LOCUS       NZ_PVTF01000005        22524 bp    DNA     linear   CON 03-MAY-2024
DEFINITION  Umezawaea tangerina strain DSM 44720 Ga0180964_105, whole genome
            shotgun sequence.
ACCESSION   NZ_PVTF01000005
VERSION     NZ_PVTF01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Umezawaea tangerina
  ORGANISM  Umezawaea tangerina
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Umezawaea.
REFERENCE   1  (bases 1 to 671732)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase
            II (KMG-II): from individual species to whole genera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 671732)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.9.0
            Expected Final Version            :: No
            Genome Coverage                   :: 86.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003002815.1-RS_2024_05_03
            Annotation Date                   :: 05/03/2024 03:47:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,483
            CDSs (total)                      :: 9,418
            Genes (coding)                    :: 9,322
            CDSs (with protein)               :: 9,322
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 20 of 97
            Pseudo Genes (incomplete)         :: 83 of 97
            Pseudo Genes (internal stop)      :: 2 of 97
            Pseudo Genes (multiple problems)  :: 8 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:41:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 248379
            Orig. end                         :: 270903
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVTF01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22524
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="2"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22524
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22524
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12524](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12524
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(825..841)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    complement(1608..1622)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.82"
                     /tool="antismash"
     misc_feature    complement(1704..1718)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.62"
                     /tool="antismash"
     misc_feature    1712..1725
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.45"
                     /tool="antismash"
     misc_feature    complement(1731..1745)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.55"
                     /tool="antismash"
     gene            1746..4427
                     /locus_tag="CLV43_RS18645"
                     /old_locus_tag="CLV43_105219"
     CDS             1746..4427
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024306.4"
                     /locus_tag="CLV43_RS18645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105219"
                     /product="ferritin-like protein"
                     /protein_id="WP_106188483.1"
                     /transl_table=11
                     /translation="MPTVDNIELYHDPNNFEPRFQRPMVLPGQLNGMWNPLGTGSFRLV
                     GCTVTSLVRADGSTGADDPLIGGQVTEDDARVSAKLVDLDVNDQQVSMIFGLRVRLVDA
                     AGAELFRGDFEPAAFDDLWSRFDPGRPGDLSAAYQSVLTNVVWAEETTHAPLAELREAS
                     AAGLLSVKFTTDRAEIDPSSPRITYGRVIGAIGPAGPDEPRHFVASRRLRRQAGGTFNH
                     APCRVDTTSGVVSVDLANSLPVATSGGPVASVGPLHLAVLPPDGVPRRVAALGTVDEEF
                     LESRAGIADVRLTAEQVAAVVSTRIAVVDSAARPVVLLAENADATMLRADDPVFRLHPG
                     GAEATASTTLHATRLGSPAAGVEITLGGADETPGLDHPHLLTTDVRGRAEVTLVGGDPG
                     PPGPFGDGRTFSVPYGPVGSPVEGRLHVLVTELYQAPEHPTWVADVQPIFQRYANLYPA
                     MRKVLDLSNHHDVVRYRDAIKYALSLPVAHPNHMPVTRALSPAKRDMVLRWLDSGPVPA
                     VLRIDTPEALRSALQQALLVEQAVIPPYLCALFSLKPNRNVEVAEIIRGVVRQEMLHMA
                     LVGNLLNAVGGRPRIGRPGFVPVYPGRLPGPVLPDLEVRLRRCSVEHIRDVFLAIEQPE
                     HPIVDGRRFTGAVLDRSRIEVADTGELLAASEAELDGLAAWFDKAEYPTMTIGWFYNQL
                     ARAVIGLDRELAQQGGTLFAGDPARQVSWPGAPGTLFRVTDRHTALLAIHEIIEQGEGS
                     PHELDADTRPASGELGHYYRFKEIVEGRRLVRDHEGRWVYEGAPVRFDPDDVHPMVDDP
                     DASLLQDGSRAKAQADVVNATYTKMLTGLDRIFDGNPQELADVQGLMYSLEVEAGKLLE
                     LPSGLEPGTVAGPAFQSSAVPW"
     gene            4424..5158
                     /locus_tag="CLV43_RS18650"
                     /old_locus_tag="CLV43_105220"
     CDS             4424..5158
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="CLV43_RS18650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105220"
                     /product="sensor histidine kinase"
                     /protein_id="WP_146174801.1"
                     /transl_table=11
                     /translation="MTELRDGTRQLLVRLRALSNELAVLTGQARDLVVSRTGAGVLARE
                     RERLHRDMHDDLGPTLAGIRLRLDTASARLTDDPVARQLVLDAAAETARTMDEIRRTID
                     GLPPPDLAREGLSTALRMLAARTSHTSTAVAVTVPDHPPALSEATELAAYRIAAEALIN
                     VLRHADARHVDVGLFLRDDHVVLEVADDGAGPPPAGWWGDGTGLFSMRRRAEELGGSCV
                     VVLRMDGTAGTLVRAVLPRGPA"
     gene            5155..5817
                     /locus_tag="CLV43_RS18655"
                     /old_locus_tag="CLV43_105221"
     CDS             5155..5817
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103860.1"
                     /locus_tag="CLV43_RS18655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105221"
                     /product="response regulator transcription factor"
                     /protein_id="WP_106188485.1"
                     /transl_table=11
                     /translation="MTVQVLLVDDHPLFRSGVRTALQDAADLRIAGEAATGEQALGLLR
                     ESDPAVDVVLLDIRLPDHSGIDIARTIVGEPPNGRQAPRVLVVSATQDDALVVAALRAG
                     AHGYLVKGVSRDELLWAIRTVAAGGAVFGPAVASRLRDYFSAVHEVPSRAAFPELSDRE
                     LEVLDLIARGRSNRHIARQLVVAEKTVRNHITRVFRKLQVDHRDAAILRAKDAGLGV"
     gene            complement(5819..6493)
                     /locus_tag="CLV43_RS18660"
                     /old_locus_tag="CLV43_105222"
     CDS             complement(5819..6493)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680637.1"
                     /locus_tag="CLV43_RS18660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105222"
                     /product="response regulator transcription factor"
                     /protein_id="WP_106188486.1"
                     /transl_table=11
                     /translation="MSGPVRVLVADDQALLRGSFRVLIDTDPGLTVVGEARDGVEAVAL
                     ARSEKPDVVLMDVRMPVMDGIEATRRICGSPDTDDVRILILTMFNLDSYVFAALRAGAS
                     GFLLKDAPPETLLDAIRVVADGDGLLSPTLTRRLITEFASGQQPAPPRVGTLSGITGRE
