LOCUS       NZ_PVTF01000018        22550 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Umezawaea tangerina strain DSM 44720 Ga0180964_118, whole genome
            shotgun sequence.
ACCESSION   NZ_PVTF01000018
VERSION     NZ_PVTF01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Umezawaea tangerina
  ORGANISM  Umezawaea tangerina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Umezawaea.
REFERENCE   1  (bases 1 to 166491)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 166491)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Expected Final Version            :: No
            Genome Coverage                   :: 86.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003002815.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:47:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,483
            CDSs (total)                      :: 9,418
            Genes (coding)                    :: 9,322
            CDSs (with protein)               :: 9,322
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 20 of 97
            Pseudo Genes (incomplete)         :: 83 of 97
            Pseudo Genes (internal stop)      :: 2 of 97
            Pseudo Genes (multiple problems)  :: 8 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:41:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 117720
            Orig. end                         :: 140270
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVTF01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22550
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="2"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22550
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22550
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12550](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12550
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(9..24)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.83"
                     /tool="antismash"
     gene            complement(567..1361)
                     /locus_tag="CLV43_RS41530"
                     /old_locus_tag="CLV43_118115"
     CDS             complement(567..1361)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099014.1"
                     /locus_tag="CLV43_RS41530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118115"
                     /product="hypothetical protein"
                     /protein_id="WP_106195619.1"
                     /transl_table=11
                     /translation="MGSQITEGLGQAWAMIATFVPKLLGFALVMVVGWFIAKALSKAVG
                     FLLKRVGFDRLVERSGLGAMTAQSPVDASGLIVKLVYYFVLLIALQMAFGVFGTGNAVS
                     ELLNDVIAYLPRIVVALVLVLVASAIGKAVRGLVTGALGGRSYTRMLGTAAYGFIMALG
                     VIAALNQLGIAVSVTMPVLIAVLATVAGVVIIGVGGGLVRPMQQRWEGWLTRVQDEAAR
                     TAPAPRRSQEPVSAGARRHATAQQMASDAPTPPAGMPITPGE"
     misc_feature    1403..1414
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.33"
                     /tool="antismash"
     gene            complement(1563..3074)
                     /locus_tag="CLV43_RS41535"
                     /old_locus_tag="CLV43_118116"
     CDS             complement(1563..3074)
                     /NRPS_PKS="Domain: Abhydrolase_1 (77-231). E-value:
                     1.4e-16. Score: 52.8. Matches aSDomain:
                     nrpspksdomains_CLV43_RS41535_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099013.1"
                     /locus_tag="CLV43_RS41535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118116"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_245887416.1"
                     /sec_met_domain="PF00561 (E-value: 7.1e-23, bitscore: 74.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLAVLVVLATSSPAVSARTTPPDPLAEFHNQTLTWAPCQGDLEC
                     ASVVVPLDYADPGLDRISLAVSRRKATELRRGVLVANPGGPGGSGLRMPAFLSTTALAK
                     SYDLIGFDPRGVGGSTALTCRAVPEITTTDSRPPDSEFAKWTAEARAAEDACQASAGGI
                     RRFVNTANTARDLDVIREVLGEPRISYLGYSYGTYLGAVYGSLFPYRLDRSVLDSSVHP
                     EWLWRQQAKGQAVATRRNVELWSEWAAEHDDVFGLGRSGPEVLATIERTSARLALDPVG
                     AHTRSEFDAAVGVGSRYRPLWTDLAGVVGGLNGGAGTTPQAAAEQSARFAASAKGELKS
                     GVFTTITCEADWPRDLETYYEDMRVFRDRYPYGFGVLRAAPTACTFRSFTPPGPMVPLK
                     RDGYPVGLVVQAEGDTQTQYEGGPAMASRLGDNLLTVLDEGKHGVYNSGNACVDAVVDH
                     YLVDGVLPPSSSTCPGDPRPDPARPSTRPAGSFLDTAGLAERLAR"
     aSDomain        complement(2382..2843)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS41535_Abhydrolase_1.1"
                     /evalue="1.40E-16"
                     /label="CLV43_RS41535_Abhydrolase_1.1"
                     /locus_tag="CLV43_RS41535"
                     /protein_end="231"
                     /protein_start="77"
                     /score="52.8"
                     /tool="antismash"
                     /translation="VLVANPGGPGGSGLRMPAFLSTTALAKSYDLIGFDPRGVGGSTAL
                     TCRAVPEITTTDSRPPDSEFAKWTAEARAAEDACQASAGGIRRFVNTANTARDLDVIRE
                     VLGEPRISYLGYSYGTYLGAVYGSLFPYRLDRSVLDSSVHPEWLWRQQAK"
     gene            3210..4412
                     /locus_tag="CLV43_RS41540"
                     /old_locus_tag="CLV43_118117"
     CDS             3210..4412
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099012.1"
                     /locus_tag="CLV43_RS41540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118117"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_106195623.1"
                     /transl_table=11
                     /translation="MTSSAGAEGQQAWPELSRTTLRDLERASGDLAASSVSEMERRLPW
                     FRRMPADQRASVLLLIQNGVAGFVSWLDDPRQAIRLTAEAFRSAPKDISRWVSLRQTVE
                     LVRIALELFEQQLPRLAADDAERARLTEGVLRYGREIAFSAATSYAAAAEARGAWDARL
                     EALVVDGIVRGDAEESLLSRAAALGWDPAAEATVLVGNPPSDDPPAVVYEVRSRAARSA
                     RPVLLSVQGSRLVVVLGGETDDGDVLGKIAEAFGDGAVVAGPTVASLAEAHRSASDALS
                     GLRAVVGWPTAPRPVRSLDLLPERALAGDPEAEWQLVDRIARPLEEASGSLLETVDTFL
                     EVGGVLETCARKLFVHPNTVRYRLRRVTELTGRNAHDARDALVLRIALSVGRLAKARGL
                     W"
     misc_feature    4528..4541
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.1"
                     /tool="antismash"
     misc_feature    4529..4543
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.16"
                     /tool="antismash"
     misc_feature    complement(4530..4543)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.5"
                     /tool="antismash"
     misc_feature    complement(4533..4549)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.78"
                     /tool="antismash"
     gene            4617..5546
                     /locus_tag="CLV43_RS41545"
                     /old_locus_tag="CLV43_118118"
     CDS             4617..5546
                     /EC_number="2.3.1.39"
                     /GO_function="GO:0004314 - [acyl-carrier-protein]
                     S-malonyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_AT (6-284). E-value: 4.8e-44. Score:
                     142.8. Matches aSDomain:
                     nrpspksdomains_CLV43_RS41545_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010231567.1"
                     /locus_tag="CLV43_RS41545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118118"
                     /product="ACP S-malonyltransferase"
                     /protein_id="WP_106195625.1"
                     /sec_met_domain="PKS_AT (E-value: 1.2e-43, bitscore: 142.8,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIALLAPGQGSQTPGMLAPWLELDGARQRVDAWAEATGLDLVRLG
                     TTAEAEEIKDTSITQPLVVALALLAFEELRRRVELPSDTIIGGHSVGELAAAAMAGVLS
                     ADDAVALAAVRGAEMAAACALHPTGMAAVLGGDEAEVLARLAELELTPANRNGAGQIVA
                     AGPLDALDKLVESPPGTAKIRKLQVAGAFHTAFMAPAEEALRTRAADVVANDPALPLLS
                     NADGTIVTDGADVLRRLISQVTRPVRWDTCQATLAGHAVHAVVELPPAGALTGLAKREL
                     KGTPTLALKTPEHLDKVAELLATAEAGR"
     CDS_motif       4635..4667
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CLV43_RS41545_0001"
                     /evalue="3.50E-03"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="CLV43_RS41545"
                     /protein_end="17"
                     /protein_start="6"
                     /score="10.5"
                     /tool="antismash"
                     /translation="PGQGSQTPGML"
     aSDomain        4635..5468
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS41545_PKS_AT.1"
                     /evalue="4.80E-44"
                     /label="CLV43_RS41545_PKS_AT.1"
                     /locus_tag="CLV43_RS41545"
                     /protein_end="284"
                     /protein_start="6"
                     /score="142.8"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="PGQGSQTPGMLAPWLELDGARQRVDAWAEATGLDLVRLGTTAEAE
                     EIKDTSITQPLVVALALLAFEELRRRVELPSDTIIGGHSVGELAAAAMAGVLSADDAVA
                     LAAVRGAEMAAACALHPTGMAAVLGGDEAEVLARLAELELTPANRNGAGQIVAAGPLDA
                     LDKLVESPPGTAKIRKLQVAGAFHTAFMAPAEEALRTRAADVVANDPALPLLSNADGTI
                     VTDGADVLRRLISQVTRPVRWDTCQATLAGHAVHAVVELPPAGALTGLAKRELKGT"
     CDS_motif       4878..4973
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CLV43_RS41545_0002"
                     /evalue="1.40E-12"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="CLV43_RS41545"
                     /protein_end="119"
                     /protein_start="87"
                     /score="39.6"
                     /tool="antismash"
                     /translation="GHSVGELAAAAMAGVLSADDAVALAAVRGAEM"
     CDS_motif       4968..5045
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CLV43_RS41545_0003"
                     /evalue="6.60E+01"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="CLV43_RS41545"
                     /protein_end="143"
                     /protein_start="117"
                     /score="-3.1"
                     /tool="antismash"
                     /translation="EMAAACALHPTGMAAVLGGDEAEVLA"
     gene            5543..6520
                     /locus_tag="CLV43_RS41550"
                     /old_locus_tag="CLV43_118119"
     CDS             5543..6520
                     /EC_number="2.3.1.180"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683046.1"
                     /locus_tag="CLV43_RS41550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118119"
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="WP_106195627.1"
                     /sec_met_domain="fabH (E-value: 1.7e-106, bitscore: 349.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSIKLPAALSGTRILGIGSYQPETIVTNHDLAKVMETSDEWIRD
                     RVGIVSRRFAGKDEKLTDMAVEAGAKAIADSGLTPGDVDAVIVATCTMPSPIPNAAAQV
                     AERIGVTAAPAFDVNAACAGFCYALATASDMVRSGSSRNVLVIGAEKLTDWVDPTDRST
                     AIIFADAAGAVVVGPGDEPSIGPVAWGSAGELADTIAIADRNSSIHQEGQAVFRWATTQ
                     IAPVAIRAVELAGVELSDVDVFVPHQANLRIVEAIAKRLRSKGAREDMVIARDIVESGN
                     TSSASIPMALDHMRAAGEISSGDVVLLMGFGAGLSYAGQVVRCP"
     misc_feature    complement(6582..6596)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.62"
                     /tool="antismash"
     gene            6597..6836
                     /locus_tag="CLV43_RS41555"
                     /old_locus_tag="CLV43_118120"
     CDS             6597..6836
                     /NRPS_PKS="Domain: PP-binding (9-75). E-value: 4.6e-19.
