LOCUS       NZ_PVRL01000032        17509 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Bacillus thuringiensis strain NMTD81
            NODE_32_length_17509_cov_20.3759, whole genome shotgun sequence.
ACCESSION   NZ_PVRL01000032
VERSION     NZ_PVRL01000032.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus thuringiensis
  ORGANISM  Bacillus thuringiensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 17509)
  AUTHORS   Borriss,R., Lasch,P., Wu,L., W,H. and Gao,X.
  TITLE     Genotypic and phenotypic analysis of antagonistic Bacillus spp.
            isolated from rhizosphere soil of plants in Tibet
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 17509)
  AUTHORS   Borriss,R., Lasch,P., Wu,L., W,H. and Gao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) UG, NordReet, Marienstr. 27a, Greifswald
            17489, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. A5-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 14.5x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002998815.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 01:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,177
            CDSs (total)                      :: 6,068
            Genes (coding)                    :: 5,840
            CDSs (with protein)               :: 5,840
            Genes (RNA)                       :: 109
            rRNAs                             :: 11, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 1 (5S, 23S)
            partial rRNAs                     :: 6, 5 (16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 228
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 228
            Pseudo Genes (frameshifted)       :: 100 of 228
            Pseudo Genes (incomplete)         :: 142 of 228
            Pseudo Genes (internal stop)      :: 67 of 228
            Pseudo Genes (multiple problems)  :: 63 of 228
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:59:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 17509
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVRL01000032.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     cand_cluster    1..17509
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     gene            <1..1551
                     /locus_tag="C6351_RS31450"
                     /old_locus_tag="C6351_31455"
     CDS             <1..1551
                     /NRPS_PKS="Domain: PCP (25-93). E-value: 3.5e-16. Score:
                     51.1. Matches aSDomain: nrpspksdomains_C6351_RS31450_PCP.1"
                     /NRPS_PKS="Domain: NAD_binding_4 (131-378). E-value:
                     1.6e-49. Score: 160.2. Matches aSDomain:
                     nrpspksdomains_C6351_RS31450_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014895184.1"
                     /locus_tag="C6351_RS31450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31455"
                     /product="thioester reductase domain-containing protein"
                     /protein_id="WP_223266715.1"
                     /sec_met_domain="PP-binding (E-value: 1.1e-13, bitscore:
                     41.9, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4.8e-50, bitscore:
                     160.2, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="DKDALPAWASIIQTNEGYIAPRNRVEQKMVEIWSEVLGIDSSVIG
                     VNDNFFDLGGHSLKIMSTLVKTFSEGWNVTIKDYFELKTINNIAKKIQYGYKVNSHSDT
                     LDIKLTTPPKKLKKTKRHEFSNNSKILLTGATGFLGIHLLEQLLDTTECKIYCLVRGEN
                     KQEANNRLLHMLKFYFKNKFVNYQSLVNQRIFIVQGDLAKQNMGLENELYKELHQQIST
                     VIHAAALTKHFGEYSEFERANVQAVKELLAFVGDTKDLHHISTTGVAGQFVLNETETIF
                     KESDFYVKQNYKDNVYVKSKFLAEYEIFKAILRGTDATIYRVGNLTNRYIDGQHQYNFT
                     ENAFMSKLKFILQYGIVTDVLLSSEVEFTPVDYCSKIITGFVTSNEIHENSKNCVNHIY
                     NHLTLNLNVLVKLLNSMGYPIKVISETEYQQFILELSKDKKKQEDIQNLMTFEEPKDNC
                     YKPINLDSTETQKTLKLLGIQWPIINSEYIQQIINYMTSVTGSNSVAKLFKQSYTLKN"
     source          1..17509
                     /altitude="4000 m"
                     /collection_date="2005"
                     /country="China: Tibet"
                     /db_xref="taxon:1428"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Bacillus thuringiensis"
                     /strain="NMTD81"
                     /submitter_seqid="NODE_32_length_17509_cov_20.3759"
     region          1..17509
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     protocluster    1..17509
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6904:8008](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6905..8008
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     aSDomain        79..282
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6351_RS31450_PCP.1"
                     /evalue="3.50E-16"
                     /label="C6351_RS31450_PCP.1"
                     /locus_tag="C6351_RS31450"
                     /protein_end="93"
                     /protein_start="25"
                     /score="51.1"
                     /tool="antismash"
                     /translation="EQKMVEIWSEVLGIDSSVIGVNDNFFDLGGHSLKIMSTLVKTFSE
                     GWNVTIKDYFELKTINNIAKKIQ"
     aSModule        79..1137
                     /domains="nrpspksdomains_C6351_RS31450_PCP.1"
                     /domains="nrpspksdomains_C6351_RS31450_NAD_binding_4.1"
                     /incomplete
                     /locus_tags="C6351_RS31450"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        397..1137
