LOCUS       NZ_KZ679082            22214 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Streptomyces sp. CS149 scaffold00001, whole genome shotgun sequence.
ACCESSION   NZ_KZ679082
VERSION     NZ_KZ679082.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. CS149
  ORGANISM  Streptomyces sp. CS149
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7754255)
  AUTHORS   Malmierca,M.G., Perez-Victoria,I., Martin,J., Reyes,F., Mendez,C.,
            Olano,C. and Salas,J.A.
  TITLE     Cooperative Involvement of Glycosyltransferases in the Transfer of
            Amino Sugars during the Biosynthesis of the Macrolactam Sipanmycin
            by Streptomyces sp. Strain CS149
  JOURNAL   Appl Environ Microbiol 84 (18), e01462-18 (2018)
   PUBMED   30006405
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7754255)
  AUTHORS   Olano,C., Malmierca,M.G., Mendez,C. and Salas,J.A.
  TITLE     Characterization of the biosynthesis gene cluster for the
            macrolactam sipanmycins: involvement of four glycosyltransferases in
            the transfer of two aminosugars
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 7754255)
  AUTHORS   Olano,C., Malmierca,M.G., Mendez,C. and Salas,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2018) Biologia Funcional, Area de Microbiologia,
            Universidad de Oviedo, Julian Claveria S/N, Oviedo, Asturias 33006,
            Spain
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 556.87x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 11:43:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,915
            CDSs (total)                      :: 6,834
            Genes (coding)                    :: 6,691
            CDSs (with protein)               :: 6,691
            Genes (RNA)                       :: 81
            rRNAs                             :: 12, 7 (16S, 23S)
            complete rRNAs                    :: 12, 7 (16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 143
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 52 of 144
            Pseudo Genes (incomplete)         :: 108 of 144
            Pseudo Genes (internal stop)      :: 12 of 144
            Pseudo Genes (multiple problems)  :: 27 of 144
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:40:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 85338
            Orig. end                         :: 107552
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ679082.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Professor JA Salas
            laboratory.
FEATURES             Location/Qualifiers
     region          1..22214
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22214
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22214
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12214](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12214
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(201..210)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(283..1074)
                     /locus_tag="C6W96_RS00420"
                     /old_locus_tag="C6W96_00415"
     CDS             complement(283..1074)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019766343.1"
                     /locus_tag="C6W96_RS00420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00415"
                     /product="DUF4389 domain-containing protein"
                     /protein_id="WP_107409733.1"
                     /transl_table=11
                     /translation="MAEGQWSPGRKEADADEFRPVLDIVEPARQRRLTVLLRLLLLVPH
                     FIVLFFLHIAAFFTVIVGWFAALVLGRLPDPVFRFLTGVLGYDMRVSASDMLLIDRYPP
                     FALTPSADYPVQIEVRPTPLNRLAVLFRIFLMIPAAIVQSLAVYGWWALAFVWWLITLC
                     LGRMPRPLFEATAATLRYRMRFSAYVMMLTPAYPKALFGDDGLAVLPEQARSATRPLVL
                     SSAAKWLVVLFLVLGLAGHITSSLTASTTDDTTDTQLVGTP"
     gene            complement(1189..1806)
                     /locus_tag="C6W96_RS00425"
                     /old_locus_tag="C6W96_00420"
     CDS             complement(1189..1806)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382265.1"
                     /locus_tag="C6W96_RS00425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00420"
                     /product="VanZ family protein"
                     /protein_id="WP_107409734.1"
                     /transl_table=11
                     /translation="MTAEANPPARQGTWVRVLVRGAVLTVVLLGLVAFSVLLAKVTLTP
                     SPASEDLVTANLRPGRSLRQYAEDYTFLAACKQAGGNLLLGVPFGLLLPFFVPRRLRMI
                     RTTLLTAVAMAVVELVQGALVQGRAFDIDDVILNTAGALLGYFVLGRRISHRYYMYADV
                     PGSSEPRDEPKPQPARTPEKAAAKKTTASKAPRPLLDRLRRR"
     gene            1904..2404
                     /locus_tag="C6W96_RS00430"
                     /old_locus_tag="C6W96_00425"
     CDS             1904..2404
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971171.1"
                     /locus_tag="C6W96_RS00430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00425"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_107409735.1"
                     /transl_table=11
                     /translation="MSAEKKKDLLDEADRLREGGRPEEARERLLALTAEYPDDAEVACR
                     TAWIHDALGLESEAVPYYERALANPGLSAEDRRGSLLGLGSTYRVLGRYGQGVETLRRG
                     VEEFPDDGAMRTFLAMALFNTGEHDEAMRLLLELTAATSQDPYVQQYRRAIEHYAKDLH
                     ETV"
     gene            2494..3252
                     /locus_tag="C6W96_RS00435"
                     /old_locus_tag="C6W96_00430"
     CDS             2494..3252
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060704.1"
                     /locus_tag="C6W96_RS00435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00430"
                     /product="YoaK family protein"
                     /protein_id="WP_234389165.1"
                     /transl_table=11
                     /translation="MYSAPPALPPSPPSASSSGASLTGDAPWRGEAALFLLSAASGAAD
                     AFVFLCVGQVFAGVMTGNLVLLGASAAGAGEDGVALKVAVALGAYFCGVAAGALMAGRR
                     GYRVPVLLGVEVVLLGAAAVLWGPGLVTSYGERLGLLALVAVAMGVQGRVRVTPTNYFT
                     GTLTSLAGRVALRELRAGDGWVLGRLAAVVAGAAVAALAERWWSPGAALGAVVMAAGAL
                     ALETVPGRGGRFRRDKGKPRPDRGNPAGAA"
     gene            complement(3477..3737)
                     /locus_tag="C6W96_RS00440"
                     /old_locus_tag="C6W96_00435"
     CDS             complement(3477..3737)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956431.1"
                     /locus_tag="C6W96_RS00440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00435"
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="WP_107409736.1"
                     /transl_table=11
                     /translation="MKSRIHPVSRPVVFRDRAADVAFLTRSTADSGERVVWEDGNSYPV