                     REVLVLIARGMTNAEIAAHLHLSPATVKTHISHLLGKLEARDRAQLVIAAYETGLVSPR
                     AR"
     gene            complement(6490..7725)
                     /locus_tag="CLV43_RS18665"
                     /old_locus_tag="CLV43_105223"
     CDS             complement(6490..7725)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="CLV43_RS18665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105223"
                     /product="histidine kinase"
                     /protein_id="WP_211304409.1"
                     /transl_table=11
                     /translation="MDDDDWSSPLAKRLRRGGLIGVDCAVATTYTLVLFLAPGIGPDAG
                     LPLWARCLLAAGIGLPGAVRRVWPLPVFVLVVTLTTVSVAMGLTNEPFLATAFAVYLVA
                     LTAPRRMWLPTLGIALCSAGLVLLEVVLGRPGWQPSAPGWFLAGFAVMGVAWTLGRTAR
                     ERRASAARAADASTERAVGEERLRIARELHDIVAHSIGVIAVKAGVARVVAHRAGRHGG
                     DADPGDQAAEEVYGALCTIETTSRSALEEMRRMLDVLRSAADAPRPPDELAPAPGPADL
                     PELVDRVGMVGVQAHLDVRGVADLPQGVGLSVYRIVQEALTNVVKHAAPARCRVTVDGS
                     DREVLVEVTDDGHAAGPGRSGSPGGHGLIGMRERVTLYGGDFSSGWLPGGGFRVTARLP
                     YAPEHGPARESS"
     misc_feature    complement(7567..7569)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7893..8819
                     /locus_tag="CLV43_RS18670"
                     /old_locus_tag="CLV43_105224"
     CDS             7893..8819
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006238533.1"
                     /locus_tag="CLV43_RS18670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105224"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_106188487.1"
                     /transl_table=11
                     /translation="MIEIRDLSKRYGSVVAVDGLNFDVLPGRVTGFLGPNGAGKSTTMR
                     MIMGLDRPSTGSARIDGKPYRRLRDPLRRVGALLEAGAAHGGRTAYHHLLWLAQSNRIG
                     RRRVREVIELVGLDSVADKPVGEFSLGMSQRLGIAGALLGDPDALLFDEPVNGLDPEGI
                     HWIRTLMRGLAAEGRSVFVSSHLMSEMALTADHLVVIGRGRLLADTGMAEFVQRDASSY
                     TRIRTPEPERMRQVLDAAGIQVRTGADGALEARGPRQRTIGELAAVNGLIVDELSPQAA
                     SLEEAFMRLTAEAVEYHAGDLPEGGRR"
     gene            8816..9589
                     /locus_tag="CLV43_RS18675"
                     /old_locus_tag="CLV43_105225"
     CDS             8816..9589
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680634.1"
                     /locus_tag="CLV43_RS18675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105225"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_106188488.1"
                     /transl_table=11
                     /translation="MTATVQQAVLTSEWTKARTLRSTTWPLLLTVVASVGLSVAFGLYL
                     RGSFDRMPVADQRGFNTAEFAVGSVVYGQILLVAFGVLVVCSEYSGGTIRTSLAAVPRR
                     GTFYSAKVLVGTALALVVSAVTVAGAYLAAHVALGSRSGPLLGPDESRILVGSTLYLTL
                     ICAFSIGVATMLRSAALSLGTLIPFFFVVSNILGHVPVVREIGQYLPDQAGHQIMVATP
                     RPDSPLGPWTGLLVMAAWAVVALGGGYVLLTRRDA"
     gene            9739..9870
                     /locus_tag="CLV43_RS18680"
                     /old_locus_tag="CLV43_105226"
     CDS             9739..9870
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="CLV43_RS18680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105226"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_106188489.1"
                     /transl_table=11
                     /translation="MTAEDGVYEPPTAIEAGDFAGVTLGIPPARDPVDWTFYFHALI"
     gene            10001..11851
                     /locus_tag="CLV43_RS18690"
                     /old_locus_tag="CLV43_105227"
     CDS             10001..11851
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="CLV43_RS18690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105227"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_170155897.1"
                     /sec_met_domain="Asn_synthase (E-value: 3e-31, bitscore:
                     104.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFLMLPDHPASEGLARRAARFGAARVVPHDSGRPWLVGNWSPGE
                     LALVTAGRRRLAVFGRTRLDTGSTERVLGHVNSLHGLDVVAAKLPGAVHLLASVDGDVR
                     GQGSISTARQLFHAQVDGVAVAADSPGPLAALRGADLDERTLALRLVVPAAPWPLSLRT
                     MWTGVHQVPVGHWLGLTPDGGHRTVRWWRPPAADQPLSEVAGVLRAALMDSVAVRVAGR
                     TTGADLSGGLDSTSLCFLAAAAGTDLITHHWQARAAANDDTEWARKAAAMLPEARHRVV
                     APKDAPTWYEGQGGPVDRGDDVEGPLSWDRNRLHSEHQARADAADGADTHLIGVGGDEL
                     FSTLPTYLWSLVRRHPLRSLPEIHHRRVANRWGLAATIRGLADRSPFARSLATAADVLT
                     DPPPPDSDPGLGWGGGWRRLPTWTTPEAADAVRGMLREAADAHPEPLAEDQVRHQMIEY
                     AVYSGGAVRQMRLALGGFGVDWEAPLLDDRVVEATLSVRIEDRAGRGLYKPVLVEAMRG
                     VLPEAVLARRTKGEYSAEAYDGLRRNRRALVGMCEDLALGRLGLVDHRLLRAATLDPGA
                     KIGQLIHLENTLSCENWLRSPSSAPPGSQSTVPAVPMGDL"
     gene            11851..12111
                     /locus_tag="CLV43_RS18695"
                     /old_locus_tag="CLV43_105228"
     CDS             11851..12111
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="CLV43_RS18695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105228"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_106188492.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1.6e-10,
                     bitscore: 36.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 6.9e-23,
                     bitscore: 75.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-11, bitscore: 40.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVVLLPDVSATDVDEGLVLLDQRHGGYWLLNRTGAASLRSLLAG
                     STPEEAAGRLVEKYPESAGRALEDVHSLLATLTEARLVVAS"
     aSDomain        11857..12021
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CLV43_RS18695_Lasso_Fused_RRE.1"
                     /evalue="8.00E-12"
                     /identifier="RREFam003.1"
                     /label="CLV43_RS18695"
                     /locus_tag="CLV43_RS18695"
                     /protein_end="57"
                     /protein_start="2"
                     /score="36.1"
                     /tool="antismash"
                     /translation="VVLLPDVSATDVDEGLVLLDQRHGGYWLLNRTGAASLRSLLAGST
                     PEEAAGRLVE"
     aSDomain        11866..12102
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CLV43_RS18695_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.40E-24"
                     /identifier="RREFam002.1"
                     /label="CLV43_RS18695"
                     /locus_tag="CLV43_RS18695"
                     /protein_end="84"
                     /protein_start="5"
                     /score="75.7"
                     /tool="antismash"
                     /translation="LPDVSATDVDEGLVLLDQRHGGYWLLNRTGAASLRSLLAGSTPEE