                     Score: 60.5. Matches aSDomain:
                     nrpspksdomains_CLV43_RS41555_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947996.1"
                     /locus_tag="CLV43_RS41555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118120"
                     /product="acyl carrier protein"
                     /protein_id="WP_106195628.1"
                     /sec_met_domain="PP-binding (E-value: 1e-18, bitscore:
                     60.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.00077, bitscore:
                     13.0, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNEDIQKGLAEIVEEVAGVAADDVTVEKSFVDDLDIDSLSMVEI
                     AVQAEDKFGVKIPDDELANLKTVGDAVTYIASKA"
     aSDomain        6624..6821
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS41555_PP-binding.1"
                     /evalue="4.60E-19"
                     /label="CLV43_RS41555_PP-binding.1"
                     /locus_tag="CLV43_RS41555"
                     /protein_end="75"
                     /protein_start="9"
                     /score="60.5"
                     /tool="antismash"
                     /translation="LAEIVEEVAGVAADDVTVEKSFVDDLDIDSLSMVEIAVQAEDKFG
                     VKIPDDELANLKTVGDAVTYI"
     gene            6833..8068
                     /locus_tag="CLV43_RS41560"
                     /old_locus_tag="CLV43_118121"
     CDS             6833..8068
                     /EC_number="2.3.1.179"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (66-406). E-value:
                     1.2e-49. Score: 161.3. Matches aSDomain:
                     nrpspksdomains_CLV43_RS41560_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FabF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011873384.1"
                     /locus_tag="CLV43_RS41560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118121"
                     /product="beta-ketoacyl-ACP synthase II"
                     /protein_id="WP_106195630.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.7e-61, bitscore:
                     201.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="FabF (E-value: 2.1e-172, bitscore: 566.7,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTNHDVVVTGLGATTPLGGDVATTWDALLAGRSGVSTNNMDWVE
                     RFDLPVRIAAQLAVDPTEVLPRVEARRLDRSEQVAMIAAREAWKDAGHSDDTVDKDRLA
                     VIVGTGIGGAMTLLNQDDLLEEHGLRKVSPLTVPMLMPNGPAAHVGLEFKARAGVHAPV
                     SACASGAEALAWAWRMIRTGEADVVVAGGAEACICAIPVAGFSQARTMSTRNDEPEKAS
                     RPFDTGRDGFVLGEGAGIMVLERADFAAARGAKVYGRLAGIGTSSDGYHITAPDPEGTG
                     QARAISAALRTAGLDPSDVGHVNCHATSTPVGDVAETVAIRKAIGDHPVLNAPKGALGH
                     LLGAAGAVEGIVTLLSIRDGVIPQTLNLDNLDPAVELDVVAGEPRKVKLEAAVNDAFGF
                     GGHNVALAFTPA"
     aSDomain        7031..8050
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS41560_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.20E-49"
                     /label="CLV43_RS41560_PKS_KS.1"
                     /locus_tag="CLV43_RS41560"
                     /protein_end="406"
                     /protein_start="66"
                     /score="161.3"
                     /tool="antismash"
                     /translation="RVEARRLDRSEQVAMIAAREAWKDAGHSDDTVDKDRLAVIVGTGI
                     GGAMTLLNQDDLLEEHGLRKVSPLTVPMLMPNGPAAHVGLEFKARAGVHAPVSACASGA
                     EALAWAWRMIRTGEADVVVAGGAEACICAIPVAGFSQARTMSTRNDEPEKASRPFDTGR
                     DGFVLGEGAGIMVLERADFAAARGAKVYGRLAGIGTSSDGYHITAPDPEGTGQARAISA
                     ALRTAGLDPSDVGHVNCHATSTPVGDVAETVAIRKAIGDHPVLNAPKGALGHLLGAAGA
                     VEGIVTLLSIRDGVIPQTLNLDNLDPAVELDVVAGEPRKVKLEAAVNDAFGFGGHNVAL
                     "
     gene            complement(8696..9298)
                     /locus_tag="CLV43_RS41565"
                     /old_locus_tag="CLV43_118122"
     CDS             complement(8696..9298)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV43_RS41565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV43_118122"
                     /product="hypothetical protein"
                     /protein_id="WP_106195632.1"
                     /transl_table=11
                     /translation="MTTDEHRRPRARWVLPTAVLVAAASVAGGFLARDLYQRPASPGAS
                     GTAPSTSSTSSSVPRSNQPGDPAVTLSVDASFHPDGTRVKEVLQRYFDAINSRDFQTWR
                     TVVTKDFSRPFTEAKWQRDYDSTTDGTVMVQRIEAASTDRLRVMISFISVQDPTKAPVE
                     LPEDCIRWHVVYPLRNEDDSLRVDTGPEGYTPQFEAC"
     misc_feature    9399..9415
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 21.9"
                     /tool="antismash"
     misc_feature    complement(9454..9469)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.56"
                     /tool="antismash"
     misc_feature    complement(9478..9492)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     misc_feature    complement(9520..9532)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.85"
                     /tool="antismash"
     misc_feature    9602..9618
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 21.87"
                     /tool="antismash"
     misc_feature    complement(9661..9674)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.07"
                     /tool="antismash"
     misc_feature    9780..9797
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    complement(9965..9982)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.08"
                     /tool="antismash"
     gene            10001..12550
                     /gene="lanKC"
                     /locus_tag="CLV43_RS41570"
                     /old_locus_tag="CLV43_118123"
     CDS             10001..12550
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658751.1"
                     /locus_tag="CLV43_RS41570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118123"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_106195634.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1086.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.7e-15, bitscore: 50.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.7e-12, bitscore:
                     40.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRYEAYCFADRHFYDVQSHAETSVDDFSRELPELPDGWSQGEK
                     NIWRHLHPKGAVLAKQGWKIHVSATVANAGRVLKATYDYCVEHRISFKYLRTQSIVLAR
                     NSKYAPREASGKLVAIYPADEVELERILVELSELLDGEDGAYILSDLRYGAGPLYVRYG
                     GFVEQWLERDGKQVLAIEGPDGELVPDQRKPNFWVPEWVELPAFLVPHLAARNGGDPDE
                     FPYDVVRSLHFSNGGGVYLATRKADGAEVVLKEARPHAGLDRDNTDAVVRLDREFKILT
