LOCUS       NZ_PVTF01000023        10816 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Umezawaea tangerina strain DSM 44720 Ga0180964_123, whole genome
            shotgun sequence.
ACCESSION   NZ_PVTF01000023
VERSION     NZ_PVTF01000023.1
KEYWORDS    WGS; RefSeq.
SOURCE      Umezawaea tangerina
  ORGANISM  Umezawaea tangerina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Umezawaea.
REFERENCE   1  (bases 1 to 142802)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 142802)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Expected Final Version            :: No
            Genome Coverage                   :: 86.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003002815.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:47:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,483
            CDSs (total)                      :: 9,418
            Genes (coding)                    :: 9,322
            CDSs (with protein)               :: 9,322
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 20 of 97
            Pseudo Genes (incomplete)         :: 83 of 97
            Pseudo Genes (internal stop)      :: 2 of 97
            Pseudo Genes (multiple problems)  :: 8 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:41:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 86759
            Orig. end                         :: 97575
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVTF01000023.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10816
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10816
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10816
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5816](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5816
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(256..906)
                     /locus_tag="CLV43_RS44825"
                     /old_locus_tag="CLV43_12387"
     CDS             complement(256..906)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099310.1"
                     /locus_tag="CLV43_RS44825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12387"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_106196654.1"
                     /transl_table=11
                     /translation="MTPPLHLSLAGQTVDVLRELVLTGEIPPGERVNEVELAHRLGISR
                     GPLREAIRHLSSEGLLVLVPNKGAHVPKADADEVRALFELRSALECAAAELAASRRTDG
                     DVERLREVCAESRNTHRTGARFPYRLDLAFHQALLDAARSPRIAEQVRLVQQRVVLLRA
                     GLKDDPPHQQASLDDHDALVAAIAAGDTHQANRAMRRHLSRVRAQMLTSLDSA"
     misc_feature    complement(944..962)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.81"
                     /tool="antismash"
     misc_feature    947..965
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.52"
                     /tool="antismash"
     gene            983..1936
                     /locus_tag="CLV43_RS44830"
                     /old_locus_tag="CLV43_12388"
     CDS             983..1936
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032563.1"
                     /locus_tag="CLV43_RS44830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12388"
