MIBiG Protein Description MIBiG Cluster MiBiG Product % ID % Coverage BLAST Score E-value
BAG17639.1 putative_cytochrome_P450 BGC0001043.4 NRPS:Type I+PKS 86.0 96.2 668.0 4.17e-244
QGU18623.1 cytochrome_P450 BGC0002365.2 other:other+PKS 82.0 96.5 644.0 1.68e-234
QNS30810.1 cytochrome_P450 BGC0002509.3 NRPS:Type I 72.0 96.5 555.0 4.4e-199
EFL02198.1 cytochrome_P450_hydroxylase BGC0000996.5 NRPS:Type I+PKS:Iterative type I 60.0 97.5 454.0 3.16e-159
AAT09797.1 NocL BGC0000395.5 NRPS:Type I 41.0 96.2 242.0 2.56e-76
ANC94978.1 AlmPIII BGC0001396.5 PKS 37.0 97.0 231.0 9.67e-72
AAS79447.1 P450 BGC0000035.5 PKS 37.0 97.0 229.0 2.7e-71
OKI81353.1 cytochrome BGC0002478.3 PKS 39.0 93.0 229.0 4.94e-71
ABB52528.1 cytochrome_P-450 BGC0000047.5 PKS 37.0 97.0 229.0 5.36e-71
AAF81737.1 putative_p450_monooxygenase_EncR BGC0000220.4 PKS:Type II 40.0 96.0 228.0 1.27e-70
ctg1_orf528 BGC0001199.5 PKS 37.0 93.0 227.0 1.84e-70
AAS79446.1 P450 BGC0000035.5 PKS 39.0 92.2 225.0 1.4e-69
ABB52529.1 cytochrome_P-450 BGC0000047.5 PKS 38.0 92.2 224.0 1.97e-69
ANC94979.1 AlmPII BGC0001396.5 PKS 38.0 92.2 225.0 2.58e-69
QIC03931.1 EncR BGC0002366.2 PKS 40.0 96.0 224.0 2.77e-69
ARS01480.1 NcmG BGC0001702.3 NRPS:Type I+PKS 40.0 92.5 222.0 1.37e-68
QIC03958.1 CyaI BGC0002347.3 other:other 37.0 94.0 220.0 1.29e-67
AFO59870.1 ChxI BGC0000175.5 PKS:Trans-AT type I 39.0 92.2 219.0 1.5e-67
ACB47070.1 putative_cytochrome_P450_hydroxylase BGC0001060.5 PKS 39.0 99.2 219.0 1.77e-67
BAK64643.1 putative_monooxygenase BGC0000135.5 PKS 37.0 92.5 218.0 8.31e-67
AAN85539.1 cytochrome_P450_hydroxylase BGC0001101.5 NRPS:Type I+PKS:Type I 36.0 95.0 217.0 1.27e-66
QIC03956.1 CyaG BGC0002347.3 other:other 37.0 101.3 218.0 1.41e-66
QIC03957.1 CyaH BGC0002347.3 other:other 38.0 93.0 216.0 2.86e-66
BAL90275.1 putative_cytochrome_P450 BGC0002021.3 PKS 39.0 92.7 216.0 4.83e-66
BAJ52696.1 putative_cytochrome_P450 BGC0000222.5 PKS 40.0 92.2 216.0 5.79e-66
BAJ52675.1 putative_cytochrome_P450 BGC0000222.5 PKS 37.0 91.7 213.0 8.84e-65
BAJ52677.1 putative_cytochrome_P450 BGC0000222.5 PKS 34.0 102.0 209.0 1.86e-63
AUD08664.1 cytochrome_P450 BGC0001553.5 NRPS:Type I+PKS 37.0 92.7 207.0 5.75e-63
UMP03496.1 NmvG BGC0002649.2 NRPS:Type I+PKS 38.0 92.5 207.0 8.74e-63
sipO1 BGC0001452.5 PKS 36.0 97.0 207.0 1.2e-62
ANW12113.1 putative_cytochrome_P450 BGC0001374.5 other:other 36.0 92.7 205.0 4.55e-62
OAP25810.1 Cytochrome_P450_107B1 BGC0001658.3 PKS 35.0 97.0 205.0 4.67e-62
ARW71482.1 cytochrome_P450_epoxidase BGC0001812.3 PKS 35.0 99.7 205.0 5.18e-62