                     RLDGIPGVPQVYDRFTVWEHHFLAMEYMPGRPLGQWLGMHYPLTHNGVGDERITEYTAR
                     ALAVVDRVEATVEALHQRGVVFADLHSLNILLDDDDSMSLIDFELSFHLDAPRRPTLGA
                     PGFQAPPDREGFEIDEYPLAALRLWLFLPLNEVLELAPSRLRSHLDFIRRRFGLSEEYC
                     ARIERVLTPRGEVPPAPARTSLDERDPDWRAVCRDITTAILASATPERTDRLFPGDIEQ
                     FEVGGACFAYGAAGVLHALHVSGQGRFPEYEQWLQDSVRRDPPKQPGFFTGAHGIAYVL
                     EEFGHQELATDLVTEYAKTLPGTVDHGLGSGLSGVGLNLLHFADVREDDDFLGQAIGIA
                     DRLGLELQLAEGPGPKAKAGLLHGWSGPALLFLRLFEHSGDRGWLDLAGQALDRDLAEC
                     MVALDGSTQVRDGGYRTLPYVEVGGAGIALVLNQYARHAPDAESVTRLPDLLRGAAGEF
                     VIHPGLVLGRMGLLATLAQAVRRQPDPVFEQAMRRHLAALAWHAVPYRDGLAFPGMQLR
                     RLSMDLNTGGAGVLLALASVMDGDASVLPFLGAAPTP"
     misc_feature    complement(12595..12609)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.63"
                     /tool="antismash"
     misc_feature    complement(12613..12627)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    12617..12632
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            12618..12773
                     /locus_tag="CLV43_RS41575"
                     /old_locus_tag="CLV43_118124"
     CDS             12618..12773
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800163.1"
                     /locus_tag="CLV43_RS41575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118124"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_106195636.1"
                     /transl_table=11
                     /translation="MGFILDMQELETPEAPSNAMASGHGGGGSTTASSASLLLPCSHSS
                     ASLVLC"
     CDS_motif       12618..12677
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGFILDMQELETPEAPSNAM"
                     /locus_tag="CLV43_RS41575_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12678..12773
                     /prepeptide="core"
                     /locus_tag="CLV43_RS41575_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="9.00"
                     /molecular_weight="2617.9"
                     /monoisotopic_mass="2616.3"
                     /core_sequence="ASGHGGGGSTTASSASLLLPCSHSSASLVLC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGFILDMQELETPEAPSNAM"
                     /leader_location="[12617:12677](+)"
                     /alternative_weights="2635.9"
                     /alternative_weights="2653.9"
                     /alternative_weights="2671.9"
                     /alternative_weights="2689.9"
                     /alternative_weights="2708.0"
                     /alternative_weights="2726.0"
                     /alternative_weights="2744.0"
                     /alternative_weights="2762.0"
                     /alternative_weights="2780.0"
     gene            12928..14553
                     /locus_tag="CLV43_RS41580"
                     /old_locus_tag="CLV43_118125"
     CDS             12928..14553
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669539.1"
                     /locus_tag="CLV43_RS41580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118125"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_106195638.1"
                     /transl_table=11
                     /translation="MAQPGDALLVEAADHDRRWLLLVLNAALATTAGLVLPAALANTVD
                     MALAGRLDPTTVLWLVSLVSVEVVGDAIGVVLAAAITARVTAWLRHRVSAHLLGLGHPS
                     PFAAGDAVSRVTGDSAIAGGISVILIVLVVTVVSSVGAVVALALMDWRLAAVFLLSVPL
                     AMLLVRTHMRLTADDVATYQNVSGELSARLLDAVSGLRTIAVSGTAEQESRRVLRPLPT
                     LAAAGIGMWRTQAKMIWRAGLLLPAVELAVLTAAGFGVVAGRLTIGDLLATLGYVALGM
                     GVVGQLPALTTFARTRASATRLVEVLDTPLPRRDAPPAPASAGDLELHNVTVEGALRDV
                     HLRIPAGTFVAVVGRSGAGKSALAAVIGGLSTPDTGEVRRDGEVGYAFERPALLGATVG
                     ESIRYGADAGKRRVRAACVAAQVHDVVVRLPQGYDTPMADTPLSGGEAQRLGLARALAR
                     DPDVLVLDDATASLDMVTEASVDKAIEAALPGRTKVVVTHRAATARRADLVVWLVDGEV
                     RATGPHEALWLDPDYRAVFTGGDV"
     gene            14630..16351
                     /locus_tag="CLV43_RS41585"
                     /old_locus_tag="CLV43_118126"
     CDS             14630..16351
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030767.1"
                     /locus_tag="CLV43_RS41585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118126"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_106195639.1"
                     /transl_table=11
                     /translation="MDVLRLYFGALAGQRRGVLVLLGWSVLEGVPAFLSGRLVSLAVDR
                     GFAVGQPLVGVGWLLVFAAVAVLGGFGLRQVFRHLGAVIEPMRDALVGVVVRGVLHDGA
                     THRRQPDASAVARITRHVEVVRDATAGVLVQARALLVTTTAALVGLVTTVADLAWLVVS
                     PVVLALVLFGLLLPSLARRQREQVMSDERSAEVAGTVLVGIRDVVACGAEQEAGDEVSA
                     AIDRQADASVRVAWANSLRGLVIAVGGFAPLALLVVAAPAKVASGQLTAGAVLGAVVYL
                     STSVQPALRRLADTTSTVVLRLMVALRRLSEAAPAPAPPAGDEVPTGNAVSLRGVTFGW
                     GEHAEPVVRDLDLDLAPGDHLAVVGPSGIGKSTLAGLLTGLMAPREGTAALGGVPVHLV
                     RPAVRHRRIALIPQETYLFTGTVRENLALFTPDATDAELLAAVDAVGATDLVAGLGGLD
                     GALGHAGSGMSAGEAQLLAVARVFACPAEIVILDEATSHLDPTAEAKVERAFAERGGVL
                     VVIAHRLSSALRAKRVLVMDGGPALVGEHTDLVRTSPAYAELMQAWLPAESARPSY"
     gene            complement(16451..16954)
                     /locus_tag="CLV43_RS41590"
                     /old_locus_tag="CLV43_118127"
     CDS             complement(16451..16954)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074684.1"
                     /locus_tag="CLV43_RS41590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118127"
                     /product="DUF3145 domain-containing protein"
                     /protein_id="WP_106195641.1"
                     /transl_table=11
                     /translation="MSTRGSTSGVVYVHSSPSAVCPHVEWAISGTLGERVDLRWAAQPA
                     APGQLRAECAWTGDVGTGSKLVSALRAWPMLRFEVTEDPSDGVDGERFCFAPVLGLWHA
                     RTSANGDIMVSEDQLRALALRSRGGESFAHGVDELLGAAWDDALEPFRRAGDGAPVTWL
                     HRVG"
     gene            17389..18672
                     /locus_tag="CLV43_RS41595"
                     /old_locus_tag="CLV43_118128"
     CDS             17389..18672
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099001.1"
                     /locus_tag="CLV43_RS41595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118128"
                     /product="hypothetical protein"
                     /protein_id="WP_106195643.1"
                     /transl_table=11
                     /translation="MRLIRLGASPSDVGKDVRAALTTWGVGDHVLGGVALLGVQPPDSP