                     /product="asparaginase"
                     /protein_id="WP_106196655.1"
                     /transl_table=11
                     /translation="MVHEVVAEVWRGEFLESVHHGTVVALGADGRAVLSVGRPELVAFP
                     RSSNKPVQGLAMVRHGLDLDGELLALACASHSGEDFHVEGVRRILAKAGLGFDALQCTP
                     DLPIGEAALAAHLKAGRGRAPEYMNCSGKHAAMLLTCVRNGWSTDDYLAFEHPLQVAIR
                     ATLEELAGERVGAVGVDGCGAPLFGISLNGLARAFGRMAGARAGTEEHRVAAAMNAHPE
                     HVGGTGRDVTALMRALPGAMAKDGAEGVYAIGLPDGSAVALKIADGSSRARAVVMVAAL
                     RALGVDVGSLTTLATVPVLGHGREVGAVRPALALAG"
     gene            1957..2271
                     /locus_tag="CLV43_RS44835"
                     /old_locus_tag="CLV43_12389"
     CDS             1957..2271
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800404.1"
                     /locus_tag="CLV43_RS44835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12389"
                     /product="hypothetical protein"
                     /protein_id="WP_106196656.1"
                     /transl_table=11
                     /translation="MATFPGAGRPEDGPEKRFADDLIGLDPADPEAKAFAEHLDRMERE
                     RPGYTVEGYLAGVADFADSANRASGEQRLVAVLVVGLILLGVLISVWFGLGEIISVLFG
                     "
     gene            2326..2754
                     /gene="msrB"
                     /locus_tag="CLV43_RS44840"
                     /old_locus_tag="CLV43_12390"
     CDS             2326..2754
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009153937.1"
                     /locus_tag="CLV43_RS44840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12390"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_106196657.1"
                     /transl_table=11
                     /translation="MEPVVGATPKDVRSEQEWRESLTPSEYRVLRQGGTEPAWVGEYTD
                     TKTVGVYECRACGTELFRSETKFDSHCGWPSFFSPLAADRVILREDRAMGMVRTEVLCA
                     HCHSHLGHVFEGEGYETPTDQRYCINSISLRLVDDSAR"
     misc_feature    3056..3070
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.71"
                     /tool="antismash"
     gene            3091..4014
                     /locus_tag="CLV43_RS44845"
                     /old_locus_tag="CLV43_12391"
     CDS             3091..4014
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="CLV43_RS44845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12391"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_170156293.1"
                     /transl_table=11
                     /translation="MDQPWGLSGPEFLRIYWIALGVALLFAVFVRMRMRASRGDGPARD
                     LGIDELAYLSGGPRRVVEASLARLIEAEALRSTRRGTVSLIGKPTAVNPVDKAVLADAA
                     RYSKRTLNLLMATVAQTDAVKSIATRLGEQGLLVDPVVAKRQARVGVVPMLVLFLIGVV
                     RWVNGIAIGAPVGWLTLQLVVTALLAVLMTRAGRIRRTARGDRALDGARTGGTGAGVTG
                     PAVAVGGAVGLVALGGLSAHPDLTLRTALMTQAYGSGSSGGGGSTYVGSSCSSSSGNSC
                     SSSSGSSCGSGGGGCGGGGGCGGGGG"
     gene            4144..5001
                     /locus_tag="CLV43_RS44850"
                     /old_locus_tag="CLV43_12392"
     CDS             4144..5001