QWM97863.1 cytochrome_P450 BGC0002434.2 PKS+NRPS:Type I 35.0 99.5 206.0 5.66e-62
AWR88406.1 putative_cytochrome_P450 BGC0001522.5 PKS 36.0 97.0 205.0 6.57e-62
ANY57978.1 Cytochrome_P450 BGC0001369.3 PKS 37.0 92.7 205.0 7.28e-62
BAB69197.1 cytochrome_P450 BGC0000117.5 PKS 36.0 93.5 205.0 7.66e-62
QLD23834.1 cytochrome_P450 BGC0002086.3 PKS 35.0 99.7 204.0 1.02e-61
ASZ00162.1 cytochrome_P450 BGC0001785.5 PKS 38.0 98.5 204.0 1.49e-61
AKG06374.1 cytochrome_P-450 BGC0001830.3 PKS 36.0 100.0 204.0 2.07e-61
AJD77035.1 cytochrome_P450 BGC0001435.4 NRPS:Type I+PKS:Iterative type I 37.0 92.2 205.0 2.46e-61
AFV52207.1 P450_monooxygenase BGC0000081.5 NRPS:Type I+PKS:Iterative type I 37.0 91.7 202.0 6.51e-61
ALA09370.1 cytochrome_P450 BGC0001303.5 PKS 35.0 92.7 202.0 9.24e-61
ABI22127.1 cytochrome_P450_hydroxylase BGC0000422.5 NRPS:Type I 37.0 96.5 201.0 1.3e-60
ABP55212.1 cytochrome_P450 BGC0000142.3 PKS 35.0 92.7 201.0 2.56e-60
AAG06719.1 cytochrome_P450 BGC0002037.3 NRPS:Type I 39.0 99.2 201.0 4.56e-60
ATY46590.1 cytochrome_P450 BGC0001666.3 PKS 36.0 92.7 200.0 4.75e-60
AWH12932.1 StmP4 BGC0001784.5 PKS 37.0 97.5 200.0 5.38e-60
DAC74143.1 cytochrome_P450 BGC0002019.3 terpene 36.0 92.0 199.0 5.65e-60
BAP34719.1 cytochrome_P450 BGC0000078.5 PKS 35.0 96.7 198.0 2.29e-59
CBA11565.1 cytochrome_P450 BGC0001046.5 NRPS:Type I+PKS:Type I+saccharide:hybrid/tailoring 36.0 98.2 198.0 3.08e-59
DAB41480.1 cytochrome_P450 BGC0001230.5 NRPS:Type I+PKS:Type I 37.0 96.0 197.0 4.63e-59
ABB69764.1 PlaO5 BGC0000654.4 terpene:Diterpene+saccharide:hybrid/tailoring 36.0 93.5 197.0 5.5e-59
AWO77090.1 cytochrome_P450 BGC0001556.5 NRPS:Type I+PKS 39.0 94.7 197.0 8.25e-59
BAF98633.1 putative_P450 BGC0000651.5 terpene 35.0 94.2 197.0 9.35e-59
QBG82535.1 cytochrome_P450 BGC0002587.2 PKS 38.0 91.5 195.0 4.28e-58
ABO15884.1 cytochrome_P450 BGC0000132.3 PKS 35.0 93.2 195.0 5.35e-58
ABM21756.1 PdmJ BGC0000256.3 PKS 34.0 97.2 191.0 1.3e-56
ABO15856.1 cytochrome_P450 BGC0000130.5 PKS 34.0 92.7 189.0 6.11e-56
QZA73303.1 cytochrome_P450 BGC0002385.3 PKS 35.0 93.7 187.0 3.64e-55
ABM21740.1 PdmW BGC0000256.3 PKS 33.0 92.5 187.0 4.22e-55
EFG10558.1 Cytochrome_P450 BGC0001310.5 PKS:Type III 34.0 97.2 188.0 7.25e-55
ACN29715.1 cytochrome_P450_hydroxylase BGC0000814.3 other:other 34.0 95.5 186.0 7.71e-55
WP_020636861.1 cytochrome_P450 BGC0002011.3 PKS 36.0 100.0 185.0 1.1e-54
AFI57027.1 cytochrome_p450 BGC0000133.5 PKS 35.0 97.7 185.0 2.39e-54
