LOCUS       NZ_PVTF01000011        29516 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Umezawaea tangerina strain DSM 44720 Ga0180964_111, whole genome
            shotgun sequence.
ACCESSION   NZ_PVTF01000011
VERSION     NZ_PVTF01000011.1
KEYWORDS    WGS; RefSeq.
SOURCE      Umezawaea tangerina
  ORGANISM  Umezawaea tangerina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Umezawaea.
REFERENCE   1  (bases 1 to 380540)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 380540)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Expected Final Version            :: No
            Genome Coverage                   :: 86.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003002815.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:47:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,483
            CDSs (total)                      :: 9,418
            Genes (coding)                    :: 9,322
            CDSs (with protein)               :: 9,322
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 20 of 97
            Pseudo Genes (incomplete)         :: 83 of 97
            Pseudo Genes (internal stop)      :: 2 of 97
            Pseudo Genes (multiple problems)  :: 8 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:41:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 77586
            Orig. end                         :: 107102
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVTF01000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..29516
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..29516
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..29516
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:19516]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..19516
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            379..1560
                     /locus_tag="CLV43_RS32680"
                     /old_locus_tag="CLV43_11171"
     CDS             379..1560
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV43_RS32680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV43_11171"
                     /product="hypothetical protein"
                     /protein_id="WP_146174984.1"
                     /transl_table=11
                     /translation="MSRIDRRTVLRGGAAVALWAATSTTPVAGRASATAPIGPGTPVAP
                     PELDSPTWNALPLLDRQVLTVLSQVFATFRAHARTIWGDYRPDRTQLVLPHWPGGEELP
                     GYAYVVNARRPGSLGDARPVDLPGALGLGAVHRITRGAGMDAALSPNGTIGTVDIAGVP
                     TLVVGFGTSEVIRGLLDFGTWLAARVLVHEAFHAYGSTWAPYPLPDGQTTQPSPADYPR
                     DAENAALALLEDAVLALPSDRPAPSAAGKLRGYLAIRAVRWDRLPEVAWREGPYQSGEG
                     TARFVEDRYVRLGGHQLADRSTDLTTGPALLAWIGRRRGYPVGASCGELLESAVGPWWR
                     TRAPSGRTPGDIAAEVLGVPTGEDRDRVVAEAKQAFDYAGLLDLVRRADLPHA"
     gene            complement(1576..2145)
                     /locus_tag="CLV43_RS32685"
                     /old_locus_tag="CLV43_11172"
     CDS             complement(1576..2145)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005152148.1"
                     /locus_tag="CLV43_RS32685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11172"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_106192089.1"
                     /transl_table=11
                     /translation="MTADKPLRADARRNRDAVLAKAREIADAGEFFDLRFDDFARLAGV
                     GIGTLYRQFPTREALAEAVYAKEITTLCDRARELGAALPAEEALAAFLRGMVDHMQAHQ
                     GLARTLAALMTTGSSTVADGGQALERAVTELVAAAVRDGAVRDDVDAGAVMMALHGIGA
                     AHDRPDWRTEADGVITLLLDGLRRTR"
     misc_feature    complement(2156..2171)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 24.05"
                     /tool="antismash"
     misc_feature    complement(2165..2179)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.85"
                     /tool="antismash"
     misc_feature    complement(2192..2206)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            2234..3193
                     /locus_tag="CLV43_RS32690"
                     /old_locus_tag="CLV43_11173"
     CDS             2234..3193
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228220.1"
                     /locus_tag="CLV43_RS32690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11173"
                     /product="2-dehydropantoate 2-reductase N-terminal
                     domain-containing protein"
                     /protein_id="WP_106192091.1"
                     /transl_table=11
                     /translation="MKILMFGRGVIATVYGWALEQAGHEVEFYVRPGRAAAHGDAVDLD
                     LLDARRRVLGERVALSWPARYREDLVPDHDYDLIVLSVQHYQLAEAAAALAPYVGNATV
                     LVFGNIWVEPWTAVEALPAGQVAWGAPQAGGGFDEDGVLRGLLLPSVVFGTFGTPPTER
                     ELAVRRVFRESGFRLKEQPDFRGWLWVHFAVGAGVQSQGLRRGSLAQLVGATGDLREAL
                     LTTRELLPLLRARGVDLRRHRGSVLLYRAPTWLTAPVFAWALTHVALARATFANHADPE
                     AEEPRAVCRDTLAEARRLGVPVPRLEAAEPGFARQAQG"
     gene            complement(3263..3676)
                     /locus_tag="CLV43_RS32695"
                     /old_locus_tag="CLV43_11174"
     CDS             complement(3263..3676)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020497411.1"
                     /locus_tag="CLV43_RS32695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11174"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_106192092.1"
                     /transl_table=11
                     /translation="MPHAPAVPDWLTRAFDRLAVGDVDGWADIYAPDAVHEIPFTADDV
                     PVRLVGRETIAARLREVYDADAGRLRFGSFDVLRLHEGGDEVVVEGVGRHRRAADDTPV
                     EIGCVWFITRHDGQVTHFRDYMNPAALAAHQLM"
     gene            3781..4332
                     /locus_tag="CLV43_RS32700"
                     /old_locus_tag="CLV43_11175"
     CDS             3781..4332
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020497412.1"
                     /locus_tag="CLV43_RS32700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11175"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_245887148.1"
                     /transl_table=11
                     /translation="MARILAAADGLFGAADTAGPITMDDIATAAGIGKGTLFRAFDSRD
                     GLLDALSDAKFAPVREALEGGRPPLGSEAPARERVVAFLDAVLTFKLDNRHLIRAREVS
                     STGALRTERYRWMQDALRALIADAMPGATAGDAGYAAHVLLAAIHIDLVEELLAGGRTP
                     ERIRRSQAALARAVLADVPG"
     gene            complement(4429..5019)
                     /locus_tag="CLV43_RS32705"
                     /old_locus_tag="CLV43_11176"
     CDS             complement(4429..5019)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037675.4"
                     /locus_tag="CLV43_RS32705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11176"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_106192094.1"
                     /transl_table=11
                     /translation="MAWDTEETKRRLRDAAVVEFAEHGFAGATTDRIARTAGVNKERLY
                     AYFGNKQGLWSTVIDSELERLAAAVPLTADSLRDIGSFAAALYDYHASHPHLGRLLQWQ
                     ELRAEDTSPDPATTVHYRRKVEVFAQAQRDGVVDPDVDPGMLMFSLIALAAWWQTAPRL
                     ARMVTGSGASARERKRRRDFVAEAARRMAHPHR"
     gene            5133..6074
                     /locus_tag="CLV43_RS32710"
                     /old_locus_tag="CLV43_11177"
     CDS             5133..6074
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (14-191). E-value: 3.7e-26.
                     Score: 83.9. Matches aSDomain:
                     nrpspksdomains_CLV43_RS32710_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226717.1"
                     /locus_tag="CLV43_RS32710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11177"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_106192096.1"
                     /sec_met_domain="ADH_N (E-value: 2.5e-07, bitscore: 25.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVGVTRFGGPDMLRVLEVGAEPLGRADVRVRVTAAAVNPTDTM
                     LIAGARADGDRPAGGVAVPGMDVAGVITEVGPDVPARLSPGARVMAIVVPSGDHGGYRE
                     ELVLPSASVTAVPLGCTDAEASTLPMNGLTARLALDLMRLRRGGTIAVTGAAGAFGGYL
                     VQLARHEGLTVVADAAPADRAMVAALGADVVVDRGPDVAARIRDHFPDGVDGLADGAVQ
                     GDEVLSAVRDGGVFATVRGYRGDGARGIRVAVVGVRDYAANWEKLDGLRELAGQGALTP
                     RVAGTLPLDQAAEAHRRLAAGGTRGRLVLLPE"
     aSDomain        5175..5705
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS32710_PKS_ER.1"
                     /evalue="3.70E-26"
                     /label="CLV43_RS32710_PKS_ER.1"
                     /locus_tag="CLV43_RS32710"
                     /protein_end="191"
                     /protein_start="14"
                     /score="83.9"
                     /tool="antismash"
                     /translation="LRVLEVGAEPLGRADVRVRVTAAAVNPTDTMLIAGARADGDRPAG
                     GVAVPGMDVAGVITEVGPDVPARLSPGARVMAIVVPSGDHGGYREELVLPSASVTAVPL
                     GCTDAEASTLPMNGLTARLALDLMRLRRGGTIAVTGAAGAFGGYLVQLARHEGLTVVAD
                     AAPADRAMVAALGA"
     CDS_motif       5325..5360
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CLV43_RS32710_0001"
                     /evalue="2.30E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="CLV43_RS32710"
                     /protein_end="76"
                     /protein_start="64"
                     /score="10.9"
                     /tool="antismash"
                     /translation="GMDVAGVITEVG"
     gene            complement(6181..6951)
                     /locus_tag="CLV43_RS32715"
                     /old_locus_tag="CLV43_11178"
     CDS             complement(6181..6951)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223388.1"
                     /locus_tag="CLV43_RS32715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11178"
                     /product="IniB N-terminal domain-containing protein"
                     /protein_id="WP_106192097.1"
                     /transl_table=11
                     /translation="MVTFETLQDFASHLLNDSQALSAFQADPEGVLQTAGLGDVSALDV
                     QEILPLVLDHSPVQGLGGVFGSLSSDNALDVLDSGALGLPDTSALTGVTATAQQLTSQF
                     SAVTDLGDGLDADVLGGSLDSVNDLTAHAKVTEVVHDITAQSQVTDLVGDLSSGADVLD
                     TTHVTGTVQDITTGLGTGDVLGGDLSGLTGTVTDNALHLGDIAQAGDVLGGVGHVGDVT
                     SALGGVSGIGDISHVADLGHLDVGDVLSDNAIAF"
     misc_feature    7168..7183
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.06"
                     /tool="antismash"
     gene            complement(7265..8587)
                     /locus_tag="CLV43_RS32720"
                     /old_locus_tag="CLV43_11179"
     CDS             complement(7265..8587)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1137: Major
                     facilitator superfamily MFS 1"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803123.1"
                     /locus_tag="CLV43_RS32720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11179"
                     /product="MFS transporter"
                     /protein_id="WP_106192099.1"
                     /transl_table=11
                     /translation="MSIDAPGTGTTGFGRLAAALLTSQFGVYIAIITPLQLLLALRLTA
                     LTSDTGAATDSFGLVTGLAAVVVLVSTPIAGRISDLAAFPLGRRRTWILFGALAGAAAV
                     VALGETSAVWQVVLLWCLAKALFSFQQSATTAVLADQVPPRRRGLASGLLGLVIPLAPL
                     LGLAIVTALPAGSALQWRVVAAIAAVAGVVSVLLIREGRPRPRRDGHGGIGVVLRTFWL
                     DPRRHPAFGWAWLVRFLITATYAAGSYVSLYLIQRFGVSQADVGGLVLTWSAILVPTAI
                     IASLGAGHLSDVLRRQKPFVVVSALIGVVAMALLAFAPSTSVVFVAAGVMGVGMGTFLA
                     VDMAMCVRVLPDGANAGKDLGIVNIANMLPQSLVPLSAPLLLGLGGYTAFFGFLALLGI
                     AGALAVRRVPEIGQEDGAPGVAPLDRDRPHRTPTRNAPGAS"
     misc_feature    8706..8720
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.33"
                     /tool="antismash"
     misc_feature    8715..8730
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.81"
                     /tool="antismash"
     gene            8852..9892
                     /locus_tag="CLV43_RS32725"
                     /old_locus_tag="CLV43_11180"
     CDS             8852..9892
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (6-319). E-value: 2.1e-47.