                     IDVETSSASHPFYTGGTRVLDTAGRVERFHRRYGAGQASGS"
     gene            complement(3801..3965)
                     /gene="rpmG"
                     /locus_tag="C6W96_RS00445"
                     /old_locus_tag="C6W96_00440"
     CDS             complement(3801..3965)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010470368.1"
                     /locus_tag="C6W96_RS00445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00440"
                     /product="50S ribosomal protein L33"
                     /protein_id="WP_032768867.1"
                     /transl_table=11
                     /translation="MARSESRPVVTLRSTAGTGRSYATRKNRRNHPDRLELRKFDSAVG
                     RHVLFREVR"
     misc_feature    4010..4025
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    4012..4026
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.29"
                     /tool="antismash"
     misc_feature    complement(4014..4025)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.7"
                     /tool="antismash"
     misc_feature    4151..4166
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.28"
                     /tool="antismash"
     gene            4321..5751
                     /locus_tag="C6W96_RS00450"
                     /old_locus_tag="C6W96_00445"
     CDS             4321..5751
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956434.1"
                     /locus_tag="C6W96_RS00450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00445"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_107409737.1"
                     /transl_table=11
                     /translation="MPSPLFADRPAPQLPAHDAVDDLIHRTRRLRGDVDAVRRDAAMFD
                     EDDPQLRWQRALCELAVHHLDTLGEHLGQLRAGLPGPSGEDSASEDEEAPDGPRAGSLL
                     SRVGSAEWNLLTDESSWSEELYEIFGRPLDSAPLSLDDLPSVLLPEDQPVLTAMVTGCL
                     VDGRPMDGEFRIVRPDGGTRTLHMTGEPVLDGEGCTASMWAVLRDVSELRRSEQAVTRS
                     RASVQREEHIERTEHRMAVELQETVLPPWRGSLRLPPQGPGALDIAAHYLPSASSGLIG
                     GDWYDAMELPDGRTLLTVGDLTGHGIPATSAMAMLLGALRGMAVAGIEPGALMGHLNRV
                     LETSIQPALGSALCCRFDPGTSVLSWAQAGHPAPLLFRGGSGRVLPPPDGILLGAAPQA
                     VFEQDEVRLFPGDVLVLHTDGLTRRGDRGAGPEALLALAPRFADARTAQECVRGVVEEF
                     GGTERLDDACVLVARIGA"
     gene            complement(5837..7324)
                     /locus_tag="C6W96_RS00455"
                     /old_locus_tag="C6W96_00450"
     CDS             complement(5837..7324)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458453.1"
                     /locus_tag="C6W96_RS00455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00450"
                     /product="hypothetical protein"
                     /protein_id="WP_107409738.1"
                     /transl_table=11
                     /translation="MTGEPNTRLSDLFGLAGWSKGELARMVNRQAAAMGHPQLATDTSR
                     VRRWIDMGESPRDPVPEVLAALFTERLGRVVTIEDLGFGRRGRVGKRRDSGTEHNPDQL
                     PWAPERTAAVLTEFTGMDLMLNRRGLVGAGAALAAGSTIAGPMYDWLHSDPAPAADAPR
                     TNAPLHADPAGLDRYEAAPVGSDEIAALEHSVEVFRAWDASRGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPDDALDLMKLAKSGSGDETLPRTQAMLRTIEAWAQASMGRGQA
                     MRRTLGEAEELFVSDKSDVPPPSWMQMFDEADMHGMQALAFRTLAEHDPGAAVIAQRHA
                     KQALELRVNGRQRSKIFDYISLASACFIANDPEQADRYARLALVSMGETSSHRTWDRLR
                     EMYRLTGQFAGYAGIQDLREEIELSMPSQKKARGTQI"
     gene            7556..8692
                     /locus_tag="C6W96_RS00460"
                     /old_locus_tag="C6W96_00455"
     CDS             7556..8692
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="C6W96_RS00460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00455"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_032778123.1"
                     /sec_met_domain="APH (E-value: 3.1e-17, bitscore: 61.9,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSAPPRPLRPMGAGGGPYLAPHAGAPVQGPGRARRAAG
                     PGAGPLSGRIDLSGPQGAQVRMAIASVQRICPEFNPVQVLRRSGRSVLIVGTTGRATAV
                     AKCLLDHSPAWTERFRHEIAAYRAFVRHRPPVRVPRLIAADPENCTLVIERMPGRVAAL
                     TRHPAEAPPRADIRAALGAIARVNAWRPPPGLFEAPLDYASRIARYHELGLFTDRDLGD
                     LQKLLHGLAHAGGRQGMGQFCHGDALLSNILLSPTGPVLVDWEHAGWYLPGYDLATLWA
                     VLGDAPVARRQISQLAQARGPAARDAFLVNLMLVLTREIRNYETAVQRTMREAPAVGAG
                     ADRPGALSSGEEQRLLLRRLHDDCAMARRAVRAAVGTR"
     misc_feature    7877..7879
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9185..9838
                     /locus_tag="C6W96_RS00465"
                     /old_locus_tag="C6W96_00460"
     CDS             9185..9838
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971163.1"
                     /locus_tag="C6W96_RS00465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00460"
                     /product="transglycosylase SLT domain-containing protein"
                     /protein_id="WP_107409739.1"
                     /transl_table=11
                     /translation="MPRISTLRITRSHKIATAVLVAAGSVTAITATGGPSEAQTTATQS
                     SVSVEPVAAAGIPTAKDAAEKAAKENAAKEAAAKKATAKALAEKERSEKQAANRSTERK
                     AVTPKKYANNLDGWIRESLDIMEKKNIPGSYEGLHRNIMRESSGNPNAVNDWDINARNG
                     IPSKGLLQVIQPTFDAYHVKGTPKNLTDPVANITAAANYAADRYGSIDNVDSAY"
     misc_feature    9888..9903
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.35"
                     /tool="antismash"
     misc_feature    complement(9891..9906)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.21"
                     /tool="antismash"
     gene            10001..12214
                     /locus_tag="C6W96_RS00470"
                     /old_locus_tag="C6W96_00465"
     CDS             10001..12214
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606689.1"
                     /locus_tag="C6W96_RS00470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00465"
                     /product="terpene synthase family protein"
                     /protein_id="WP_107409740.1"
                     /sec_met_domain="T1TS (E-value: 1.2e-84, bitscore: 283.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFSLPDFYVPYPARLNPHVEAARSHTREWARSMGMLEGSGIW
                     EEKDLEAHDYALLCAYTHPDCSAEALSLVTDWYVWVFFFDDHFLELFKRTPDRAGGKRY
                     LDRLPAFMPMERGAATPEPENPVEAGLADLWARTVPAMTDDWRARFAESTENLLNESLW
                     ELANIHEGRIANPVEYIEMRRKVGGAPWSAGLVEYAADAEVPASVAGSRPLRVLRDAFS
                     DAVHLRNDLFSYQREVEDEGENSNGVLVLEKFLGCSTQEAADAVNDLLTSRLQQFENTA
                     LTELGPLCAEKALDPAQTAAVLAYAKGLQDWQSGGHEWHMRSSRYMNGGGAGEAVAGWG
                     MSAASIRFTLRSETARSRSHSHVPYQHVGPSLLPDFDLPFGTTLSPHLEGARVRLVEWA
