LOCUS       NZ_PVRL01000013        25239 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  Bacillus thuringiensis strain NMTD81
            NODE_13_length_159018_cov_11.0582, whole genome shotgun sequence.
ACCESSION   NZ_PVRL01000013
VERSION     NZ_PVRL01000013.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus thuringiensis
  ORGANISM  Bacillus thuringiensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 159018)
  AUTHORS   Borriss,R., Lasch,P., Wu,L., W,H. and Gao,X.
  TITLE     Genotypic and phenotypic analysis of antagonistic Bacillus spp.
            isolated from rhizosphere soil of plants in Tibet
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 159018)
  AUTHORS   Borriss,R., Lasch,P., Wu,L., W,H. and Gao,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) UG, NordReet, Marienstr. 27a, Greifswald
            17489, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: A5 v. A5-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 14.5x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002998815.1-RS_2024_05_21
            Annotation Date                   :: 05/21/2024 01:45:19
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,177
            CDSs (total)                      :: 6,068
            Genes (coding)                    :: 5,840
            CDSs (with protein)               :: 5,840
            Genes (RNA)                       :: 109
            rRNAs                             :: 11, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 1 (5S, 23S)
            partial rRNAs                     :: 6, 5 (16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 228
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 228
            Pseudo Genes (frameshifted)       :: 100 of 228
            Pseudo Genes (incomplete)         :: 142 of 228
            Pseudo Genes (internal stop)      :: 67 of 228
            Pseudo Genes (multiple problems)  :: 63 of 228
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:59:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 48836
            Orig. end                         :: 74075
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVRL01000013.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            296..1222
                     /gene="bla"
                     /locus_tag="C6351_RS23650"
                     /old_locus_tag="C6351_23660"
     CDS             296..1222
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002101021.1"
                     /locus_tag="C6351_RS23650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23660"
                     /product="class A beta-lactamase Bla1"
                     /protein_id="WP_142399146.1"
                     /transl_table=11
                     /translation="MILKNKRMLKIGICVGILGLSITSLEAFTGGALQVEAKEKTGQVK
                     HKNQATHKEFSQLEKKFDARLGVYAIDTGTNQTISYRPNERFAFASTYKALAAGVLLQQ
                     NSIDTLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGG
                     PKGYEKTLRHMGDRITMSDRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEK
                     RKILTEWMKGNATGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPIIIAIL
                     SSKDEKEATYDNQLIAEATEVIVKALR"
     gene            1483..2325
                     /locus_tag="C6351_RS23655"
                     /old_locus_tag="C6351_23665"
     CDS             1483..2325
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="C6351_RS23655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23665"
                     /product="metallophosphoesterase"
                     /protein_id="WP_106082178.1"
                     /sec_met_domain="Metallophos_2 (E-value: 2.5e-09, bitscore:
                     30.7, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKINRIVMIICILVGFTIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKIKSIDPDIIAITGDLIDSKSYDAEVSMQLIREI
                     VKKYPVYFVTGNHEQWSGKYNNLEKELKKYDVNVLRNEHVGIRKGEQEINLLGIDDPEF
                     VTGNRDEGNIIIDEIKKAKIEMQPDKYNVLLSHRPEFIKEYTNERLDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGVLPKYTAGLYVEQNTLMVVSRGLGNSIIPQRILNRPEIVVVQLN"
     gene            2540..2791
                     /locus_tag="C6351_RS23660"
                     /old_locus_tag="C6351_23670"
     CDS             2540..2791
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="C6351_RS23660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23670"
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     gene            2979..3704
                     /locus_tag="C6351_RS23665"
                     /old_locus_tag="C6351_23675"
     CDS             2979..3704
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001187059.1"
                     /locus_tag="C6351_RS23665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23675"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001187074.1"
                     /transl_table=11
                     /translation="MQQPSIILRTVSKSFGKKEVLHNLSLQVEKAEIFGFVGPSGSGKT
                     TLIKMIAGINEATKGEVLVNNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKSKKTRIAEVFELVQLSQYMKKQVQQFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVAVGTTEELKK
                     RVSSGRIEDVFLLEEVVPS"
     gene            3701..4720
                     /locus_tag="C6351_RS23670"
                     /old_locus_tag="C6351_23680"
     CDS             3701..4720
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="C6351_RS23670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23680"
                     /product="ABC transporter permease"
                     /protein_id="WP_001266715.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PQIAVVDMPAQIVKMMKNQEASIYEYSKEKAISELEKQKVDAVFRIENGKMKLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVAGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPLESMNKW
                     LQMLGKVFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSILFAVGNVFALKKHRKI"
     gene            4745..5398
                     /locus_tag="C6351_RS23675"
                     /old_locus_tag="C6351_23685"
     CDS             4745..5398
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168192.1"
                     /locus_tag="C6351_RS23675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23685"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_001168192.1"
                     /transl_table=11
                     /translation="MQKDWLEELIAATNTDKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQTFAKEIFKSEYESYEGLL
                     RVVIHNRFKFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKFQEEGE
                     IIEIPPSSVLRLTLSAVLGLLLTRFLLLPEEKWNDEAEIENTIQFILYGLTPRI"
     gene            complement(5520..5819)
                     /locus_tag="C6351_RS23680"
                     /old_locus_tag="C6351_23690"
     CDS             complement(5520..5819)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="C6351_RS23680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23690"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_063224864.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLALSIMFLGTSAQAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDKNNNWAWLGLLGLAGLLGLRRRDKETR"
     gene            6054..7022
                     /locus_tag="C6351_RS23685"
                     /old_locus_tag="C6351_23695"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="C6351_RS23685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23695"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_106082179.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRLVQPSTREDVTEKMEQFSNDFLQMIPDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGAGLFGGAVVKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHNKNMKELVSFQSDNKYLFMAYNQVKQKELGRIIANHKNEKIEVVFE
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="C6351_RS23690"
                     /old_locus_tag="C6351_23700"
     CDS             7239..8384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="C6351_RS23690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23700"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397282.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 5.2e-41, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.3e-27, bitscore:
                     89.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.1e-58, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGVEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="C6351_RS23695"
                     /old_locus_tag="C6351_23705"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="C6351_RS23695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23705"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_106082180.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 7.7e-12,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1e-07, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 8.5e-08, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1.4e-10, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKIGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITNLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDEVFKEGIYTTGFVTKQLVKK"
     gene            9764..9979
                     /locus_tag="C6351_RS23700"
                     /old_locus_tag="C6351_23710"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="C6351_RS23700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23710"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_106082181.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EVGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="C6351_RS23705"
                     /old_locus_tag="C6351_23715"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="C6351_RS23705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23715"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775428.1"
                     /sec_met_domain="HMGL-like (E-value: 6.4e-49, bitscore:
                     160.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISATAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="C6351_RS23710"
                     /old_locus_tag="C6351_23720"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 1.5e-75. Score:
                     245.6. Matches aSDomain:
                     nrpspksdomains_C6351_RS23710_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="C6351_RS23710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23720"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_000939799.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLNRARQANSLSLALLDELQTILTQI
                     SEDSSARVVILTGAGEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRIEGLQAFKEKRKPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6351_RS23710_ECH.1"
                     /evalue="1.50E-75"
                     /label="C6351_RS23710_ECH.1"
                     /locus_tag="C6351_RS23710"
                     /protein_end="254"
                     /protein_start="14"
                     /score="245.6"
                     /tool="antismash"
                     /translation="HVVKISLNRARQANSLSLALLDELQTILTQISEDSSARVVILTGA
                     GEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRIEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="C6351_RS23715"
                     /old_locus_tag="C6351_23725"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="C6351_RS23715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23725"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_063675383.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQLFTDRKHPVYPV"
     gene            13299..15239
                     /locus_tag="C6351_RS23720"
                     /old_locus_tag="C6351_23730"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 4e-82.
