LOCUS       NZ_PVTF01000013        10375 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Umezawaea tangerina strain DSM 44720 Ga0180964_113, whole genome
            shotgun sequence.
ACCESSION   NZ_PVTF01000013
VERSION     NZ_PVTF01000013.1
KEYWORDS    WGS; RefSeq.
SOURCE      Umezawaea tangerina
  ORGANISM  Umezawaea tangerina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Umezawaea.
REFERENCE   1  (bases 1 to 322310)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 322310)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Expected Final Version            :: No
            Genome Coverage                   :: 86.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003002815.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:47:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,483
            CDSs (total)                      :: 9,418
            Genes (coding)                    :: 9,322
            CDSs (with protein)               :: 9,322
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 20 of 97
            Pseudo Genes (incomplete)         :: 83 of 97
            Pseudo Genes (internal stop)      :: 2 of 97
            Pseudo Genes (multiple problems)  :: 8 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:41:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 212076
            Orig. end                         :: 222451
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVTF01000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10375
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="2"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10375
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10375
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5375](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5375)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            complement(1033..1815)
                     /locus_tag="CLV43_RS36555"
                     /old_locus_tag="CLV43_113188"
     CDS             complement(1033..1815)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF036686.4"
                     /locus_tag="CLV43_RS36555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_113188"
                     /product="hypothetical protein"
                     /protein_id="WP_106193330.1"
                     /transl_table=11
                     /translation="MNRDTWVAQLGILVIHNDPVVEAELWAMAPPGVTVHTARFESPTS
                     TGAEYTGESWRRMVDAPDVRRGLVQLGQMDLSAICLCFGSASFFGGLEFDEGFVAAAVG
                     LTGGTPVYTAAQAIRSALAATGVGRPLVVLPPWFTRPTFTATEDYLTSAGFDVAGLTQF
                     QLDSRWADVQRHQLFDRGGRWEVHPDEVCRQVAAGFPADADGILIPGSGFRSWEAIEQL
                     ERRLGVPVVTSNQACLWHLLDLAGVEATVRGGGRLLNT"
     gene            complement(1812..3203)
                     /locus_tag="CLV43_RS36560"
                     /old_locus_tag="CLV43_113189"
     CDS             complement(1812..3203)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="CLV43_RS36560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_113189"
                     /product="MFS transporter"
                     /protein_id="WP_211304719.1"