                     RRMGILEAQPGVPGSHIWDERRIVAIDLPLCAAGLHPDATPDELDLSSGWLAWGTYGDD
                     WFPVVHGRARDLAGARLANERLSLFMPLDGEGTPEPVNALERSLGDLWRRTAAPMDQGA
                     RRTFRTSIESMTESWLWELANQAQNRIPDPVDYVEMRRATFGSDLTMSLCRLGHGRTVP
                     EEVYRSGPMRSLENAAADYACLMNDLFSYQKEIEYEGEVHNGVLVVQNFFGVDYPTGVA
                     IVHDLMNSRLRQFLHVAEVELPVLYDDFGLDAEAREVLAGYVQELKHWIAGILIWHRGC
                     RRYREEDLRQGNDTPWHLGGPTGIGTSAAQVTRMMAQLAGSRG"
     gene            complement(12306..12863)
                     /locus_tag="C6W96_RS00475"
                     /old_locus_tag="C6W96_00470"
     CDS             complement(12306..12863)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060717.1"
                     /locus_tag="C6W96_RS00475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00470"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_107409741.1"
                     /transl_table=11
                     /translation="MTPSPTDGRLLKGELRRQELIEATLRVVAREGVAGVSHRAVAREA
                     NQPATAAAYYFKSIDDLLTAALTVCMDQDAERMRRLAESADGGPEGLTALAELLGHVMK
                     GPGRLLAEYELYLLAARRPELRTSTGRWLDAIAGYALRYTDDPVRVQILKGVIDGLLLQ
                     GLLTDTPPTAAEFEAVLRHVLL"
     gene            complement(12860..14170)
                     /locus_tag="C6W96_RS00480"
                     /old_locus_tag="C6W96_00475"
     CDS             complement(12860..14170)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946565.1"
                     /locus_tag="C6W96_RS00480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00475"
                     /product="MFS transporter"
                     /protein_id="WP_107409742.1"
                     /transl_table=11
                     /translation="MANPYGALFRAPGSLAFSAAGFVARMPLSMTGIGIITMLSQMRGQ
                     YGLAGAVSATFTLSMALCGPQISRVVDRRGQSRVLLPATGLSVIAMGVLLLCARYGAPV
                     WTLFVSAAAAGTMPNMAAMVRARWTHLHRGSDRLHTAYSLESVVDELTFVVGPALAVAL
                     STALFPEAGPLVAAVLLALGVLMFVPQKRTEPPVLRPAADGAPRVSALRGGPLVLLALT
                     LVAGGTIVGTVDVVSVAFAEAQGSPAGAGIVLSVYAIGSAGAGLVFGALRLGVPLPRLL
                     LLSTAGTALTTLPLLLVENIATLSAAVFFSGLFFAPTMIVVMGLVEKTVEPAALTEGMT
                     WAITGLSVGVALGASVSGGMVDRFGPSGGFTVALAAGGATVLLALTAQGPLDRSLRARA
                     EAPADEGDAKPVPRTPRGHEERHPASVPLDHDARRAR"
     gene            complement(14360..14860)
                     /locus_tag="C6W96_RS00485"
                     /old_locus_tag="C6W96_00480"
     CDS             complement(14360..14860)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="C6W96_RS00485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00480"
                     /product="hypothetical protein"
                     /protein_id="WP_003971159.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLYGGRGPAMIIGNLPEGSPARETEEGQVPFEVAQLLLALENDEPIEVVSSEDV
                     PVMQGDNLLIVRRVKLSESRIACVQFDRSDGVLVTIASWDRPITDDLYTLLKPLPAELF
                     QQG"
     misc_feature    14864..14874
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            complement(14985..16151)
                     /locus_tag="C6W96_RS00490"
                     /old_locus_tag="C6W96_00485"
     CDS             complement(14985..16151)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971158.1"
                     /locus_tag="C6W96_RS00490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00485"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_107409743.1"
                     /transl_table=11
                     /translation="MSKEPVAVVGIGQTKHVAARHDVSIAGLVREAAVRALEDAGLGWA
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAANLVAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYMRRTGAPDTVGS
                     LVAYKDRRNALKNPYAHIHDHDLTLEKVQSSPMLWDPVRYSETCPSSDGACAMILTGRD
                     GAARSPHPPAWVHGGAMRSEPTLFAGKDFVSPQAGRECAADVYRQARITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFADEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGRAGEHQIDGATRALGHAYGGGSQFFAMWLVGAEPPPG"
     gene            complement(16144..17196)
                     /locus_tag="C6W96_RS00495"
                     /old_locus_tag="C6W96_00490"
     CDS             complement(16144..17196)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060725.1"
                     /locus_tag="C6W96_RS00495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00490"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_107409744.1"
                     /transl_table=11
                     /translation="MRDVAIVAFAQSAHRRRTDELSEVDLLMPVLHEVLGATGLKANEI
                     GFTCSGSADYLAGRAFSFTMALDGVGAHPPISESHVEMDGAWALYEAWVKLRTGEADTA
                     LVYSYGKSSPGRVRDVLTRQLDPYYLAPLWPDSVALAALQAQALIDAGDTDEGALAQIA
                     ARNRTAAVDNPYAQLTGDVPAGDHLVHPLRTGDCPPIGDGAAAVVLAAGDTARALCERA
                     AWIRGIDHRIEAHSLGVRDLTDSPSARLAAEHAGAFERPVDTAELHAPFTSQEVVLRKA
                     LGLGDEVSVNPSGGALAANPVMAAGLIRLGEAAARIHRGESDRALAHATSGPCLQQNLV
                     AVLEGESAHE"
     gene            complement(17197..18153)
                     /locus_tag="C6W96_RS00500"
                     /old_locus_tag="C6W96_00495"
     CDS             complement(17197..18153)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382254.1"
                     /locus_tag="C6W96_RS00500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00495"
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_107409745.1"
                     /transl_table=11
                     /translation="MPDVLSAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRTDDGTV
                     LVPPVEYDPVSANELGDLVEVAPTGTVTTWAWNPSPRRDQPLDTPFAWVLVRLDGAGTA
                     LLHVLDAPGPDAVRTGMRVRIRWAATRTGAITDIACFEPYEGEPGPTEPAPHTGEFADP
                     VTGIVAPARLDYLHTPGRAQSAYIKALEERRTVGERCPACRKVYVPPRGACPTCGVATA
                     EQVEVGPCGTVTTFCIVNIKAKNLDIEVPYVYAHIALDGADLPLHGRIAGIPYDQVRMG
                     LRVEPVWTGAGRGSRHVDHYRPTGEPDADYDTYKELV"
     gene            complement(18169..18969)
                     /locus_tag="C6W96_RS00505"
                     /old_locus_tag="C6W96_00500"
     CDS             complement(18169..18969)
                     /NRPS_PKS="Domain: ECH (9-258). E-value: 4.3e-53. Score:
                     172.1. Matches aSDomain:
                     nrpspksdomains_C6W96_RS00505_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956444.1"
                     /locus_tag="C6W96_RS00505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00500"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_107409746.1"
                     /transl_table=11
                     /translation="MGGTEHLTVRREGATLVLTLNRPQARNALSLPMLVGLYDGWLAAD
                     ADDTVRSVVLTGAGGAFCSGMDLKALAGDGMAGEEYRERMTADPDLHWKAMLRHHRPRK