                     Score: 267.9. Matches aSDomain:
                     nrpspksdomains_C6351_RS23720_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="C6351_RS23720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23730"
                     /product="AMP-binding protein"
                     /protein_id="WP_000806483.1"
                     /sec_met_domain="AMP-binding (E-value: 1.4e-89, bitscore:
                     293.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDKYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDEVKGEVCHCFVVLRDHVTFTGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13596..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C6351_RS23720_AMP-binding.1"
                     /evalue="4.00E-82"
                     /label="C6351_RS23720_AMP-binding.1"
                     /locus_tag="C6351_RS23720"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDKYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6351_RS23720_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="C6351_RS23720"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C6351_RS23720_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="C6351_RS23720"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15557..15928)
                     /locus_tag="C6351_RS23730"
                     /old_locus_tag="C6351_23740"
     CDS             complement(15557..15928)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C6351_RS23730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C6351_23740"
                     /product="hypothetical protein"
                     /protein_id="WP_042992790.1"
                     /transl_table=11
                     /translation="MIAGVLRKSIVVMIGGNLKKSIIVMMIGVLRKSIVMMIGGNLKKS
                     VIVTMIGGNLKKSVIVMMIGVLNEISVVVNVSLFVAIVKEKIGNFFNVNVKERIWLLEP
                     IGLFRKVNPTPTSLLSLNF"
     gene            16527..16883
                     /locus_tag="C6351_RS23735"
                     /old_locus_tag="C6351_23745"
     CDS             16527..16883
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="C6351_RS23735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23745"
                     /product="hypothetical protein"
                     /protein_id="WP_000535572.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVSSVSCDLVRLAAIPGSVGVIISICKIEAIFPPVTTVT
                     ADFDFNGIDVANKA"
     misc_feature    16898..16913
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            16989..17522
                     /locus_tag="C6351_RS23740"
                     /old_locus_tag="C6351_23750"
     CDS             16989..17522
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002007691.1"
                     /locus_tag="C6351_RS23740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23750"
                     /product="GNAT family protein"
                     /protein_id="WP_000990084.1"
                     /transl_table=11
                     /translation="MMYERSKEVIKLESFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTLAFKVVDEVTSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFDELKLHRVTLGVYDFNTSAIFCYEKIGFVKEGLLRESKRVGETYW
                     NLWEMSMLEYEWKK"
     gene            complement(17794..18402)
                     /locus_tag="C6351_RS23745"
                     /old_locus_tag="C6351_23755"
     CDS             complement(17794..18402)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807974.1"
                     /locus_tag="C6351_RS23745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23755"
                     /product="hypothetical protein"
                     /protein_id="WP_106082182.1"
                     /transl_table=11
                     /translation="MTEIKVGLTQFLDFTLKGSTAKTNFIKNLKSQPEYQPAFDYWKQL
                     RETVIKFHQNKLPFECFETLVQTVDQKKKQNYIDVIKQFKKFIKNKDISWFDPGKSHWK
                     SDDLIVRSSPELGLFINNEPHLIKLFFKGKKERIDKYNINSTLTLLNESTFSNERNDVN
                     YTVLNIQKNRMYTNNSINNNHLVALKSEANQFCYIWNNL"
     gene            complement(19011..19148)
                     /locus_tag="C6351_RS23750"
                     /old_locus_tag="C6351_23760"
     CDS             complement(19011..19148)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="C6351_RS23750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23760"
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     gene            <19330..19419
                     /locus_tag="C6351_RS23755"
                     /old_locus_tag="C6351_23765"
                     /pseudo=""
     CDS             <19330..19419
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288863.1"
                     /locus_tag="C6351_RS23755"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23765"
                     /product="DNA damage-inducible protein DinB"
                     /pseudo=""
                     /transl_table=11
                     /translation="YEIHHIGQLSIWARQLNLQPVSANLIGRG"
     gene            complement(19481..20497)
                     /locus_tag="C6351_RS23760"
                     /old_locus_tag="C6351_23770"
     CDS             complement(19481..20497)