                     AAGRLVEKYPESAGRALEDVHSLLATLTEARLVV"
     gene            12108..12524
                     /locus_tag="CLV43_RS18700"
                     /old_locus_tag="CLV43_105229"
     CDS             12108..12524
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="CLV43_RS18700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105229"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_106188493.1"
                     /sec_met_domain="PF13471 (E-value: 6.7e-29, bitscore: 95.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQVVAEPRSRLSWSRHVTTRCAVALARLLILLPPLRLRQVLRV
                     LSRGARPATATQALRARRATVSVSARCAGHGCLQRSVATVLLCRMSGRWPDWCTGVRTR
                     PFRAHAWVEVDGVPVGEVDGMAGFHPTMTVRIGS"
     gene            12521..13489
                     /locus_tag="CLV43_RS18705"
                     /old_locus_tag="CLV43_105230"
     CDS             12521..13489
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020660054.1"
                     /locus_tag="CLV43_RS18705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105230"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_106188494.1"
                     /transl_table=11
                     /translation="MTDDAVVRATGLGKDYGARTAVDGVDLEVAPGQVFGFLGPNGAGK
                     STTIGMLCTVIRPTRGRAEVAGHDVLRSPDEVRQNIGLLFQESTLDADLTAVENLRFQA
                     ELYGLPRRHARTRIDTMLDLVDLADRRDDPVRLFSGGMCRRLEIARGLLHTPKVLFLDE
                     PTTGLDAQTRVAIWEHLHRMREEAGLTVFLTTHHLSEAENCDRIAIIDRGGVVAEGPPA
                     ALKAVVGTDLVTLRTGDDQAALRAVRTRFGLDGDVGAEGLRIRAANGAHLVPRLCAELT
                     VPVHSVVVTEPTLDEVFLHHTGRTIREPGPRTAGPAVGSRS"
     gene            13493..14326
                     /locus_tag="CLV43_RS18710"
                     /old_locus_tag="CLV43_105231"
     CDS             13493..14326
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="CLV43_RS18710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105231"
                     /product="ABC transporter permease"
                     /protein_id="WP_211304410.1"
                     /transl_table=11
                     /translation="MPRTVDPAAPAPVHTARLGRELRAVRVLWLREVIRFGRNRLRVAM
                     ALVGPLVFLLILGTGLSAVMGGADFRGYLFPGVLFMAVQAPALAVGISIVWDRQSGFLR
                     QMLVAPVRRGALVAGLCLGGATAGTFYGLCVLALAGVVGVPYSPRLVLVVLELALISFT
                     FTAMGVLAAVCIRRIESFQVVINLAMTPLLFLSGAVFPASGLPGWLAVAVQANPMTYAV
                     DAVRRTMPGGTAGLPGDTGPQWWGTTPPLTLELGLVALLAALAVTVASKRFAHTD"
     gene            complement(14365..15507)
                     /locus_tag="CLV43_RS18715"
                     /old_locus_tag="CLV43_105232"
     CDS             complement(14365..15507)
                     /NRPS_PKS="Domain: Abhydrolase_1 (101-192). E-value:
                     4.8e-17. Score: 54.3. Matches aSDomain:
                     nrpspksdomains_CLV43_RS18715_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226157.1"
                     /locus_tag="CLV43_RS18715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105232"
                     /product="epoxide hydrolase family protein"
                     /protein_id="WP_106188496.1"
                     /sec_met_domain="PF00561 (E-value: 2.8e-13, bitscore: 45.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.9e-09, bitscore:
                     32.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEHNALTPFRVDIPQTDVDDLRDRLARTRWPIPVPGRDDRTDFS
                     RGIPLVYLKELAEYWRDGFDWRAQERKLNEHEQFTTVVDGQTFHVVHVRSANPEATPLV
                     LNHGWPGSFVDYLRLIPLLTDEFHVVIPALPGFGFSTPLSGTGWELARTTDAYAEIMTR
                     LGYDRFGAHGTDVGAGTTGRLAATHPERVIGTHIGSDPRLLGLLGVKFPFPEGLSDAEV
                     AQIEAVRTRDAADHGYLLMQDHRPDTIGPALTDSPVAQLAWIAEKFRTRSGDGYRTPDE
                     TVDRDQLLTNVSLYWFTRSGASSAQFYYESEHSALDLVMASGVPSGWAVFDTHPLLRRA
                     IDPRKMIGHWSEFTEGGHFPAMEEPKLLADDLRTFFRGIS"
     aSDomain        complement(14932..15204)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CLV43_RS18715_Abhydrolase_1.1"
                     /evalue="4.80E-17"
                     /label="CLV43_RS18715_Abhydrolase_1.1"
                     /locus_tag="CLV43_RS18715"
                     /protein_end="192"
                     /protein_start="101"
                     /score="54.3"
                     /tool="antismash"
                     /translation="PLVLNHGWPGSFVDYLRLIPLLTDEFHVVIPALPGFGFSTPLSGT
                     GWELARTTDAYAEIMTRLGYDRFGAHGTDVGAGTTGRLAATHPERV"
     gene            15571..16551
                     /locus_tag="CLV43_RS18720"
                     /old_locus_tag="CLV43_105233"
     CDS             15571..16551
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226156.1"
                     /locus_tag="CLV43_RS18720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105233"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_106188497.1"
                     /transl_table=11
                     /translation="MLETSARLLELLSLLQLKRDWTSRELADRLHVSTRTVRADIGRLR
                     SLGYPVTARPGVAGGYRLAAGTAMPPLLLDDDEAVAVAVGLGAVATQGRGVEETSLTAL
                     AKLEQVLPSRLRRRVEAVREATSVVPGIEPPLDLSVLGAVAAAIRGHERLRFGYTKPGG
                     DEEARHTEPHRLVTWGALWYLLAWDLDRDDWRVFRVDRMVPRTPTGARFRPRAIPQDDV
                     VEYVVGRISKGAWKYRARLLVHTPAAELAAKIRIPVDVEVVDESTCQVELGSDDPDGLA
                     LWLAQLDVDVEVVDGDELAVAFARLATRFRRAAGDAPTRALLSPP"
     gene            complement(16538..17623)
                     /locus_tag="CLV43_RS18725"
                     /old_locus_tag="CLV43_105234"
     CDS             complement(16538..17623)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018681713.1"
                     /locus_tag="CLV43_RS18725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105234"
                     /product="alkene reductase"
                     /protein_id="WP_106188498.1"
                     /transl_table=11
                     /translation="MTTQPLLQPVRLGALELPNRVVMAPMTRARADNAELAPTDLQATY
                     YAQRASAGLIVTEGTWVSPEAIGFTSVPGIYSDKQTAGWAKVTEAVHEAGGRIFSQFGH
                     VGAVSHPDHLGGRLPAGPSAVNPGETSFTPSGPKDTLTPRAYTAAEIADTIADYRRAAE
                     NARRAGFDGVELHAQVSHLIPQFLNPRLNQRTDAYGGSSEKRARFLLDVLDAVGDVWGG
                     DRVGVKLSPGWTSGTAFTADEETLADYDQLLKKLDDDTLAYLHLVGAPGTIEERVALFS
                     RYRAHYQGNIIANAGFTRDLGNQILDHGGVDAVSFGAPFIANPDLVERFEQGHPLAEDD
                     RETHYGGHAEGYTDYPAFTAG"
     misc_feature    17694..17709
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.07"
                     /tool="antismash"
     misc_feature    17724..17739
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            17776..18384
                     /locus_tag="CLV43_RS18730"
                     /old_locus_tag="CLV43_105235"