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6351_RS31450_NAD_binding_4.1"
                     /evalue="1.60E-49"
                     /label="C6351_RS31450_NAD_binding_4.1"
                     /locus_tag="C6351_RS31450"
                     /protein_end="378"
                     /protein_start="131"
                     /score="160.2"
                     /tool="antismash"
                     /translation="LTGATGFLGIHLLEQLLDTTECKIYCLVRGENKQEANNRLLHMLK
                     FYFKNKFVNYQSLVNQRIFIVQGDLAKQNMGLENELYKELHQQISTVIHAAALTKHFGE
                     YSEFERANVQAVKELLAFVGDTKDLHHISTTGVAGQFVLNETETIFKESDFYVKQNYKD
                     NVYVKSKFLAEYEIFKAILRGTDATIYRVGNLTNRYIDGQHQYNFTENAFMSKLKFILQ
                     YGIVTDVLLSSEVEFTPVDYCSKII"
     misc_feature    1843..1859
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.72"
                     /tool="antismash"
     gene            2397..3752
                     /gene="purB"
                     /locus_tag="C6351_RS31455"
                     /old_locus_tag="C6351_31460"
     CDS             2397..3752
                     /EC_number="4.3.2.2"
                     /GO_function="GO:0004018 - N6-(1,2-dicarboxyethyl)AMP
                     AMP-lyase (fumarate-forming) activity [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="purB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001089379.1"
                     /locus_tag="C6351_RS31455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31460"
                     /product="adenylosuccinate lyase"
                     /protein_id="WP_016078039.1"
                     /transl_table=11
                     /translation="MNSTPIDSEIFKDQFGTKQMRTNFSDENLIQLWLNSEVSLAKAEA
                     KLGIIPQNAATNIANAADQNKLDFNKIREGMKKTGHPFVAFLHEFESLCDEESRKYIHW
                     GATTQDIIDTGLTLQIKGAHELIYNQTQEILKICLRLSQQYKSTVMPGRTLGQHALPIT
                     FGYKISIWSDELGRHLERLQQGADRYLVGQLGGAVGTLASLGAQGLAVRKEYVKNLNLI
                     EPLVSWHTSRDRFAEFSMILNMIGATTAKVAEEIISLQGTEIREVEEGYHSGKVGSSTM
                     PHKRNPMTCSYIVGLTKIVNRKSTLAIDSMIQKHERDVTFWQSEWSYISEICITLSGAL
                     EQLKNVLTNLIVNEEQMKKNLFLTKGLIVSENVMLELGKIIGRTTAHDLLYELTMRAFE
                     EDKDLKDILLEDNEIKKYFSDEEINSLTNPESYTGLSEKFVDDVYNKWLSYT"
     gene            complement(3788..5689)
                     /locus_tag="C6351_RS31460"
                     /old_locus_tag="C6351_31465"
     CDS             complement(3788..5689)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NpaA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000684559.1"
                     /locus_tag="C6351_RS31460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31465"
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_106082587.1"
                     /sec_met_domain="NpaA (E-value: 2.1e-188, bitscore: 617.7,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAIVGLGPRGISVFERIVSNILSELKSESYEFFLVDPHPPGGA
                     VWRTDQSPQLLMNTVASQITLFTDDSVQCRGPIVNGPSLLEWANELRDKIDTLDMPTVI
                     TEEIYSLEPNSYPTRALYGYYLKDSFNTILEELPSNIKINLIQDTLINLYPNNEDYTLF
                     LTKSLTPIKAEKVIFTTGHSDQKLTSAEEHFFEFANSNNLNYFPPSNPADVNLDSIEPK
                     TPVIIRGLGLNFFDYMSLLTSGRDGKFEEINDKLNYIPSGKEPLLIAGSRRGLPYHSRG
                     QNQKGSSERHIPLFLKNEVIEQLKHKNNLSFKKEIWPFVKLEVESIYYTTLIRNLYGIE
                     KSCQFLYEFVNCAIEYHKDLLINFGVKSELFFDWHKISCPYGDKKFNSITDFHNWLDTY
                     LHNDINEANLGNKNSPLKAALDVLRDIRNEIRILVDHGGINAESYKEELRNWYTPLNAF
                     LSIGPPVQRIKELRALIRAGILVLVGPEATVATSPINKDFKISSNRVKDSIFHAKNLID
                     ARLPSVNINQSKNILISNMLKAGLASEFKIATNNNYIFESGGLAVTPPPNRLIDKNGKV
                     NPNLYSFGIPTEGVHWVTAAGARPGVNSVTLLESDSIARDVLGCNITINNVYKQTIS"
     misc_feature    complement(5756..5771)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.85"
                     /tool="antismash"
     gene            5803..6612
                     /locus_tag="C6351_RS31465"
                     /old_locus_tag="C6351_31470"
     CDS             5803..6612
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016097814.1"
                     /locus_tag="C6351_RS31465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31470"
                     /product="isocitrate lyase/phosphoenolpyruvate mutase
                     family protein"
                     /protein_id="WP_223838112.1"
                     /sec_met_domain="PEP_mutase (E-value: 7.6e-65, bitscore:
                     208.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKLEFKEKIKLFRTLHDQNNPLMLPNAWDASSAKIFERNDFQAI
                     GTTSAGIAATLGYPDGEKIPLELMLNSISNISKNTKLPVSADIEGGYAANIFDLRKILN
                     ELEKFEVVGINIEDGRGTYLREINEQKVILDFIKAYSPHLFINARIDSFWLDIGDLKDR
                     IKDVIVRAEEYKKSGADCIFIPGVKDIETIKVLRENIELPINLLQSENLNSMQNIKTLK
                     IERVSLGSSAFRNILTNLDKISSTFKQGKLLHSNGNLTYQDLNLLMD"
     misc_feature    complement(6655..6669)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.5"
                     /tool="antismash"
     aSDomain        6905..7186
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C6351_RS31470_Pantocin_Microcin_RRE.1
                     "
                     /evalue="9.60E-30"
                     /identifier="RREFam017.1"
                     /label="C6351_RS31470"
                     /locus_tag="C6351_RS31470"
                     /protein_end="94"
                     /protein_start="0"
                     /score="93.6"
                     /tool="antismash"
