    24181 ggcagcggcg agagcacatc ccgcagcagc atcgccacct cgatcgacga ctccgccacc
    24241 ggcgtcagcc ggaacgcgac gatcgagtgc gtgtaggcgt ccagcgcgat cgtcaggtgc
    24301 acggtgatcg gggtgccgaa gacgtcgtcg aggaccttca ccggcaaagg cgtcgagtcc
    24361 agcaccacca cctgccccgg ccgcgacgcg atcaccggta ccccggccgg tgcggggacc
    24421 gcggcggccg agcgtacgta ccgctggcgg gacccgccgg gcccgaacca ctcccgccac
    24481 acccgcgcca gcgtcgtgcg gtgcggcacc cgcacctgcc ggtccgggaa aacctcccgc
    24541 acgtactggt ggatcaaccg ctcccgcgag gccatgctga tccgcgacct gcgcaggcac
    24601 tgctcatgca ccgcccggat cgcctcctcc acatcggccg tcaccgatgg gtggccgccg
    24661 gcctgccgcg tccaccggcc gtcggccagc ccaatgaggc cggactcgcg gtagcgggcg
    24721 gccatccgct tcagggtgcg ttcgctgact gactccagcc cgagtcgggc ggcctcggtc
    24781 tccggcagcg cgccgagctc ggcaaccttg gccaagcggc gctctccgag gttggtggtc
    24841 gcagggtcga aggctggccg gggctcatct ggtcgggccc agtgacggct gccactgcgg
    24901 aatccggtct cgacctccat gaggtgctct agccggatgc gaaggcgagc cagatcctgc
    24961 tcggtgagct cctcgaccaa cggcgtgcgg tcacccgcgt cggccatcat ggccccacag
    25021 ggtagatcca ggtgccatcc ccgagcggcc cgttcaggtc gaaggccaag cgccgcttcc
    25081 acagcagccg ttgcaggtga tcccgcgcca gtaccggcca cgacgtcgcg gcgacgagct
    25141 cgccgaatcg acggggcctg accgctgccc cgaggagctg atcttccagg cccagcgggt
    25201 cggtgtgccg gcgacgcccg cgtgccaggg cctccacggt gtccgcgacg ttgtttcgcc
    25261 agccagtcac caccaggtac cgccagccag cggaagccgc cacccggccg gtcgccgcga
    25321 acacggtcac atccgactcc ttcacaaggt gtgccggacg gacatcaatc aacagcgtcg
    25381 cccccgccgt ggccaccagg aagtccggga tgtgtgtgcg gcgggccccg tcgaggaacc
    25441 gcaggcggaa cggctgcgag agcacatcgc ggacctggcc gcagaagtcc aaaacggtca
    25501 gcgcgcgtcg ctcggccagg ctctcgaagc cgtgtccgcg gcccgtcgcc cccataaacg
    25561 ccagcccggg cctgtgccgc tgccccgggc gccaggagaa cgcgcgaaca ggctgggccc
    25621 gagtccaggg gaaggtggcc agatctcgca cgggacagac gatgtcgctt ccgtcgacct
    25681 gccacgtcac cgtccagcga gcggtccaat cgcggcgtgg atcgagggcc tccccgcaca
    25741 tcaccgcgta cggcacgacc aactcatcga acccacagca gtgcgaccac acggccctct
    25801 ggtcagtacc cgtcatgcca ccagcacacc gcgcggaaca tgccgaaatc cgcagaacgc
    25861 agaaacagcc gtgatcagga tgatccaccc actaccctgc gggccaccta tcacgctcag
    25921 aggccaacta gcgtgctcaa gggccatcta tcgtgctcag tctcaagtag caggtcacga
    25981 gggaaggggg aggcgccgta cacccattag ccatttgttc gattcttgcg gcaagcacga
    26041 ctacccgacc gtggcacttc gagagcgtca gtgtcctgtg gcatcgaacc ttgagcgcgt
    26101 gccaacgcac cttgacggac gcggcctagt gacaaggttg attgcgctga ccagagccca
    26161 gatgcggccc ggcgcccgag agcgcacctt gcggctccgc cgcatgggca tcggcggtgc
    26221 ccgtgccggg gctacagcga acgctggggg tggagcgagc cgttggcagt ggcagtcgct