     CDS             17776..18384
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666565.1"
                     /locus_tag="CLV43_RS18730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105235"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_106188499.1"
                     /transl_table=11
                     /translation="MPRITKEDKARNRQNILEAASRMFRSQGVDAVGIAELMKEAGLTH
                     GGFYNHFASKNDLVVEVCGAAFAASHGSLAQIVDDGPHQDGSALKRVVDGYLSTAHRDA
                     PDGGCPSASLVTDAGRHSEAVQSAYAAGVEGYLTGFAAEFLREAEENGHDLDPDEARHK
                     AMRLLSEMVGALVLARAVRQVEPELSDEILRAGRGQAVD"
     gene            complement(18452..18916)
                     /locus_tag="CLV43_RS18735"
                     /old_locus_tag="CLV43_105236"
     CDS             complement(18452..18916)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CLV43_RS18735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CLV43_105236"
                     /product="hypothetical protein"
                     /protein_id="WP_106188500.1"
                     /transl_table=11
                     /translation="MGLVPLQRASLVVIIVDAVVIAFGFVTGSALLPRPANLVLAVISM
                     GLLVSTVVLARGGYNFEHPTLPAWAVVVGVIAFFGGAFLFAFPLLTEPASGSFEHENGK
                     YQEVEDGVVVRELTEEQYDAGRAAGQRGAAGLALAFAGGTFLYAGIRHRK"
     gene            complement(18956..19408)
                     /locus_tag="CLV43_RS18740"
                     /old_locus_tag="CLV43_105237"
     CDS             complement(18956..19408)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.4"
                     /locus_tag="CLV43_RS18740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105237"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_106188501.1"
                     /transl_table=11
                     /translation="MDDVDTGTNVWTRVATLPDRRAVVVWMWGEVDHVTIDSFRWAVDQ
                     GFVAAAATRPTRPSPGSPLPTPAEVLVLELSKITFFGSLGLMALLQARERAAENRLRLV
                     VAVPSGHLIRGITRMTEVDHDVELAESVDHALATPSHGRHGRPDCR"
     gene            complement(19474..20448)
                     /locus_tag="CLV43_RS18745"
                     /old_locus_tag="CLV43_105238"
     CDS             complement(19474..20448)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802153.1"
                     /locus_tag="CLV43_RS18745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105238"
                     /product="aldo/keto reductase"
                     /protein_id="WP_245886659.1"
                     /transl_table=11
                     /translation="MSELSLGTGNFGMGWGHGAQVPEARAMYDVYREAGGNFIDTASNY
                     QAGEAEEYLSDILSADREDVVLSTKYTMGTSTGSGLQVTGNSRKAMVQSLEQSLRRLGT
                     DRVDVFWAHVADGSTPIEEVVRAFDDLTRAGKILYAGLSNFPAWRVATGVTLAQQRGWA
                     PLVAIQTEYSLVERGADRELVPMAEAFGLGVLGFTPLGGGFLTGKYRRGETGRAQSSIS
                     QFLHRENDPVKGKVLDAVESVARDLGTTPDRVAIRWSMSKGVIPIVGPRSVDQLTSNLA
                     AGELDISARQLEWLDEVSAPRLGYPHGLWSEPEPVRRNRFAQA"
     misc_feature    20469..20480
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.93"
                     /tool="antismash"
     gene            20483..21604
                     /locus_tag="CLV43_RS18750"
                     /old_locus_tag="CLV43_105239"
     CDS             20483..21604
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024260.4"
                     /locus_tag="CLV43_RS18750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105239"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_106188503.1"
                     /transl_table=11
                     /translation="MRLHSWCRSARAGSSHLPPATIVLITGRTVHNVESSNVHRSSSTE
                     VVLGAHDPFRDALTLARPRTVAPVPFRATAPWGARFSPFPHIKLGVVVEGECWLCVDGM
                     DPLFLSTGDFYLLGNPPLYGLGSSIEAARGSLHHEIPFGGKEISSGTVTYTCSVDFEFQ
                     DSDASTLFSSLPPALLVKADDADGRLLWNIATILVHEMEARKAGRSLVLEHLAQILLVH
                     MLRSHATSSHEPMGWLASVTDDGIGAALRAVHAEPGRRWTLEELAKIAMMSRSTFATTF
                     RSRVGRPPLDHLIEWRMQLARAALRTNDSLTAIAEAVGYQSESAFSTAFRRVVGTSPRE
                     FRAALHARPEDRGSGSPASVVPSGTHHPESRQG"
     gene            complement(21627..22361)
                     /locus_tag="CLV43_RS18755"
                     /old_locus_tag="CLV43_105240"
     CDS             complement(21627..22361)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018681954.1"
                     /locus_tag="CLV43_RS18755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CLV43_105240"
                     /product="FAD:protein FMN transferase"
                     /protein_id="WP_245886662.1"
                     /transl_table=11
                     /translation="MTTRYVEHVMGLPISLALRGAHTADGRARAAWAEVVESLRRVDRV
                     FSTYRPDSFVSRLGRGEVDVADCPAEVAEVLALGELAERRSDGAFRVRRDGVGLDPSGV
                     VKGWAAERAAVHLEALQDTDFCLSAGGDLLCRTLDPDADPWRIGIEDPHDPTRLVAVVP
                     VFTGAVATSGAAHRGQHVVDARTGRPPTAVASVTVVTASLTWADIDATTAYALDRDAAS
                     WLSGQPGRRGLVVWSDATTTRV"
ORIGIN
        1 cgcagcctgt cgaccgagga gtgccagccc agctgcacgc ccaccacggc ctacttccgc
       61 gtgtacgcca ccatgaccga ctcgttccgc gactacggca gggtcctgac caccagctcc
      121 aactacaccc acgcgctgcc ctaccggcac gacccccgcg agttcatccg ccaggtcgcc
      181 cggagctacg cgaccgaccc ggactacgcg accaagatca tcgcgatgat ggacgccaac
      241 gacctctatc gctacgacgt cggcggcgcg acgcagcacg cgccgatgta ccaccagatc
      301 cgcgcggccg acggcacctg gtgcggtttc cggtcactgg ccggctacca gaccacgttg
      361 ccgggcaacg ccaaggacgt cgcggtcgcc gctctcgacg acggcacggc gcaggtgctg
      421 atcatcggcg cggacgacgt ggtctaccac gagatccgcg cagccaacgg cacctggagc
      481 ggcttccaac ccctggcggg caacggcacc accgcacccg ccaagggcaa gcaggtctcc
      541 atcacgggga cggccgacgg caccgcccac gtggtcatcg tcggctggga cgaccgcgtc
      601 taccaccagg tccgcgcagc cgacggcacg tggaccggct tccaacccct ggcgggcaac
      661 ggcaccacgc tccccgcggt gggcaaggac gtggcgatcg ccgcactgcc gggcggcacc
      721 gcccaggtgc tcatcatcgg cgcggacgac gtcgtctacc acgagatccg caccgccaac
      781 ggcacctgga gcggcttcca acccttggcg ggcaacggca ccaccgcacc ggccaagggc
      841 aagcgcgtcg cgatcgcggg catgaccgac ggcaccgccc aggtggtcat cgtcggctgg
      901 gacgaccgga tctaccacca gatccgcgac accgcgggcg gctggagcgg gttccaaccg
      961 gtcaacggca tgaacaccac cctccccgcc gcgggcaagg acgtcgccat cggcacccac
     1021 cccgacggca ccgcccagct gctggtcatc ggcagcgacg acggcatcta ccaccgcatc
     1081 cgcacaacca cctcctggac ccccttcacc accgtcgccg gcaccgacgg cacccccgcc
     1141 aagggctcac gggtagccct ctccggcacc cccgacaaca ccgcgcagat cctcatcacc
     1201 ggccggtgac gcaccacagc cgacaactgg ggcgtggcgg ggagattcgt ctccccgcca
     1261 cgccccagta caccgcccgc tcggacggcc ccggacgggt ccgggcgact accccagtag