                     /transl_table=11
                     /translation="MRPRSANAALAILAVAQFLIALDYSIVYIALPSIGDELGLTESSV
                     QWVVSGYAVFFAGFLVVGGRASDRFGPRTLFIVGMLLFGIASLAGGLAPGTPVLMVARA
                     AQGIAAAILQPAVIALINTSFAAGPLRNKALSVWGTVGASGLAAGVMIGGLLTTVSWRW
                     VFLINLPLAVVCALAAPKLLPRLDETIRKHTSLNVPSAVLCTATVLSTALALTQASSRG
                     WTDASTLAGFGVAAALLVAFVWQERRSAHPLVDPLLRRTRSLLVGCGATAFYMGSVGNQ
                     FFVVTLLVQQLRGYGPIAAGLAFLPMAVAIAVANSVSARIVAKLGVRLTLTLAFVADAV
                     GLLLLAFQTSGDSYVLDLLPGLLITGFSHGVTYVAMFIAGTADVEDRNQGVAGAMMTTA
                     QYMSGALGVAVLVLVLGPNPGQTSFGWAFVTTATAATFGAALAWFGLARRSAAAAVPEA
                     SGSRS"
     misc_feature    3228..3243
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.67"
                     /tool="antismash"
     gene            complement(3264..3950)
                     /locus_tag="CLV43_RS36565"
                     /old_locus_tag="CLV43_113190"
     CDS             complement(3264..3950)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024811.4"
                     /locus_tag="CLV43_RS36565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_113190"
                     /product="HAD family hydrolase"
                     /protein_id="WP_106193333.1"
                     /sec_met_domain="HAD_2 (E-value: 1.7e-28, bitscore: 94.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADDRAVLFDVDGTLVDTPGGMLGVLRAVLEESGHAVADDLVRR
                     TIGRPLAASFAGLLFLPEDHPDVAHAVTRARALFTETVIPSAADLVFPGIPELLAELRA
                     QGRPLAVVTSKVRPSAVELLGAAGLLDAFDTLSCHGMADRGKPHADLALLAAGALGVPP
                     RRCVVVGDAVDDVRMASAAGMDACGVDFGVATRAELVAAGASRVVGSVAELHDAVAPRR
                     LHTSDR"
     gene            complement(3947..4894)
                     /locus_tag="CLV43_RS36570"
                     /old_locus_tag="CLV43_113191"
     CDS             complement(3947..4894)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683703.1"
                     /locus_tag="CLV43_RS36570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_113191"
                     /product="pseudouridine-5'-phosphate glycosidase"
                     /protein_id="WP_106193335.1"
                     /transl_table=11
                     /translation="MSARDRTELFSISEEVSDALASGHPVVALESSGVVQGLKYPLNLE
                     TALDIDKTIRANGAVPARTGVVDSRFVVGMSEAQVELFATTPSVPKISTRDIGSALASG
                     GHGGTTVSAALVAADHVGIDVFAVAGIGGVHFDAQRSFDISADLIEFTRHRIAVVCAGA
                     KSLLDPALTLEYLETQGVPVVGYRCDDFPAYYSTSSGQPNPRRVDDLDVLASAIRLHWQ
                     VGNGGGFLVTHPIAEQDALPSAEMYELIHQKQAEAERAGVSGPSLTPHILKAVSAATQG
                     RTGAANRSVLLSTSAVAAELAVAMHKRSALVGVS"
     gene            complement(5001..5375)
                     /locus_tag="CLV43_RS36575"
                     /old_locus_tag="CLV43_113192"
     CDS             complement(5001..5375)
                     /GO_function="GO:0033990 - ectoine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645375.1"
                     /locus_tag="CLV43_RS36575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_113192"