                     /translation="MKPKFKETIPYFFLNKEIQIGEEEGLAGIIPDPTGSISFLINKLD
                     GQRNIPNIVQEVQKEFPDISSNEIIEAIKVLGNEGYLEDNSIVPELNDY"
     gene            6905..8008
                     /locus_tag="C6351_RS31470"
                     /old_locus_tag="C6351_31475"
     CDS             6905..8008
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000802791.1"
                     /locus_tag="C6351_RS31470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31475"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_000802788.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 6.2e-30,
                     bitscore: 93.6, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 9.3e-47, bitscore: 149.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPKFKETIPYFFLNKEIQIGEEEGLAGIIPDPTGSISFLINKLD
                     GQRNIPNIVQEVQKEFPDISSNEIIEAIKVLGNEGYLEDNSIVPELNDYILERYKANIN
                     YFSLFTKFGEDKYKIQEKILETPIALLGVGGLGTQVLYHLAALGFHNIKALDFDNIELS
                     NFNRQLLYSESDIGNSKVEMAKKRISQFNPNVDLQIINKKIESPQDVIEHIEGTELVIC
                     VADKPTLHIANWVNEGVVKCNLPMVYGGVLNTRGRFFSMIPSKTGCVQCHINYARQLND
                     KQDEQLEAMNNMEFTRNNAAISPNVAIVAGTIVNEALKILTQIAQPISLGKVMEVDFLT
                     LETNTVSSWEKMLDCPLCGQVVKSEVK"
     gene            8020..9252
                     /locus_tag="C6351_RS31475"
                     /old_locus_tag="C6351_31480"
     CDS             8020..9252
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000937089.1"
                     /locus_tag="C6351_RS31475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31480"
                     /product="MFS transporter"
                     /protein_id="WP_000937089.1"
                     /transl_table=11
                     /translation="MLPKVFLNKNYVILFSGMTISKLGMWFFTIAIPLIVYDLTHSPSK
                     MAFVLALELGAQVIFSLIGGALADQMSKKKIMIIGDYASALFVLVVPILFLSGYNSIIV
                     IYIAAFTLSALAAFHHPSFESAVPEILSKEDLIQGNSFFRLSETIITFLGPAVAGIAIA
                     LFGNSNVLLITSVAFFLSGTIFLFLKFRDFAEEEKKRPELVKPIVEGLRYVFGTKIILV
                     GSLVIFGINIGFGAVESLFMYYLKDYLGLSPINIGLIFSLQAIGPILAVYFASKFKHIP
                     RGNVIIYSGIVIGLAQMLLYFSQFSLVILVFCQIFIKGSVTLLAINWFTLRQETVPSKL
                     LGRVISSTRMVAFLALPFSAMIAGFLAESINVLSIFLVAGAFAIVSSIVGVSLGLFDRK
                     RLDKIQNDTAL"
     gene            9280..9759
                     /locus_tag="C6351_RS31480"
                     /old_locus_tag="C6351_31485"
     CDS             9280..9759
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014471322.1"
                     /locus_tag="C6351_RS31480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31485"
                     /product="DinB family protein"
                     /protein_id="WP_001033112.1"
                     /transl_table=11
                     /translation="MNKIELIIMNSNEVRRRSLNLWSSIPSEVLFHRVDSSSMTILEQV
                     RHVLEAEYLYLEILKTRKSLPYSDDEPNPFNTRDFSTIQDEVDFAKPYRKNFLDFIMGL
                     NEEDLENIKIDRSDVGYTRNLGDMLMRMAYHEAVHTGQLLRDMRALGLKRPHLWD"
     misc_feature    complement(9985..9998)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.4"
                     /tool="antismash"
     gene            10040..10273
                     /locus_tag="C6351_RS31485"
                     /old_locus_tag="C6351_31490"
     CDS             10040..10273
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001005923.1"
                     /locus_tag="C6351_RS31485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31490"
                     /product="hypothetical protein"
                     /protein_id="WP_001005923.1"
                     /transl_table=11
                     /translation="MNESVRKSEGELKKYEFTASELEMLFSGFYVAVRQLPENIGPKIY
                     EAIRCKSEDVLLKCLEESIRGSEEKKKEKSGF"
     gene            <10355..10688
                     /locus_tag="C6351_RS31490"
                     /old_locus_tag="C6351_31495"
                     /pseudo=""
     CDS             <10355..10688
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012259899.1"
                     /locus_tag="C6351_RS31490"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="C6351_31495"
                     /product="DDE-type integrase/transposase/recombinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KVKGQWI"
     gene            complement(10728..10877)
                     /locus_tag="C6351_RS32670"
     CDS             complement(10728..10877)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016097815.1"
                     /locus_tag="C6351_RS32670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000473828.1"
                     /transl_table=11
                     /translation="MFKKLVVGALATGISLIVSAFGTPFNNRMQVLAMLHSKFVEDSVL
                     VQKC"
     gene            11613..11942
                     /locus_tag="C6351_RS31500"
                     /old_locus_tag="C6351_31505"
     CDS             11613..11942
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566267.1"
                     /locus_tag="C6351_RS31500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31505"
                     /product="hypothetical protein"
                     /protein_id="WP_000566275.1"
                     /transl_table=11
                     /translation="MIDLLNKWMLESTGNFNIVVGITALLFLGSVIALIIIYKKIGKPD
                     ESTNAIYLKITSRMFTTQILMNAIFISLVGKDIENFRQIFILFEAFVFFIGAIYSFKLY
                     RQEYK"
     misc_feature    complement(11983..11996)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.67"
