LOCUS       NZ_PVTF01000018        25091 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Umezawaea tangerina strain DSM 44720 Ga0180964_118, whole genome
            shotgun sequence.
ACCESSION   NZ_PVTF01000018
VERSION     NZ_PVTF01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Umezawaea tangerina
  ORGANISM  Umezawaea tangerina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Umezawaea.
REFERENCE   1  (bases 1 to 166491)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 166491)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Expected Final Version            :: No
            Genome Coverage                   :: 86.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003002815.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:47:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,483
            CDSs (total)                      :: 9,418
            Genes (coding)                    :: 9,322
            CDSs (with protein)               :: 9,322
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 20 of 97
            Pseudo Genes (incomplete)         :: 83 of 97
            Pseudo Genes (internal stop)      :: 2 of 97
            Pseudo Genes (multiple problems)  :: 8 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:41:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 18866
            Orig. end                         :: >43957
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVTF01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..>25091
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..>25091
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..>25091
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:>15091](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..>15091
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(630..1967)
                     /locus_tag="CLV43_RS41050"
                     /old_locus_tag="CLV43_11817"
     CDS             complement(630..1967)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230065.1"
                     /locus_tag="CLV43_RS41050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11817"
                     /product="MFS transporter"
                     /protein_id="WP_245887394.1"
                     /transl_table=11
                     /translation="MTSSAATTTRGPGALLLLGLSLGYFLVLLDTTVITVALPAVGADL
                     GGGLGALQWVSNGYPLAFAALLLTAGAWSDRHGARRVFLVGLCAFAVLSAATSVAWSVG
                     VLIGLRALLGVAGALLVPTSLALVATAWTEPAARARATGVWAALSGTGLVAGPVAGGLL
                     TDAFGWRSVFLVNVPVALAAVVVVARRAPETPRSSGRGTDVTGQVSAVVALGALTYGLV
                     RARWSAPDVLGALAVAVLAAVVFVLAQRRPETGPVAPMLPPRLFADRTFGWGLAAGAIV
                     NFGLSGVLFVLSLSWQGTRGYSASAAGLAFLPLTIPTALNPVLTGRLVARTGPKVPAVA
                     GFLLMAAGTAAQAATTDPLLAALGLALLGFGVSFAIPSLMTAVLGAVPKDLAGVGGGAV
                     NAARQTGAVLGVAVLGTLLPAGPRTALATAAAVLVVGAVIAGAAVE"
     gene            2055..2948
                     /locus_tag="CLV43_RS41055"
                     /old_locus_tag="CLV43_11818"
     CDS             2055..2948
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004562433.1"
                     /locus_tag="CLV43_RS41055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11818"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_106195416.1"
                     /transl_table=11
                     /translation="MELRHLRSFSVVARTLNLTRAAEELHYAQSSVTEQIQALEAELGT
                     PLFDRTGRRLRLTAAGGRLVDYAHQVLALVEQARAAVDEQPDEPTGALVLGALETLCAH
                     RVPALFTDYRTRWPKVGVTVEQGDRGYLYDAVRRGAVDVSLTFGAAPTDPALASEVLAH
                     DRLVVVVPPGHRLAALDEVGAEDLRGLGFLATPPGCGFRAMLEDALLGDVVIEAEVASL
                     AAMCGCVIAGSGCALVPETAARDHVAAGRLTAIPLRGKHSRTAVTMTWQRRSAGRPSVA
                     ALLVSARAAFARQPVA"
     gene            complement(2954..3715)
                     /locus_tag="CLV43_RS41060"
                     /old_locus_tag="CLV43_11819"
     CDS             complement(2954..3715)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099098.1"
                     /locus_tag="CLV43_RS41060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11819"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_106195418.1"
                     /transl_table=11
                     /translation="MTKALIDYGRLLDVLAAEAETLASAAEGQRPERQVPACPGLNLGE
                     TARHVGSTYRMTLSWLRDGRQPVTWQQNPAPGEDLADFVRAGVEPLLDELAAHEAEDLC
                     GTWWPEEPNYGFWARRLAHETTVHRMDVQAAAMIPLDPVADDVVADGVDEVLSLWFVHR
                     LNVLGVRGTRDGVVAVRTAGRVWLASSGQRGSTSWRATPEEAEPADADVTGDPIKVYQW
                     LWGRISDREVEVNGDHDAIAQLWALLRLATK"
     gene            complement(3712..4155)
                     /locus_tag="CLV43_RS41065"
                     /old_locus_tag="CLV43_11820"
     CDS             complement(3712..4155)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671609.1"
                     /locus_tag="CLV43_RS41065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11820"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_106195698.1"
                     /transl_table=11
                     /translation="MSASIDFPKPSRTRIPVPVPLPQPPAAAVELLEHAREGIAEAERA
                     DQAADRFAVAYLAALRAGAAVLALRGRPHRGRAKPTSVWVLLAGIAPELAEWAAFFASA
                     SSTRAAVQAGITRVVTARSADDLVRQAAQFTALVDRIMHEART"
     misc_feature    4139..4155
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.58"
                     /tool="antismash"
     misc_feature    complement(4260..4275)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: strong, score: 27.38"
                     /tool="antismash"
     misc_feature    4261..4274
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 24.78"
                     /tool="antismash"
     misc_feature    complement(4261..4274)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.95"
                     /tool="antismash"
     gene            4363..4863
                     /locus_tag="CLV43_RS41070"
                     /old_locus_tag="CLV43_11821"
     CDS             4363..4863
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419640.1"
                     /locus_tag="CLV43_RS41070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11821"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_245887396.1"
                     /transl_table=11
                     /translation="MSELAHPGMQKVAAALTEAGHHEAAQGIRVLEDAVRTAAQAAEAV
                     DVPVGAIANSLVFTAIRADVPAPLLVLTSGAHRADTDLLAELAGADRIERATPDFVREH
                     TGQVIGGVSPIGHPSRIMTFVDTDLEQYPVVWAAGGHPHAVFPTTFAGLVELTGGTPAR
                     VAR"
     gene            4860..5426
                     /locus_tag="CLV43_RS41075"
                     /old_locus_tag="CLV43_11822"
     CDS             4860..5426
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332697.1"
                     /locus_tag="CLV43_RS41075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11822"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_106195422.1"
                     /transl_table=11
                     /translation="MTAAPSPRTERLVELTPQELNARLHEALRLYVTAMNYPPGTVEQR