                     /product="ectoine synthase"
                     /protein_id="WP_106193337.1"
                     /sec_met_domain="ectoine_synt (E-value: 2.3e-30, bitscore:
                     99.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVREKSEVNCVDWGNGLSFRFLVETDGMGFTVAHTVVKAGSKSP
                     LHYRRHLEACYCISGSGQVIAADGTVHEIEPGVMYALDNHDEHFLIAAPEGDMELISVF
                     NPPLQGDERHNFDSDEFSHY"
     gene            complement(5416..5667)
                     /locus_tag="CLV43_RS36580"
                     /old_locus_tag="CLV43_113193"
     CDS             complement(5416..5667)
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680900.1"
                     /locus_tag="CLV43_RS36580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_113193"
                     /product="acyl carrier protein"
                     /protein_id="WP_106193338.1"
                     /sec_met_domain="PP-binding (E-value: 9.7e-06, bitscore:
                     20.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIEVEIKQYVVSSFAPDVPPDQLPSDLDLLDNGVVDSLGLLRLI
                     AWVGDKYDIPVDEMNISPLQFSSVDSIQGFIRETRSFV"
     misc_feature    5757..5771
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.46"
                     /tool="antismash"
     gene            complement(5985..6164)
                     /locus_tag="CLV43_RS36585"
                     /old_locus_tag="CLV43_113194"
     CDS             complement(5985..6164)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672325.1"
                     /locus_tag="CLV43_RS36585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_113194"
                     /product="hypothetical protein"
                     /protein_id="WP_106193340.1"
                     /transl_table=11
                     /translation="MSAGPRRRTVPTDLAALAAGVSEATIRKWASRGKLTRHGRPGRAE
                     YDLDEVCDLVNGRA"
     gene            complement(6161..6772)
                     /locus_tag="CLV43_RS36590"
                     /old_locus_tag="CLV43_113195"
     CDS             complement(6161..6772)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV43_RS36590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV43_113195"
                     /product="OvmZ protein"
                     /protein_id="WP_146175037.1"
                     /transl_table=11
                     /translation="MTKSLCRAPSCARQVSGPGPRVCSGCRDAVAGDLALLADLHEACA
                     EALTPGRRPMAERVGGHRPAGIALDDTAVSVRSDVLDALVSWAGMVAAERGTPGPGGRS
                     VPRLVGFLTGQLDWLLGHDAAADFVTEVADLVAAAKAVLEPDPVRRKELGPCGEPGCPH
                     VVLATLRTGRAAEVACAAGHTWSPGRWLLLSRRAAAGSAA"
     gene            complement(6769..7725)
                     /locus_tag="CLV43_RS36595"
                     /old_locus_tag="CLV43_113196"
     CDS             complement(6769..7725)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014476.4"
                     /locus_tag="CLV43_RS36595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_113196"
                     /product="hypothetical protein"
