LOCUS       NZ_PVRP01000018        14248 bp    DNA     linear   CON 22-NOV-2024
DEFINITION  Bacillus velezensis strain GBSW11 NODE_18_length_14248_cov_43.5618,
            whole genome shotgun sequence.
ACCESSION   NZ_PVRP01000018
VERSION     NZ_PVRP01000018.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus velezensis
  ORGANISM  Bacillus velezensis
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Bacillus; Bacillus amyloliquefaciens group.
REFERENCE   1  (bases 1 to 14248)
  AUTHORS   Borriss,R., Lasch,P., Wu,L., Wu,H. and Gao,X.
  TITLE     Genotypic and phenotypic analysis of antagonistic Bacillus spp.
            isolated from rhizosphere soil of plants in Tibet
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 14248)
  AUTHORS   Borriss,R., Lasch,P., Wu,L., Wu,H. and Gao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) UG, NordReet, Marienstr. 27a, Greifswald
            17489, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. A5-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 48.2x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002998915.1-RS_2024_11_20
            Annotation Date                   :: 11/20/2024 07:46:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,854
            CDSs (total)                      :: 3,748
            Genes (coding)                    :: 3,672
            CDSs (with protein)               :: 3,672
            Genes (RNA)                       :: 106
            rRNAs                             :: 8, 10, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 9, 2 (16S, 23S)
            tRNAs                             :: 80
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 76
            CDSs (without protein)            :: 76
            Pseudo Genes (ambiguous residues) :: 0 of 76
            Pseudo Genes (frameshifted)       :: 42 of 76
            Pseudo Genes (incomplete)         :: 45 of 76
            Pseudo Genes (internal stop)      :: 7 of 76
            Pseudo Genes (multiple problems)  :: 16 of 76
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:10:33
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 14248
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVRP01000018.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..14248
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     gene            <1..3956
                     /locus_tag="C6355_RS19225"
                     /old_locus_tag="C6355_19215"
     source          1..14248
                     /altitude="4000 m"
                     /collection_date="2005"
                     /db_xref="taxon:492670"
                     /geo_loc_name="China: Tibet"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Bacillus velezensis"
                     /strain="GBSW11"
                     /submitter_seqid="NODE_18_length_14248_cov_43.5618"
     cand_cluster    1..14248
                     /SMILES="NC(CCCN)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(O)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..14248
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<4:>14248](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <5..>14248
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS             <5..3956
                     /NRPS_PKS="Domain: AMP-binding (265-670). E-value:
                     3.3e-107. Score: 350.5. Matches aSDomain:
                     nrpspksdomains_C6355_RS19225_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (776-840). E-value: 1.9e-21. Score:
                     68.0. Matches aSDomain: nrpspksdomains_C6355_RS19225_PCP.1"
                     /NRPS_PKS="Domain: Epimerization (851-1157). E-value:
                     7.5e-146. Score: 478.9. Matches aSDomain:
                     nrpspksdomains_C6355_RS19225_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1167-1309). E-value: 1e-35.
                     Score: 114.8. Matches aSDomain:
                     nrpspksdomains_C6355_RS19225_TIGR01720.1"
                     /codon_start=3
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014418073.1"
                     /locus_tag="C6355_RS19225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6355_19215"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_142396300.1"
                     /sec_met_domain="AMP-binding (E-value: 2.7e-116, bitscore:
                     376.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.1e-17, bitscore:
                     49.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 8.1e-80, bitscore:
                     255.7, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPVLELPADKPRPAVRSFAGGSVSCTLDAETASGLHRIARDHGST
                     LYMVLLAAYNTLLARLSGQEDIIVGSPIAGRPHKDLEPILGMFVNTLAIRTEPKGDKRF
                     TDYLAEVRQAALEAYEHQDYPFEELVERLGVQRDMSRNPLFDAMFILQNMEREEINLAG
                     LKVSRSEHTEHDVSSFDLTLSAAESDGNIRFEMEFSTELFMKETIERWMGHLLNLLRHV
                     AAEPEVTLSKADILDEEEKQKLLIEFNNTQTEFMEKHKLFHQLFEEKAEETPHQTAVIE
                     GTQQISYSQLNERANRLARTLHKYGFGPGKRAAILANRSIEAIVSVLAVMKSGGAYIPV
                     DSHYPEERIRYLLKDSAASVLMVQSEYKELASQLTDHNLFLIQLDHEDQYDICAKNIQP
                     AASPDDTAYIIYTSGTTGTPKGVEVRNRSFTHAALAWRRIYELDLIPVRVLQMASFSFD
                     VFSGDIARALLNGGTLVICPDDVRLEPQQLYRLIDQYRITFMESTPALIVPFMEYIYRR
                     KLALQSVKILVLGSDMIKSQDFYTLHERFGKEMRIINSYGVTEATIDSSYYEAEMSEKP
                     REDDVPIGVPLPNVQMYVLNKDKQVQPIGVFGELYIGGAGVAKGYWGQPELTEGAFSDP
                     LQTGETLYRTGDQACWLPDGTLRFQGRIDKQVKIRGYRIETGEIESVLLKHDQVKEAAV
                     TVMKDAEGQARLAAYIVPKEADISSLRQSLMQELPAYMMPSHIIGLDSMPLTLNGKLDK
                     SALPAEEIHSSQAFVAPGDEKQAMLCRIWEDVLHIQKAGIHHSFFELGGDSIKALQVSA
                     RLAGEGWNMSIRDLFQFPTIAELAKHLTPAVATADQGPIEGSAPLTPIQQRFFEEPGAF
                     ELHYNQAVMLCSEDSLEIDALYQAVCALTEHHDALRMTFTENEHGETVQYNRGITKQYE
                     EIFTLNVIDISEETQPEKRIAAEEKEIQQAMRLDQGPLLHLGVFRQKEADHLLITIHHL
                     IVDGVSWRILLEDLQTAYQQALDGKQIELPPKSDSYIKYAEELFDISKSKALLEEAAYW
                     DSVMSSETAPLPKITDENAGRLQENARTASWILSSEVTKQLLLETQQAYGTDVHELLLT
                     ALGMALHEWTDSEQMLISTEGHGRQGHMPDIDMSRTAGWFTSVYPVLLDMRVPGGSGEK
                     TAHRIKTVKDMMRRVPHHGTGYGLLRYSRNILYKDPEISFNYLGAFDGLEGTLKMSPFK
                     PQHDIAAGRIREFDLDINAMVAAGQLEVKAVYTDVFAPGAIEFFMNRFHTHLEDIIAHC
                     SGKKEREKTLTDYSHTELTAQALSSIEDLVKGL"
     CDS_motif       201..290
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0001"
                     /evalue="4.10E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="C6355_RS19225"
                     /protein_end="95"
                     /protein_start="65"
                     /score="48.1"
                     /tool="antismash"
                     /translation="DIIVGSPIAGRPHKDLEPILGMFVNTLAIR"
     CDS_motif       339..458
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0002"
                     /evalue="3.50E-23"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="C6355_RS19225"
                     /protein_end="151"
                     /protein_start="111"
                     /score="74.1"
                     /tool="antismash"
                     /translation="RQAALEAYEHQDYPFEELVERLGVQRDMSRNPLFDAMFIL"
     aSDomain        801..2015
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19225_AMP-binding.1"
                     /evalue="3.30E-107"
                     /label="C6355_RS19225_AMP-binding.1"
                     /locus_tag="C6355_RS19225"
                     /protein_end="670"
                     /protein_start="265"
                     /score="350.5"
                     /specificity="substrate consensus: Orn"
                     /tool="antismash"
                     /translation="FEEKAEETPHQTAVIEGTQQISYSQLNERANRLARTLHKYGFGPG
                     KRAAILANRSIEAIVSVLAVMKSGGAYIPVDSHYPEERIRYLLKDSAASVLMVQSEYKE
                     LASQLTDHNLFLIQLDHEDQYDICAKNIQPAASPDDTAYIIYTSGTTGTPKGVEVRNRS
                     FTHAALAWRRIYELDLIPVRVLQMASFSFDVFSGDIARALLNGGTLVICPDDVRLEPQQ
                     LYRLIDQYRITFMESTPALIVPFMEYIYRRKLALQSVKILVLGSDMIKSQDFYTLHERF
                     GKEMRIINSYGVTEATIDSSYYEAEMSEKPREDDVPIGVPLPNVQMYVLNKDKQVQPIG
                     VFGELYIGGAGVAKGYWGQPELTEGAFSDPLQTGETLYRTGDQACWLPDGTLRFQGRID
                     KQVKIR"
     aSModule        801..3932
                     /complete
                     /domains="nrpspksdomains_C6355_RS19225_AMP-binding.1"
                     /domains="nrpspksdomains_C6355_RS19225_PCP.1"
                     /domains="nrpspksdomains_C6355_RS19225_Epimerization.1"
                     /domains="nrpspksdomains_C6355_RS19225_TIGR01720.1"
                     /locus_tags="C6355_RS19225"
                     /monomer_pairings="Orn -> D-Orn"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       987..1028
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0003"
                     /evalue="1.70E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="C6355_RS19225"
                     /protein_end="341"
                     /protein_start="327"
                     /score="14.9"
                     /tool="antismash"
                     /translation="LAVMKSGGAYIPVD"
     CDS_motif       1224..1277
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0004"
                     /evalue="1.30E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="C6355_RS19225"
                     /protein_end="424"
                     /protein_start="406"
                     /score="27.0"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGTPKGVEV"
     CDS_motif       1812..1901
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0005"
                     /evalue="7.10E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="C6355_RS19225"
                     /protein_end="632"
                     /protein_start="602"