                     Score: 153.9. Matches aSDomain:
                     nrpspksdomains_CLV43_RS32725_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803122.1"
                     /locus_tag="CLV43_RS32725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11180"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_245887149.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.2e-46, bitscore:
                     153.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARIIHQLSLNENCSPPLPGVVEALSGALDQVHLTLDALADGLAA
                     DLAGRLGLDAGRVVAGAGSGALLQQFLTAHAGAGTTVVHTWPSFEMYPLLIRNALAEPV
                     AVTGPDDRQDLAAVAAAVTPDTSVVLLCNPNNPTGEVLDAARLRDLLDALPPHVLVLVD
                     EAYREFAAPDAIADAVELHRTDDRVAVVRTFSKSHGLLGLRVGYLVGAAEVVAPVRRTT
                     PFYRVPTIAQAAAVAALKAEPEMREQCERVAAERDRVRSGLLDLGFDVPPSGGNFLWLR
                     LGARNREFVEHLAEDGIAVRALAGGSGVRVSTGIPEANDAVLRAAGRFAAGLAAARTTP
                     ASTDHR"
     aSDomain        8870..9808
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS32725_Aminotran_1_2.1"
                     /evalue="2.10E-47"
                     /label="CLV43_RS32725_Aminotran_1_2.1"
                     /locus_tag="CLV43_RS32725"
                     /protein_end="319"
                     /protein_start="6"
                     /score="153.9"
                     /tool="antismash"
                     /translation="QLSLNENCSPPLPGVVEALSGALDQVHLTLDALADGLAADLAGRL
                     GLDAGRVVAGAGSGALLQQFLTAHAGAGTTVVHTWPSFEMYPLLIRNALAEPVAVTGPD
                     DRQDLAAVAAAVTPDTSVVLLCNPNNPTGEVLDAARLRDLLDALPPHVLVLVDEAYREF
                     AAPDAIADAVELHRTDDRVAVVRTFSKSHGLLGLRVGYLVGAAEVVAPVRRTTPFYRVP
                     TIAQAAAVAALKAEPEMREQCERVAAERDRVRSGLLDLGFDVPPSGGNFLWLRLGARNR
                     EFVEHLAEDGIAVRALAGGSGVRVSTGIPEAN"
     misc_feature    8873..8875
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8874..8891
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 18.77"
                     /tool="antismash"
     misc_feature    8882..8897
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.65"
                     /tool="antismash"
     gene            10001..11692
                     /locus_tag="CLV43_RS32730"
                     /old_locus_tag="CLV43_11181"
     CDS             10001..11692
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803121.1"
                     /locus_tag="CLV43_RS32730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11181"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_106192102.1"
                     /sec_met_domain="T2TS (E-value: 6.4e-38, bitscore: 124.9,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVHVDPDPFTEVLEAAIAEGAEVLFGAQRDDGVFDYGEDSLTS
                     TLGTVGAVSALHFADPVGSADLIAAGAGWLRRTQNEDGGWAMVPGLPSEAGPTAVASAV
                     LHLVDPEGSATPVATGQRWMDDHGGLDAIPHPEVVSWCRQYYGFVGWLAPEDMRRFPLE
                     LALLPGLYRRLFDLRLPMASALGLAQARHKPLTRLQRALARWGEPNALKVVRQVYEHEG
                     STGAWCENAWVTGLVCTGLARAGLAPDMVAAAVGWFHRSMAPDGSWETGPLDAAWTMYA
                     ARGLAEAGYAGDPRLAASVRLFVRIQQHRPFLAFGCPPGYWGWSGTEGWPSTLETGEVL
                     SVLCRLPGDEQADAVRRGVDWLTRVQDTRGSWGLCVRNTKVANSGPCPMTTVQAVDALL
                     DAGVPAGDRRVRRALGWLARVQSPEGTFESVWYRHHTMGTAAVLETFSRVGRAADEPAR
                     RAVAWLERTRLPDGSWGDGSGAPGTVEETGWAVSSLLAAGADPATVRSGVDWLLARRRP
                     GGGWPSENVHEYVRFVSRYSNPAFAHGMALRALGRYRTATRRDTTS"
     gene            11736..12950
                     /locus_tag="CLV43_RS32735"
                     /old_locus_tag="CLV43_11182"
     CDS             11736..12950
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018332752.1"
                     /locus_tag="CLV43_RS32735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11182"
                     /product="cytochrome P450"
                     /protein_id="WP_106192104.1"
                     /sec_met_domain="p450 (E-value: 2.1e-18, bitscore: 60.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTTHEDSFTEDYWRDPHETLARTRETSPVREVEFETGPTWLVT
                     RYADVRAGLTDERLAKDWRSSLPEEERASAPPGLPAPMSHMLTSLDPPEHTRLRNLVVQ
                     AFTARRIAELRPRVEAVAAELLDALPEHEPVDLVARYAIVLPMVVICELLGVPEIDREE
                     FARLSTVLIDECPEPEMVLASTRMADYLEGLVAAKRAAPDSALLSALITASDEGDRLSD
                     LEIVAMAMLLLMAGHETTAVFITNSVRALLADPAGLDRLASPASAPSLVEELLRWLSPA
                     INASLRFATEDLEIGGVAIRRGESVMLSTGGANRDPAQFPEPTRFDPDRDTAGHLAFGH
                     GIHRCLGAALVRLEGEVGLSALFSRFPLMRAAADPADLTFRRSVHVHAPRTFPVVLGPR
                     TEPGE"
     gene            complement(13036..13869)
                     /locus_tag="CLV43_RS32740"
                     /old_locus_tag="CLV43_11183"
     CDS             complement(13036..13869)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (3-248). E-value: 2e-57. Score:
                     186.9. Matches aSDomain:
                     nrpspksdomains_CLV43_RS32740_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803119.1"
                     /locus_tag="CLV43_RS32740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11183"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_106192105.1"
                     /sec_met_domain="TauD (E-value: 1.1e-56, bitscore: 186.9,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFQVRPISGSLGAEVYGVDLGSVDDEQFKEVHDLLMRHLVLFFP
                     DAGGLTPQAHEAFGSRFGQLEVHPFLPKLEGHDKIVVLDSEQGARADVWHTDVTFAQSP
                     PIASVLQITLTPESGGDTMWSNQYLAYEALSEPIRDLLEGTTASHLFVHPNGTFRSEAE
                     HPVVRTHPVTGRRSLYVNRMFTRRILQLSKGESDALLEHLFAVSESPQRTCRYRWVEGA
                     VAMWDNRATQHYAVNDYAGRRVGQRVTVMGDEPRGAEPRWGRFQEAGMSATTVKE"
     aSDomain        complement(13126..13860)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS32740_TauD.1"
                     /evalue="2.00E-57"
                     /label="CLV43_RS32740_TauD.1"
                     /locus_tag="CLV43_RS32740"
                     /protein_end="248"
                     /protein_start="3"
                     /score="186.9"
                     /tool="antismash"
                     /translation="QVRPISGSLGAEVYGVDLGSVDDEQFKEVHDLLMRHLVLFFPDAG
                     GLTPQAHEAFGSRFGQLEVHPFLPKLEGHDKIVVLDSEQGARADVWHTDVTFAQSPPIA
                     SVLQITLTPESGGDTMWSNQYLAYEALSEPIRDLLEGTTASHLFVHPNGTFRSEAEHPV
                     VRTHPVTGRRSLYVNRMFTRRILQLSKGESDALLEHLFAVSESPQRTCRYRWVEGAVAM
                     WDNRATQHYAVNDYAGRRVGQRV"
     gene            14040..15032
                     /locus_tag="CLV43_RS32745"
                     /old_locus_tag="CLV43_11184"
     CDS             14040..15032
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803118.1"
                     /locus_tag="CLV43_RS32745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11184"
                     /product="methyltransferase"
                     /protein_id="WP_106192107.1"
                     /transl_table=11
                     /translation="MTAQDELAKMVDLATPFAVRVAVTLHLPELIDGGTTGLAELAASA
                     GAVPDALRRLLDHLTSIGFFARPRPGVYALTDVSRLLLSEDYGAARSWLDSEGPGARMD
                     LAFAGMAHSVRTGKSAYGVVHGVPFWDDYGADEELRVFFGGIMAVHAWQTGPVVATEVD
                     WTSSRRVLDVGGGVGALLAEVLKANRHLTGAVLDLPPVEPDATTALKEAGVSDRAGFVP
                     GSFFDPLPTGYDTYVISRVVTDWDDEDALRIMTRAAEAVGTGRVLVVEVLAGQEHAKNN
                     SSFDLQSLALLGGRERSEEDFVALAGRAGFATATARRWDSGLLVVECGL"
     misc_feature    14082..14097
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            complement(15140..16405)
                     /locus_tag="CLV43_RS32750"
                     /old_locus_tag="CLV43_11185"
     CDS             complement(15140..16405)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803117.1"
                     /locus_tag="CLV43_RS32750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11185"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_106192109.1"
                     /transl_table=11
                     /translation="MSTDVDVVVCGAGVAGLAAAHALGGLGLRVLVLDKQRAVRAVPKG
                     ELLQPGAAGVLAHWGVVDELDADGALRLSGLVARDPHGAALMTMDYRTLPTERPWLLVH
                     DYHVILGALSRTLPAGVELRRGVLVRELLRDENGRTTGVRTDGGDLTAALVVAADGVSS
                     RLRRASGIEVVRTDYEHRLAAFELTGQAPGDDVSTYATPRGLAMRYPLPGGRARLYVQV
                     GPDELRGVDATAAAGWVDGLVRDVPAFAPLREDVARAWPTRQVLPVGRALATSLTADGL
                     VLIGESAHAVHPAAGQGMNSSILDAASLATRLRPLDGDLSPDLLRPRLREWSAERRQAL
                     AHVGTTSHNATRMISDLSPLVRVLGRRALRKTGGNRRLRYTIMHNMAGLGQHPLTPLDR
                     LHQLGVLPDPRGGRLPGWARSR"
     gene            complement(16446..17429)
                     /locus_tag="CLV43_RS32755"
                     /old_locus_tag="CLV43_11186"
     CDS             complement(16446..17429)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ubiA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803116.1"
                     /locus_tag="CLV43_RS32755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11186"
                     /product="UbiA family prenyltransferase"
                     /protein_id="WP_106192110.1"
                     /sec_met_domain="ubiA (E-value: 1.6e-16, bitscore: 54.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATWRRTVEAHVQTWRPYTLPYPGVVGLAGASVAGGHPEPRHLVA
                     AVLIPVLVWLGGHYLGDWLDRDLDAIDKPQRPIPSGRLGPRAALLSAVVCEVVAAAAAA
                     VAGWRVLVLLVVGVAGIAAYSRLCKGRGISGNLVRGALTSLAVLAGATCVPDGRVWTAV
                     PFAVVFLLHDAASNLVGAVRDVEGDEAGGYRSVPVQRGVAYGARLAQALYGSALVAAVA
                     SVLVPLPDRTSYLTLLVVATAIGAWVFGGLLTQGDGITRESALRAHEVLVAERLVLACA
                     VTAAGAGAPVAVAVLLPVVAFSVVTQHAMRARHEIPPAGLRRATAS"
     gene            complement(17432..19516)
                     /locus_tag="CLV43_RS49610"
                     /old_locus_tag="CLV43_11187"
     CDS             complement(17432..19516)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (43-356). E-value: 3e-45.