                     APMWLAHMLREDWRCVAALDDRDELVGIGYGYRGSVGQWWHEQVRRGLTAVAGAQAVDE
                     WMDDYFELTELHVLPRAQGRGLGEALLRELLGGVPTSHVLLSTPEGPSNAWRLYRRVGF
                     VDVLRHYQFTGDPRPFAVLGRELPM"
     gene            complement(5842..7536)
                     /locus_tag="CLV43_RS41080"
                     /old_locus_tag="CLV43_11823"
     CDS             complement(5842..7536)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943816.1"
                     /locus_tag="CLV43_RS41080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11823"
                     /product="DUF885 domain-containing protein"
                     /protein_id="WP_106195425.1"
                     /transl_table=11
                     /translation="MASSSAGVHDISNRFVIDYVALDPLAATQLGLPGGEDQLTDYSPE
                     GHAARHELEVRAIREVSAAEPADKSESDAKAVFLERGSVSVDLYEAGRVESDLNVLASP
                     VQSLREIFDHMPTDTPEQWAVVARRLAAMPDAVTKLRAGLSYAADKGRVSALRQVTKVA
                     DQCDTWSGRRGGRSFFANLVEGAQKGGTQVDAALRTDLEKGATAAAEAYGDLAAFLRDD
                     LAAKAPVKDAVGEEAYRLASRYFVGSRLDLAEAYEWGWEEFTRIESEMKQIVGRIKPGA
                     TLAEAAAALDADPRYLVQGQAGLQSWMQQLSDKALLDLRDVHFELPDELMRLECRIAPP
                     GGGVGAYYSGPTPDFSRPGRMWWSVPADRETFSTWRELTTVYHEGVPGHHLQVATAVYN
                     SDKLNDFQRLFCWVSGHGEGWALYAERLMRELGYLDDDGNLLGMLDAHLFRAARVIIDI
                     GMHLELEIPKGTGFHEGERWTPELGLEFMLTRTITDPSHVHDEIDRYLGWPGQAPSYKI
                     GERLWLAARDDARTRHGSAFDLKRFHKEALEMGAMGLDTLRERLAEL"
     misc_feature    7576..7596
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.93"
                     /tool="antismash"
     gene            7654..8307
                     /locus_tag="CLV43_RS41085"
                     /old_locus_tag="CLV43_11824"
     CDS             7654..8307
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099092.1"
                     /locus_tag="CLV43_RS41085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11824"
                     /product="DUF3153 domain-containing protein"
                     /protein_id="WP_106195428.1"
                     /transl_table=11
                     /translation="MSRARVLLLPVFLLLAAFSLTGCVRLHAAMAVSEDDRVSGEIIAA
                     TPPTADNDPGPQLRVPSELASRVTTKPYRVDAYAGTQLFFNGLTFDEVRTLSAATSSSS
                     SRYTLNFRRSGDLVTMSGSVDLTQVPIDRADIQVKISFPGGVVNTNGREEDEGTIAWSP
                     KPGQASMLTATVQYAGADSEGFFGWVMLVGALTGGAALIVVVLALVAHRRSLVA"
     gene            complement(8386..9000)
                     /locus_tag="CLV43_RS41090"
                     /old_locus_tag="CLV43_11825"
     CDS             complement(8386..9000)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV43_RS41090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV43_11825"
                     /product="hypothetical protein"
                     /protein_id="WP_106195431.1"
                     /transl_table=11
                     /translation="MPTFDENFKREAEAKRARSEAHKRGLADDFAAKVRSAEPVISRVC
                     RDMAALLRVAKVPVANDDGWSLPDLPSVLATPPRYVAADRFGKRWDLRLATKSWATLTP
                     DAALLSDRYKSSVRKERGAERDARVRAVHQAIAVSDVNALAATTLEADFGMTHRLVLDR
                     NTRVLFVCAGDQGARPTVLPFSEYGNRAATALVHAWEHRGR"
     gene            complement(9011..9895)
                     /locus_tag="CLV43_RS41095"
                     /old_locus_tag="CLV43_11826"
     CDS             complement(9011..9895)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0006555 - methionine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332694.1"
                     /locus_tag="CLV43_RS41095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11826"
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="WP_106195433.1"
                     /transl_table=11
                     /translation="MTTVVERLHGRGPVFSVEFFPPRDSADELVLWRAIRELEPLDPAF
                     VSITYGAGGSSRDFTIRTTGRVAQETTLVPMAHLTAVDHSVAELRNVIGWYAAVGVRNI
                     LAVRGDPPGDPNGEWVAHPDGLTYAEELVRLCRELGDFCVGVAAFPYGHPRSGDVDTDT
                     EYLVRKLRAGADFAIAQLFFQPEDFLRLRDRVDALGCDTALLPGLMPLTTPRTLAKTIE
                     LSGAPVPPSVARRLDPFVDDPKGFRKAGVDLVTEMGDRLLAEGVPGLHFYTLNRSKATR
                     EVVARLGLVPARA"
     gene            10001..11080
                     /locus_tag="CLV43_RS41100"
                     /old_locus_tag="CLV43_11827"
     CDS             10001..11080
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099089.1"
                     /locus_tag="CLV43_RS41100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11827"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_245887398.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 9e-46, bitscore:
                     149.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPELLHPLDLALPTHVDEALATYLADRRTLGALMDENFTGAVD
                     GLAAFVLSGGKRIRPTFAWWGWRAAGGDPEGPLAESVLTAVSSLELIQACALVHDDLMD
                     ASEVRRGKPTVHIAFAQEHRDRRWLGEPERFGLAAAVLIGDIALAWADDMLFAAGLPTD
                     ALQRLSLPWRDMRTEMLAGQYLDVLTQARGDSSPDAALRIDRLKTAAYTVERPLHMGAA
                     LGGGSPELIDGLRRFGADIGVAFQLRDDLLGVFGDPAVTGKPAGDDLREGKRTLLVALG
                     MEYGADVLHKALGNPELDVETVDAVRDALVGVGAVDAIEDRITELTTSALAALDAAPVT
                     APAGDRLAELAVSATKRTY"
     gene            11083..12603
                     /gene="crtI"
                     /locus_tag="CLV43_RS41105"
                     /old_locus_tag="CLV43_11828"
     CDS             11083..12603
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637666.1"
                     /locus_tag="CLV43_RS41105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11828"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_106195436.1"
                     /sec_met_domain="DAO (E-value: 3.7e-17, bitscore: 56.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLPGRTDHVVVVGAGLAGLSTALHLLGTGRSVTVVERDATPGG
                     RAGRLDLDGYRIDTGPTVLTMPELVEDALAAVGESLADRLDLVPVDPAYRARFADGTSL
                     DVHADAEEMEAEVRRFAGADEAAGYRRLRTWLTELYRVEKDSFIGANFDSPADLLGPSL
                     AKLAALRGFGRLGPSIARFLRDERLQRVFSFQSLYAGVPPRRALAAYAVIAYMDTVAGV
                     HFPRGGMRALPDAMAGAVADAGAALRYRTTVAWLERIGSRVTAVRTTQGERIPCDAVVL
                     TPDLPVAYRLLGKAPRRPRAVRWSPSAVVLHAGTTRTWPELAHHTILFGGAWDRTFDEI
                     TSTGRLMSDPSLLVTQPTQGDPSLAPPGRHLNFVLAPVPNLEVGPVDWERVGPAYRDEL
                     LRTLEARGLTGFEASVETSHLVTPRDWADMGLAAGTPFSAAHTFGQTGPFRPRNLVDGV
                     ENVVLAGCGTTPGVGVPPVLISGKLAAQRVAGTPLGALRARNRTAIVT"
     misc_feature    12677..12692
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.73"
                     /tool="antismash"
     misc_feature    12694..12711
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.33"
                     /tool="antismash"
     misc_feature    12696..12711
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.68"
                     /tool="antismash"
     gene            12768..14294
                     /gene="mptB"
                     /locus_tag="CLV43_RS41110"
                     /old_locus_tag="CLV43_11829"