                     /score="47.1"
                     /tool="antismash"
                     /translation="PIGVFGELYIGGAGVAKGYWGQPELTEGAF"
     CDS_motif       1980..2045
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0006"
                     /evalue="1.50E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="C6355_RS19225"
                     /protein_end="680"
                     /protein_start="658"
                     /score="33.2"
                     /tool="antismash"
                     /translation="FQGRIDKQVKIRGYRIETGEIE"
     aSDomain        2334..2525
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19225_PCP.1"
                     /evalue="1.90E-21"
                     /label="C6355_RS19225_PCP.1"
                     /locus_tag="C6355_RS19225"
                     /protein_end="840"
                     /protein_start="776"
                     /score="68.0"
                     /tool="antismash"
                     /translation="MLCRIWEDVLHIQKAGIHHSFFELGGDSIKALQVSARLAGEGWNM
                     SIRDLFQFPTIAELAKHLT"
     aSDomain        2559..3476
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19225_Epimerization.1"
                     /evalue="7.50E-146"
                     /label="C6355_RS19225_Epimerization.1"
                     /locus_tag="C6355_RS19225"
                     /protein_end="1157"
                     /protein_start="851"
                     /score="478.9"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLIVDG"
                     /tool="antismash"
                     /translation="EGSAPLTPIQQRFFEEPGAFELHYNQAVMLCSEDSLEIDALYQAV
                     CALTEHHDALRMTFTENEHGETVQYNRGITKQYEEIFTLNVIDISEETQPEKRIAAEEK
                     EIQQAMRLDQGPLLHLGVFRQKEADHLLITIHHLIVDGVSWRILLEDLQTAYQQALDGK
                     QIELPPKSDSYIKYAEELFDISKSKALLEEAAYWDSVMSSETAPLPKITDENAGRLQEN
                     ARTASWILSSEVTKQLLLETQQAYGTDVHELLLTALGMALHEWTDSEQMLISTEGHGRQ
                     GHMPDIDMSRTAGWFTSVYPVLLDM"
     CDS_motif       2574..2603
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0007"
                     /evalue="1.80E-03"
                     /label="NRPS-E1"
                     /locus_tag="C6355_RS19225"
                     /protein_end="866"
                     /protein_start="856"
                     /score="11.4"
                     /tool="antismash"
                     /translation="LTPIQQRFFE"
     CDS_motif       2664..2741
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0008"
                     /evalue="8.80E-05"
                     /label="C2_starter_024-063"
                     /locus_tag="C6355_RS19225"
                     /protein_end="912"
                     /protein_start="886"
                     /score="15.2"
                     /tool="antismash"
                     /translation="LEIDALYQAVCALTEHHDALRMTFTE"
     CDS_motif       2949..3014
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0009"
                     /evalue="8.40E-12"
                     /label="NRPS-E2"
                     /locus_tag="C6355_RS19225"
                     /protein_end="1003"
                     /protein_start="981"
                     /score="37.2"
                     /tool="antismash"
                     /translation="LLITIHHLIVDGVSWRILLEDL"
     CDS_motif       3420..3470
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0010"
                     /evalue="8.30E-08"
                     /label="NRPS-E5"
                     /locus_tag="C6355_RS19225"
                     /protein_end="1155"
                     /protein_start="1138"
                     /score="24.4"
                     /tool="antismash"
                     /translation="DMSRTAGWFTSVYPVLL"
     aSDomain        3507..3932
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19225_TIGR01720.1"
                     /evalue="1.00E-35"
                     /label="C6355_RS19225_TIGR01720.1"
                     /locus_tag="C6355_RS19225"
                     /protein_end="1309"
                     /protein_start="1167"
                     /score="114.8"
                     /tool="antismash"
                     /translation="AHRIKTVKDMMRRVPHHGTGYGLLRYSRNILYKDPEISFNYLGAF
                     DGLEGTLKMSPFKPQHDIAAGRIREFDLDINAMVAAGQLEVKAVYTDVFAPGAIEFFMN
                     RFHTHLEDIIAHCSGKKEREKTLTDYSHTELTAQALSS"
     CDS_motif       3525..3584
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19225_0011"
                     /evalue="6.10E-10"
                     /label="NRPS-E6"
                     /locus_tag="C6355_RS19225"
                     /protein_end="1193"
                     /protein_start="1173"
                     /score="31.3"
                     /tool="antismash"
                     /translation="VKDMMRRVPHHGTGYGLLRY"
     aSDomain        3982..4071
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19230_NRPS-COM_Nterm.1"
                     /evalue="3.10E-17"
                     /label="C6355_RS19230_NRPS-COM_Nterm.1"
                     /locus_tag="C6355_RS19230"
                     /protein_end="30"
                     /protein_start="0"
                     /score="53.5"
                     /tool="antismash"
                     /translation="MTQATEIQDIYPLSYMQEGMLFHSLLDSGS"
     gene            3982..11679
                     /locus_tag="C6355_RS19230"
                     /old_locus_tag="C6355_19220"
     CDS             3982..11679
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (0-30). E-value: 3.1e-17.
                     Score: 53.5. Matches aSDomain:
                     nrpspksdomains_C6355_RS19230_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (7-309). E-value:
                     9e-112. Score: 365.0. Matches aSDomain:
                     nrpspksdomains_C6355_RS19230_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (474-867). E-value:
                     1.7e-103. Score: 338.3. Matches aSDomain:
                     nrpspksdomains_C6355_RS19230_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (973-1042). E-value: 3.1e-23. Score:
                     73.8. Matches aSDomain: nrpspksdomains_C6355_RS19230_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1057-1344). E-value:
                     2.2e-103. Score: 337.3. Matches aSDomain:
                     nrpspksdomains_C6355_RS19230_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1509-1905). E-value:
                     1.4e-113. Score: 371.5. Matches aSDomain:
                     nrpspksdomains_C6355_RS19230_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2013-2079). E-value: 7.5e-19.
                     Score: 59.7. Matches aSDomain:
                     nrpspksdomains_C6355_RS19230_PCP.2"
                     /NRPS_PKS="Domain: Epimerization (2090-2396). E-value:
                     5.7e-155. Score: 509.0. Matches aSDomain:
                     nrpspksdomains_C6355_RS19230_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (2407-2558). E-value: 1.6e-46.
                     Score: 149.9. Matches aSDomain:
                     nrpspksdomains_C6355_RS19230_TIGR01720.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015239974.1"
                     /locus_tag="C6355_RS19230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6355_19220"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_106080474.1"
                     /sec_met_domain="Condensation (E-value: 3e-88, bitscore:
                     283.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-16, bitscore:
                     46.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 3.5e-121, bitscore:
                     392.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQATEIQDIYPLSYMQEGMLFHSLLDSGSNAYVEQISFTVSGDL
                     CIDTFQKSLDMLVSRYDIFRTIFIKEVPDLEGPQQVVLSRRDTAVRTEDISDYSEERQQ
                     SIIEEFKETDRHKGFDLQKGPLMRLTLFQTGENRHKCVWTHHHIMMDGWSLGIVLKDFF
                     SMYYANRNGRPVNLGSPAPYSSYIKWLRSRNKEETSAFWSRCLEDYGEVVSVPQTKNKP
                     AQNGYASEHFQFSLESETVQKLTDIARSTGVTLNTLFTSIWGLLLHRYNGTEDAVFGSV
                     VSGRPSAIAGIESMAGLFINTVPVRVRAAGDMTFSSLLKKVQKESLAAEEHSYYPLYDI
                     QNESGLQKDLLNHILVFENYPVQMQTAVNGWKQTESSALSLENFSMAEETNYDLNVVIV
                     PGEEFYVKFSYNAGIYDREDMKRIKGHILEVISCVTEDPDRLLSSISLVPPEEEALIHS
                     FNETNRPYPETTVHGLFEEQAAKTPDQEALRYNGVSWSYKKLNQRANQIAHALREKGAR
                     PDQITAVMLRRSMSTVAALLGIWKSGSAYMPIDAEFPPERISFLLRDSETSLLVTEKDL
                     LPLIPPHFKGSVVIMEETVSQQTAPLPPVSDSGNWAYVIYTSGTTGRPKGVLVQHKAIS
                     NTLQWRREEYGMTEGDIALHLFSYVFDGSLTSLFTPLLSGACVLLTDEDDAKDVLSIKQ
                     KITRHGVSHLLIVPSLYRVLLDSLTKKDAQTLRAVTFAGEAATPDIVEASRGICPNAEL
                     LNEYGPTENSVATTILRNLQKSSRITIGRPIANTSVYMMHGDRLQPVGAVGELCISGKG
                     LADGYFQQKELTDKVFTPHPFREGERLYRTGDAARFLPDGTIEYMGRFDDQVKVRGYRI
                     ELGEIETALRSLSGVKEAAVTVRKMADGEQELAAYVVLENAGVTFKPHAELAGRLPAYM
                     IPGSFTKLTEMPLSVSGKLDRAALPEPKETERTGDYQAPRTMLETELLSIWQEVLKREH
                     ISMRDDFFQIGGQSLKAASLVSNIHKRLQIELAVRHVFEHPTIESMARFLEQRKRGEYA
                     EITPAVAKDLYPLSFAQKRLYALHQLAADSTGYHMPACLELSGRLNRDRLHEAFSALLQ
                     RHEALRTSFVLRNGEPMQHIHAHVDLDLTEIHMPSGNLLQEVMETFVKPFDVEKAPLLR
                     VTLAKVTEERHFLLLDMHHLIADGVSMSVLIQELTDLYRGKELRPLKLQYKDFSVWQHE
                     RFAAEEFKRHERYWLDAIGENIPVLDLPLDKKRPQLPDFSGSVVRTRLQKETAENLRRL
                     MDETGSTLYMILLASYSLFLSKLGGQEDIVVGSPAAGRSRAELDGVIGMFVNTVAMRSR
                     PKGDKTFRAYLEEVKMLALGAAEHQDFPFEELAQKLDTHREVNRNPLFDAMLVLQNSDD
                     FEVNLPGLSVSSHAVKHDISKFDLTLHAEERPDGSLDFHFEYSTALFEKDTIERWAGHF
                     KELLGQIAADYERKLSDIHLLSINERQMLLQAENQTAEYPRHETIVSLFEAQAEKMPDQ
                     IAAVMSHERLTYRELNEKADRIADMLSENGIRSGQIVGFMTERSPNMLIGILGILKAGG