                     /protein_id="WP_106193343.1"
                     /transl_table=11
                     /translation="MDGPMLRLSADDLCTAIAGVDPVPVLAAELMAARGDAGAVSGVRW
                     GEARGEFAVLEDTATGERCALPAVALRAYRAAALTALAARQLLAPGVVTASVIGSGLAA
                     QLQLMVIARHVPDVSHVAVCALTGDRGLPVSTRVVDQLDHAGIGLAVTTHVDEAVFGAN
                     LVAVTGFDADVMRIDHLAKGAVLVNATGNDLPEHLVDGANQVYVDDPALLDSAGHRHFA
                     RRRPSTEDTVCGARRHDGARRERGIESDLGTVLTGAHPGRTRLDHVLLVELLGTTALDL
                     ALASLVHRAALVLGLGGFVTEGPAAPPSTTTATRSES"
     misc_feature    complement(7741..7757)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    7851..7869
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.72"
                     /tool="antismash"
     misc_feature    complement(7907..7920)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.35"
                     /tool="antismash"
     gene            7914..8114
                     /locus_tag="CLV43_RS36600"
                     /old_locus_tag="CLV43_113197"
     CDS             7914..8114
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV43_RS36600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV43_113197"
                     /product="hypothetical protein"
                     /protein_id="WP_106193345.1"
                     /transl_table=11
                     /translation="MFVSRKLAAPALVSLLSGTALLAAIASGQATTVSAEDTHWGTVTS
                     DCPADTHWSTDLNACVPNVER"
     misc_feature    complement(8326..8339)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.31"
                     /tool="antismash"
     gene            8676..9502
                     /locus_tag="CLV43_RS36605"
     CDS             join(8676..9036,9036..9502)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011879774.1"
                     /locus_tag="CLV43_RS36605"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5 family transposase"
                     /protein_id="WP_211304720.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MRKGQRPPWIVSDELWARIEPLLPVVPHDPRHPGRPRLDDRKVLC
                     GILFVLYTGIQWEFLPRELGFGSGMTAWRRLRDWSAAGVWERLHETLLAELHAAGALDW
                     SRAVIDSSHVRAMKGGPKTGPSPVDRARTGSKHHLITEAHGIPLQFSLTGGNRNDVTQL
                     MPLIQTIPPVRGRRGRPRRRPDTLYADRGYDHDKYRTQVRHLGITPFIARRGEEHGSGL
                     GVYRWVVEQSIALLHWFRRLRVRWEIRDDIHEAFLRLACAIICFRRLASLGLC"
     misc_feature    8700..8713
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
ORIGIN
        1 cggactcgtc gacgacgagc gcgtcgacgc cgtcgatcgg cgtgccgatc gggacgactc
       61 cgtgccgggc gacctcggag ggcacgacct cgtgcaggaa gctgtcgttg gtctcggtgc
      121 acccgtagac gttccacatc cgggcgtccg ggaacgcggc ggcgacccgg tcgagcaggc
      181 tcggcggcat cgcgtccccg gtgaagatca ggtgccggac ccctgggaac acccggccgg
      241 tggcggcctc gaccacgagc cggaagaaca tcggcacggc ctgcaccacg gcgggtgcgc
      301 gttcggcgca cagctgcgcc aggtgggcgc cgtcgaccgc gcgctccggg tcgacgagct
      361 cgacgcaggc gcccacggac agggcggccc acacgtcgag caggcacagg tcgaagttca
      421 acggcgcgta gttgagcacc cgcgtccccg gcccgatgtc gaacctgccg gtggcccagg
      481 acaggaagct gtccacgccc tcggaggcga ggaccaccat cttcggcgtc ccggtcgacc