                     /tool="antismash"
     misc_feature    11984..11997
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.94"
                     /tool="antismash"
     gene            12020..13381
                     /locus_tag="C6351_RS31505"
                     /old_locus_tag="C6351_31510"
                     /pseudo=""
     CDS             12020..13381
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611143.1"
                     /locus_tag="C6351_RS31505"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31510"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTKFTSEDKMNAVIHYQDGSESIKDIAKSLGANHEVVRMWIKQFE
                     YHGILAFEKGYTTYSAQYKLDVLNYMFENGTSPNETAVIFNISSPGLIRKWRIQLHQKG
                     VDALKSKKKGRQSMTKDNQKSIKKQTQTEESVETLQAKLERLRMENAYLKKLNALVQNK
                     EKSPNKIRRK"
     gene            13594..13890
                     /locus_tag="C6351_RS31515"
                     /old_locus_tag="C6351_31520"
     CDS             13594..13890
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016098426.1"
                     /locus_tag="C6351_RS31515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31520"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_000918588.1"
                     /transl_table=11
                     /translation="MAGQIRMSPEELKSKAARYGQGANQIEDILSQLQNLQNELRGEWE
                     GRAFEGFDQQFNELKPKVQNFAQLLQEINMQLNKTAEAVASHDEELSRNFGLK"
     gene            14053..14328
                     /locus_tag="C6351_RS31520"
                     /old_locus_tag="C6351_31525"
     CDS             14053..14328
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000529644.1"
                     /locus_tag="C6351_RS31520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31525"
                     /product="TIGR04197 family type VII secretion effector"
                     /protein_id="WP_000529661.1"
                     /transl_table=11
                     /translation="MGQFQSNLQTATQIATKMESASDRIQSVTTRSITKATRTTLSVNF
                     KAQEANQQMLDLTKQFSAAFQQAVDNIHSVSNEFERMDNELHNTFR"
     gene            14369..14731
                     /locus_tag="C6351_RS31525"
                     /old_locus_tag="C6351_31530"
     CDS             14369..14731
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016121984.1"
                     /locus_tag="C6351_RS31525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31530"
                     /product="DUF3958 family protein"
                     /protein_id="WP_000076127.1"
                     /transl_table=11
                     /translation="MSQDIEKQINQVNQKLRSVFEEQDRNQSAIQAQEQAEADFYECRS
                     RNRRLFDRILGTWHGDREMSQFFMNTYQDAQHIERKVTFELENKKETLLKERRDLNDLE
                     NALSYQQQQLTREVNA"
     gene            14728..16368
                     /locus_tag="C6351_RS31530"
                     /old_locus_tag="C6351_31535"
     CDS             14728..16368
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000056148.1"
                     /locus_tag="C6351_RS31530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31535"
                     /product="T7SS effector LXG polymorphic toxin"
                     /protein_id="WP_097826161.1"
                     /transl_table=11
                     /translation="MSLNMYLGEVRSQTQSMNAVCTATIQGMEQAIQSIDAFAVDTVLQ
                     GQTYSSAKAFFVQTFRPLAQGIIYLCEELIRQNDAFPSDFQSQVAQADVIEHEILEQIR
                     EIDRMKTSMEAVNQAMPMPGMDAMVNLFIVMRQKLQEKLDHLYQFNQNSSNNYSTALQL
                     AASIAAGLAEVQSGKGFSPASGTFSMQGLNMEWTTSIQAITEERARQAANSIEEGEMCG
                     KLPEKSTGEKIWDGIVDGTGQAVSDTIDGIKALGDWETWENMGNAALHPIDTLSTMYNV
                     LSDSFINDVINGDAESRAKWGSYALTQVGLGLIGDKGLSKVSKVATTANLTKGMSRVTN
                     SATYRNAINVLNNFNLNIGNRFAYAGIGGSSLKSSFIDTYQTAKDKLSPYQYTKRTTDG
                     DIFVGKLYGEDVILKDVKVDEITYSKRTREEAEQLRKEFDRSVRKDFLNALVNDPVKLK
                     ELKKAGITDADIERMKRGNNPKGWQVHHNLPLDDGGTNDFGNLTLIQNHPYHKAITNTQ
                     RTLTRHLQEGDSVDVSWPIPKHNIYPKGE"
     gene            16393..16845
                     /locus_tag="C6351_RS31535"
                     /old_locus_tag="C6351_31540"
     CDS             16393..16845
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000265793.1"
                     /locus_tag="C6351_RS31535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31540"
                     /product="YrhA family protein"
                     /protein_id="WP_000265799.1"
                     /transl_table=11
                     /translation="MWKNLVLEIEKIEKSFNDKLNTPATDSEVQKLRERMKESYNVDLP
                     SEYEEFLKTVNGLDFNGLVLYGVDSYLLDTERDESICGLIETNEIWYENEFQKEYLFFG
                     DSNIAWFCKSLSDGTYLELDKPSGTVMNTYNDFNTMLEEALKITLL"
     gene            16864..17310
                     /locus_tag="C6351_RS31540"
                     /old_locus_tag="C6351_31545"
     CDS             16864..17310
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481683.1"
                     /locus_tag="C6351_RS31540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_31545"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_106082588.1"
                     /transl_table=11
                     /translation="MFNFLKEYVVADRSVRSKQKPIFYPIYQDEIDEAESLLQMELPKE
                     LKRFYQEISFGFFKSDTRTFFNRFMDPISVADFRLRQDIYEYNPNLDDDSLVFFEVTEL
                     NFLTIKFKEENELGQCPTYSEDEKIADSLEEFLIKMDENPDYYI"
ORIGIN
        1 gataaagatg ctttacctgc atgggcctct attatacaaa cgaacgaggg atatatagca