     CDS             12768..14294
                     /codon_start=1
                     /gene="mptB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016696877.1"
                     /locus_tag="CLV43_RS41110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11829"
                     /product="polyprenol phosphomannose-dependent alpha 1,6
                     mannosyltransferase MptB"
                     /protein_id="WP_146175112.1"
                     /transl_table=11
                     /translation="MASTPSLPRSSAASAQQAPTADTRTPSEPTGIPIRTILLGVAGVT
                     LISLGGAGAGAVLKTDPLLTDLSLSWVRYGHGHDLATALLYAGLGLVIWAWVRLGRMVH
                     HRLVGTAAVLIAIVAWTLPLLLSPPLFSKDVYSYLAQGQLALHGFDPYRVGPAALPSPL
                     SDNVSWVWQNTPAPYGPLFILIAKTVVWATGASVIGGVVLMRLVLAAGLALMCWSLPGL
                     TRHLGGRPAVALWLAGANPLMLVHLIGGGHNDILMVGLMAAGVLLVLDRRHVLGIVLVA
                     LAVAVKATAAVALPFLVLVWAARLDGSQRARLAKAIGGGVAVFVAVFAVCSLVAGVDLG
                     WIPALSSSSTIVNWLSLPSAVGDFVYTLVSLVVKVEPGVFMTVARGAGSLLLLYIAWRQ
                     WRAAEDGGPNAIRHAALTMLAVALLSPATLPWYFSWPLVLGAGLAWTATSLTAVVFFSS
                     VLLLVTFPNGDTALYSWGYLALTAAVSALAAVSLTRPDPLELSSRYGPRP"
     gene            14435..>15091
                     /locus_tag="CLV43_RS41115"
                     /old_locus_tag="CLV43_11830"
                     /pseudo=""
     CDS             14435..>15091
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012705.4"
                     /locus_tag="CLV43_RS41115"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11830"
                     /product="phytoene/squalene synthase family protein"
                     /pseudo=""
                     /sec_met_domain="phytoene_synt (E-value: 1.8e-89, bitscore:
                     292.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 9.1e-52,
                     bitscore: 169.4, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHALYGFARWADEIVDSSSSAGRGAQLDELEHQFDDQLSGRPVDH
                     PVLAALADTITRYRIDRGLFADFLASMRMDLEVDEYADLDALGRYMHGSAAVIGLQLLP
                     VLGTVAPRAEAEAGAAALGVAFQLTNFLRDVGEDLDRGRLYLPLDVLTAFGVDRDRLLA
                     CRDTGRSDLRVRRALAHLAAHTYAVYREAETAVALLRPVSRPCVTTALTLYREILD"
     gene            complement(15220..15585)
                     /locus_tag="CLV43_RS48225"
                     /old_locus_tag="CLV43_11831"
     CDS             complement(15220..15585)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657740.1"
                     /locus_tag="CLV43_RS48225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11831"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_211304808.1"
                     /transl_table=11
                     /translation="MSAIPAAADVLAPDLEVLDLPEVADRLGLPITRVHQLLRDGQLLA
                     ERRAGVLVVPADFIAAGGVVKGLFGTITVLRDSGYSTDEILTWLFTEDETLPGSPIEAL
                     RGDRGREVKRRAQALAF"
     misc_feature    complement(15590..15607)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.03"
                     /tool="antismash"
     gene            15686..17737
                     /gene="pknB"
                     /locus_tag="CLV43_RS41120"
                     /old_locus_tag="CLV43_11832"
     CDS             15686..17737
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419659.1"
                     /locus_tag="CLV43_RS41120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11832"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_245887401.1"
                     /sec_met_domain="Pkinase (E-value: 7.1e-50, bitscore:
                     163.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGGLLEHRYRVDRVLARGGMSTVYRGVDTRLDRAVAIKVMDPQF
                     SADRSFVARFEQEARAAARLHHPGIVAVHDQGVDRGEPGGEHVFLIMELIEGGTLRDLI
                     SERGTLSTPLALSVLEPVLSALAAAHQAGLVHRDVKPENVLIGLDGRVKVADFGLVRAV
                     ASVSTTSDSTILGTVAYLSPEQVATGASDARSDVYSAGIVLYEMLTGVTPYLGDTPISV
                     AYRHVNEDVPAPSTIVPGIPAELDQLVVRATRRDPAQRPADAAAFLAEAERVRAALGVP
                     RMAVPAPAPGQHDQTVRVRPVQAPRDSAAAELTMPVLAAAGAGAATISHRVPGTPGGAG
                     GGPQGTVALNRTAYQPPPAAPPPPKPAAKKRVPRKTAAEVYEEERKRNKRRFILWAGLV
                     ALLAVLVGVTAWWMGSGRFTTVPGLIGAEEETAVVLLKDASLKSTFTQEASDTVPKGKV
                     LRTDPAEGTEKLRGDAVKVYISLGKPVVPIVRPGSESADVENDIKKSGLKASLDANADV
                     FSDTVTKGKVVTSKPAPGTEVKLNSTVTIVLSKGSEPKPVPDLTGKTKDEAFAELTSLG
                     FEPVEGKGEPSGNVEGGKVVRTDPPANTTIPAGSSKKVSVILSTAKAQVTVPKVEGQKV
                     KDAKKSLEDLGLQVEVLFNRNSNSKVLNQSIPPNTKVDKGTKITLIAP"
     gene            complement(18064..19452)
                     /locus_tag="CLV43_RS41125"
                     /old_locus_tag="CLV43_11834"
     CDS             complement(18064..19452)
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800237.1"
                     /locus_tag="CLV43_RS41125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11834"
                     /product="3-deoxy-7-phosphoheptulonate synthase class II"
                     /protein_id="WP_106195445.1"
                     /transl_table=11
                     /translation="MNWTVDVPVDTLPELPPLPPEMRSRLDDALARPAAQQPEWPDPEQ
                     VRRVRAVLESVPPITVPAEIDRLRANLAEVARGDAFLLQGGDCAETFADNTEPHIRANI
                     RTLLQMAVVLTYGASVPVVKVGRIAGQYAKPRSSNIDALGLPSYRGDIVNSLVATPEAR
                     IPDPSRLVRAYANASAAMNLLRAMTSAGMADLHRLHDWNKDFVRTSPAGERYEALAAEI
                     DRGLRFMSACGVNDMSLHTTEIFASHEALLLDYERSLLRLDTTNDEPRLYDLSSHFLWI
                     GDRTRQLDGAHIAFAEMLSNPIGLKIGPSTTPEMAVEYVERLDPRNEAGRLTLISRMGN
                     GKVRELLPGIVEKVTASGHQVIWQCDPMHGNTHEASTGYKTRHFDRIVDEVQGFFEVHR
                     GLGTHPGGIHIELTGEDVTECLGGAQEISDADLAGRYETACDPRLNTQQSLELAFLVAE
                     MLRS"
     gene            19578..20585
                     /locus_tag="CLV43_RS41130"
                     /old_locus_tag="CLV43_11835"
     CDS             19578..20585
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022646.4"
                     /locus_tag="CLV43_RS41130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11835"
                     /product="DUF2891 domain-containing protein"
                     /protein_id="WP_170156240.1"
                     /transl_table=11
                     /translation="MDDGTAARLLATAVANVQRDHPVHWTHMVSSDAELVPQRTLHPVF
                     AGSYDWHSCVHQTWLAVRLVRLRPDLEGSAEAVAVLDSLLTPEKCEVEAEFFRGPWGKH
                     WERPYGWAWLLVLDAELKTWGSETAQRWSTALAPLADVLRDRFLTWASTARLPMRVGTH
                     GNTAFATSMVLDAARAVDDVELTEVCVEAALRWHREDVGYGGFEPDAADFLSPALVESD
                     LMRRVLDADEFAAWFEAFLPNLDEARWKVLREPVPVDDPADPYGSHLSGLALSRAWNWQ
                     AVAEALPAGHRYRDLALTSAEAHREAGWRYVFGHGYAAEHWLGTFAAYLDLGAY"
     gene            complement(20637..21662)
                     /locus_tag="CLV43_RS41135"
                     /old_locus_tag="CLV43_11836"
     CDS             complement(20637..21662)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004558616.1"
                     /locus_tag="CLV43_RS41135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11836"
