LOCUS       NZ_CP027562            10846 bp    DNA     circular CON 06-MAY-2024
DEFINITION  Stenotrophomonas maltophilia strain SJTH1 chromosome, complete
            genome.
ACCESSION   NZ_CP027562
VERSION     NZ_CP027562.1
KEYWORDS    RefSeq.
SOURCE      Stenotrophomonas maltophilia
  ORGANISM  Stenotrophomonas maltophilia
            Bacteria; Pseudomonadota; Gammaproteobacteria; Lysobacterales;
            Lysobacteraceae; Stenotrophomonas; Stenotrophomonas maltophilia
            group.
REFERENCE   1  (bases 1 to 4932325)
  AUTHORS   Xiong,W., Yin,C., Wang,P. and Liang,R.
  TITLE     Isolation and characterization of a novel 17beta-estradiol degrading
            bacteria Stenotrophomonas maltophilia SJTH1 from wastewater
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4932325)
  AUTHORS   Xiong,W., Yin,C., Wang,P. and Liang,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-MAR-2018) State Key Laboratory of Microbial
            Metabolism, School of Life Sciences and Biotechnology, Shanghai
            Jiaotong University, 800 Dongchuan Road, Shanghai 201100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 27-OCT-2017
            Assembly Method                   :: A5-miseq v. v20150522
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 188.0x
            Sequencing Technology             :: Illumina MiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003006435.1-RS_2024_05_05
            Annotation Date                   :: 05/05/2024 23:26:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,553
            CDSs (total)                      :: 4,465
            Genes (coding)                    :: 4,404
            CDSs (with protein)               :: 4,404
            Genes (RNA)                       :: 88
            rRNAs                             :: 4, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 61
            CDSs (without protein)            :: 61
            Pseudo Genes (ambiguous residues) :: 0 of 61
            Pseudo Genes (frameshifted)       :: 26 of 61
            Pseudo Genes (incomplete)         :: 36 of 61
            Pseudo Genes (internal stop)      :: 8 of 61
            Pseudo Genes (multiple problems)  :: 7 of 61
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:27:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1211047
            Orig. end                         :: 1221893
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP027562.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10846
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10846
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10846
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5846](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5846)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    195..208
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            559..1695
                     /locus_tag="C6Y55_RS05645"
                     /old_locus_tag="C6Y55_05645"
     CDS             559..1695
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004147841.1"
                     /locus_tag="C6Y55_RS05645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05645"
                     /product="metallophosphoesterase"
                     /protein_id="WP_106467354.1"