BAF02928.1 cytochrome_P450_monooxygenase BGC0000073.5 PKS 33.0 95.7 181.0 1e-52
AGI62224.1 cytochrome_P450 BGC0001335.5 other:other 37.0 91.0 180.0 3.23e-52
CCC55925.1 hypothetical_protein BGC0000973.5 NRPS:Type I+PKS:Type I 36.0 88.4 179.0 4.12e-52
AQM75237.1 NosC BGC0001707.5 ribosomal:RiPP 34.0 100.3 180.0 5.68e-52
ADB02836.1 AzicO2 BGC0000202.5 PKS 34.0 100.5 178.0 6.77e-52
ADE22287.1 putative_cytochrome_P450_hydroxylase BGC0000279.5 PKS 34.0 93.0 179.0 6.87e-52
ABV97164.1 cytochrome_P450 BGC0000137.3 PKS 37.0 97.5 178.0 2.22e-51
WP_003071780.1 cytochrome_P450 BGC0002009.4 PKS 36.0 92.5 177.0 4.34e-51
AGN74891.1 P450-like_monooxygenase BGC0000459.5 NRPS:Type I+PKS:Trans-AT type I 37.0 87.4 176.0 6.6e-51
ACR48332.1 NosC BGC0000610.5 ribosomal:RiPP:Thiopeptide 34.0 88.7 172.0 1.78e-49
ATY12795.1 cytochrome_P450 BGC0001504.4 PKS 33.0 95.5 171.0 8.5e-49
ANA09446.1 PriD BGC0001483.4 other:other 33.0 104.3 171.0 1.38e-48
CCP20055.1 divQ_protein BGC0001119.5 PKS:Type I 35.0 94.2 167.0 1.45e-47
QIE07135.1 OvmQ BGC0001719.4 PKS 35.0 92.0 166.0 1.46e-47
AJV88386.1 MfnN BGC0001214.5 NRPS:Type I 34.0 96.2 166.0 5.26e-47
ANH11399.1 SceD BGC0001770.4 PKS 33.0 99.5 166.0 7.02e-47
ADR01079.1 NocC BGC0000609.3 ribosomal:RiPP:Thiopeptide 32.0 94.0 164.0 2.89e-46
AAU93799.1 cytochrome_P450_oxidoreductase BGC0000054.5 PKS 34.0 94.0 164.0 3.72e-46
BBG06139.1 BGC0001917.4 PKS 36.0 89.2 162.0 1.46e-45
DAC74139.1 cytochrome_P450 BGC0002019.3 terpene 33.0 95.0 160.0 4.37e-45
AQM75238.1 NosB BGC0001707.5 ribosomal:RiPP 32.0 103.3 160.0 5.46e-45
QWT72280.1 cytochrome_P450 BGC0002430.3 NRPS:Type I+saccharide 35.0 86.9 161.0 5.99e-45
QGA70089.1 cytochrome_P450 BGC0002517.3 PKS 33.0 92.0 160.0 8.26e-45
BBC27536.1 cytochrome_P450_monooxygenase BGC0001529.5 other:other 31.0 96.5 160.0 9.15e-45
ABX71093.1 Lct10 BGC0000238.5 PKS 35.0 91.7 160.0 1.09e-44
ABB69759.1 PlaO4 BGC0000654.4 terpene:Diterpene+saccharide:hybrid/tailoring 31.0 101.3 159.0 1.48e-44
BAF02929.1 cytochrome_P450_monooxygenase BGC0000073.5 PKS 31.0 92.2 159.0 1.71e-44
AFW04584.1 cytochrome_P450 BGC0001783.5 other:other 34.0 103.8 159.0 2.19e-44
ABW00326.1 cytochrome_P450 BGC0000333.5 NRPS:Type I 35.0 98.7 158.0 5.21e-44
BAC76484.1 P450_hydroxylase_LkmF BGC0000085.5 PKS 33.0 89.2 157.0 1.06e-43
ctg1_orf525 BGC0001199.5 PKS 32.0 93.5 157.0 1.26e-43
AKQ20702.1 cytochrome_p450 BGC0001337.5 other:other 34.0 86.4 155.0 2.35e-43
CAC17503.1 putative_cytochrome_P450 BGC0000324.5 NRPS:Type I 35.0 94.2 154.0 1.2e-42