                     /product="6-phosphofructokinase"
                     /protein_id="WP_106195451.1"
                     /transl_table=11
                     /translation="MRIGVLTGGGDCPGLNAVIRAVVRKGVEVHGWDIVGFRNGWQGPI
                     EGLTKSVGLADVEDILTRGGTILGSSRTNPYKVDGGVDKIRKVLSDEGVDALIAIGGED
                     TLGVAKRLTDDGIGVVGVPKTIDNDLGATDYTFGFDTAVHIATESIDRLRTTAESHHRA
                     LVVEVMGRHAGWIALHSGLAGGANVILVPERPFSVEKVVNWVERRFEKQYAPIIVVAEG
                     AVPEGGAEVLHSGEKDAFGHVRLGGVGTWLAEEIAQRTGKESRAVVLGHTQRGGIPTAY
                     DRVLATRFGLHAADAVADGDFGVMVALRGTEIVRVKLSEATAELKTVPPHRLAEAEVFF
                     G"
     misc_feature    complement(21774..21791)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.58"
                     /tool="antismash"
     gene            complement(21800..22312)
                     /locus_tag="CLV43_RS41140"
                     /old_locus_tag="CLV43_11837"
     CDS             complement(21800..22312)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005465357.1"
                     /locus_tag="CLV43_RS41140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11837"
                     /product="polyadenylate-specific 3'-exoribonuclease AS"
                     /protein_id="WP_146175113.1"
                     /transl_table=11
                     /translation="MRFFYDCEFIEDGTTIDLISIGVVTEQGDEFYAVSTEFDPAKAGP
                     WVRNNVLNQLPPPSDKCWRSREKIKRDLLDFLGGPKAARDEVELWAWFAAYDHVALAQL
                     WGAMPALPRSLPRFTRDLRQRWDDVGKPRLPQPPADAHDALADARHNLARWKVIEQERR
                     KRGFPVA"
     misc_feature    22278..22296
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.22"
                     /tool="antismash"
     gene            complement(22335..23093)
                     /locus_tag="CLV43_RS41145"
                     /old_locus_tag="CLV43_11838"
     CDS             complement(22335..23093)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637556.1"
                     /locus_tag="CLV43_RS41145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11838"
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_106195457.1"
                     /transl_table=11
                     /translation="MLYWLMKHIFLGPLLKVFFRPRIIEGAENIPKEGGAILASNHLAV
                     SDSFFLPLKLSRRVTFPAKIEYFTGTGVKGWLQKAFMSGVGQVPIDRSSASAAQGALST
                     GVRILREGKLLGIYPEGTRSPDGRLYKGKVGVAWIALEAGVPVIPVAMFGTDKANPIGS
                     RMWKPTQISIKIGKPLDFSRYEGLSGDRFVLRSITDEIMYALMELTGQEYVDVYAAKAK
                     EDQAAAEAAVEVPGRPDAKSVDRVPETKAG"
     gene            23291..23752
                     /locus_tag="CLV43_RS41150"
                     /old_locus_tag="CLV43_11839"
     CDS             23291..23752
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099079.1"
                     /locus_tag="CLV43_RS41150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11839"
                     /product="hypothetical protein"
                     /protein_id="WP_106195703.1"
                     /transl_table=11
                     /translation="MDSRRDSTDGPEDVDAAFAEIVASLERDGMGANWPDPPDFDDPQD
                     EPVAAGIRPEGQPRVPTPDPDADDEDDNEHFVPPEPPPLPKLRAGTIAALAVILVGVAL
                     LFIPQLFGISTQLTVPAALVVLCAGVGWLVLRIRPDPPQDSGWDDGAVL"
     misc_feature    24030..24044
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    complement(24132..24146)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.54"
                     /tool="antismash"
ORIGIN
        1 gctacgcggc ccagggccac tacccggagc cgacggacag cgccgtcatg cagctcacct
       61 gctcaccggt gcacaacgac ccgccgaagt tcttccgccc ggtgttccgg ctggcctggt
      121 ggccgccgat gggccgggtg ctgcgcaggc tggccgaccg cgcgggcgtg cccgcggacc
      181 cgttgagctg gacgcggttg accggcccgc acttcggcaa ctcgatcgcg gtgctggagg
      241 tggacggacg gcaggcccgg ttcgtgctgg agtccgcgac acccgacggc aggggtctgg
      301 tcgaggtcgc gaacctgggc ctgccgcccg cctagcgcgg tggccacctt cctcggcggg
      361 catgtccgcg tctgggcgga actcctcggc aaggggggca ccgcgtcggg aacccgcccc
      421 cggtccgcgg ctcggcctcc gtcgagcggg atccgggcgg cgggccgtgg cgcggtgggc
      481 aggtagtcga tcttgaacgc ggtcgggcac ccggttttgt cggtacccgc cggtagaatt
      541 gacttcgggg gaccccctac cagcggtgga gggcatgggg ctccgatcat gacggtagtg
      601 gtggggtccg acagttccgc cgggttcggc tactcgacgg ccgcgcccgc gatcacggca
      661 ccgaccacga gcaccgcggc ggctgtcgcc agggcggtgc gcgggcctgc ggggagcagg
      721 gtgccgagga ccgcgacgcc cagcacggcg ccggtctggc gggcggcgtt gacagcgccg
      781 ccgccgacac cggccaggtc cttgggcacc gcgccgagca cggcggtcat cagcgacggg
      841 atggcgaacg agacgccgaa gccgagcagg gcgaggccga gcgcggcgag cagcgggtcg
      901 gtggtcgccg cctgcgcggc cgtgcccgcc gccatcagca ggaaccccgc caccgccggg
      961 actttcgggc cggtcctggc gacgagccgt ccggtgagga cggggttcag cgcggtgggg
     1021 atggtgagcg gcaggaacgc gagcccggcg gccgacgcgg agtagccgcg ggtgccctgc
     1081 caggacagcg acaggacgaa gaggacaccg gacagcccga agttgacgat cgcgcccgcg
     1141 gccaggcccc agccgaacgt ccggtcggcg aacagccgcg gcggcagcat cggcgccacc
     1201 ggaccggtct cggggcggcg ttgggcgagc acgaacacca ccgcggcgag gacggcgacg
     1261 gccagcgcgc cgagcacgtc gggggcggac caccgcgcgc gcaccagccc gtaggtcagc
     1321 gcgcccaggg cgacgacggc cgagacctgg ccggtgacgt cggtaccacg ccctgacgag
     1381 cgcggggtct ccggcgcgcg ccgcgcgacg accacgacgg cagccagcgc gaccggcacg
     1441 ttcaccagga acaccgaccg ccagccgaac gcgtcggtca acaggccgcc cgcgaccggc
     1501 cccgcgacca gtccggtgcc gctgagcgcg gcccagaccc ccgtcgccct ggcgcgggcg
     1561 gcgggctcgg tccaggcggt ggcgaccagc gcgagcgacg tcggcacgag gagcgcgccc
     1621 gcgacgccga gcagcgcgcg cagtccgatg aggacaccga ccgaccacgc gaccgaggtc
     1681 gccgccgaga gcaccgcgaa cgcgcacagg ccgaccagga acacccggcg cgcgccgtgg
     1741 cggtccgacc acgcccccgc ggtgagcagc agggcggcga aggcgagcgg gtagccgttg
     1801 gagacccatt gcagcgcacc gagtccgccg ccgaggtcgg cgccgacggc gggcagggcc
     1861 accgtgatga cggtggtgtc cagcaggacg aggaagtagc cgagggagag gccgagcagc
     1921 aggagcgcgc cggggcctcg agtggtggta gcggcggagg aggtcacgcg gtccagcctc
     1981 gtgacaggag gatcttcgcg gaagcgggga gttacgatgg cggcgatcgg ccggaccgat
     2041 gggagtgggg acccgtggag ctgcgccacc tccgctcgtt cagcgtcgtc gcccgcacgc
     2101 tcaacctcac ccgcgccgcc gaggagctgc actacgcgca gtccagcgtc accgagcaga
     2161 tccaggcgct ggaggccgag ctcggcaccc cgctgttcga ccgcacgggc cgtcgactgc
     2221 ggctcaccgc cgcgggcgga cggctggtcg actacgcgca ccaggtgctg gcgctggtcg
     2281 aacaggcacg ggccgcggtc gacgaacagc ccgacgagcc cacgggcgcg ctggtgctcg
     2341 gcgcgctgga aaccctgtgc gcgcaccggg ttccggcgtt gttcaccgac taccggaccc
     2401 gctggcccaa ggtcggggtc accgtcgagc agggcgaccg cgggtacctg tacgacgcgg
     2461 tgcgccgcgg cgcggtggac gtgagcctga ccttcggcgc ggcaccgacc gacccggcgc
     2521 tggcgagcga ggtgctcgcc cacgaccggc tcgtggtcgt cgtgccgccc ggccaccggc
     2581 tcgccgcgct cgacgaggtg ggcgcggaag acctgcgcgg cctgggtttc ctcgccacgc
     2641 cgcccggctg cgggttccgc gcgatgctgg aggacgcgct gctcggcgac gtcgtgatcg
     2701 aggccgaggt cgccagcctc gccgccatgt gcggctgcgt catcgcgggc tcgggctgcg
     2761 cgctcgtgcc cgagacggcg gcccgcgacc acgtggcggc cggacggctg accgcgatcc