                     Score: 146.8. Matches aSDomain:
                     nrpspksdomains_CLV43_RS49610_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012382.4"
                     /locus_tag="CLV43_RS49610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11187"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_245887150.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.6e-44, bitscore:
                     146.9, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.4e-10,
                     bitscore: 35.3, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.4e-53, bitscore:
                     176.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHPPSQEAVNSVEVVRNAFDVFLTARPVNGDLSVPNIVHQLSLN
                     ENFAPPLPGVREAVIAAADNSHLTLDAMSDGLTAAIAAHLGVPASEVLVGAGSGAVLQQ
                     LLDGTAGPGDEVVHASPSFWGYGPLVRNTGATPVVLPLADGYGTDVDATAAAVTPRTRA
                     VLLCNPNNPTGSVLGHAEVRRLLDALPPDVLLVVDEAYREFSDPAEIADALALHREDPR
                     VVVVRTFSKSHGLLGLRVGYLVAAERVVTPLRGTAPFFRVSTVAQAAAIAALAAEDRMR
                     AQCAAVRVERDRLRTALLDHGLPVPPSAGNYLWLPLGAEGPPLVEFLAEHGVAVGDVGG
                     LGVRVTVGTREANDAVIALVGEYTRKGFSPAAEAVVSRLREALHGEWPEQDDPVLAISR
                     YALLIPGKLLRPLLLTAAAGAVGGDVEQVVPAALAVEYLHVGSLVHDDVIDGDETRRGR
                     PSVQHRFGVPDAIVTGDALMMRTFGSVTTCVDRGVPEAAALRAVRAISDAAVDVCRGQA
                     LEGAMATDPSRPLAEYVTVMALKTGALFRGACRAGAVLGGAEPAVVDAVGQYAEHLGLA
                     FQMHDDLLPYLSDPAVTGKSGLSDLRNLRPTYPVLLAHETGTPEQRARVVGALSGELTP
                     EEAFTALRDVLDETGALKRAVEHAEAEVALAKSYLADLPANEHTAMLAEVADMSVDRRR
                     "
     aSDomain        complement(18449..19387)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS49610_Aminotran_1_2.1"
                     /evalue="3.00E-45"
                     /label="CLV43_RS49610_Aminotran_1_2.1"
                     /locus_tag="CLV43_RS49610"
                     /protein_end="356"
                     /protein_start="43"
                     /score="146.8"
                     /tool="antismash"
                     /translation="LNENFAPPLPGVREAVIAAADNSHLTLDAMSDGLTAAIAAHLGVP
                     ASEVLVGAGSGAVLQQLLDGTAGPGDEVVHASPSFWGYGPLVRNTGATPVVLPLADGYG
                     TDVDATAAAVTPRTRAVLLCNPNNPTGSVLGHAEVRRLLDALPPDVLLVVDEAYREFSD
                     PAEIADALALHREDPRVVVVRTFSKSHGLLGLRVGYLVAAERVVTPLRGTAPFFRVSTV
                     AQAAAIAALAAEDRMRAQCAAVRVERDRLRTALLDHGLPVPPSAGNYLWLPLGAEGPPL
                     VEFLAEHGVAVGDVGGLGVRVTVGTREANDAV"
     misc_feature    complement(19570..19585)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.71"
                     /tool="antismash"
     misc_feature    complement(19571..19588)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.86"
                     /tool="antismash"
     misc_feature    complement(19764..19778)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.1"
                     /tool="antismash"
     misc_feature    19791..19807
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.91"
                     /tool="antismash"
     gene            complement(19977..20252)
                     /locus_tag="CLV43_RS32770"
                     /old_locus_tag="CLV43_11188"
     CDS             complement(19977..20252)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV43_RS32770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV43_11188"
                     /product="hypothetical protein"
                     /protein_id="WP_106192112.1"
                     /transl_table=11
                     /translation="MVRTEEQPLVRRAPRTPAPRPTRRRPVAGIDRHRRTAHVEPPRPF
                     RLSRRVKWVLLAVAAAFFTAGVVVPHALLIAAGLILAGTVGVGGSH"
     gene            20488..21441
                     /locus_tag="CLV43_RS32775"
                     /old_locus_tag="CLV43_11189"
     CDS             20488..21441
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010312008.1"
                     /locus_tag="CLV43_RS32775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11189"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_106192114.1"
                     /transl_table=11
                     /translation="MSLFGRIFLLNAVAMVAAVALLVLGPITVSTPALLAEILILVAGL
                     AVLLVANAALIRLGLAPLERLTRAMTTIDLLKPGPRLTASGHGEIADLITTFNGMLDRL
                     EAERGSSSARALSAQEAERRRVAQELHDEVGQSLTAVLLDLKRVADRAPAPTGDELRQV
                     QETVRSTLDEVRRIARRLRPGVLEELGLVSALTALAAEISEHTDVAVRRTFDRHLPDLD
                     EETELVVYRVAQEGLTNTVRHAGARRVELLLRSTSAGVELCVRDDGEGLGDSVEGAGIR
                     GMRERALLVGADLAVGPAPRRGTEVRLVVRTSGRAS"
     gene            21438..22100
                     /locus_tag="CLV43_RS32780"
                     /old_locus_tag="CLV43_11190"
     CDS             21438..22100
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020501316.1"
                     /locus_tag="CLV43_RS32780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11190"
                     /product="response regulator transcription factor"
                     /protein_id="WP_106192115.1"
                     /transl_table=11
                     /translation="MTPGTRPVRILLADDHALVRRGVRLILDNEPDLTVVGEAGDGAEA
                     IAMARADLPDLAILDIAMPRLTGLQAARELSRLLPDLRILILTMYDNEQYFFEALKSGA
                     SGYVLKSVADRDLVEACRAAMRGEPFLYPGAVASLIRNYLDRVHDGESVPAKAITDREE
                     EILKLVAEGNSSKEIADLLFISVKTVERHRANLLQKLGLKDRLALTRYAIRAGLIEP"
     gene            22131..22604
                     /locus_tag="CLV43_RS32785"
                     /old_locus_tag="CLV43_11191"
     CDS             22131..22604
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006813 - potassium ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020640229.1"
                     /locus_tag="CLV43_RS32785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11191"
                     /product="TrkA C-terminal domain-containing protein"
                     /protein_id="WP_106192117.1"
                     /transl_table=11
                     /translation="MDVEVTPLPGIGVREDFATRAGRRIGVVSHRDGKFELIVARQDDP
                     DAAVASIPLTPEEAVTLAGLLGSPQLVSRLSEQHRDISGITTRQLPVVAYANRTLGDTA
                     LRTRTSASVVAVVRAGVAHPSPGPEFLFHTGDLAVVVGTAEGLTAAADILTGG"
     gene            22609..23793
                     /locus_tag="CLV43_RS32790"
                     /old_locus_tag="CLV43_11192"
     CDS             22609..23793
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800450.1"
                     /locus_tag="CLV43_RS32790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11192"
                     /product="cation:proton antiporter"
                     /protein_id="WP_106192118.1"
                     /transl_table=11
                     /translation="MQETAIALIQLGAVFFGLGLLGRVAWKFGISPIPLYLVGGLAFGS
                     GGLIPLHGIDEFTHLASEIGVVLLLLLLGLEYSASELTTGLRKSWTAGLVDIALNAVPG
                     AAAALLLGWGPVGALAMAGVTYISSSGIIAKVLGDLGRLGNRETPVVLSVLVFEDLAMA
                     VYLPVLTAVLAGASLLGGLTSVGISLLAVTVVLVVALRYGRFISAVVDSPDHEVFLLKV
                     LGSALLVAGIASQLQVSAAVGAFLLGIAISGSTAENATRMLEPLRDLFAAMFFVVFGLN
                     TNPSSIPPVLGVAAALALVTTATKIATGWWAAKRQGIAAMGRARTGAALVARGEFSIVI
                     AGLAVASGHVQDELAALATAYVLLMAIIGPIVARYVEPVSGFLLRDRSKSGAHG"
     gene            complement(23744..25309)
                     /locus_tag="CLV43_RS32795"
                     /old_locus_tag="CLV43_11193"
     CDS             complement(23744..25309)
                     /EC_number="1.14.13.127"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF004829.0"
                     /locus_tag="CLV43_RS32795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11193"
                     /product="bifunctional
                     3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid
                     hydroxylase"
                     /protein_id="WP_106192120.1"
                     /transl_table=11
                     /translation="MTDDVVDVAVVGAGPVGLTLAALLGQAGRSVVVLERHPALYGLPR
                     AASFDGEVLRLLAGLGLAEELLPTLHVQEAYQWSDAAGEVLLSLESRLVGDSGWPDLLM
                     FHQPVLERALHARCGSLPSVEVRLGAAVTGLDRAEDEVRLVTAEGGTVRARYVVGCDGG
                     NSFVRTALGIDEDDLGFAEPWLVCDFVLRRPAAELGLPSALQVGDPDGPTTIFTTGAGR
                     QRFCFMLDDADVGREIADAEVWRRVERHLTPADADVERVATYTFRSLVARRWRDGRVLL
                     AGDAAHRMPPFLGQGMCSGMRDAANLAFKLDLVSTGAQDPGVLDTYQSEREPHVRALTA
                     TSIALGRRHTLTDHALARERDDAMRATRDSLREPERIRLPDLGPGLHGPGGGALSVQGR
                     VDDGRRAGLLDQVVGGGFRLLLLGDDFPDVDVTALRAAGVTTTGIGKSAGDGVVADLDG
                     TLHRWFDRLGATAVAVRPDHYVLAAGPDAGEVARALLRVVAPPVAGSVSRARRSSTGRA