                     /sec_met_domain="Metallophos_2 (E-value: 6.5e-09, bitscore:
                     34.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAVLSTIGFLMGLYVAWRLFWPLRMRIWMKVVLSLLLVGVAVQL
                     RIVAMFWGTMASPEIPKLAIATLATGSTAVLLLALVMLVLDAGLLLSHLLRWPRTVSAL
                     RAPKLRPMAGLLALLVSGYGVSQGMAVPKPRQIEVSIAGLPAAFDGYRVLQLTDIHASR
                     LLTGDWVRKVVDESNALTPDLIVITGDLIDGSVEARRDDARPLADLHAPDGVIAITGNH
                     EYYAQYQAWMQAFRALHMQVLENSHLQVRRGDAALTIAGVTDPVAARYGLPLPDLGAAL
                     AGADPTAPVILLDHRPRNAREAAARGVKLQLSGHTHGGQIIGMDQMVKRANGGYVSGRY
                     DVDGMTLYVSNGAGLWAGFPARIGVPSEITLVTLRRAP"
     gene            1766..2170
                     /locus_tag="C6Y55_RS05650"
                     /old_locus_tag="C6Y55_05650"
     CDS             1766..2170
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012510383.1"
                     /locus_tag="C6Y55_RS05650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05650"
                     /product="hypothetical protein"
                     /protein_id="WP_106467355.1"
                     /transl_table=11
                     /translation="MAHPRAPMERLIRANADDINRLRKVVRDTAGARWRGPEEQARHAA
                     ACAEFHLHYARLAFPGGYANALKRLAEHDPDTLDVALTFLEVRPYFFRSGYMWKTLLKR
                     VQRVAMGTKQHARLQEILDAYAAYRATREG"
     misc_feature    complement(1788..1802)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.77"
                     /tool="antismash"
     gene            complement(2176..3420)
                     /locus_tag="C6Y55_RS05655"
                     /old_locus_tag="C6Y55_05655"
                     /pseudo=""
     CDS             complement(2176..3420)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611813.1"
                     /locus_tag="C6Y55_RS05655"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05655"
                     /product="IS4 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRASQVLQKCLPNSLSAMHVLRMRALLSAVQALIVGRRLTLTDIA
                     RAWPGAERVRAPLKAFDRLLGNRHLHGERGAIEADMARWLLRGPQPVHPHRLV"
     misc_feature    complement(3511..3526)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.27"
                     /tool="antismash"
     misc_feature    3512..3528
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.86"
                     /tool="antismash"
     gene            complement(3582..4220)
                     /locus_tag="C6Y55_RS05660"
                     /old_locus_tag="C6Y55_05660"
     CDS             complement(3582..4220)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005408497.1"
                     /locus_tag="C6Y55_RS05660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05660"
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="WP_106467356.1"
                     /transl_table=11
                     /translation="MTVSNTSFLHGWRLFVAISLVLIAFALTAFALHPDAAEGSRAAIR
                     VTARTSFLLFLTVFTASSFASLLPGPFTRFLLRERRIIGLSFAFSHLLHAIAITSFGIL
                     NPAFWPARSALTNLPGTVGYIAILALAITSHRGLARRIGPTAWRRLHVTGMWIIAAVFT
                     YSYFKRVPGNFWYAVPSALLFTAFVVRWIAKRVQALRRSTHARPPLRAA"
     gene            complement(4223..5008)
                     /locus_tag="C6Y55_RS05665"
                     /old_locus_tag="C6Y55_05665"