                     RAVEAVVVLPRGVVVVVGVDLPDPAVRLEAPLTGKWKIDGWPLNRPDGEVSPAAEALEA
                     ALAVGARIQAMRAEPLPVTTVVAVGPYVGHVDQPTADLNRGVRVLHPKPTSLLAAVREL
                     ATGDRPCSVEHAARLLAVLSPSGGPPSTRDLLAEGFADEIAVDLSSAQTMLLPKVPARG
                     SAATTAVKGTVARLPKAVPYLAAGLLCLLVVVGIVVASNSGGAPQTAPAVTSESMPTTV
                     VVDGANFTPRGTGRDTDCAGHAFGDVQAWLAAHPCTALHRAQYETAAGDRHIAVAVAEI
                     ALADVPSAQELHTVAAAAGSGGVTTLLKDGKAWPGGPRSFDRSAFASTTKGTQVRLAQA
                     VWLDGDSSATDADLVAAAERALRLPTGQ"
     gene            complement(18680..19063)
                     /locus_tag="CLV43_RS41600"
                     /old_locus_tag="CLV43_118129"
     CDS             complement(18680..19063)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800158.1"
                     /locus_tag="CLV43_RS41600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118129"
                     /product="hypothetical protein"
                     /protein_id="WP_106195645.1"
                     /transl_table=11
                     /translation="MTRGVVVTATAASLWCAFVLAATFRHAAPPSAMAVYVPAVLVLPV
                     VLLTLRRVGKDALLALALVPRALLVLGLLVALFGWLFACGALHGQPGTERLGTFAGVVL
                     VLHAVFGLVAVGLVKVDENPHLR"
     gene            complement(19116..20498)
                     /locus_tag="CLV43_RS41605"
                     /old_locus_tag="CLV43_118130"
     CDS             complement(19116..20498)
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800157.1"
                     /locus_tag="CLV43_RS41605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118130"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_245887419.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.4e-51, bitscore:
                     167.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSDEFDVIVIGGGPVGENAAGRTAAGGLRTALVEAELFGGECSY
                     WACMPSKALLRPGHVLAAAKRMPGVPVGDRLDAAAVLERRTRFTSDWDDSGQVQWAEGA
                     GIVPVRGRGVITGEREVTVGDRVLTARRAVVVATGSVPRVPSLPGLSDVPHWSSREATS
                     AKEVPASLVVLGGGVVGVEMAQAWAVLGAEVTLVISQDRPLAKFEDFVGDLVADGLRAD
                     GVTIHTGAKASSVSEVDGGVELTLGDGTKVVAEHLLVATGREPATRDLGLEAFGIEAGK
                     ALPVDDTGRVSGVDWLYGCGDVTGRAPLTHQGKYAARAVGSAILADARDPEPWTVTVAT
                     ADHAAVPQVVFTDPEVAFVGRTADQARAAGLTVKVVDLDIAVAGSSLHADGYKGKARMV
                     VDEDKRTLVGVTFVGQDVAEMLHAATIAVVGEVTVDRLWHAVPAYPTISEVWLRLLESY
                     GL"
     gene            complement(20535..21140)
                     /locus_tag="CLV43_RS41610"
                     /old_locus_tag="CLV43_118131"
     CDS             complement(20535..21140)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800156.1"
                     /locus_tag="CLV43_RS41610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118131"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_106195647.1"
                     /transl_table=11
                     /translation="MRRQPVQQRGAATVTAILDACSTLLNEQDYDDITTARIVELAGVP
                     IGSFYQYFPDKRSVVHALALRGMEEYLAEVDVLFDGGTLSDDWREAMGQVVGVYMRMLV
                     DVPGFGRIRFSDLLDGHRLDSSVDQYELMAERLAELFVDRFGAPGDGPVRLTFRMAAQT
                     ADSLFTLASQLSGEDRFHVLRKADEVISTMLAEVLDPS"
     misc_feature    21294..21309
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.71"
                     /tool="antismash"
     misc_feature    21466..21479
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.04"
                     /tool="antismash"
     gene            complement(21656..22333)
                     /locus_tag="CLV43_RS41615"
                     /old_locus_tag="CLV43_118132"
     CDS             complement(21656..22333)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098997.1"
                     /locus_tag="CLV43_RS41615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_118132"
                     /product="hypothetical protein"
                     /protein_id="WP_106195649.1"
                     /transl_table=11
                     /translation="MRDLRREFVRLCRCVVTGPRWQLVIVVVVSAWSCAWILGQVGGTP
                     TSPLAVLRGPLDWAGVPIGWLDAVGGWIRDRQDVLAGLAVVAGLLWAVTTERGRLAAPT
                     GWFAVLVAAEAIGYAAAVHRALLTLAVVIGVFAVLSYVGRRAFVVDRIALLPRGVLHAG
                     ATAVTLSAVVPLIAPGLLLAGLVRPYVTRPPRLDPTRPHIPRQRSHPVGNPVGNPAEEH
                     RSA"
ORIGIN
        1 gagaccgaac tggtcaacac ctcgttcggc gacaactacg agaagtcctg gacgcgtgcc
       61 ggcgacgtcg cccacacctt caccatcgcc gtgaaggcct cggacggcaa ccagtacaac
      121 tactccaaga cgctcaaggt cgaggcgtgc gtgaagccca ccgcgccgag cacgaccacg
      181 accgtctcga agcccagcac gccggcggag agcaccccgc cgtccaccga ggtgaccacc
      241 agcacgacgg agtcgtcctc ggagaccgtg cccgtgacgt ccaccacccc ggtcgggagc
      301 ggtggcggtg agggtgaggc cactccgccg ctggcctcca ccggtgcttc gcccggctgg
      361 ctgctgctgt cgggcctcgg cctcgtcggc gcgggtgccg cggcgctggt cgtggtgcgc
      421 cgcaagcgcg ccgcctagtt ccaccgcacg accccgtcag ggcgtccccg cactcgcggg
      481 gacgccctga cggctttcct gtgcgcacaa cgccacgagg gccgtccccc gcgaagcggg
      541 acggccctcg tggcatcgcc ggggagctac tcgccgggcg tgatgggcat gcccgcgggc
      601 ggcgtcgggg cgtccgacgc catctgctgc gcggtcgcgt ggcgacgcgc gcccgccgag
      661 accggctcct gcgagcggcg cggcgcgggg gcggtgcggg ccgcctcgtc ctgcacgcgg
      721 gtcagccagc cctcccagcg ctgctgcatg gggcggacca ggccgccgcc gacgccgatg
      781 atgacgacac cggccaccgt ggcgagcacg gcgatcagca ccggcatggt caccgagacg
      841 gcgatgccga gctggttgag ggccgcgatg acgcccagcg ccatgatgaa gccgtaggca
      901 gccgtgccga gcatccgggt gtacgaacgg ccgcccaggg cgccggtcac caggccgcgg
      961 acggccttgc cgatcgccga ggcgacgagc accagcacca gcgcgaccac gatgcgcggc
     1021 aggtaggcga tcacgtcgtt gagcagctcg ctcaccgcgt tgccggtgcc gaacacgccg
     1081 aacgccatct gcagcgcgat cagcagcacg aagtagtaga cgagcttgac gatgagaccg
     1141 gacgcgtcca cgggcgactg cgccgtcatc gcgccgaggc cggacctctc gaccaggcgg
     1201 tcgaagccga cgcgcttcag caggaagccg accgccttcg acagcgcctt ggcgatgaac
     1261 caaccgacca ccatgacgag cgcgaagccg agcagcttcg gcacgaacgt ggcgatcatg
     1321 gcccaggcct gtccaagacc ttcggtgatc tgggaaccca cgacgccctc ctaactttct
     1381 tcgtagcttg tcgactgacc gggaaatggt ttcccgaacg ttgaccaccc ggcaattcgg
     1441 cgcacgagca cgaaagggtg accgattggc gtttcccgcg gactccgttc acagtggacg
     1501 gaccggtggg gaccggggag agggaaccgc ccggcgcagc agctcgcgcc gggcggtttt
     1561 cgtcaacggg ccagtcgctc ggcgagcccc gcggtgtcca ggaaggagcc ggccgggcgg
     1621 gtcgacggcc gcgccgggtc gggccggggg tcgccggggc aggtcgagga gctcggcggc
     1681 agcaccccgt cgaccaggta gtggtcgacc accgcgtcca cgcaggcgtt gccgctgttg
     1741 tagacgccgt gcttgccctc gtccagcacg gtgagcaggt tgtcgcccag cctgctcgcc