     2821 cgttgcgggg caagcactcc cggaccgccg tcacgatgac ctggcaacgc cgctcggcgg
     2881 gcaggccgag cgtcgcggcg ctgctggtgt cggcgcgcgc cgcgttcgcc cggcaacccg
     2941 tggcctaggg cggtcacttg gtcgccagcc tgagcagcgc ccagagctgg gcgatggcgt
     3001 cgtggtcgcc gttcacctcc acctcgcggt cggagatgcg gccccacagc cactggtaga
     3061 ccttgatcgg gtcacccgtg acgtcggcgt cggccggttc ggcctcctcc ggggtggccc
     3121 gccacgaggt ggagccgcgc tggccggacg acgcgagcca gacacggccc gcggtgcgaa
     3181 ccgcgacgac accgtccctg gtgccgcgca cgcccagcac gttcagccgg tgcacgaacc
     3241 acaacgacag cacctcgtcc acgccgtcgg cgaccacgtc gtcggccacg gggtcgagcg
     3301 ggatcatcgc ggcggcctgg acgtccatcc ggtgcacggt cgtctcgtgc gccagcctgc
     3361 gcgcccagaa gccgtagttg ggctcctcgg gccaccacgt gccgcacagg tcctccgctt
     3421 cgtgcgcggc gagctcgtcg agcaggggct ccacgcccgc ccggacgaag tccgccaggt
     3481 cctcccccgg cgcggggttc tgctgccacg tcacgggttg acggccgtcg cgcaaccagg
     3541 acagggtcat ccggtaggtg ctgccgacgt gcctcgccgt ctcgccgagg ttgaggccgg
     3601 ggcaggcggg gacctggcgt tcggggcgct gcccctcggc ggccgaggcg agcgtctcgg
     3661 cctcggccgc gaggacgtcc aggagcctgc cgtagtcgat cagggccttg gtcacgtgcg
     3721 cgcctcgtgc atgatccggt cgaccagggc ggtgaactgg gcggcctggc ggaccaggtc
     3781 gtcggcggag cgggcggtga ccacgcgggt gatgcccgcc tggaccgcgg ccctggtgga
     3841 ggacgcggac gcgaagaacg ccgcccactc cgccagttcc ggcgcgatgc ccgcgagcag
     3901 cacccacacg ctggtgggct tggcgcggcc ccggtgcggg cggccgcgca gggcgagcac
     3961 agcggcgccc gcccgcagcg cggcgaggta ggcgacggcg aaccggtcgg ccgcctggtc
     4021 cgcgcgctcg gcctcggcga taccctcgcg ggcgtgctcg aggagttcga cggccgcggc
     4081 cgggggctgg ggaagcggga cggggaccgg gatcctggtc ctgctgggct tggggaagtc
     4141 gatcgaagct gacatcggcg gcctcctcgc ggcgtcggtg aactcgacga ccaccgcggg
     4201 gagacggcgg ctcctggcgg tggggcgctt cccccgcccc accgccaggg catcactgat
     4261 cgaacatacg ttcgatcgac cgaagcctag cgcctggcgc ggggattcct caacccagga
     4321 cccagcgaca acccgatcgg gatccgtggt ctgattggac gtgtgagcga actggcccat
     4381 ccgggcatgc agaaggtcgc cgcggcactg accgaggcgg gccaccacga ggccgcgcag
     4441 ggcatccggg tgctcgagga tgcggtccgc accgcggcgc aggccgccga agccgtggac
     4501 gtcccggtcg gcgcgatcgc gaacagcctg gtgttcacgg cgatccgcgc ggacgtgccc
     4561 gcaccgctgc tggtgctgac gtcgggcgcg caccgcgccg acaccgacct gctggccgag
     4621 ctcgcgggcg ccgaccgcat cgaacgggcc acaccggact tcgtgcggga gcacacgggt
     4681 caggtcatcg gcggcgtgtc gccgatcggc cacccttcgc ggatcatgac cttcgtggac
     4741 acggacctgg agcagtaccc cgtcgtgtgg gccgcgggcg gacacccgca cgcggtgttc
     4801 cccacgacgt tcgccggact ggtcgagctc accggcggca cacccgcgcg ggtcgcccga
     4861 tgaccgccgc gccgtcgccg cgcaccgagc ggctggtgga actgaccccg caagagctca
     4921 acgcccggct gcacgaagcc ctgcggctgt acgtgacggc gatgaactac ccgccgggga
     4981 cggtcgagca gcgggcaccg atgtggctgg cccacatgct gcgggaggac tggcggtgcg
     5041 tggccgcgct ggacgaccgc gacgagctgg tggggatcgg gtacgggtac cgcggatccg
     5101 tcgggcagtg gtggcacgag caggtgcggc gggggctgac ggcggtcgcg ggggcgcagg
     5161 ccgtggacga gtggatggac gactacttcg agctgacgga actgcatgtg ctgccgcgtg
     5221 cgcaggggag ggggctgggg gaggccctgt tgcgggagct gctgggtggg gtgcccacgt
     5281 cgcacgtgct gttgtcgacg cctgagggac ctagtaatgc ttggcggttg taccggcggg
     5341 tggggttcgt ggatgtgttg aggcattacc agttcacggg ggacccgcgg ccgtttgctg
     5401 tgttggggcg ggaattgccg atgtaggggg atttggtttg tgggtcgctc ctggcgaagc
     5461 ccggcccccg gcgcgcgatt gtctcaatgc ccgatcttcg ttgtcaagac gataaagcca
     5521 tcttgacaac gaagatcggg caggagggcg ctgtggatcg ggggcagagg ggaagtctgg
     5581 cttcgccagc atcggctgcg ccgactcagg catcaggctt cgcctgacca agcatcctcg
     5641 gcttcgccgt cggacggggc atccgcgctt cgcggcggac aggacatccc cgctgcgcgt
     5701 cggacaaggc cccaggcgct tcgcgccgga tgcgcgctgg cgggctgcgc ccaatgtggc
     5761 tggggtgggt gctcgctgtc gttgtacaag taaagggctg cctggggtgg gcagcccttt
     5821 accttgcttg tcttggtgtg cttacagttc tgccaggcgt tcgcggaggg tgtccaggcc
     5881 catggcgccc atttccaggg cttccttgtg gaagcgcttg aggtcgaagg cggagccgtg
     5941 gcgggtgcgg gcgtcgtcgc gggcggctag ccagaggcgt tcgccgatct tgtaggacgg
     6001 ggcctggccg ggccagccga ggtagcggtc gatttcgtcg tggacgtgtg aagggtccgt
     6061 gatggtcctg gtgagcatga actccaggcc gagttcgggg gtccagcgtt cgccctcgtg
     6121 gaagccggtg cccttgggga tctccagctc caagtgcatg ccgatgtcga tgatgacccg
     6181 cgcggcgcgg aacaggtggg cgtcgagcat gcccaggagg ttgccgtcgt cgtcgaggta
     6241 gccgagctcg cgcatcaggc gctcggcgta gagggcccag ccctcgccgt ggccggagac
     6301 ccagcagaac aggcgctgga agtcgttgag cttgtcggag ttgtagacgg cggtggcgac
     6361 ctggaggtgg tggccgggaa cgccctcgtg gtagacggtc gtgagctcgc gccaggtgga
     6421 gaacgtctcg cggtcggcgg gcacggacca ccacatgcgg ccggggcggg agaagtcggg
     6481 ggtggggccg ctgtagtagg cgccgacgcc gccgccgggc ggggcgatgc ggcactcgag
     6541 gcgcatgagc tcgtcgggga gctcgaagtg gacgtcgcgc aggtcgagca gggccttgtc
     6601 ggacagctgc tgcatccacg actggaggcc cgcctggccc tgcacgaggt agcgcgggtc
     6661 ggcgtcgagc gcggcggcgg cctcggcgag cgtggcgccg ggcttgatgc ggccgacgat
     6721 ctgcttcatc tccgactcga tgcgggtgaa ctcctcccaa ccccactcgt aggcctcggc
     6781 gaggtcgagg cgggagccga cgaagtagcg cgacgcgagc cggtaggcct cctcgccgac
     6841 ggcgtccttc accggggcct tggcggcgag gtcgtcgcgc aggaacgcgg ccaggtcgcc
     6901 gtaggcctcg gcggcggccg tcgcgccctt ctccaggtcg gtgcgcaacg cggcgtcgac
     6961 ctgcgttcca cccttctggg caccctcgac caggttcgcg aagaacgaac ggccaccgcg
     7021 gcgaccggac caggtgtcgc actggtcggc gaccttggtg acctggcgca gcgcggagac
     7081 ccgccccttg tccgcggcgt aggacaggcc cgcgcggagc ttggtgacgg cgtccggcat
     7141 cgcggccagg cggcgggcca cgacggccca ctgctcgggg gtgtcggtcg gcatgtggtc
     7201 gaagatctcg cgcagggact gcacggggct cgccagcacg ttcaggtcgc tctcgacccg
     7261 gcccgcctcg tacaggtcga ccgagacgga gccgcgctcc aggaagacgg ccttggcgtc
     7321 gctctccgac ttgtcggcgg gctcggccgc ggagacctcg cggatcgcgc gcacctcgag
     7381 ctcgtgccgc gcggcatgcc cctccggcga gtagtcggtg agctggtcct cgccccccgg
     7441 cagcccgagc tgggtcgccg cgagcgggtc cagcgccacg tagtcgatca cgaaccggtt
     7501 gctgatgtcg tgcacaccag ccgaagagga agccatgccg ggcacgctac ctgccgcctc
     7561 cgacgcggca aaggtcttta ggcttgctca cgattaccag tcgaacggct ggcggacaag
     7621 gtcaacattg ctccctactg gcaggatgac cgcgtgtcca gagcccgtgt gctcctcctg
     7681 ccggtgttcc tgctcctcgc ggcgttctcg ctgacggggt gcgtccgcct gcacgccgcc
     7741 atggcggtct cggaggacga ccgcgtgtcc ggcgagatca tcgccgcgac cccgccgacc
     7801 gcggacaacg accccggccc gcagctgcgc gtgccgtcgg agctggcgag ccgggtcacc
     7861 accaagccct accgggtcga cgcctacgcg ggcacccagc tgttcttcaa cggcctgacc
     7921 ttcgacgagg tccgcaccct ctccgccgcc accagctcct ccagcagccg ctacaccctc
     7981 aacttccgcc gctccggcga cctggtcacg atgtccggct cggtcgacct cacccaggtg
     8041 ccgatcgacc gcgcggacat ccaggtcaag atcagctttc ccggcggcgt ggtcaacacc
     8101 aacggccgcg aggaggacga gggcaccatc gcctggagcc ccaagccggg ccaggcgtcg
     8161 atgctcacgg ccaccgtcca gtacgcgggc gcggactccg agggcttctt cggctgggtg
     8221 atgctcgtcg gcgccctcac cggcggggcg gcgctcatcg tcgtcgtgct ggcgctcgtc
     8281 gcgcaccggc gcagcctggt ggcctgacgc ccggtgcggc accgccgacg tcaccgcaac
     8341 gggtgatcat cggcgggtgg cgcgcaccgg cgcgtcccgg ccgccctagc ggccgcggtg