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="CLV43_RS44850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12392"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_106196659.1"
                     /transl_table=11
                     /translation="MTSGTTISGRPGISAEEFGYLAGGPGRAAEVAVVRLLEGGLLRIS
                     REGVVSAVASGAAGAGTPLEAYALGAARTGRMLGDLVKSTATSEAASALRQHLVDRGLV
                     VSDARRKTWSTVRVLCFVAFFAAIALTIVFRVHFGVAIGVAVVALLLRWFAGRMRRPVR
                     RAGRREVGRVKVAAGDRVGMVAQMGLLGRVGQFPRMYYVWEMLGIVPSAGATLRRRKPV
                     RNSGDTGTMYGSSCNSCSSCSSGCGADNSGCGSGSSCGSSGDSGSSCSSGSSCGSSCGG
                     GGGD"
     gene            5001..5816
                     /locus_tag="CLV43_RS44855"
                     /old_locus_tag="CLV43_12393"
     CDS             5001..5816
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671915.1"
                     /locus_tag="CLV43_RS44855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12393"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_106196709.1"
                     /sec_met_domain="DUF692 (E-value: 8.5e-87, bitscore: 283.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVLDKLGVGIGWRPEIDLTVERLPGVDFVEVVAENLHVEHLPES
                     ILLLRERGVPVLPHAVSLSLGSADPVEPDRVEHLGAVAEALGAPLVSDHVCFVRAGGLD
                     SGHLMPVPRTRDALDVLVANVKTAQANLPVPLALENIAALLEWPDGELTEGQFLAELVE
                     RTDCHLLIDVANLHANALNLGTDPNRFLDEIPLERLAYVHVAGGVEHNGVYHDTHAHAV
                     RPEVLELLGELRSRVDPPGVLLERDDNYPSDTELAGELAAIRGVLARHA"
     gene            5813..6160
                     /locus_tag="CLV43_RS44860"
                     /old_locus_tag="CLV43_12394"
     CDS             5813..6160
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671914.1"
                     /locus_tag="CLV43_RS44860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12394"
                     /product="hypothetical protein"
                     /protein_id="WP_106196660.1"
                     /transl_table=11
                     /translation="MNGDQRERLARAQAELLGALLAGGPSPAGFDQRLLAVEANSLLAK
                     RRGIVAMLNPEVADVLADRFRPLFDEYARAHPRRTGSRAREDAVDFAAWARERGELPTE
                     KPNRWWRRKAT"
     gene            6186..6668
                     /locus_tag="CLV43_RS44865"
                     /old_locus_tag="CLV43_12395"
     CDS             6186..6668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466528.1"
                     /locus_tag="CLV43_RS44865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12395"
                     /product="hypothetical protein"
                     /protein_id="WP_211304864.1"
                     /transl_table=11
                     /translation="MRIVGVLGCLLVLGACGSEPEVGCTMIGTPVGIGLDVAMPEVRTA
                     TMQVCWDDKCVDPVVELHPSSSAGPQTCTGTAPTDSCGVSVVPTGGRNGFADVPDLPTA
                     PVRVTLRLSDANGVVLVDEVLTATPKPAYPNGVECGGQGPQTGLVVSAAGVVTERT"
     gene            6900..10109
                     /locus_tag="CLV43_RS44870"
                     /old_locus_tag="CLV43_12396"
     CDS             6900..10109
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099298.1"