                     AGTR"
     gene            complement(25345..26307)
                     /locus_tag="CLV43_RS32800"
                     /old_locus_tag="CLV43_11194"
     CDS             complement(25345..26307)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (13-244). E-value: 3.8e-39.
                     Score: 126.6. Matches aSDomain:
                     nrpspksdomains_CLV43_RS32800_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020495706.1"
                     /locus_tag="CLV43_RS32800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11194"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_106192122.1"
                     /sec_met_domain="ADH_N (E-value: 2.4e-10, bitscore: 34.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.1e-14, bitscore:
                     49.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRIVRPTAYGSPDVLAVTEVPTPRAAADGVVVEVRAAGVNPVDW
                     KLYSGTFHAVAEDLKDAAGIAASMPSVGLECAGVVTEVGRDVTGVRVGDEVIVYPVTAA
                     YADRVTAPATSVLPKPAGLGWAEAGSLMLTGTTAVHALHAAGVGAGDTVLVHGGSGGVG
                     LMGVQLAAAAGATVIATAAERNHALLRELGAVPVVYGAGLADRVRAVAPRGVDAAVDFA
                     GTDEALDVSLELVADRTRIASIAGSPRRAAAGIAVLGYGPGQDAGTEVRTAARGQLVEQ
                     AGSGALRVVVATTFPLDEAAKAHEVGLAGHAPGKLVLIP"
     aSDomain        complement(25576..26268)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS32800_PKS_ER.1"
                     /evalue="3.80E-39"
                     /label="CLV43_RS32800_PKS_ER.1"
                     /locus_tag="CLV43_RS32800"
                     /protein_end="244"
                     /protein_start="13"
                     /score="126.6"
                     /tool="antismash"
                     /translation="DVLAVTEVPTPRAAADGVVVEVRAAGVNPVDWKLYSGTFHAVAED
                     LKDAAGIAASMPSVGLECAGVVTEVGRDVTGVRVGDEVIVYPVTAAYADRVTAPATSVL
                     PKPAGLGWAEAGSLMLTGTTAVHALHAAGVGAGDTVLVHGGSGGVGLMGVQLAAAAGAT
                     VIATAAERNHALLRELGAVPVVYGAGLADRVRAVAPRGVDAAVDFAGTDEALDVSLELV
                     ADRTRIASI"
     CDS_motif       complement(25771..25860)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CLV43_RS32800_0002"
                     /evalue="1.60E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="CLV43_RS32800"
                     /protein_end="179"
                     /protein_start="149"
                     /score="23.8"
                     /tool="antismash"
                     /translation="GDTVLVHGGSGGVGLMGVQLAAAAGATVIA"
     CDS_motif       complement(26056..26091)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CLV43_RS32800_0001"
                     /evalue="7.90E-05"
                     /label="PKSI-ER_m2"
                     /locus_tag="CLV43_RS32800"
                     /protein_end="84"
                     /protein_start="72"
                     /score="15.3"
                     /tool="antismash"
                     /translation="GLECAGVVTEVG"
     gene            26483..27418
                     /locus_tag="CLV43_RS32805"
                     /old_locus_tag="CLV43_11195"
     CDS             26483..27418
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1125: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224405.1"
                     /locus_tag="CLV43_RS32805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11195"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_245887151.1"
                     /transl_table=11
                     /translation="MGTVVAEDLDLNLLRVFDALMDTGSVAKAAERLHLSAPATSRALG
                     RLRRALNDPILVRAGRGLVPTPFALRSTGTVRALLDAADRLRTGPADTDPRSWRRTFSI
                     RLNDGLVPVVAPRLTRRIAAEAPDVRLRFVPQDSKDPDPLRDGSIDLDVTVAGPPPPDV
                     HTSTLFTDHFVAVVAADSDLGRAPRLTLDDLCHHPHVSASRRGLARGPLDDALEPLGRS
                     RHVSAVVPTYAVGALMALEQDLICLVPHVTATHLVDRGVPLRLHDVPVTLPTADVELRW
                     HRRVDDDPASRWLRTHLHDTIRPLAAVPRG"
     gene            complement(27432..29015)
                     /locus_tag="CLV43_RS32810"
                     /old_locus_tag="CLV43_11196"
     CDS             complement(27432..29015)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038357.1"
                     /locus_tag="CLV43_RS32810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11196"
                     /product="CATRA conflict system CASPASE/TPR
                     repeat-associated protein"
                     /protein_id="WP_106192123.1"
                     /transl_table=11
                     /translation="MTTPGPAEQELVVHLYVPSRGEHADAAIGGVKAIWARCRDLLGAT
                     EPVPRVGLPTTPPADVRGEPDGALAAAQNGAVDVQVVLRRAGAVLALSLIFAVPGTPGL
                     GAAAPPGWIEFDRWCDEVVGADAGSALGVVRVHQAKQPADDVRAWLPERLRDVVRWQRR
                     RRFLVWEPVDDVGRSRDLVVIAAEGEDDELTAWTWSRGGSEMPPLGRYLLHASLLRHHV
                     RVWRRDEPWLAGLREQVDGHVVESRDDPASAVDELRRDEIGLRVAGDRVERMRTSVETT
                     RTNMAALEPDLLPADVGLADWFLATLDDSLLGLTRGRALAAEVRGLSTRPEAAGHPTGR
                     RMRTGFVIDVVDYGRRSTPDQELVQRRMVALVEGVLDDLDVRLPEADHQGTGDGLMVFL
                     PERVDVQRALPRLLRGAAERLGRDNTVHRDRVRLRMAVDVGPVGLAALGFGGKVATSLG
                     RLLDSPPLRRAVLDHPDVDLAIVLSDRLHGYVVAEGVPGVDPDEFVPVDVEVKTFRDRA
                     WLWMARPATP"
     gene            complement(28993..29301)
                     /locus_tag="CLV43_RS32815"
                     /old_locus_tag="CLV43_11197"
     CDS             complement(28993..29301)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042470.2"
                     /locus_tag="CLV43_RS32815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_11197"
                     /product="CATRA system-associated protein"
                     /protein_id="WP_106192125.1"
                     /transl_table=11
                     /translation="MLEREARNDALDVLDDLLGWELPSDRWPEVSARLTALAAAVRAND
                     SAGVTAATVQLELISPLMGPGMGKEPTVPPTDAVREQQAEIVDSLRDKPDDDHPRTG"
ORIGIN
        1 cccagtacga cggcgggccc gcgatggccg cgaggctcgg cgaccagctg gtctccgtgc
       61 gggacagcgg gcagcacggc cactacggca ccaacccctg cgtcacggcc aggatcgacg
      121 cctacctgat cggtggcgtg ctcccgccgt cgaggtcgga gtgcgccgac gacccgcgtc
      181 ccccggtccc ggccgacggt tcgggggagg ccaggagcgc cgcgcgggag gacaaggcgg
      241 accgcgtccg ggccgccgtc ggcaccacct tctggcggta gcggcggacc ggctgtccga
      301 cctcttagga cagtcggtcc accggccgcc gcacccgcaa cgggatccac ccgatgtcca
      361 cgatggaggg acaggtcaat gtcacggatc gatcgtcgaa cggttctccg cggaggcgcc
      421 gcggtcgcgt tgtgggcggc gacgtccacc accccggtgg cggggcgggc gtcggcgaca
      481 gcgccgatcg gccccggcac gccggtggcg ccgccggagc tcgactcgcc gacgtggaac
      541 gccctgccgc tgctcgaccg ccaggtcctc acggtgctga gccaggtctt cgcgacgttc
      601 cgcgcgcacg cgcggacgat ctggggcgac taccggcccg accggaccca gctggtcctc
      661 ccgcactggc cgggcggcga ggagctgccc ggctacgcct acgtggtcaa cgcacgacga
      721 ccagggtcgt tgggcgacgc ccggcccgtg gacctgcccg gagcgctcgg actcggtgcg
      781 gtgcaccgca tcacccgcgg cgcggggatg gacgccgcgc tgtcgcccaa cggcaccatc
      841 gggaccgtcg acatcgcggg cgtgcccacg ctggtcgtcg ggttcggcac gtccgaggtc
      901 atcaggggcc tgctggactt cggcacgtgg ctcgccgcga gggtcctggt ccacgaggcg
      961 ttccacgcct acgggtccac gtgggcgccg tacccgttgc ccgacgggca gacgacgcag
     1021 ccgtccccgg ccgactaccc ccgtgacgcc gagaacgcgg cgttggcgct gctggaggac
     1081 gcggtgctgg ccctgccgtc ggaccggccc gccccgagcg cggccgggaa gctgcgcggc
     1141 tacctggcca tccgcgcggt ccgctgggac aggctgccgg aggtggcctg gcgggaaggt
     1201 ccctaccagt ccggggaggg cacggcccgc ttcgtcgagg accggtacgt gcggctgggc
     1261 ggccaccagc tcgccgaccg gtccacggac ctcacgaccg gcccggcact gctggcctgg
     1321 atcggcagga ggcgcgggta ccccgtcggc gcgtcctgcg gcgagctgct cgagtccgcg
     1381 gtggggccgt ggtggcggac cagggcgccc agcgggcgga ctccaggcga catcgcggcc
     1441 gaggtcctgg gcgtgccgac gggggaggac cgcgaccgcg tggtcgccga ggcgaagcag
     1501 gccttcgact acgccggact gctcgacctg gtgcgtcgag ccgatctgcc ccacgcgtga
     1561 gacggggcag ggggctcagc gcgtccggcg cagcccgtcc agcaggagcg tgatgacgcc
     1621 gtcggcctcg gtccgccagt cggggcggtc gtgggcggcc ccgatcccgt gcagcgccat
     1681 catcacggca ccggcgtcca cgtcgtcgcg gacggcaccg tcccgcacgg cggcggccac
     1741 cagctcggtg acggcccgct ccagcgcctg accgccgtcg gcgacggtgc tcgaaccggt
     1801 ggtcatgagc gcggccagcg tccgggcgag gccctggtgg gcttgcatgt ggtcgaccat
     1861 gccgcggagg aaggccgcca aggcctcctc cgcgggcagg gcggccccca gctcgcgggc
     1921 ccggtcgcac agcgtggtga tctccttggc gtacaccgcc tcggccagcg cctcgcgggt
     1981 ggggaactgg cggtagagcg tgccgatgcc cacgcccgcg agccgggcga agtcgtcgaa
     2041 gcgcaggtcg aagaactccc cggcgtcggc gatctcgcgt gccttggcca gcacggcgtc
     2101 gcggttgcgc cgggcgtcgg cgcgcagcgg cttgtcggcg gtcacgagcc ctccggttga