ACO31280.1 PtmO5 BGC0001140.5 terpene:Diterpene 33.0 99.5 155.0 1.24e-42
OKI81364.1 cytochrome BGC0002478.3 PKS 32.0 94.5 154.0 1.42e-42
QDQ37892.1 cytochrome_P450 BGC0001979.4 PKS 33.0 92.2 154.0 1.6e-42
AEK75512.1 cytochrome_P450 BGC0000001.5 PKS:Type I 33.0 92.0 152.0 4.55e-42
AKT74280.1 TxnO5 BGC0002141.3 PKS 32.0 92.0 152.0 6.01e-42
AAM94800.1 CalE10 BGC0000033.5 PKS 34.0 100.8 150.0 2.33e-41
BAF98628.1 putative_P450 BGC0000651.5 terpene 33.0 91.2 150.0 5.17e-41
AJI44171.1 cytochrome_P450_hydroxylase BGC0001193.5 NRPS:Type I 33.0 94.2 149.0 1.11e-40
ctg1_orf38 BGC0000096.5 PKS 33.0 93.2 149.0 1.55e-40
AEC04353.1 cytochrome_P450 BGC0000178.5 PKS:Trans-AT type I 29.0 98.5 149.0 2e-40
ABV83225.1 CppN BGC0000116.5 PKS 33.0 92.0 148.0 2.44e-40
AAP85338.1 cytochrome_P450 BGC0000233.5 PKS 33.0 87.9 147.0 8.45e-40
AAM94799.1 CalO2 BGC0000033.5 PKS 32.0 93.5 145.0 1.81e-39
QBL56197.1 cytochrome_P450_hydroxylase BGC0002376.2 PKS 29.0 92.5 145.0 2.27e-39
AAZ77695.1 ChlE2 BGC0000036.5 PKS:Type I+saccharide:oligosaccharide 32.0 93.5 145.0 2.56e-39
UPN68103.1 putative_cytochrome_P450 BGC0002672.2 PKS 32.0 94.5 145.0 2.56e-39
CAA76548.1 P450_monooxygenase BGC0000311.6 saccharide+NRPS:Type I 33.0 93.0 144.0 4.95e-39
QBF51800.1 cytochrome_P450 BGC0001856.4 PKS:Type I 31.0 97.7 144.0 5.64e-39
AFV52151.1 P450_monooxygenase BGC0000081.5 NRPS:Type I+PKS:Iterative type I 32.0 98.5 144.0 5.96e-39
ALU98532.1 cytochrome BGC0001397.5 NRPS:Type I+PKS 36.0 78.1 144.0 6.53e-39
UMP03499.1 NmvO BGC0002649.2 NRPS:Type I+PKS 30.0 96.0 144.0 6.77e-39
AAL06684.1 P450_hydroxylase BGC0000965.5 PKS:Iterative type I 36.0 78.1 144.0 7.14e-39
QGZ36660.1 cytochrome_P450 BGC0002082.3 NRPS:Type I+PKS 34.0 77.6 144.0 1.38e-38
AEW98132.1 cytochrome_P450-like_enzyme BGC0002642.2 other:other 32.0 95.2 143.0 1.38e-38
ABV98189.1 cytochrome_P450 BGC0000827.3 other:other 36.0 89.2 142.0 3.61e-38
QVV57681.1 6-deoxyerythronolide_B_hydroxylase BGC0002338.3 PKS 33.0 90.5 142.0 4.42e-38
NQE92416.1 cytochrome_P450 BGC0002120.3 ribosomal:RiPP:Lanthipeptide 33.0 87.2 141.0 6.35e-38
CBG70274.1 putative_monooxygenase BGC0002089.2 NRPS:Type I 31.0 102.0 140.0 1.25e-37
ANY10587.1 putative_cytochrome_P450_hydroxylase BGC0001773.4 PKS 32.0 97.5 139.0 3.27e-37
CAN89650.1 putative_cytochrome_P450_hydroxylase BGC0001070.5 NRPS:Type I+PKS:Type I 32.0 92.5 139.0 5.53e-37
BAJ16472.1 cytochrome_P450 BGC0000058.5 PKS 31.0 93.7 139.0 6.47e-37
AKQ20689.1 RebP-like_cytochrome_p450 BGC0001337.5 other:other 33.0 94.2 138.0 1.21e-36