     CDS             complement(4223..5008)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019659351.1"
                     /locus_tag="C6Y55_RS05665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05665"
                     /product="putative DNA-binding domain-containing protein"
                     /protein_id="WP_106467357.1"
                     /transl_table=11
                     /translation="MAESLATLQRRWADHVRDPAMAAPDGVEARRLAVYRRLCIDSLDT
                     LLAGTLPRLQHQLGTPRWRDTMEHYYASHTCRTPLFPQIAGEFAAWLAMQDALALPAWA
                     AELAHYESTQQSLHIEARGAGRLLHRVPVDSDVLAVSPLVRVLGYRWPVHVDEMLEPMP
                     DAAPTLLLMRRMPEFSLRVEELAPLAYAVLLAFGDDGTRVDDVLQTVAETHGVAPDELR
                     AACIPVLRDLCAAAVLVASTDPRERRPAAGTTPSPFFEA"
     gene            complement(5001..5846)
                     /locus_tag="C6Y55_RS05670"
                     /old_locus_tag="C6Y55_05670"
     CDS             complement(5001..5846)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014646321.1"
                     /locus_tag="C6Y55_RS05670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05670"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_106467358.1"
                     /sec_met_domain="DUF692 (E-value: 7.5e-119, bitscore:
                     393.9, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLPLPSNAAGLGLRRGLIDELLAMPAGAIDFLEVAPDNWIGVGG
                     AHGAALRRLSERHPLTCHGLSLSLGGPDPLDRTLLAQTRDFLDLHQVRLYSEHLSYCAA
                     GGHVYDLLPLPFTAEAVHHVAGRITQVQDLLGRRIAVENISYYAVPGADMSEIDFINAV
                     LTEADCDLLLDVNNVFVNACNNGYDAFDFLAHVPSHRVASLHVAGHFDEDDGFKIDTHG
                     APVKGVVWALLREAYARVGVRPTLLERDFNFPPLAELLAEVAQIRQAQVEARWPEVAHG
                     "
     gene            complement(5903..6379)
                     /locus_tag="C6Y55_RS05675"
                     /old_locus_tag="C6Y55_05675"
     CDS             complement(5903..6379)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005412584.1"
                     /locus_tag="C6Y55_RS05675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05675"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_106467359.1"
                     /transl_table=11
                     /translation="MSVSTKNTPSSRLPRVGAIGIALAGGLLLAGQAAAIQPLAISAVA
                     MSAAAEGKCGEGKCGANKATTGKPAGKARVAEGQCGEGKCGDASFARTDRDHDGKVSRA
                     EFNAVAAKRAAEFDRIDTDHDGYISEQEAHDYLRSVYTVNGKPMPKGLFSRVAD"
     gene            complement(6468..7112)
                     /locus_tag="C6Y55_RS05680"
                     /old_locus_tag="C6Y55_05680"
     CDS             complement(6468..7112)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012479418.1"
                     /locus_tag="C6Y55_RS05680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05680"
                     /product="DoxX family protein"
                     /protein_id="WP_106467360.1"
                     /transl_table=11
                     /translation="MISTASSVYTPRLDAVGRWLSPVALRILLAWEFFESGREKLGGQN
                     WFADLEGRFPFPFSTLPASLNWQLATWLELVGAVMLLLGLATRAVAYVFWVLTVVAIAA
                     VHWPDQWNGLGELWQGYAITDQGYGNFKLPLLFLAMLLPLVLNGGGALSVDRLLAGSPH
                     APAGNDGLGWGVSLIALLLPVAALLPGIGFGGALLGGVLLLGHLLRRRRSA"
     gene            7455..8249