                     AYLPIDPDYPDERISFMLTDSGARVLLTQSGLGISGMDGLPVLYIDKPESVSADRTKEI
                     ITPEQPAYVIYTSGTTGKPKGVMTEHRNVISLITHKGLPFDFGSEDVWTLFHSYCFDFS
                     VWEIFGALLYGGKVVIVPKDTARDPHLYRQLLQSEGVTVLNQTPTAFSGLIHEEAGHTD
                     KLKLRYVIFGGEALQPGMLKSWKEKYPETELVNMYGITETTVHVTCKKLNMDDIERNKS
                     NIGRPLETLHAFVMDAYMNPQPIGIPGELYIGGEGVARGYVNRDDLTASRFITNPHVSG
                     MRLYRTGDIAKRLSNGELEYVGRKDAQVKVRGHRIELGEIKSALQELSSVKEAAVITRA
                     DQHGQHSIYAYTVLHGNEKIKEAEIQASLRAFLPEYMIPARLIALDELPLTANGKLDEK
                     ALPQPELNDSLGNDISLRNETEEMMADIWEELLGVEGLGPNAHFFHLGGDSIKALQVCA
                     RLKQQGYETTVRELFEHQTLGEVSMRLRKVRRVIDQAPVTGDVPLTPIQHWFLSQSLPH
                     DHFNQSVMLRSADRINESAMRKALAQLAVHHDALRMVCGTQNGSVIQYNRAEKLSEEEL
                     FTFETLDVRGKGSLQEEHAAIEQAAACIQTSMRLETGPLVAVGLFHANDGDHLLLSIHH
                     LVIDGVSWRILFEDLTACYRQVLEGKETALPAKTDSYQTYAKQISDYAKSRRLLQEADY
                     WSERERAAVEPLPKDARISSNLLKDTDVMTVTLTKQETEQLLMEANRAYTTETGELLLA
                     ALSLALNRWTGNETFKISMEGHGREEHLEHLDISRTIGWFTSIYPVLVDASFQDQADDG
                     ERLGYHIKRTKDMMRRIPHKGAGYGVLKYISKLWEETESDSPEISFNYLGQFDREIRSS
                     GFGVSPVKAGNEVSPDWERPYTLDISGSVSSECLSMHVVYNRFQYQKETIEVLTGYFHA
                     FLKQIISHCTGKEEREWSAADFSDEELTLEDLSDIMGAVNKL"
     aSDomain        4003..4908
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19230_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="9.00E-112"
                     /label="C6355_RS19230_Condensation_DCL.1"
                     /locus_tag="C6355_RS19230"
                     /protein_end="309"
                     /protein_start="7"
                     /score="365.0"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIMMDG"
                     /tool="antismash"
                     /translation="QDIYPLSYMQEGMLFHSLLDSGSNAYVEQISFTVSGDLCIDTFQK
                     SLDMLVSRYDIFRTIFIKEVPDLEGPQQVVLSRRDTAVRTEDISDYSEERQQSIIEEFK
                     ETDRHKGFDLQKGPLMRLTLFQTGENRHKCVWTHHHIMMDGWSLGIVLKDFFSMYYANR
                     NGRPVNLGSPAPYSSYIKWLRSRNKEETSAFWSRCLEDYGEVVSVPQTKNKPAQNGYAS
                     EHFQFSLESETVQKLTDIARSTGVTLNTLFTSIWGLLLHRYNGTEDAVFGSVVSGRPSA
                     IAGIESMAGLFINTVPVRVRA"
     aSModule        4003..7107
                     /complete
                     /domains="nrpspksdomains_C6355_RS19230_Condensation_DCL.1"
                     /domains="nrpspksdomains_C6355_RS19230_AMP-binding.1"
                     /domains="nrpspksdomains_C6355_RS19230_PCP.1"
                     /locus_tags="C6355_RS19230"
                     /monomer_pairings="Tyr -> Tyr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4012..4053
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0001"
                     /evalue="1.30E-04"
                     /label="C1_DCL_004-017"
                     /locus_tag="C6355_RS19230"
                     /protein_end="24"
                     /protein_start="10"
                     /score="14.1"
                     /tool="antismash"
                     /translation="YPLSYMQEGMLFHS"
     CDS_motif       4075..4188
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0002"
                     /evalue="8.80E-14"
                     /label="C2_DCL_024-062"
                     /locus_tag="C6355_RS19230"
                     /protein_end="69"
                     /protein_start="31"
                     /score="43.7"
                     /tool="antismash"
                     /translation="AYVEQISFTVSGDLCIDTFQKSLDMLVSRYDIFRTIFI"
     CDS_motif       4414..4479
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0003"
                     /evalue="2.30E-10"
                     /label="C3_DCL_135-156"
                     /locus_tag="C6355_RS19230"
                     /protein_end="166"
                     /protein_start="144"
                     /score="32.9"
                     /tool="antismash"
                     /translation="HHHIMMDGWSLGIVLKDFFSMY"
     CDS_motif       4804..4899
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0004"
                     /evalue="1.00E-18"
                     /label="C5_DCL_263-294"
                     /locus_tag="C6355_RS19230"
                     /protein_end="306"
                     /protein_start="274"
                     /score="59.7"
                     /tool="antismash"
                     /translation="DAVFGSVVSGRPSAIAGIESMAGLFINTVPVR"
     CDS_motif       4948..5064
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0005"
                     /evalue="1.40E-18"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="C6355_RS19230"
                     /protein_end="361"
                     /protein_start="322"
                     /score="59.4"
                     /tool="antismash"
                     /translation="QKESLAAEEHSYYPLYDIQNESGLQKDLLNHILVFENYP"
     aSDomain        5404..6582
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19230_AMP-binding.1"
                     /evalue="1.70E-103"
                     /label="C6355_RS19230_AMP-binding.1"
                     /locus_tag="C6355_RS19230"
                     /protein_end="867"
                     /protein_start="474"
                     /score="338.3"
                     /specificity="substrate consensus: Tyr"
                     /tool="antismash"
                     /translation="FEEQAAKTPDQEALRYNGVSWSYKKLNQRANQIAHALREKGARPD
                     QITAVMLRRSMSTVAALLGIWKSGSAYMPIDAEFPPERISFLLRDSETSLLVTEKDLLP
                     LIPPHFKGSVVIMEETVSQQTAPLPPVSDSGNWAYVIYTSGTTGRPKGVLVQHKAISNT
                     LQWRREEYGMTEGDIALHLFSYVFDGSLTSLFTPLLSGACVLLTDEDDAKDVLSIKQKI
                     TRHGVSHLLIVPSLYRVLLDSLTKKDAQTLRAVTFAGEAATPDIVEASRGICPNAELLN
                     EYGPTENSVATTILRNLQKSSRITIGRPIANTSVYMMHGDRLQPVGAVGELCISGKGLA
                     DGYFQQKELTDKVFTPHPFREGERLYRTGDAARFLPDGTIEYMGRFDDQVKVR"
     CDS_motif       5590..5631
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0006"
                     /evalue="3.70E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="C6355_RS19230"
                     /protein_end="550"
                     /protein_start="536"
                     /score="10.9"
                     /tool="antismash"
                     /translation="LGIWKSGSAYMPID"
     CDS_motif       5815..5874
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0007"
                     /evalue="3.90E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="C6355_RS19230"
                     /protein_end="631"
                     /protein_start="611"
                     /score="31.6"
                     /tool="antismash"
                     /translation="AYVIYTSGTTGRPKGVLVQH"
     CDS_motif       6247..6279
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0008"
                     /evalue="1.20E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="C6355_RS19230"
                     /protein_end="766"
                     /protein_start="755"
                     /score="5.7"
                     /tool="antismash"
                     /translation="EYGPTENSVAT"
     CDS_motif       6376..6465
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0009"
                     /evalue="3.80E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="C6355_RS19230"
                     /protein_end="828"
                     /protein_start="798"
                     /score="38.4"
                     /tool="antismash"
                     /translation="PVGAVGELCISGKGLADGYFQQKELTDKVF"
     CDS_motif       6547..6612
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0010"
                     /evalue="3.30E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="C6355_RS19230"
                     /protein_end="877"
                     /protein_start="855"
                     /score="38.3"
                     /tool="antismash"
                     /translation="YMGRFDDQVKVRGYRIELGEIE"
     aSDomain        6901..7107
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19230_PCP.1"
                     /evalue="3.10E-23"
                     /label="C6355_RS19230_PCP.1"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1042"
                     /protein_start="973"
                     /score="73.8"
                     /tool="antismash"
                     /translation="ETELLSIWQEVLKREHISMRDDFFQIGGQSLKAASLVSNIHKRLQ
                     IELAVRHVFEHPTIESMARFLEQR"
     aSDomain        7153..8013
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19230_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.20E-103"
                     /label="C6355_RS19230_Condensation_LCL.1"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1344"
                     /protein_start="1057"
                     /score="337.3"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHLIADG"
                     /tool="antismash"
                     /translation="LYPLSFAQKRLYALHQLAADSTGYHMPACLELSGRLNRDRLHEAF
                     SALLQRHEALRTSFVLRNGEPMQHIHAHVDLDLTEIHMPSGNLLQEVMETFVKPFDVEK
                     APLLRVTLAKVTEERHFLLLDMHHLIADGVSMSVLIQELTDLYRGKELRPLKLQYKDFS
                     VWQHERFAAEEFKRHERYWLDAIGENIPVLDLPLDKKRPQLPDFSGSVVRTRLQKETAE
                     NLRRLMDETGSTLYMILLASYSLFLSKLGGQEDIVVGSPAAGRSRAELDGVIGMFVNTV
                     AMRSRP"
     aSModule        7153..11655
                     /complete
                     /domains="nrpspksdomains_C6355_RS19230_Condensation_LCL.1"
                     /domains="nrpspksdomains_C6355_RS19230_AMP-binding.2"
                     /domains="nrpspksdomains_C6355_RS19230_PCP.2"
                     /domains="nrpspksdomains_C6355_RS19230_Epimerization.1"
                     /domains="nrpspksdomains_C6355_RS19230_TIGR01720.1"
                     /locus_tags="C6355_RS19230"