                     PVIAAVEGPCVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTH
                     ALEMLLTGRPYTADEAAAIGLIGRVVPDGAALEEALAVAERVNACGPLAVEAVKASVYE
                     GAELTESEALAAELKRGWPVFATEDAKEGARAFAEKRPPVYRRA"
     aSDomain        complement(18196..18942)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6W96_RS00505_ECH.1"
                     /evalue="4.30E-53"
                     /label="C6W96_RS00505_ECH.1"
                     /locus_tag="C6W96_RS00505"
                     /protein_end="258"
                     /protein_start="9"
                     /score="172.1"
                     /tool="antismash"
                     /translation="RREGATLVLTLNRPQARNALSLPMLVGLYDGWLAADADDTVRSVV
                     LTGAGGAFCSGMDLKALAGDGMAGEEYRERMTADPDLHWKAMLRHHRPRKPVIAAVEGP
                     CVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTHALEMLLTGR
                     PYTADEAAAIGLIGRVVPDGAALEEALAVAERVNACGPLAVEAVKASVYEGAELTESEA
                     LAAELKRGWPVFATEDAKEGARAFAEK"
     misc_feature    19024..19039
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    19025..19041
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    19029..19043
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.75"
                     /tool="antismash"
     gene            19137..20762
                     /locus_tag="C6W96_RS00510"
                     /old_locus_tag="C6W96_00505"
     CDS             19137..20762
                     /NRPS_PKS="Domain: AMP-binding (8-439). E-value: 7.5e-67.
                     Score: 217.6. Matches aSDomain:
                     nrpspksdomains_C6W96_RS00510_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382252.1"
                     /locus_tag="C6W96_RS00510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6W96_00505"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_107409747.1"
                     /sec_met_domain="AMP-binding (E-value: 2.6e-69, bitscore:
                     232.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVVDAVPDREALLYVDHPGTGAERRLTYAELDAAA
                     NRIAHHLIDAGIRPGEHLGLHLYNGVEYLQTVLGALKARIVPVNVNYRYVEEELVYLYR
                     DADLAALVFDGEFDERVAAAAPQAPGLRHLVRVGPSATTAAPGPVAVPFTEAEASGSPD
                     RGFTPRSADDQFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKTPQELAERVA
                     AGGDGITFFPTPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPEEVLRTIEKEKVTSVSLV
                     GDAMLRPLIDCLKGALRGTDCSSLFSVSSSGAIMSDSVRAEFQELVPTVMLLNNFGSSE
                     SGFNGTATADSGPEKGFRVQVNARTAVVDPVTYEPVAPGEPGRIAQRGHVPLGYYNDPA
                     KTADTFFRRGDERWVLLGDMATVDADGIVTVLGRGSQCINTGGEKVYPEEVEQALKSHA
                     DVYDALVAGVPDERWGNRVAAVVQLREGVAALTLEAVQAHCRTRLAGYKIPRALVLADR
                     IQRSPSGKADYRWAKAVAAEAHRS"
     aSDomain        19161..20453
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6W96_RS00510_AMP-binding.1"
                     /evalue="7.50E-67"
                     /label="C6W96_RS00510_AMP-binding.1"
                     /locus_tag="C6W96_RS00510"
                     /protein_end="439"
                     /protein_start="8"
                     /score="217.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDAVPDREALLYVDHPGTGAERRLTYAELDAAANRIAHHLI
                     DAGIRPGEHLGLHLYNGVEYLQTVLGALKARIVPVNVNYRYVEEELVYLYRDADLAALV
                     FDGEFDERVAAAAPQAPGLRHLVRVGPSATTAAPGPVAVPFTEAEASGSPDRGFTPRSA
                     DDQFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKTPQELAERVAAGGDGITF
                     FPTPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPEEVLRTIEKEKVTSVSLVGDAMLRPL
                     IDCLKGALRGTDCSSLFSVSSSGAIMSDSVRAEFQELVPTVMLLNNFGSSESGFNGTAT
                     ADSGPEKGFRVQVNARTAVVDPVTYEPVAPGEPGRIAQRGHVPLGYYNDPAKTADTFFR
                     RGDERWVLLGDMATVDADGIVTVLGRGSQCIN"
     CDS_motif       19554..19589
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6W96_RS00510_0001"
                     /evalue="9.90E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="C6W96_RS00510"
                     /protein_end="151"
                     /protein_start="139"
                     /score="-3.3"
                     /tool="antismash"
                     /translation="SATTAAPGPVAV"
     CDS_motif       19659..19709
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6W96_RS00510_0002"
                     /evalue="3.10E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="C6W96_RS00510"
                     /protein_end="191"
                     /protein_start="174"
                     /score="19.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVMW"
     CDS_motif       20304..20351
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6W96_RS00510_0003"
                     /evalue="3.70E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="C6W96_RS00510"
                     /protein_end="405"
                     /protein_start="389"
                     /score="13.0"
                     /tool="antismash"
                     /translation="VPLGYYNDPAKTADTF"
     misc_feature    complement(21678..21692)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.2"
                     /tool="antismash"
     misc_feature    21679..21693
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.04"
                     /tool="antismash"
ORIGIN
        1 ggtgcgtggc cgtgccacgg cgaagtgatc ctcgacgcgc cggcctcggc ggtggcgggc
       61 cacatccacg acggaatcgt cgaggagcac ggccccgacc gctgccgggt ggtcctgggg
      121 gcctggtcgt ggcccggcct ggccgccggt ctcggcaggt tcgacgtgga catcgaggtc
      181 gtggggcccg acgagctcag ggccgccttc gccggtctgg cccgccgctt cgccgacgcg
      241 gcgggccggg gggcacgatg actccccggg gtccggtgcc ccttagggcg tgccgacgag
      301 ctgggtgtcg gtcgtgtcgt cggtcgtcga ggcggtcagg gacgaggtga tgtgtccggc
      361 gaggccgagc accaggaaga gcacgacgag ccacttcgcg gcgctgctca ggaccagggg
      421 gcgcgtcgcc gaccgcgcct gctccgggag gacggcgagg ccgtcgtcgc cgaacagcgc
      481 cttggggtag gcgggggtga gcatcatgac gtacgcggag aaacgcatcc ggtagcgcag
      541 ggtggccgcc gtcgcctcga acagcggccg gggcatccgg ccgaggcaga gcgtgatcag
      601 ccaccagacg aaggccagcg cccaccaccc gtacacggcg aggctctgca cgatcgccgc
      661 cgggatcatc agaaagatgc ggaagagcac cgcgagccgg ttgagcgggg tgggccgcac
      721 ctcgatctgc accgggtagt cggccgacgg ggtgagggcg aacggcgggt agcggtcgat
      781 gagcagcatg tcgctcgccg agacgcgcat gtcgtagccg aggacaccgg tcaggaagcg
      841 gaagacgggg tcgggcagcc gccccagcac cagggccgcg aaccatccca cgatgacggt
      901 gaagaacgcc gcgatgtgca ggaagaaaag cacgatgaag tgcgggacga gcagcaggag
      961 tcgcaggagt acggtcagcc gccgctggcg tgccggttcg acgatgtcca ggacgggccg