                     /locus_tag="C6Y55_RS05685"
                     /old_locus_tag="C6Y55_05685"
     CDS             7455..8249
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005408502.1"
                     /locus_tag="C6Y55_RS05685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05685"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_106467361.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.4e-15, bitscore:
                     55.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRSSLLAAALAFAGAAAPAFATQADTAAPPTVILVHGAFADGSS
                     WSKVIRTLHDWKLPAVAVQNPLTSLADDVATTRRAIAAAPGKVVLVGHSWGGTVITEAG
                     DDPKVQALVYVAAFAPDAGQSSAQQGEDFPVGPGLARLQERDGYLTLPADAIAQDFAPD
                     VTKKSAALLYSTQVPLKASALGEVVNVAAWRSKPSWYVLSRDDRMLSPQLQAATARRIG
                     AQLQSIGSSHVSLLSHPAQVADSILEAAGVKPAELPLAEQGG"
     gene            8253..8798
                     /locus_tag="C6Y55_RS05690"
                     /old_locus_tag="C6Y55_05690"
     CDS             8253..8798
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1241: lipoprotein
                     dsbF"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005415663.1"
                     /locus_tag="C6Y55_RS05690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05690"
                     /product="redoxin family protein"
                     /protein_id="WP_106467362.1"
                     /transl_table=11
                     /translation="MAALRGYALPLLLGLLGGAALLLAWPGAEAGTQPLDAAPKAGFGG
                     GGPWHNSPPMTLKQLRGQVVLVEFWTYTCSNCLNVAPYVHQWHARYASQGLQVIGVHTP
                     EFAYEGLPGNVSRAITRLDITWPVVQDNQYRIWNAWGNRFWPALYLLDRQGRVVYRHYG
                     EGDYARTESEIQRLLASP"
     gene            8856..9596
                     /locus_tag="C6Y55_RS05695"
                     /old_locus_tag="C6Y55_05695"
     CDS             8856..9596
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019659345.1"
                     /locus_tag="C6Y55_RS05695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6Y55_05695"
                     /product="response regulator transcription factor"
                     /protein_id="WP_100471599.1"
                     /transl_table=11
                     /translation="MNPVPHILVVDDDSEIRQMLADYLQRNGLRVSQADGGRAMRALMD
                     THAVDLVVLDVMMPGEDGLSLCRNLRAGKHRAVPVVLLTARDDETDRIIGLEMGADDYV
                     TKPFSSRELLARINAVIRRTQMLPPNLQVSEAGRQLAFGAWRLDTTARHLLDAQDTAYP
                     LSGAEFRLLRVFLDHANRVLSRDQLLSLTQGRDAELFDRSIDLLVSRVRQRLGDDAREP
                     TYIKTVRSEGYVFSVPVQLLGPDE"
     misc_feature    complement(10392..10406)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
ORIGIN
        1 cctccaccaa ggctcgagcc aaggcttcgt gatagatacc tgtagcctcc atgcctaccg
       61 ccgcgttcgg tgcatgcttg gcgcgccacg caagaagctc atcaaagccc tttggcgtat
      121 tggggagttt ggccttggtt cgatacttgc tgccagatag tggcacggcg atatcaaagg
      181 tcgccttggc tgcgtcgatg ccgataaatt gcatgatttg gctccagctt gaacttacga
      241 tcgtgatcgg aagccgccag acttgccctt gtgagtacag gctctcaccc catggtgggc
      301 ctaagatacc gttcaagttc caaggcggtg tcaggccgcc gacgcgctga atctactttg
      361 caagctcgaa ggcttaagag ccgaggcagc gtcatcggag cctcccgggt caccggggga
      421 ttgtgcctga tcagggcacc atccaagaca caagagccga gcccatgctc ggctgcattt