RSO11549.1 cytochrome_P450 BGC0002637.3 NRPS:Type I 33.0 92.2 137.0 2.01e-36
AVL27080.1 cytochrome_P450 BGC0001485.4 other:other 30.0 98.5 136.0 7.39e-36
AGS77326.1 OxyC_monooxygenase BGC0001178.5 NRPS:Type I 31.0 92.0 135.0 1.57e-35
AEO12713.1 cytochrome_P450 BGC0001334.5 other:other 33.0 87.4 135.0 1.85e-35
ADR01067.1 NocB BGC0000609.3 ribosomal:RiPP:Thiopeptide 31.0 98.7 135.0 1.9e-35
AEI58869.1 p450_monooxygenase BGC0000455.6 saccharide+NRPS:Type I 31.0 92.5 135.0 2.06e-35
BAC55212.1 cytochrome_P450 BGC0000825.5 other:other 34.0 94.7 135.0 2.44e-35
QSE03589.1 Lcm6 BGC0002333.3 PKS 30.0 99.5 133.0 8.12e-35
AEA60655.1 cytochrome_P450 BGC0000892.4 other:other 31.0 93.2 132.0 1.25e-34
AJO72716.1 Cytochrome_P450_monooxygenase BGC0001381.5 PKS 34.0 99.0 132.0 1.52e-34
AXG22415.1 Cytochrome_P450 BGC0002024.3 PKS:Type I 30.0 92.7 132.0 1.94e-34
SCO70320.1 Cytochrome_P450 BGC0001433.5 PKS:Type I 31.0 93.7 132.0 2.72e-34
AEU17896.1 putative_P450_oxygenase BGC0001072.5 PKS:Type I+saccharide+other:aminocoumarin 30.0 86.7 130.0 1.2e-33
CBZ42153.1 putative_P450-like_enzyme BGC0001117.5 NRPS:Type I 32.0 89.4 129.0 1.64e-33
QIZ24101.1 cytochrome_P450_monooxygenase BGC0002540.3 PKS 29.0 97.2 129.0 2.23e-33
AHE14641.1 cytochrome_P450 BGC0001336.5 other:other 30.0 96.7 130.0 3.32e-33
ATY69582.1 cytochrome_P450_oxygenase BGC0001823.4 NRPS:Type I+PKS 30.0 95.5 127.0 9.82e-33
AEF32101.1 RebP-like_cytochrome_P450 BGC0001333.5 other:other 32.0 92.2 125.0 3.82e-32
AWH12925.1 StmP3 BGC0001784.5 PKS 29.0 91.7 125.0 3.82e-32
AWF71596.1 NascB BGC0001948.3 other:other 32.0 94.5 122.0 7.92e-31
AFK78079.1 XiaM BGC0000666.5 terpene:Sesquiterpene 29.0 95.2 122.0 9.1e-31
QIQ28633.1 Nbc37 BGC0002541.2 other:other 30.0 84.4 122.0 1.02e-30
BAC10677.1 putative_cytochrome_P450 BGC0000821.5 other:other 33.0 91.7 121.0 1.95e-30
AGY49583.1 PbtO BGC0001155.5 ribosomal:RiPP:Thiopeptide 32.0 98.0 120.0 2.15e-30
CCH63736.1 XiaJ_protein BGC0000665.5 terpene:Sesquiterpene+other:other 28.0 95.2 120.0 2.38e-30
ABP55168.1 cytochrome_P450 BGC0000150.4 NRPS:Type I+PKS:Enediyne type I 32.0 93.2 120.0 4.39e-30
WP_051422536.1 cytochrome_P450 BGC0000198.5 PKS:Type II+saccharide:hybrid/tailoring 31.0 91.7 119.0 1.63e-29
ABV83224.1 CppL BGC0000116.5 PKS 29.0 88.9 115.0 2.52e-28
ALV86869.1 Tlo23 BGC0001406.5 NRPS:Type I 30.0 94.5 114.0 1.04e-27
AKJ15833.1 cytochrome_P450 BGC0002735.2 PKS+NRPS:Type I 30.0 88.7 114.0 1.05e-27
WP_010875296.1 cytochrome_P450 BGC0001605.3 terpene 31.0 91.7 114.0 1.32e-27