     1021 gaactcgtcg gcgtccgcct ccttgcggcc cgggctccac tggccttcgg ccatgtcgct
     1081 cctcctcggc aggggggatc cgggcgccat ccgcgcgcag gacgtgtccc caccgtgcgt
     1141 ccggtccggg ccgcccgcaa acggcccggc ccgaacgggt gcccgggctc agcgcctgcg
     1201 gaggcgatcg aggagggggc ggggggcctt cgacgcggtg gtctttttgg cagcggcctt
     1261 ctcaggagtg cgcgcgggct ggggcttggg ctcgtcccgc ggttcggagg agccggggac
     1321 gtcggcgtac atgtaatagc ggtggctgat gcggcggccc agcacgaagt acccgagcag
     1381 tgcgccggcc gtgttgagga tgacgtcgtc gatgtcgaag gcgcgtccct ggaccagggc
     1441 tccctggacc agctcgacga cggccatcgc gacggccgtc agcagcgtgg tccggatcat
     1501 ccgcaggcgt cgtggcacga agaacggcag caggagtccg aacggcacgc cgagcagcag
     1561 gtttccgccc gcttgcttgc acgcggcgag gaaggtgtag tcctcggcgt actggcgcag
     1621 cgagcgcccg gggcggaggt tggcggtgac gaggtcctcg gaggccggtg agggggtgag
     1681 cgtcaccttg gccagcagga cggagaacgc caccagtccc agcagcacca ccgtcaggac
     1741 cgccccgcgc accagtacac gtacccatgt cccctgccgc gcagggggat tcgcctctgc
     1801 tgtcatggcc gacggatgcc cccgccccgc cggaacacac accggagcgg gccgcggcgc
     1861 gaaatctcgt ccgccgtccg cgaccgcctg cgacgatgtg cgcatgagcg cagagaagaa
     1921 gaaggacctg ctggacgagg ccgaccggtt gcgtgagggg ggccggccgg aggaggcgcg
     1981 ggaacggctg ctcgccctga cggccgagta tccggacgac gccgaggtgg cctgccggac
     2041 ggcgtggatc cacgacgcgc tgggcctgga gtcggaggcg gtgccgtact acgagcgcgc
     2101 tctggccaac cccgggctct cggctgagga ccggcgcggg tcgctgctgg ggctgggcag
     2161 tacctaccgg gtcctcggcc ggtacgggca gggggtggag acgctgcgcc ggggcgtgga
     2221 ggagttcccg gacgacggtg cgatgcggac gttcctggcg atggcgctgt tcaacaccgg
     2281 cgagcacgac gaggcgatga ggctgttgct ggagctgacg gccgcgacca gccaggaccc
     2341 gtacgtccag cagtaccggc gggcgatcga gcactacgcg aaggacctcc acgagaccgt
     2401 gtgacccacg cggcggccgg ggcggtggta cgcggcgcgc cgcgcggcgg gcgacgcgcc
     2461 ggtcggggag cggcgcgtgc cgagaatgct cgggtgtact ccgctccccc ggcgctcccg
     2521 ccgtcccctc cttccgcctc ctcctccggc gcgtccctga ccggtgacgc accgtggcgc
     2581 ggcgaggcgg cgctgtttct gctgtccgcg gcttccgggg cggcggacgc gttcgtcttc
     2641 ctgtgcgtgg ggcaggtctt cgccggggtg atgaccggca acctggtgct gctcggggct
     2701 tcggccgccg gtgcgggcga ggacggcgtg gcgctgaagg tcgccgtcgc tctgggagcg
     2761 tacttctgcg gggtggcggc gggcgcgctg atggccgggc ggcgtggtta ccgggtcccg
     2821 gtgctgctcg gggtggaggt ggtcctgctg ggggcggccg ccgtgctgtg ggggccgggg
     2881 ctggtcacgt cgtacgggga acggctcggg ttgctggcac tggtggcggt ggcgatgggc
     2941 gtccaggggc gggtgcgggt gacgccgacg aactacttca ccgggacgct gacctcgctc
     3001 gccggccggg tggcgttgcg tgagctgcgc gccggggacg gctgggtgct ggggcggctg
     3061 gccgcggtgg tggcgggggc ggcggtcgcg gcgctggccg agcggtggtg gagccccggg
     3121 gccgcgctgg gggcggtggt gatggctgcc ggtgcgctgg ccctggagac ggttccgggg
     3181 cggggcggcc gcttccggcg ggacaagggg aagccccggc cggatcgggg gaatccagcc
     3241 ggggcggctt gagtgcgggc gtgaagggcg gtcgcctctc ggcggggggc tccatggggc
     3301 ttcggcggtg ccgatcgtcc ccatgggcta caggtgaggc ccggggacac tgtccccctc
     3361 acacccacgt atagatgaac gataaaccat cctggggtgt tcccgggaat ccgcccccgc
     3421 ggatgtgatc cacggcacgg acttcccggc ccttcccctg gtcaggctgc gttcggtcag
     3481 ctgccggacg cctggccggc gccgtagcgg cggtggaacc gctcgacgcg gcccgccgtg
     3541 tcgagcaccc gggtgccacc ggtgtagaac gggtggctcg ccgacgaggt ctccacgtcg
     3601 atgacggggt aggagttgcc gtcctcccac accacgcgct cgccggagtc ggcggtcgaa
     3661 cgggtcagga aggcgacgtc ggccgcacgg tcacggaaga cgacgggacg ggacacgggg
     3721 tggatacggg acttcatcga tgcgttcctt cctcaccgcg cgtggcggtg gcgtacggat
     3781 gccggaccac ttccgggcgg tcagcggacc tcgcggaaca ggacgtggcg gccgacggcg
     3841 gagtcgaact tgcggagctc cagccggtcg gggtgattgc ggcggttctt gcgtgtcgca
     3901 tagctgcggc ccgtcccggc ggtggaccgg agagtgacca cgggcctgga ttcactgcgc
     3961 gccacgggcg cctccttctc tgcctccgac gacccagccc cctatcggga atgggattcg
     4021 ttttcgttct ggtgaggtaa cgcgggtcga tcgcgtggca ttcccgcccg ccgcacaccc
     4081 gtcacctgcc acccgtgcgc ctctcccgca ccacccgttc accccgcgat gccacgtcaa
     4141 ctcacctcga acgcaagcct gttcggatat gcgcccaccc cggacagccg ctggcatatg
     4201 ccagaagcaa ccacgcatcg agtgttgcca aatcccctac ggcccgccgc ggcctgtgcg
     4261 acagtcggta gcggtccacc cttcagaacc ggctaggccg cgcctgcaac ggagtacgag
     4321 atgccgtccc ccctcttcgc ggaccgcccc gcaccacagc ttcccgcgca cgacgccgtc
     4381 gacgacctga tccaccggac gcgccggctg cgcggagatg tggacgccgt gcggcgggac
     4441 gccgccatgt tcgacgagga cgacccgcag ctgcgctggc agcgcgccct gtgcgagctg
     4501 gccgtgcacc acctggacac cctcggtgag cacctgggcc agctcagggc cggtctgccg
     4561 ggcccgagcg gcgaggactc cgcctccgag gacgaggagg cgccggacgg cccgagggcc
     4621 ggttccctgc tgagccgggt gggcagcgcc gagtggaacc tcctcaccga cgagtccagc
     4681 tggtccgagg agctgtacga gatcttcggc aggccgctcg actccgcccc cctctccctg
     4741 gacgacctgc cgtccgtgct gctgcccgag gaccagccgg tgctcaccgc gatggtgacg
     4801 ggctgcctgg tagacggccg gccgatggac ggcgagttcc gcatcgtgcg acccgacggc
     4861 ggcacgcgca cgctgcacat gacgggcgag ccggtcctcg acggcgaggg ctgcaccgcc
     4921 tccatgtggg cggtcctgcg ggacgtcagc gagctgcgcc gcagcgagca ggctgtgacc
     4981 cgcagccgtg cgtcggtcca gcgcgaggag cacatcgagc gcaccgagca ccgcatggcc
     5041 gtggagctcc aggagaccgt cctgccgccg tggcgcggat cactgcgcct cccgccgcag
     5101 ggccccggcg ccctggacat cgcggcgcac tacctcccct ccgcgtcgag cgggctcatc
     5161 ggcggcgact ggtacgacgc gatggagctg ccggacggac gcaccctcct caccgtcggc
     5221 gacctcaccg gacacggcat ccccgccacc tcggcgatgg cgatgctgct gggcgcactg
     5281 cggggcatgg ccgtcgccgg catcgagccg ggcgcgctga tgggacacct caaccgggtg
     5341 ctggagacgt cgatacagcc cgcgctgggc agcgccctgt gctgccgctt cgaccccggg
     5401 acctccgttc tctcctgggc gcaggccggt catcccgcgc cgctgctctt ccgcggcggt
     5461 tcgggaaggg tgctgccccc gccggacggg atactgctgg gtgccgcgcc ccaggccgtg
     5521 ttcgagcagg acgaggtacg gctcttcccc ggcgacgtgc tcgttctgca caccgacggg
     5581 ctgacccgac gcggcgaccg gggtgcgggc ccggaagcac tgctcgccct cgcccctcgg
     5641 ttcgccgacg cccgtacggc acaggagtgc gtccggggtg tcgtcgagga gttcggcggg
     5701 accgagcgcc tggacgacgc gtgcgtgctg gtcgcccgca tcggggcgtg agggaacgcg
     5761 gacgtatcag ggcatgccgc agaagcgcgg ccgtgtcagg gcgtgaagga gcccggagcg
     5821 gcgcggtggg gccggttcag atctgcgtgc ccctggcctt cttctggctc ggcatcgaca
     5881 gctcgatctc ctcgcgcaga tcctggatgc ccgcgtatcc ggcgaactga ccggtgagcc
     5941 ggtacatctc acggagccgg tcccaggtgc ggtgcgagga ggtctccccc atcgacacca
     6001 gcgcgagccg ggcataacgg tcggcctgtt ccgggtcgtt ggcgatgaag caggcggaag
     6061 cgagcgagat gtagtcgaag atcttcgacc gctgacgccc gttgacccgc agctccagcg
     6121 cctgcttggc gtggcgttgg gcgatgaccg ccgcccccgg gtcgtgctcg gccagcgtac
     6181 ggaaggcgag cgcctgcatg ccgtgcatat cggcctcgtc gaacatctgc atccaactgg
     6241 gcggcgggac atcgctcttg tccgagacga agagctcctc ggcctcgccg agggtgcgcc
     6301 gcatggcctg gccgcgtccc atggacgcct gcgcccaggc ctcgatggtg cgcagcatcg