      481 tgagaagccg agcgcaggct cggctctaca caacacctcc cgcaaccgtc accatggcgg
      541 gcccgttttc cttcccggat ggttgcagtg ctgagtacga tcggttttct gatgggcctg
      601 tatgtggcct ggcgcctgtt ctggccactg cgcatgcgca tctggatgaa ggtcgtgctg
      661 tcgctgctgc tggtgggcgt tgccgtgcag ctgcgcatcg tagccatgtt ctggggcacg
      721 atggcctcgc cggagatacc gaagctggcc atcgccacgc tggccaccgg ctccaccgcc
      781 gtgttgctgc tggcgctggt gatgctggtg ctggacgccg gcctgctgct gtcgcacctg
      841 ctgcgctggc cgcgtactgt atcggccctg cgcgcgccga agctgcggcc gatggcaggt
      901 ctgctggccc tgctcgtgag tggttatggt gtcagccagg gtatggccgt ccccaagccc
      961 cggcagatcg aggtgagcat cgccggcttg ccggccgcgt tcgatggcta tcgcgtgctg
     1021 caactgaccg acatccatgc cagccgcctg ctgaccggcg actgggtgcg caaagtggtg
     1081 gatgagagca acgcactgac gccggacctg atcgtgatca ccggtgatct gatcgacggc
     1141 agtgtcgagg cgcgtcgcga cgacgcgcgg ccgctggccg atctgcatgc accggacggc
     1201 gtcatcgcca tcaccggcaa ccacgagtac tacgcgcagt accaggcgtg gatgcaggcg
     1261 ttccgcgcgc tgcacatgca ggtgctggag aacagccacc tgcaggtgcg gcgcggtgat
     1321 gcggcgctga ccatcgccgg cgtcaccgat ccggtggccg cacgctacgg cctgccgctg
     1381 ccggacctgg gtgccgcgct ggccggtgcc gatccgacgg cacccgtgat cctgcttgat
     1441 catcgcccgc gcaatgcacg cgaagcggcc gcgcgtggcg tgaagctgca attgtccggg
     1501 catacccacg gcgggcagat catcggcatg gaccagatgg tgaagcgggc caacggtggc
     1561 tatgtctccg gtcgctacga cgtggatggc atgaccctgt acgtgagcaa tggtgcaggc
     1621 ctctgggcgg gtttcccggc gcgcatcggc gtgccgtcgg agatcaccct ggtgacgctg
     1681 cgccgcgcgc cgtgacccgg aagtgggggc agatcccttc ccttttggga aggggatctg
     1741 accgctggca aatctggaaa gacccatggc ccatccccgc gccccgatgg aacgcctgat
     1801 ccgcgccaat gccgatgaca tcaaccggct ccgcaaggtg gtccgcgata ccgcgggagc
     1861 acgttggcgt gggccggagg agcaggcacg gcacgctgcg gcctgtgcgg aattccacct
     1921 gcactacgcg cggctggcgt ttccgggcgg ctatgccaac gcgttgaaac ggctggccga
     1981 acatgatcca gatacgctgg atgtcgcgct gaccttcctt gaagtgcggc cgtatttctt
     2041 ccggtccgga tacatgtgga agacgttgct gaagcgcgtg caacgggtag ccatggggac
     2101 gaagcaacac gcgcggctgc aggagatcct cgatgcctac gctgcctatc gcgccacacg
     2161 tgaaggctga tggggtcaga tcctgaggta tccccacgtt ttcatggcag caacgtcatt
     2221 tggtgcaagg ccttctccgg gggcgagcgc agaagatcaa gccaccgtgc cggtggccct
     2281 aggggccagc ctctgactag tgcctcgcgc ccaacgcgtg gggtggaata gcgcttgcgg
     2341 gtgcttttgc tgggccaaag ccagtgggcg atgtctgccg cttcgcacac caagccggcc
     2401 agccagctga cgaagggtgg ccagcgtgct gatcaggagc aggatctgca gcctgggccc
     2461 ttgccgggtc agactgtctt ccagggcatg cccgtagcgg tgtgattgag atctcgaaag
     2521 gccagttcga tctgcatccg gcgggcatag aggttaacca actgtcgggc gctggcctgg
     2581 ctcaattcgg gcgcggccac gataagccaa ggctcctcgc tcacgagcag cagccttcag
     2641 gctcaccgcc gaacgagagg cctgctgtgg agtacggcgg gtggattttt tgcggccctt
     2701 acgcgttttg gaacacacca ccacgcggca ggccagcggc gagctgcggt tgaccagcgc
     2761 tggcgggagc tcgcgtggca cggtcctggc tctggcgtgc agggtgcggc tgtcatgcca
     2821 gtgttccggg cagttggggg cctcctgaag tttgatgcgc gttgctccac gcagacgccc
     2881 cacccagtgc cagcccagcg caggaaaccg cgcgaaacca aggggtccgg aacccagcat
     2941 cggtcaccag aatcggagtt accccttctg gaatgagctt gcgcaattgc tgcagaaaat
     3001 gcctctcggc ctcggcggag ccttgttctt tcccgcgaac aatcgtgtcc agcagcgtca