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="C6351_RS23760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23770"
                     /product="serine hydrolase"
                     /protein_id="WP_106082183.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSAALSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGNEDNFTVLMNKKAKELKLLQPSPFLNS
                     TGNNNDTNKQSTTTAIDAAKLAARLIKDFPDVLNITKLTSYQFSFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLEDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSYSALQAFKDTLTSWTILLQFKNLIIQTIMIFLIITTLMFLHIRQKKSEDFN"
     gene            complement(20672..21829)
                     /locus_tag="C6351_RS23765"
                     /old_locus_tag="C6351_23775"
     CDS             complement(20672..21829)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001243314.1"
                     /locus_tag="C6351_RS23765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23775"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_001243314.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGVKESLWMMIVSYLFLFSIFSSYLYIFYRHERKLYYET
                     CIKKMIEEIRYIANGNFNHKVSVVNHNYLEELAIGVNEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKG"
     gene            complement(21819..22514)
                     /locus_tag="C6351_RS23770"
                     /old_locus_tag="C6351_23780"
     CDS             complement(21819..22514)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="C6351_RS23770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23780"
                     /product="response regulator transcription factor"
                     /protein_id="WP_001038808.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKFIHTV
                     WGVGYKIEK"
     gene            22707..23315
                     /gene="yqeK"
                     /locus_tag="C6351_RS23775"
                     /old_locus_tag="C6351_23785"
     CDS             22707..23315
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000965880.1"
                     /locus_tag="C6351_RS23775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23785"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_017763190.1"
                     /transl_table=11
                     /translation="MLYNDIYSFAPTGKIDNDIKDFLLKYNKEFTYKHSIRVANEAKKI
                     AEKFHVDKEKAAIAGYLHDISGIFPNEERIAVAEEFGVEIEEAERKFPMIIHQKLSRVI
                     AKEIFKVEDEDVLDAICCHTTLRKHPTKMDLVLFVADKIEWDQKGTPPYLIEIKKGLEK
                     SLEKAAFVYISYLWERKDTLKVIHPWLEEAYWYLKRIVQ"
     gene            23329..>23700
                     /locus_tag="C6351_RS23780"
                     /old_locus_tag="C6351_23790"
                     /pseudo=""
     CDS             23329..>23700
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002110027.1"
                     /locus_tag="C6351_RS23780"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23790"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQLKEYMNQTFPGVTLVPYLYSQWGNHLYFDFGKDKYQIVEGTDD
                     LNMEYFSQLYTYNNFLFEDIFSKEDVVFVVTNVYRFKKENTKTPQKINVYNKYIKKRDL
                     RFHIRQETLPFLFEDEEADL"
     misc_feature    complement(23766..23780)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.69"
                     /tool="antismash"
     misc_feature    23768..23782
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            <23842..24147
                     /locus_tag="C6351_RS23785"
                     /pseudo=""
     CDS             <23842..24147
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002156408.1"
                     /locus_tag="C6351_RS23785"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF3885 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LYCTYQFSLKCLAEDIKYESLIQAANHEDFSILYPRFGRKKEISY
                     PDVFLINATKDIVMFMYDDRGCEVIAKNKEIIRDLYKKYKEWIPDYERESIDNLFK"
     gene            24144..24881
                     /locus_tag="C6351_RS23790"
                     /old_locus_tag="C6351_23800"
     CDS             24144..24881
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129475.1"
                     /locus_tag="C6351_RS23790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C6351_23800"
                     /product="S-adenosylhomocysteine nucleosidase"
                     /protein_id="WP_002082744.1"
                     /transl_table=11
                     /translation="MTIGEVKRVMKRIAIVSAWEPELTYLHQHYPSERVEKRAAWEFHF
                     HTINELEIISVVTGVGKVSCASCVQLLISEFQPDELFMTGICGSLSNKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRLYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEHLIAFLRVYEINVVNNR"
ORIGIN
        1 ttagatgtat actttgattt aaaacagcaa cgcatacatg gtgaagctac tagtacaagt
       61 agttctaagc aaaattagag tacttttctc agggaaagac cctgttcata taaagccatt
      121 tataagtaaa aaaatgaaat atgaaataag agatagaggc gtcgtagcta ctatctctta
      181 ttttgttaat aactctcata ctagctataa tttttttagt ttatggaaca aatttggttc
      241 ggtgattgtc tattatgtgt acgtataaaa aggtgctaaa aatttggaag gaatgatgat
      301 tttgaaaaat aagaggatgc taaaaatagg aatatgcgtt ggtatattag gtttaagtat