      541 cggaggtggt cagcaccagc cccggttcgg ccgggtaccg ggtgcgcccg ccgaggccgg
      601 tgcgccgggc cgaggcgggc tcgtcctcgg tcgcgctcag cacgtgggtg cagccgagct
      661 gcgcgcacag gtcggccagt gccgcctcgc cgagcccggt ggagggcagg aggacctgcc
      721 tcccggtgcg gacgcaggcg atgaccaggg cgatcgtgta gggcgacttg cgggccggga
      781 cgcagaccgg cacgccgtcg ccgatcccga gcgagacgag cgactcgtgg gcggactcga
      841 ccatgtccgc gagcccggcg tagtcgacga cgcggtcgcc ccaggacagg gctggcgcgt
      901 ccggccgcgt ccgcgccatc tcggcgaacg cggtcacgaa ggagctggac ggcatcggat
      961 tcccttctgt cggcacggcg aaggcccgcg ctcggggggt gagcacgggc cttcggggtg
     1021 gcgttgacgc ggtcaggtgt tcagcaggcg gccgccaccc cggacggtgg cctcgacgcc
     1081 cgcgaggtcg agcaggtgcc acaggcaggc ctggttcgac gtcaccacgg gcacgccgag
     1141 ccgccgttcg agctgctcga tcgcctccca ggagcggaac ccgctgccgg ggatgaggat
     1201 cccgtccgcg tcggccggga acccggcggc gacctggcgg cacacctcgt ccgggtgcac
     1261 ctcccagcgg ccgccgcggt cgaacagctg gtgccgctgg acgtccgccc agcgggagtc
     1321 gagctggaac tgcgtcagcc cggcgacgtc gaacccggcc gaggtgaggt agtcctcggt
     1381 ggcggtgaag gtcggcctgg tgaaccacgg gggcagcacg acgagcgggc ggcccacccc
     1441 ggtcgcggcc agcgccgagc ggatcgcctg cgccgccgtg tacacggggg tgccgccggt
     1501 cagcccgacc gcggcggcca cgaacccctc gtcgaactcc agcccgccga agaagctggc
     1561 cgagccgaag cacaggcaga tcgcggacag gtccatctgc cccagctgca ccagcccccg
     1621 ccggacgtcc ggcgcgtcga ccatccgccg ccacgactcg ccggtgtact cggcgcccgt
     1681 gctggtgggg ctctcgaacc gggcggtgtg gacggtgacg ccggggggcg ccatggccca
     1741 cagctccgcc tcgaccacgg ggtcgttgtg gatgaccagg atcccgagct gcgcgaccca
     1801 ggtgtcccgg ttcacgaccg cgaccccgat gcctccggga ccgccgcggc ggccgaccgg
     1861 cgggccaggc cgaaccaggc cagcgccgcg ccgaacgtcg ccgcggtggc ggtcgtgacg
     1921 aaggcccagc cgaagctcgt ctggccgggg ttcggaccca gcaccaggac caggacggcc
     1981 acgccgagcg cgccgctcat gtactgcgcc gtggtcatca tggccccggc gacgccctgg
     2041 ttgcggtcct cgacgtcggc ggtaccggcg atgaacatcg ccacgtaggt gacgccgtgg
     2101 ctgaagccgg tgatcagcag gccgggcagc aggtcgagca cgtagctgtc cccggaggtc
     2161 tggaacgcga gcagcagcag ccccaccgcg tcggcgacga acgccagggt gagggtcagc
     2221 cgcacgccca gcttggcgac gatccgggcc gacaccgagt tcgccaccgc gatggcgacg
     2281 gccatcggca ggaacgcgag ccccgccgcg atcgggccgt acccgcgcag ctgctggacc
     2341 agcagcgtga cgacgaagaa ctggttgccg acgctgccca tgtagaacgc cgtggcgccg
     2401 cagcccacca gcagcgaccg ggtgcgccgc agcagcgggt cgaccagcgg gtgggcgctt
     2461 cggcgctcct gccagacgaa cgcgaccagc agtgccgcgg ccacgccgaa cccggcgagc
     2521 gtgctggcgt ccgtccagcc ccggctcgac gcctgggtca gcgcgagggc cgtggacagc
     2581 acggtggcgg tgcacaggac ggcgctgggg acgttgagcg aggtgtgctt gcggatcgtc
     2641 tcgtcgagcc tgggcagcag cttcggcgcg gccagcgcgc agaccaccgc gagcggcagg
     2701 ttgatcagga acacccagcg ccacgagacc gtggtgagca gaccgccgat catgacaccc
     2761 gcggccaggc cggacgcgcc gaccgtgccc cacaccgaca gcgccttgtt gcgcagcggt
     2821 cccgcggcga acgaggtgtt gatcagggcg atgaccgcgg gttgcaggat cgccgccgcg
     2881 atgccctgcg cggcgcgggc caccatgagc accggcgtgc cgggggcgag cccgcccgcc
     2941 agcgaggcga tgccgaacag cagcatgccg acgatgaaga gcgtccgcgg cccgaagcgg