     8401 ctcccacgcg tgcaccagtg ccgtcgccgc gcggttgccg tactccgaga acggcagcac
     8461 ggtcggccgg gcaccctggt cgcccgcgca cacgaacagc acgcgggtgt tgcggtcgag
     8521 caccagccgg tgggtcatgc cgaagtcggc ctccagcgtg gtcgcggcga gcgcgttcac
     8581 gtcgctgacc gcgatcgcct ggtggacggc gcggacgcgg gcgtcgcgct cggcgccgcg
     8641 ctccttgcgg acgctggact tgtacctgtc gctgagcagg gccgcgtccg gggtgagggt
     8701 ggcccaggac ttggtggcca atcgcaggtc ccagcgcttg ccgaagcggt ccgccgcgac
     8761 gtagcggggc ggtgtcgcca gcaccgacgg gaggtccggc agggaccagc cgtcgtcgtt
     8821 ggcgacgggc accttggcca cgcgcagcag cgcggccatg tcgcggcaga cccgtgagat
     8881 cacgggctcg gccgagcgca ccttggcggc gaagtcgtcg gccagccccc gcttgtgggc
     8941 ctccgaacgg gctcgcttcg cctcggcttc cctcttgaag ttctcgtcga acgtgggcat
     9001 ccgcgcctcc tcacgcacgc gcggggacca ggcccagtcg ggccaccact tccctcgtcg
     9061 ccttcgagcg gttcagggtg tagaagtgca ggcccggcac gccctcggcg agcagccggt
     9121 cccccatctc cgtcaccagg tcgacaccag ccttccggaa gcccttcggg tcgtccacga
     9181 aggggtccag tcgacgggcg accgacgggg gcacgggggc cccggacagc tcgatcgtct
     9241 tggcgagggt gcgcggggtc gtcaacggca tcaggccggg cagcagcgcg gtgtcgcagc
     9301 ccagcgcgtc gacccggtcg cgcagccgca ggaagtcctc cggctggaag aacagctggg
     9361 cgatggcgaa gtccgcgccc gcccgcagct tgcgcaccag gtactccgtg tcggtgtcca
     9421 cgtcgccgga gcgcgggtgg ccgtagggga acgcggcgac gcccacgcag aagtcgccga
     9481 gctcgcggca gagccgcacc agctcctcgg cgtaggtgag gccgtcgggg tgggcgaccc
     9541 actcgccgtt ggggtcgccg ggcgggtcgc cgcgcacggc caggatgttg cgcacgccga
     9601 cggcggcgta ccagccgatg acgttgcgca gctcggcgac ggagtggtcg acggcggtca
     9661 ggtgcgccat cggcaccagg gtggtctcct gcgcgacccg gccggtggtg cggatcgtga
     9721 agtcgcggct ggagcccccg gcgccgtagg tgatggacac gaaggccggg tcgagcggct
     9781 ccagctcgcg gatcgcgcgc cacaggacca gctcgtccgc gctgtcgcgg ggagggaaga
     9841 actcgacgga gaacacggga ccccgcccgt gcaaccgttc gaccaccgtc gtcatgcgcc
     9901 acagcctagt ggggtgcccg ggtgctggga gagggctttc acttgctggg agcaggcccc
     9961 cggtgcggcg gcgacgggcc gcagaggtga cgataggcgg gtgtccgctc cagagctgct
    10021 ccacccgttg gacctcgcgc tgcccacgca cgtcgacgag gcgctggcga cctacctggc
    10081 cgaccggcgc acgctgggcg cgctgatgga cgagaacttc accggggcgg tggacggtct
    10141 cgcggcgttc gtgctgagcg gcggcaagcg catccggccc acgttcgcct ggtggggctg
    10201 gcgggccgcg ggcggtgacc cggaggggcc cctcgcggag tccgtgctca cggcggtcag
    10261 ctcgctggag ctgatccagg cctgcgcgct ggtccacgac gacctgatgg acgcctccga
    10321 ggtgcgccgg ggcaagccga ccgtgcacat cgcgttcgcc caggagcacc gcgaccggcg
    10381 ctggctcggc gagccggagc ggttcgggct cgcggcggcc gtgctgatcg gcgacatcgc
    10441 gttggcctgg gcggacgaca tgctgttcgc cgccggtctg ccgaccgacg cgctgcagcg
    10501 gctgagcctg ccgtggcggg acatgcgcac cgagatgctc gcgggccagt acctcgacgt
    10561 gctcacgcag gcgcgtggcg actcctcgcc cgacgcggcg ctgcggatcg accggctcaa
    10621 gaccgccgcc tacaccgtgg aacggccgct gcacatgggc gcggcgctcg gcggcggctc
    10681 gccggagctg atcgacgggc tgcgccggtt cggcgcggac atcggggtcg cgttccagct
    10741 gcgcgacgac ctgctgggcg tgttcggcga cccggcggtg accggcaagc ccgcgggcga
    10801 cgacctgcgc gagggcaagc ggacgctgct ggtggcgctg ggcatggagt acggcgccga
    10861 cgtgctgcac aaggcgctgg gcaacccgga gctggacgtg gagaccgtcg acgcggtgcg
    10921 cgacgcgctg gtcggcgtcg gcgcggtgga cgcgatcgag gaccggatca ccgagctgac
    10981 gacgtccgcg ctggccgcgc tcgacgcggc gccggtgacg gccccggcgg gcgaccggct
    11041 ggccgagctg gccgtcagcg ccacgaagcg gacctactga ccatgagggt gctgccgggc
    11101 cgcaccgacc acgtcgtggt ggtgggcgcg ggactcgcgg gcctgtccac ggcgctgcac
    11161 ctgctgggca cgggccggtc ggtgacggtc gtcgagcgcg acgccacccc cggcggccgg
    11221 gcggggcggc tggacctgga cggctaccgg atcgacaccg ggccgaccgt gctgaccatg
    11281 ccggagctgg tcgaggacgc gctggccgcg gtcggcgagt cgctggccga ccggctcgac
    11341 ctggtccccg tcgaccccgc ctaccgcgcg cgcttcgccg acggcacgtc gctggacgtg
    11401 cacgccgacg ccgaggagat ggaggcggag gtgcggcgct tcgccggtgc ggacgaggcc
    11461 gcgggctacc gcaggctgcg cacctggctg accgagctgt accgggtgga gaaggactcg
    11521 ttcatcggcg ccaacttcga ctcccccgcc gacctgctgg ggccgtcgct ggcgaagctg
    11581 gccgcgctgc gcgggttcgg caggctcggg ccgtccatcg cccggttcct gcgcgacgag
    11641 cgcctccagc gggtgttctc gttccagtcc ctctacgccg gggtgccgcc gcggcgcgcg
    11701 ctcgccgcgt acgctgtgat cgcctacatg gacaccgtgg cgggtgtgca cttcccgcgc
    11761 ggcggcatgc gggccctgcc cgacgccatg gcgggcgcgg tggccgacgc gggcgccgcc
    11821 ctccggtacc gcacgaccgt ggcctggctg gagcgcatcg gcagccgcgt gacggccgtg
    11881 cgcacgaccc agggcgagcg gatcccgtgc gacgcggtgg tgctgacccc ggacctgccg
    11941 gtggcctacc ggctgctcgg caaggccccg cgccgcccgc gcgcggtgcg ctggtcgccc
    12001 tcggcggtcg tgctgcacgc gggcaccacc cgtacgtggc cggagctggc gcaccacacg
    12061 atcctcttcg gcggggcgtg ggaccggacg ttcgacgaga tcacctcgac cggtcggctg
    12121 atgagcgacc cgtcgctgct ggtcacccag cccacccagg gcgacccgtc gctcgcgccg
    12181 ccggggcggc acctgaactt cgtgctcgcg ccggtgccga acctggaggt cggcccggtc
    12241 gactgggagc gggtcggccc cgcctaccgc gacgagctgc tgcgcaccct ggaggcgcgc
    12301 gggctgaccg ggttcgaggc gtcggtcgag acgtcgcacc tggtcacgcc gcgggactgg
    12361 gcggacatgg ggctcgccgc gggcaccccg ttctcggccg cgcacacgtt cgggcagacc
    12421 ggtccgttcc ggccgcgcaa cctggtcgac ggcgtggaga acgtcgtgct ggcgggctgc
    12481 ggcacgacgc cgggcgtggg cgtgccgccg gtgctgatct ccgggaagct ggccgcgcaa
    12541 cgggtcgcgg gcaccccgct cggggcgctg cgggcgcgga accggacggc gatcgtcacc
    12601 tgatcgtgga gtcccgaacc gcacccggcc gatgtccgaa tactccacat gggcactgcc
    12661 cgcggtgatc ttcacgtgcg aggatcgtca cgggtgttac aagcctgtca cgcgtgcccg
    12721 ccatcgcgtg ccgaggcgcg cgagcgctgt gcaacgatgt tgccgcgatg gcttcgactc
    12781 cgtcccttcc ccgctcgagc gccgcgtccg cgcagcaggc gccgaccgct gatacccgca
    12841 cgccgtcgga accgaccggc atcccgatcc ggaccatcct gctcggggtc gcgggcgtca
    12901 ccctcatctc gctcggcggc gcgggcgcgg gcgcggtcct caagaccgac ccgctgctga
    12961 cggacctgtc gctcagctgg gtccgctacg ggcacggcca cgacctggca acagcgctgc
    13021 tgtacgcggg tctggggctg gtgatctggg cgtgggtgcg gctggggcgg atggtgcacc
    13081 accgcttggt cggcaccgcc gcggtgctga tcgcgatcgt cgcgtggacg ttgccgctgc
    13141 tgctgtcgcc gccgttgttc agcaaggacg tgtacagcta cctggcgcag gggcagctgg
    13201 cgctgcacgg gttcgacccg taccgggtgg gtccggcggc gttgccgtcg ccgttgagcg
    13261 acaacgtgag ctgggtctgg cagaacaccc cggccccgta cggaccgctg ttcatcctga
    13321 tcgccaagac cgtggtgtgg gcgaccggcg ccagtgtcat cggcggcgtg gtcctcatgc
    13381 ggctcgtgct ggccgcgggg ctcgccctga tgtgctggtc gctgccgggg ctgacccgcc
    13441 acctcggtgg acgtccggcg gtcgcgctgt ggctggccgg ggcgaacccg ttgatgctgg
    13501 tccacctgat cggcggcggg cacaacgaca tcctgatggt cggcctgatg gccgcgggcg
    13561 tgctcctcgt gctcgaccgg cgccacgtcc tgggcatcgt cctggtggcc ctcgcggtgg
    13621 cggtgaaggc cacggccgcg gtcgcgctgc cgttcctggt gctggtctgg gccgcccggc
    13681 tggacggctc ccagcgcgcc cggctcgcca aggcgatcgg cggcggggtc gcggtgttcg
    13741 tcgccgtgtt cgccgtgtgc tcgctggtcg cgggcgtgga cctgggctgg atccccgcgc
    13801 tcagctcgtc ctcgacgatc gtgaactggc tgtcgctccc cagcgcggtc ggcgacttcg
    13861 tgtacacgct ggtcagcctg gtcgtgaagg tcgagccggg cgtgttcatg accgtcgccc
    13921 gcggcgccgg gtcgctcctg ctgctctaca tcgcctggcg gcagtggcgg gccgccgagg