      361 tacaagccta gaagctttta caggaggggc actgcaagtt gaagcgaaag aaaagactgg
      421 acaagtgaaa cataaaaatc aggcgacgca taaagagttc tctcaacttg agaaaaaatt
      481 tgatgctcga ttaggtgtat atgcgattga tactggtaca aatcaaacaa tctcttatcg
      541 acctaacgaa agatttgcct tcgcatcaac ctacaaggct ttagctgcag gagtattact
      601 acagcaaaac tcaattgata cattaaatga agtaatcaca tttacgaaag aagacttagt
      661 ggattattca cctgttacag agaaacatgt agatactgga atgaaactag gagaaattgc
      721 tgaggctgct gttcgttcaa gtgataatac tgcagggaac attttattta ataaaatagg
      781 cggaccgaaa ggatatgaaa aaacgcttag gcatatgggg gatcggatta ctatgtctga
      841 tcgctttgaa acagaattaa acgaagctat tccaggagac attcgtgaca ctagtacagc
      901 gaaagctatt gctacgaatc ttaaagcttt tacggtcgga aatgcacttc cagctgaaaa
      961 acgtaaaatt cttacagagt ggatgaaagg aaatgctaca ggggacaaac ttattcgtgc
     1021 aggcgtacca actgactggg tagttggaga taaatcaggt gctggtagtt acgggacaag
     1081 aaatgatatt gctatcgttt ggcctccaaa tagagcacca attatcatcg caattttatc
     1141 tagtaaagat gagaaagagg ctacctatga taatcaactc attgcagagg caactgaagt
     1201 tatagttaag gctcttaggt aatagtattt tagttttcgc atttttaaca taaaagtatt
     1261 aaaagtgtaa agttagaaaa cgactctttt cgtgtgataa gagtcgtttt tgtgttctta
     1321 ttattaaaaa ggtaaaagta aaaatataac gaatatatat gacgtatctc atatgaaatt
     1381 ttatgtactg tattatttta ttaatttaaa taaatttcaa gaaagtataa tataattcag
     1441 ttagcatata gaagtgtttg atgagaatat aaaggagaaa atatgaaaaa aaagattaat
     1501 agaatcgtaa tgattatttg tatattagta ggttttacaa tctttttata tttacagaac
     1561 aatttaataa gtataactga ggttaaaata acctctagta aaataccatc ctcttttaaa
     1621 gggtataaaa ttctacaaat ttcagactta cacaataaaa aatttggcga taatcaagat
     1681 gtgttaattc aaaaaataaa aagtatagac ccagatatta ttgcgattac gggtgattta
     1741 attgacagta aatcatacga tgcagaagtt agtatgcaat taatacgaga aattgtaaag
     1801 aagtatcctg tatattttgt gacaggaaac catgaacaat ggtctggaaa gtataacaat
     1861 ttagaaaaag agttgaagaa atatgatgtc aatgttttaa ggaatgaaca tgtaggcatt
     1921 cgaaagggtg agcaagaaat aaacttgcta ggtattgatg atccagagtt tgttactgga
     1981 aaccgtgatg aaggaaatat tataatagat gaaattaaaa aagcgaaaat tgaaatgcag
     2041 ccagataaat ataatgtatt attatcccat cggcctgaat ttataaagga atatacgaat
     2101 gagaggttgg atttggtttt atcgggacat gctcatggag ggcaagttag attgccattt
     2161 atcggtggat tagttgcgcc aaatcaaggt gttttaccta aatatacagc aggtttatat
     2221 gtagaacaaa atacattaat ggtagtgagt agaggattag gaaatagtat cattccgcaa
     2281 agaattttga ataggccaga gattgtagtc gtgcagctaa attaagctgt acgatttttt
     2341 tatacaataa tgagtaaagg ggctttatgt attttgcagg agttaacatt acaattttgt
     2401 taaaaatttt ctacgttaca taaagtaaca aaatttgacc ctgagtgttt gttatagtgt
     2461 aaataatcaa aaaacttaaa atttgtcgag tgaaaattgt gataagtaat tcatgtaaaa
     2521 aacttaaagg ggtgtacaca tgcataaaga atatgaaatt gaagaataca cggcgattga
     2581 ggaacaaata cattattatt gtaaatgttt attagtaagt catcctgatc aaataataaa
     2641 atatttagaa aaaaggttag aaaaatatgc agaaacatta caatatgccc atttatatcc
     2701 tgacacagtt attttaccgt tacagcaatt agttattgaa tattctttag acgttgctag
     2761 aattcggaag tatatgaatt taaaaacgta aagtgaaatt tatagtttaa atgaaacaga
     2821 gtcgacttta ggaaatgaaa ttctaatgtc gactctgttt cattgtttaa tatcgttgat
     2881 tgaacataca tactaatcaa tgaagtttga catataatta agcaagggta aaataaaagt
     2941 gagtactcac tcattttatt ggaaaaggag gatgaaacgt gcaacaacct tcaattattt
     3001 tacggactgt atcaaaaagt tttgggaaaa aagaagtgtt acacaatctt tcattacaag
     3061 ttgaaaaagc agagattttt ggttttgttg gaccttctgg atcggggaaa acaacgctca
     3121 ttaaaatgat tgcaggtatt aatgaggcaa cgaaaggtga agtgcttgtt aataatacta
     3181 atatgcctaa tttaaatgaa atgaaacgaa ttggttatat ggcccaggcg gatgcattat
     3241 atgaagaatt gtcagcatat gaaaatgcag attttatagc aacgatgtat ggattaaagg
     3301 gaaaaagtaa aaagacaaga attgcagagg tttttgaact tgtacaattg tcacagtata
     3361 tgaaaaagca agtacaacaa ttttcaggtg gaatgaaaaa acgcttatca ttagcaatag
     3421 cactcctcca tgaaccagaa atattaattt tagatgagcc tacagtgggg atagatccgc
     3481 ttcttaggaa aacgatttgg gaaaaatttt atgatcttaa aaagaaaggc acaacgatta
     3541 ttgtaacgac gcacattatg gatgaagctg aattttgtga gcgtctagga ttaattagag
     3601 aagggaaact agttgcggtt ggaacaactg aagaattgaa aaaacgcgtg tcatctggac
     3661 ggattgaaga tgtctttttg ctggaagagg tggtgccatc atgagagtta ctggtgtaat
     3721 tatacgtatt attcgtcaat tttttcgaga taagcgttcg ttagcaatga tgtttggagc
     3781 accgatgtta ttactttggc ttttgtcact agtgtttaca cagaaagact atataccgca
     3841 aattgctgtt gttgatatgc ctgctcaaat agtaaaaatg atgaaaaatc aagaagcgtc
     3901 aatttatgaa tacagtaagg aaaaggcgat ttctgagttg gaaaaacaaa aggtagatgc
     3961 agtatttcgt atagagaatg gaaaaatgaa acttctgttg gaaggtagtg attcgtcaaa
     4021 aaatcgtgct gtacttcaag tattgcaaaa aagcacagag aagaatgatg tatcgattat
     4081 gaaacctgaa gtaaattatt tacatggctc taaagacttt acgatgtttg atgggcttgg
     4141 tcctgtatta attggtttct ttacattttt ctttgtattt atattatcag gtgtatcttt
     4201 cgtaagagaa cgtttaagtg gtacgctaga aaggttatta tccaccccag taagaagatg
     4261 ggaaatagtc gcaggttata ttattggttt tggaatcttt gcctttatac aatccattat
     4321 tatcgtaagc ttttccgttt atattttaga tttatacgta gctggctcca tatggctaac