       61 cctcggaata gagtagagca aaaaatggta gaaatttggt cagaggtatt agggattgac
      121 tcctctgtca ttggggtaaa tgataatttt tttgatctag gtgggcactc tttaaaaatt
      181 atgagtactt tagtaaaaac attttctgaa ggttggaatg taactattaa agattacttt
      241 gaattaaaaa caattaataa tatagctaaa aaaattcaat atggatataa agtaaattca
      301 cattcagata cattagatat taaattgaca actcctccaa agaagctaaa gaaaacaaaa
      361 agacacgaat ttagtaataa tagcaaaata cttttaacag gtgctacagg attcttaggt
      421 attcacctac tagaacaact attggatact acagaatgta agatatattg tttagttcgt
      481 ggggaaaata aacaagaggc aaataatcgt ttattacaca tgttaaaatt ttattttaaa
      541 aataaatttg taaactatca atctttagta aatcaacgta tctttattgt acaaggtgat
      601 ttagctaaac aaaatatggg attagaaaac gaattatata aggagcttca tcaacaaata
      661 tcaactgtta ttcatgctgc agctttaaca aaacattttg gcgagtatag tgaatttgaa
      721 agagcaaatg tccaggcggt aaaagaactt cttgcatttg ttggtgatac taaggattta
      781 catcatatat ctacaactgg tgtagccgga caatttgtat taaatgaaac ggaaacaata
      841 tttaaagaaa gcgattttta tgtaaaacaa aattacaaag ataatgtgta tgtgaaaagt
      901 aaatttttgg cggaatatga aatattcaag gcaatattaa ggggaacaga tgctactatt
      961 tatagagtag gaaatcttac aaatagatat attgatggac aacatcaata taacttcacc
     1021 gaaaatgcat ttatgagcaa attaaaattt atattacaat atggtatcgt gacagatgta
     1081 ttattatcaa gtgaagttga gtttacacct gtagattatt gcagcaaaat tatcacaggg
     1141 tttgtaactt caaatgaaat acatgaaaat agcaaaaatt gcgtaaatca tatatacaat
     1201 catcttacgt taaatttaaa tgtacttgta aaattactaa attcaatggg atatccaatt
     1261 aaagtaattt ctgaaacaga gtatcaacaa tttattttag aactttctaa agataaaaag
     1321 aaacaggaag atattcaaaa cctcatgaca tttgaagaac caaaagataa ttgttataaa
     1381 ccaataaatc ttgattcgac tgaaactcaa aaaacactaa aattattagg tattcaatgg
     1441 cctattatta atagtgaata tatacaacaa attattaatt atatgacgag tgttactggt
     1501 agtaattctg ttgcaaagct ttttaaacaa agttacactt taaaaaactg aacagactca
     1561 tgagaaatga gaaattttaa aggaacacag ttaaaaaaat acgcaaaatt ttttagacaa
     1621 aatcactgaa ataggacaag cttttaggcg gaattatatg cataattatt gtgattctat
     1681 cctttataag gaaataattt ttagtcagca aacacatgta accttttgaa tattgggtaa
     1741 aagacaccct agtagagttt ttcatatcgt atgagacatt gctgtcgaaa aattgcaaac
     1801 agatgggaaa atacaacaag ctattatcca acaaagaaag aaataccccc atagaatacg
     1861 ttagagcgtt agatacatta gaagaattta atgaattgaa tttagactat gtagagacga
     1921 gtatgaagga ataataacaa tataacaagt actttttcag ctttctacgt tatataaggt
     1981 aaggggaaaa ctgtcatcga gattacaatt ttaagtggat tatctttttc tttatgggga
     2041 ataacatcgt taaacacgtt atatgaacaa gctacagtaa caaaaggaga tgtgtagcca
     2101 ttggaacagg gagtagcgga tatttaagtt gataattggg aacaggaaat gaataaatga
     2161 taggtgaagg attcttggga acccatggtt cttacaacag ataaaagatc ccttcgtttg
     2221 ttacgaaaag aatcttttat ctgttgtgtt tttttgttct tttgttcccg tattcctttt
     2281 cattttaggt ttcaaaaata tataaaatca attttaagac aaattactta cattaatatg
     2341 ctaatatcaa tagtagatat tttatcttaa attaatgaaa aagaaaggtg atactaatga
     2401 attcgacacc aattgattct gaaatcttta aggaccagtt tggtacaaaa caaatgagaa
     2461 caaatttttc agacgagaat ttaatacaat tgtggcttaa ttcagaagtt tccttagcaa
     2521 aagctgaagc taaattaggt attatacctc aaaatgcagc gactaatatt gcaaatgcag
     2581 ctgaccaaaa taaacttgat tttaataaga ttagagaagg aatgaaaaaa actggacacc
     2641 cctttgtagc attcctacat gagttcgaga gtttatgtga tgaagaatca cgtaagtaca
     2701 ttcattgggg agcaacaaca caagatataa ttgacacggg acttaccctg caaattaaag
     2761 gtgctcatga acttatttat aatcaaactc aagaaatatt aaagatatgt ttgagattaa
     2821 gccagcaata taagtcaaca gtaatgccag gcagaacgtt aggtcagcat gccttaccga
     2881 ttacttttgg atataagata tctatatggt cagatgaact tggtcgtcac ttagaaaggt
     2941 tacaacaagg tgcagaccga tatttagtgg ggcaactggg aggtgcagtt ggtactttag
     3001 cttcattagg agcgcaaggg ttagctgtta gaaaagagta tgtgaaaaat ttaaacctaa
     3061 ttgaaccctt agtatcttgg cacacgtcta gagaccgatt tgcagaattt agcatgattt
     3121 taaatatgat tggagcaact acagctaaag ttgcagaaga aataataagc cttcaaggaa
     3181 cagagattag agaagtagaa gaggggtacc attctggtaa agtaggaagt agcactatgc
     3241 cgcataaaag aaatcctatg acttgctctt atattgtggg attaactaaa atagtcaata
     3301 gaaaatcaac tttagctatt gacagtatga ttcagaaaca cgaaagagat gttacatttt
     3361 ggcaatctga atggtcttat atttcggaaa tttgcataac tttaagcggc gcattagaac
     3421 aacttaaaaa tgtcttaaca aacttaatag taaatgaaga acaaatgaaa aagaatcttt
     3481 ttcttaccaa aggtttaata gtatctgaga acgtaatgtt agaattgggg aagataattg
     3541 gtagaactac tgcccatgat ttattgtacg aattaacaat gagagctttt gaagaagaca
     3601 aagatttaaa agatatttta ttagaagaca atgaaattaa gaagtatttt agcgatgaag
     3661 agataaattc ccttactaat ccagaatcat acacagggtt gagtgaaaag tttgttgatg
     3721 atgtttataa caagtggttg agttatacat aaaaccaatt taagaccatt agctgaggaa
     3781 taattcctca gctaatggtc tgcttataca cattattaat tgtaatattg cagcctagaa
     3841 catctcttgc aattgaatcg gattcaagga gtgttacaga attaacccct ggtcgcgctc
     3901 ccgcagcagt tacccaatga acgccttctg ttggaattcc aaaggagtat aaattaggat
     3961 taactttacc gtttttatct attaatctat ttgggggggg agtcactgct aaacctccac
     4021 tttcaaaaat ataattattg ttcgttgcaa tcttaaattc tgaggctaga cctgctttta
     4081 acatatttga gattaaaata tttttacttt gatttatatt aactgagggt agtctagcat
     4141 caattaggtt ctttgcatga aatatcgaat ccttaacacg gttagagcta attttaaaat
     4201 ctttatttat aggtgaagta gctacagttg cttcaggtcc aactaaaact aaaattccgg
     4261 ctcttattaa tgccctcaat tctttgattc tttgaacagg agggccaatt gaaagaaatg
     4321 cgtttaaagg tgtataccaa ttgcgtaact cttctttata agattcagca tttattcctc
     4381 catgatcaac aagtattctt atttcgtttc ggatatccct taaaacatct aatgcggctt