                     /locus_tag="CLV43_RS44870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_12396"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_245887498.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 9.4e-64, bitscore:
                     208.6, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLALGLVVGATQVATAAPGGPRHFDTRDVGSVTLITGDRVVADAG
                     TGTIVPGPGREKVVFSTYAANGHRYVLPSDAAPLLASGKLDRRLFDVTELIASRYDDAH
                     RDSLSLLVTRAPGRGAAAVTGLVRTADIPTVGSFAATTAKATATTTWQALAGSPDDYRK
                     IWLDGLRQPTLDRSVPQIGAPVAWQAGYTGTGVKVAVLDTGVDATHPDLAGQELVERNF
                     TEDPDNTDTVGHGTHVAATIASDGPKYRGVAPDAKILDGKVCVTYGCAESWILNGMVWA
                     AEQGADVANLSLGGGDTPDVDPLEEAVNTLSAQYGTLFVIAAGNSGAAETVGSPGSADA
                     ALTVGAVDRDDNLAVFSSRGPRTGDGAVKPDITAPGVDIVAAKSSTGVIGTPAGDGYVS
                     LSGTSMATPHVAGSAALIKQQHPDWTGARVKAALVASAKPNPALTAYEQGAGRVDLTRA
                     ITQTVTSDPVSVGLGLQLWPHDDDVPVTKETTYRNSGTEAVTLDLALDVKGPDGKPAPE
                     GVFTVDPKTVTVPAGGAAKVSVTGDTRIGTLDGGYSGSIVATSGTTTARTPVGLVREVE
                     SYQVTLNYTGDDGAPSSTYSTFLLGFDNGGLYFPYDEDGSVELRLPKGHYYASTTIETG
                     DRTAVLPYPAFTVSRAATVELDARLAKPVSVTVPDPTATPDYAEILEARVQGESSLLTG
                     TGFPGGFDGKVSLGNVGPAVGAEEFYALVGTHWTGTPMGTTPVTYRTGKLFTGKAPTGY
                     SRVLAKRDFAEVKTRIGPSAADRDTLFAFGAVTPLGGSSGWFKPVAAPGEVVDRLAGEG
                     VEWRPSFRAYNPGDPNSAFDSVLNGNPRGYRAGKRYSETVNAAVFGPAQQATGYHLARA
                     EDTVYVDVALFGDGAGNPGYSAFDSARTTLFREGTKVGETAFDAYGQFPVPAAAASYRL
                     ETEATRAKGVSDVTTKVGGAWTFRSGHAGAEALEPLPLTLVRFQPELDAANSASAGRVL
                     RVPLVVQQNPGADNGRIGRVVVDVSFDDGKTWRRVPVVGDSALVPGGPAGGFASLRAKT
                     TDSKGNTAENTVIRAYKIAGR"
     misc_feature    10284..10299
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.27"
                     /tool="antismash"
ORIGIN
        1 ggccgaggac caggaccatt tcgctggtgg ctcctccgac gtcgccctcc atggtccagc
       61 ggaagtcgac gaaggcgtcg ctgagccatt cggccgtggc ggagcccggt acctccaggt
      121 cggcgggttc caggaaccag gcgttgcgca acgttgtgcg ccacgagccc gtgagaacgt
      181 ccaggcgggt catcgcctcg ctgcgcatcg ggtcctcctc ggaatcggaa cagtggggtg
      241 gagggtagtt ccgtcctacg cgctgtccag gctggtcagc atctgcgcgc gcaccctgga
      301 gaggtggcgg cgcatggcgc ggttggcctg gtgggtgtcg ccggcggcga tggccgccac
      361 cagggcgtcg tggtcgtcca gggaggcctg ctggtgcggc gggtcgtcct tgaggcccgc
      421 gcggagcagg acgactcgtt gttgcaccag gcggacctgt tcggcgatgc gggggcttcg
      481 ggcggcgtcg agcagggcct ggtggaaggc gaggtcgagg cggtagggga agcgggcgcc
      541 ggtgcggtgg gtgttgcggg actcggcgca gacctcgcgc aaccgttcga cgtccccgtc
      601 ggtgcggcgg ctggccgcga gctcggcggc ggcgcattcg agggcggagc ggagctcgaa
      661 gagggcgcgg acctcgtcgg cgtcggcctt ggggacgtgg gcgcccttgt tgggcacgag
      721 caccagcagg ccttcgctgg agaggtggcg gatggcctcg cggagggggc ctcggctgat
      781 gccgaggcgg tgggcgagct cgacctcgtt gacgcgttcg cccggcggga tctcgccggt
      841 gagcacgagc tcgcgcagga cgtcgacggt ctggcccgcc aggctcaggt ggagcggggg
      901 tgtcacgtgc gtctcccggg gctggtctgc gacgagtacc tcatgttaac tgtcgacagt