     3001 tccgaggccc gtccgccgac gacgaggaag cccgcgaaga acacggcgta accgctgacg
     3061 acccactgga ccgagctctc ggtcagcccg agctcgtcgc cgatgctcgg cagcgcgatg
     3121 tagacgatgg agtagtcgag cgcgatgagg aactgggcga cggcgaggat cgccagcgcg
     3181 gcgttcgccg agcggggtcg cacagcggga acggtgcccg gtagggccat gggaatcacc
     3241 ctcgtgtgag ctggtgttcg gagttacctg tcggaggtgt gcagccgccg cggggcgacg
     3301 gcgtcgtgga gctcggccac gctgcccacg accctcgacg ccccggcggc cacgagctcc
     3361 gcccgtgtcg ccacgccgaa gtcgacgccg caggcgtcca tcccggcggc cgaggccatg
     3421 cggacgtcgt cgaccgcgtc gccgacgacg acgcaccgcc gcggcggcac gccgagcgcg
     3481 cccgcggcga gcagggcgag gtcggcgtgg ggcttgccgc ggtcggccat gccgtggcac
     3541 gacagcgtgt cgaaggcgtc gagcagaccg gccgcgccca gcagctccac ggcgctgggc
     3601 cggaccttgc tggtgacgac cgccagcggc ctgccctgcg cccgcagctc cgccaggagc
     3661 tcggggatgc cggggaagac gaggtcggcg gccgacggga tcaccgtctc ggtgaacagc
     3721 gcgcgggcgc gggtcacggc gtgcgccacg tccgggtggt cctcggggag gaagagcagg
     3781 cccgcgaacg aggcggccag cggccgtccg atcgtccggc gcaccaggtc gtcggccacc
     3841 gcgtgacccg actcctcgag caccgcgcgc agcacgccga gcatgccgcc gggggtgtcc
     3901 acgagggtgc cgtccacgtc gaagaggacc gcgcggtcgt cggcgctcac gagacgccga
     3961 ccagtgccga ccgcttgtgc atggcgacgg ccagctcggc ggcgaccgcg ctggtggaca
     4021 gcagcaccga ccggttggcc gcgccggtcc ggccctgcgt ggccgccgag acggccttga
     4081 ggatgtgcgg cgtcagcgac ggtccgctga ccccggcgcg ctccgcctcg gcctgcttct
     4141 ggtggatcag ctcgtacatc tcggccgacg gcagcgcgtc ctgctcggcg atcgggtgcg
     4201 tgaccaggaa cccgccgccg ttgccgacct gccagtgcag ccggatcgcg gaggcgagca
     4261 cgtcgaggtc gtcgacccgg cgcgggttgg gctgcccgct ggaggtgctg tagtaggcgg
     4321 ggaagtcgtc gcagcggtac ccgacgaccg ggacgccctg ggtctccagg tactccagcg
     4381 tcagcgcggg gtcgagcagc gacttggccc cggcgcagac gaccgcgatc cggtgccggg
     4441 tgaactcgat gaggtcggcg gagatgtcga agctgcgctg ggcgtcgaag tgcacgccgc
     4501 cgatgcccgc gaccgcgaac acgtcgatgc cgacgtggtc ggccgccacc agcgccgccg
     4561 agacggtggt gccgccgtgg ccgccggagg cgagcgcgga cccgatgtcg cgggtgctga
     4621 tcttgggcac gctgggggtc gtcgcgaaca gctccacctg cgcttcggac atgccgacga
     4681 cgaaccggct gtccaccaca ccggtgcggg cgggcacggc gccgttcgcg cggatggtct
     4741 tgtcgatgtc gagagccgtc tccaggttca gggggtactt caggccctgc accacacccg
     4801 acgactccag tgccacgacg gggtggccgg acgccagggc gtcggagacc tcctcggaga
     4861 tcgagaacag ctcggttcgg tcgcgtgcgg acatcggtcg ctcctccttg tgactggact
     4921 ggctggtcgc cttcgcccgc gtggacgggg gcctggccgc cggccggggt gcgcgggccg
     4981 caccccggcc ggcgaccggg ctagtagtgg gagaactcgt cggagtcgaa gttgtgccgc
     5041 tcatcgccct gcaacggcgg gttgaacacg ctgatgagct ccatgtcgcc ctcgggggcg
     5101 gcgatcagga agtgctcgtc gtggttgtcc agcgcgtaca tgacgccggg ctcgatctcg
     5161 tggaccgtgc cgtcggcggc gatcacctgg ccgctgccgg agatgcagta gcaggcctcg
     5221 aggtgcctgc ggtagtgcag cggcgacttg gaaccggcct tcaccaccgt gtgcgccacg
     5281 gtgaacccca ttccgtcggt ttccacgagg aaacggaagc tgagcccgtt gccccagtcg
     5341 acgcagttga cctcggactt ctcgcgaacg atcatcgctt gcacctttcc cgtcgtaagt
     5401 gggggtcgaa cagggtcaga cgaaactgcg cgtctcccgg atgaacccct ggatggagtc