     1321 tccacaaagg actcgatcgc cgccgagtcg tgcgccgggc caagggaaag cggccgccgt
     1381 gcggtcggcc gtgctaatct gggatgagcg tgtcggtcga ggggacgatc gaaacggggg
     1441 gattggtcat tcgacgtcga tgagccacgt gcggtgacgt tcgcgcggcg cggttcccgc
     1501 cgcaccacag ccaggcagcc gcacatctgc ggttgctcgc caggtgggaa acagaccctg
     1561 gtacgggatc cgttctcgac atgtccccgc cgccttcgcg ggatcgtcgg accggatcgt
     1621 cccgtcccct tgggctgccc gcgccacggt cccgcggctc acgactgacg tgattgccac
     1681 aagggggatg tgtgtcttac ctggaatatc cgagaattca tttcagcggc aattttcagg
     1741 ccgatgtgcc gaccgtcgac aacatcgagc tctaccacga tccgaacaac ttcgagccca
     1801 ggttccagcg ccccatggtg ctgcccggac agctcaacgg catgtggaac ccgttgggca
     1861 ccggatcgtt ccggctggtc gggtgcacgg tgaccagcct cgtccgcgcc gacggttcca
     1921 ccggcgcgga cgacccgctc atcggcggcc aagtgaccga ggacgacgcg agggtcagcg
     1981 ccaagctggt cgacctcgac gtgaacgacc agcaggtctc catgatcttc ggactgcggg
     2041 tgcggctggt cgacgcggcg ggagcggagc tcttccgcgg ggacttcgag cccgccgcct
     2101 tcgacgacct ctggtcccgg ttcgaccccg gccgccccgg tgacctcagc gcggcctacc
     2161 agtcggtgct gaccaacgtg gtgtgggcgg aggagaccac ccatgccccg ttggccgagc
     2221 tgcgggaggc ctccgccgcc ggactgctct ccgtgaagtt cacgacggac cgggccgaga
     2281 tcgacccgag cagtccgcgg atcacctacg gccgggtgat cggcgcgatc ggcccggcgg
     2341 gacccgacga accgcgccac ttcgtcgcct cccggcggct ccgcaggcag gcgggtggga
     2401 cgttcaacca cgcgccgtgc cgggtcgaca ccacttcggg agtggtgtcg gtcgacctcg
     2461 ccaacagcct cccggtggcc acctcgggcg gacccgtggc ttccgtcggc ccgctgcacc
     2521 tggccgtcct gccaccggac ggcgttcccc gtcgggtggc cgcgctgggc accgtcgacg
     2581 aggagttcct cgagtcccgc gcggggatcg cggacgtccg gctcaccgcc gagcaggtgg
     2641 ccgccgtcgt gtcgaccagg atcgccgtgg tcgactccgc ggcgcgaccg gtcgtcctgc
     2701 tggcggagaa cgccgacgcg acgatgctcc gcgccgacga cccggtgttc cggctccacc
     2761 ccggcggagc cgaggccacc gcgtcgacca ccttgcacgc caccaggttg ggcagcccgg
     2821 ccgccggggt ggagatcacc ctgggcgggg cggacgagac gccgggactg gaccacccgc
     2881 acctgttgac caccgacgtg cggggcaggg cggaggtgac gctggtcggc ggcgatccgg
     2941 gacctcccgg cccgttcggg gacggccgga ccttctcggt gccctacggg ccggtcggga
     3001 gtccggtcga gggccggctg cacgtcctgg tgaccgagct ctaccaggca cccgagcacc
     3061 ccacctgggt ggccgacgtg cagccgatct tccagcggta cgccaacctg taccccgcca
     3121 tgcgcaaggt ccttgacctg tcgaaccacc acgacgtggt gcggtaccgg gatgcgatca
     3181 agtacgcgct gagcctgccc gtcgcgcacc ccaaccacat gccggtgacc agggcgctgt
     3241 ccccggcgaa acgggacatg gtcctgaggt ggctggacag cggtcccgtg cccgcggtgc
     3301 tgcggatcga cacccccgag gcgctgcggt ccgcgttgca gcaggcgctg ctcgtggagc
     3361 aggcggtgat cccgccctac ctgtgcgccc tgttctcctt gaagcccaac cggaacgtcg
     3421 aggtcgccga gatcatccgc ggtgtggtgc ggcaggagat gctgcacatg gcgctggtcg
     3481 gcaacctcct caacgcggtg ggcggtcgcc cgcggatcgg gcgtcccggt ttcgtgccgg
     3541 tgtaccccgg tcggcttcct ggaccggtgc tgccggacct cgaggtgcgg ctgcgccggt
     3601 gctccgtcga gcacatcagg gacgtcttcc tggccatcga gcaacccgag cacccgatcg
     3661 tcgacggccg tcgcttcacc ggcgccgtac tggacaggtc caggatcgag gtggccgaca
     3721 ccggcgagct gctggccgcc tcggaggcgg agctggacgg gctggcggcg tggttcgaca
     3781 aggccgagta ccccaccatg accatcggct ggttctacaa ccaactcgcc cgcgccgtca
     3841 tcggactgga ccgcgagctc gcccagcagg gcgggacgct gttcgccggg gaccccgcgc
     3901 ggcaggtgag ctggccgggg gcgccgggaa cgctcttccg cgtgacggat cggcacaccg
     3961 ccctgctggc catccacgag atcatcgaac agggcgaggg cagtccccac gagctcgacg
     4021 ccgacacccg gcccgcgtcc ggggagctcg gccactacta ccggttcaag gagatcgtcg
     4081 agggcaggcg gctcgttcgc gaccacgagg gcaggtgggt gtacgagggg gcgccggtcc
     4141 gcttcgaccc ggacgacgtc cacccgatgg tcgacgaccc cgacgccagc ctgctgcagg
     4201 acgggtcacg ggccaaggcg caggcggacg tcgtgaacgc cacctacacg aagatgctca
     4261 ccggcctcga ccggatcttc gacggcaacc cccaggagct ggccgacgtc caggggctga
     4321 tgtactcgct ggaggtggag gcgggcaagc tgctggagct gccctccggc ctggaaccgg
     4381 gcaccgtggc cggacccgcc ttccagagtt cggcggtgcc gtggtgaccg agttgcggga
     4441 cgggaccagg cagctgctgg tccggctgcg ggcgctctcg aacgaactgg ccgtgctcac
     4501 ggggcaggcg cgcgacctgg tcgtgtccag gaccggcgcg ggcgtcctgg cccgcgaacg
     4561 ggagcgcctg caccgggaca tgcacgacga cctcggtccc accctcgcgg gcatccggtt
     4621 gcggctcgac accgcgtcgg cccggttgac cgacgacccg gtcgcccggc agctggtgct
     4681 cgacgcggcg gcggagaccg cgcgcaccat ggacgagatc cggcggacca tcgacggcct
     4741 gccaccaccc gacctcgcac gcgaaggcct gtcgacggcg ctgcggatgc tggccgcccg
     4801 gacgtcgcac accagcaccg cggtcgcggt caccgtgccc gaccacccgc cagcgctgtc
     4861 cgaggccacc gaactggcgg cctaccgcat cgccgcggag gcgttgatca acgtgttgcg
     4921 gcacgccgat gcccgtcacg tggacgtcgg gctcttcctc cgcgacgacc acgtggtgct
     4981 cgaagtggcc gatgacggtg ccgggccacc accggcgggc tggtggggcg acggcaccgg
     5041 gctgttctcg atgcgccgcc gcgccgagga gctcggcggc agctgcgtcg tggtgctgcg
     5101 gatggacggc acggcgggaa ccctggtccg cgccgtgctg ccgcgtggtc cggcatgacc
     5161 gtccaagtcc tcctcgtcga cgaccacccg ctgttccgat ccggggtgcg gacggcgttg
     5221 caggacgccg ccgacctccg catcgcgggc gaggccgcga ccggggagca ggccctgggg
     5281 ctgctgcggg agtccgaccc ggcggtggac gtcgtgctgc tggacatccg actgcccgac
     5341 cactcgggga tcgacatcgc gaggacgatc gtcggagagc cgccgaacgg tcggcaggcg
     5401 cctcgggtgc tggtggtgtc ggcgacccag gacgacgccc tggtagtcgc cgcgttgcgc
     5461 gcgggggccc acggctacct cgtcaaaggg gtgtcccgcg acgagctgct gtgggcgatc
     5521 cgcacggtgg ccgccggtgg cgccgtgttc ggtcccgccg tggcgagcag gctgcgggac
     5581 tacttctccg cggtgcacga ggtgcccagc cgcgcggcct tccccgagct gtccgaccgg
     5641 gagctggagg tgctggacct gatcgccagg ggccgcagca accggcacat cgcccgccag
     5701 ctggtggtcg ccgagaagac cgtccgcaac cacatcacgc gggtgttccg gaaacttcag
     5761 gtggatcacc gggacgcggc gatcctgagg gcgaaggacg ccggactggg ggtgtaagtc
     5821 agcgggcccg cggcgagacc agtcccgtct cgtaggcggc gatgacgagc tgggcccggt
     5881 cgcgcgcctc gagcttgcca agcaggtggc tgatgtgggt cttcaccgtg gcggggctca
     5941 ggtgcaggtg ggccgcgatc tccgcgttgg tcatgccgcg ggcgatcagc accagcacct
     6001 cgcgctcgcg accggtgatg cccgacagcg tgccgacccg cggcggcgcg ggctgctgtc
     6061 cactggcgaa ctcggtgatc agtcgccggg tcagggtcgg ggacagcagc ccgtcgccgt
     6121 cggcgacgac ccggatcgcg tccagcaggg tctccggcgg cgcgtccttg agcaggaacc
     6181 cgctggcgcc cgcccgcagc gcggcgaaca cgtaggagtc caggttgaac atggtcagga
     6241 tgaggatccg cacgtcgtcg gtgtccggtg aaccgcagat ccgtctggtc gcctcgatcc
     6301 cgtccatgac cggcatccgc acgtccatca ggaccacgtc gggcttctcg gagcgcgcga
     6361 gggcgacggc ctcgacaccg tcgcgcgcct ccccgaccac ggtgaggccg gggtccgtgt
     6421 cgatcaggac ccggaagctg ccccgcagca gcgcctggtc gtcggcgacc agcacccgga
     6481 ccggaccgct cacgacgact cccgcgcggg gccgtgctcc ggcgcgtacg ggagcctggc
     6541 ggtcaccctg aacccgccac ccggcaacca cccggagctg aagtcgccgc cgtagagggt
     6601 gacccgctcg cgcatcccga tcagaccatg gccgccgggc gacccgctcc ggcccggccc