      961 tggcagtact tgaggaggcg gtgtggtgca cgaggtggtg gccgaggtgt ggcggggcga
     1021 gttcctggag tccgtgcacc acggcacggt cgtggcactg ggcgccgacg ggcgggcggt
     1081 gctgagcgtg gggcggccgg agctggtggc gttcccccgc tcgtcgaaca agccggtgca
     1141 ggggctggcg atggtccgcc acgggctcga cctcgacggt gagctgctgg cgctggcctg
     1201 cgccagccac tccggtgagg acttccacgt cgagggcgtg cggcggatcc tggcgaaggc
     1261 ggggctgggc ttcgacgcgc tgcagtgcac gccggacctg ccgatcgggg aggctgcgct
     1321 ggccgcgcac ctcaaggcgg gccgggggcg ggcacccgag tacatgaact gctccggcaa
     1381 gcacgccgcg atgctgctga cctgcgtgcg caacggctgg tcgaccgacg actacctggc
     1441 gttcgagcac ccgctccagg tggcgatccg ggccaccctg gaggagctgg cgggcgaacg
     1501 ggtcggggcg gtcggcgtgg acggctgcgg ggcgccgctg ttcgggatca gcctgaacgg
     1561 gctggccagg gcgttcggca ggatggccgg cgcgcgggcc gggacggagg agcaccgggt
     1621 cgcggcggcg atgaacgccc acccggagca cgtcggcggc acgggccgcg acgtcacggc
     1681 gctgatgcgc gcgctgccgg gggcgatggc caaggacggc gccgagggcg tgtacgcgat
     1741 cgggctgccg gacgggtcgg cggtggcgtt gaagatcgcc gacgggtcca gccgggcgcg
     1801 ggccgtggtg atggtggcgg cgctgcgggc gctgggcgtg gacgtggggt cgctgaccac
     1861 gttggcgacg gtcccggtcc tggggcacgg gcgcgaggtc ggcgcggtgc ggccggcttt
     1921 ggccctggcg ggctgaggaa cctctattct cgggtgatgg ccacctttcc aggcgcggga
     1981 agaccggagg acggaccgga gaagcggttc gccgacgacc tcatcgggct tgatccggcg
     2041 gaccccgagg ccaaggcctt cgcggagcac ctggaccgga tggagcggga acgccccggt
     2101 tacaccgtcg aggggtacct cgcgggggtc gcggacttcg ccgactcggc gaaccgcgcg
     2161 agcggtgagc aacgtctcgt ggcggtgctg gtggtggggc tgatcctgct cggtgtgctg
     2221 atcagcgtgt ggttcgggct cggcgagatc atctccgtgc tgttcggctg agccgtaaga
     2281 cacccgcaac ccaccccggc ccggaaaccg cattagcgtg gaggcatgga acctgttgtc
     2341 ggcgccacgc cgaaggacgt ccgttcggag caggagtggc gggagagcct gaccccgagc
     2401 gagtaccggg tgctccgcca gggcggcacc gagcccgcct gggtcggcga gtacacggac
     2461 accaagaccg tcggtgtcta cgagtgccgc gcgtgcggca cggagctgtt ccgcagcgag
     2521 accaagttcg actcgcactg cgggtggccg tcgttcttct ccccgctggc cgcggaccgc
     2581 gtgatcctgc gcgaggaccg cgccatgggc atggtccgca cggaggtgct ttgcgcgcat
     2641 tgccacagcc acctcgggca cgtgttcgag ggcgagggtt acgagacccc gaccgaccag
     2701 cgctactgca tcaacagcat cagcctgcgt ttggtcgacg actccgcgcg gtgacgtgcc
     2761 cattcccgaa tagcgccgca acgcggtcgc acgagtgcgg aaagcaacag gcgacacagc
     2821 gctcgcggtg cagcagactg gacttgtcgc accggatggc gccagtccgc ggcgccaccc
     2881 ggactcgtct ctgacctggg aggaagcatg ctttcgcgca agggcaccga cggtgagggg
     2941 tccagtgggg tcgacgggtc gtcgtcctcc taagaaccgc ctaataccag cctaagtctt
     3001 gctcaagccc cttgccgctg tgtgttccgc agcacagtat tgcctttcga ttggcggatt
     3061 cgttccgcca agagcggtag ggggtggacc gtggaccagc cgtgggggct ctcgggcccg
     3121 gaattcctga ggatctactg gatcgcgttg ggcgtcgccc tgctgttcgc ggtcttcgtc
     3181 cggatgcgca tgcgggccag tcggggtgac gggcccgcac gcgatctcgg catcgacgag
     3241 ctggcgtacc tgtccggcgg gccgcgccgg gtcgtcgagg cctcgctggc ccggctgatc
     3301 gaggccgagg ccctgcgctc gacgcgccgc ggcaccgtca gcctgatcgg caagcccacc
     3361 gcggtgaacc cggtggacaa ggccgtgctg gcggacgccg cccgctacag caagcgcacg