                     /monomer_pairings="Thr -> D-Thr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       7222..7332
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0011"
                     /evalue="1.00E-16"
                     /label="C2_LCL_024-062"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1117"
                     /protein_start="1080"
                     /score="53.3"
                     /tool="antismash"
                     /translation="YHMPACLELSGRLNRDRLHEAFSALLQRHEALRTSFV"
     CDS_motif       7528..7593
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0012"
                     /evalue="2.80E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1204"
                     /protein_start="1182"
                     /score="29.5"
                     /tool="antismash"
                     /translation="MHHLIADGVSMSVLIQELTDLY"
     CDS_motif       7624..7659
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0013"
                     /evalue="1.40E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1226"
                     /protein_start="1214"
                     /score="14.5"
                     /tool="antismash"
                     /translation="QYKDFSVWQHER"
     CDS_motif       7915..8004
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0014"
                     /evalue="1.30E-15"
                     /label="C5_LCL_267-296"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1341"
                     /protein_start="1311"
                     /score="49.7"
                     /tool="antismash"
                     /translation="DIVVGSPAAGRSRAELDGVIGMFVNTVAMR"
     CDS_motif       8062..8172
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0015"
                     /evalue="1.40E-11"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1397"
                     /protein_start="1360"
                     /score="36.7"
                     /tool="antismash"
                     /translation="ALGAAEHQDFPFEELAQKLDTHREVNRNPLFDAMLVL"
     aSDomain        8509..9696
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19230_AMP-binding.2"
                     /evalue="1.40E-113"
                     /label="C6355_RS19230_AMP-binding.2"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1905"
                     /protein_start="1509"
                     /score="371.5"
                     /specificity="substrate consensus: Thr"
                     /tool="antismash"
                     /translation="FEAQAEKMPDQIAAVMSHERLTYRELNEKADRIADMLSENGIRSG
                     QIVGFMTERSPNMLIGILGILKAGGAYLPIDPDYPDERISFMLTDSGARVLLTQSGLGI
                     SGMDGLPVLYIDKPESVSADRTKEIITPEQPAYVIYTSGTTGKPKGVMTEHRNVISLIT
                     HKGLPFDFGSEDVWTLFHSYCFDFSVWEIFGALLYGGKVVIVPKDTARDPHLYRQLLQS
                     EGVTVLNQTPTAFSGLIHEEAGHTDKLKLRYVIFGGEALQPGMLKSWKEKYPETELVNM
                     YGITETTVHVTCKKLNMDDIERNKSNIGRPLETLHAFVMDAYMNPQPIGIPGELYIGGE
                     GVARGYVNRDDLTASRFITNPHVSGMRLYRTGDIAKRLSNGELEYVGRKDAQVKVR"
     CDS_motif       8695..8736
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0016"
                     /evalue="3.70E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1585"
                     /protein_start="1571"
                     /score="16.9"
                     /tool="antismash"
                     /translation="LGILKAGGAYLPID"
     CDS_motif       8914..8973
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0017"
                     /evalue="3.30E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1664"
                     /protein_start="1644"
                     /score="31.8"
                     /tool="antismash"
                     /translation="AYVIYTSGTTGKPKGVMTEH"
     CDS_motif       9352..9375
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0018"
                     /evalue="2.50E+00"
                     /label="NRPS-A_a5"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1798"
                     /protein_start="1790"
                     /score="2.0"
                     /tool="antismash"
                     /translation="YGITETTV"
     CDS_motif       9490..9579
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0019"
                     /evalue="2.00E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1866"
                     /protein_start="1836"
                     /score="52.1"
                     /tool="antismash"
                     /translation="PIGIPGELYIGGEGVARGYVNRDDLTASRF"
     CDS_motif       9661..9723
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0020"
                     /evalue="3.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="C6355_RS19230"
                     /protein_end="1914"
                     /protein_start="1893"
                     /score="35.1"
                     /tool="antismash"
                     /translation="YVGRKDAQVKVRGHRIELGEI"
     aSDomain        10021..10218
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19230_PCP.2"
                     /evalue="7.50E-19"
                     /label="C6355_RS19230_PCP.2"
                     /locus_tag="C6355_RS19230"
                     /protein_end="2079"
                     /protein_start="2013"
                     /score="59.7"
                     /tool="antismash"
                     /translation="EEMMADIWEELLGVEGLGPNAHFFHLGGDSIKALQVCARLKQQGY
                     ETTVRELFEHQTLGEVSMRLR"
     aSDomain        10252..11169
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19230_Epimerization.1"
                     /evalue="5.70E-155"
                     /label="C6355_RS19230_Epimerization.1"
                     /locus_tag="C6355_RS19230"
                     /protein_end="2396"
                     /protein_start="2090"
                     /score="509.0"
                     /specificity="E activity: active"
                     /specificity="Active site motif: HHLVIDG"
                     /tool="antismash"
                     /translation="TGDVPLTPIQHWFLSQSLPHDHFNQSVMLRSADRINESAMRKALA
                     QLAVHHDALRMVCGTQNGSVIQYNRAEKLSEEELFTFETLDVRGKGSLQEEHAAIEQAA
                     ACIQTSMRLETGPLVAVGLFHANDGDHLLLSIHHLVIDGVSWRILFEDLTACYRQVLEG
                     KETALPAKTDSYQTYAKQISDYAKSRRLLQEADYWSERERAAVEPLPKDARISSNLLKD
                     TDVMTVTLTKQETEQLLMEANRAYTTETGELLLAALSLALNRWTGNETFKISMEGHGRE
                     EHLEHLDISRTIGWFTSIYPVLVDA"
     CDS_motif       10267..10293
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0021"
                     /evalue="2.60E-03"
                     /label="NRPS-E1"
                     /locus_tag="C6355_RS19230"
                     /protein_end="2104"
                     /protein_start="2095"
                     /score="10.9"
                     /tool="antismash"
                     /translation="LTPIQHWFL"
     CDS_motif       10345..10419
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0022"
                     /evalue="1.80E-03"
                     /label="C2_LCL_024-062"
                     /locus_tag="C6355_RS19230"
                     /protein_end="2146"
                     /protein_start="2121"
                     /score="10.7"
                     /tool="antismash"
                     /translation="ADRINESAMRKALAQLAVHHDALRM"
     CDS_motif       10645..10710
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0023"
                     /evalue="4.40E-11"
                     /label="NRPS-E2"
                     /locus_tag="C6355_RS19230"
                     /protein_end="2243"
                     /protein_start="2221"
                     /score="34.9"
                     /tool="antismash"
                     /translation="LLLSIHHLVIDGVSWRILFEDL"
     CDS_motif       11113..11163
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0024"
                     /evalue="1.90E-08"
                     /label="NRPS-E5"
                     /locus_tag="C6355_RS19230"
                     /protein_end="2394"
                     /protein_start="2377"
                     /score="26.3"
                     /tool="antismash"
                     /translation="DISRTIGWFTSIYPVLV"
     aSDomain        11203..11655
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19230_TIGR01720.1"
                     /evalue="1.60E-46"
                     /label="C6355_RS19230_TIGR01720.1"
                     /locus_tag="C6355_RS19230"
                     /protein_end="2558"
                     /protein_start="2407"
                     /score="149.9"
                     /tool="antismash"
                     /translation="LGYHIKRTKDMMRRIPHKGAGYGVLKYISKLWEETESDSPEISFN
                     YLGQFDREIRSSGFGVSPVKAGNEVSPDWERPYTLDISGSVSSECLSMHVVYNRFQYQK
                     ETIEVLTGYFHAFLKQIISHCTGKEEREWSAADFSDEELTLEDLSDI"
     CDS_motif       11224..11283
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0025"
                     /evalue="2.60E-08"
                     /label="NRPS-E6"
                     /locus_tag="C6355_RS19230"
                     /protein_end="2434"
                     /protein_start="2414"
                     /score="26.2"
                     /tool="antismash"
                     /translation="TKDMMRRIPHKGAGYGVLKY"
     CDS_motif       11338..11391
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19230_0026"
                     /evalue="1.50E+01"
                     /label="NRPS-A_a8"
                     /locus_tag="C6355_RS19230"
                     /protein_end="2470"
                     /protein_start="2452"
                     /score="-1.0"
                     /tool="antismash"
                     /translation="YLGQFDREIRSSGFGVSP"
     gene            11695..>14248
                     /locus_tag="C6355_RS19235"
                     /old_locus_tag="C6355_19225"
     CDS             11695..>14248
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (2-30). E-value: 1.5e-16.