     6661 ggcggcgtgt ccgtcgtcgg tgacctccac gagcacttcc cggtcggacc cgtccacggt
     6721 cacccggcac cgcgcgggag ccgcgtgctt cacgacgttg gtcaacgcct cctgcacgat
     6781 ccggtagacc gacaacccga ccccctgcgg gaggtcggcc accccgcgga cgtccaggtg
     6841 cgcctggaca ccgaccatgc ccacccggtc caccagttcc ggcaggtcgg cgggccccgg
     6901 cgcgggcgcg agctcgtcgg gaggccgtgg cgcgtccgcc gccgaacgga ggacgtcgag
     6961 catccggcgc atctcctcga gcgcgctgcg gctggtggtc tcgatcgtgc acagggcgcc
     7021 gtacacctcc tccgcggcct ggtcaccggg atcggcgtcg ccgccgtgcc gacccgcgcg
     7081 gtgggccacg accctggcga ccccggcctt gaccgcgatc acgccgatgc tgtgcgccac
     7141 gatgtcgtgc agctccctgg cgatgcgcag gcgctcctcg ccgaccgcgc gctcggtcga
     7201 cgcgtcggcg gcgcgcgccg ccgacgcccg acgttcccgc gccgtcctgc cgagcgtcca
     7261 ggcgacaccc atgaccgcga agcccgccag gaaccacccc ggagcgcttg gctgccagcc
     7321 gggcctgccg aggacgacct ccagcagcac cagacccgcg ctgcacaagg cgatgcccag
     7381 ggtgggcagc cacatgcggc ggggtgcggt gagcgcgacg aggtagaccg cgaacgccgt
     7441 ggcgaggaag ggctcgttgg tcaggcccat cgccaccgac accgtggtca gggtgaccac
     7501 gaggacgaag acgggcagcg gccagacccg tcgcaccgcg ccgggcagtc cgatgcccgc
     7561 ggccagtaag cacctggccc acagcgggag gcccgcgtcc ggtccgatcc ccggagccag
     7621 gaacagcacg agggtgtagg tcgtcgcgac cgcgcagtcg acaccgatca gccctcctcg
     7681 gcgcaaccgc ttggccaacg gcgagctcca gtcgtcgtcg tccacccacc gaccgtagtg
     7741 ggctgggccg gtccacgcct cggaccgtgg tccgacatcc ccgcggccga gttccgcccg
     7801 acagcaccct ccccctcacc ctccgggggg agcgcggagt tcgggtcccg cgccgatgcg
     7861 gccggtcccc cgcacgggcc agccttgtcc gcatgatcga gatacgggac ctgtccaagc
     7921 gctacggctc cgtggtggcc gtggacgggc tgaacttcga cgtcctgcca ggtcgggtga
     7981 ccggcttcct cggtcccaac ggcgcgggca agtcgaccac catgcggatg atcatggggt
     8041 tggaccgccc gagcacggga tcggcgcgca tcgacggcaa gccctaccgg cgactgcgcg
     8101 acccgctgcg ccgcgtcggc gcgctgctgg aggcaggcgc ggcgcacggc ggccgcaccg
     8161 cctaccacca cctgctgtgg ctggcgcaga gcaacaggat cggcaggcga cgggtgcggg
     8221 aggtgatcga gctggtcggg ctggacagcg tcgcggacaa accggtcggc gagttctccc
     8281 tgggcatgag ccagcgcctc ggcatcgcgg gagcactgct cggcgacccg gacgcgctgc
     8341 tgttcgacga gccggtcaac gggctggacc cggagggcat ccactggatc cgcaccctga
     8401 tgaggggact ggccgccgag gggcgctcgg tgttcgtctc cagccacctg atgagcgaga
     8461 tggcgctgac cgcggaccac ctggtcgtca tcggtcgcgg ccgtctgctc gccgacaccg
     8521 ggatggccga gttcgtccag cgcgacgcct cgtcctacac ccggatccgc accccggagc
     8581 cggagcggat gcgccaggtg ctcgacgcgg ccgggatcca ggtgcgcacg ggggcggacg
     8641 gtgccctgga ggcccgcggc ccgcggcagc ggaccatcgg cgagctcgcc gcggtgaacg
     8701 ggctgatcgt cgacgagctc agcccgcagg ccgcctcgct ggaggaggcg ttcatgcgac
     8761 tcaccgccga agcggtcgag taccacgccg gggacctgcc cgaaggagga cgtcgatgac
     8821 cgcgacggtc cagcaggccg tgctcacctc ggagtggacc aaggcccgca ccctccgctc
     8881 cacgacctgg ccgctgctgc tgacggtcgt ggcctccgtc ggcctgagcg tcgcgttcgg
     8941 cctttacctg cgcggttcct tcgaccgcat gcccgtggcc gaccaacgcg gtttcaacac
     9001 cgccgagttc gcggtgggct cggtcgtcta cggccagatc ctgctggtcg ccttcggggt
     9061 gctggtggtc tgctcggagt acagcggcgg cacgatccgc acctccctgg ccgccgtgcc
     9121 gcgtcgcggg acgttctaca gcgccaaggt cctcgtcggc acggcgctgg ccctggtggt
     9181 ctccgcggtc actgtggccg gggcctacct cgcggcgcac gtcgcgctgg gatcgcgcag
     9241 cggcccgttg ctgggccctg acgagtcgcg gatactcgtc ggttccacgc tctacctgac
     9301 gctgatctgc gcgttctcga tcggggtggc gacgatgctg cgcagcgcgg cgttgtcact
     9361 gggcaccctg atccccttct tcttcgtggt ctccaacatc ctcggccacg tcccggtggt
     9421 gcgggagatc ggccagtacc tgcccgacca ggccgggcac cagatcatgg tggcgacgcc
     9481 gcgaccggac tcgccgctcg gcccgtggac cggcctgctg gtcatggccg cctgggcggt
     9541 cgtggcgctc ggcggcggct acgtgctgct gacccggcgc gacgcgtgac cgggattttg
     9601 gggcaggagt ggggccgtgg tcccacgaaa ccgggacaac ggccgccata cagtcgcgtt
     9661 gccagccaga acacggggcc ttggtggaga acggggcccc ggttcgacac cttctagctt
     9721 caggggggag gagacaacat gaccgcagag gacggcgtct acgagccgcc caccgcgatc
     9781 gaggcggggg acttcgccgg cgtcacgctg ggaattccgc cggccaggga cccggtggac
     9841 tggacgttct acttccacgc gctcatctga tccggtgaga cggcggtggc caggacgcga
     9901 ccggccaccc gcgggacgac ggtagtgggt cgcacccacc accgccgtcc cggcaccgaa
     9961 cggtgaagtc gcgaaccgaa gcctttgggg ggaatggacc atggacttcc tgatgctccc
    10021 ggatcacccg gcgtccgagg ggctggcgcg gcgggccgcg cgcttcggag cggcacgggt
    10081 cgtcccgcac gactccggcc gcccgtggct ggtcggcaac tggtcgccag gggaactggc
    10141 gctcgtcaca gcgggccgac gcaggctggc ggtgttcggc cgcacccggc tcgacaccgg
    10201 gtcgaccgaa cgcgtgctcg ggcacgtgaa ctccttgcac ggcctcgacg tggtagccgc
    10261 gaagctgccc ggcgccgtcc acctgctcgc ctccgtcgac ggcgacgtcc gcggccaggg
    10321 cagcatctcc accgctcggc agctcttcca cgcacaggtc gacggcgtgg cggtggccgc
    10381 cgactcccct gggccgctgg ccgcgctcag gggcgccgac ctggacgagc ggaccctcgc
    10441 gttgcggctg gtggttcccg cggccccgtg gccgctgagc ctgcgcacga tgtggaccgg
    10501 ggtgcaccag gtccccgtcg ggcactggtt ggggttgacg ccggacggcg ggcaccggac
    10561 cgtgcgctgg tggcgcccgc ccgccgcgga ccagcccctc agcgaggtcg ccggggtgct
    10621 gagggcggcg ttgatggact cggtcgccgt cagggtcgcc gggcggacaa cgggggccga
    10681 cctgtccggc ggcctcgact cgacgagcct gtgtttcctg gccgcggcgg cgggcacgga
    10741 cctgatcacc caccactggc aggcgcgggc cgcggcgaac gacgacaccg agtgggcccg
    10801 caaggcggcg gcgatgctgc ccgaggcccg gcaccgggtg gtcgccccga aggacgcgcc
    10861 cacctggtac gagggccagg gcggtccggt cgaccgcggc gacgacgtgg agggcccgct
    10921 gtcctgggac cgcaaccggc tgcattccga gcaccaggca cgcgcggacg ccgctgacgg
    10981 agccgacacg cacctcatcg gagtcggcgg cgacgagttg ttcagcaccc tgcccaccta
    11041 cctgtggtcg ttggtgcgca ggcatccgtt gcggagcctg cccgagatcc accaccgcag
    11101 ggtcgccaac cggtgggggc tggccgcgac catccgggga ctggcggacc ggtccccctt
    11161 cgcccggtcg ttggccaccg cggcggacgt gctcaccgat ccgcctcctc cggactccga
    11221 tccggggctc ggctggggag gcgggtggcg gcggctgccc acgtggacca ctcccgaggc
    11281 ggccgacgcg gtgcgcggca tgctccgcga ggcggccgat gcgcaccccg aaccgctggc
    11341 agaggaccag gtccggcacc agatgatcga gtacgcggtg tacagcggtg gtgcggtgcg
    11401 gcagatgcgg ctggcgctgg gcggcttcgg ggtcgactgg gaggcgccgc tgctcgacga
    11461 ccgggtcgtc gaggcgaccc tgtccgtccg gatcgaggac cgggcgggca ggggcctcta
    11521 caagcccgtc ctggtcgagg cgatgcgggg tgtgctgccg gaagccgtcc tggcccgccg
    11581 gaccaagggc gagtacagcg ccgaggccta cgacggcctg cgccgcaacc gccgcgcgct
    11641 cgtcgggatg tgcgaggacc tggcgctggg aaggctcggt ctggtcgacc accggctgct
    11701 ccgcgcggcg acgctcgacc ccggtgccaa gatcggccag ctgatccacc tggagaacac
    11761 cctgtcctgc gagaactggc tgcgttcgcc cagttccgcc cctcctggtt cgcagtccac
    11821 cgttcccgcc gtgccgatgg gagacctgtg atgtccgtgg tgctgttgcc cgacgtgtcg
    11881 gccaccgacg tggacgaggg cctggtgctg ctcgaccagc ggcacggtgg ctactggctg