     5461 caccgagctg aactggagcg gggagatgtt catctcgtcc accgggatgt cgtacttgtc
     5521 gccgacccac gcgatgagcc gcagcagacc gaggctgtcg accacgccgt tgtccagcag
     5581 gtccaggtcg gagggcagct ggtcgggcgg cacgtcgggg gcgaagctgg acaccacgta
     5641 ctgcttgatc tcgacttcga tcgtcacggg atttcctctc gtggttacag gaggacgtcg
     5701 ttccggccgc gaacacgaca atgggcccca gatcgcacgg tcggacacgt gcgacgattt
     5761 cgcaggaaat cccggaacga tcgggagggg gtaattcgat gtgggcacag cggtgccgtg
     5821 ctcaaagcgt gacagccgac cgcgcctcac gtcaatcctt ttccatggag tttttcggac
     5881 gtcttccgac gcctttttcc gggcatgcga atgaggccct cattcgcaca agggcctcat
     5941 tgattcgcaa aagacgccaa gtaatcggta acgctggcgg tgggtcaggc gcgcccgttc
     6001 accaggtcgc acacctcgtc gaggtcgtac tcggcccttc cgggtctgcc gtggcgggtg
     6061 agcttgccgc ggctggccca cttgcggatg gtcgcctccg agacacccgc ggcgagcgcg
     6121 gccaggtcgg tgggcaccgt gcgccgcctc ggcccggcgc tcacgccgcg ctcccggcgg
     6181 ccgcgcgcct gctcagcagc agccagcggc ccggcgacca ggtgtgcccg gcggcgcagg
     6241 ccacctcggc cgcccggccc gtgcgcagcg tcgcgagcac gacgtgcggg catccgggct
     6301 caccacacgg cccgagttcc ttgcgccgca cgggatcggg ctccagcacc gccttggcgg
     6361 cggcgaccag gtccgcgacc tcggtgacga agtccgccgc cgcgtcgtgc ccgagcagcc
     6421 agtccagctg cccggtcagg aaccccacca gccgcggcac cgaacgcccg ccgggtccgg
     6481 gtgtcccgcg ctcggcggcc accatccccg cccacgagac cagcgcgtcg agcacgtcgg
     6541 accgcaccga caccgcggtg tcgtccagcg cgatcccggc gggccggtgc ccgccgaccc
     6601 gctcggccat cggccgcctg ccgggcgtca acgcctccgc gcacgcctcg tgcaggtcgg
     6661 ccaggagcgc caggtcgcct gcgacggcgt cccggcaccc ggagcacacc cgcggacccg
     6721 gtccgctcac ctgccgtgcg caggaaggcg cccggcacaa cgacttcgtc atgactcact
     6781 cctcgtggcg gtggtcgtgg acgggggagc ggcgggcccc tcggtgacga acccgccgag
     6841 gccgagcacc agcgcggccc ggtgcaccag gctcgccaga gccaggtcca gcgcggtcgt
     6901 gccgagcagt tcgaccagca gcacgtggtc gagccgggtg cggccggggt gcgcgccggt
     6961 gaggacggtg ccgaggtcgg actcgatccc gcgctcccgc cgcgccccgt cgtgcctgcg
     7021 cgccccgcac accgtgtcct ccgtggacgg acgccgccgc gcgaagtggc ggtgtccggc
     7081 ggagtccagc agggcggggt cgtccacgta gacctggttc gccccgtcca ccaggtgctc
     7141 cgggaggtcg ttgccggtcg cgttgaccag caccgccccc ttggccaggt ggtcgatgcg
     7201 catgacgtcg gcgtcgaacc cggtgaccgc caccaggttc gcgccgaaca cggcctcgtc
     7261 gacgtgggtc gtcacggcca gcccgatgcc cgcgtggtcg agctggtcga ccacccgagt
     7321 cgacaccggg agaccgcggt cgccggtcag cgcgcacacc gcgacgtggc tgacgtccgg
     7381 cacgtgccgc gcgatcacca tcagctgcag ctgcgcggcc agacccgagc cgatcaccga
     7441 cgcggtcacc acccccggcg cgagcagctg ccgggccgcg agcgccgtca acgccgccgc
     7501 ccggtaggcc ctcagggcca ccgcgggcaa cgcgcaccgc tcgccggtgg ccgtgtcctc
     7561 cagcaccgcg aactccccgc gcgcctcacc ccaccgcaca cccgacaccg cgcccgcgtc
     7621 cccgcgcgcc gccatcagct ccgcggcgag caccggcacc gggtcgaccc cggcgatggc
     7681 cgtgcacaga tcgtccgcac tcaaccggag catcgggccg tccatcccgg acctcctccc
     7741 atgttcgcgt gtatcacctg cgaacactgt gcggccgccc cttgtcgacc ctctttcgat
     7801 cggctatcgg ccgaccgaag gcgcaccgac agcgcgcgga aggccgaccg atggcgaccc
     7861 cctgtcaact gatcccagac caggagcagc cagcagaaac accggaggaa accatgttcg