     4381 gctacttatt acatgtatgc tctctttaac tgcactaaca ttaggtacgt ttttatcggc
     4441 atacgcaaat aatgaatttc aaatgattca atttataccg cttgttattg tgccacaaat
     4501 cttcttttct ggattgtttc cattggaatc tatgaacaag tggctacaaa tgttagggaa
     4561 agtatttcca ctcacatacg gcgctgacgc aatgagacaa gtgatgattc ggaatcaagg
     4621 gtttacagag attgcattag atcttactgt attattactt ttttcaatat tatttgcagt
     4681 aggaaatgta tttgctttaa agaaacatcg caaaatataa taatgacaaa aaggagcttt
     4741 ataaatgcag aaggattggc tggaggaatt aatagctgca actaatacgg ataaacgaaa
     4801 tgaacgtcaa atgcgaatat tagaggcggc tgttgatatg tttggagaaa aaggatacgc
     4861 ttcaacttca acaagtgaaa ttgcaaaacg ggctggtgta gcggaaggaa caatcttccg
     4921 ctactataag acgaaaaaag atttattact agcggtcgta atgccaactt taactaagtt
     4981 cgctgcacca tttttcgtac aaacctttgc aaaagaaata tttaaatcgg agtatgaatc
     5041 atacgaagga cttttaaggg ttgtaattca taataggttt aaatttgctc aaaaacactt
     5101 tcctatgata aaaatattaa ttcaagaggt gccattccaa ccagaactga aaaatgaaat
     5161 acagcaatta gtagaaacag aactgttttc acatttcaaa aagttgattg tgaaatttca
     5221 agaagaaggg gaaattattg agataccacc atcttccgta ctacgtctta ctttatcagc
     5281 tgtattaggg ttattattaa cacgattttt attattgcct gaagaaaaat ggaatgatga
     5341 agcggaaatt gaaaatacga ttcaatttat attgtatgga ttaactccac gaatttaatc
     5401 gttgaagtgt gaattacata cattactttt aagtaaaaat aaatcgcctt taaaaaggcg
     5461 atttattttc attatatatt tttgataaat aagtgcttgt ttactaaaaa cattctaaat
     5521 cagcgtgttt ctttgtctct tcttctaaga cctaataatc ctgctagtcc taataaacca
     5581 agccaagccc aattattatt tttatcacga ttatcattta aatcatttgt tgtatttaca
     5641 tttcgagttc ttacatcatt attaactctg tctaagttat tgtcatttac tcgagttgaa
     5701 atatcagtgt tattaactct attcatatta tttccatcgt attcagcttg cgcagatgta
     5761 cctaaaaaca taatagagag tgctaaaaca cttaaaatag atgataattt ctttttcata
     5821 acaattccct cctttcttaa tcattaattt ctccgaagca tgtgtgtatt attcatttca
     5881 caatatctaa accctcatta atagggcgca catttataga aaatagagtt gaatgattgt
     5941 taatgtatca ttggatttat atttctcata aaaataactg aatcaaactt tgcttaaaat
     6001 gttaatctta gtacaattta tattatacgg actagtaata aggaggtaat aagatgcgac
     6061 aatttgcaaa acctacaatc gtcgtaagta aatgtttaga atttgatgct tgtcgttata
     6121 atggagagat gattccagat gtaacaatac gaaatttgca gccatttgtt acatttatac
     6181 ctgtttgtcc agaagtcgag attggattgg ggactcctcg tgaaacgata cgaattgtag
     6241 aagaaaatgg tgagaataga cttgtgcaac cgtcgacacg agaagatgta actgaaaaaa
     6301 tggagcagtt ttcaaatgac tttttacaaa tgataccgga tgtggatggt tttattttaa
     6361 agaatcgttc accaagttgt ggtacgcgtg atgtgaaaat ttattctggt tttgaaaaag
     6421 cgccagcaaa gggaaaagga gctggcttat ttggcggagc agtagtaaaa aaattttcgc
     6481 atcttcctat tgaagaggaa ggtagattgt cgaattttat tattagagag cattttttta
     6541 caaggctatt tacaatcgca tattacaaaa tgattaaaca caataaaaat atgaaagaac
     6601 ttgtatcgtt tcagtcggat aataaatatt tatttatggc atataatcag gtgaaacaaa
     6661 aggaattagg tcgtataatt gcaaatcaca aaaatgaaaa gattgaagtg gtatttgaaa
     6721 actatgagaa gactttatat gaattattta tgcgtgcgcc ccgttataca tcgaatgtaa
     6781 atgtatgcga gcacattttt ggatatttta aaacaaagtt aaaaaaacaa gaaaaagatc
     6841 attttataga actgttacaa aagtatgcag aaaagaaaat accacttagt agtttactta
     6901 caattttaaa atcatgggct attcgatttg atgaaaagta tttattaaga caaacatatt
     6961 tcgaaccata tcctgaagca ttagtagaaa tttctgattc cggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacacaaaa cctcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattagtac agaatctgtt ttaaaattaa gttatgacag aattatagca
     7141 attatctaac taatgttctt gtcttttaag ttgttatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg actttgctga aaaggaaatc gcaccgaaag
     7321 ctgtatatta tgacaaaact gcagagtttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattact aggcatccca ttcccagaag agtatggagg ttcaggtggc gatacggtat
     7441 cgtatgcgtt agcagttgaa gaaattggtc gcgcttgtgg tggcactggt ttaagctatg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 aaaagtattt agttccaatg gcgtcaggta aaacattagg tgccttcgga ttaacggagc
     7621 cgaatgctgg atctgatgca ggtggtactc aaacgaaagc ggtattagat ggcgatgagt
     7681 atgtaatcag tggtgagaag tgttggatta caaacgcaga gtatgcaaat acaattattg
     7741 taaccgctgt caatggcgtt gaagagaatg gtagaaaacg tatttctgca tttatcgtgc
     7801 ctactactag tgaaggatta acgatttcaa gtccatacga taagatgggt gttcgtgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg tgcgtgtacc gaaagaaaat attcttggtg
     7921 atgtaaataa aggttttaaa caatttttat atacacttga tggagggcgt atttcaatcg
     7981 cagcattggc agttggtatt gcgcaatcag cctttgaacg tgcattgcaa tatgcgaaag
     8041 aacgtcaaca atttggaaag tcaatctcta atttccaagc gattcaattt aaattagctg
     8101 atatggcgac tgaagtagag ctagcacgca atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa acctttcggc aaagaagcgg caatggcaaa actatttgca tcggaagcag
     8221 caagccgtat tgcgaatcaa gcagtacaga ttcatggtgg atatggttat atgcgtgaat
     8281 atgaagttga acgacatatt cgtgatgcga agctattaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gctagacatt taggatgtag ataaaaggga ggaatcacta
     8401 tgtttcaaaa aatattaatt gcgaatcgcg gggaaattgc tgttcgtatt atgaaaactt
     8461 gtcaaaaaat tggcatacgc actgttgcta tttattctga agcagatgaa aatgcccttc