    11941 ctcaaccgga cgggggcggc cagcctccgg tcgctgttgg cggggagcac tcccgaggaa
    12001 gcggcgggcc ggctggtcga gaagtacccc gagtcggccg gccgagcgct ggaggacgtg
    12061 cactccctgc tggccaccct gaccgaggcc cgactggtgg tggcgtcatg accgtccagg
    12121 tcgtggccga gccccgcagc aggctttcct ggagtcgcca cgtcaccacc cgctgcgccg
    12181 tcgcgctggc ccggttgctg atcctgttgc cgccgctgcg gttgcggcag gtgctgcggg
    12241 tgctcagccg tggcgcccga cccgcgaccg cgacacaggc gttgcgcgcg agacgggcca
    12301 ccgtctcggt cagcgcccgg tgcgccgggc acggctgcct ccagcggtcg gtcgccacgg
    12361 tgctgctgtg ccggatgagc ggtcggtggc cggactggtg caccggggtc cgcacccgac
    12421 cgttccgggc gcacgcctgg gtcgaggtgg acggcgtccc ggtcggggag gtcgacggga
    12481 tggccggttt ccacccgacg atgaccgtcc ggatcggctc gtgaccgacg acgccgtggt
    12541 ccgcgcgacc gggctcggca aggactacgg cgcccggacg gccgtcgacg gggtggacct
    12601 ggaggtggca ccggggcagg tcttcggttt cctcggcccg aacggggcgg gcaagagcac
    12661 gacgatcggc atgctgtgca cggtgatccg ccccaccagg gggcgcgccg aggtcgccgg
    12721 gcacgacgtc ctgcgcagcc cggacgaggt caggcagaac atcggactcc tcttccagga
    12781 gtccactttg gacgccgacc tgaccgcggt cgagaacctg cgcttccagg ccgagctgta
    12841 cgggctcccc cgccgccacg cccgcacgag gatcgacacc atgctcgacc tcgtcgacct
    12901 ggcggaccgc cgcgacgacc cggtccggct gttctccggc ggcatgtgcc gacgcctgga
    12961 gatcgcgaga ggactgctgc acacgcccaa ggtgctattc ctcgacgagc ccacgaccgg
    13021 actggacgcg cagaccaggg tggcgatctg ggaacacctg caccggatgc gcgaggaggc
    13081 gggcctgacc gtcttcctga ccacgcacca cctgtcggag gccgagaact gcgaccggat
    13141 cgcgatcatc gaccgcggcg gcgtggtggc cgaggggcca cccgcggcgc tgaaggcggt
    13201 ggtcggcacc gacctggtga cgctgcgcac cggcgacgac caggccgccc tgcgtgctgt
    13261 gcggacccgg ttcggcctcg acggggacgt cggcgccgag ggtctgcgca tccgggccgc
    13321 caacggcgcc cacctggtcc cccggctgtg cgccgagctc accgtgccgg tccactcggt
    13381 ggtcgtcacc gagccgacgc tggacgaggt cttcctgcac cacaccgggc gcaccatccg
    13441 cgaacccggt ccgcggacgg cgggtcccgc ggtcggatcg aggagctgaa tcgtgccgag
    13501 gacagtcgac cccgcggccc ccgcaccggt gcacaccgcg cgcctcggcc gggagctgcg
    13561 cgcggtgcgc gtgctgtggc tgcgggaggt gatccggttc ggccgcaacc gactgcgggt
    13621 ggccatggca ctcgtcggcc ccctggtgtt cctgctgatc ctgggcaccg gactgagcgc
    13681 ggtgatgggc ggcgcggact tccgcggcta cctgttcccc ggagtgctgt tcatggccgt
    13741 gcaggcaccc gccctcgcgg tcggcatctc gatcgtctgg gaccgccagt ccggattcct
    13801 gcggcagatg ctggtcgcac cggtccgccg cggcgccctg gtggccgggc tctgcctggg
    13861 cggcgcgacg gccggcacgt tctacggact gtgcgtactg gcgctcgccg gagtcgtcgg
    13921 cgtgccctac agcccgcggc tcgtcctggt ggtgctcgaa ctcgccctga tctccttcac
    13981 cttcaccgcg atgggagtgc tcgccgcggt ctgcatccgc cgcatcgagt ccttccaggt
    14041 cgtcatcaac ctggccatga caccgctgct gttcctgtcc ggagcggtct tccccgccag
    14101 tggcctaccg ggctggctcg ccgtcgcggt ccaagccaac ccgatgacct acgcggtcga
    14161 cgcggtgcgc cgcacgatgc ccggtggcac cgccggactc cccggcgaca ccgggcccca
    14221 gtggtggggc accactcccc cgctcaccct ggagctcggc ctcgtcgccc tcctcgccgc
    14281 gctcgccgtg accgtggcga gcaagcggtt cgcccacacc gactgacagg gcctcggacg
    14341 gcgcacttcg tcgaccagga caggtcagga gatgccgcgg aagaacgtgc ggaggtcgtc
    14401 cgcgagcagc ttcggctcct ccatcgcggg gaagtggccg ccttcggtga actcgctcca
    14461 gtggccgatc atcttccgcg ggtcgatcgc gcggcgcagg agggggtggg tgtcgaacac
    14521 ggcccagccg gacggcacgc cggaggccat gaccaggtcg agtgcggagt gttcggactc
    14581 gtagtagaac tgcgcgctcg acgcgccgct gcgggtgaac cagtacaggc tgacgttggt
    14641 gaggagctgg tcgcggtcga ccgtctcgtc cggcgtccgg tagccgtcgc cggacctggt
    14701 ccggaacttc tcggcgatcc acgcgagctg ggcgaccggc gagtcggtga gcgcggggcc
    14761 gatcgtgtcg ggacggtggt cctgcatcag gaggtacccg tgatcggccg cgtcccgggt
    14821 gcgcaccgcc tcgatctggg cgacctcggc gtcggacagc ccctcgggaa aggggaactt
    14881 gacgccgagc aggccgagca accgggggtc gctgccgatg tgcgtgccga tgacgcgctc
    14941 ggggtgggtc gccgcgaggc ggccggtggt gcccgcgccg acgtctgtgc cgtgggcccc
    15001 gaacctgtcg taaccgaggc gcgtcatgat ctcggcgtag gcgtcggtcg tccgcgccag
    15061 ctcccagccg gtccccgaca gcggggtgga gaagccgaag ccgggcaggg cggggatgac
    15121 cacgtggaac tcgtcggtca gcagcgggat gagccggagg tagtcgacga acgatcccgg
    15181 ccagccgtgg ttcaggacca gcggcgtggc ctccgggttg gccgaccgga cgtggacgac
    15241 gtggaacgtc tggccgtcga cgaccgtggt gaactgctcg tgctcgttga gcttccgctc
    15301 ctgcgcacgc cagtcgaacc cgtcgcgcca gtactcggcg agctccttca agtacaccaa
    15361 ggggatgcct cggctgaagt cggtgcggtc gtcccggccc ggcacgggga tcggccagcg
    15421 cgtacgggcc agccggtcgc gcaggtcgtc gacatccgtc tgcgggatgt cgacgcggaa
    15481 cggggtgagt gcgttgtgct cgttcatgac gcggacggtg ccaggcaatg cggaaggcta
    15541 ggttccgcga ttgctgggat catcgagacc atgctggaga cctcggcccg tctgctcgaa
    15601 ctgctgtcgc tgctccagct caagcgcgac tggacgagcc gcgaactcgc cgaccggctc
    15661 cacgtgagca cgaggaccgt gcgcgccgac atcggcaggc tgcgatccct cggctacccc
    15721 gtgaccgcgc gccccggtgt cgcgggcggc taccggctgg ccgccgggac ggcgatgccc
    15781 ccgctgctgc tcgacgacga cgaggccgtc gccgtcgcgg tcggactggg cgcggtcgcg
    15841 acccaggggc gcggagtcga ggagacgtcg ctgaccgcgc tcgcgaagct ggagcaggtg
    15901 ctgccctcac gcctgcgtcg gcgcgtcgag gccgtgcgcg aggcgacgag cgtcgttccg
    15961 gggatcgagc caccgctgga cctctcggtc ctcggcgcgg tcgccgccgc gatccgcggc
    16021 cacgaacgac tccggttcgg ctacacgaaa ccagggggcg acgaggaggc gcgccacacc
    16081 gaaccgcatc ggctggtgac ctggggagcg ctctggtacc tgctcgcgtg ggacctcgac
    16141 cgcgacgact ggcgggtctt ccgggtcgac cgcatggtcc cgcgcacacc gacaggcgcg
    16201 cggttccgac cgcgtgcgat cccgcaggac gacgtcgtcg agtacgtcgt cggccgcatc
    16261 agcaaggggg cctggaagta ccgcgcccgt ctgctcgtgc acacccccgc cgccgagctc
    16321 gccgcgaaga tccgcatccc ggtggacgtc gaggtggtcg acgagtccac gtgccaggtc
    16381 gagctgggct ccgacgaccc ggacgggctg gcgctgtggt tggcgcagct cgacgtcgac
    16441 gtcgaggtgg tcgacgggga cgagctcgcg gtggcgttcg cccgcctcgc cacgaggttc
    16501 cgccgcgcgg cgggcgacgc gcccacccgt gccctgctca gcccgccgtg aaggcggggt
    16561 agtcggtgta gccctcggcg tggccgccgt agtgggtttc ccggtcgtcc tcggccagcg
    16621 ggtggccctg ctcgaagcgc tcgacgaggt cggggttggc gatgaagggg gcgccgaagg
    16681 agaccgcgtc gacaccgccg tggtcgagga tctggttgcc gaggtccctg gtgaagccgg
    16741 cgttggcgat gatgttgccc tggtagtgcg cgcggtagcg ggagaagagg gcgacgcgct
    16801 cctcgatggt gccgggcgcg cccacgaggt ggaggtaggc cagggtgtcg tcgtcgagct
    16861 tcttgagcag ctggtcgtag tcggcgagcg tctcctcgtc cgcggtgaac gcggttccgc
    16921 tggtccagcc gggcgacagc ttcacgccga cgcggtcacc gccccacacg tcgccgacgg
    16981 cgtcgaggac gtccaggagg aaccgggccc gcttctcgct gctgccgccg taggcgtcgg
    17041 tgcgctggtt gagacggggg ttgaggaact gcgggatcag gtgcgacacc tgggcgtgca
    17101 gctccacgcc gtcgaaaccg gcgcggcggg cgttctcggc cgcgcggcgg tagtcggcga
    17161 tggtgtcggc gatctcggcg gcggtgtagg cgcgcggggt gagggtgtcc ttcgggccgg