     6361 cctgcgtacg gggcagggtc tcgtcgccgg aaccggattt ggcgagcttc atcaggtcga
     6421 gtgcgtcgtc ggggcggccc aggtgcacca tctggcgtgc cgcgcgggag agcgcctctc
     6481 cggcgcgtgg ccggtcgccg ccctcgcggg ccgcgtgggc ggcgatgacg aagtacttct
     6541 gggcggtggg ttcgaggccg acgtcgtggg acatccagcc cgccaggacg gcgaggttgg
     6601 cggcgacgcc ccacaggcgg cgctggaggt ggtcggggtg gcggtaggcg agcatgccgc
     6661 ccacctcgtt gagctggccc acgaccgcct tgcgctggag tccgccgccc cgggacgcgt
     6721 cccaggcgcg gaagacctcg accgagtgct ccagggccgc gatctcgtcg gagccgaccg
     6781 gtgcggcctc gtaccggtcg agaccggcgg gatcggcgtg caggggggcg ttggtccgtg
     6841 gcgcgtcggc cgccggagcg gggtcgctgt gcagccagtc gtacatgggg ccggcgatgg
     6901 ttgagccggc ggcgagcgcg gcgcccgcac ccaccaagcc gcgtcggttg agcatgaggt
     6961 ccattcccgt gaattcggtg aggaccgctg ccgtccgttc gggcgcccac ggcagttgat
     7021 cgggattgtg ttccgtcccg gagtcacgcc gtttccccac acgcccgcgt cggccgaacc
     7081 cgaggtcctc gatggtcacg acacggccga gccgctcggt gaacagagct gccagcactt
     7141 cgggcacggg atcacggggg gactccccca tgtcgatcca gcgcctgaca cgcgaggtgt
     7201 cggtggccag ctgcgggtgg cccatggccg ccgcctgccg gttcaccatt ctcgcgagtt
     7261 cgcccttgga ccagccggcc aggccgaaca ggtcgctgag acgggtgttg ggttctccgg
     7321 tcacttcaag cccccaggtt ctcggctgac ttgacattaa ccccctgtca gatgcgctgt
     7381 gactattcgc cagggttcgc cagggtccgc cagatggtct gccacccgtg acccgttgtc
     7441 aggtaggagt gcgccacccc gcccggcagc cctaggtact ccccagggtg ccgaacggcc
     7501 gtcggccggg ttggcgcacg taccttgtcg gcgcacgaag ggatctgtct cgcccatgta
     7561 cacagcatcg tcctccgtgt ccgccccgcc ccgtccgctc cgcccgatgg gcgcgggcgg
     7621 cgggccctat ctcgctcctc acgccggtgc gccggtgcag ggtccgggcc gggcccgacg
     7681 ggccgcggga ccgggcgccg gaccgctcag cggaaggatc gacctgtccg ggccgcaggg
     7741 cgcgcaggtg cggatggcca tcgcctccgt gcagcgcatc tgccccgagt tcaacccggt
     7801 ccaggtgctg cgccgcagcg gacgctcggt cctgatcgtg ggaacgaccg ggcgggcgac
     7861 ggccgtggcg aagtgtttac tggaccactc gccggcgtgg accgagcggt tccggcacga
     7921 aatagcggcg taccgcgcgt tcgtccggca ccggcccccg gttcgggtgc cccggctgat
     7981 cgcggcggat ccggagaact gcacgctggt gatcgagcgg atgcccggcc gggtcgccgc
     8041 cctcacccgg cacccggcgg aggcgccgcc gcgagccgac atccgtgccg ccctgggtgc
     8101 gatcgcccgg gtgaacgcct ggcggccgcc gcccggactg ttcgaggcgc cgctcgacta
     8161 cgcctcgcgg atcgcccgct accacgagct cggcctgttc accgaccgcg acctcggtga
     8221 cctgcagaag ctgctgcacg gtctggctca cgcgggcggc cggcagggca tggggcagtt
     8281 ctgccacggg gacgccctgc tctccaacat cctgctgtcg ccgaccggac cggtgctcgt
     8341 cgactgggag cacgccggct ggtatctccc ggggtacgac ctggcgacgc tgtgggcggt
     8401 gctgggcgac gcaccggtgg cacgccgcca gatcagccag ctggcccagg ccaggggccc
     8461 ggccgcgcgg gacgcgttcc tggtgaacct gatgctggtg ctgacccgcg agatccggaa
     8521 ttacgagacg gcggtacagc gcaccatgcg ggaggcgccc gcggtgggtg cgggggcgga
     8581 ccgccccggt gcgctctcct cgggtgagga gcagcggctg ctgctgcgga ggctgcacga
     8641 cgactgcgcg atggcgcgga gggcggtgcg ggcggcggtc ggcacccgct gaggcgggac
     8701 gacgccgacg gagagaagag ggcggggccg gaggcctgcc cgtcgaggac cgcggtgccc
     8761 agtcactgcg ggcccagacc actgcgaaaa agaagcgcgc tgcgggaccg gtgccgacac
     8821 accggtcccg cggcgcgctg ttctgcgttc ggtgaccgcc tgctgaccct gtgccgttcc
     8881 ggggtccctc gcgggtgagg cccgccacga gacccacgtc acctacgacg tccggtagta
     8941 ggcgcgagcc ctcccgtccg gcgtaacgaa ccgcccatat ggctcataaa ttggcatctc
     9001 acgatgaaga gtagtaaagg cggtcattgc ttcctatgtc ggtgcccgct aaccatggat
     9061 tccggcaggc accgagttcg agcccgcgtc gatcgcccac cggcgaccgc ggcccggacg
     9121 gcccggtacc cgccgacgcg gcgcgaaggc cgcgaagccc gtcccccata ggaagagctc
     9181 acgcatgccc cgcatctcca ccctgcgcat cacccgctcg cacaagatcg ccaccgccgt
     9241 gctcgtcgcg gccggttccg tcaccgccat aaccgccacc ggcggcccga gcgaagcgca
     9301 gaccaccgcg acccagtcct ccgtctccgt ggagccggtc gccgccgcgg gcatccccac
     9361 ggcgaaggac gctgccgaga aggccgcgaa ggagaacgcc gccaaggaag ccgcggcgaa
     9421 gaaggccacc gccaaggcgc tcgccgagaa ggagcgctcc gagaagcagg ccgccaaccg
     9481 gtccaccgag cgcaaggccg tcacgccgaa gaagtacgcg aacaacctcg acggctggat
     9541 ccgcgagtcg ctcgacatca tggagaagaa gaacatcccc ggctcctacg aggggctgca
     9601 ccgcaacatc atgcgtgagt ccagcggcaa cccgaacgcc gtcaacgact gggacatcaa
     9661 cgcgcggaac ggcattccct ccaagggtct cctccaggtg atccagccca ccttcgacgc
     9721 gtaccacgtc aagggcaccc cgaagaacct caccgacccg gtcgccaaca tcaccgccgc
     9781 cgccaactac gccgcggacc ggtacggctc gatcgacaac gtcgactccg cctactgagc
     9841 cggcctgccg agtcggcctg ctgagccgac accccagacg tgccgatgat gtgactaatt
     9901 gtcatcgtgc gtgccccgga tggccgaagg gtagtgctgc gcggacacca ccggtccgcg
     9961 cgacttttcg cgcggaggct tctggaaagg cccgacgcac atggcacagc ccttctcact
    10021 gccggacttc tatgttccgt atccggcccg gctcaaccct catgtggaag cggcacgctc
    10081 gcacacccgg gagtgggccc gctccatggg aatgctggag ggatccggca tctgggagga
    10141 gaaggacctg gaggcgcacg actacgccct cctgtgcgcc tacacccatc ccgactgctc
    10201 ggcggaggcg ctcagcctcg tcaccgactg gtacgtgtgg gtcttcttct tcgacgacca
    10261 cttcctggaa ctgttcaagc gcacacccga ccgggcgggc ggcaagcggt atctggaccg
    10321 gctgcccgcc ttcatgccga tggagcgcgg ggccgcgaca cccgagcccg agaatcccgt
    10381 cgaggcgggg ctcgccgatc tgtgggcccg gacggtgccc gcgatgacgg acgactggcg
    10441 ggcccggttc gcggagtcga cggagaacct cctcaacgag tccctgtggg agctcgccaa
    10501 tatccacgag ggccgcatcg cgaacccggt ggagtacatc gagatgcgcc gcaaggtggg
    10561 cggcgcgccc tggtccgcgg gcctggtcga gtacgcggcg gacgcggagg taccggcgtc
    10621 ggtcgccggg tcccggcccc tgcgggtgct gcgggacgcc ttctccgacg ccgtacacct
    10681 gcgcaacgac ctcttctcct accagcgtga ggtggaggac gagggggaga acagcaacgg
    10741 cgtgctggtg ctggagaagt tcctcggctg ctccacgcag gaggccgccg atgccgtcaa
    10801 cgacctgctc acctcacggc tccagcagtt cgagaacacc gccctcaccg aactcggccc
    10861 tctctgcgcc gagaaggccc tcgacccggc gcagaccgcg gccgtgctgg cgtacgccaa
    10921 agggctccag gactggcagt ccggcggcca cgaatggcac atgcgctcca gccgctacat
    10981 gaacggcgga ggcgcgggcg aggccgtggc cggctggggc atgtccgcgg cctccatcag
    11041 gttcaccctc cgctcggaga ccgcgcggtc ccgcagccac agccacgtgc cgtaccagca
    11101 cgtgggcccc tcgctgctgc cggacttcga cctgccgttc ggcacgacac tcagtccgca
    11161 tctggagggg gcccgggtcc ggctcgtcga gtgggcgcgg cggatgggca tcctggaggc
    11221 ccagccgggt gtgccgggtt cgcacatctg ggacgagcgg cggatcgtcg cgatcgacct
    11281 gccgttgtgc gcggccggcc tgcatccgga cgcgaccccg gacgaactgg acctgtcctc
    11341 gggctggctg gcctggggga cttacgggga cgactggttc ccggtggtgc acgggcgggc
    11401 ccgggacctg gcgggcgcgc gcctggccaa cgaacggctg tcgctgttca tgccgctgga
    11461 cggggagggg acgccggagc cggtgaacgc tctggagcgg agtctgggcg acctgtggcg
    11521 caggacggcc gcgccgatgg accagggcgc gcggcgcacc ttccggacct cgatcgagtc
    11581 gatgaccgag agctggctgt gggagctggc gaaccaggcg cagaaccgca tccccgaccc