     4441 ttagtggact gtttttatta cccaggtttg cttcgttaat atcattatgt aagtaagtat
     4501 ctaaccaatt atgaaagtct gttattgaat taaatttttt atcaccataa ggacaactaa
     4561 ttttgtgcca atcaaaaaat agttctgatt ttactccaaa gttgattaaa agatccttat
     4621 ggtattctat ggcacaatta acaaactcgt aaaggaactg acaagatttt tctattccat
     4681 agagattgcg aattaaagtt gtataataga tactttcaac ttccaatttt acgaaaggcc
     4741 atatctcttt tttaaagctt aggttatttt tatgttttaa ctgctcgata acttcatttt
     4801 ttagaaatag tgggatatgt ctttctgaag aacctttttg attttgtccc ctagagtgat
     4861 aaggtaagcc tcgcctagaa cctgcaatta ataaaggttc tttaccagag ggaatgtaat
     4921 ttaatttgtc attaatttct tcaaactttc catctctccc acttgttaaa agtgacatgt
     4981 aatcaaaaaa attaaggcct aatcccctta ttattacggg agttttaggt tctattgaat
     5041 ctaaattaac atctgctgga ttggatggtg ggaagtaatt taggttgtta ctattagcaa
     5101 actcaaagaa atgttcttca gctgaagtta atttctgatc tgagtgccca gttgtaaaga
     5161 taaccttttc agctttaatt ggtgttaaag acttagtaag aaataaagta taatcttcat
     5221 tgttcggata gagattaatt aatgtgtctt gaattaagtt aatcttaata tttgagggta
     5281 attcttcaag aatagtatta aatgaatctt taagataata gccgtataga gctcttgtag
     5341 ggtaagagtt aggttctaag gaataaattt cttctgtaat aacggtgggc atatctaaag
     5401 tgtcaatttt atcccttaat tcatttgccc attctaatag actaggccca ttaacgatag
     5461 gaccccgaca ctggacgcta tcatcagtaa ataaagttat ttgcgaagcc actgtattca
     5521 ttaaaagttg aggtgactgg tctgttctcc atacagctcc tcctggagga tgtggatcaa
     5581 ccaaaaaaaa ttcataagat tctgatttta attcagataa aatattagag actattcttt
     5641 caaatactga tatacctctt ggtcctaaac ctactatcgc gattttcata tactcacacc
     5701 tatcctttct gcaagatcta atttaatccg ttatgtaaaa caacataact agtaggtgca
     5761 aaaaaagtca agtgtaaaac taaaaaaata atttactaaa gggtgtttaa attggaattt
     5821 aaagagaaaa ttaagttatt tcgaacgtta catgatcaaa acaatccatt aatgcttcca
     5881 aatgcatggg atgcatcaag tgctaagatt tttgagagaa acgattttca agcgattggg
     5941 actactagtg ctggtatcgc agcaacctta ggttatccag atggcgagaa gattccttta
     6001 gagttaatgt taaattccat tagtaatatc tcgaaaaata ccaaacttcc tgtttcagct
     6061 gatattgaag gaggatatgc cgctaatatt tttgatttac gaaaaatatt aaacgagtta
     6121 gaaaaatttg aagtggtagg tataaatata gaggatggga gaggtacgta tttaagagaa
     6181 attaatgagc aaaaggtcat tttagacttt attaaagctt attcgcctca tcttttcata
     6241 aatgcaagaa ttgatagttt ttggctagat attggcgatt taaaagatcg tattaaggat
     6301 gtaatcgttc gtgcagaaga atataaaaaa tccggagcag attgtatttt tattcctgga
     6361 gttaaggata ttgagacaat aaaagtactt agagaaaata tagagttacc tataaatttg
     6421 cttcaaagtg aaaacttaaa ttccatgcaa aacataaaga cattaaaaat tgagagagtg
     6481 agtcttggat cttcagcttt taggaatatt ctaacaaacc ttgataagat aagcagcacc
     6541 tttaaacagg gaaaattatt acattcaaat ggaaacttaa cctatcaaga cttaaacttg
     6601 cttatggatt gattttttac aggtgaataa actactaaaa atagttattt ctataatttt
     6661 caaaaaaaag tttctcaacc tgaaactatc agactattat gtaatttctc ttttttgtgt
     6721 gttatgctag atttatcaaa tgtaggaggt gattacatat gatcgttaaa gtaaaaaaag
     6781 cttctaaaaa agtagttgct gctaatgcac ttactaatgt accaggttaa gtcattaaga
     6841 agaaccggat ttccggttct tcttaatttt ttaattaatc aattaattaa ggagatgtta
     6901 taaaatgaaa ccaaaattta aagaaactat cccttatttt ttcctaaata aagaaattca
     6961 aattggtgaa gaagaaggtt tagcaggtat aattccagac cctactggta gcatctcatt
     7021 tctaataaat aaattagatg gccagagaaa cattccaaac atcgttcaag aagtacaaaa
     7081 agaatttcct gatattagtt caaatgaaat tattgaggct ataaaagttt taggaaatga
     7141 aggttattta gaagataatt caattgtacc agaactcaat gattacatct tagaaagata
     7201 taaagcgaat ataaattatt tttcactatt cacgaaattc ggagaagata aatataaaat
     7261 tcaagaaaag attttagaaa cgcctattgc acttcttggt gtaggaggac ttggaacaca
     7321 agtactgtat catttggcag cattaggatt tcataatata aaagctctgg actttgataa
     7381 tattgaatta agtaatttta atagacagtt gctttattcg gaatcagata tagggaatag
     7441 taaggttgaa atggctaaaa agcgaatatc ccaattcaac cctaatgtgg atcttcaaat
     7501 tataaataag aaaatagagt cacctcaaga tgtgattgaa catattgaag gaactgagct
     7561 tgtgatatgt gttgcagata agccaacatt acatattgca aactgggtaa acgaaggtgt
     7621 ggttaaatgt aatctgccaa tggtttatgg tggagtatta aatactcgtg gtagattctt
     7681 ttctatgatt ccttctaaga caggttgtgt acaatgtcac attaattatg caagacaatt
     7741 aaacgataaa caagacgagc aattagaagc tatgaataac atggagttta ctagaaacaa
     7801 tgctgctata agtccaaacg tagctattgt agctggaaca attgttaatg aagcattaaa
     7861 aattttaacg cagattgcac aacctatttc tttagggaaa gttatggaag tggacttttt
     7921 aaccctagaa actaatactg tttcttcgtg ggaaaaaatg ttagattgtc ctctctgtgg
     7981 tcaagtagtt aaaagtgaag tgaagtgaag tgatttgata tgctacctaa agttttttta
     8041 aataagaatt atgtaatact tttttctggg atgacaataa gtaaattagg aatgtggttc
     8101 ttcactatag caattccatt aattgtttat gatttaaccc attctccaag taaaatggcc
     8161 ttcgtactag cattagagct tggagcccaa gttattttta gtttaatagg tggggcatta
     8221 gcagaccaaa tgtctaaaaa gaagataatg ataataggag actatgcttc agcgcttttt
     8281 gtactcgtag ttcctatact ttttttaagt ggttataaca gcataatagt tatatatatt
     8341 gccgctttta ccttatctgc tttagcagct tttcatcatc ctagttttga atctgcagtt
     8401 cctgaaatct tatctaaaga ggatcttatt caaggtaact cattctttag actaagcgaa
     8461 acgattatca cattcttggg acccgccgta gcggggattg caatagcgct ttttgggaat
     8521 tcgaatgttt tattaataac aagtgtggcc ttctttttat caggaacaat atttttattt
     8581 ttaaaattta gagattttgc tgaagaagag aagaaacgcc ctgaattagt aaaacctatt
     8641 gttgaaggac taagatatgt ctttggaacg aaaattatct tagttggttc tctagttatt
     8701 tttggtatta atataggatt tggagctgta gaatctcttt ttatgtatta cttgaaagat
     8761 tatctaggct tgagtcctat aaatattgga ttaatttttt cattacaggc aattggacca