     1801 atcgcgggcc cgccctcgta ctgggtctgc gtgtcgccct cggcctgcac gaccaggccc
     1861 accgggtagc cgtcgcgctt gagcgggacc atcggtccgg gcggggtgaa cgagcggaag
     1921 gtgcacgcgg tcggggcggc gcgcagcacg ccgaagccgt aggggtagcg gtcgcggaac
     1981 acccgcatgt cctcgtagta ggtctccagg tcgcgcggcc agtcggcctc gcaggtgatc
     2041 gtggtgaaga cgccggactt gagctccccc ttggcggagg cggcgaacct ggcgctctgc
     2101 tcggcggcgg cctgcggcgt ggtgcccgcg ccgccgttca gcccgccgac cacacccgcc
     2161 aggtcggtcc acagtggacg gtagcgggag ccgacgccca cggcggcgtc gaactcgctg
     2221 cgggtgtgcg cgccgaccgg gtcgagcgcc agcctcgccg acgtccgctc gatggtggcc
     2281 agcacctcgg ggccgctgcg gccgagcccg aacacgtcgt cgtgctccgc ggcccactcc
     2341 gaccacagct cgacgttgcg ccgggtggcg acggcctgcc ccttggcctg ctggcgccac
     2401 agccactccg ggtgcaccga ggagtccagg acgctgcggt cgagccggta ggggaacagc
     2461 gacccgtaca cggcgccgag gtaggtgccg taggagtagc cgaggtagct gatccggggc
     2521 tcgccgagca cctcgcggat cacgtccagg tcccgcgctg tgttggcggt gttgacgaac
     2581 cgccggatgc cgcccgccga ggcctggcac gcgtcctcgg cggcccgcgc ctccgccgtc
     2641 cacttcgcga actccgagtc cggcggccgc gagtcggtcg tggtgatctc cggcaccgcc
     2701 cggcaggtga gcgcggtcga gccgccgacg ccccgcggat cgaacccgat caggtcatag
     2761 gacttggcca gcgcggtcgt ggagaggaag gcgggcatcc gcagtccgga ccctccggga
     2821 ccgccggggt tggccaccag gacaccgcgc cgcagctcgg tcgccttgcg cctgctgacc
     2881 gcgagcgaga tccggtcgag gccggggtcg gcgtagtcca gcggcacgac gaccgaggcg
     2941 cactccaggt cgccctggca cggcgcccag gtgagcgtct ggttgtggaa ctccgccaac
     3001 gggtccggcg gtgttgtccg ggccgacacc gccggcgacg aggtcgcgag gaccacgagc
     3061 accgcaagac ccactgggac aagccttcgc aagaccggac ctcccgttga tgagcgcacc
     3121 ggtaggaagg tagggcgccg cgccccggtc cgagcgcttc tgtcacccgt tgcggtgatc
     3181 tcctgaccgg acgtgcgatc gttgtcggta tgaccagctc agccggtgct gaggggcagc
     3241 aggcctggcc cgagctgtcc cgcacgacgt tgcgcgacct cgaacgcgcg tcgggcgacc
     3301 tggccgcgtc cagcgtgtcg gagatggagc gcaggctgcc gtggttccgg cggatgcccg
     3361 ccgaccagcg cgcgagcgtg ctgctgctca tccagaacgg ggtcgccggg ttcgtgtcct
     3421 ggctggacga cccgcgccag gccatccggc tgaccgcgga ggcgttccgg tccgcgccca
     3481 aggacatctc gcgctgggtc agcctgcggc agaccgtgga gctggtgcgg atcgcgctgg
     3541 agctcttcga gcagcagctg cccaggctcg cggccgacga cgccgaacgg gcgcggctca
     3601 ccgagggcgt gctgcgctac gggcgcgaga tcgccttctc cgcggccacg tcgtacgcgg
     3661 ccgccgccga ggcgcgcggc gcgtgggacg cccggctgga ggccctcgtc gtcgacggga
     3721 tcgtgcgcgg ggacgccgag gagtcgctgc tgtcccgcgc ggccgcgctc ggctgggacc
     3781 cggccgcgga ggcgaccgtg ctggtcggca acccgccgtc ggacgacccg cccgcggtcg
     3841 tctacgaggt gcgcagccgg gccgcgcgca gcgcccggcc ggtgctgctg agcgtgcagg
     3901 gctcgcggtt ggtcgtggtg ctgggcggcg agaccgacga cggcgacgtg ctgggcaaga
     3961 tcgccgaggc gttcggcgac ggcgcggtgg tcgccgggcc gacggtggcc agcctcgccg
     4021 aggcgcaccg cagcgccagc gacgcgctgt ccgggctgcg cgcggtcgtc ggctggccca
     4081 ccgcgcccag gcccgtgcgg tcgctcgacc tgctgccgga acgggcgctc gcgggcgacc
     4141 cggaggccga gtggcagctc gtcgaccgga tcgccaggcc gctggaggag gccagcgggt
     4201 cgctgctgga gaccgtggac acgttcctgg aggtcggcgg ggtcctggag acgtgcgcgc
     4261 ggaagctgtt cgtgcacccg aacaccgtgc gctaccggct gcgccgggtc accgagctca
     4321 ccgggcgcaa cgcccacgac gcgcgcgacg ccctcgtgct gcggatcgcg ctgtcggtcg
     4381 ggcggctggc gaaggcgcgc ggtctgtggt gatgtgccgc cgaatgtcgc tttgcgcccg
     4441 tcggatgtga ccgacaccgc accggttggt gggtgacaca ggtcgctctg tacaacacgt
     4501 gctgacgttc ttcggacatg tcgcggcaat ttttgtggaa accctacaac tacgcaccct
     4561 ggacttcgtc gacaacggca tcactgcgga cgcccgcgac cgtgttcagt tgcactgtga
     4621 tcgcactcct cgcccccgga cagggttcgc agactcccgg catgctcgcc ccgtggctcg
     4681 agctcgacgg ggcgcggcag cgggtcgacg cctgggccga ggccacgggc ctggacctgg
     4741 tccgcctggg cacgaccgcc gaggccgagg agatcaagga cacctcgatc acccagccgc
     4801 tcgtcgtggc gctggcgctg ctcgcgttcg aggagctgcg ccggcgggtc gagctgccgt
     4861 cggacaccat catcggcggg cactccgtcg gcgagctggc cgccgccgcg atggccggtg
     4921 tgctcagcgc cgacgacgcc gtggcgctgg ccgccgtgcg cggggccgag atggccgccg
     4981 cgtgcgcgct gcacccgacc ggcatggccg ccgtgctcgg cggcgacgag gccgaggtgc
     5041 tggcccgcct cgccgagctg gagctcacgc ccgccaaccg caacggcgcg ggccagatcg
     5101 tcgccgcggg cccgctggac gcgctcgaca agctggtcga gtcgcccccc ggcaccgcga
     5161 agatccgcaa gctgcaggtc gcgggcgcgt tccacaccgc cttcatggcc ccggccgagg
     5221 aagcgctgcg cacccgcgcg gcggacgtcg tcgcgaacga ccccgccctg ccgctgctct
     5281 ccaacgccga tggcacgatc gtcaccgacg gcgcggacgt gctgcgccgg ttgatctccc
     5341 aggtgacccg ccccgtgcgg tgggacacct gccaggccac cctggccggg cacgccgtgc
     5401 acgcggtcgt cgaactgcct cccgcgggcg cgctgacggg tctggccaag cgagagttga
     5461 agggcacccc caccttggct ttgaagactc cggagcacct cgacaaggtc gccgagctcc
     5521 tggccaccgc ggaggccggt cgatgacctc catcaagctc ccggcggcgc tgtccgggac
     5581 gcgcatcctc ggcatcggga gctaccagcc cgagacgatc gtcaccaacc acgacctcgc
     5641 gaaggtcatg gagacgtcgg acgagtggat ccgcgaccgc gtaggcatcg tgagccgccg
     5701 gttcgcgggc aaggacgaga agctgaccga catggccgtg gaggcgggcg cgaaggcgat
     5761 cgccgactcc ggcctcaccc ccggcgacgt cgacgccgtg atcgtcgcga cctgcaccat
     5821 gccgtcgccg atcccgaacg ccgcggcgca ggtcgccgag cgcatcggcg tgaccgccgc
     5881 gcccgcgttc gacgtgaacg ccgcgtgcgc cggcttctgc tacgccctgg cgaccgcgtc
     5941 ggacatggtc cgctcgggca gctcccgcaa cgtgctggtg atcggcgccg agaagctcac
     6001 cgactgggtg gacccgacgg accgctccac cgcgatcatc ttcgccgacg cggcgggcgc
     6061 cgtcgtggtc ggtcccggcg acgagccgag catcggcccg gtcgcctggg gcagcgcggg
     6121 cgagctggcg gacaccatcg ccatcgccga ccgcaactcc tcgatccacc aggagggcca
     6181 ggcggtcttc cgctgggcga ccacccagat cgcccccgtg gcgatccgcg cggtcgagct
     6241 ggcgggcgtc gagctgtccg acgtggacgt gttcgtgccg caccaggcga acctgcggat
     6301 cgtcgaggcg atcgcgaagc ggttgcgcag caagggtgcg cgtgaggaca tggtcatcgc
     6361 gcgtgacatc gtggagtccg gcaacacgtc ctccgcctcg atcccgatgg cgctcgacca
     6421 catgcgggcg gcaggcgaga tctccagcgg ggacgtggtg ctgctcatgg gcttcggagc
     6481 gggcctgtcc tacgcgggac aggtcgtccg gtgtccgtga gcggaccacc catcagtgcc
     6541 ccggcgggac gggactgccg tccccgccgt ccacagcaag aaggaaggga ctttcagtga
     6601 gcaacgagga catccagaag gggcttgccg agatcgtcga agaggtcgcc ggtgtcgcag
     6661 ccgacgacgt gacggtcgag aagtcctttg tggacgacct ggacatcgac tcgctgtcca
     6721 tggtggagat cgccgtgcag gccgaggaca agttcggcgt gaagatcccg gacgacgagc
     6781 tggccaacct caagaccgtg ggcgatgcgg tgacctacat cgctagcaag gcatgaccac
     6841 aaatcacgac gtcgtcgtca ccgggctggg tgcaaccacc ccgctcggtg gcgatgtcgc
     6901 caccacctgg gacgcgctgc tcgccggtcg cagcggcgtg tcgaccaaca acatggactg