     2161 caagtggaaa caatctccat attttcgaaa gtggagatga actccagttc aatcctaccc
     2221 cacgaggtgc gtcgtgaaga tcctgatgtt cggccgaggc gtgatcgcca cggtgtacgg
     2281 ctgggccctg gagcaggccg ggcacgaggt cgagttctac gtccgacccg gccgggcggc
     2341 ggcccacggg gacgcggtcg acctcgacct gctcgacgcg cgacgacgcg tgctggggga
     2401 gcgcgtcgcc ctgtcgtggc ccgcgcgcta ccgcgaggac ctggtgccgg accacgacta
     2461 cgacctgatc gtgctgagcg tccagcacta ccagctcgcg gaggcggcgg ccgcgctggc
     2521 gccgtacgtc ggcaacgcca ccgtgctcgt gttcggcaac atctgggtcg agccgtggac
     2581 cgcggtcgag gccctgcccg ccggtcaggt cgcctggggc gcgccccagg cgggtggcgg
     2641 cttcgacgag gacggtgtgc tccgcgggct gctgctgccc tcggtcgtgt tcggcacgtt
     2701 cggcacgccc ccgaccgaac gcgagctggc cgtgcgccgg gtgttccgcg agtccgggtt
     2761 ccggctcaag gagcagcccg acttccgcgg ctggctgtgg gtccacttcg cggtgggcgc
     2821 gggcgtgcag tcgcagggcc tgcggcgggg ctcgttggcg cagctggtgg gcgcgacggg
     2881 tgacctgcgc gaagcgctgc tgaccacccg cgagctcctg ccgctcctgc gggcgcgcgg
     2941 cgtcgacctg cgccgccacc ggggcagcgt gctgctctac cgcgcgccca cctggctgac
     3001 cgcccccgtg ttcgcctggg cgctcaccca cgtcgcgctg gcgcgggcga ccttcgcgaa
     3061 ccacgccgac cccgaggcgg aggagccgcg cgcggtgtgc cgggacacct tggcggaggc
     3121 acggcggctg ggcgtcccgg tcccgcggct ggaggcggcc gaaccggggt tcgcccgcca
     3181 ggcgcagggg tgaaccgggc cgcgcgccga ggccgtccgg cgcggggcgt tcgcggaacc
     3241 cccgtcccgc ggaggcgtgc ggtcacatca gctggtgcgc ggccagcgcc gccgggttca
     3301 tgtagtcgcg gaagtgcgtc acctgcccgt cgtgccgggt gatgaaccag acgcagccga
     3361 tctcgacggg ggtgtcgtcg gcggcgcggc ggtggcgccc cacgccctcg acgacgacct
     3421 cgtcgccgcc ctcgtgcagc cggaggacgt cgaaggaccc gaagcgcagg cgtcccgcgt
     3481 cggcgtcata gacctcgcgc agccgggcgg cgatcgtctc ccggcccacg agccggaccg
     3541 ggacgtcgtc cgcggtgaag gggatctcgt gcacggcgtc gggggcgtag atgtccgccc
     3601 agccgtcgac gtcgccgacg gcgaggcggt cgaacgccct ggtcaaccag tcgggaacag
     3661 cgggtgcgtg tggcacggtt acctccacta gaatttcgga ctgtgagtcc agaaaaccgt
     3721 agcagacttt cggaccagca gtccgaaaag caggtccggc gtggtcgccc cccggtcccc
     3781 gtggcgcgca tcctcgcggc ggccgacggg ctcttcggcg ccgccgacac cgcgggtccg
     3841 atcacgatgg acgacatcgc caccgcggcg ggcatcggca aggggaccct gttccgggcg
     3901 ttcgacagcc gtgacggcct gctcgacgcg ttgtcggacg cgaagttcgc gccggtgcgg
     3961 gaggcactgg agggtgggcg gccgccgttg gggtccgagg cgcccgcacg cgagcgggtc
     4021 gtcgccttcc tcgacgcggt gctcaccttc aagctcgaca accgccacct catccgcgcc
     4081 cgcgaggtgt cctccaccgg ggcgctgcgc accgagcgct accggtggat gcaggacgcg
     4141 ctgcgcgcgc tgatcgccga cgcgatgccc ggtgccacgg cgggcgacgc cgggtacgcc
     4201 gcccacgtcc tgctcgcggc gatccacatc gacctggtcg aggaactgct cgccggtgga
     4261 cgcacgcccg agcggatccg ccgctcgcag gcggccctcg cgcgagcggt gctcgccgac
     4321 gtgccgggct gacgcgtccg ggtcgtcgcg gacgcacggt tccaaccgga cggttggacg
     4381 atgtccgcac cgcgtcggcg gtcggtggcg agttcttgcc ggcgaccgtc agcggtgcgg
     4441 atgtgccatc cggcgtgccg cctcggccac gaagtcgcgg cgccgcttgc gttcgcgggc
     4501 cgaggcgccg gagccggtga ccatccgggc cagtcgcggc gcggtctgcc accacgcggc
     4561 cagggcgatg agggagaaca tcagcatgcc ggggtcgacg tcggggtcga cgacaccgtc
     4621 gcgttgcgcc tgggcgaaaa cctcgacctt gcgccggtag tggacggtcg tcgccgggtc
     4681 gggcgacgtg tcctcggcgc gcagctcctg ccactgcagc agtcggccga ggtgcgggtg
     4741 gctcgcgtgg tagtcgtaca gcgcggcggc gaaggaaccg atgtcgcgca acgagtccgc
     4801 ggtcagcggg acggcggcgg cgagccgttc cagctcggag tcgatgacgg tcgaccacag
     4861 tccttgcttg ttgccgaagt aggcgtacaa ccgctccttg ttgacccccg cggtccgggc
     4921 tatccggtcc gtcgtggcac cggcgaaacc gtgttcggcg aactccacca cggcggcgtc
     4981 gcgcaaccgc cgcttggtct cctcggtgtc ccaggccatg gcggcaatct agtcgatccc
     5041 aaccgatcgg ttggacttcg gccgctcccg cacgtagctt gggacgggag tcgcgagatc
     5101 cgaagaccac tcatgtccag caggaggttc agatgcgcgc ggtcggcgtc acgaggttcg
     5161 gtgggccgga catgttgcgg gtgctggagg tcggggccga acccctcggc cgggccgatg
     5221 tgcgggtgcg cgtgacggcg gccgccgtga accccacgga cacgatgctc atcgccgggg
     5281 cccgcgccga cggcgaccgc ccggccggtg gtgtcgccgt gcccggcatg gacgtcgcgg
     5341 gcgtcatcac cgaggtcggc cccgacgtgc ccgcccggct gagtccgggc gcgcgcgtga
     5401 tggcgatcgt ggtcccgtcc ggcgaccacg gcggctaccg cgaggagctg gtgctgccgt
     5461 cggcgtcggt gacggccgtg ccgttggggt gcaccgacgc cgaggcgtcg acgctgccga
     5521 tgaacggcct gaccgcgcgc ctcgccctgg acctcatgcg gttgcgccgc ggcgggacca
     5581 tcgcggtgac cggtgcggcc ggagccttcg gcgggtacct cgtccagctg gccaggcacg
     5641 agggcctgac cgtggtcgcc gacgccgcac ccgcggaccg cgcgatggtg gccgccttgg
     5701 gcgccgacgt cgtcgtcgac cgggggccgg acgtcgcggc gcggatccgc gaccacttcc
     5761 cggacggggt cgacgggctc gcggacggcg cggtccaggg cgacgaagtg ctctccgcgg
     5821 tgcgcgacgg cggcgtgttc gccaccgtcc gcggctaccg gggcgacggc gcgcggggca
     5881 tcagggtcgc cgtggtgggc gtgcgcgact acgccgcgaa ctgggagaag ctggacggtc
     5941 tgcgcgagct ggccggacag ggcgcgctca caccgcgcgt ggcgggcacg ctgccgctcg
     6001 accaggccgc ggaggcccac cgcaggctgg ccgcgggcgg cacgcgcgga cgactggtcc
     6061 tcctgccgga gtagaccgcc gctgtccgat gtggacgatc ggacagcgcg gaccggtccg
     6121 aggcacgccg gaagggtggc ccacccggga ggaggtggac caccctggac caggggtcgg
     6181 tcagaacgcg atggcgttgt cgctcaggac gtcgccgacg tcgaggtggc cgaggtccgc
     6241 gacgtggctg atgtcgccga tgccggacac gccgccgagc gcggaggtca cgtcgccgac
     6301 gtggccgacg ccgccgagca cgtcaccggc ctgcgcgatg tcgccgaggt gcagggcgtt
     6361 gtcggtgacg gtgccggtga ggccggacag gtcgccgccg aggacgtcgc cggtgccgag
     6421 accggtggtg atgtcctgga cggtcccggt gacgtgggtg gtgtcgagga cgtcggcccc
     6481 ggaggagagg tcgccgacga ggtcggtcac ctggctctgc gcggtgatgt cgtgcacgac
     6541 ctcggtgacc ttggcgtgcg cggtgaggtc gttcacgctg tccagcgagc cgccgaggac
     6601 gtcggcgtcg aggccgtcgc ccaggtccgt cacggcggag aactggctgg tcagctgctg
     6661 cgcggtggcc gtgacaccgg tgagggcgct ggtgtccggc aggccgaggg cgccgctgtc
     6721 gaggacgtcg agggcgttgt ccgaggacag cgacccgaac acgccgccga gtccctgaac
     6781 gggggagtgg tccaggacga gcgggaggat ctcctgcacg tccagcgcgg agacgtcgcc
     6841 cagtccggcg gtctggagga cgccctcggg gtcggcctgg aacgccgaga gtgcctgcga
     6901 gtcgttcagc aggtgggagg cgaagtcctg cagcgtctcg aacgtgacca tctggatgag
     6961 ctcctgagag gggggaatcg ggtgtggctg acaaggagca acactaggga cgtcgtcact
     7021 gtccgcacat cgggtgacac acctagttcc gaacgtggta gcccgttagg gggaatgcgg
     7081 acatcgacct agggggacgg gggtgtccga ccattccccc taacgggtta accatcagtc
     7141 gtacggggaa gtcgggtgga gatccactcg accgcctggt cagcgggtgg gaccggggtg
     7201 tcggacgtgt gcgggccggt gcgctcggcc gcgaacgcgt cgggaagtcc ctggtgcgct
     7261 cccgtcaaga agccccaggc gcgttccgtg tcggagtccg atgtggacgg tcccggtcca
     7321 gcggggcgac gccgggcgcg ccgtcctcct ggccgatctc cggcacccgg cgcacggcca
     7381 gcgcgcccgc gatcccgagc agcgcgagga aaccgaagaa cgcggtgtac ccgccgaggc
     7441 ccagcagcag cggcgcggac agcgggacca gggactgcgg cagcatgttc gcgatgttga
     7501 cgatgcccag gtccttgccc gcgttcgcgc cgtcgggcag cacccgcacg cacatcgcca
     7561 tgtccacggc caggaacgtg cccatcccga cccccatgac gcccgccgcg acgaacacga
     7621 cggaggtcga cggcgcgaac gccagcagcg ccatcgcgac cacgccgatc aacgccgaca
     7681 ccaccacgaa cggcttctgc cgccgcagca cgtccgagag gtgccccgcg ccgaggctcg
     7741 cgatgatcgc ggtgggcacg aggatcgccg accacgtcag caccagcccg ccgacgtcgg
     7801 cctggctcac gccgaaccgc tggatcaggt agagcgagac gtagctgccc gccgcgtagg
     7861 tggcggtgat gaggaaccgc accagccacg cccagccgaa ggccgggtgg cggcgcgggt
     7921 cgagccagaa cgtccgcagc accacgccga tcccgccgtg cccgtcccgg cgcgggcgcg
     7981 gcctgccctc gcggatcagc agcaccgaca ccacacccgc cacggccgcg atcgcggcga
     8041 ccacccgcca ctgcagcgcc gacccggcgg gcagcgcggt gacgatcgcc agccccagca
     8101 gcggggcgag cgggatcacc aggccgagga gcccggaggc gagaccgcgc cgccgcgggg
     8161 gcacctggtc ggcgagcacg gcggtcgtcg cggactgctg gaagctgaac agcgccttgg
     8221 caaggcacca cagcaggacc acctgccaca ccgccgacgt ctcgccgagc gcgaccaccg
     8281 cggccgcccc ggcgagcgcc ccgaagagga tccacgtccg gcggcggccc agcgggaacg
     8341 ccgccaggtc gctgatccgg cccgcgatcg gggtggacac cagcacgacg acggcggcga
     8401 ggccggtgac caggccgaag gagtccgtcg ccgccccggt gtcggaggtc agggcggtca
     8461 gccgcagcgc cagcagcagc tgcaacgggg tgatgatcgc gatgtacacc ccgaactgag
     8521 aggtcagcag cgcggcggcg agtcggccga acccggtggt cccggtgccg ggggcgtcga
     8581 tgctcatccg gttctcctcc gcgcgtgcca gtcggtgtgc ggtcggcgac aaagggaggt
     8641 gacagcacgt caccagtcgg tgaatcttct tgggggaatc ggatatcggt caaccgctgt
     8701 aatggtgaat atcgattacc gtccggtcaa tggcgtaatt gagacagggg gcttgacgcc
     8761 gtgagcgcgt gatcgttagc gttccagtgg atttgatcgg cgcaagaagt ctgaccgaat
     8821 gtggttcgcc tcaccgggaa aggctggtct cgtggcccgg atcatccacc aattatccct
     8881 caacgagaat tgttcgccgc cgttgccggg tgtggtcgag gcgttgtcgg gcgcgctgga
     8941 ccaggtccac ctcaccctcg acgcgctggc cgacggcctc gcggccgacc tggccggacg