AFV52184.1 acyl-CoA_synthetase/P450_monooxygenase BGC0000081.5 NRPS:Type I+PKS:Iterative type I 31.0 88.7 115.0 1.45e-27
QSV12651.1 AvmP BGC0002456.3 PKS+NRPS:Type I 28.0 95.0 113.0 1.7e-27
ADK32549.1 cytochrome_P450 BGC0000529.5 ribosomal:RiPP:Lanthipeptide 35.0 77.9 112.0 2.63e-27
ACN29722.1 cytochrome_P450 BGC0000814.3 other:other 33.0 96.5 111.0 8.71e-27
CBW54674.1 cytochrome_P450 BGC0000971.5 NRPS:Type I+PKS:Type I 33.0 69.6 110.0 1.26e-26
QBG38788.1 Atr27 BGC0001975.4 NRPS:Type I 28.0 94.0 110.0 1.4e-26
TMU97096.1 cytochrome_P450 BGC0002038.2 PKS 29.0 92.5 109.0 3.42e-26
QSE03594.1 Lcm10 BGC0002333.3 PKS 29.0 93.7 108.0 4.31e-26
BAX90002.1 Cytochrome_P450 BGC0001628.4 NRPS:Type I 31.0 91.2 108.0 1.03e-25
ABC84463.1 NigD BGC0000114.5 PKS:Type I 30.0 97.2 106.0 4.12e-25
QNH67553.1 Cip25 BGC0002108.3 NRPS:Type I 27.0 94.7 106.0 5.79e-25
EFG04605.1 Staurosporine_biosynthesis_Cytochrome_P450_StaN BGC0000826.5 other:other 28.0 99.5 104.0 2.92e-24
AAP42875.1 NanP BGC0000105.5 PKS 29.0 91.7 102.0 9.41e-24
ANS62964.1 putative_cytochrome_P450 BGC0001567.4 NRPS:Type I 29.0 90.7 100.0 1e-22
ABY83170.1 Azi32 BGC0000960.5 NRPS:Type I+PKS 29.0 89.4 100.0 1.06e-22
AAP69584.1 putative_cytochrome_P-450_monooxygenase BGC0000226.5 PKS 30.0 80.4 98.0 4.03e-22
ABP73648.1 SalD BGC0000145.5 NRPS:Type I+PKS 30.0 93.0 98.0 4.79e-22
ABP53495.1 cytochrome_P450 BGC0001041.4 NRPS:Type I+PKS 30.0 93.0 98.0 5.11e-22
QJU69507.1 LooP BGC0002460.3 other:other 31.0 69.1 94.0 1.78e-21
QEA08908.1 JenP1 BGC0002559.2 PKS 29.0 91.0 94.0 5.48e-21
BAE98161.1 putative_cytochrome_P450 BGC0000339.5 NRPS:Type I 28.0 90.2 94.0 6.13e-21
AEA30275.1 P450_monooxygenase BGC0000429.4 NRPS:Type I+PKS 27.0 87.2 93.0 2.58e-20
QYA95679.1 cytochrome_P450 BGC0002676.2 NRPS:Type I 27.0 87.2 93.0 2.58e-20
AET98913.1 putative_cytochrome_P450 BGC0000415.5 NRPS:Type I 28.0 74.9 90.0 1.8e-19
BAH04170.1 putative_cytochrome_P450 BGC0000450.5 NRPS:Type I 28.0 74.9 90.0 1.8e-19
AAL15601.1 SimI BGC0000270.5 PKS 28.0 88.9 90.0 2.01e-19
BAW27671.1 cytochrome_P450 BGC0001764.4 NRPS:Type I 28.0 76.4 89.0 3.57e-19
CAJ34365.1 quinaldate_3-hydroxylase BGC0000445.5 NRPS:Type I 28.0 75.4 88.0 1.12e-18
ACG60779.1 cytochrome_P450 BGC0001058.5 NRPS:Type I+PKS:Type I+saccharide:hybrid/tailoring 29.0 91.7 86.0 3.99e-18
BAI63285.1 putative_cytochrome_P450 BGC0000434.5 NRPS:Type I 27.0 75.4 84.0 2.86e-17
AEA29632.1 putative_cytochrom_P-450_hydroxylase BGC0000409.5 NRPS:Type I 29.0 86.9 80.0 4.08e-16