     6961 ggtcgagcgc ttcgacctgc cggtgcggat cgccgcgcag ctcgcggtcg accccaccga
     7021 ggtgcttccc agggtcgagg cccgcaggct ggaccgcagc gagcaggtgg cgatgatcgc
     7081 cgcccgcgaa gcgtggaagg acgcgggcca cagcgacgac accgtcgaca aggaccgcct
     7141 ggcggtcatc gtcggcaccg gcatcggcgg cgccatgacg ctgctgaacc aggacgacct
     7201 gctcgaggag cacggcctgc gcaaggtctc gcccctcacc gtgccgatgc tgatgccgaa
     7261 cggcccggcc gcgcacgtgg gcctggagtt caaggcccgc gccggggtgc acgccccggt
     7321 gtcggcctgc gcgtcgggcg ccgaggcgct cgcgtgggcg tggcggatga tccgcaccgg
     7381 tgaggccgac gtcgtggtgg ccggaggcgc ggaagcgtgc atctgcgcca tcccggtggc
     7441 cgggttctcg caggcgcgca cgatgagcac ccgcaacgac gagccggaga aggcctcgcg
     7501 gcccttcgac accggccgcg acgggttcgt cctcggcgaa ggcgccggga tcatggtgct
     7561 ggagcgcgcg gacttcgccg ccgcccgcgg cgccaaggtc tacggacggc tcgccggcat
     7621 cggcaccagc tccgacggct accacatcac cgcccccgac cccgagggca ccggacaggc
     7681 acgggcgatc agcgcggccc tgcggaccgc gggcctcgac ccgagcgacg tcggccacgt
     7741 caactgccac gccacgtcca ccccggtggg cgacgtcgcg gagacggtcg ccatccgcaa
     7801 ggccatcggc gaccacccgg tgctgaacgc ccccaagggc gcgctcggcc acctgctggg
     7861 cgcggccggg gccgtggagg ggatcgtcac gctgctgtcg atcagggacg gcgtgatccc
     7921 gcagacgctg aacctggaca acctggatcc ggcggtggag ctggacgtgg tggcgggaga
     7981 gccccggaag gtgaagctgg aggcggcggt gaacgacgct ttcgggttcg gtggtcacaa
     8041 cgtggcgttg gcgttcacgc ctgcgtaggt gggttgggtt ttgggtttga gtttcgggta
     8101 gtgcggtccg ggagcccggt cgtgcgctgg tctgttcttg gggtgcgtcg ggtggcgtgg
     8161 tccgggggtg gggtggcgtg gggccgggtt tttggtgttc tgggggtgcc gctgtgggct
     8221 cgcccggtat gggtggctcg gtggggctca cccggtgtcg ctaccgcgga ctccggggta
     8281 tcgctacagc tgtctccggg tgcggtcggc ttgacttggg gccccttttt tgggcttcgt
     8341 cgggcgaaaa agggcaggtg gtagagcctg cccgccgacc aattttaagc ccaaaaaccc
     8401 caagtcaagc cgaccgcacg agcggacgag catgctcgct tccagcgtcg tcgggggctt
     8461 gtgggttggt ccagcgtcgc tggtagggcg gcttatcgct tccagcattt gttgggtggg
     8521 ttgctcgctt ccagcgtcgt caggtagctg gctcgctgct tccagcgtcg ttgggtggat
     8581 tgtgtgcggc ttccgcgctc cacccctccg cgctccaccc ctccgcgctc cacccctccg
     8641 cgctccaccc ctccgcgctc cacccctccg ccttccccct tcgcgccgtg gcctgtcagc
     8701 aggcttcgaa ctggggggtg tagccctcgg ggccggtgtc tacgcggagg ctgtcgtctt
     8761 cgttgcgcaa ggggtagacg acgtgccagc ggatgcagtc ctcggggagt tcgacggggg
     8821 ccttggtggg gtcttggacg ctgatgaagc tgatcatgac gcgcaggcgg tcggtcgagg
     8881 cggcttcgat gcgttggacc atgacggtgc cgtcggtggt ggagtcgtag tcgcgttgcc
     8941 acttggcctc ggtgaaggga cggctgaagt ccttggtgac gacggtgcgc caggtctgga
     9001 agtcgcggga gttgatggcg tcgaagtagc gctggagcac ctccttgacg cgggtgccgt
     9061 cggggtggaa cgaggcgtcg acgctgaggg tgacggcggg gtcgccgggc tggttggagc
     9121 gcgggacgga gctcgacgtg gagctggtgg acggggcggt gccggaggcg ccgggactcg
     9181 cggggcgctg gtagaggtcg cgggcgagga agccgcccgc gacggacgcg gcggccacca
     9241 ggacagcggt cggcaggacc cagcgggcgc gggggcgccg gtgctcgtcg gtcgtcacgt
     9301 ttcgagcgtg ccacaaccag caggtgcacc gggaaccggc tgtgcgctac cgggtgacac
     9361 ggatgagact tttattccac tcgaacgtgt gacgaatgtg cacaattgtt ctgcgattat
     9421 cgcgtgagga atcctcataa caaccgatcg ggggacattg ataatcctat cgtggccatc
     9481 gacagggtcg atggcgtgac aagttcccac gttcgcgagt tgcagagtgc gacatcgatc
     9541 aggagtcgaa cagaacaggc cggcagagcg acctggggaa atgcggttcc gtaccgctga
     9601 atggacaaac ccggtgcggc ggaaggcccc attcgcgcgg ttgccccacc tgtccgatga
     9661 gcacgcaggg tgatgacccc caaaacgcgg gtcgtcattc gaacgagaag cggaaatacc
     9721 gctggtagag cggggtacgg ctttgtgaac tgactagttc cgtttagttg gggccgccgt
     9781 cgttacggga gcgttacacc ctgacaaaca tcgcgatcgg gtgaattcat tcgacaatgg
     9841 tcgacagcgc gtcgtaaatg cgagggtagg tcactgaatt cggcccctcc aacggtccaa
     9901 gacgcgtcgc ccgactggcg gattggattc actgtgccaa ctgtgcggaa atatgccggt
     9961 cccgataacg agttgggaac atccaaggga gggaattccg gtggatctcc gctatgaggc
    10021 ttactgcttc gcggatcgtc acttctacga cgtccagagc catgcggaaa cctccgtcga
    10081 cgatttctcc cgcgagctcc ccgagctccc cgacggctgg tcgcagggcg agaagaacat
    10141 ctggcggcac ctgcacccca agggtgcggt gctggcgaag cagggctgga agatccacgt
    10201 gtcggcgacg gtggcgaacg cgggtcgcgt cctcaaggcg acctacgact actgcgtcga
    10261 gcaccggatc tccttcaagt acctgcgcac ccagtcgatc gtgctggccc gcaactcgaa
    10321 gtacgccccc cgcgaggcca gcggcaagct ggtcgcgatc tacccggccg acgaggtcga
    10381 gctggagcgg atcctggtcg agctgtccga gctgctcgac ggcgaggatg gcgcgtacat
    10441 cctcagcgac ctccgctacg gcgccggtcc gctctacgtg cgctacggcg ggttcgtcga
    10501 gcagtggctg gagcgggacg gcaagcaggt gctggcgatc gagggcccgg acggcgagct
    10561 cgtgccggac cagcgcaagc cgaacttctg ggtccccgag tgggtcgagc tgcccgcgtt
    10621 cctggtgccg cacctggccg cccgcaacgg cggcgacccg gacgagttcc cctacgacgt
    10681 ggtgcgctcg ctgcacttct ccaacggcgg cggcgtgtac ctggcgaccc gcaaggccga
    10741 cggcgccgag gtggtgctga aggaggcccg gccgcacgcc gggctggacc gcgacaacac
    10801 cgacgccgtg gtccggctcg accgcgagtt caagatcctg accaggctgg acgggatccc
    10861 cggcgtgccc caggtgtacg accgcttcac cgtgtgggag caccacttcc tggccatgga
    10921 gtacatgccg ggcaggccgc tcgggcagtg gctgggcatg cactacccgt tgacgcacaa
    10981 cggggtcggc gacgagcgga tcaccgagta cacggcccgc gcgctcgccg tggtggaccg
    11041 ggtcgaggcc acggtcgagg cgctgcacca gcgcggtgtg gtcttcgccg acctgcactc
    11101 cctcaacatc ctgctcgacg acgacgacag catgtcgctg atcgacttcg agctctcctt
    11161 ccacctcgac gccccccgca ggcccacgct cggcgcgccc ggcttccagg cgccgcccga
    11221 ccgcgagggc ttcgagatcg acgagtaccc gctggccgcg ctgcggctgt ggctgttcct
    11281 gccgctcaac gaggtgctgg agctggcacc gtcccggctg cggtcgcacc tcgacttcat
    11341 ccggcgccgg ttcggcctgt ccgaggagta ctgcgctcgg atcgagcgcg tcctcacccc
    11401 ccgcggcgag gtgccgcccg caccggccag gacgtcgctc gacgagcgcg acccggactg
    11461 gcgtgcggtg tgccgggaca tcacgaccgc gatcctggcc agcgcgaccc cggagcggac
    11521 cgaccggctg ttccccggcg acatcgagca gttcgaggtc ggcggcgcgt gcttcgccta
    11581 cggcgcggcg ggtgtgctgc acgcgctgca cgtcagcggg cagggccggt tccccgagta
    11641 cgagcagtgg ctccaggact cggtgcggcg cgacccgccg aagcagcccg gtttcttcac
    11701 cggcgcgcac ggcatcgcct acgtgctgga ggagttcggc caccaggagc tggcgaccga
    11761 cctggtcacc gagtacgcga agacgctgcc cggcacggtg gaccacgggc tcggcagcgg
    11821 gctgtcgggc gtgggcctca acctgctgca cttcgcggac gtccgggagg acgacgactt
    11881 cctcggccag gccatcggga tcgccgaccg gctgggcttg gagctccagc tcgccgaggg
    11941 gcccggtccc aaggcgaagg ccggtctgct gcacggctgg tcgggcccgg cgctgctgtt
    12001 cctgcggctg ttcgagcaca gcggcgaccg cggctggctc gacctggccg ggcaggcgct
    12061 ggaccgcgac ctcgcggagt gcatggtcgc cctcgacggc tcgacgcagg ttcgcgacgg
    12121 cggttaccgc acgctgccct acgtcgaggt cggcggcgcg ggcatcgcgc tggtgctcaa