     9001 cctggggctc gacgcggggc gggtggtggc cggagccggg tccggggcgc tgctccagca
     9061 gttcctcacg gcgcacgccg gtgcggggac gacggtggtg cacacctggc cgtcgttcga
     9121 gatgtacccg ctgctgatcc gcaacgccct ggcggagccg gtcgcggtga ccggtcccga
     9181 cgaccggcag gacctggcgg ccgtggcggc cgcggtcacc ccggacacct cggtcgtgct
     9241 gctgtgcaac ccgaacaacc ccaccggtga ggtgctcgac gccgcccggc tccgcgacct
     9301 gctcgacgcc ctgccgccgc acgtgctcgt gctggtcgac gaggcctacc gggagttcgc
     9361 cgccccggac gcgatcgccg acgccgtgga gctgcacagg accgacgacc gggtggcggt
     9421 cgtccggacc ttctccaagt cccacgggct gctgggcctg cgcgtcggat acctggtggg
     9481 ggcggccgag gtcgtcgcgc cggtgcgccg caccacgccg ttctaccgcg tcccgaccat
     9541 cgcccaggcg gcggcggtgg ccgcgctcaa ggccgagccg gagatgcggg agcagtgcga
     9601 acgggtggcc gccgagcggg accgcgtccg gtccgggctg ctggacctgg gcttcgacgt
     9661 gccgcccagc ggcgggaact tcctgtggct gcggctcggt gcgcgcaacc gggagttcgt
     9721 ggagcacctg gccgaggacg gcatcgccgt ccgcgcactg gcgggcggct cgggggtgag
     9781 ggtcagcacc ggcatccccg aggccaacga cgcggtcctg cgcgcggcgg gccggttcgc
     9841 cgccggactc gccgcggccc gcacgacgcc cgcctcgacc gaccaccgct gaccggggca
     9901 ccgcgggccg ggtgccgcgc gtgcccggcc cgacggcgcc gacctcgtga tcccccactc
     9961 gtgacgagcc cccggtcccg gccgggtgag aggaacccga atgacttcgg tgcacgtcga
    10021 ccccgatccg ttcacggagg tcctcgaagc ggcgatcgcc gagggagccg aggtcctgtt
    10081 cggcgcccag cgcgacgacg gcgtgttcga ctacggcgag gacagcctga cctcgaccct
    10141 gggcacggtc ggcgcggtgt cggcgctgca cttcgccgac cccgtgggca gcgccgacct
    10201 gatcgccgcg ggcgccgggt ggctcaggcg cacccagaac gaggacggcg gctgggcgat
    10261 ggtccccggc ctgccgagcg aggcgggccc gacggcggtc gcctccgccg tcctgcacct
    10321 ggtcgacccg gagggcagcg cgaccccggt cgccaccggg cagcgctgga tggacgacca
    10381 cggcggcctg gacgcgatcc cgcaccccga ggtcgtctcg tggtgccgcc agtactacgg
    10441 cttcgtcggc tggctggccc cggaggacat gcgccgcttc ccgctggagc tggcgctgct
    10501 gcccggcctg taccgcaggc tgttcgacct gcgcctgccg atggcgtccg cgctcggcct
    10561 cgcccaggcc cggcacaagc cgctcacccg gctccagcgc gcgctggccc gctgggggga
    10621 gcccaacgcg ctgaaggtgg tccggcaggt ctacgagcac gagggctcga ccggggcctg
    10681 gtgcgagaac gcgtgggtca ccgggctggt ctgcaccggt ctggcccgcg cgggtctggc
    10741 gccggacatg gtcgccgccg ccgtcgggtg gttccaccgg tccatggcgc ccgacggctc
    10801 gtgggagacc ggcccgctcg acgcggcctg gacgatgtac gccgcgcgcg gcctcgccga
    10861 ggcgggctac gcgggcgacc cgcggctggc ggcctcggtc cggctgttcg tgcgcatcca
    10921 gcagcaccgc ccgttcctgg cgttcggctg cccgccgggc tactggggct ggtcgggcac
    10981 ggagggctgg ccctcgaccc tggagacggg agaggtcctc tccgtgctgt gcaggctgcc
    11041 cggcgacgag caggcggacg cggtccgccg gggggtcgac tggctcaccc gcgtgcagga
    11101 cacccgcggg tcctggggcc tctgcgtgcg caacaccaag gtggccaaca gcggtccgtg
    11161 cccgatgacc accgtgcagg ccgtcgacgc cctgctcgac gcgggtgtgc ccgccggcga
    11221 ccgccgggtg cgccgcgcac tgggctggct ggcgcgggtc cagagcccgg agggcacctt
    11281 cgagtcggtc tggtaccggc accacaccat gggcaccgcg gccgtgctgg agaccttctc
    11341 cagggtcggg cgcgcggccg acgagcccgc ccgccgggcg gtggcctggc tggaacgcac
    11401 ccggctgccc gacgggtcgt ggggggacgg ttccggcgcg cccggcacgg tcgaggagac
    11461 cggctgggcg gtgtcctccc tgctggccgc gggcgcggac ccggccaccg tgcggtcggg
    11521 cgtggactgg ctgctggcgc gccgacggcc cggcggcggg tggccgtcgg agaacgtgca
    11581 cgagtacgtg cgcttcgtga gccggtacag caaccccgcg ttcgcccacg ggatggcgct
    11641 gcgcgcgctc ggccgctacc ggacggcgac ccggcgggac acgacttcgt gagccgccgg
    11701 tcccaccagc tgaccccagg aaccggagag gcccgatgac cggcacgacg cacgaggact
    11761 ccttcaccga ggactactgg cgcgacccgc acgagaccct cgccaggacg cgcgagacca
    11821 gccccgtccg cgaggtcgag ttcgagaccg ggccgacctg gctggtcacc cgctacgccg
    11881 acgtgcgcgc cgggctcacc gacgagcggc tggccaagga ctggcggtcg agcctcccgg
    11941 aggaggaacg ggcctccgcg ccaccggggc tgcccgcgcc gatgtcgcac atgctgacct
    12001 cgctcgaccc gccggagcac acccggctgc ggaacctggt cgtccaggcg ttcaccgcgc
    12061 gccggatcgc cgagctgcgc ccgcgggtcg aggccgtcgc cgccgagctg ctcgacgccc
    12121 tgcccgagca cgagccggtc gacctcgtgg cgcggtacgc gatcgtcctg ccgatggtgg
    12181 tgatctgcga gctgctcggc gttcccgaga tcgaccgcga ggagttcgcc cgcctctcga
    12241 ccgtcctcat cgacgagtgc cccgaacccg agatggtcct ggcctccacc cggatggccg
    12301 actacctgga gggcctggtc gccgccaagc gcgcggcacc ggacagcgcg ctgctgtccg
    12361 cgctgatcac ggcgtcggac gagggcgacc ggctctccga cctggagatc gtggcgatgg
    12421 cgatgctgct gctcatggcg ggccacgaga ccaccgccgt gttcatcacc aacagcgtcc
    12481 gcgcgctgct ggccgacccg gccgggctgg accgcctcgc ctccccggcg tccgccccgt
    12541 ccctggtcga ggagctgctg cgctggctct cgcccgccat caacgcctcg ctgcgcttcg
    12601 ccacggagga cctggagatc ggcggggtgg cgatccgcag gggcgagtcg gtgatgctgt
    12661 cgaccggcgg cgccaaccgc gaccccgccc agttcccgga accgacgagg ttcgacccgg
    12721 accgcgacac cgccggccac ctggccttcg gccacgggat ccaccgctgc ctgggggcgg
    12781 ccctggtccg gctggagggc gaggtgggcc tgtccgccct gttcagccgg ttcccgctca
    12841 tgcgggcggc cgccgacccc gcggacctga ccttccgccg cagcgtccac gtccacgccc
    12901 cgcgcacgtt cccggtcgtg ctcggtccca ggaccgaacc gggcgagtga cgcgccgccg
    12961 gtcgcggtcg tcccgacggc cgcgaccggc ctggactcgc cgggggagcg gacctcggcc
    13021 cgcgcccccg cagcctcact ccttcacggt cgtcgccgac atcccggcct cctggaacct
    13081 gccccaccgc ggctccgccc cgcgcggctc gtcacccatc acggtgaccc gctgccccac
    13141 ccggcgcccc gcgtagtcgt tcaccgcgta gtgctgggtc gccctgttgt cccacatcgc
    13201 caccgcgccc tccacccacc ggtaccggca ggtgcgctgc gggctctccg acaccgcgaa
    13261 caggtgctcc agcagcgcgt cgctctcacc cttgctgagc tggaggatcc gccgggtgaa
    13321 catgcggttg acgtagaggc tccggcggcc ggtgaccggg tgcgtccgga ccaccgggtg
    13381 ctcggcctcg ctgcggaacg tgccgttcgg gtggacgaac aggtgcgacg ccgtggtgcc
    13441 ctccaacagg tcccggatcg gttccgacaa cgcctcgtag gcgaggtact ggttgctcca
    13501 catcgtgtcg ccgcccgatt ccggcgtcag cgtgatctgc aggacggagg cgatgggcgg
    13561 gctttgggcg aacgtcacgt cggtgtgcca gacatcggcg cgcgcgcctt gttcggaatc
    13621 gagcacgacg attttgtcgt ggccttccag tttcggcagg aaggggtgca cctccaactg
    13681 cccgaaccgg ctgccgaacg cctcgtgggc ctgcggggtc aggccgcccg cgtccgggaa
    13741 gaagagcacg agatggcgca tgagcaggtc gtggacctcc ttgaactgct cgtcgtcgac
    13801 cgagccgagg tcgacgccgt acacctcggc gccgagggaa ccggagatcg ggcgaacctg
    13861 gaatggcatg tcgtacgcct ttcttctgat gtgcgcgatc gaattccgtg cgcgtgtccg
    13921 gcggcacggt cgacagggat ttcggaatgc tcgtcgtttc tcttgaccgc cttcgcgcga
    13981 cgatgtcagg atcttggtgg acgaatcgtc tcccgcccta tcgaggggaa ttcatcggaa
    14041 tgaccgcaca ggacgagttg gcgaagatgg tcgacctcgc gacgccgttc gcggtcaggg
    14101 tggccgtcac cctgcacctg cccgagctga tcgacggcgg caccaccggg ctcgccgagc
    14161 tggccgcctc cgccggggcc gtccccgacg cgttgcgcag gctgctggac cacctcacct
    14221 ccatcggctt cttcgcccgg ccgcggcccg gcgtctacgc gttgaccgac gtgtcgcgcc
    14281 tgctgctgag cgaggactac ggcgcggcgc gcagctggct cgacagcgag gggccgggcg
    14341 cgaggatgga cctcgccttc gcgggcatgg cgcactcggt gcgcaccggc aagtccgcct
    14401 acggggtcgt gcacggcgtc ccgttctggg acgactacgg cgccgacgag gagctgcggg
    14461 tcttcttcgg cgggatcatg gccgtccacg cctggcagac cggcccggtc gtggccaccg
    14521 aggtcgactg gacgtccagc cgtcgggtgc tggacgtcgg gggcggtgtc ggcgcgctgc
    14581 tggccgaggt gctcaaggcc aaccggcacc tgaccggcgc cgtcctggac ctgcccccgg
    14641 tcgagccgga cgccaccacc gcgctgaagg aggccggggt gtccgaccgg gcgggcttcg
    14701 tgcccggcag cttcttcgac ccgctgccca ccggctacga cacctacgtg atctccaggg
    14761 tcgtcaccga ctgggacgac gaggacgcgc tgcggatcat gacccgcgcc gccgaggccg
    14821 tcggcaccgg ccgggtgctg gtcgtggagg tgctggccgg gcaggagcac gcgaagaaca
    14881 actcgtcgtt cgacctccag tcgctcgccc tgctcggcgg ccgggagcgc tcggaggagg
    14941 acttcgtcgc actcgccggg cgcgccgggt tcgccaccgc caccgcccgc cgctgggaca
    15001 gcgggctgct cgtcgtggag tgcgggctct gaaccaggac gtcgacgggg gtggtcggcc
    15061 gggtgggtcc gtccggtcga ccaccccgcg gcggcttcgt ggcacgggtg ccgcaccggc
    15121 acgggatccc ggcgcgccgt caccgcgacc gcgcccaacc cggcagccgc ccgcccctcg
    15181 ggtcgggcag cacgcccagc tggtgcagcc ggtccaacgg ggtgaggggg tgctgcccca
    15241 gccccgccat gttgtgcatg atcgtgtagc gcagccgccg gttgccgccg gtcttgcgca
    15301 gcgcgcggcg gcccagcacc cgcacgagcg gcgacaggtc gctgatcatg cgggtggcgt
    15361 tgtggctggt cgtcccgacg tgcgccagcg cctgcctgcg ctcggcgctc cactcgcgca
    15421 gccgcggccg cagcaggtcc ggtgacaggt cgccgtcgag cgggcgcaac cgcgtcgcca
    15481 ggctcgccgc gtccaggatc gagctgttca tgccctgacc cgccgccggg tgcacggcgt
    15541 gcgcgctctc cccgatcagc accagcccgt cggcggtcag cgacgtggcc agcgcccgcc
    15601 ccaccggcag cacctgccgg gtcggccagg cgcgggcgac gtcctcgcgc agcggggcga
    15661 acgccgggac gtcgcgcacc aggccgtcga cccacccggc cgcggcggtc gcgtccacgc
    15721 cccggagctc gtccggtccg acctgcacgt acagccgtgc ccgcccgccg ggcagtgggt
    15781 agcgcatcgc caggccgcgc ggggtcgcgt aggtggatac gtcgtcgccc ggcgcctggc