     3421 ctgaacctcc tgatggccac cgtcgcgcag accgacgcgg tgaagtcgat cgcgacccgc
     3481 ctcggtgagc agggactgct cgtggacccc gtcgtggcca agcggcaggc gcgggtgggt
     3541 gtcgtgccga tgctggtgct gttcctgatc ggggtcgtcc gctgggtcaa cgggatcgcg
     3601 atcggcgctc ccgtcggctg gctgacgctc cagctggtgg tcaccgcgct gctggcggtg
     3661 ctgatgacca gggcgggccg gatccggcgc acggccaggg gtgaccgcgc gctggacggc
     3721 gcccgcaccg gtggcaccgg ggccggggtg accggcccgg ccgtggccgt gggcggggcg
     3781 gtcggcctgg tcgcgctcgg cggcctgtcg gcgcaccctg acctgacgct gcggaccgcg
     3841 ctgatgaccc aggcctacgg gtcgggttcg tccggcggcg gcggctcgac gtacgtgggg
     3901 agctcgtgct cgagctccag cggcaactcc tgctccagct ccagcggcag cagctgcggc
     3961 agcgggggtg gcggttgcgg gggtggcggc ggctgcggtg ggggcggcgg ctgaccgcag
     4021 gggggcgcca aggccatcac cggacgtcgt gacgtcctcg tgatggcctt ggccgcgtga
     4081 cgcggaacga acaggcccgc cgcggagtcg gatggccatc ggcttgggtg aaaggcggcg
     4141 gtcatgactt ccgggacgac gatatcgggc agaccaggga tctcggccga ggagttcggc
     4201 tacctggcgg gcggtcctgg ccgcgccgcg gaggtggcgg tcgtccggct cctggagggc
     4261 gggctgctgc ggatctcccg cgagggcgtg gtgagcgcgg tggcctcggg cgccgcgggc
     4321 gcgggcacgc cgctggaggc gtacgcgctg ggcgcggccc gcaccggccg gatgctgggc
     4381 gacctggtca agtccacggc caccagcgag gcggcctcgg cgctgcggca gcacctggtc
     4441 gaccggggcc tggtcgtgtc cgacgcccgc cgcaagacgt ggtcgacggt ccgggtgctc
     4501 tgcttcgtcg cgttcttcgc cgccatcgcc ctcacgatcg tgttccgggt gcacttcggg
     4561 gtcgcgatcg gcgtggccgt ggtggcgctg ctgctgcgct ggttcgcggg ccggatgcgg
     4621 cgcccggtgc gccgggcggg caggcgcgag gtcggccggg tcaaggtggc cgcgggcgac
     4681 cgggtgggca tggtcgcgca gatgggcctg ctgggccggg tcggccagtt cccgcggatg
     4741 tactacgtgt gggagatgct gggcatcgtg ccgagcgccg gtgccacgct gcgcaggcgc
     4801 aagcccgtcc gcaacagcgg cgacaccggc acgatgtacg ggagcagctg caacagctgc
     4861 tccagctgct ccagcgggtg cggtgccgac aacagcgggt gcggcagcgg cagcagctgc
     4921 gggtcgagcg gcgacagcgg gtcgtcgtgc agcagcggct cgtcctgcgg gtcgtcgtgc
     4981 ggtggagggg gcggggactg atgggcgtgc tggacaagct cggcgtcggc atcggctggc
     5041 gcccggagat cgacctgacc gtggaacggc tgcccggcgt cgacttcgtc gaggtggtgg
     5101 ccgagaacct gcacgtggag cacctgccgg agtcgatcct gctgctgcgc gaacggggtg
     5161 tcccggtgct gccgcacgcg gtgtcgctgt cgctgggcag cgcggacccc gtcgagccgg
     5221 accgcgtcga gcacctgggc gcggtcgccg aggcgctggg ggcgccgctg gtgagcgacc
     5281 acgtctgctt cgtccgcgcg ggcgggctcg actcgggcca cctgatgccg gtgccgcgca
     5341 cccgcgacgc gctggacgtg ctggtggcca acgtgaagac ggcgcaggcg aacctgccgg
     5401 tgccgctggc gctggagaac atcgccgccc tgctggagtg gcccgacggc gagctgaccg
     5461 agggccagtt cctcgccgag ctggtcgagc gcaccgactg ccacctgctg atcgacgtgg
     5521 cgaacctgca cgcgaacgcg ctcaacctgg gcacggaccc gaaccggttc ctcgacgaga
     5581 tcccgttgga gcggctggcc tacgtgcacg tggcgggcgg cgtcgagcac aacggcgtct
     5641 accacgacac gcacgcccac gcggtgcggc cggaggtgct ggagctgctg ggcgagctgc
     5701 ggtcgcgggt ggacccgccg ggcgtgctgc tggagcgcga cgacaactac ccgtcggaca
     5761 ccgagctggc gggcgagctg gccgcgatcc gcggggtgct ggcgaggcac gcgtgaacgg
     5821 ggaccagcgc gagcggctcg cacgggcgca ggcggagctg ctcggcgcgc tgctcgcggg