     7921 tcagccgcaa gctcgccgcc cccgccctcg tctccctcct ctccggcacc gccctcctcg
     7981 cggcgatcgc ctcgggccag gcgacgacgg tcagcgccga ggacacgcac tgggggaccg
     8041 tgacgtccga ctgccccgcc gacacccact ggagcaccga cctcaacgcc tgcgtcccga
     8101 acgtcgaacg ctgacaacag atcaaacaag gcaaggcaac aaggcacgca ataccgctca
     8161 agcacgacaa cacagcaacg aacacacagc aatgaacaca ctggggccaa caaccacagc
     8221 accgagcgaa cctgcctgat caccacaacg gcagtgacca cccccgctca ccacgctgga
     8281 agtgagcagt acccgtccgc cgtgcggccg gcttgacttg gggtttttgg gcttaaaatt
     8341 ggtcggcggg caggctctac cacctgccct ttttcgcccg acgaagccca aaaaaggggc
     8401 cccaagtcaa gccggccgca cccggagtcc gcggcagcga caccgggcgg gacacacggc
     8461 ggctcgcaca cccggtgtca agttcggcgg atccaatacc cgttgtcaag ttcaacggac
     8521 cccatacccg gcgtcgacca accacccggc accaacgcac ccaaaacccc acaaccacga
     8581 cacacagggc ccgccagccc cgccgccgcc ccctaagaac tcctaacaaa acctgatctt
     8641 ggaataggtt gttcacttga gttgttgatc aggatgtgag gaagggtcag cggccaccct
     8701 ggatcgtgtc cgacgagttg tgggcacgta tcgagcctct actaccggtc gttccgcacg
     8761 atcctcgtca ccctggacgt cctcgactgg atgaccgcaa ggtgttgtgc ggcatcctgt
     8821 tcgtgctcta taccggcatt cagtgggagt tcctgccccg ggaactgggc ttcggctccg
     8881 gcatgaccgc ctggcgacga ctccgggact ggagcgccgc cggggtgtgg gaacgactgc
     8941 acgagaccct gctcgccgag ctgcacgcgg ccggcgcact ggactggtcg agggcggtga
     9001 tcgacagctc tcacgttcgg gccatgaaag gcggcccaaa accggaccga gcccggtcga
     9061 ccgtgcccga actggctcga agcaccatct gatcaccgaa gcgcacggta ttcccttgca
     9121 gttctcgctg accggcggca accgcaacga cgtcactcag ctgatgccgc tgatccagac
     9181 gatcccaccg gtgcgcggtc gccgtggccg accgcgacgg cggcccgaca cgctctacgc
     9241 cgaccgcggc tacgaccacg acaagtaccg cacacaggtg cgccacctcg ggatcacgcc
     9301 gttcatcgcc cgacgcggcg aggaacacgg ctcagggctg ggcgtgtacc gctgggtggt
     9361 cgagcagagc atcgcgctgc tgcactggtt ccggcgactg cgggttcgct gggagatccg
     9421 cgacgacatc cacgaggcct tcttgcgctt ggcatgcgcg atcatctgct tccgccgact
     9481 ggccagcctc ggactttgtt aggagttcta ggcccccggc accaccgcgt cccgcgaaga
     9541 tcgcagcccc gccaacagct gcgccgactc cttcgagtcc acctccgcca gcagcctcgc
     9601 cgcctgttcg atcttctccc cggccagcgc cgagtccccg tcgttcgtgt ggatctccga
     9661 caggagcacc agcgtccgcg cgtgccacag cgccgacccc agttcgtcga acagcctccg
     9721 cgcctccacc aggtgcgtca ccccggtcga gtcgccgccc cgcgccaacg cgatctcgcc
     9781 cagcccgtac agcgctttgg cctcgatcag ctgttcgccc acccgccgcg ccaggtccag
     9841 cgcgtggacg agcgtcgtct ccgcgttgtc gagccgccct tcccggtgtc gcagcaggcc
     9901 gagcccgtac agcgcgtgca cctccccgat ccggtcaccg gtgtcgcgga cgatgcgcag
     9961 cacccggtgc agcgcctgcc gcgcctcgtc gatctggccg gtggccaggt ggagctcggc
    10021 gaaccggtgc acgacctgcg cctcggtgcg caggcagtgg acctcctggc agatggccag
    10081 cgcgtcgtcg agcagctcgc gggccgtcgc ggtgtcgccc tcgtccatcc ggaacttcgc
    10141 catgctgcgc aggatgtgcg cctcgccgac ccggtcgccg accacgcgca tggtggcgag
    10201 cgactcggcg tacttctcga gcatcgacct gatgtcgccg cgcagcccgt cgatgtgggc
    10261 ggcgttgcgc agcaccaggg cgcagccgtg ggcgtcgcct tcggcgcgga agatccccaa
    10321 cgcggtggtg aagcactcgt ccgcctcggc gagccgggtc tggaacatgt gcagg
//