    12181 ccagtacgcc cggcacgcac ccgacgccga gagcgtcacc cgacttcccg acctgctgcg
    12241 cggcgccgcg ggcgagttcg tgatccaccc cggcctggtg ctcggccgga tgggtctgct
    12301 cgcgacgttg gcgcaggccg tgcggcgaca gcccgacccg gtgttcgagc aggcgatgcg
    12361 acgacacctg gccgcgctcg cgtggcacgc cgtcccctac cgggacgggt tggcgttccc
    12421 cggcatgcag ctgcggcggc tgtcgatgga cctcaacacc ggcggtgccg gtgtgctgct
    12481 ggcgctggcc tccgtgatgg acggggacgc ctcggtgctc ccgttcctcg gagccgcgcc
    12541 caccccatag acccccggtc ccgagtggcc ggtggagcag taaaccccga gaagttcgct
    12601 gaatgaggag caagacaatg ggattcatcc tcgacatgca ggagctcgag acccccgagg
    12661 ccccgtccaa cgccatggca agcggccacg gcggcggcgg cagcacgacg gcctccagcg
    12721 cgagcctgct gctgccgtgc agccactcct ccgcgagcct ggtcctctgc taggtcttcc
    12781 cgcagaggtc gggtgagcgg cacaagcgaa gtgtgccgct cacccggtga cacaagggtc
    12841 cgacggcagc gaccgaccac gaatcggtgc ggctgccgtc gggcccttct cccatgatgc
    12901 gcccacctct caccggaggg aacagcgatg gcccaaccgg gcgacgcgct gctggtcgaa
    12961 gcggccgacc acgaccgccg ttggctgctc ctcgtgctca acgccgcgct ggccacgacc
    13021 gccgggctgg tgctgcccgc ggcgctggcg aacaccgtcg acatggcgct ggcgggcagg
    13081 ctggacccca cgaccgtgct gtggctggtg tcgttggtgt ccgtggaggt cgtgggcgac
    13141 gcgatcggcg tcgtcctggc cgcggcgatc accgccaggg tcaccgcctg gctgcgccac
    13201 cgggtgtccg cccacctgct cgggctcggc cacccgtccc cgttcgcggc gggcgacgcg
    13261 gtcagccggg tgaccggcga ctccgccatc gcgggcggca tctcggtgat cctgatcgtg
    13321 ctggtcgtga cggtcgtcag ctcggtcggc gcggtggtcg cgctggcgct gatggactgg
    13381 cggctggccg cggtgttcct gctcagcgtg ccgctggcga tgctgctggt gcgcacccac
    13441 atgcggctca ccgccgacga cgtggccacc taccagaacg tgtcgggcga gctgtccgcc
    13501 cggctgctcg acgccgtgtc gggcctgcgc acgatcgccg tgtccggcac cgccgagcag
    13561 gagtcgcgcc gggtgctgcg gccgctgccg acgctcgccg cggcgggcat cgggatgtgg
    13621 cgcacccagg cgaagatgat ctggcgggcc gggctgctgc tgcccgccgt ggagctggcc
    13681 gtgctgaccg ccgcgggttt cggcgtcgtc gccggtcggc tgaccatcgg cgacctgctg
    13741 gcgacgctgg ggtacgtggc gctgggcatg ggcgtggtcg gccagctgcc cgcgctgacg
    13801 acgttcgcca ggacccgcgc gagcgcgacc cggctggtcg aggtgctcga caccccgctc
    13861 ccccgccgcg acgcgccacc cgccccggcg tccgcgggcg acctggagct gcacaacgtg
    13921 acggtcgagg gcgcgctgcg cgacgtgcac ctgcggatcc ccgcgggcac gttcgtcgcg
    13981 gtcgtcggcc ggtccggcgc ggggaagtcc gcgctggcgg ccgtgatcgg cggactgtcc
    14041 actccggaca ccggtgaggt gcgccgcgac ggcgaggtcg gctacgcctt cgaacggccc
    14101 gcgctgctcg gcgcgaccgt cggcgagtcg atccgctacg gcgccgacgc gggcaagcgg
    14161 cgggtgcgcg cggcgtgcgt ggccgcgcag gtccacgacg tggtggtgcg gctgccccag
    14221 ggctacgaca cgcccatggc cgacacgccg ctgtccggtg gtgaggcgca gcgcctcggc
    14281 ctcgcgaggg ccctcgcgcg cgaccccgac gtcctcgtgc tcgacgacgc caccgccagc
    14341 ctggacatgg tcaccgaggc ctccgtggac aaggcgatcg aggccgccct acccggtcgc
    14401 accaaggtcg tcgtcacgca ccgcgccgcc accgcccgcc gcgccgacct cgtggtgtgg
    14461 ctggtggacg gcgaggtgcg cgccaccggt ccgcacgagg cgctgtggct tgaccccgac
    14521 taccgggccg tgttcaccgg gggcgacgtc tgatgcacgc gttctccgac aaaggactgt
    14581 tgatcgaagg attgctggtt cgggcctacc gccccggagg ctggatctga tggacgtgct
    14641 gcggctgtac ttcggagcgc tggccggaca acggcggggt gtgctggtcc tgctcggctg
    14701 gtcggtgctg gagggcgtgc ccgccttcct gtccggacgg ctcgtgtcgc tggcggtcga
    14761 ccgcgggttc gccgtcgggc agccgctggt cggtgtcggg tggctgctgg tgttcgccgc
    14821 cgtcgcggtg ctcggcgggt tcgggctgcg ccaggtgttc cggcacctcg gcgcggtgat
    14881 cgagccgatg cgggacgcgc tggtgggcgt ggtcgtgcgg ggtgtcctgc acgacggcgc
    14941 gacgcaccgg cggcagcccg acgcgagcgc cgtcgcgcgg atcacccggc acgtcgaggt
    15001 ggtgcgcgac gccaccgcgg gtgtgctggt gcaggcccgc gcgctgctgg tcacgacgac
    15061 cgcggcgctg gtcgggctgg tgaccacggt ggcggacctg gcgtggctgg tggtgtcgcc
    15121 ggtcgtgctc gcgctggtgc tgttcgggct cctgctgccc tcgctggccc ggcggcagcg
    15181 cgagcaggtg atgtccgacg agcggagcgc ggaggtcgcg ggcacggtgc tcgtcggcat
    15241 ccgcgacgtc gtcgcctgcg gtgccgagca ggaggcgggc gacgaggtgt cggccgcgat
    15301 cgaccggcag gcggacgcgt ccgtgcgggt cgcgtgggcg aactccctgc gcgggctggt
    15361 gatcgcggtc ggcgggttcg cgccgttggc gctgctggtg gtggccgcac cggcgaaggt
    15421 ggcgtccggg cagctcacgg ccggtgcggt gctgggtgcc gtggtgtacc tgagcaccag
    15481 cgtgcagccc gcgctgcggc ggctggccga caccacgagc acggtggtgc tgcggttgat
    15541 ggtcgcgctg cgcaggctct ccgaagcagc gcccgccccc gctcccccgg cgggtgacga
    15601 ggtgccgacc gggaacgcgg tgtcgctgcg cggggtgacg ttcggctggg gtgagcacgc
    15661 cgagccggtc gtgcgcgacc tcgacctgga cctcgcgccg ggcgaccacc tggccgtggt
    15721 gggtccgagc gggatcggga agtccacgct ggcgggcctg ctgaccgggc tgatggcccc
    15781 gcgcgagggc accgcggcgc tgggcggggt gcccgtgcac ctggtgcggc ccgcggtgcg
    15841 gcaccggcgg atcgcgttga tcccccagga gacctacctt ttcaccggga ccgtgcggga
    15901 gaacctcgcg ctgttcacgc cggacgcgac ggacgccgag ctgctggcgg cggtcgacgc
    15961 ggtgggcgcg accgacctcg tcgccgggct gggcgggctg gacggcgccc tcggccacgc
    16021 gggctcgggg atgtcggcgg gcgaggcgca gctgctcgcg gtggctcggg tgttcgcgtg
    16081 cccggccgag atcgtgatcc tggacgaggc gacctcgcac ctcgacccga cggccgaggc
    16141 gaaagtggaa cgggcgttcg ccgaacgcgg cggcgttctc gtcgtgatcg cgcaccggct
    16201 gtcctcggcg ctgcgggcga agcgggtgct cgtgatggac ggcggtccgg cgctggtggg
    16261 cgagcacacc gatctggtcc ggacttcacc cgcttacgcg gaactcatgc aggcgtggct
    16321 tccggccgaa agtgcgcggc cttcgtatta gcgccgctaa ttccgagggg tgctcataaa
    16381 attctcacga acgctcgacg gacgggaacc cccgcgattc cacaatgcgg gggcacccgt
    16441 ccgcgaagtc tcagccgaca cggtgcagcc acgtcaccgg cgcgccgtca ccggcacggc
    16501 ggaatggctc cagcgcgtca tcccacgcgg cgccgagcag ttcgtccacg ccgtgtgcga
    16561 aggactcgcc accgcggctg cgcaaggcga gcgcgcggag ctggtcctcg gacaccatga
    16621 tgtcgccgtt ggcactggtc ctcgcgtgcc acaggcctag cacgggggca aagcaaaagc
    16681 gctcgccgtc cacgccgtcg ctcggatcct ccgtcacctc gaatcggagc atcggccacg
    16741 cccgcaacgc ggacacgagt ttactgcccg tcccgacgtc gccggtccaa gcgcattcgg
    16801 cgcgcaactg ccccggcgcc gcgggctgtg ccgcccaccg gaggtccact cgctcaccga
    16861 gggtgcccga gatagcccac tcgacgtgcg gacagaccgc agacggcgac gagtggacgt
    16921 agaccacgcc actggtgctg ccacgggtgc tcacagctga cctccgctac tcgacgaggg
    16981 acgtcttccc ctacgacctg tcgaaacgga cgatcaagcg aattcccgct gcggccattc
    17041 tgcctgctgt cgcagctgtc cgccagaaga accagcgcga tcaccaccct ggcggcccag
    17101 atacaggact tttgacccta aagtgcgtgc agacggccca aatcatgaac cgctcgggca
    17161 aaacccgaga tctccgcgtg atcttcgcgt gatcatccgg cgaccgcgcc gccgcgcccc
    17221 ctccgggcag gtgcttcaca cggacggtag tgcttgcgcc ccaaggagta gcgactgccg
    17281 aggcgcgcgc cggtgacgac cgacacggcg gtggcgcgcc gcgagcctgg cgatcggtcc