     5881 cggcccctcc cccgccgggt tcgaccagcg gctgctggcg gtcgaggcga actccttgct
     5941 ggccaagagg cgcggcatcg tggcgatgct gaaccccgag gtcgccgacg tgctggccga
     6001 ccgcttccgg ccgctgttcg acgagtacgc ccgcgcgcac ccgcgcagga cgggcagccg
     6061 ggcgcgggag gacgcggtgg acttcgcggc gtgggcgcgg gaacgcggcg agctccccac
     6121 cgagaaaccg aatcgctggt ggcggaggaa ggcaacctga agcggtccac ccccgtctgg
     6181 tggtcatgag gatcgtcggg gtgctgggtt gcctgctggt gctgggtgcg tgcgggtctg
     6241 agcccgaggt cggctgcacg atgatcggga caccggtggg gatcgggctg gacgtggcga
     6301 tgcccgaggt gcggaccgcg accatgcagg tctgctggga cgacaagtgc gtcgaccccg
     6361 tcgtggagct gcacccgtcg tcctcggcgg gcccgcagac gtgcaccggc accgccccga
     6421 cggactcgtg cggggtgtcg gtcgtgccga ccggcggccg caacggcttc gcggacgtcc
     6481 ccgacctgcc caccgcgccg gtgcgggtca ccctgcggct gtcggacgcg aacggcgtgg
     6541 tgctcgtcga cgaggtgctg accgcgacgc cgaaacccgc ctaccccaac ggtgtcgagt
     6601 gcggcgggca gggcccgcag accggcctgg tggtgtccgc cgcgggggtc gtgaccgagc
     6661 ggacctgacc cgcgcaagtc aggggttcgg atcgtggaac ttgggccatt gggagcagcc
     6721 gcggtcgtga cggggtcgct aggttcgggg cgctgggggg atttcgtcac tttcggtaca
     6781 ccgctgccgc cgtctgccag acgccttcca gcagcgcatc cgggtgggtg cgcgtccctg
     6841 gaggggagag ttcgccgttg cgatcgacac gacggcacgg caagcggctt ggcgcttgcg
     6901 tgctcgcact gggactggtg gtcggggcca cgcaggtggc gacggccgcg ccgggcggac
     6961 cccggcactt cgacacccgt gacgtcggtt ccgtcacgct gatcaccggg gaccgggtgg
     7021 tcgcggacgc ggggacgggc acgatcgtcc ccggtccggg ccgcgagaag gtggtcttct
     7081 ccacctacgc cgcgaacggc caccggtacg tgctgccgag cgacgcggcg ccgctgctgg
     7141 cctcgggcaa gctggaccgc aggctgttcg acgtcaccga gctcatcgcg tcgcgctacg
     7201 acgacgcgca ccgcgacagc ctgtcgctgc tggtcacccg cgcgccgggc cgcggcgccg
     7261 cggccgtcac cgggctggtc cggaccgccg acatcccgac ggtgggctcg ttcgcggcga
     7321 ccacggcgaa ggccaccgcg acgacgacct ggcaagcgct tgccggctca ccggacgact
     7381 accgcaagat ctggctcgac ggcctgcggc aaccgaccct ggaccgcagc gtgccgcaga
     7441 tcggcgcgcc ggtggcgtgg caggccgggt acaccggtac cggtgtgaag gtcgccgtgc
     7501 tcgacaccgg cgtcgacgcc acgcaccccg acctggcggg ccaggagctg gtggagcgca
     7561 acttcaccga ggacccggac aacaccgaca cggtcggcca cggcacgcac gtcgcggcga
     7621 ccatcgccag cgacgggccc aagtaccgcg gcgtggcacc cgacgcgaag atcctcgacg
     7681 gcaaggtctg cgtgacctac ggctgcgcgg agtcgtggat cctcaacggg atggtgtggg
     7741 ccgccgagca gggcgcggac gtggcgaacc tgagtctggg cggcggggac accccggacg
     7801 tcgacccgct cgaagaggcc gtgaacacgc tttccgccca gtacggcacg ctgttcgtga
     7861 tcgccgcggg caactccggc gccgccgaga ccgtcggctc ccccggcagc gcggacgccg
     7921 cgctgaccgt cggcgcggtg gaccgcgacg acaacctcgc ggtgttctcc agccgcggtc
     7981 cgcgcaccgg cgacggcgcg gtcaagccgg acatcaccgc gcccggcgtg gacatcgtgg
     8041 cggcgaagtc ctccacgggc gtcatcggca ccccggcggg cgacgggtac gtgtcgctgt
     8101 cgggcacctc gatggcgacc ccgcacgtcg cgggctcggc ggcgctgatc aagcagcaac
     8161 accccgactg gacgggcgcg cgggtcaagg cggcgctggt cgcctccgcc aagccgaacc
     8221 ccgcgctgac cgcgtacgag cagggcgccg ggcgggtgga cctgaccagg gccatcaccc
     8281 agacggtgac cagcgacccg gtgagcgtcg ggctggggct ccagctgtgg ccgcacgacg