     3061 gcgtgcggcc gcccacggga accgccgcgc gaagcaaagc accagctttt gtccggcttc
     3121 aagtcagacc agtcgatgag gatggaccgg ctgtgggcca cgtagcagcc agcgagccat
     3181 gtcggcctca atggcaccgc gttcgccatg tagatgccga ttccccaaca ggcgatcaaa
     3241 cgccttgagc ggagctcgta cacgctcggc cccaggccac gctcgagcga tatcggtcaa
     3301 ggtcaaccgt cgcccaacga tcagcgcttg caccgcgctg agaagggccc gcatgcgcag
     3361 gacatgcatg gccgatagtg agttgggcaa gcacttctgc aatacttggc tggcgcgcat
     3421 gaccgcattc ttcttttggt ttagtcacct tgaaggctgc ggcatgcgcg cacttgtttc
     3481 cagagcctga tgcgtaagcc attgctctgt ctgaagaaaa cgtggggata cctcagggtc
     3541 agatcccttc gcctttggca aaggggtctg accccggccc gtcaggccgc ccgcagcggc
     3601 ggccgcgcat gcgtgcttcg gcgcagcgcc tgcacccgct tggcgatcca gcgcaccacg
     3661 aaggcggtga acagcagcgc cgatggcacc gcataccaga agttgcccgg cacgcgcttg
     3721 aagtacgagt aggtgaacac cgctgcgatg atccacatgc cggtcacgtg caggcgacgc
     3781 caggccgtgg gtccgatgcg ccgggcgagc ccccggtgcg aggtgatggc cagcgccagg
     3841 atggcgatgt aacccaccgt gcccgggagg ttggtcagcg ctgagcgtgc tggccagaac
     3901 gccgggttga ggatgccgaa actggtgatg gcgattgcgt gcagcaggtg cgagaacgcg
     3961 aaggacaggc cgatgatgcg ccgttcgcgc agcaggaaac gagtgaacgg gccgggcagc
     4021 aggctggcga acgacgatgc cgtgaacacc gtcaggaaca gcaggaacga tgtgcgtgca
     4081 gtgacccgga tcgccgcccg gctgccttcg gctgcatcgg gatgcagggc gaaggcggtc
     4141 agtgcgaacg cgatcaggac caagctgatg gctacgaaca ggcgccagcc gtgcaggaag
     4201 gacgtgttgg aaacggtcat ggtcaggcct cgaagaatgg agagggggta gtgccggccg
     4261 ctggccggcg ttcccgggga tcagtcgacg caaccagaac ggctgccgcg cagaggtcgc
     4321 gcagcactgg aatgcaggcc gcacgcagtt catccggcgc gacaccatgt gtttcagcca
     4381 cggtctgcaa tacgtcatcc acacgtgtgc cgtcatcgcc gaaggccaac agcaccgcat
     4441 aggccagcgg ggccagttcc tcgacacgca gactgaattc aggcatgcgg cgcatcagca
     4501 gcagcgtggg agctgcatcc ggcatcggtt ccagcatctc gtccacatgt accggccacc
     4561 ggtagccaag cacccgcacc agcggcgaaa ccgccagcac atcactgtcc accggaacgc
     4621 ggtgcagcaa acgcccggcg ccacgggctt caatgtgcag cgactgctgc gtgctctcgt
     4681 agtgcgccag ttccgctgcc caggccggca gtgccagcgc gtcctgcatc gccagccatg
     4741 ctgcgaattc gccggcgatc tgtgggaaca acggggtgcg acaggtgtgg ctggcatagt
     4801 agtgctccat tgtgtcgcgc cagcgcggcg tgcccaactg gtgttgcagg cgtggcaggg
     4861 tgccagccag cagggtgtcc aggctgtcga tgcacaggcg gcggtatacc gccagcctgc
     4921 gcgcctcgac gccatcgggt gcggccattg cagggtcgcg cacatggtcg gcccagcgcc
     4981 gttgcagggt agccagcgac tcagccatgg gccacctcgg gccaacgtgc ctcgacctgc
     5041 gcctggcgga tctgtgcgac ctcggccagc aactctgcca acggcgggaa gttgaagtcg
     5101 cgttcgagca gcgtggggcg cacgcccacc cgcgcatagg cctcgcgcaa cagcgcccag
     5161 accacacctt tcaccggcgc accgtgggta tcgatcttga agccatcgtc ttcatcgaag
     5221 tggcccgcca cgtgcagcga ggcgacacgg tgggacggca cgtgggccag gaaatcaaag
     5281 gcgtcgtaac cgttgttaca ggcgttgacg aagacgttat tgacgtccag cagcaggtcg
     5341 cagtcggctt cggtgagcac ggcgttgatg aagtcgatct cgctcatgtc cgcgccggga
     5401 acggcgtagt aggagatgtt ctccacggcg atgcgtcggc ccagcaggtc ctgcacctgg
     5461 gtgatgcgac cggcgacatg gtgtacggcc tcggcggtaa acggcagcgg cagcaggtcg
     5521 tagacatggc caccggcggc gcagtagctc aggtgttcgc tgtacaaccg cacctggtgc
     5581 aggtcgagga agtcgcgcgt ctgtgccagc agggtgcggt ccagcggatc aggaccgccc