     8521 atgtgaagat ggcaaatgaa gcttacttag taggtggacc gcgtgttcaa gaaagttatt
     8581 taaaccttga aaaaattatt gaaatagcta agaagacaaa tgcagaagcg attcatccag
     8641 gttatggttt attatcagag aatccgtctt ttccggttcg ttgcaaagaa gaaggaatcg
     8701 tatttatcgg tccttcagaa gaaatcatta cgaagatggg aagtaaaatc gaatcacgta
     8761 tcgcaatgca agcagcagat gtcccagtag tcccaggtat tactacaaat attgaaactg
     8821 ctgaagaagc aattgaaatt gcaaaacaaa ttggttatcc attaatgctt aaggcatccg
     8881 caggcggcgg aggcattggt atgcagttga tggaaactga gcaaacgctc accaaagcgt
     8941 ttgaaagtaa taaaacaaga gcgcaaaact tttttggtaa cggagaaatg tatttagagc
     9001 gatatatagc agacgcgcat catattgaaa ttcagctttt agcagataca catggtaaca
     9061 cagtgtattt atgggagcgt gaatgttcgg tgcagcgccg aaatcaaaaa gtaatcgaag
     9121 aagcaccttc accattttta gatgaaggta cacgaaaggc aatgggagaa gttgctgtac
     9181 aagctgccaa agcacttggc tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 agaagaactt ctatttctta gagatgaata cgagattaca agtagagcat ccagtgacag
     9301 aagaaattac gggattagac cttgtagaac agcaacttct tatcgcaagt ggagagaaac
     9361 tatcatttac tcaggatgat gtaaaacgta gtggtcatgc cattgaagct cgtatttatg
     9421 cagaagatcc gaaaacattc ttcccatcac ctgggaaaat tacaaattta acattaccgt
     9481 caaatgtacg gatcgatcac ttcttagaaa atcatgtaac gattacacct ttctatgatc
     9541 caatgattgc gaaagtcatt gcacatggcg agactcgtga agaagcaatt tcgaaattac
     9601 atgatgctct agaagaatta aaagtagaag gtattaaaac gaacacgcca atgctactgc
     9661 aagttttgga agacgaagtg ttcaaagagg gtatttatac aacgggtttt gtaacgaaac
     9721 aactcgttaa aaaataagat ttaacaatat taagggggaa aaaatgatga cgaaagtata
     9781 cgcatcgatg gcaggaaacg tttggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatca tttcagaaga
     9901 agtcggcaca gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attattagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtcgggc cacgtgatgg cttacaaaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagca ggattgtcgt atgttgaagt
    10141 ttcctcattc gttcacccca aatgggtccc tgcattagca gatgcaaatg atgtattttc
    10201 tgagctgaaa agggatccaa atgttacata tgctgcgctt gttccgaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcataataaa agtaatatta ataaatcgat taaagaagca ttagttgtaa ttgaagatat
    10381 aacaaaacag gcattattcg aagggaaaaa ggtaagaggc tatgtttcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgctac agcagttgac gaattatgta atcaactgtt
    10501 ttcatacggc atttatgaag tttctcttgg ggatacaatc ggtgtagcga atccattaca
    10561 agtagaacaa gtattagaac acctattaaa gaagtatgat gcttcgcagt ttgcaatgca
    10621 ttttcataat acgtatggaa tggctctagc gaatgtagtt aaatcattag aatacggtat
    10681 tacaacgttt gatagttctt gtggtggact cgggggctgc ccttatgcac caggagcatc
    10741 aggtaatgtt gctactgatg acctagtaca tatgctccat aaattaggag tccaaacgaa
    10801 tatagacgaa gaaaagttat tgagagctag tcaatttatt caaagtaagt taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagtagatgc
    10921 tacaattaca aaacatttcc gttgattacg taacacctca cgtagtaaag atttcgttaa
    10981 atcgtgcgag acaagcaaac tcattatctt tggcattatt agatgaatta caaactatat
    11041 taactcaaat aagtgaagat tcaagcgcac gtgtagttat tttgactggt gctggtgaaa
    11101 aagcattttg tgctggtgca gatttaaaag agcgtgccga tatgaatgaa gaacaagttc
    11161 gtcatgctgt tagtatgatt cgcactacta tggagatggt tgaacaatta ccacagccag
    11221 ttattgctgc tataaatgga atcgcacttg gtggtggtac ggaattaagt ttagcttgtg
    11281 attttagaat tgctgctgaa tctgcaagtc ttggtcttac tgaaacgaca cttgcaatta
    11341 taccaggagc aggtggtaca cagcgcttac caagattaat tggagttggt agagcgaaag
    11401 aattaattta tacaggtaga cgtatttcag cgcaagaagc aaaagaatat ggtttagtag
    11461 aatttgttgt accagctaat ttacttgaag agaaagcgat tgaaatagca gagaaaattg
    11521 ctagtaatgg acctattgct gttcgattag caaaagaggc aatttcaaat ggtattcaag
    11581 ttgatttaca taccggatta caaatggaaa aacaagcgta tgaaggtgta atccatacga
    11641 aagatcgaat agaaggatta caggcattca aagaaaaacg taaaccgatg tataaggggg
    11701 agtaaatatg ttagaccaaa aacaacaatc taattcattt gaagaacgtg ttgaaacgat
    11761 taaacaaggc ggggcaccga aatatcatga acaaaataaa gcaaaaggaa aattatttgt
    11821 tcgagatcgt ttagcgcttc tatttgataa tggcgaatat gtagaagatg cattatttgc
    11881 taattgtgaa caaacaggct tacctgcgga cggcgttgta actgcaacgg gtaaaataca
    11941 tggtcgtact gcgtgtgtaa tggctaatga ttctactgta aaagctggat catggggatc
    12001 acgcacagtt gaaaagattt tacgtattca agaaacagct gaaaaattac gtgttccgtt
    12061 attttattta gtcgactctg ctggagcgcg tattacagat caagtagaaa tgttcccagg
    12121 gcgccgcggt gcaggaagaa tcttctataa tcaagtgaaa ttatcaggta aagttcctca
    12181 agtatgttta ttatttggac cttctgctgc tggtggtgca tatattccag ccttttgtga
    12241 cgttgtaatg atggtagaag gaaatgcatc tatgtattta ggatctcctc gtatggctga
    12301 gatggttatc ggtgagaagg taactttaga agagatgggc ggagctcgta tgcattgctc
    12361 tgtatcagga tgcggagatg ttttatgtaa gacagaagaa gatgcgatta cacaagcaag
    12421 acaatacatt tcatattttc caaacaacta cttagaaaag actccattgg ttacacctca
    12481 agaaccgaaa caattcgata aaacattaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaatagagt tattgatgaa ggttcattct atgaagtaaa
    12601 aaaattattt gctcaagagc taattacagg cttagcacgt attgatggta agccagttgg
    12661 tattattgca aatcagccgc gtatgaaggg cggtgtatta tttcacgatt cagctgataa