                     Score: 51.3. Matches aSDomain:
                     nrpspksdomains_C6355_RS19235_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (7-303). E-value:
                     1e-116. Score: 381.2. Matches aSDomain:
                     nrpspksdomains_C6355_RS19235_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (468-851). E-value: 1.6e-97.
                     Score: 318.7. Matches aSDomain:
                     nrpspksdomains_C6355_RS19235_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007611861.1"
                     /locus_tag="C6355_RS19235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6355_19225"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_142396302.1"
                     /sec_met_domain="Condensation (E-value: 8.2e-88, bitscore:
                     281.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.3e-97, bitscore:
                     312.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGQQPEIQDIYPLSFMQEGMLFHSLLDHDSRAYFEQAVFTINGQL
                     DRERFQKSIDAVFERFDIFRTTFIHKNVAKPRQVVLKNRPSRVQFHDISHLDEKAQDKY
                     TDRFRKEDKDKGFDLQSDPLMRVSILKKAPERYVCIWSHHHIVMDGWCFGIVMKEFLMI
                     YQSLGDGRLPSLEPVQPYGKYIKWLMKQDRKEAEIFWKTRLADLEQSASLPKKSAEPNG
                     ELEQAVFTISEEQTNELKNIAARAGATLNTVFQALWGILLQRVSRCDDAVFGSVVSGRP
                     SDLAGVEKMVGLFINTIPVRVKSGSFSFLELVRHLQQETLQAEAYSYYPLYDIQAQSPL
                     KQALFDHIIVFENVPAQREIENVSQAGSFDFAVEDFTMEEVTNYGCSIKVIPGSSLYIR
                     LNFDTGIYDRVFMKNIETFLRHMMKSVISDPEMSASEIALLDACEARNMLDAFNRTEAV
                     EPPAPTLHGLFARRAALSPHRPALRFPGGMLTYAELDQYTDRLAVWLRQKGIRKESMVG
                     VLAERSPEMVVSVLAVLKAGGAYVPLDPDYPEDRLLYMLDDCGACLLLAQPGLSVSGFS
                     GETLEVSLSALTGETETGAVSEEADSDSLAYIIYTSGSTGTPKGVAVEHRQATAFLSGM
                     QGQFPLTEEDIIVMKSSFSFDASIWQLFWWTMSGASVYLLPAGWEKDPVRMIEAFVSEK
                     VTTAHFIPAMVNSFLDALETEPAETRTRLGRTLTRVFAGGEALSPLTAARFADLLPETV
                     LIHGYGPTEATVDAAFYVCDRKRDSGRTRLPIGKPVPGARLYVLDSGGTIQPAGVAGEL
                     YIAGTGVARGYLNRSELTEERFLDDPFYPGERMYQTGDI"
     aSDomain        11701..11784
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19235_NRPS-COM_Nterm.1"
                     /evalue="1.50E-16"
                     /label="C6355_RS19235_NRPS-COM_Nterm.1"
                     /locus_tag="C6355_RS19235"
                     /protein_end="30"
                     /protein_start="2"
                     /score="51.3"
                     /tool="antismash"
                     /translation="QQPEIQDIYPLSFMQEGMLFHSLLDHDS"
     aSDomain        11716..12603
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19235_Condensation_DCL.1
                     "
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.00E-116"
                     /label="C6355_RS19235_Condensation_DCL.1"
                     /locus_tag="C6355_RS19235"
                     /protein_end="303"
                     /protein_start="7"
                     /score="381.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIVMDG"
                     /tool="antismash"
                     /translation="QDIYPLSFMQEGMLFHSLLDHDSRAYFEQAVFTINGQLDRERFQK
                     SIDAVFERFDIFRTTFIHKNVAKPRQVVLKNRPSRVQFHDISHLDEKAQDKYTDRFRKE
                     DKDKGFDLQSDPLMRVSILKKAPERYVCIWSHHHIVMDGWCFGIVMKEFLMIYQSLGDG
                     RLPSLEPVQPYGKYIKWLMKQDRKEAEIFWKTRLADLEQSASLPKKSAEPNGELEQAVF
                     TISEEQTNELKNIAARAGATLNTVFQALWGILLQRVSRCDDAVFGSVVSGRPSDLAGVE
                     KMVGLFINTIPVRVK"
     aSModule        11716..14247
                     /domains="nrpspksdomains_C6355_RS19235_Condensation_DCL.1"
                     /domains="nrpspksdomains_C6355_RS19235_AMP-binding.1"
                     /incomplete
                     /locus_tags="C6355_RS19235"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       11725..11766
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0001"
                     /evalue="5.00E-05"
                     /label="C1_DCL_004-017"
                     /locus_tag="C6355_RS19235"
                     /protein_end="24"
                     /protein_start="10"
                     /score="15.2"
                     /tool="antismash"
                     /translation="YPLSFMQEGMLFHS"
     CDS_motif       11788..11904
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0002"
                     /evalue="4.90E-15"
                     /label="C2_DCL_024-062"
                     /locus_tag="C6355_RS19235"
                     /protein_end="70"
                     /protein_start="31"
                     /score="47.8"
                     /tool="antismash"
                     /translation="AYFEQAVFTINGQLDRERFQKSIDAVFERFDIFRTTFIH"
     CDS_motif       12121..12186
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0003"
                     /evalue="7.50E-12"
                     /label="C3_DCL_135-156"
                     /locus_tag="C6355_RS19235"
                     /protein_end="164"
                     /protein_start="142"
                     /score="37.6"
                     /tool="antismash"
                     /translation="HHHIVMDGWCFGIVMKEFLMIY"
     CDS_motif       12232..12270
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0004"
                     /evalue="3.70E-03"
                     /label="C4_DCL_171-183"
                     /locus_tag="C6355_RS19235"
                     /protein_end="192"
                     /protein_start="179"
                     /score="10.1"
                     /tool="antismash"
                     /translation="PYGKYIKWLMKQD"
     CDS_motif       12502..12597
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0005"
                     /evalue="5.50E-21"
                     /label="C5_DCL_263-294"
                     /locus_tag="C6355_RS19235"
                     /protein_end="301"
                     /protein_start="269"
                     /score="67.0"
                     /tool="antismash"
                     /translation="DAVFGSVVSGRPSDLAGVEKMVGLFINTIPVR"
     CDS_motif       12643..12759
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0006"
                     /evalue="3.70E-19"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="C6355_RS19235"
                     /protein_end="355"
                     /protein_start="316"
                     /score="61.2"
                     /tool="antismash"
                     /translation="QQETLQAEAYSYYPLYDIQAQSPLKQALFDHIIVFENVP"
     aSDomain        13099..14247
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6355_RS19235_AMP-binding.1"
                     /evalue="1.60E-97"
                     /label="C6355_RS19235_AMP-binding.1"
                     /locus_tag="C6355_RS19235"
                     /protein_end="851"