    17221 agggggtgaa ggacgtctcg ccggggttga cggccgaggg gcccgcgggc aggcggccgc
    17281 cgaggtggtc ggggtgggag accgctccga cgtgcccgaa ctgggagaag atccgcccgc
    17341 ccgcctcgtg gacggcttcg gtgaccttcg cccaccccgc ggtctgcttg tcgctgtaga
    17401 tgccggggac gctggtgaag ccgatcgcct cggggctcac ccaggtcccc tcggtgacga
    17461 tcagcccggc ggaggcgcgc tgcgcgtagt aggtcgcctg caggtcggtg ggcgccagct
    17521 cggcgttgtc ggcgcgggca cgggtcatgg gggccatgac gacgcggttc gggagctcca
    17581 gcgcgccgag tcggacgggc tggagcaggg gctgggtggt catgggcggc ttccttgtgc
    17641 tgaggggtgg atcaggacgc ggggctggtg gcgctcctgg tcgaccagtt attaatgatg
    17701 ggcatcatcg gaaccattgc tataatgaga gacgtcatcg aaaaggtcaa atccggagcg
    17761 cgcgagagga cggcaatgcc gcggatcacc aaggaggaca aggcccgcaa caggcagaac
    17821 atcctcgaag cggcgagccg catgttccgc tcgcagggcg tcgacgcggt cggcatcgcc
    17881 gagctgatga aggaggccgg actcacccac ggcggcttct acaaccactt cgcctccaag
    17941 aacgacctgg tcgtggaggt gtgcggagcc gcgttcgccg cgtcgcacgg gagcctggcc
    18001 cagatcgtcg acgacggtcc tcaccaggac ggctccgcgc tgaagcgggt cgtggacggc
    18061 tacctgtcca ccgcgcaccg cgacgccccg gacggcggct gcccctccgc ctcgctggtc
    18121 accgacgccg gacggcacag cgaagccgtg cagagcgcgt acgccgccgg ggtcgagggc
    18181 tacctgaccg gcttcgccgc cgagttcctg cgcgaagccg aggagaacgg ccacgacctc
    18241 gaccccgacg aggcccggca caaggccatg cgcctgctca gcgagatggt cggcgcgctc
    18301 gtgctcgcca gggccgtgcg ccaggtcgaa cccgagctct ccgacgagat cctgcgggcg
    18361 ggccgcggcc aggccgtcga ctgagccgac ccggttccct cgtcggcgga tcagccccga
    18421 ccagtggtcc gccggttccg cgcgggcgtc ctcacttgcg gtggcggatc ccggcgtaga
    18481 ggaacgtgcc tccggcgaag gcgagagcga ggcctgccgc cccgcgctgg cccgcggcac
    18541 gccccgcgtc gtactgctcc tcggtcagct cacggacgac gacgccgtcc tccacttcct
    18601 ggtacttccc attctcgtgc tcgaaactcc ccgaggcggg ctcggtcagc agcgggaacg
    18661 cgaacaggaa cgccccgccg aagaacgcga tcacccccac cacgaccgcc cacgcgggca
    18721 gcgtcgggtg ctcgaagttg tacccgcccc tggccaacac caccgtcgac accaagaggc
    18781 ccatggagat caccgccagc acgaggttcg ccgggcgcgg caacaacgcg ctgccggtca
    18841 cgaacccgaa cgcgatgacg acggcgtcga cgatgatcac cacgagcgac gcccgctgca
    18901 acggcaccag tcccatgatc agcagactag ggcccgcccc ggtcacctgg accggttatc
    18961 ggcaatccgg cctgccgtgc cggccgtggg acggggtcgc gagcgcgtgg tcgaccgact
    19021 cggccagctc gacgtcgtgg tcgacctcgg tcatccgcgt gatcccccgg atgaggtgac
    19081 cggacgggac cgcgacgacc agccgcagcc tgttctcggc ggctcgctcg cgggcctgca
    19141 gcaacgccat caggccgagc gagccgaaga acgtgatctt cgacagttcc agcaccagca
    19201 cctcggccgg tgtcggcaag ggactaccag gactgggacg ggtgggacgg gtagccgcgg
    19261 ccgcgacgaa accctggtcg accgcccacc ggaaggagtc gatcgtgacg tggtcgacct
    19321 cgccccacat ccacacgacc accgcccggc ggtccggcag cgtcgcgacc cgcgtccaca
    19381 cgttcgtccc cgtgtccaca tcgtccatcc catcacaccg gcggggaatc caccgcacac
    19441 cacgatgccg acggcacggt cgaccgcggt tccctacgcc tgggcgaacc ggttcctccg
    19501 caccggctcg ggctccgacc acagtccgtg ggggtatccc aaccgcggcg cgctcacctc
    19561 gtccagccac tcgagctgac gcgcggagat gtccagctca ccggccgcga ggttggacgt
    19621 gagctggtcc acgctcctcg gtccgacgat ggggatcacc cccttggaca tcgaccacct
    19681 gatcgccacc cggtccggag tcgtgccgag gtcgcgggcg acgctctcga cggcgtccag
    19741 gaccttcccc ttgacggggt cgttttcccg gtggaggaac tggctgatcg agctctgcgc
    19801 gcgacccgtc tcccctcgcc ggtacttgcc cgtcaggaaa ccaccgccga gaggcgtgaa
    19861 accgaggacg cccaggccga acgcctccgc catcggcacc agctcccggt cggcaccgcg
    19921 ctcgacgagg ctgtactcgg tctggatcgc cacgagcggg gcccaccccc gctgctgggc
    19981 gagggtgact cccgtcgcca cccgccatgc ggggaagttg gacagaccgg cgtacaggat
    20041 cttgcccgcg cgggtcaggt cgtcgaaggc ccgcaccact tcctcgatgg gcgtggagcc
    20101 atcggccaca tgggcccaga acacgtccac ccggtcggtc cccagtcggc gcaagctctg
    20161 ctccagggac tggaccatcg ccttgcggct gttcccggtc acctggaggc cgctgcccgt
    20221 cgaggtcccc atggtgtact tcgtcgacag gacaacgtct tcgcgatccg cggagaggat
    20281 gtccgacagg tactcctcgg cctcccccgc ctggtagttg gacgcggtgt cgatgaagtt
    20341 ccctcccgct tcccggtaga cgtcgtacat cgcccgagcc tcgggcacct gagccccgtg
    20401 cccccagccc atcccgaagt tgcccgtccc caacgacagc tccgacaccc gtagccctga
    20461 tcgtccgaga aatcggtatc gcatgcgtct ccactcctgg tgtcgatcgg cgcgagcagg
    20521 ctcttcacac ctgccgcctg ccaccatcgt tctgatcacc gggcgtacag tccataacgt
    20581 ggagtccagc aatgttcacc gatcgtccag cacggaggtc gtcctcggcg cacacgaccc
    20641 cttccgggac gccttgaccc tggcgcgacc ccggaccgtc gctcccgtcc cgttccgcgc
    20701 gacggcgccg tggggagccc ggttctcgcc gttcccgcac atcaagctcg gcgtggtcgt
    20761 ggaaggcgaa tgctggctgt gcgtcgacgg gatggacccc cttttcctga gcacgggcga
    20821 cttctacctc ctcgggaacc cgcccctcta cggcctcggc agttcgatcg aggcggcacg
    20881 cgggtcgctc caccacgaga ttccctttgg tggaaaggaa atctcgtcgg gcaccgtcac
    20941 gtacacgtgc agcgtcgact tcgagttcca ggactccgac gcgtcgaccc tgttctcctc
    21001 gctgcccccg gctctgctcg tcaaggccga cgacgccgac ggaagactgc tctggaacat
    21061 cgcgaccatc ctcgtccacg agatggaggc gcggaaagcc ggcagatccc ttgtcctgga
    21121 gcacctggcc cagatcctcc tggtgcacat gctgaggtcg cacgccacct cgtcccacga
    21181 gcccatgggg tggctcgcct cggtgaccga cgacgggatc ggggcggcgt tgcgcgccgt
    21241 gcacgccgaa ccgggccgtc gctggaccct cgaagagctc gccaagatcg cgatgatgtc
    21301 gaggtcgacg ttcgccacga ccttcaggag cagggtgggc aggcctcctc tggatcacct
    21361 catcgaatgg cggatgcagc tggcgcgggc cgcgctgcgc acgaacgact ccctcaccgc
    21421 catcgcggag gccgtcgggt accagtccga aagcgcgttc agcacggctt tccggcgcgt
    21481 tgtcgggacg tcaccacggg agttccgcgc cgcactgcac gcacggccgg aagaccgcgg
    21541 gtccggcagt cccgcctcgg tggtcccgtc cgggacccac cacccggagt cccggcaggg
    21601 ctgatgacca accgcgacca cgccgttcac acgcgcgtgg tcgtcgcgtc ggaccacacc
    21661 acgagaccgc ggcggccggg ttggccgctc agccaggacg cggcgtcgcg gtcgagggcg
    21721 tacgcggtgg tggcgtcgat gtcggcccag gtcaacgaag ccgtgaccac ggtgacggac
    21781 gcgacggcgg tgggcgggcg gccggtgcgg gcgtcgacga cgtgctgccc gcggtgggcg
    21841 gcgccggagg tggccacggc gccggtgaac accgggacga ccgcgacgag cctggtcggg
    21901 tcgtgcgggt cctcgatgcc gatccgccac gggtcggcgt ccgggtcgag ggtgcggcag
    21961 agcaggtcgc cgcccgccga caggcagaag tcggtgtcct gcaacgcctc caggtgcacg
    22021 gcggcgcgtt cggccgccca ccccttgacc acaccgctgg ggtcgaggcc gacgccgtcc
    22081 cggcggaccc ggaacgcgcc gtcggaccgc cgctcggcca gctcccccag cgccagcacc
    22141 tcggcgacct ccgccgggca gtcggccacg tccacctcac cgcgacccag gcgggacacg
    22201 aaggagtcgg gccggtaggt gctgaacacc cggtccaccc ggcgcagcga ctccaccacc
    22261 tcggcccacg ccgcgcgggc ccggccgtcg gcggtgtgcg cgccgcgcag cgccaggctg
    22321 atgggcagcc ccatgacgtg ctcgacgtac cgggtggtca cagtcccgcc tcgtccagcg
    22381 cgccctgcaa cgactcgacg tacccctcgc tcgtcaccgt cgcgccgctg accatgtcga
    22441 cgtcggcgct ctgggcgtcc agcgcctcct ggacgaggat gggcagggcg cgggcgttga
    22501 tctcctggtc cttgcggttc ccgt
//