    13981 acggcggacc caacgccatc cggcacgccg cgctcaccat gctcgccgtc gccctgctct
    14041 cccccgccac cctgccctgg tacttcagct ggccgctcgt cctcggcgcg ggcctcgcct
    14101 ggaccgcgac cagcctcacc gccgtcgtgt tcttctcgtc ggtgctgctc ctggtcacgt
    14161 tccccaacgg cgacacggcc ctctactcgt ggggctacct ggccctgacc gccgccgtgt
    14221 ccgcgctggc cgccgtgtcc ctcacccgac ccgatcccct ggagctgtcg agcaggtacg
    14281 ggccgcgtcc gtgagcggtc gggaactcga cgccgccggg gtcaccgacc cggccgtgcg
    14341 gctggcctac gcgcgctgcg agcgcgtcaa cgcggcctcc ggcaagacgt tctacctcgc
    14401 caccaagctg ctcgccccgg cgcagcgacc ggccgtgcac gccctgtacg ggttcgcgcg
    14461 gtgggcggac gagatcgtgg actccagctc gtcggcggga cgcggggcgc agctcgacga
    14521 gctcgaacac cagttcgacg accagctgtc cggacggccg gtggaccacc ccgtgctcgc
    14581 cgcgctggcc gacacgatca cccggtaccg gatcgaccgc gggctgttcg ccgacttcct
    14641 cgcgtcgatg cggatggacc tggaggtcga cgagtacgcc gacctggacg ccctcgggcg
    14701 gtacatgcac gggtccgcgg ccgtgatcgg cctgcagctg ctgcccgtcc tgggcacggt
    14761 ggcgccccgc gcggaggccg aggcgggcgc ggcggcgctg ggggtcgcgt tccagctgac
    14821 gaacttcctc cgggacgtcg gcgaggacct cgaccggggg cggctgtacc tgccgctgga
    14881 cgtgctgacg gcgttcggcg tggaccgcga ccggctcctg gcctgccggg acaccggccg
    14941 gtccgacctg cgggtgcggc gcgcgctggc gcacctcgcc gcgcacacct acgccgtcta
    15001 ccgggaggcc gagacggccg tggcgctgct gcggcccgtc tccaggccgt gcgtcaccac
    15061 ggcactgacc ctgtaccggg agatcctgga cggcatcgtg gccgccgact accaggtgtt
    15121 cgcccgacgg gtggtcgtgc cgaggtcgcg gcggctcgcc gtcgcgctac ccggtctggc
    15181 ccgcgccgcg gtggcgcggg ccgtccgtcc gacgtcgggt cagaaggcca acgcctgggc
    15241 ccggcgcttc acctcgcggc cgcggtcacc gcggagcgcc tcgatcggcg atccgggcaa
    15301 cgtctcgtcc tcggtgaaca gccaggtcag gatctcgtcg gtcgagtagc cggagtcgcg
    15361 cagcacggtg atcgtgccga acaacccctt caccactccg cccgccgcga tgaagtcggc
    15421 gggcacgacg aggacaccgg cacgccgttc ggcgagcagc tgcccgtcgc ggagcagctg
    15481 gtggacacgg gtgatgggta ggccaaggcg gtcggcgacc tcggggaggt ccaggacctc
    15541 caggtcgggg gccaatacat ccgcagcggc gggaatcgca ctcacggggg tcacgatgcc
    15601 ataacctctg attcgacgcc ctgcgccaac cgggtcatcc tcgtcctccg tacgatcggt
    15661 agttgtggag aggtctggta cgaaagtgat cggcggattg ctggaacacc gctaccgggt
    15721 ggaccgcgtg ctcgcccgtg gcggcatgtc caccgtgtac cgcggcgtgg acacacgcct
    15781 ggaccgcgcc gtggccatca aggtgatgga cccgcagttc tcggcggacc ggtccttcgt
    15841 agcccgcttc gagcaggagg cccgcgcggc cgcccggctc caccaccccg gcatcgtcgc
    15901 cgtgcacgac cagggagtcg accgaggcga accgggcggc gagcacgtat tcctcatcat
    15961 ggaactcatc gagggcggaa cgctccgcga cctcatcagt gagcgcggca cgctgagcac
    16021 cccgctcgcg ctgagcgtgc tggaacccgt gctgtcggcg ctggccgccg cgcaccaggc
    16081 cgggctcgtg caccgggacg tgaagccgga gaacgtcctg atcggcctgg acggccgggt
    16141 caaggtcgcc gacttcgggc tggtccgcgc cgtggccagc gtgagcacga ccagcgacag
    16201 cacgatactg ggcaccgtgg cctacctctc gccggagcag gtggccaccg gcgcttcgga
    16261 cgcccgaagc gacgtgtact cggcgggcat cgtgctctac gagatgctga ccggcgtcac
    16321 gccctacctc ggcgacacgc ccatctcggt cgcctaccgg cacgtcaacg aggacgtccc
    16381 cgcccccagc accatcgtcc ccggcatccc ggcggagctg gaccagctgg tggtgcgcgc
    16441 gacccgccgc gaccccgcgc agcgcccagc cgacgcggcg gcgttcctgg cggaggccga
    16501 acgggtgcgc gccgcgctgg gcgtgccgag gatggccgtc cccgccccgg cgccgggcca
    16561 gcacgaccag accgtccggg tacgccccgt gcaggcgccg cgcgactcgg ccgccgccga
    16621 gctgacgatg cccgtgctgg ccgccgcggg cgccggtgcg gccacgatca gccaccgggt
    16681 acccggaacg cccggcgggg ccggtggcgg cccccagggc accgtggcgc tcaaccgcac
    16741 cgcctaccag ccgccgcccg ccgctccccc gccgccgaaa ccggccgcga agaagcgggt
    16801 gccgcgcaag accgccgccg aggtctacga ggaggagcgc aagcgcaaca agcgccggtt
    16861 catcctctgg gcgggcctcg tcgccctgct ggccgtcctc gtcggcgtca cggcgtggtg
    16921 gatgggcagc ggccgcttca ccaccgtgcc cggcctcatc ggcgcggagg aggagaccgc
    16981 ggtcgtcctg ctcaaggacg cctcgctcaa gtccaccttc acccaggagg ccagcgacac
    17041 cgtccccaag ggcaaggtgc tgcgcaccga ccccgccgag ggcacggaga agctgcgcgg
    17101 cgacgcggtc aaggtctaca tctcgctcgg caagcccgtc gtcccgatcg tgcgccccgg
    17161 cagcgagagc gcggacgtgg agaacgacat caagaagagc ggcctgaagg cctcgctcga
    17221 cgcgaacgcc gacgtcttca gcgacaccgt caccaagggc aaggtcgtca cctccaagcc
    17281 cgcccccggc accgaggtca agctcaactc gaccgtcacc atcgtgctca gcaagggctc
    17341 cgagccgaaa ccggtcccgg acctcaccgg caagaccaag gacgaggcct tcgccgagct
    17401 cacctccctc ggcttcgaac ccgtcgaggg caagggcgag ccgtccggga acgtcgaggg
    17461 cggcaaggtg gtccgcaccg atccccccgc gaacacgacg atccccgccg ggtcgagcaa
    17521 gaaggtcagc gtgatcctgt ccacggccaa ggcgcaggtc accgtgccga aggtcgaggg
    17581 gcagaaggtg aaggacgcca agaagagcct ggaggacctc ggattgcagg tcgaggtgct
    17641 gttcaaccgg aactcgaact cgaaggtgct caaccagtcg atcccgccga acacgaaggt
    17701 cgacaagggc acgaagatca cgctcatcgc accgtgagga gtggccggtg gaattgactt
    17761 ttggtcaatt ccaccggccg gttcgcacaa taggcgtcac ggggatgtcc gattgccgga
    17821 acggttcccg gacgaggccc agcgcaccgg ggaacgcgtc cggctcggag accgtcgtcg
    17881 acatgcgcga cgaggagcgg tcttgatcca cctggactcg tgcgcgctca tcaagctcgt
    17941 actcgacgag cccgaaagcc gagggcgtca ggtcgtgacg cccggcgcgg gcatctgacc
    18001 cgtgccccga cgtagagcgg cccccgacaa ccgaggttgt cgggggccgc tgtgcggaac
    18061 gggtcaggag cggagcatct cggcgacgag gaaggcgagc tccagggact gctgggtgtt
    18121 gaggcggggg tcgcaggcgg tctcgtagcg gccggccagg tcggcgtcgg agatctcctg
    18181 ggcgccgccc aggcactcgg tgacgtcctc accggtcagc tcgatgtgga tgccgccggg
    18241 gtgggtgccg aggccgcggt ggacctcgaa gaagccctgc acctcgtcga cgatgcggtc
    18301 gaagtgccgc gtcttgtacc cggtggacgc ctcgtgggtg ttgccgtgca tcgggtcgca
    18361 ctgccagatg acctggtgcc cggaggcggt gaccttctcg acgatgccgg ggagcagctc
    18421 gcggaccttg ccgttgccca tgcgggagat gagcgtgagc cgcccggcct cgttgcgcgg
    18481 gtcgaggcgt tcgacgtact cgaccgccat ctcgggcgtg gtcgacgggc cgatcttgag
    18541 gccgatgggg ttggacagca tctcggcgaa cgcgatgtgg gcgccgtcga gctgcctggt
    18601 ccggtcgccg atccacagga agtgggacga caggtcgtag aggcgcggct cgtcgttggt
    18661 ggtgtccaac cgcagcagcg agcgctcgta gtcgagcagc agcgcctcgt gcgaggcgaa
    18721 gatctcggtc gtgtgcaacg acatgtcgtt cacgccgcag gccgacatga agcgcaggcc
    18781 gcggtcgatc tcggcggcca gcgcctcgta gcgctccccg gcgggcgagg tgcgcacgaa
    18841 gtccttgttc cagtcgtgca ggcggtgcag gtcggccatg ccggcgctgg tcatggcgcg
    18901 cagcaggttc atcgccgcgc tcgcgttcgc gtacgccctg accaggcgcg acgggtcggg
    18961 gatccgggct tccggagtcg cgaccagcga gttgacgatg tcgccccggt aggacggcag
    19021 gccgagcgcg tcgatgttcg acgagcgcgg cttggcgtac tgaccggcga tgcggccgac
    19081 cttgaccacg ggcacgctgg cgccgtaggt cagcacgacg gccatctgga gcagcgtccg
    19141 gatgttcgcc ctgatgtgcg gctcggtgtt gtcggcgaag gtctccgcgc agtcgccgcc
    19201 ctggagcagg aaggcgtcgc ctcgggcgac ctcggcgagg ttcgcgcgca gccggtcgat
    19261 ctcggcgggc acggtgatgg ggggaacgct ctcgagcacg gcgcgcaccc gccgcacctg
    19321 ctccgggtca ggccactccg gctgctgggc agccgggcgg gccagcgcgt cgtccaggcg
    19381 agagcgcatc tcgggaggaa gaggcggaag ctcgggaagc gtgtccacgg gcacgtccac
    19441 ggtccagttc acagtgaaca gggtattcgc tcgacctcga gtggcgctct gggggtttcc