                     /protein_start="468"
                     /score="318.7"
                     /specificity="substrate consensus: Glu"
                     /tool="antismash"
                     /translation="FARRAALSPHRPALRFPGGMLTYAELDQYTDRLAVWLRQKGIRKE
                     SMVGVLAERSPEMVVSVLAVLKAGGAYVPLDPDYPEDRLLYMLDDCGACLLLAQPGLSV
                     SGFSGETLEVSLSALTGETETGAVSEEADSDSLAYIIYTSGSTGTPKGVAVEHRQATAF
                     LSGMQGQFPLTEEDIIVMKSSFSFDASIWQLFWWTMSGASVYLLPAGWEKDPVRMIEAF
                     VSEKVTTAHFIPAMVNSFLDALETEPAETRTRLGRTLTRVFAGGEALSPLTAARFADLL
                     PETVLIHGYGPTEATVDAAFYVCDRKRDSGRTRLPIGKPVPGARLYVLDSGGTIQPAGV
                     AGELYIAGTGVARGYLNRSELTEERFLDDPFYPGERMYQTGDI"
     CDS_motif       13285..13326
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0007"
                     /evalue="1.60E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="C6355_RS19235"
                     /protein_end="544"
                     /protein_start="530"
                     /score="21.1"
                     /tool="antismash"
                     /translation="LAVLKAGGAYVPLD"
     CDS_motif       13510..13569
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0008"
                     /evalue="4.30E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="C6355_RS19235"
                     /protein_end="625"
                     /protein_start="605"
                     /score="34.5"
                     /tool="antismash"
                     /translation="AYIIYTSGSTGTPKGVAVEH"
     CDS_motif       14080..14121
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0009"
                     /evalue="3.80E+00"
                     /label="NRPS-A_a3"
                     /locus_tag="C6355_RS19235"
                     /protein_end="809"
                     /protein_start="795"
                     /score="1.3"
                     /tool="antismash"
                     /translation="VLDSGGTIQPAGVA"
     CDS_motif       14107..14196
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6355_RS19235_0010"
                     /evalue="3.70E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="C6355_RS19235"
                     /protein_end="834"
                     /protein_start="804"
                     /score="54.4"
                     /tool="antismash"
                     /translation="PAGVAGELYIAGTGVARGYLNRSELTEERF"
ORIGIN
        1 agcttccggt gcttgagctt ccggctgaca agccccgtcc ggctgtcaga agctttgcgg
       61 gcggcagcgt atcgtgcacg cttgacgctg aaacggcatc cggccttcac cgcatcgccc
      121 gggatcacgg ctccactttg tatatggtgc ttctcgccgc gtacaatacg ttactcgcga
      181 gattgagcgg gcaggaagac atcatcgtcg gctcgccgat tgccgggcgt ccgcacaaag
      241 accttgaacc gattctcggc atgttcgtca acacgctggc catcagaacg gagccgaaag
      301 gagacaaacg gtttaccgat tacttggcgg aagtccgcca ggcggcgctt gaggcgtatg
      361 agcatcagga ctatccgttt gaagagctgg tggaacggct cggcgtgcag cgggacatga
      421 gccgcaatcc gctgtttgat gcgatgttta ttcttcagaa tatggagcga gaagagataa
      481 atctggccgg tctgaaggtg tcacgatcag aacataccga acatgatgta tcaagttttg
      541 acctgacctt atcagcggct gaatccgatg gaaacatccg ctttgaaatg gaattcagca
      601 ccgagctttt tatgaaagaa acgattgaac gctggatggg ccacttactg aatctcttgc
      661 gccatgttgc cgccgaaccg gaagtcacac tatcgaaagc tgacattttg gatgaagaag
      721 aaaaacaaaa gttactgatt gagtttaata acacacaaac cgaattcatg gaaaaacaca
      781 aactgtttca ccagttgttt gaagagaaag cagaagaaac gcctcatcag accgctgtta
      841 ttgaaggaac acaacagatc agctattcgc agcttaatga gcgggcaaat cggcttgcgc
      901 gaacattaca caaatatgga ttcggtccag gaaaaagagc agctatattg gcaaaccgtt
      961 cgattgaagc gatcgtcagt gttcttgccg tcatgaaatc gggaggggcg tatataccag
     1021 ttgactccca ttatcctgag gaacggattc gctatttatt aaaagacagc gcggcatccg
     1081 tcttgatggt gcagtcagaa tacaaagaac ttgcttcaca gctgacggat cacaatttat
     1141 ttctcattca gcttgatcat gaagatcaat acgatatttg tgcaaagaat attcagccgg
     1201 cagcgtcacc ggatgatact gcatatatca tatatacttc gggaacaacg ggaacgccga
     1261 agggagtcga agtcagaaat cgcagcttta cgcatgcagc acttgcatgg cgcaggattt
     1321 atgagcttga tcttataccg gtcagagtgc tgcagatggc gagtttctca tttgatgtat
     1381 tttcaggaga tattgcacgc gccctgctaa acgggggaac gcttgtcatt tgtccggatg
     1441 acgtccggct tgagccgcaa cagctttatc ggctcattga tcagtaccgt atcacgttta
     1501 tggagtcgac acccgcgctg attgttccgt ttatggaata tatatatcgc cggaagctcg
     1561 cgctgcaaag tgtaaaaata ctggtactgg gttcagatat gatcaagtcg caggattttt
     1621 atacgcttca tgaacgcttc ggaaaagaaa tgcggatcat taacagctac ggtgtaacag
     1681 aagcgacaat tgattcttcg tattatgaag ccgaaatgag cgaaaagccg cgggaagatg
     1741 atgtgccgat cggtgttccg cttccgaatg tacaaatgta cgtcttaaac aaagacaaac
     1801 aggtccagcc gatcggcgtt ttcggagagc tgtatatcgg aggggccggc gtcgccaaag
     1861 gatattgggg acagcctgag ctgacagagg gcgcattcag tgacccgtta caaacgggag
     1921 aaacgcttta cagaaccgga gatcaggctt gctggctgcc ggatggtact cttcgttttc
     1981 aagggcggat tgataagcag gtaaaaatca gaggctacag aattgagacg ggagaaatag
     2041 aaagtgtgct tttgaaacac gatcaagtca aagaagcggc tgttaccgtg atgaaagatg
     2101 ccgaaggaca agcccgatta gcggcataca tcgttcctaa agaggccgat atctcatcac
     2161 ttcgccagtc tctaatgcag gagctcccgg cttatatgat gccgtcccat attatcggtt
     2221 tagacagcat gcccctgaca ctgaacggca aacttgataa atcggcattg ccggcagaag
     2281 agatacattc atcccaggca tttgtcgcgc ccggcgatga aaaacaggcg atgttatgcc
     2341 ggatttggga agatgtgctt catattcaga aagcgggaat ccatcactct ttctttgagc
     2401 ttgggggaga ttccattaag gcgcttcaag tgtcagcccg actcgccgga gaaggctgga
     2461 acatgtcgat ccgcgatttg tttcaattcc cgacgattgc agaactcgcg aagcacctca
     2521 cgccggctgt tgcaactgct gatcaggggc cgatagaagg aagcgctccg ctgacaccga
     2581 tccagcagag attttttgag gagccgggtg cgtttgagct tcattataac caagcggtca
     2641 tgctgtgcag tgaagacagc ctcgaaatag atgcgctgta tcaggcggtt tgcgcgctga
     2701 ccgaacatca tgatgcgctg cgaatgactt tcactgaaaa tgagcatggg gaaacggttc
     2761 aatataatcg cggaatcaca aagcagtatg aagaaatatt tacgcttaac gtcatagata
     2821 tttcagaaga aacgcagccc gaaaaacgga tagccgctga ggaaaaagaa atacagcagg
     2881 ctatgcgtct tgatcagggg cctctgcttc atctcggagt gttccgtcag aaggaagccg
     2941 accatcttct tataacgatt catcatctta tcgtggacgg cgtgtcatgg aggatattgc
     3001 ttgaagatct gcagacagct tatcagcagg cattggacgg caaacaaatc gaactgccgc
     3061 cgaaaagcga ttcttatata aagtatgccg aagaactttt tgacatttcc aaaagcaaag
     3121 cattgctgga ggaagccgca tactgggaca gcgtgatgtc tagtgaaaca gcgccgctgc
     3181 cgaaaataac tgatgaaaac gccgggcgat tgcaggaaaa cgcgcgcact gcatcgtgga
     3241 tattaagcag cgaagtcacg aaacagctgc tgttggaaac acagcaggca tacggaacag
     3301 atgttcatga attgctttta acggcgcttg gaatggcgct tcatgagtgg acggattccg
     3361 aacagatgct tatcagcact gaggggcacg ggcgccaggg gcatatgcct gacattgata
     3421 tgtcaagaac agcaggatgg tttacatctg tttacccggt gcttttggat atgagagtgc