    12721 agctgctaag tttattaatt tatgcgatgc atatcatatt ccattattat tccttgcgga
    12781 tgtaccagga tttatgattg gtacaaaagt agagcgtgct ggtattattc gccacggtgc
    12841 aaaaatgatt tctgcaatga gtgaagcaac tgtaccgaag atttctatcg ttgttcgtaa
    12901 agcatatggc gctggtttat atgcgatggc aggtccagca tttgaaccag attgctgcct
    12961 ggcattaccg acagcctcta ttgcggtaat gggtccagaa gctgcggtta atgctgtata
    13021 tgcaaataaa attgcagctt taccagaaga agagcgcgct agcttcattg ctgaaaaacg
    13081 tgaagagtat aagaaagata ttgatatata ccacttagca tcagagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gttaaaagga cgtttcgaaa tgtatatgag
    13201 taaatatcaa ttattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gttaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga gtataaggaa aaaacacgtt tatatggttg gatgaaatca ttgggatatg
    13381 aagactatga aactttttat aataaatcta ttgaggaaac agcttggttt tggggagagg
    13441 cagaaaaagc agtaggctat caatggatga aaccttatac agaagtgtta gatttagaaa
    13501 atggtacacc gtttgcacag tggtataatg gcggaacatg taacgttgta gaatcagctt
    13561 tatcccgctg gcttgcggat gaagaaacga gaatacagcc agcgcttcag tacgaagggg
    13621 aaaatggaac ttcaaaatca tttacatatg aagagcttga taactgggta agccgtgttg
    13681 caaatggttt gaaacacgcg ggtattgaga aaggtgaccg tgtaacaatt tatatgccga
    13741 tgattccaga aacagttgtt gcgatgctag ctgtaatgaa aatcggtgca attatttcac
    13801 caatattctc aggctttgcg tctgatgcag tcatgacacg tgtgcaagcg gcaggttcaa
    13861 aaatgattat taccgcagat ggattttcac gccgaggaaa aattgtttct ttaaaagatg
    13921 aagtagataa agcttgtgaa cattgcccaa ctgttgaaaa agtggtaatc gttcgtcatg
    13981 caggaaatga ttttacacca cataactatg acttttcgtg gagtacgcta gaaaaagaaa
    14041 aaccattcat acatgccgaa gaaatgcaaa gtgatgatcc attaatgctc atttatacat
    14101 caggaacgac tggtaagccg aaaggaacag tacacacgca tgcaggattt cctttgaaag
    14161 cagcttttga tgcaggattt ggaatgaata ttaaacaagg tgatcgtgta ttatgggtaa
    14221 ctgatatggg ctggatgatg gggccatttc tattattcgg ttcactcatt aatggagcaa
    14281 cgatggttat gtacgaaggt gttccagact tcccagaagc agaccggtta tgggagacag
    14341 ttgataaata tgaaattact catctaggta tttcaccaac gttaatacga gcattaatgg
    14401 caaaaggtga taagtatgtc aataaacatt ctttaaagag tttggaagta tttgcatcaa
    14461 caggagaacc ttggaatcct gatccatgga tgtggctgtt tgaaacagtt ggaaaaggaa
    14521 atgtaccaat ctgtaactac tcaggtggaa ctgaaatctc tggtgggatt ttcggtaatg
    14581 ttcttattaa gccaatagca ccgattagtt ttaatgcatc tttaccagga atggcagctg
    14641 tcgtactgga tgatcaaggt aaaccaattc gagatgaagt cggagaatta tgcttagaga
    14701 aaccttgggt aggtatgacg aaaagcttct gggaagatga tgaacgttac gtaaacacat
    14761 attggtcgcg ttttgaaaat aaatgggtcc acggtgactg ggtcatttac gatggtgaac
    14821 aatatatcat cacagggcgt tcagacgata cgttaaatat tgcaggtaaa cgtattggac
    14881 ctgctgaata tgaatctatt cttgtgaaac ataacgatgt aatcgaagct gctgcaattg
    14941 gtgtacctga tgaagtaaaa ggtgaagttt gtcattgttt cgtagtatta agagaccatg
    15001 taacattcac aggagaatta aagaaagaat taatgagttt agtaaactct catattggaa
    15061 aagcgttgtg tcctaaagac atccacgttg tagaagattt gccgaaaaca cgtaattcta
    15121 aagtgatgcg ccgtgttatt aaagcagctt atttaggaaa agaattaggt gatttgtctt
    15181 cacttgtaaa tcctgaagta gttccgttta ttcaggggtt acagtctagt aaattataaa
    15241 cataagaaag gatctctata taaatagaga tcctttctta tgtttataaa aagagaaaaa
    15301 gtgaagttga tgaagaaaaa ttctactatt agtgttaagt atgttttata gttttaatca
    15361 aaatacgata ttatggaatg tctactcaat ggagaaatac taatttacaa caaggtgata
    15421 acaaagcgtg cctgctttat atgtctgtta aaacttttac gtgttaatat ataaaaagct
    15481 gactatactc agtcagcttt ttatatatta cattctagta tttatttcac tatttgccgg
    15541 gcagtaatgc ccccacctaa aaattcagcg aaagtaagga agtaggtgtg ggattaactt
    15601 tccggaaaag cccgattggt tccaaaagcc atattctttc ctttacgttg acattaaaaa
    15661 aattaccaat tttttctttt acaatggcaa caaataaaga aacatttaca acgacactta
    15721 tttcgtttag aaccccaatc atcatcacga tgacactttt ctttagattt ccaccaatca
    15781 tcgtcacgat gacacttttc tttagatttc caccaatcat cattacaatg ctttttctga
    15841 gaactccaat catcatcaca atgatgcttt tctttagatt tccaccaatc atcacaacaa
    15901 tgctttttct gagaactcca gcaatcattt ttccaagaca ttcatttcta cctcctttca
    15961 atagtgttca tattattcta tgttttaata aaaaaatggc ttgtttatta acctactatt
    16021 ttatctttat atgatagagt gttttctact cgatatagag ttcatacaaa ccatgctaat
    16081 ttttaagaga tagtggagag aactactact agttatggtg ttttccaata aacatttgtt
    16141 gaagaaagcg ttctgattag aaataatatc ttattttcga gtacgctttt ttaaatgtat
    16201 atttcacaat gaaaaatggg aaatccacaa ataaagtcta tgtatatgtg agttaatgga
    16261 aaaatctagt gtgtttttaa ggagcgtctt atttaaaaga aaaaagattt gttttagaaa
    16321 gtggtgtcta aacattaaat ggagtaggac taaattcacg gccgctcatt aaacaagctt
    16381 ttaattagga gaagtctgtt tttataatga ataatgaaaa gaaagtatag tacaattgtt
    16441 tgtttttttc tttttatgtg tttgcctcgt acccttttaa gctagtggac atactttact
    16501 aatagaaagg attagggggt gaggtattgg gttctcgatt taataattgt aaaaagaagt
    16561 gtacatgtaa acaagatgat tgttgggaag tattcgaaga gtgtaaaaaa gaacagcatg
    16621 agaaatgtga taattcttgt gtacaaggaa ttagagatga acttaagaaa ttaattaatc
    16681 gaacagttca aattaataca gagggacgta cttatgtagg tactgtttcg tctgtaagtt
    16741 gtgatctagt taggcttgcg gctattcctg gatcggttgg agtaattatt tccatttgta