     8821 attttggctg tttattttgc aagtaaattt aaacatattc caagaggaaa tgttattatt
     8881 tattcaggga ttgttatagg acttgcccag atgctcctgt acttctctca attcagctta
     8941 gtaattttag tattctgtca aatttttatt aaaggatcag ttactttatt agctattaat
     9001 tggtttacat tgcgacaaga gactgtacct agcaagttgc tcggaagagt tatcagttct
     9061 actagaatgg tagcattttt agctttacct tttagtgcta tgatagctgg ctttttggct
     9121 gagtcaataa atgttttgtc aatcttctta gttgcaggtg ctttcgcgat agtatcatca
     9181 atcgtaggtg taagtcttgg tttatttgat agaaaaagat tagataagat tcaaaatgat
     9241 acagcattgt aattagttaa gtgtaaaggg agttatttta tgaacaaaat tgaactaata
     9301 attatgaatt ctaatgaagt acgccggaga agtttaaatt tatggagttc tattcccagt
     9361 gaggttttat ttcatagggt tgattcatct tcaatgacta tattagaaca agtacggcat
     9421 gttttagaag ctgaatattt atatcttgaa attttaaaga ctagaaaaag tttgccctat
     9481 agcgatgatg aaccaaatcc tttcaataca cgcgattttt caaccattca agatgaggtt
     9541 gattttgcaa aaccttatcg aaaaaatttc ttagatttta taatgggatt aaatgaggaa
     9601 gatcttgaaa atataaaaat agatcgctca gatgtaggat atactagaaa ccttggagat
     9661 atgttaatga gaatggcgta tcatgaagcc gtacatacag ggcaattatt aagagatatg
     9721 agggctttag gtttaaaaag acctcatcta tgggattaaa ttaaaaatgg ttatccgtta
     9781 gcattctaaa taaatgtttc tatttctgac gagttataca tgttaaaata tataacatga
     9841 gtatgtaggg ggaagagtta tgagcactga agagttttta acagatattc atgagcatac
     9901 tccgagttat agacagataa aaatggaagc gttgagaaga tttcctaatg aacgtttgca
     9961 agttattgaa tatatataag aaaatgcaag tttatacgat tatttaatat gtttgttaga
    10021 tataacacag aatgctctgg tgaatgaatc tgtacgcaaa tcggaaggcg agttaaagaa
    10081 gtatgagttt acagcaagtg aattagaaat gttgtttagt ggattctatg ttgcagttag
    10141 gcaattgcct gagaacattg gacctaaaat ttatgaagct attcgatgca aaagtgaaga
    10201 cgtattattg aagtgtttag aagaatcaat aagagggtct gaagaaaaga aaaaagaaaa
    10261 aagcggattt taacattgaa atttatcgta caaagaattg acacttaaat ccctcacaaa
    10321 cgttacagaa agatataaga cctaagttga aagaaaagta aaaggtcaat ggatatagtt
    10381 atattgtgca gttgattcag agggtaatac aattgatttt tatctaagta aatcaagaga
    10441 taaaccagca gtcaagcgct ttttcaagaa agccttggct ttttcgcatg tttctaaacc
    10501 tcgtgtgata acagtagata agaaccctgc ctatcctgta gagattcaag tcatttaaaa
    10561 cagcaatctc tatattgagt ggtgtcgaat ctatgcatat gataaaaaac gggcaacttg
    10621 ttttaccgga caagtctgtc caaaatcaga aagaatttat tcctaaatgg tttggcttag
    10681 cttcataaga tagaaatgaa gagaaaattg ctattctatg tttccaacta acatttttgc
    10741 accagaaccg aatcttcaac gaatttacta tgtaacatgg ctaacacctg catcctatta
    10801 ttaaacggtg ttccaaatgc actaacaatt aagctaatac cagttgctaa tgctccaact
    10861 actaatttct tgaacataat aaatccccct taatattttt tataacttgc accctaaata
    10921 tatcactttt cttattttgt aaatgttttg aatttgtaga aaagtttatt tgaatcttat
    10981 taatattggt aattcatttt attaagtgga aaatagaggg atttttatag gtatgtaaaa
    11041 atacataata aatgaaccga atattatgat atactctcaa agagctgata caaaacttct
    11101 ttagattgga aaactaaatt cttatctacc caattgtggg ggcgccttat ggcgtctttt
    11161 ttttataaga aacctccaag cattcataca cttgagggtt tatcaattga aaggtagggc
    11221 tgtttggagt tccttaaatt aagaacaaag caggattatt cctaaaccaa ttaatagagc
    11281 tgcagcaaac gctggaattg gcacagggat ctcgatactt tctacaacta agaagtattg
    11341 tccacttact actttaaaac aaactaattg cattaattaa gagttttagt gcactactcc
    11401 ttggaagttg atcttgtagc gctctttctc gtaattcact atgttttcca aagaaaatag
    11461 tgaaaggcaa ggcgatgaat acatttacaa aatgacaaaa ctgtaagaat acacgaatgt
    11521 ttgtaagaaa gttcgatgtt ttcctttttc tttttttatt atagtgaaaa agaaggacga
    11581 aatattctct tatgtaggaa aggaagataa taatgattga tctattaaat aaatggatgt
    11641 tagaaagtac aggcaatttc aatatcgttg taggaattac agcacttcta tttttgggtt
    11701 cagtaattgc acttattatt atttacaaaa aaattggtaa accagatgaa agcacaaatg
    11761 ctatttattt aaaaattact tctcgtatgt ttactactca aattctaatg aatgctatat
    11821 ttatttcttt agttggtaaa gatattgaga atttccgtca aatctttata ttatttgaag
    11881 cttttgtatt ttttattgga gctatttatt cgtttaaatt atatagacag gaatataaat
    11941 aacttacttg caagaaacaa taaaaaaact gcaccccaat tgttagacac agtctaacaa
    12001 ttggaggtgt agttttttta tgactaaatt tacttcagaa gacaaaatga atgcagtaat
    12061 acattatcaa gatggaagtg agagtataaa agatattgcg aaatcattgg gagcgaatca
    12121 cgaagtggtt cgcatgtgga taaaacaatt tgaatatcat ggaatcctgg cctttgaaaa
    12181 aggctataca acgtattctg cacagtataa actagacgta ctaaattata tgttcgaaaa
    12241 tgggacgtct ccaaacgaaa cggcagtcat ttttaatatt tcttcacctg gacttattag
    12301 aaaatggcgt attcagctac atcaaaaagg agtagacgcc cttaaatcga agaaaaaggg
    12361 gcgtcaatct atgactaagg acaatcaaaa atcaattaag aaacaaacac aaacagaaga
    12421 gtcagtagaa acattacaag ctaaattgga gcgtttgcgt atggagaatg cttatttaaa
    12481 aaagttgaat gccttagttc aaaacaagga aaaatcacca aacaagataa ggcgcaagta
    12541 atctatgaac taaggaaagc atttccggtg caggcacttt taaaattagc agaactccca
    12601 cgaagtacat attattactg gatacagaat tctaatcgac cagataaaga taaagagcta
    12661 aagatcctta attcaaaaca tttacgatga acaccaaggt cgttatggat atcgccgtat
    12721 tcgcgatgag ttaatgaacc aaggacacaa aatcaaccat aaaaaagttc aacgaattat
    12781 gaaagagtta ggtttaaaga gtctagttcg tatgaaaaaa tatcgctcgt ataaaggaca
    12841 agtaggtaag attgcgccaa atattttaga acgtaatttt aaagctgaaa agccgaacga
    12901 aaaatgggtt acagacataa cagaatttaa attatgtggc gagaagctct acttatcacc
    12961 gatgttagat ctatttaatg gagagataat cgcttataca attgattcaa gaccaaccta
    13021 ttcacttgta tcgaagatgt tggagaagtc ttttcaacaa ttgacagaag aagacgaact
    13081 ccttattcac tctgatcaag gctggcatta tcaaatgaag aagtatcgtc acgccctaaa