     8341 acgacgtgcc ggtcacgaag gagaccacct accgcaactc cgggaccgag gccgtgacgc
     8401 tggacctggc gctcgacgtc aagggcccgg acggcaagcc cgcgcccgag ggcgtcttca
     8461 cggtcgaccc caagacggtc accgtccccg cgggcggcgc ggcgaaggtc tccgtcaccg
     8521 gtgacaccag gatcggcacg ctggacggcg gctacagcgg ctcgatcgtc gccacctccg
     8581 gcacgacgac ggcgcgcacc ccggtcggcc tcgtgcgcga ggtcgagagc taccaggtca
     8641 cgctgaacta caccggcgac gacggcgcgc cctcctccac ctactcgacg ttcctgctcg
     8701 gcttcgacaa cggcggcctc tacttcccct acgacgagga cggcagcgtc gagctccggc
     8761 tccccaaggg gcactactac gcctcgacga ccatcgagac cggggaccgg accgcggtgc
     8821 tgccctaccc cgccttcacc gtgtcgcggg cggccaccgt cgagctcgac gcgcggctgg
     8881 cgaagccggt ctccgtgacc gtgccggacc cgacggcgac gccggactac gccgagatcc
     8941 tcgaggcgcg cgtgcagggc gagagcagcc tgctcaccgg cacgggcttc cccggcggct
     9001 tcgacggcaa ggtctcgctc ggcaacgtcg gaccggcggt gggcgcggag gagttctacg
     9061 cgctggtcgg cacgcactgg accgggacgc cgatgggcac cacgcccgtc acctaccgga
     9121 ccggcaagct gttcaccggc aaggcgccca ccgggtactc ccgcgtcctg gccaagcggg
     9181 acttcgccga ggtcaagacc aggatcgggc cgagcgccgc ggaccgggac accctgttcg
     9241 cgttcggcgc ggtcaccccc ctcggcggct ccagcgggtg gttcaagccc gtcgccgcgc
     9301 ccggcgaggt ggtcgaccgg ctcgcgggcg agggcgtcga gtggcggccg tccttccggg
     9361 cgtacaaccc cggcgacccg aactcggcgt tcgacagcgt cctgaacggc aacccccgcg
     9421 gctaccgggc cgggaagcgc tactccgaga cggtcaacgc ggccgtgttc gggcccgccc
     9481 agcaggcgac cgggtaccac ctcgccaggg cggaggacac ggtctacgtc gacgtggcgc
     9541 tgttcggcga cggcgcgggc aaccccggct actcggcgtt cgactccgcc cgcaccacgc
     9601 tgttccgcga gggcacgaag gtcggtgaga ccgccttcga cgcttacggg cagttccccg
     9661 tgcccgccgc cgcggcctcc taccggctgg agaccgaggc gacccgcgcc aagggcgtct
     9721 cggacgtgac gacgaaggtg ggcggtgcct ggacgttccg ctccgggcac gcgggcgccg
     9781 aggcgctcga acccctgccg ctgacgctgg tccggttcca gcccgagctc gacgcggcga
     9841 actcggcttc cgccgggcgg gtgctgcggg tcccgctggt ggtccagcag aaccccggcg
     9901 ccgacaacgg ccggatcggg cgggtcgtgg tcgacgtgtc gttcgacgac ggcaagacct
     9961 ggcggcgcgt gcccgtcgtc ggtgactcgg cgctggtgcc cggcggtccc gcgggcggct
    10021 tcgcgtcgtt gcgcgccaag acgaccgaca gcaagggcaa cacggccgag aacacggtga
    10081 tccgggcgta caagatcgcc gggaggtagt ccgcggccgg gcccgtggca catcgtcgcc
    10141 acgggcccgg tcagggccgt ggaccggccc gcacgagccc ggcgccggcg tccgaccaac
    10201 ggacgccggt gtccgagccg ggaattcgcg ggttgcaccg gagcggaccc gtgacacaca
    10261 ttcgccctcc cgccacggga gggtcgcacg actcttcgag atcgatatgt tcggagcgcc
    10321 cgggactttc gtcacgatcg gtgcaccgcc ccccaccgat cggccgacgc cccctgggct
    10381 gtgcacccct gcacgcgctc caccgaatcg ggaggtggct gttgcgatca actcgacgac
    10441 acggcgctct actgggagtc gccgcgctcg cgttcggact cgtggtcggg tccacgggcg
    10501 tgtcggaggc ggaagggtct ccgccgggct tcagcgcgcc gggaggcgcc ggttccgtca
    10561 cgctcatcac cggtgaccgc gtcgtgctcg acggcgcggg ggcgggctcg atcgtccccg
    10621 gctccggccg gaacggcgtc gtcttctcca cgtccacgga ggacggtcac ctgttcgtcg
    10681 tgcccgccga cgcccggcgc gacctcgcct cgggcaggct ggaccggcgg ctgttcgacg
    10741 tcaccgagct catcgcctcg cgctacgacg acgcgcaccg cgactcggtg ccgctgatca
    10801 tcacgaccgg caagga
//