    17341 ggtcccagcg cgactaccgt gtcgcaccgt gtggatgagg gtgatcacgt gcggttgatc
    17401 cggctggggg cgtcaccgtc ggacgtcggc aaggacgtgc gcgcggccct gaccacctgg
    17461 ggtgtggggg accacgtgct cggcggcgtc gcgctgctgg gcgtccagcc cccggacagc
    17521 ccccgtgcgg tcgaggccgt cgtggtgctg ccgcgcggtg tcgtggtcgt cgtgggggtg
    17581 gacctgcccg acccggcggt gcggctggag gcgccgctga ccgggaagtg gaagatcgac
    17641 ggctggccgc tgaaccggcc cgacggcgag gtgagcccgg ccgccgaggc gctggaggcc
    17701 gcgctcgcgg tgggcgcccg gatccaggcg atgcgcgccg agccgctgcc ggtcaccacg
    17761 gtcgtcgcgg tcgggccgta cgtcggccac gtggaccagc cgaccgcgga cctcaaccgg
    17821 ggcgtgcggg tgctgcaccc caagccgacc tcgctgctgg ccgccgtgcg cgagctcgcc
    17881 accggcgacc ggccgtgctc ggtggagcac gcggcgaggc tgctggccgt gctctccccc
    17941 agcggcggtc cgccctcgac gcgggacctg ctcgccgagg ggttcgccga cgagatcgcc
    18001 gtggacctgt cgtcggcgca gacgatgctg ctgccgaagg tgcccgccag gggctcggcg
    18061 gcgacgaccg cggtcaaggg gaccgtcgcc cggctgccca aggcggtgcc ctacctcgcg
    18121 gccgggctgc tgtgcctgct ggtcgtcgtc gggatcgtgg tggcgtcgaa ctccggcggg
    18181 gcaccgcaga ccgcgcccgc ggtcacctcg gagtccatgc cgaccacggt ggtcgtggac
    18241 ggcgcgaact tcaccccgcg gggcaccggc cgcgacaccg actgcgccgg gcacgccttc
    18301 ggcgacgtcc aggcctggct ggccgcgcac ccgtgcaccg cgctgcaccg cgcgcagtac
    18361 gagacggcgg cgggcgatcg gcacatcgcg gtggccgtcg ccgagatcgc gctcgccgac
    18421 gtgcccagcg cgcaagagct gcacaccgtc gcggccgccg cgggctccgg cggcgtcacc
    18481 acgctcctca aggacggcaa ggcgtggccg ggcggcccca ggtcgttcga ccggtccgcc
    18541 ttcgccagca ccaccaaggg gacgcaggtg cggctggccc aggccgtgtg gctggacggc
    18601 gactcctcgg cgaccgacgc cgacctcgtc gccgcggccg agcgcgcact gcgcttgccc
    18661 accgggcaat gacgtccggt cagcgcaggt gcgggttctc gtccaccttc accagaccca
    18721 cggcgacgag cccgaacacc gcgtgcagca ccaggaccac accggcgaac gtgccgaggc
    18781 gttcggtgcc cggctgcccg tgcagcgcgc cgcaggcgaa cagccagccg aacagcgcga
    18841 cgagcaggcc gagcaccagc agcgctctgg gcaccagcgc caacgccagc agggcgtcct
    18901 tgcccacgcg ccgcaacgtg agcaggacga ccggcagcac gaggaccgcc gggacgtaca
    18961 ccgccatcgc cgagggcggc gccgcgtggc gaaacgtcgc cgcgaggacg aacgcgcacc
    19021 agagcgacgc cgctgtcgcg gtgacgacga cgcccctggt cacgtcctca gcttagatac
    19081 ccggtccgac ggggacagcc agcgcgtagg ccgggtcaca gcccgtagga ctccagcagc
    19141 cgcaaccaca cctcgctgat cgtcgggtaa gccgggaccg cgtgccacag ccggtccacg
    19201 gtcacctcgc cgacgacggc gatcgtggcg gcgtgcagca tctcggcgac gtcctgcccg
    19261 acgaacgtga caccgaccag tgtccgcttg tcctcgtcca cgaccatgcg cgccttgccc
    19321 ttgtacccgt cggcgtgcaa cgaggacccg gcgacggcga tgtccaggtc gaccaccttc
    19381 acggtgagcc ccgccgcgcg cgcctggtcg gcggtgcggc ccacgaaggc gacctcgggg
    19441 tcggtgaaca cgacctgcgg gacggcggcg tggtccgcgg tcgcgacggt gaccgtccac
    19501 ggctcggggt cgcgggcgtc ggccaggatc gcggagccga ccgcgcgggc ggcgtacttg
    19561 ccctggtgcg tcagcggtgc gcggccggtg acgtcgccgc agccgtacag ccagtccaca
    19621 ccggacaccc ggccggtgtc gtccacgggc agcgccttgc ccgcctcgat cccgaacgcc
    19681 tccaggccga ggtcgcgggt ggcgggctcg cggccggtgg cgacgagcag gtgctcggcc
    19741 acgaccttcg tgccgtcgcc gagggtcagc tcgaccccgc cgtccacttc ggacaccgag
    19801 gacgccttgg ccccggtgtg gatcgtcacg ccgtccgcgc gcagcccgtc ggccaccagg
    19861 tcgccgacga agtcctcgaa cttggccagc ggccggtcct gcgagatcac cagggtcacc
    19921 tcggcgccca gcacggccca cgcctgcgcc atctcgacgc cgaccacacc gccgccgagc
    19981 acgacgaggg aggctggcac ctccttggcc gaggtcgcct cgcgggagga ccagtgcggc
    20041 acgtcggaca gccccggcag cgacggcacg cgcggcacgc tgccggtcgc gaccaccacg
    20101 gcgcggcgcg cggtcagcac tcggtccccg acggtcacct cgcgctcgcc ggtgatgaca
    20161 ccccggccgc ggacgggcac gatgcccgcg ccctcggccc actggacctg accggagtcg
    20221 tcccagtcgg aggtgaaccg ggtgcggcgc tcgagaacgg ccgcggcgtc cagccggtcc
    20281 ccgaccggca cccccggcat ccgcttcgcg gccgccagca cgtggccggg ccgcaggagc
    20341 gccttgctcg gcatgcacgc ccagtaggag cactcgccgc cgaacagctc ggcctccacc
    20401 agcgcggtcc gcagacctcc cgcggcggtc cgccccgccg cgttctcccc caccgggccg
    20461 ccaccgatca cgatcacgtc gaactcgtcg ctcgtcaccg gaccagccca caccaccgca
    20521 tggggaaggg caagtcagct cgggtcgagc acctcggcga gcatcgtgga gatgacctcg
    20581 tcggccttgc gcagcacgtg gaagcggtcc tcgccggaga gctgggaggc gagggtgaac
    20641 aggctgtcgg cggtctgcgc ggccatccgg aacgtcagcc gcaccggccc gtcgcccggc
    20701 gcgccgaacc ggtcgacgaa cagctccgcc agccgctcgg ccatcagctc gtactggtcg
    20761 acgctcgagt cgaggcggtg cccgtcgagc aggtcgctga accggatccg cccgaaaccc
    20821 ggcacgtcga ccagcatccg catgtacacg cccacgacct ggcccatggc ctcgcgccag
    20881 tcgtcggaca gcgtgccgcc gtcgaacagg acgtcgacct cggccaggta ctcctccatg
    20941 ccgcgcagcg cgagcgcgtg cacgacggac cgcttgtccg ggaagtactg gtagaacgag
    21001 ccgatcggca cgcccgccag ctcgacgatc cgcgccgtgg tgatgtcgtc gtagtcctgc
    21061 tcgttcagca gcgtcgagca ggcgtcgagt atcgcggtca cggtcgccgc cccgcgctgc
    21121 tggaccggct gccgacgcat gactctggcg agtcgtcctc tggcgggatt gtcaggcacg
    21181 tgtgcatcct taaaagttac ggaccagtag gaccagcgcg agtttctctg gacacttggc
    21241 tcggggtacc gcattttcac ctggtcgcca agagattaac tcgtgagagg ccaaccgtga
    21301 gtcattatcg cattcctcgg agcgtccgca ccctgcgcca cctgcgcatg cgtgatccaa
    21361 atcgatagaa atccacccgt atcctccccg cagaccgctc gtttggcccc cattacaggg
    21421 gctgccgata aagcacgatc ggccgatgtg aacctttcgg gtgaacgagc gaaagttctt
    21481 atcgaccccg gagaggcctt cgttacagag aacccgctca cgccaccctg gatcgcgtcc
    21541 ccctatcggg tgacttccga gcgatcgccc gttcgggcgc ccggacgggc acgcgtccag
    21601 ggcttagagg acgcgcgggc gcccggtcgc cgtgcgcggg ggcggttccc ggcggtcagg
    21661 cggagcggtg ctcctcggcg gggttcccga cggggttccc gaccgggtgg gagcgctggc
    21721 gcgggatgtg cggccgggtc gggtccaacc tcggcggcct ggtcacgtac ggccgcacca
    21781 gccccgccag gagcagcccc ggcgcgatga gcggcaccac ggcggacagc gtcacggccg
    21841 tcgcgcccgc gtgcaggacc cccctgggca gcagcgcgat ccggtcgacc acgaacgccc
    21901 ggcgcccgac gtaggacagc acggcgaaga cgccgatcac gaccgcgagg gtgagcagcg
    21961 cccggtgcac ggccgccgcg tacccgatcg cctcggcggc gaccagcacc gcgaaccagc
    22021 ccgtcggcgc ggccagcctg ccgcgctcgg tcgtgaccgc ccagagcagc ccggccacga
    22081 ccgcgagccc ggcgagcacg tcctgccggt cgcggatcca gccgccgacc gcgtccagcc
    22141 agccgatcgg gacgcccgcc cagtccaggg gcccgcgcag gacggcgagc ggcgaggtgg
    22201 gggtcccccc gacctgcccg aggatccagg cgcacgacca ggccgacacg acgaccacga
    22261 tcaccagctg ccacctgggc ccggtcacca cgcaccggca cagccgcacg aactcccgcc
    22321 gcagatccct cacccgccca gagtggcgtg gtcgggccac ccgcggtggg ggttcacccc
    22381 gctgccccgc cggtaccgcc cttcaggggt aacccgatca cgcggcgtgc cgccagcgcg
    22441 gcgccgatgt gctggaggtc ctgcggccgg gccgggtcca gcccggtcag cgcgaccacc
    22501 cggcgcagcc ggtagtccac ggtgttcggg tggatgtgca gccgggccgc
//