    11641 ggtggactac gtggagatgc gacgggcgac gttcggttcg gacctgacga tgagtctgtg
    11701 ccggctgggg cacggcagga ccgttccgga agaggtctac cgcagcggcc cgatgcggtc
    11761 cctggagaac gcggcggcgg actacgcgtg cctgatgaac gacctgttct cgtaccagaa
    11821 ggagatcgag tacgagggcg aggtgcacaa cggcgtcctg gtcgtgcaga acttcttcgg
    11881 cgtggactat ccgacgggcg tggcgatcgt gcacgacctg atgaactcac ggctgcggca
    11941 gttcctgcat gtggccgagg tcgaacttcc ggtgctgtac gacgatttcg gcctcgacgc
    12001 cgaggcgcgg gaggtcctgg cgggctacgt gcaggagctc aagcactgga tcgcggggat
    12061 cctgatctgg caccggggct gccgtcgcta ccgcgaggag gacctgcggc aggggaacga
    12121 caccccctgg cacctcggcg gtcccacggg gatcggcaca tcggcggcgc aggtgacccg
    12181 gatgatggcg cagttggcgg gcagccgggg ctgacccccc ggccgtaccg ggagcagggt
    12241 ccgccgtggg ggttctcacg gcgggccgtg gccggatccg ggcgcggatc ccgacgcggc
    12301 cccggtcaga gcaggacgtg tcgcagcact gcctcgaact ccgccgccgt cggcggtgtg
    12361 tcggtcagca gtccctggag gagcagtccg tcgatgacgc ccttgaggat ctgcacccgg
    12421 accgggtcgt cggtgtagcg cagggcgtat ccggcgatgg cgtccagcca gcgtccggtg
    12481 gaggtgcgca gctccggccg ccgggcggcg agcaggtaga gctcgtactc ggcgaggagc
    12541 cggccggggc ccttcatcac gtgtccgagg agttcggcga gggcggtgag accctcgggg
    12601 ccgccatcgg cgctctccgc caggcgtcgc atccgttcgg cgtcctggtc catgcagacg
    12661 gtgagggcgg cggtgagcag gtcgtcgatg ctcttgaagt agtaggcggc ggcggtggcg
    12721 ggctggttcg cctcgcgtgc caccgcccgg tggctgacgc ccgcgacgcc ctcgcgggcg
    12781 accacccgga gggtggcctc gatgagttcc tgccgtcgga gctcgccctt gagcaggcgg
    12841 ccgtcggtcg gtgacggggt catcgtgccc tccgggcgtc gtggtccagc ggtacggaag
    12901 cggggtgccg ttcctcgtgg ccgcggggcg tccgtgggac cggcttcgcg tccccttcgt
    12961 ctgcgggcgc ctcggcgcgc gcccgcaggc tccggtcgag cgggccctgg gcggtcagcg
    13021 ccaggagcac cgtcgcgccg cccgcggcga gggccacggt gaagccgccg gaggggccga
    13081 agcggtcgac cataccgccc gacaccgagg caccgagcgc gacaccgacg ctgaggccgg
    13141 tgatcgccca ggtcattccc tcggtgaggg cggccggctc caccgtcttc tcgaccagtc
    13201 ccatcaccac gatcatggtg ggcgcgaaga agaggccgga gaagaagacg gccgcggaga
    13261 gcgtggcgat gttctctacg agcagcaggg gaagggtggt cagggcggtg ccggcggtgc
    13321 tgaggaggag cagccggggc agagggacgc cgagccggag ggcgccgaac accagcccgg
    13381 cgccggccga gccgatcgcg tagacggaga ggacgatgcc cgcgccggcc ggtgatccct
    13441 gcgcctcggc gaaggcgacg ctcaccacgt cgacggtgcc gacgatcgtg ccgcccgcga
    13501 cgagggtgag ggccagcagg acgagtggtc ccccgcgcag cgccgagacg cgcggggcgc
    13561 cgtcggcggc cggcctgagc accggcggct cggtgcgctt ctgcggcacg aacatcagga
    13621 cgccgagggc gagcagcacc gccgccacca gtggcccggc ctccgggaag agcgcggtgc
    13681 tcagtgcgac cgcgagggct gggcccacca cgaaggtgag ttcgtcgacg accgattcca
    13741 gcgagtaggc ggtgtgcagg cggtccgagc cccggtggag atgggtccac cgggcgcgga
    13801 ccatcgcggc catgttgggc atcgtgccgg ccgccgccgc actgacgaac agcgtccaga
    13861 caggggcgcc gtagcgggcg cagaggagga gcacgcccat ggcgatgaca ctgaggccgg
    13921 tggcgggcag cagcaccctg ctctgccccc gtcggtcgac cacccgcgag atctgggggc
    13981 cgcagagggc catggacagc gtgaaggtgg cggagacggc ccctgccagg ccgtactgcc
    14041 cgcgcatctg ggacaacatc gtgatgatcc cgatgccggt catcgacagc ggcatgcggg
    14101 cgacgaagcc cgcggcggag aaggccaagg agcccggcgc cctgaagaga gcgccgtagg
    14161 gattggccat ggggacggac ctccggacgg gggaaacgat gaacctgaac gaccgttaca
    14221 cattgaacgg tcgttacatt ttcttggcgt agtcgctccc ccgccgtcga tgtcaaggga
    14281 agccgccggc gtcaagggaa aaggccgccc gaacgaattc ggacggcctt gcgaccggac
    14341 ggttttgcga agggacgttt cagccttgct ggaacagctc cgcgggcagc ggcttgagca
    14401 gggtgtagag gtcgtcggtg atcggccggt cccagctggc gatggtcacg aggacgccgt
    14461 cgctgcggtc gaactggacg caggcgatcc ggctctcgga gagcttgacg cggcggacga
    14521 tcagcagatt gtcgccctgc atgacgggga cgtcctcgga gctgacgacc tcgatcggct
    14581 cgtcgttctc cagggcgagg agcagctggg ccacctcgaa ggggacctgg ccctcctccg
    14641 tctcgcgggc gggcgagcct tccggcaggt tgccgatgat catcgccggg ccccgtccgc
    14701 cgtacaggtc gtagcggagg aagacgccct ggcagctgcc gtcgggggcg gggagcagac
    14761 cggcgccgag gttgccgggc cagtccccgg ggtccatggc caggacgtcg aagtccgggc
    14821 ccgcgggtgt tgcggcgcta cggcggcgga ggaaggacat gcctgccatg ttacgtgtcc
    14881 cggctcacgt tgcggagccg ggcccgggcc gcgcgggacc cggcccgaca tgtcttctcg
    14941 gccgggccgg ggctccgctt gccagcccgc cgggacctcg cttctcagcc gggcgggggc
    15001 tcggcgccca cgagccacat ggcgaagaac tgggacccgc cgccgtaggc gtggccgagc
    15061 gcccgggtgg ccccgtcgat ctggtgctcg ccggctctcc cccggacctg gagggccgcc
    15121 tcggcgaagc ggatcatgcc ggaggcgccg atggggttgg tggacagcac accgcccgag
    15181 gggttgacgg ggaggtcgcc gtcgagttcg gtgacgcccg cctcggtgag cttccagccc
    15241 tcgccctcgt cggcgaaccc gaggttctcc agccacatcg gttcgtacca cgagaacggc
    15301 acgtacatct cgacggcgtc gatctcacgg cgcgggtcgg tgatgcgggc ctgccggtag
    15361 acgtcggcgg cgcattccct gccggcctgc ggggagacga agtccttgcc cgcgaacagg
    15421 gtcggttcgc tgcgcatcgc cccgccgtgg acccaggccg gcgggtgcgg ggagcgggcc
    15481 gcgccgtccc ggccggtgag gatcatggcg caggccccgt cggacgaggg gcaggtctcg
    15541 gagtagcgga ccgggtccca gagcatcggc gaggactgga ccttctccag ggtgaggtcg
    15601 tggtcgtgga tgtgcgcgta ggggttcttc agcgcgttgc ggcggtcctt gtacgcgacg
    15661 agcgagccga ccgtgtcggg cgctccggtg cgccgcatgt acgcgcgcac gtgcggggcg
    15721 aagaagccgc ccgcgccggc cagcagcggc tgctggaagg ggacgggcag ggagagcccc
    15781 cacatggcgt tggactcgga ctgcttctcg aaggcgaggg tgaggacggt gcggtgtacg
    15841 cgggcggcga cgaggttcgc ggcgaccagg gccgtcgatc cgccgacgga gcccgccgtg
    15901 tggacgcgga gcatgggttt gccgacggcg ccgagggcgt cggcgaggta gagctccggc
    15961 atcatgacgc cctcgaagaa gtcgggcgcc ttgccgatca cgacggcgtc gatgtcggcc
    16021 cagcccagcc cggcgtcctc cagggcgcgg accgccgcct cgcggacgag tccggcgatg
    16081 gagacgtcgt gccgggcggc gacgtgtttg gtctggccga tgccgacgac ggcgacgggc
    16141 tccttactca tgagcgctct ccccttccag gacggcgacc aggttctgtt gcaggcaggg
    16201 cccggaggtg gcgtgggcaa gggcccggtc ggactcgccg cggtggatgc gggcggcggc
    16261 ctcgccgagc cggatcagtc cggcggccat gaccgggttg gcggcgaggg cgccgccgga
    16321 ggggttgacg ctgacctcgt cgccgagccc gagcgccttg cgcaggacga cttcctgcga
    16381 ggtgaacggg gcgtgcagct cggcggtgtc gacgggccgt tcgaaggctc cggcgtgttc
    16441 ggcggcgagc cgggcggagg ggctgtcggt caggtcgcgg acgccgaggc tgtgggcttc
    16501 gatgcggtgg tcgatgcccc ggatccaggc ggcccgttcg cacagggcgc gggcggtgtc
    16561 cccggcggcc aggaccacgg cggcggcccc gtcgccgatg ggcgggcagt cgccggtgcg
    16621 cagcgggtgc acgaggtggt cgcccgccgg gacgtcgccg gtgagctggg cgtacgggtt
    16681 gtcgacggcc gcggtgcggt tgcgggcggc gatctgggcg agggctcctt cgtcggtgtc
    16741 gcccgcgtcg atgagggcct gggcctggag ggcggcgagg gcgacggagt cgggccagag
    16801 cggggcgaga tagtaggggt cgagctggcg ggtgagtacg tcgcggaccc ggccgggcga
    16861 ggacttgccg taggagtaga cgagcgcggt gtccgcctcg ccggtccgga gcttgaccca