     3481 cgggcggctc aggcgaaaaa accgctcacc gcataaagac ggtaaaagac atgatgagac
     3541 gggttcctca tcacggaacc ggctacgggc tgctgagata ttcgcgaaac attctttata
     3601 aagacccaga aataagcttt aactatctcg gtgcgtttga cggtcttgaa gggacactga
     3661 agatgtcacc gttcaagccg cagcatgata tagcggccgg gcgcatccgc gaatttgatc
     3721 tggatattaa cgcgatggtg gcggccgggc aactggaggt aaaagccgtt tataccgatg
     3781 tatttgcacc gggggcaatc gagttcttca tgaatcgttt ccatactcac ctcgaggaca
     3841 tcatcgccca ttgttccggc aagaaagagc gggaaaaaac attaacggat tacagccata
     3901 cagaattgac cgctcaagca ctatcaagca ttgaagatct cgtaaaagga ctttaatttc
     3961 ataaaaaggt gtgtggcatt cgtgacacaa gcgacagaaa ttcaagatat ttacccttta
     4021 tcatatatgc aggaaggcat gctgtttcat tcgcttctgg attccggatc aaacgcatat
     4081 gtcgagcaga tttcgtttac agtcagcggg gatttatgca ttgatacatt ccaaaaaagt
     4141 ctggatatgc ttgtcagccg ttatgatatt ttcagaacga ttttcataaa agaagtgcct
     4201 gaccttgaag ggccgcagca ggttgtcctt tcacgccgtg acactgccgt acggactgaa
     4261 gacatttcag attattcgga agaacggcag caaagcatca ttgaggaatt caaggaaacc
     4321 gaccggcata aggggtttga tctgcaaaaa ggccccttaa tgcgcctgac tctttttcaa
     4381 acgggagaaa accgccataa gtgcgtttgg actcaccatc acattatgat ggacggctgg
     4441 agcttgggca ttgtgctgaa agatttcttc agcatgtatt atgcgaaccg gaacgggcgg
     4501 cctgtaaacc tcggcagtcc ggctccgtac agctcttata tcaaatggct ccgaagccgg
     4561 aataaagaag aaacgtcagc gttctggtcg cgctgcttgg aagattacgg agaagtcgtt
     4621 tccgttccgc aaacgaagaa taagccggcg caaaacggtt atgcatctga gcattttcaa
     4681 ttttcccttg agtctgaaac cgtgcaaaaa ctgacagaca ttgcccgaag caccggggtc
     4741 acgctgaata ctttatttac gagcatttgg ggactgcttc tccatcgtta caacggcact
     4801 gaagatgcgg tattcggttc agttgtttcc ggcaggccgt cagctatcgc cggcatcgaa
     4861 tccatggccg gactgtttat caataccgtg ccggtaaggg tgcgcgcggc tggggatatg
     4921 actttttctt ctcttctcaa aaaggtgcaa aaagagtcac tcgctgcaga agagcacagc
     4981 tattatccgc tttatgacat ccaaaacgag agcggcctgc aaaaagatct cttgaaccac
     5041 atcctggttt ttgagaatta tccggttcag atgcagaccg cggtaaacgg ctggaagcaa
     5101 acggaaagca gcgcgctctc acttgaaaac ttttcgatgg cggaagaaac caattacgat
     5161 cttaacgtcg tcatcgttcc gggagaagag ttttatgtga aattcagcta caatgcgggc
     5221 atctacgatc gggaagacat gaaacggatc aaagggcata ttctggaggt catctcctgt
     5281 gtaacggaag atccggacag gcttttatca agcatcagtc tcgtgcctcc ggaggaagaa
     5341 gccttgattc attcgtttaa cgaaacgaac cgtccgtacc ctgagacaac cgttcatggg
     5401 ctgtttgaag aacaggcggc aaaaacgcct gaccaagagg cgttgagata taacggggta
     5461 agctggagct acaagaaatt aaatcagcgg gcgaatcaga ttgcgcatgc gttaagggaa
     5521 aaaggcgcac gccccgacca gatcaccgct gttatgctgc gccgatcaat gagtacggtt
     5581 gccgctctgc tcggaatttg gaagtcgggc agcgcctata tgccgattga tgcggaattc
     5641 ccgcctgaac ggatttcatt tttactgaga gacagtgaaa cctcactgct cgtgaccgaa
     5701 aaggacctgc tccccctcat tccgccgcat ttcaagggca gcgtcgtcat catggaggaa
     5761 acggtttccc agcagaccgc accgcttccg ccggtttctg acagcggaaa ttgggcgtat
     5821 gtcatttaca cctccggaac gacaggccgg ccgaaagggg tgcttgtaca acacaaagcg
     5881 atcagcaata cattgcaatg gcggcgtgaa gaatacggga tgacagaagg ggacatagcg
     5941 cttcatcttt tttcatacgt atttgacggg tcattaacga gtcttttcac tccgcttctg
     6001 tcgggcgcct gtgtattgtt aactgatgaa gatgatgcga aagacgtcct ttcaataaaa
     6061 cagaaaatca cccgacacgg agtgagccat cttctgatcg ttccgtctct gtatcgcgtt
     6121 ctgcttgatt cgctgacgaa aaaggatgcg cagacacttc gggcggtgac atttgccggg
     6181 gaagcggcca ctcctgatat cgtggaagcg agccgcggca tatgcccgaa tgccgagctg
     6241 ctgaatgaat acggcccgac ggaaaacagt gtggccacga cgattctgcg caacctgcaa
     6301 aaaagcagcc ggattacgat cgggcgcccg attgccaaca cttctgtcta tatgatgcac
     6361 ggagatcggc tgcagccggt cggagccgtc ggtgaactgt gtatttccgg aaaaggtctg
     6421 gcggacggat atttccagca aaaagagctg acggacaaag tctttacccc tcatccgttt
     6481 cgtgaaggtg aacggctgta cagaacggga gatgcagccc gatttttacc ggatggaacg
     6541 attgaatata tgggacgctt tgacgatcag gtgaaggtaa gaggttacag aattgaatta
     6601 ggagaaatcg aaacggcact cagaagtctg tccggggtaa aagaggcggc agtcaccgtg
     6661 cgcaaaatgg cggacgggga acaggagctt gcagcttatg tcgtactgga aaatgcgggt
     6721 gtgacattta aaccgcacgc tgaattggcc gggagattac ctgcttatat gataccggga
     6781 agctttacca aattaacgga aatgccgctg tctgtgagcg gaaaacttga tcgggccgca
     6841 cttcctgagc cgaaagaaac cgagagaacc ggtgattatc aagctccgcg cacaatgctt
     6901 gagactgagc tgctgtctat ttggcaagaa gtgctgaaac gggaacacat cagtatgaga
     6961 gatgatttct tccaaatcgg cggacagtcg ctgaaagccg cgtcgcttgt ttcaaacata
     7021 cataaacggc tgcaaattga acttgccgtc cgccatgttt ttgaacatcc gaccatcgag
     7081 agcatggccc gcttccttga acagaggaaa agaggagaat atgcagaaat cacgcctgct
     7141 gtggcaaagg acttgtaccc gctatctttt gcgcaaaaaa ggctctatgc ccttcatcag
     7201 cttgcagcgg acagtacggg ctatcatatg cccgcttgtc tggaactgag cggcagactc
     7261 aaccgggatc gtctgcacga agccttttca gcgctgttac aaaggcatga agcgttacgc
     7321 acttcatttg ttttacgaaa cggggagccg atgcagcaca tacatgcaca tgtcgatctt
     7381 gacctcacag agattcacat gccatccggg aaccttcttc aagaggtgat ggaaactttc
     7441 gtcaaaccgt ttgacgtgga aaaagcgccg cttttgagag tgactttagc caaagtcact
     7501 gaagaacgtc attttctgct gcttgatatg catcatctta tcgcagatgg tgtgtcaatg
     7561 agcgttctga ttcaagaatt gacggattta tacagaggaa aggagttgcg gccgttaaaa
     7621 ctccagtaca aagatttttc cgtctggcag catgagcggt ttgccgctga agaatttaaa
     7681 agacatgagc gttattggct ggatgcgatc ggggaaaaca ttcccgttct tgatctgccg
     7741 ctcgataaaa agcgccctca gcttcctgat ttcagcgggt ccgttgttcg aacgcgcctt
     7801 caaaaggaaa cggcggagaa cttgcgccgg ctcatggatg agacgggttc gacactgtat
     7861 atgattcttt tggcaagcta ctccttgttc ctttctaaat tgggcgggca ggaagacatt
     7921 gtcgtcggtt cacctgcggc cggcagaagc cgcgctgagc ttgacggggt catcggcatg
     7981 tttgtaaata ccgtggcaat gagaagcagg ccgaaagggg ataagacatt ccgcgcttat
     8041 ttagaagagg tgaaaatgct cgccctcggc gcggccgaac atcaggactt cccgtttgaa
     8101 gaacttgccc aaaagcttga tacacaccgg gaagtcaatc gcaatccgct gtttgatgcc
     8161 atgctcgttt tgcaaaacag tgatgatttc gaagtgaacc ttccgggctt atccgtttct
     8221 tcacatgcag tgaagcatga catttcaaaa ttcgacttga cgcttcatgc cgaggaacgg
     8281 ccggatggct cactggattt tcattttgaa tacagtaccg cgttgtttga aaaagatacg
     8341 atcgaacggt gggccggtca ttttaaagag cttttaggac aaatcgcagc ggattacgaa
     8401 cggaagctgt ctgacattca tttgctgagc ataaacgagc ggcagatgct tcttcaagcg
     8461 gaaaatcaaa cggcggagta tccgaggcat gaaacgattg tcagtttatt cgaagcacag
     8521 gcggaaaaaa tgccggatca aattgcagcc gtcatgtctc atgagcgtct cacctaccgc
     8581 gagctcaatg aaaaggcgga tcgaatcgcc gatatgctgt cggaaaacgg catccgctcc
     8641 ggacagattg tcggatttat gaccgaacga tctccgaata tgctgattgg gattctcggt
     8701 attttaaaag cgggaggagc ttatctgccg attgatcctg actatccgga cgagcggatt
     8761 tcatttatgc tgactgacag cggcgcgcgt gttctgttga cgcaatcggg tcttgggata
     8821 tccggaatgg acgggcttcc ggttttatac atcgataagc ctgaatccgt ttcagcagac