    13141 ggaacgcaag attacgcaaa gtatatctcg taaagggaac tgttacgata atgcggttat
    13201 tgaaagtttc tttggtatta tgaaatctga atttctttat ctaaaagatt ttgaaagcat
    13261 agaacacttt aaacaagaat ttgaaaaata tatcgattat tataatcaca aaagaattaa
    13321 ggcaaaacta aaaggcatga gtccggtaca atatcgaact catgccctaa aggctgccta
    13381 atgaaacgac ctgtctaact ttatggggtc agttcacctt ttggtggtct tttttgcata
    13441 aaatcttgta aagcaagaaa aagtagaata ttaatattct aatattcaat agaaagataa
    13501 agtgtttaaa agttcaaaat aatacattat aatctattta gtaaaattaa ccaaaatata
    13561 ttttgcttat tatgtattaa aggggaaatg aaaatggctg gacaaattcg tatgtcacca
    13621 gaggagctta aatcaaaagc ggctcgatat ggacaaggtg caaatcaaat tgaggacatt
    13681 ttaagtcaac tacaaaactt gcaaaatgaa ttaagaggag aatgggaagg tcgtgctttc
    13741 gaaggttttg atcaacagtt caatgaatta aagccaaaag tacaaaactt tgcacagcta
    13801 ttacaagaaa ttaatatgca gctgaataaa actgcagaag ctgttgcttc tcatgatgaa
    13861 gaattatcac gtaatttcgg tttgaaataa aaattgtcat aatctatata acaagcattt
    13921 caaatgagcc atacagctta tattgtatgg ctcatttgat tgcatgccta gagcgagtga
    13981 tattgatagg gatatatatt ttatgagatt tctttgatgc gtttggaaaa cttatagaaa
    14041 gggtttgaaa gaatgggaca atttcaaagt aatttacaaa cagcaacgca aattgctacg
    14101 aaaatggaat cagcctctga taggattcaa agtgtaacaa ctcgttctat aacaaaggcg
    14161 acgcgtacaa cattatctgt taacttcaaa gcacaagaag cgaatcaaca aatgttagac
    14221 ttgacgaaac aattttccgc tgcctttcaa caagcggttg ataatattca ttcggtatct
    14281 aatgaatttg agagaatgga taacgaactt cacaatactt ttcgctaatg tgacaaccta
    14341 cgtaaagtaa aatagtagga ggaaaaagat gagtcaagat attgaaaaac aaattaatca
    14401 agtaaatcaa aagttacgaa gtgtatttga agaacaagac cgaaatcaat ctgcgattca
    14461 agctcaagaa caagcggaag cagattttta tgaatgtaga agtcgaaatc gtcgtttgtt
    14521 tgatcgaatt ttaggaactt ggcatggtga tagagaaatg tcccagtttt ttatgaatac
    14581 gtatcaagat gcacaacata ttgaacgaaa agtcacattt gaattggaaa acaaaaaaga
    14641 aacgttgctt aaagaaagac gagaccttaa tgatttagaa aacgcccttt cctatcaaca
    14701 acaacaatta acaagggagg tcaatgcatg agtttaaata tgtatttggg agaggtacga
    14761 agccaaactc aaagcatgaa tgctgtatgt accgctacta ttcaaggtat ggaacaagcc
    14821 attcagtcga ttgacgcttt tgcagttgat actgttttac aagggcaaac atatagtagt
    14881 gcaaaagcat tttttgtaca aacctttcga cctttggcac aaggaatcat ttatttgtgt
    14941 gaagaattaa tccgtcaaaa tgatgctttt ccaagtgact ttcaatcaca ggtagctcag
    15001 gcagatgtaa ttgaacacga gatattagaa caaattcggg aaattgaccg aatgaaaaca
    15061 agtatggaag ctgtcaatca agctatgcca atgccgggta tggatgccat ggtaaatctt
    15121 tttattgtta tgaggcaaaa actgcaagaa aagctggatc atttgtatca attcaatcag
    15181 aactctagta ataattatag tacagcactt caattagcag ctagtattgc tgcaggtctt
    15241 gcggaagttc aaagtgggaa agggtttagt cctgcaagtg gtacatttag tatgcaaggg
    15301 ttgaatatgg aatggacaac ttcaattcaa gcgattacag aagagagggc acgacaagct
    15361 gccaattcaa ttgaagaagg tgaaatgtgt ggtaagctac ctgaaaaatc tactggtgaa
    15421 aaaatttggg acggtattgt agatggtacg ggacaagcag ttagcgatac aatagacgga
    15481 ataaaagctt taggagattg ggaaacgtgg gaaaacatgg ggaacgctgc tttgcaccct
    15541 attgataccc tcagtacgat gtataatgta ttgtcagatt catttattaa tgatgtaata
    15601 aatggagatg ctgaaagtcg tgctaaatgg ggaagttatg ctttaacaca agttggatta
    15661 ggacttattg gtgataaagg attaagtaaa gtatcgaagg tagcaactac tgcaaatcta
    15721 acaaaaggta tgtccagagt aactaattct gctacatata gaaatgcaat aaacgtatta
    15781 aataatttta atttaaacat tggaaaccgt tttgcttatg ctggtattgg gggaagttct
    15841 ttaaaatcta gctttattga tacttatcaa acagctaagg ataagctatc accttatcaa
    15901 tatactaaaa ggactacgga tggtgacatt tttgttggta aattatatgg agaagatgta
    15961 attcttaaag atgttaaagt tgatgaaatt acttactcta agagaactcg agaagaagct
    16021 gaacaacttc ggaaggaatt tgataggagt gtgagaaaag attttcttaa tgcattggta
    16081 aatgatcctg ttaaactgaa agaactcaaa aaagcgggaa taacagatgc tgatatagaa
    16141 aggatgaaaa gaggaaacaa tccaaaaggg tggcaagtac atcataacct ccctttagat
    16201 gatggaggaa caaacgattt tggaaattta acattaatac aaaatcatcc atatcataaa
    16261 gctataacta atacacaacg tacgttaact agacacttac aagagggaga tagtgtagac
    16321 gtaagctggc ctataccaaa acataacatc taccctaagg gagaataaat aaacttagaa
    16381 agggattttt atatgtggaa aaatctggtt ttagaaattg aaaaaataga gaaaagtttt
    16441 aatgataaac tgaatacacc agcaacagat agtgaagttc agaaattaag agaacgcatg
    16501 aaagagagtt ataatgttga cctaccgagt gaatatgagg agtttcttaa aactgtaaat
    16561 ggattagatt ttaacgggct agtactttat ggagttgact cttatttgtt agatacagaa
    16621 agggacgaat caatttgcgg gcttatagaa accaatgaga tttggtatga aaatgaattt
    16681 caaaaagagt atcttttctt tggcgattca aatattgcgt ggttttgtaa gagcttatca
    16741 gacggtactt atttagaact tgataaacca tctggtacgg taatgaacac atataatgat
    16801 tttaatacaa tgcttgagga agcgttaaaa ataacccttc tttaataggg ggtattaaaa
    16861 attatgttta attttttaaa agaatatgtt gtagcagaca gaagtgtccg ttctaaacaa
    16921 aaacctattt tctatcctat atatcaagat gagatagatg aggcagaaag cttattacaa
    16981 atggaacttc caaaagaact gaaacgcttt tatcaagaaa taagttttgg tttttttaag
    17041 tctgatacaa gaacgttttt caacagattt atggacccga tttcagttgc agatttccgt
    17101 ttaaggcaag atatttatga atataatcca aacctagatg atgattcatt agtgtttttt
    17161 gaagtaacag aacttaactt tttaacaatt aaatttaaag aggaaaatga attaggtcaa
    17221 tgtcctactt actctgaaga tgagaaaata gcggattctt tagaagaatt tttaattaaa
    17281 atggatgaaa atcctgacta ttatatttaa tctttttaag acttgcatta aggtgtagca
    17341 tttgaaaaat atctaatcat gagtaaaaaa gcttatgtat aatgaagtga acccgaatag
    17401 tggtacatga aaaaaacacc tcctgaattc gcatactaag tatgcaaatt cattggaggt
    17461 gtttttcgtt tgaagacaag agttcattac ccagaagaag taaagtgga
//