    15841 cggtcagctc gaacgccgcc agccggtgct cgtagtcggt gcgcacgacc tcgatcccgg
    15901 aggcgcggcg caaccgcgag gacaccccgt cggccgccac gaccagcgcc gccgtcaggt
    15961 cgccgccatc ggtgcgcacg cccgtcgtgc ggccgttctc gtcgcgcagc agctcgcgca
    16021 ccagcacccc gcgccgcagc tcgaccccgg cgggcagcgt gcggctcagc gcgcccagga
    16081 tcacgtggta gtcgtgcacg agcagccacg gccgctcggt gggcagcgtc cggtagtcca
    16141 tcgtcatcag cgccgcgccg tgcgggtcgc gcgccaccag gcccgacagg cgcagcgcgc
    16201 cgtctgcgtc cagctcgtcg acgacacccc agtgcgcgag cacgcccgcc gcgccgggtt
    16261 gcagcagctc gcccttcggc acggccctga ccgcgcgctg cttgtccagc accagcacgc
    16321 gcaggccgag cccgcccagc gcgtgcgccg ccgcgagccc ggcgaccccg gccccgcaca
    16381 ccaccacgtc cacgtcggta ctcatgccca gccccgtccc cggtcgtcgt agtacctcac
    16441 gcgtgtcatg aggcggtcgc cctccgcagg cccgccgggg ggatctcgtg ccgggcgcgc
    16501 atcgcgtgct gggtgacgac gctgaacgcg acgaccggca gcagcaccgc caccgcgacc
    16561 ggcgcgcccg caccggcggc cgtcaccgcg cacgccagca cgagccgttc ggccaccagg
    16621 acctcgtggg cgcgcagcgc cgactcgcgg gtgatgccgt cgccctgggt cagcagcccg
    16681 ccgaacaccc acgcgccgat cgcggtggcc accaccagca gcgtcaggta ggacgtgcgg
    16741 tcgggcagcg gcaccagcac ggacgccacg gcggcgacca gcgccgagcc gtagagggcc
    16801 tgcgccaggc gcgcgccgta ggcgacaccc cgttgcaccg gcaccgaccg gtacccgccc
    16861 gcctcgtcgc cctccacgtc ccgcaccgcg ccgaccaggt tggacgcggc gtcgtgcagc
    16921 aggaacacca cggcgaacgg caccgccgtc cacacgcggc cgtcgggcac gcaggtggcg
    16981 cccgcgagca cggccagcga ggtcagcgcc ccgcgcacca ggttgccgga gatgccgcgc
    17041 cccttgcaca ggcggctgta ggcggcgatc ccggccacgc cgaccaccag cagcaccagc
    17101 acccgccagc ccgcgaccgc cgccgctgcc gccgcgacga cctcgcacac caccgccgag
    17161 agcagcgcgg cgcgcgggcc gagccgcccc gaggggatgg ggcgctgggg tttgtcgatc
    17221 gcgtccaggt cgcggtcgag ccagtcgccc aggtagtgcc ctcccagcca gaccagcacg
    17281 gggatcagga cggccgcgac caggtgccgc ggctcggggt ggccgcccgc gacggacgcg
    17341 cccgccagcc cgacgacacc ggggtagggc agcgtgtacg ggcgccacgt ctggacgtgt
    17401 gcttcgacgg tgcgccgcca ggtcgccacg gctaccgcct ccggtcgacc gacatgtccg
    17461 cgacctcggc gagcatcgcg gtgtgctcgt tggcgggcag gtcggcgagg taggacttcg
    17521 cgagcgcgac ctcggcctcg gcgtgctcca ccgcgcgctt gagcgcgccc gtctcgtcga
    17581 gcacgtcccg cagcgccgtg aacgcctcct ccggcgtcag ctcaccgctg agcgcgccca
    17641 ccacccgtgc gcgctgctcc ggcgtgccgg tctcgtgggc gagcagcacc gggtaggtgg
    17701 ggcgcaggtt gcgcaggtcg ctcagcccgg acttgccggt gacggcgggg tcggacaggt
    17761 agggcagcag gtcgtcgtgc atctggaacg cgagaccgag gtgctcggcg tactggccca
    17821 ccgcgtcgac cacggcgggc tccgcgccgc cgagcaccgc gcccgcccgg cacgcgccgc
    17881 ggaacagcgc ccccgtcttg agcgccatca ccgtcacgta ctccgccagc gggcgcgagg
    17941 ggtcggtggc catcgcgccc tccagcgcct ggccgcggca cacgtccacc gcggcgtcgg
    18001 agatcgcgcg caccgcccgc agcgcggccg cctccggcac accccggtcg acgcaggtcg
    18061 tcaccgagcc gaacgtgcgc atcatcagcg cgtcgccggt gacgatggcg tcgggcacgc
    18121 cgaagcggtg ctgcaccgac ggcctgcccc ggcgcgtctc gtcgccgtcg atcacgtcgt
    18181 cgtgcaccag cgacccgacg tgcaggtact ccaccgcgag cgcggcgggc acgacctgct
    18241 ccacgtcccc gccgaccgcg cccgccgcgg cggtgagcag cagggggcgc agcagcttgc
    18301 ccggtatgag cagcgcgtag cgggagatgg cgagcaccgg gtcgtcctgc tccggccact
    18361 cgccgtgcag cgcctcgcgc agccgggaca cgaccgcctc ggcggcgggg gagaagccct
    18421 tgcgggtgta ctcgccgacc agcgcgatca ccgcgtcgtt ggcctcgcgc gtccccacgg
    18481 tcacccggac gcccaaccct cccacgtcgc cgaccgccac cccgtgctcg gcgaggaact
    18541 cgaccagtgg cggtccctcc gcccccagcg ggagccacag gtagttgccc gcgctcggcg
    18601 gcaccggcag gccgtggtcc agcagcgcgg tccgcagccg gtcgcgctcg acgcgcaccg
    18661 cggcgcactg cgcgcgcatc cggtcctccg cggccagcgc ggcgatggcg gcggcctggg
    18721 cgaccgtgct gacccggaag aagggcgcgg tgccgcgcag cggcgtgacg acccgctccg
    18781 ccgccaccag gtagcccacc cgcaggccca gcaggccgtg cgacttggag aacgtcctga
    18841 ccaccacgac gcgggggtcc tcgcggtgca gggccagcgc gtcggcgatc tcggcggggt
    18901 cggagaactc gcggtacgcc tcgtccacga ccagcagcac gtccggtggc agggcgtcca
    18961 gcagccgccg cacctcggcg tggcccagca ccgaccccgt ggggttgttc gggttgcaca
    19021 gcaggacggc cctggtcctg ggcgtcaccg cggcggccgt cgcgtcgacg tccgtgccgt
    19081 acccgtcggc cagcggcagc acgaccggcg tggcaccggt gttgcgcacg agcggcccgt
    19141 acccccagaa cgacggcgag gcgtgcacga cctcgtcgcc gggcccggcc gtaccgtcga
    19201 gcagctgctg gagcaccgcg ccggagcccg ccccgaccag cacctcggag gcgggcacgc
    19261 cgaggtgggc cgcgatggcg gcggtgagcc cgtcggacat cgcgtccagg gtcaagtggg
    19321 agttgtcggc ggctgctatt accgcttctc ggactccggg cagcggaggg gcgaagttct
    19381 cattgaggga aagctggtgg acgatgttcg gcacgctgag gtccccgttc accggtcgag
    19441 ccgtcaggaa aacatcgaag gcgttccgaa caacctctac cgaattgacg gcttcctggg
    19501 aagggggatg acgcattgtg gagaacgcgc taaagggcga ccggatggac gcggatgtcg
    19561 atagctccgg ttaacacacc gtcaactcgg cgaatcttat ccgcgacaga attcgtgcta
    19621 aggcggtcgg cagccgctgg gtcgtccgga gcagcgctcg gctgatcggt tcgcggctgt
    19681 tcgtgtgacg ccgtcgcgcg gccggaccgg tgcgcggacc ggaggtgccg gcggtacggc
    19741 cccttcgtgc cgcgagtccg gcgagaacat gacaatcccg aacgggggcg atacccgaat
    19801 gggctaggag ggtgtctcac gtggcaggtc gcggcccctc cgcggcgtcg ctcgcgccga
    19861 ctgtccgatg tggactcaag tgccgggatg gccggcggtg tgggcgacct ggtcgttttt
    19921 cgtccacatc ggacggtcga tgcgatggtg ggacgagccg gtcgggcggc ctccgatcag
    19981 tgcgacccgc cgacgccgac cgtgcccgcg aggatgaggc ccgcggcgat gagcagggcg
    20041 tgcggcacga ccacgcccgc ggtgaagaac gccgcggcga cggccaggag cacccacttc
    20101 acccggcggg agaggcggaa cggacggggc ggctcgacgt gggccgtccg ccggtgccgg
    20161 tcgatcccgg ccacgggcct gcgtcgggtg gggcggggcg cgggggtgcg cggcgcgcgt
    20221 cggacgaggg gctgctcctc ggttcggacc acggtctcct cctggcgggt tcggcggggg
    20281 cggggtcttc gcctccactg tccctgtgcc cgcgccgcgg cgcgatcggg tcgcgggccc
    20341 attccaggcc ggtcctgacc gccatcgccg ctgtggcggg atcgggggag aggacccaac
    20401 atgggtgttg ccacggatgg acaggcaccc ggttctccgg tcaccctcgc aggcgtgtcg
    20461 ggtcgtgatc accaggaggc agcgcgcgtg tccttgttcg gcaggatctt cctgctcaac
    20521 gccgtggcga tggtcgcggc cgtcgcgctg ctcgtgctgg ggccgatcac ggtgtccacg
    20581 cccgcgctgc tcgccgagat cctcatcctc gtcgcggggc tggccgtcct gctggtcgcg
    20641 aacgccgcgc tgatccggct ggggctggcg ccgctggaac ggctcaccag ggcgatgacc
    20701 acgatcgacc tgctcaaacc ggggccgagg ctgaccgcgt cggggcacgg cgagatcgcc
    20761 gacctgatca cgacgttcaa cgggatgctc gaccggctgg aggccgagcg cgggtccagc
    20821 tcggcccggg cgctgtccgc gcaggaggcc gagcgccgcc gggtcgccca ggagttgcac
    20881 gacgaggtcg gccagtccct gaccgccgtg ctgctggacc tcaagcgggt cgccgaccgc
    20941 gcgcccgcgc ccacgggcga cgagctgcgg caggtccagg agaccgtccg cagcacgctg
    21001 gacgaggtgc gccggatcgc ccgccggctg cggccggggg tgctggagga gctggggctg
    21061 gtcagcgcgc tcacggcgtt ggcggcggag atctccgagc acaccgacgt cgcggtgcgg
    21121 cgcacgttcg accggcacct gccggatctg gacgaggaga ccgagctcgt cgtgtaccgg
    21181 gtggcgcagg aagggctgac caacaccgtc cggcacgccg gcgcgcggcg ggtcgagctg
    21241 ctgctgcgct cgacgtcggc cggggtcgag ctgtgcgtcc gcgacgacgg cgaaggcctg
    21301 ggcgactccg tcgagggcgc cggcatccgg ggcatgcggg aacgcgcgct gctggtcggc
    21361 gcggatctgg ccgtcggacc cgccccgcgg cggggcaccg aggtccggct cgtggtccgg
    21421 acgtccgggc gagcctcgtg acgcccggca ccaggccggt gcggatcctg ctcgcggacg
    21481 accacgcgct ggtgcgccgc ggcgtccggc tgatcctcga caacgagccg gacctgaccg
    21541 tggtggggga ggcgggcgac ggggcggagg cgatcgccat ggcccgcgcg gacctgcccg
    21601 acctggccat cctggacatc gcgatgccga ggctgaccgg cctgcaggcc gcgcgcgagc
    21661 tgtcgcggct gctgccggac ctgcgcatcc tcatcctcac gatgtacgac aacgagcagt
    21721 acttcttcga ggcgctcaag tccggcgcct ccgggtacgt gctcaagtcg gtcgccgacc
    21781 gggacctggt cgaggcctgc cgggccgcga tgcgcggcga gcccttcctg taccccggcg
    21841 cggtcgcctc gctcatccgc aactacctcg accgggtgca cgacggcgag agcgtccccg
    21901 cgaaggcgat caccgaccgc gaggaggaga tcctcaagct cgtggccgag ggcaactcct
    21961 ccaaggagat cgccgacctg ctcttcatca gcgtgaagac ggtcgagcgg caccgcgcca
    22021 acctgttgca gaagctcgga ctgaaggacc gcctcgccct cacccggtac gcgatccgcg
    22081 ccggcctcat cgaaccctga acacacccgc gagaagaggg aagaccgcct gtggacgtcg
    22141 aagtcacgcc cctgcccgga atcggcgtcc gcgaggactt cgccacccgc gcgggccgtc
    22201 ggatcggggt ggtctcccac cgcgacggca agttcgagct catcgttgcc aggcaggacg
    22261 accccgacgc cgcggtcgcc tcgataccgc tcaccccgga ggaggcggtc accctcgcgg
    22321 gcctgctcgg ttccccgcag ctggtgagca ggctcagcga gcagcaccgc gacatcagcg
    22381 gcatcaccac ccgccagctg ccggtcgtcg cgtacgcgaa ccggacgctg ggcgacaccg
    22441 cgctgcgcac ccgcaccagc gcctcggtcg tcgcggtggt ccgcgccggt gtcgcgcacc
    22501 cctcgccggg gccggagttc ctgttccaca ccggcgacct cgccgtcgtg gtcggtaccg
    22561 ccgaagggct caccgccgcg gccgacatcc tgacaggcgg ctgagcgcgt gcaggagacc
    22621 gccatcgccc tgatccagct cggcgccgtc ttcttcggtc tcggcctgct cggccgggtc