     8881 agaacgaaag aaataataac gcctgaacag ccggcttacg tgatttacac atcgggcaca
     8941 acaggaaaac cgaaaggcgt tatgacggaa caccgcaatg tcatcagcct tatcacacat
     9001 aaaggactgc cgtttgattt cggctctgaa gacgtctgga cgctgttcca ttcctattgc
     9061 tttgattttt ctgtctggga aatattcggc gcgctcttat acggcggaaa ggtagttatc
     9121 gtgccgaaag acacagcccg tgatccgcat ttgtaccggc agctgctgca aagtgaaggc
     9181 gtaacggtgc tgaaccaaac gccgacggct ttttccggac tcattcatga agaggccggg
     9241 catacggaca agctgaagct tcgatatgtc attttcggcg gagaagcgct tcagcccggc
     9301 atgctgaaaa gctggaaaga gaagtacccg gagacggagc ttgttaatat gtacggtatt
     9361 acggaaacca cggttcacgt cacatgcaaa aaactgaata tggatgatat tgagagaaac
     9421 aaaagcaata tcggcagacc gctggaaacc cttcatgctt ttgttatgga cgcctatatg
     9481 aatccgcagc cgatcggaat tcccggtgag ctttatatcg gcggggaagg cgtcgcgagg
     9541 ggatatgtaa acagggatga tttaaccgcc tcccgtttca tcacgaatcc gcacgtttcc
     9601 ggcatgcggc tctaccggac gggtgatatc gccaaaaggc tctcaaatgg cgagctggaa
     9661 tatgtcgggc ggaaagatgc gcaagtaaaa gtcagaggcc acagaattga gctgggagaa
     9721 attaaatcag cgctgcaaga gctttcctcc gtgaaagagg ccgccgtgat cacacgtgct
     9781 gatcagcacg gtcagcactc catttacgca tacacggtct tacacgggaa cgaaaagata
     9841 aaagaagcag agattcaggc ctctctcaga gcttttctgc cggaatatat gattcccgcc
     9901 cgcttgatag cgcttgatga actgcctttg acggcgaatg ggaagctgga tgagaaggcg
     9961 ctcccgcagc ctgaattaaa tgatagcctt ggaaatgata tcagcctgag aaatgaaact
    10021 gaagaaatga tggctgacat ttgggaagaa ctcttaggtg ttgaaggcct cggtcccaat
    10081 gctcatttct tccatctcgg cggggattcg attaaagcgc tgcaagtatg tgcgaggctg
    10141 aaacagcagg gctatgaaac gaccgtccgc gagctgttcg agcatcagac actgggagaa
    10201 gtatcgatgc ggctccggaa agtccgccgc gtgattgatc aggctcccgt cacgggagac
    10261 gttccgctga cgccgatcca gcactggttc ttgtcgcaat cattgccgca tgatcatttt
    10321 aatcagtcgg ttatgctccg cagtgcggac agaatcaatg aatctgctat gagaaaagcg
    10381 ttggcacagc ttgcggttca tcatgacgca ttacggatgg tatgcggcac gcaaaacgga
    10441 tcggtgattc aatataacag agcggaaaag ctttctgaag aagaactctt tacgtttgaa
    10501 acgcttgacg tgagagggaa agggtcatta caagaggagc acgccgcaat tgaacaggcg
    10561 gccgcctgta ttcaaacttc catgcggctg gagacgggtc cgctcgtagc tgtcggatta
    10621 tttcacgcta atgatggcga tcatctgctg ctttccattc atcaccttgt cattgacggg
    10681 gtgtcatggc ggattttatt tgaagatctc accgcatgct acaggcaggt gctcgaagga
    10741 aaagaaaccg cgcttccggc aaaaaccgat tcctatcaga cttacgcgaa gcaaatctct
    10801 gattatgcaa aaagccgccg gctgttacag gaagcagact actggtccga aagagaaaga
    10861 gcggcggtcg aaccgcttcc gaaagatgcc cgcatctctt ccaatcttct gaaagataca
    10921 gatgtgatga ccgttacatt gacgaaacag gagactgagc agctgttaat ggaagcgaac
    10981 agagcataca caacagagac gggtgaatta ttgcttgccg cgttaagcct tgcgctgaac
    11041 agatggaccg gaaacgagac attcaaaatc agcatggaag gccacggaag ggaagagcac
    11101 ttggagcatc ttgatatcag cagaaccatc ggttggttta cgtcaattta tccggtattg
    11161 gttgacgcaa gttttcaaga tcaggctgat gacggcgagc ggctcggcta tcacattaag
    11221 cggacaaaag acatgatgcg ccgcattccg cataaaggag cgggatacgg ggtgctgaag
    11281 tatataagca aactctggga agagactgaa tccgattctc ctgaaatcag ttttaactat
    11341 ctagggcagt ttgacaggga gatccgttcc agcggctttg gtgtttctcc cgtaaaagcg
    11401 ggaaatgaag tcagcccaga ctgggaacgt ccgtacacac ttgatatcag cggctccgta
    11461 tcgtcggaat gtctcagcat gcatgtcgtg tacaaccgtt ttcagtatca aaaagaaacg
    11521 attgaagttt tgacgggata ttttcatgcc tttctcaagc agatcatctc gcattgcaca
    11581 ggcaaagagg agcgtgaatg gagcgccgct gatttcagtg acgaggagtt aacgctggaa
    11641 gatctgagtg acattatggg agccgtcaac aaactataga aaaggagtgg cgcaatgggg
    11701 cagcaaccgg aaatacaaga tatatatcct ttatctttta tgcaggaggg catgcttttt
    11761 cattctctgt tggatcatga ctcaagagcc tacttcgaac aagcggtgtt tacgatcaac
    11821 ggacagcttg accgggaacg attccaaaaa agtatagatg ctgtttttga acgattcgat
    11881 attttccgta cgacatttat tcataagaat gtggcgaagc cccgccaagt cgtgttgaaa
    11941 aacaggccga gccgcgttca gtttcatgat atttctcatt tggacgagaa ggcacaagac
    12001 aaatataccg accggttcag aaaagaagat aaagataaag gctttgattt gcaatcagac
    12061 cctctcatga gagtctccat tttgaaaaaa gcgcctgaac gctatgtttg tatctggagc
    12121 catcatcata tcgtcatgga cggctggtgc ttcgggattg tcatgaagga atttctgatg
    12181 atctatcaat ctcttggaga cgggcggctc ccgtctctcg agcctgttca gccatatgga
    12241 aagtatatca aatggctcat gaagcaggat cgtaaagaag ccgagatttt ttggaaaacg
    12301 agacttgccg atcttgagca atcggcgtct cttccgaaaa aatccgcgga accaaacggc
    12361 gaacttgagc aggcggtttt caccatttct gaagagcaga caaatgagct gaagaacatt
    12421 gcggcaaggg cgggagcaac gctgaataca gtgttccagg cactgtgggg cattttgctc
    12481 cagcgtgtca gccgctgtga tgacgccgtt ttcggttctg tcgtttccgg ccggccgtcg
    12541 gatctcgcag gcgtggaaaa aatggtgggc ctgtttatta atacgattcc cgtgcgggtg
    12601 aaaagcggtt cattttcttt tctggagctc gtcaggcatt tgcagcagga gacgctgcaa
    12661 gcagaagcgt acagctatta tccgctgtat gacattcagg cgcaaagccc tttgaagcaa
    12721 gcgctgtttg accacattat cgtgtttgaa aatgtgccgg cccagcgtga aattgaaaat
    12781 gtgagtcagg cgggttcatt tgattttgcg gtagaggatt tcacgatgga ggaagtcaca
    12841 aactacggat gcagcataaa ggtgattccg ggaagttctc tttatatccg cttaaacttt
    12901 gataccggta tatacgatcg tgtttttatg aagaatattg aaacattttt acggcatatg
    12961 atgaagtcag tcatttccga ccctgaaatg agcgcctccg agatcgcatt gcttgatgcg
    13021 tgtgaagcca gaaatatgct ggatgcgttt aaccgtacag aagcggttga accgccggct
    13081 ccgacgcttc acggactgtt tgcccgccgc gccgcgcttt cgccgcatcg tccggcgctc
    13141 cgttttccgg gcggcatgct gacgtacgcc gagctcgatc agtacacgga caggctcgct
    13201 gtttggctcc gccaaaaagg catccgcaaa gaaagcatgg tcggcgtact cgctgaacgc
    13261 tcgccggaga tggtggtttc agtgcttgcc gtgttaaaag cgggcggcgc ctacgtgccg
    13321 cttgacccgg attatcctga ggacaggctg ctctatatgc ttgatgactg cggcgcctgt
    13381 cttctgctcg cacagccggg attatccgtt tccggttttt ccggagaaac gctagaagtg
    13441 tctctttctg ctctgacagg cgagacggag acaggggctg tttctgaaga agcggatagc
    13501 gattcgctcg cttatatcat ttatacgtcc ggttcgacgg gaacaccgaa gggagtggct
    13561 gttgaacacc gtcaggccac cgccttttta tccggcatgc aagggcagtt cccgttgacg
    13621 gaagaggata ttatcgtgat gaaatcatcc ttttctttcg atgcttccat ctggcaattg
    13681 ttttggtgga cgatgtccgg cgcctccgtg tatctgcttc ctgccggctg ggagaaagat
    13741 cctgtgcgga tgattgaagc gtttgtctca gaaaaggtga cgaccgcgca ttttattccg
    13801 gcgatggtca acagcttttt agacgcgctg gaaacagagc ctgcggaaac aagaacacgc
    13861 ctcggcagaa ccttgacacg cgtgtttgcc ggaggggaag ctctttcacc gcttacggct
    13921 gcccggtttg ccgatcttct gccggagacc gtgctcattc acggctatgg gccgacggaa
    13981 gcgacggttg atgcggcgtt ttacgtctgt gaccgaaaac gggacagcgg acggacgcgg
    14041 cttccgatcg gaaaacccgt tcctggtgcc cgtctgtatg tattagatag cggaggaacc
    14101 atccagcctg cgggcgtggc aggagagctg tacatcgcgg ggacaggggt ggcccggggc
    14161 tatctgaacc ggtccgagct gacggaggag cgttttctcg atgatccgtt ttatccggga
    14221 gagcgcatgt atcagacggg cgatatcg
//