     5641 agcgacagcg acaggccatg gcaggtcagg gggtgacgtt cgctcaacct gcgcagcgct
     5701 gcaccgtgtg caccaccgac gccgatccag ttgtcgggcg caacttcgag gaagtcgatg
     5761 gcaccggccg gcatggccag cagttcgtca atcaggccac ggcgcaggcc aagaccggcg
     5821 gcattggaag gcaggggcag ggacatggcg gatgctccag ggagagggcg ccgcctcgga
     5881 ggcggcgccg gttgaacgtc gatcaatcgg caacgcggga gaacagaccc ttcggcatcg
     5941 gcttgccatt gacggtgtag acgctgcgca ggtagtcgtg cgcttcctgc tcgctgatgt
     6001 agccgtcgtg gtcggtgtcg atgcggtcga actcggcggc acgcttggca gccacggcat
     6061 tgaactcggc acgcgagacc ttgccgtcgt ggtcacggtc ggtgcgggca aacgaggcgt
     6121 cgccgcactt gccttcgccg cactggccct cggccaccct ggccttgccg gcgggcttgc
     6181 cggtggtggc cttgttggcc ccgcacttgc cttcaccgca cttgccttcg gcggcagcgc
     6241 tcatggccac cgcgctgatc gccagcggct ggatcgccgc ggcctggccg gccagcagca
     6301 ggccaccggc cagggcgatg ccgatggcac cgacgcgcgg caggcgggag gagggggtgt
     6361 tcttggtcga tacggacatg atggtgactc cttgggaaag cacgcggggc gtgcgggatg
     6421 gacgccgccg aacaggcggc ggaaagaggc gcgtggtaaa aggcagatca ggcgctgcgg
     6481 cgacgacgca gcagatggcc cagcagcagc acaccgccga gcagggcacc gccgaagccg
     6541 atgccgggca gcagcgcggc aaccggcagc agcagggcga tcaggctgac gccccagccc
     6601 aggccgtcgt tgccggcggg ggcatgcggc gagccggcca gcagccggtc gacgctgagt
     6661 gcgccaccac cgttgaggac cagcggcagc agcatggcca ggaacaacag cggcagcttg
     6721 aagttgccgt agccctggtc ggtgatcgca tagccctgcc agagttcgcc caggccgttc
     6781 cattggtcgg gccagtgcac ggcggcgatg gcgaccacgg tcaacaccca gaagacgtag
     6841 gccaccgcgc gcgtggccag gccgagcagc agcatcaccg cgcccaccag ttccagccag
     6901 gtggccagct gccagttcag tgatgcgggc agggtggaga acgggaacgg gaagcgacct
     6961 tccaggtcgg cgaaccagtt ctggccaccc agcttttcgc gaccggattc aaagaactcc
     7021 caggccagca ggatgcgcaa cgccacgggc gagagccagc gaccgacggc gtccaggcgg
     7081 ggggtataca cggaagaggc ggtgctgatc atggtggtgt cctgcgggcc agtggtcgat
     7141 ggacgccatt tcaggcggcg caggtatcgg caacgtgtac cgttgcccgg ggttttgtca
     7201 gcgactgtgg ccgcggccgg ggtttcctac agtcagatac aaagacgatg cgttgatgca
     7261 catcggggcg ttgcgcgccc gcgcgcgggg aacgatctcc acccggtagt gcctggccgg
     7321 gcgcggcacc cgaatgtatc ccactgtaga aacacgcctg cgccctacag tccggtacaa
     7381 ctccgtgccg cggagaaaca gcgccgatac accggcaggc ggaaatggcc actcccaacc
     7441 ccggagtgcc acccatgatc cgtagctcgt tgcttgctgc cgctctcgcc tttgccggcg
     7501 ccgctgctcc cgccttcgct acccaggccg ataccgctgc accgcccacc gtcatcctgg
     7561 tgcacggcgc cttcgccgat ggctccagct ggagcaaggt catccgcacc ctgcatgact
     7621 ggaagctgcc ggcggtggcc gtacagaatc cgctcacctc gttggccgac gacgtcgcca
     7681 ccacccgtcg cgccattgcc gccgcaccgg gcaaggtcgt gttggtcggc cacagctggg
     7741 gcggcacggt catcaccgaa gcgggcgatg acccgaaggt gcaggcgctg gtgtacgtgg
     7801 ccgcgttcgc accggatgcc gggcagtcat cggcacagca gggcgaggac ttcccggtcg
     7861 gtccgggcct ggcccgactg caggagaggg atggctacct gaccttgccg gccgatgcca
     7921 tcgcccagga cttcgcgccg gacgtgacga aaaaatcggc cgcactgctg tacagcacgc
     7981 aggtcccgtt gaaggccagc gcgttgggcg aggtggtcaa cgttgcggcg tggcgcagca
     8041 agccgagctg gtacgtgctc agccgtgacg accgcatgct gtcgccgcag ctgcaggccg
     8101 ccaccgcacg ccgcatcggc gcacagctgc agtcgatcgg cagcagccac gtgtcgctgc
     8161 tttcgcatcc ggcgcaggtg gccgacagca tcctggaggc ggcaggcgtg aagccggccg
     8221 aactgccgct ggccgagcag ggcggctgag cgatggccgc actgcgaggg tatgcactgc