    26281 tcagcggccg gcggtcgcgg caggttcgcg ggcggacgtg tcgtgcagtc cgaggcgtag
    26341 gtgttcaacg tggtagaggg cctggtcgag gagttctgcg acgtggttgt cgtagaggga
    26401 gtagacgatg ctgcggccct ggcgttcgcc ggtgaccagg ccgaggttgc gcagcaggcg
    26461 gagctggtgg gagcaggcgg agttctccat gccgacggct tcggcgaggt cgctcaccga
    26521 gcaggggcct tcctgaaggc gggtgaggat gtagagccgg gagggtgtgg ccagggcctg
    26581 gagggtggcg gcgacgtcgg cggcgccgac agcgtcgagg cgctcgcggg tgctagcgct
    26641 gatggtggtg tcgcgtccgt ggcccatgag cccatcatac cgacgacagt tgaagacctg
    26701 ttcaggtatt cctgtacggt gggatcgttg ccgtcgcccc gcccgtgaag ggttgctttg
    26761 tcatgtcttc tgcccttgat caacggtccg cgccgcccgc cggagccgcg cgcccggcgg
    26821 ctccgcgccg ccgcacccgc ctgctggcac tgcccgaggc acgctgggcg ctcgcgtctc
    26881 tggtgctgtt cctccttgct ctgcccgtct acctgctgga cggtccggcg tggctgtggg
    26941 gcacgctgtt cgccaccacc tacataaccg gtggctggga gccgggccgg gagggcctga
    27001 aggcgctgaa ggacaagacg ctggacgtgg acctgctgat ggtcgtcgcc gccctcgggg
    27061 cggcctcgat cgggcaggtc ctggacggtg cgctgctgat cgtcatcttc gccacctccg
    27121 gcgctctgga ggccgtggcc accgcccgga ccgcggattc cgtgcgggga ctgctcgacc
    27181 tcgcgccgac cacggcgacc cgtctgctgc ccgatggctc ggaggagagc gtcgatgcgc
    27241 agtcgctggc catcggggac acggtcctgg tgcgtcccgg tgagcgggtc ggcgccgacg
    27301 gccaggtggt cgacgggacg agcgatgtcg accaggccac catcaccggt gagccgctgc
    27361 cggtggccaa gcgggccggg gacgaggtgt tcgccggtac ggtcaacggc accggcgccc
    27421 tgcgtgtgcg ggtcgagcgc gacccgtcgg actcggtgat cgcccggatc gtgaagatgg
    27481 tcgaggaagc ctccgagacc aaggccccca cccagctgtt catcgagaag atcgagcagc
    27541 ggtactcgct cggcatggtg atcgccaccc tcgccgtctt cggtatcccg ctcgcgttcg
    27601 gtgacgccct ccagtcggcc ctgctgcggg cgatgacgtt catgatcgtg gcctcaccct
    27661 gtgcggtggt gctctccacc atgccgccgc tgctggccgc catcgccaac gccggacggc
    27721 gtggtgtgct ggccaagtcc gccgtcgtca tggaacgcct cggccagatc gatctggtgg
    27781 ccctggacaa gaccggcacc ctcaccgaag gcaccccccg cgtcaccgac atccgccccc
    27841 tgcccgacgc cggcctggac gaggacggcc tacttactct ggcggcagcg gccgagcatt
    27901 ccagcgaaca cccgctcgcc cgcgccgtcg tcgacgccgc ccgccaacgc ggccttcacc
    27961 tgcccgaggc cgccgacttc tcctccacac ccggtgaagg cgtcaccgcc accgtcgagg
    28021 gccgcaccgt ccaggtcggc tccccctccc ggctgctcac cgccacgtcg tcgcacgaca
    28081 aggtcgtggc cgagatggag gacgtcggcc gcaccgcggt ggcggtcctg cgggacggca
    28141 cggtcgtagg cgtcctcggc gtcgccgacc ggctccggcc cgacgccgcc gcgacggtgg
    28201 ccgccctcac caggctgact ggccgtaccc ccgtcctgct caccggcgac aacgaacgcg
    28261 ccgcccggca cctggccgcc caggtcggca tcaccgacgt ccgcgccaga ctcctccctc
    28321 aggacaaggt cgcagccgtc aaggagtggg aggcggaagg gcgccgagtg ctggtggtcg
    28381 gcgacggcgt c
//