    16921 ggcttcgtac agcgcccagg ccccgtccat ctcgacgtgc gactcggaga tgggcgggtg
    16981 ggcgccgacg ccgtcgagcg ccatggtgaa ggagaaggcc cgtccggcga ggtagtcggc
    17041 ggagccggag caggtgaacc cgatctcgtt ggccttgagg ccggtcgcgc ccaggacctc
    17101 gtggaggacg ggcatcagca ggtcgacctc ggagagctcg tcggtacgcc gccggtgcgc
    17161 gctctgggcg aaggcgacga tggccacgtc ccgcatctac accagctcct tgtacgtgtc
    17221 gtagtcggcg tcgggctcgc cggtgggccg gtagtggtcg acgtggcggg acccccgacc
    17281 agcaccggtc cagacgggct cgacgcgcag gcccatgcgg acctggtcgt aggggattcc
    17341 ggcgatgcgt ccgtgcaggg ggaggtccgc gccgtcgagg gcgatgtggg cgtatacgta
    17401 cgggacttcg atgtcgagat tcttcgcctt gatgttgacg atgcagaagg tggtgaccgt
    17461 gccgcacggt ccgacctcga cctgttcggc ggtggcgacc ccgcaggtgg ggcaggcgcc
    17521 gcgcggcggt acgtagacct tgcggcaggc ggggcagcgt tcgccgacgg tacggcgttc
    17581 ctccagggcc ttgatgtagg cactctgggc gcggccgggg gtgtggaggt agtcgaggcg
    17641 ggccggggcg acgatgccgg tgacggggtc ggcgaactca ccggtgtgcg gggcgggttc
    17701 ggtggggccg ggctcgccct cgtacggttc gaagcaggcg atgtcggtga tggcgccggt
    17761 gcgggtggcg gcccagcgga tgcggacgcg catcccggtg cgcacggcgt cgggtccggg
    17821 tgcgtcgagt acgtgcagga gcgcggtgcc ggctccgtcg aggcggacga ggacccaggc
    17881 gaacggggtg tcgagcggct ggtcgcggcg cggggacggg ttccaggccc aggtggtgac
    17941 ggtgccggtg ggggcgacct cgacgaggtc gcccagttcg ttcgcggaga ccgggtcgta
    18001 ttcgacgggc ggtacgagga ccgtgccgtc gtccgtgcgg acgccgagga cggtgcgttc
    18061 gcgcagtccg gtgaggaagg cgctctggac ggggccgagc gagcgggtga aggggaattc
    18121 gaccaccagc ggggcgctga ggacgtcggg catggctctc tcctggggtc aggcgcgccg
    18181 gtagacgggc gggcgcttct cggcgaaggc gcgggcgccc tccttggcgt cctcggtggc
    18241 gaacacgggc cagccgcgct tgagttcggc ggccagggcc tcgctctcgg tcagctcggc
    18301 gccctcgtag acggaggcct tgacggcctc gacggcgagc ggcccgcagg cgttgacccg
    18361 ttcggctacg gcgagggcct cctccagcgc ggcgccgtcg ggcacgaccc tgccgatgag
    18421 cccgatggcg gcggcttcgt cggcggtgta cgggcgtccg gtgaggagca tttcgagggc
    18481 gtgggtgcgg ggtatctggc ggggcagccg tacggtggag ccgccgatcg ggaagaggcc
    18541 ccggcggacc tcgaagagcc cgaaggtggc tccggctccg gcgatgcgga tgtcggtgcc
    18601 ctggaggatc tcggtgccgc ccgcgacaca ggggccctcc acggcggcga tgaccggttt
    18661 gcgggggcgg tggtggcgca gcatcgcctt ccagtgcaga tccgggtcgg cggtcatccg
    18721 ctcgcggtac tcctcccccg ccattccgtc gcccgcgagc gccttgaggt ccatgccgga
    18781 gcagaacgcg ccgcccgcgc cggtgaggac gacggagcgg accgtgtcgt ccgcgtcggc
    18841 ggcgagccag ccgtcgtaca ggccgacgag catcggcaac gagagcgcgt tcctggcctg
    18901 tggtctgttc agggtgagca ccagtgtggc gccttcgcgc cgcacggtga ggtgttccgt
    18961 accgcccatg acggactcct gttctccgga tctggaacag gttgcaggag gagggggcgc
    19021 agttcaatag ttttctgaca gctcgtcaga ttgttgcgac gccacctctt cccacttgtg
    19081 ccgaccggcg ctctaatgac ggccgagtcg ccagtcaccc ggggtcagga ggaacggtgg
    19141 agtacaacct tgccgacctg ttcgagtcgg tcgtcgacgc ggtgcccgac cgtgaggcgc
    19201 tcctgtacgt cgaccatccc ggtacgggcg cggagcgccg gctcacgtac gcggagctgg
    19261 acgccgccgc gaaccgcatc gcccaccacc tgatcgacgc ggggatccgg ccgggcgagc
    19321 acctggggct gcatctctac aacggggtgg aatacctcca gacggtgctg ggagccctca
    19381 aggcgcggat cgtgccggtg aatgtcaatt accgctatgt ggaggaggag ttggtctacc
    19441 tctaccggga cgcggacctg gctgcactgg tcttcgacgg cgagttcgac gagcgggtgg
    19501 cggcggccgc cccgcaggcc ccggggctgc gccatctggt ccgggtgggg ccctctgcca
    19561 cgacggccgc ccccgggccg gtggccgtgc ccttcaccga ggcggaggcg tccggctccc
    19621 cggaccgcgg tttcaccccg cgctccgccg acgaccagtt catcatctac accggcggca
    19681 cgaccggcat gcccaagggc gtgatgtggc gtcaggagga cctgttcttc tcgggactgg
    19741 gcggcggcgc accgaccggc gagccggtga agaccccgca ggaactggcg gagcgggtcg
    19801 cggcgggcgg cgacgggatc accttcttcc ccaccccgcc gctgatgcac gggacctcca
    19861 cgctgaccgc gttcatcggc ttcaacttcg gccagcgcgt cgtcgtgcac cgcaagttcg
    19921 ttccggaaga ggtgctgcgg acgatcgaga aggagaaggt cacgagtgtg tcgctggtcg
    19981 gcgacgcgat gctgcgaccc ctgatcgact gcctgaaggg ggcgctgcgc gggacggact
    20041 gctcgtcgct gttctccgtc tccagctccg gggcgatcat gtcggattcg gtgcgcgcgg
    20101 aattccagga gctcgtgccg acggtgatgc tgctgaacaa cttcggctcc tccgagtccg
    20161 gcttcaacgg cacggccacc gccgactcgg gacccgagaa gggcttccgg gtccaggtca
    20221 acgcccgtac ggcggtggtg gatccggtga cgtacgagcc ggtggcaccc ggcgagccgg
    20281 gccgtatcgc ccagcgcgga catgttccgc tcggctacta caacgacccg gccaagaccg
    20341 ccgacacctt cttccgccgg ggcgacgagc gctgggtgct gctgggcgac atggcgaccg
    20401 tggacgcgga cggcatcgtc acggtcctcg ggcggggctc gcagtgcatc aacaccggcg
    20461 gcgagaaggt gtatccggag gaggtcgagc aggcgctcaa gtcgcatgcg gatgtgtacg
    20521 acgcgctcgt cgcgggcgtc cccgacgagc gttggggaaa ccgggtcgcc gccgtggttc
    20581 aactgcgcga gggagtagca gcgttgacct tggaggcggt gcaggcccac tgccggaccc
    20641 ggctggccgg ctacaagatc ccccgcgcgc tggtgctcgc cgaccggatc cagcgctcgc
    20701 cgagcggcaa ggcggactac cggtgggcga aggcggtggc ggcggaggcc caccggagct
    20761 gaacggccgg ggccgaccgg gccgaccgga gctgaaggac gggggcctcc cgcctgcccc
    20821 gggcgctgat cgtcaaggcc ccgtcgccga tcgtcaagga cagagcggga agtgatccgc
    20881 agactggtgg gtgtcgggat gcccggcgcc gcgggggtgc gtcggacgcc cgactccgct
    20941 tacgctcgca cctcgcacct gcgctttcat gctcgaacgg ggaagagatc acagtgagtt
    21001 cgccgctgac acaggtcgat ccggagcgcg tcggggggta ctggctcgcc gccagactgg
    21061 gtgccggcgg acagggcgtg gtgtacgagg cgtacgacgc gtccggggac cggttcgcgc
    21121 tcaagacgct gcaccgggcc gccgatccgt tcctgcggga gcggttcacg cgggaggcgg
    21181 aggcggcccg gcgggtggcc ccgttctgca cggcgaggat cgtgcgcgcc ggcgtcgacg
    21241 gcgaaatccc ttatctggtc agcgagtacg tgccggggcc ggccctcgcc accgccgtac
    21301 gggagaacgg gccgtcgtcc ccggacgcgg tgctgcggct ggccaccggg atggcgaccg
    21361 cgctggccgc gatccaccag gcgggcgtcg tgcaccggga cctcaagccc gggaacgtcc
    21421 tgctgggccc ggacggcccc cggatcatcg acttcgggat cgcccgggcc ccggacatgt
    21481 ccctcaccgc caccggcgcg atcatgggga cgttcggcta catggccccc gaggttctgg
    21541 ccgggcagcg ggcgaccgag gcgtccgacg tgttcgcgtg ggccgccgtc gtgctgtacg
    21601 cggcgaccgg tacggagccg ttccggggcg agaacatcgc cgaggtcgcc caccgcacca
    21661 ccaccgtcga gccggatctg ggagcgctgc ccccggcgat acggccgctc atggccgcgg
    21721 ccctcgccaa ggatccggag ctgcggccca ccgcggccga tctgctgctg ggcctggtcg
    21781 gcgcccccgt caaggcggcg gacccccggg ccgcgctgat ggaggcgggc gcccggaagg
    21841 ccgccgccgc gcccgaagcc gacaacccga aggcgaccgt cacggaagga gcgggcggcg
    21901 aggccggagc ggccggcgtc ggcggggagg ccggcgtcgg cgggaccgtc gtggaggcgc
    21961 ccctcgggga gcgtgcggag gcggccttcg cggcgctctc ccccgccgcc cggctcgccg
    22021 cccacgggct gctgctccgc ctcaccgtgc cgggggccgc gccggacggc tcccaggact
    22081 ccgtgcgcac cgcccacccc gacgaactgc tggccgaccg gcccgaggac gaacaacagg
    22141 aggtcaccgc cgccgcccag cggctcctgg ccgccggggt cctcgtgtcg gaggcggacg
    22201 gcgccctgcg gccg
//