    22681 gcctggaagt tcggcatctc gcccatcccg ctctacctcg tcggcggcct cgcgttcggc
    22741 tccggcgggc tgatcccgtt gcacggcatc gacgagttca cccacctggc cagcgagatc
    22801 ggcgtggtgc tgctgctgtt gctgctgggc ctggagtact cggcctcgga gctcacgacc
    22861 gggctgcgca agtcgtggac ggccggactg gtcgacatcg ccctcaacgc cgtgccgggc
    22921 gccgcggccg cgctcctgct cggctggggt ccggtcggcg cgctcgcgat ggcgggcgtc
    22981 acctacatct cgtcctcggg gatcatcgcc aaggtcctcg gcgacctcgg ccgcctcggc
    23041 aaccgggaga cgccggtcgt gctgtcggtg ctggtgttcg aggacctggc gatggcggtg
    23101 tacctgccgg tgctgaccgc cgtgctggcg ggcgcgagcc tgctgggcgg cctgacctcg
    23161 gtgggcatct cgctgctcgc cgtcacggtc gtgctcgtgg tcgcgctgag gtacgggcgg
    23221 ttcatctccg ccgtcgtgga cagcccggac cacgaggtgt tcctgctcaa ggtgctcggc
    23281 tcggcgctgc tggtggcggg catcgcctcg cagctgcagg tgtccgccgc ggtgggcgcg
    23341 ttcctgctgg gcatcgcgat ctccgggtcc accgcggaga acgcgaccag gatgctcgaa
    23401 ccgctgcgcg acctgttcgc ggcgatgttc ttcgtggtgt tcggcctgaa caccaacccc
    23461 tcctccatcc cgcccgtcct cggcgtggcg gcggcgctcg ccctggtcac caccgccacg
    23521 aagatcgcca ccggctggtg ggcggccaag cggcagggca tcgcggcgat ggggcgggcc
    23581 cgcacgggcg cggcgctggt ggcgcgcggc gagttctcca tcgtgatcgc cgggctcgcg
    23641 gtcgcgtccg ggcacgtgca ggacgagctc gccgcgctgg ccaccgccta cgtgctgctg
    23701 atggcgatca tcgggccgat cgtggcgcgg tacgtggaac cggtcagcgg gttcctgctg
    23761 cgcgaccggt cgaagagcgg cgcgcacggc tgaccgaccc ggccaccggc ggtgcgacca
    23821 cccgcaggag tgcccgcgcc acctcgcccg cgtcgggccc ggcggccagg acgtagtggt
    23881 cggggcgcac ggcgaccgcg gtggcgccga gccggtcgaa ccagcggtgc agggtgccgt
    23941 ccaggtcggc cacgacgccg tccccggcgg acttcccgat cccggtcgtc gtgacgcccg
    24001 ccgcgcgcag ggccgtgacg tcgacgtctg ggaagtcgtc cccgagcagc agcaggcgga
    24061 agccgccgcc gacgacctgg tcgagcagcc cggcccgacg gccgtcgtcg accctgccct
    24121 gcaccgagag cgcgccgccg ccggggccgt gcaggccggg accgaggtcg ggcaggcgga
    24181 tgcgttcggg ctcccggagg gagtcgcggg tggcgcgcat cgcgtcgtcg cgctcgcggg
    24241 cgagcgcgtg gtcggtcagg gtgtgccggc gtccgagcgc gatgctggtc gcggtcaggg
    24301 cgcgcacgtg cggctcgcgc tcgctctggt aggtgtcgag caccccgggg tcctgcgcgc
    24361 cggtcgacac caggtccagc ttgaacgcga ggttggccgc gtcgcgcatc cccgagcaca
    24421 tgccctgccc gaggaacggc ggcatccggt gggcggcgtc gcccgcgagc aggacgcgcc
    24481 cgtcgcgcca gcgccgcgcg accagggagc ggaacgtgta ggtcgcgacc cgctcgacgt
    24541 cggcgtcggc cggggtgagg tggcgctcca cccgccgcca cacctccgcg tcggcgatct
    24601 cgcgccccac gtcggcgtcg tcgagcatga agcagaaccg ctggcgcccg gcaccggtgg
    24661 tgaagatcgt ggtgggcccg tccggatcgc cgacctgcaa ggccgagggc aggcccagct
    24721 cggcggcggg acggcggagc acgaagtcgc acaccagcca cggttcggcg aagccgaggt
    24781 cgtcctcgtc gatgccgagc gccgtgcgca cgaagctgtt gccgccgtcg cagcccacga
    24841 cgtagcgcgc ccgcaccgtg ccgccctcgg ccgtgacgag ccggacctcg tcctcggcgc
    24901 ggtcgaggcc ggtcaccgcc gcgccgagcc ggacctcgac cgagggcagc gacccgcacc
    24961 gcgcgtgcag cgcccgctcc aggacgggct ggtggaacat gagcaggtcg ggccatccgc
    25021 tgtcgccgac gagcctgctc tccaggctga gcaggacctc cccggcggcg tcgctccact
    25081 ggtaggcctc ctgcacgtgc agggtgggca ggagctcctc ggccaggccg agcccggcga
    25141 gcagccggag gacctcgccg tcgaagctgg ccgcacgggg caggccgtag agcgcgggat
    25201 ggcgttccag cacgaccacc gagcgacccg cctgccccag cagcgccgcc agtgtcagac
    25261 ccaccggccc cgcgcccacc accgccacgt ccacgacgtc gtcggtcatc gtcctgccgt
    25321 cctcacgtgc ggtcggtgcg ccggtcaggg gatgagcacg agcttgccgg gagcgtgccc
    25381 ggcgagcccg acctcgtgcg ccttcgccgc ctcgtcgagc gggaaggtgg tggcgacgac
    25441 gacgcgcagc gcaccggacc cggcctgctc gacgagctga ccgcgggcgg ccgtgcggac
    25501 ctcggtgccc gcgtcctgcc cagggccgta gccgagcacc gcgatgcccg ccgcggcccg
    25561 gcgcggcgac ccggcgatcg aggcgatccg ggtgcggtcg gccaccagct ccagcgacac
    25621 gtcgagcgcc tcgtcggtac cggcgaagtc gaccgcggcg tcgacgcccc gcggcgcgac
    25681 ggcgcgcacc cggtcggcga gccccgcgcc gtagacgacg gggacggcgc cgagctcgcg
    25741 cagcagcgcg tggttgcgct cggcggcggt ggcgatcacc gtcgcccccg cggcggcggc
    25801 cagctgcacg cccatcaggc cgacccctcc ggacccgccg tggacgagca ccgtgtcacc
    25861 ggcacccacc ccggcggcgt gcagcgcgtg gaccgccgtc gtgccggtca gcatcaacga
    25921 cccggcctcg gcccagccga gcccggcggg cttggggagg acggaggtgg ccggggccgt
    25981 gacgcggtcg gcgtaggcgg cggtcaccgg gtacacgatc acctcgtcgc cgacccgcac
    26041 accggtcacg tcccggccga cctcggtgac gacgcccgcg cactccagac cgaccgaggg
    26101 catcgaggcg gcgatcccgg cggcgtcctt gaggtcctcg gccacggcgt ggaaggtccc
    26161 gctgtagagc ttccagtcga ccgggttcac gcccgcggcc cggacctcga cgaccacgcc
    26221 gtcggcggcc gcccgcgggg tgggcacctc ggtcacggcg agcacgtcgg gcgagccgta
    26281 ggcggtcggg cgcacgatcc tgggcatgcc tgttctcctg tcctgctgac tggcggccct
    26341 gccccgatgg ggcggccggt cgggtgtctc ctggtcgagg gcggaacgtc cgccgtcgag
    26401 gactcccgag aaccagtatc gagccgctcg ggcataattc ccagtgcatt gtcggtaggg
    26461 actacatgcg tcggacgcac gaatggggac ggtcgtggcg gaggacctgg acctcaacct
    26521 gctgcgcgtg ttcgacgcgc tgatggacac cggcagcgtc gccaaggccg ccgagcgcct
    26581 gcacctgtcg gccccggcga ccagtcgcgc gttggggcgg ctgcggcgcg cgctcaacga
    26641 cccgatcctg gtgcgggcgg gccgaggtct ggtccccacc ccgttcgccc tgcgttccac
    26701 cggcacggtc agggcgctgc tcgacgccgc ggaccgcctg cggaccggcc ccgccgacac
    26761 cgacccgcgc tcgtggcggc gcacgttctc gatccgcctc aacgacggcc tggtcccggt
    26821 cgtcgccccg cgcctcaccc gccggatcgc cgccgaggca ccggacgtcc gcctgcggtt
    26881 cgtcccccag gactccaagg accccgaccc gctgcgcgac ggctcgatcg acctcgacgt
    26941 cacggtcgcg ggcccaccac cgcccgacgt ccacacgtcg acgctgttca ccgaccactt
    27001 cgtcgccgtc gtcgcggccg actccgacct cggccgggcc ccgcggctca ccctcgacga
    27061 cctgtgccac cacccccacg tctccgcctc ccgccgcggc ctcgcccgcg gcccgctcga
    27121 cgacgccctg gaaccgctcg gtcggtcccg ccacgtctcg gccgtcgtgc ccacctacgc
    27181 cgtcggggcg ctcatggccc tggaacagga cctcatctgc ctggtcccgc acgtgaccgc
    27241 gacccacctg gtcgaccgcg gcgtccccct gcgcctccac gacgtacccg tcaccctgcc
    27301 gaccgccgac gtcgaactgc gctggcaccg ccgcgtcgac gacgaccccg cctcgcgctg
    27361 gctccgcacc cacctccacg acaccatccg cccactggcc gctgtgccga gggggtgagc
    27421 gggcgctcgg gctacggcgt cgcgggtcgg gccatccaga gccaagcccg gtcgcggaag
    27481 gtcttcacct cgacgtcgac ggggacgaac tcgtccgggt ccacgcccgg caccccttcg
    27541 gcgaccacgt aaccgtgcag ccggtccgac agcacgatcg ccaggtccac gtccgggtgg
    27601 tcgagcacgg cccggcgcag cggtgggctg tcgagcaggc gccccagact ggtcgcgacc
    27661 tttcctccga acccgagcgc ggccagaccg accggtccga cgtcgaccgc catgcgcagc
    27721 cgcacccggt cgcggtgcac ggtgttgtcg cgccccagcc gctccgcggc gccgcgcagc
    27781 agcctgggca acgcgcgctg gacgtccacc cgttcgggca ggaacaccat cagcccgtca
    27841 ccggtgccct ggtggtcggc ctcgggcagc cgcacgtcca ggtcgtccag cactccctcg
    27901 accagcgcga ccatccgccg ctgcaccagt tcctggtcgg gtgtggagcg gcggccgtag
    27961 tccacgacgt cgatcacgaa ccccgtccgc atccgcctgc cggtgggatg gcctgccgct
    28021 tccggtcggg tgctgagccc gcgcacctcg gcggcgagtg cgcgcccacg ggtcagcccg
    28081 agcagcgagt cgtccagcgt cgccaggaac cagtcggcca gtccgacgtc cgcgggaagc
    28141 aggtcgggtt ccagtgccgc catgttcgtc ctggtggtct ccaccgacgt gcgcatccgc
    28201 tccacccggt cgcccgcgac ccgcagtccg atctcgtcgc ggcgcagctc gtcgacggcg
    28261 gacgccgggt cgtcgcgcga ctcgacgaca tggccgtcga cctgttcgcg caggcccgcc
    28321 agccacggtt cgtcgcgtcg ccacacccgg acgtggtggc gcagcaagga cgcgtgcagc
    28381 aggtagcggc ccagcggtgg catctccgat ccgcccctgc tccacgtcca cgcggtcagc
    28441 tcgtcgtcct cgccctcggc cgcgatcacc acgaggtcgc gtgaccgccc cacgtcgtcc
    28501 acgggttccc acaccaggaa ccgcctccgc cgctgccagc gcacgacgtc gcgcaggcgt
    28561 tcgggcagcc aggcgcgcac gtcgtcggcg ggctgcttgg cctggtggac ccggacaacg
    28621 ccgagagcgg atcccgcgtc ggcccctact acctcgtcgc accaacgatc gaactcgatc
    28681 caccccggcg gggctgccgc gccgagcccc ggcgtgccgg gcacggcgaa gatcagcgac
    28741 agggcgagca cggcaccggc gcggcgcagg accacctgca cgtccaccgc gccgttctgg
    28801 gcggcggcca gcgcgccatc gggttcgccg cggacgtcgg ctggtggagt cgtcggcagg
    28861 ccgacccgcg gcaccggttc ggtggcgccc agcaggtcgc ggcaccgggc ccagatcgcc
    28921 ttgaccccgc cgatcgccgc gtccgcgtgc tcaccgcgcg acgggacgta gaggtggacg
    28981 accagttcct gctcagccgg tccgggggtg gtcatcgtcg ggcttgtcgc gcaggctgtc
    29041 gacgatctcg gcctgctgtt cgcgcaccgc gtcggtcggt ggcaccgtgg gctccttgcc
    29101 catccccggc cccatcagcg gcgagatcag ctccagctgg acggtcgcgg cggtgacgcc
    29161 agcgctgtcg ttcgcgcgca ccgcggccgc cagcgcggtc agccgcgccg acacctcggg
    29221 ccagcggtcg gacggcagct cccagcccag caggtcgtcg aggacgtcca aggcgtcgtt
    29281 cctggcttcc cgttccagca ctcgcgctgc tccctccgtc gcggccacca ccgtaagggg
    29341 ttgccactgg acgttcgcgc cacgtcgcac cggcggcggc ccgttccacc cgaatggcag
    29401 ctgatgccgg aacgccgcgc gccgataggc aggatgtgat cactgatgtg gacctgctgg
    29461 agcaccacgg cgggaggttg ctgtccgcgg ccctggattc cgcggaaccg gcgttc
//