    19501 gcagtcggga agccaacgta cggcgtatgc gcggacccgg tccccacctg cattatgaac
    19561 ctatgaattc cacccgattg gatgatggta cggcggcacg gctgctggcg accgctgtgg
    19621 cgaacgtcca acgggaccac cccgtgcact ggacccacat ggtgagctcc gacgcggagc
    19681 tggtgccgca gcggacgttg cacccggtgt tcgccgggtc ctacgactgg cactcgtgcg
    19741 tccaccagac gtggctggcg gtgcgcctgg tccggttgcg gccggacctg gagggctcgg
    19801 ccgaggcggt cgcggtgctg gactcgttgc tgacgccgga gaagtgcgag gtcgaggccg
    19861 agttcttccg cggtccctgg ggcaagcact gggagcgccc gtacggctgg gcgtggctgc
    19921 tcgtgctgga cgccgagctg aagacgtggg gctcggagac cgcgcagcgg tggtccacgg
    19981 cgctggcacc gctcgccgac gtcctgcgcg accggttcct gacgtgggcg agcacggcgc
    20041 ggctgccgat gcgcgtcggc acgcacggca acaccgcgtt cgcaaccagc atggtgctgg
    20101 acgcggcgcg cgccgtggac gacgtggagc tgaccgaggt gtgcgtcgag gcagcgctgc
    20161 ggtggcaccg cgaggacgtg ggctacggcg ggttcgagcc ggacgcggcg gacttcctgt
    20221 cccccgcgct cgtcgagtcc gacctgatgc gccgggtcct ggacgccgac gagttcgccg
    20281 cgtggttcga ggcgttcctg ccgaacttgg acgaggcgcg ctggaaggtg ctgcgcgagc
    20341 cggtcccggt cgacgacccc gccgacccgt acggctcgca cctgtccggg ctggccctgt
    20401 cgcgggcgtg gaactggcag gcggtcgccg aggcgctgcc cgccggccac cgctaccgcg
    20461 acctcgcgct gacctccgcg gaggcgcacc gcgaggcggg ctggcggtac gtgttcggcc
    20521 acggctacgc cgccgagcac tggctcggca cgttcgccgc ctacctggac ctgggcgcct
    20581 actgagacgc gaagagggcc ccgggtcgcc tcggggccct cttcgggaaa cggtgatcag
    20641 ccgaaaaaga cttcggcctc ggccaggcgg tgcgggggca cggtcttgag ctcggcggtc
    20701 gcctcggaga gcttcacccg gacgatctcg gtgccgcgca gggcgaccat cacgccgaag
    20761 tcgccgtcgg cgaccgcgtc ggccgcgtgc aggccgaagc gggtggcgag gacccggtcg
    20821 taggcggtcg ggatgccgcc gcgctgggtg tggcccagca cgaccgcgcg ggactccttg
    20881 ccggtgcgct gcgcgatctc ctccgcgagc cacgtgccga cgccgccgag gcggacgtgg
    20941 ccgaacgcgt ccttctcgcc ggagtgcagg acctcggcgc cgccttcggg cacagcgccc
    21001 tcggccacga cgatgatcgg cgcgtactgc ttctcgaagc gccgctcgac ccagttcacg
    21061 accttctcga cgctgaacgg gcgctcgggc acgaggatga cgttcgcgcc accggcgagg
    21121 ccggagtgca gcgcgatcca gcccgcgtgg cggcccatga cctcgacgac gagggcgcgg
    21181 tggtgcgact cggcggtggt gcgcagccgg tcgatcgact cggtcgcgat gtgcacggcg
    21241 gtgtcgaagc cgaacgtgta gtcggtcgcg ccgaggtcgt tgtcgatggt cttcggcacg
    21301 ccgacgacgc cgatgccgtc gtcggtgagg cgcttcgcga cgccgagggt gtcctcgccg
    21361 ccgatcgcga tcagcgcgtc gacgccctcg tcggagagca ccttgcggat cttgtccacg
    21421 ccgccgtcga ccttgtacgg gttggtccgc gacgagccga ggatggtgcc acccctggtg
    21481 aggatgtcct cgacgtccgc gaggccgacg gacttggtca gtccctcgat cggcccctgc
    21541 cacccgttgc ggaagccgac gatgtcccag ccgtggacct cgacgccctt gcgaacgacg
    21601 gccctgatga ccgcgttcag gccagggcag tccccgccgc cagtgagcac accgatgcgc
    21661 atctgcttcg cccaatctct ctcgaagacc gttgtggtcg agtgccgccc cggctccagc
    21721 gcccggcgtc actacctcgg agcttgaagc gtgtcacgga ctggatcggt gcagcaacac
    21781 cgaggtcaca attctgtgct caggcgaccg ggaacccgcg cttgcggcgc tcctgttcga
    21841 tcaccttcca ccgcgccagg ttgtgcctgg cgtcggcgag cgcgtcgtgc gcgtccgcgg
    21901 gcggctgggg cagccggggc ttgccgacgt cgtcccagcg ctgccgcagg tcgcgggtga
    21961 agcggggcag gctgcgcggc aacgcgggca tcgcacccca gagctgggcc agcgcgacgt
    22021 ggtcgtacgc cgcgaaccag gcccacagct cgacctcgtc gcgggccgct ttcggcccgc
    22081 cgaggaagtc gagcaggtcg cgcttgatct tctcccgact gcgccagcac ttgtcggagg
    22141 gcggcgggag ctggttgagc acgttgttgc gcacccaggg accggccttc gccgggtcga
    22201 actcggtcga gacggcgtag aactcgtcgc cctgctcggt caccacaccg atcgagatca
    22261 ggtcgatggt ggtgccgtcc tcgatgaatt cgcagtcgta gaagaaacgc accgggccca
    22321 ccctaagtgc ccgctcagcc cgccttcgtc tcgggcacgc gatcgacgga cttggcatcc
    22381 ggccggccgg gcacctccac ggcggcctcc gccgcggcct ggtcctcctt ggccttggcc
    22441 gcgtagacgt ccacgtactc ctggccggtc agctccatca gggcgtacat gatctcgtcg
    22501 gtgatcgacc gcagcacgaa ccggtcgccg gagagccctt cgtagcggga gaagtccagc
    22561 ggcttgccga tcttgatcga gatctgggtc ggcttccaca ttcgggagcc gatcgggttc
    22621 gccttgtcgg tgccgaacat cgcgaccggg atcaccggca cgcccgcttc cagcgcgatc
    22681 caggccaccc cgaccttgcc cttgtacagg cggccgtccg gcgagcgcgt gccctccggg
    22741 tagatgccca gcagcttgcc ctcccgcagg atccgcacgc cggtggacag cgcgccctgc
    22801 gccgccgagg cgctcgaccg gtcgatcggc acctgcccga ccccggacat gaacgccttc
    22861 tgcaaccagc ccttcacgcc ggtacccgtg aagtactcga tcttggccgg gaacgtcacc
    22921 ctccgcgaca gcttcagcgg caggaagaag gagtcggaca ccgccaggtg gttgctcgcc
    22981 aggatggcgc caccttcctt cgggatgttc tcggcgccct cgatgatccg ggggcggaag
    23041 aacaccttca gcaggggtcc gagaaaaatg tgcttcatca accagtacag cactgctggg
    23101 agcgcctccc tcaccgacct tgatccgacc tcagcctacg tagccgacgg cacaaggcac
    23161 aacgaacacg cgcacccggt cgatacgggc ccagatccct ccggttgccg ggacccggaa
    23221 cgcggggcgg acgtgggacg atgtcaggga agtggacgac gcccggacac gggagggctg
    23281 gagcacgccg atggattccc gacgcgactc gaccgacggc cccgaggacg tggacgccgc
    23341 cttcgccgaa atcgtcgcca gcctcgaacg ggacggtatg ggcgccaact ggcccgaccc
    23401 tcccgacttc gacgaccccc aggacgaacc cgtggccgcc ggcatccgcc ccgaaggcca
    23461 accccgcgtc cccacccccg acccggacgc ggacgacgag gacgacaacg agcacttcgt
    23521 ccccccagaa cccccaccac tgccgaagct gcgcgccggc accatcgccg ccctagccgt
    23581 catcctcgtc ggcgtagcac tgctcttcat ccctcaactc ttcggcatct ccacccaact
    23641 aaccgtccca gccgccctgg tcgtcctctg cgccggcgtc ggctggctag tcctcagaat
    23701 ccgccccgac ccaccccagg actccggctg ggacgacggc gcagtcctct aacaacagca
    23761 aaaacaacaa acaaagccac caccaccaac ttgcccctcg cggagcgagg aacaccgacc
    23821 cgacgcagcc gccacctcgc atccggcgcg gagcgcccgc cgcttcgtcc gacggcgaag
    23881 ccgaggatgc cttgtcgggc ggagcccgat gccctgtcgg acgtagtccg atgccctgtc
    23941 gggcggagcc cgatgctggc gaagccagac ctacccctgc ccccgataca cagcgccctc
    24001 ctgccctgcc ctgctttgtc aagacagctt tatcgtcttg acaaagcagg gcagggcatt
    24061 gagacaatcg cgcgccgggg gccgggcttc accaggggtg ggcaccacga aaccgacggc
    24121 caggctccgc cgggaaacga cggtcaaacc tcaccgaagg acggacggaa agcaccacca
    24181 aggcctcgcc tggggacggg aacaccccac accaaccccc gcccccctac ctccgcccgt
    24241 tcctagccgc ccgatccccc agctcccgag ccaacgtagc cacccccacc aaccccgcgt
    24301 cgtcccccag ctgcgccgtc cggatcctcg ccaacggccg gtgccccgcc cccgtcacca
    24361 ccgccgcgta cctctcccgc gcctcgtcca ggaacagcgg cgccgactcc gacacccctc
    24421 ccccgatcac caccatctcc gggtcgtaca cgtccgcgac cagcgccaac ccgtctccga
    24481 gccatttcgc caggtcggac atggcgcgca gggccaacgg gtccccgtcc cgcgcggccg
    24541 ccgccacccg ccgcccggtg accgcccgcg agtccttcag cgcttcccgc accagcaccg
    24601 tcgacgcacc ggggttcttc gccagcagtt ccacggcggt cgtgctcagc gccgtcccgc
    24661 tgcagtacct ctcccaacac ccgttcttcc cgcaggggca cggccgcccg tccggcacca
    24721 gcctcaggtg cccgagctcg ggcgcgaccc cgtaggcgcc ccggtacacc tgcccgtcga
    24781 tcagcagcgc cccgccgatc ccggtcccca gcgccaccag gacggcgagc ttcgccccgc
    24841 gcgcggcgcc gaaccggtgc tcggccagcg cggcggcgtt cgcgtcgtgc tccagcacga
    24901 ccggcatccc gatgcgttcc gacagccgct gcgccaccgg cgcctgccgc cacgcgaggt
    24961 gcggtgcgaa ccgcaccgtc cgccggtcgg tggccacgaa acccgcgacg gcgagtccca
    25021 cggccgagat gtcgtgccgg gtggccagct ccgacaccgc ggacgtgatc gcgtcctcca
    25081 gcggtccctc g
//