     8281 ccctgctgct gggcctgctg ggtggagcgg cgttgctgct ggcctggccc ggcgccgagg
     8341 ccggcacgca gccactcgac gcagcaccga aggcggggtt cggcggtggc gggccctggc
     8401 acaacagccc accgatgaca ctgaagcagt tgcgggggca ggtggtactg gtcgagttct
     8461 ggacctacac ctgcagcaac tgcctcaatg tggcgccgta tgtccaccag tggcatgcac
     8521 gctacgcgtc gcagggcctg caggtgatcg gcgtgcatac gccggagttc gcctatgaag
     8581 ggctgcccgg caacgtgagc agggccatca cacggttgga tatcacctgg ccggtggtgc
     8641 aggacaacca gtaccggatc tggaatgcct ggggcaaccg cttctggccg gcactgtacc
     8701 tgctcgaccg gcaggggcgg gtggtctatc gccattacgg cgagggcgac tacgcacgta
     8761 ccgaaagcga gatccagcgc ctgctggcca gcccctgagc cgcgctacca tggcggcgtc
     8821 gcgcggcgct gccccctgcc ttcatcgaga acgcaatgaa tcctgtaccg cacatccttg
     8881 tcgtggacga tgacagtgag atccgccaga tgctggccga ctacctgcaa cgcaacggcc
     8941 tgcgcgtgag ccaggccgac ggcggccggg ccatgcgcgc gctgatggac acccacgcgg
     9001 tggatctggt ggtgctggac gtgatgatgc cgggcgagga cggcctgagc ctgtgccgca
     9061 acctgcgcgc cggcaagcat cgtgcggtgc cggtggtgct gctgaccgcc cgcgacgacg
     9121 agaccgatcg catcatcggc ctggaaatgg gcgccgacga ttacgtgacc aagccctttt
     9181 cctcgcgcga actgctggca cgcatcaatg cagtgatacg tcgcacacag atgctgccgc
     9241 cgaacctgca ggtgagcgaa gccggccgcc aactggcttt cggtgcctgg cgcctggata
     9301 ccaccgcgcg ccatctgctg gatgcacagg acaccgcgta tccgctcagt ggtgccgagt
     9361 tccgcctgtt gcgcgtgttc ctcgatcacg ccaatcgcgt gctcagccgt gaccagctgc
     9421 tcagcctcac ccagggccgc gatgccgaac tgttcgaccg ctcgatcgac ctgctggtca
     9481 gccgcgtgcg gcagcgcctg ggtgacgacg cacgcgagcc gacctacatc aagaccgtgc
     9541 gcagcgaagg ctatgtgttc agcgtgccgg tgcagttgct ggggccggac gaatgaacac
     9601 cggcgcgcgc cgtccacgct ggccgcgcac gctgtcggcg cggctgctgc tggtgctgct
     9661 gggcggactg gcgctggccc acgcgctgtc cttcggcctg ctgttcttcg aacgctacca
     9721 atccacccgc agcatgatgc tgcgcaacct ggatgaggat gtggcagtga gtgtcgcgct
     9781 gctggagcac ctgcccgcag agcagcgcga tgcctgggtg ccgcggctgg agcggcgcac
     9841 ctaccgttac ctgctgcgcc cggctacggc ggggcccggg ctgcagaccg atcgtgcacg
     9901 ccaggtcacc gcgatcatcg acgacagcct gcagcaccgc tatccgctgc aggcgcgcca
     9961 ggtagctcgt ttgccggagc gcttcgaggt cgaactgcgc ctgcacgacg gcacgccgtt
    10021 gaccattgaa gtcaccccgt cgggcctgcc gctggcacgc tggctgcccg ccgtactgct
    10081 tgtgcagctg gcgctgctgc tggtgtgcgc atggctggca gtgcgcctgg ccatgcgccc
    10141 gttgcagcag ctgtcgcatg cggtggaaca gctgcagccg ggcaaggacg ggccggtact
    10201 gcctgaagat gggcctgcgg aagtaggcgg tgcggcggcc gcactcaacg cgctgcaggc
    10261 acgcattcgt ggccatgtca gcgagcgcct gcagatcctc gcagcgatct cgcacgatct
    10321 gcagaccccc atcacgcgca tgaagcttcg ggtggagacc ctgcctgaag acagcaccca
    10381 gcagcggctg ctggccgacc tcgaccacct tgggcaactg gtgcgcgaag gcgtggccta
    10441 tgcgcgcagc agccacgtcg ccagtggcgc gccagtggcg atggacctgg gtgcgttcct
    10501 ggccagcgtg gtcggcgact acgaggacat gggcaagccg gtcagtggcg gtgcgcccgc
    10561 tggactgatc gtgcagacct ggccgcagcc gctgcgacgg gtggtcggca acctggtcga
    10621 caacgcagtg cgctacgccg gtgccgccga gatcgaagcc ggccgcgatg aggctggcag
    10681 gatatggatc cgtatttccg accgtggccc gggtatcccg gagaaccagc tgcaggcggt
    10741 gctggcaccg ttccatcggc tggaaagctc gcgcaaccgc gataccggcg gcaccggcct
    10801 gggcctggcc atcgcggtgc agctggcgca gtcgctgggc ggctca
//