    16801 aaattgaagc aattttccca cctgttacaa cggttactgc tgactttgat tttaatggta
    16861 ttgatgtagc aaacaaagca taattatgct gcttttttgt aaagccattc acatgaatgg
    16921 ctttatttta atttcatata aaaggagaat atattcttta tatagaaata agtttcaggt
    16981 tataaagcat gatgtatgaa aggagcaagg aagtgattaa actagaaagc tttaagaaat
    17041 ctgattttaa acaattaata aattggatta actccgaaga atttctaata caatggtcag
    17101 gaaatgcatt cacattccct ttagacgaac agcaattaga gaagtatata gaaagtgcaa
    17161 atacactcgc tttcaaagtg gtagatgaag tgacctcaga cgttattggt catatttcgc
    17221 ttgggcaaat agataatatt aataagtccg ctagaattgg aaaagtatta gttggtaata
    17281 cgaagatgag aggacgttct ataggaaaac atatgatgaa agcagtactt catattgctt
    17341 ttgacgaatt aaaactacat agggtaactc ttggtgtgta cgattttaat acatcggcca
    17401 ttttctgtta cgaaaaaata gggtttgtaa aagaaggctt attaagagag tcaaaaagag
    17461 taggagaaac gtattggaat ttatgggaaa tgagtatgtt agaatatgaa tggaagaagt
    17521 agcaacaata gttatttata attatattat gttaacaaaa ggggcttggt gggtatagtg
    17581 gataataaaa caaaaataat ttcaattgca gctgtttcag ggggagagct agtatattaa
    17641 aactgacaaa gaaaccattt ttgaaaaagg cccacctgca ttgtttctga ggaataagag
    17701 ggtgagccct aattaaacga aactgaatga atctgtaaaa attgtaacta aagtatgcat
    17761 caacaaggta ttgaaaggga tgaatagtaa actttacaaa ttattccata tgtaacaaaa
    17821 ctggttagct tctgatttaa gcgctactaa atgattatta ttaatagagt tattcgtata
    17881 cattctgttc ttttggatgt taagtaccgt ataattcaca tcgtttcgtt catttgaaaa
    17941 tgttgattca tttaatagtg taagtgtcga gttaatgttg tatttatcaa ttcgctcttt
    18001 ttttcctttg aaaaacagtt tgataagatg tggctcatta ttaatgaata agccaagttc
    18061 aggtgatgaa cggacgatta aatcatctga tttccaatgt gatttacctg gatcaaacca
    18121 ggagatgtct ttatttttaa tgaatttttt gaattgcttt ataacatcaa tgtagttttg
    18181 tttttttttc tgatcaaccg tttgtactaa tgtttcgaaa cattcaaaag gtagtttgtt
    18241 ttgatgaaat ttaataacag tttctcgtaa ttgtttccag taatcaaaag ctggttgata
    18301 ttcaggttgg gattttagat tttttataaa gtttgtttta gctgtactac ctttcagtgt
    18361 gaagtctaaa aattgtgtaa gccctacttt aatttctgtc atattacatc acccttccaa
    18421 acattattca tttaataata gacgaaatac cctacatttt taaagaaatg agctagatgc
    18481 tagaaaacct aatgtccatg cacaatagat acgggaaagc caatccgtaa gtataaatga
    18541 tggaccatcc aattgaagat aaattagata atggttacca ggtgataggt tattaatata
    18601 atcggatagt gaggcgagtt taaaagataa caatatagat tatttagctt ggatttgaga
    18661 aaaaagtgca tgggaataaa gagggatata gggaaatggg ctctcatcaa aaaatataag
    18721 ttggtatcag tataccgtag agaatgagtg tatagaacat acaagtaaaa gtattggcta
    18781 gcacacttaa aataagccgt ataaaaagtt aatcatcgtg tgctttgatt atataatgtc
    18841 ggcgaaataa atagtgtgaa ggacagcgat cttaacaagt gtttcatgta acgttcatgt
    18901 actttaattt tttataatta atcaaatttg aattttgttt gttgttaaga aaaggtgaga
    18961 agaaaataaa aaaagagggc taatgccctc tttttttatt aatttggtaa ttaatcacag
    19021 attggtatcc caagcactct tagagctaat gctacttgaa gggaaatctc taatctagca
    19081 atttcaatac cagctactga aagaactaaa aaaggttgtc cgtttacaaa tacaacgcaa
    19141 ctatccatag ttaagcctcc tttctagtaa tctactatag tatatgaata gaactttaat
    19201 atgtaatagt taaattgttg gatttaatag aattaataga ttaacccatt taaactaaac
    19261 aaacgaacac aacgaacgga aacagagatg gatgtatgcc tcgaaaaaca taggttttaa
    19321 gacatgggat atgaaattca tcatattggt cagctgtcta tatgggcgag gcagttaaac
    19381 ttgcaaccag tttcagcaaa tttaattgga agaggatgat agaattaaaa accgacttgc
    19441 atctcaaacg caagtcggtt tttatatata agaagatttc ttaattgaaa tcctcggatt
    19501 ttttctgacg tatatgtaaa aacattaagg tggtaatgat taaaaaaatc attatagttt
    19561 gtataattaa atttttaaac tgaagcaata ttgtccacga tgtaagggtg tctttaaaag
    19621 cttggagtgc agagtacgag gaaggatcaa aaccatactg tagcaacttt tttgtttcaa
    19681 taaatgaaat gttttcttca tctgcatcta atattactga aattagtcta gtatcttcaa
    19741 gttttgctgt actgacaaaa ctataattac cattagttga aaaactagtt tgtaagccat
    19801 caacaccttg aagtttaatg ttttcattaa gggaatatat cattttattc gtattgaaaa
    19861 cctgggaatc tttgaaggaa aattggtaag aggttagttt cgtaatattc aatacatctg
    19921 gaaaatcttt tattaatcgt gctgctaatt tagctgcgtc tattgctgtt gtagttgatt
    19981 gtttatttgt atcattatta tttccagtag agtttagaaa tggagatggt tgtaataact
    20041 ttagttcttt tgctttttta ttcattaata ctgtaaagtt atcttcattt ccagcaatgt
    20101 gttctgcaag agcgagtgca gaacgattat tccctgccag tagcaatgca tgaagtaaat
    20161 cacgaaccgt tgttttatca ttcgatgtta cttgtatagg gcttgtttct actcggaaaa
    20221 cttcgttact tatttgtacg aagtcatcta actgtatttt tctatcattt agttgctcca
    20281 atacgatata ttctgtcatt aatttagata aagcagctga ttgtactgga gtttcttcat
    20341 tttttttata aacaatttca cctgaattag catttattaa gatagctgat ttagcttgaa
    20401 taatcggacc atttacataa aggtaaaaat ataaaacgat aagtgcagta atgaaaaaag
    20461 ataataataa aatagcgaat ttttttaaga attgcataag cgatcctcct attatgacat
    20521 caataatagt attgtaaaaa agaatgctta attaggaaga aagaaaaggt aaagaatttc
    20581 taaagaatta taaaggatta ttattttttg taattaatgg aaaaagttca atttcttata
    20641 tgataagaaa ttgaactttt tatttgtgat attaaccttt gtaggggagt agttttacag
    20701 tgaaagtagt tttttcgtca tcactatata cttcaattgt tcctttatgc aattcgacta
    20761 tactttttgc aattgctaat ccaagtccag atccaccagt gtttgtagag cgcgattttt
    20821 caacgcgata aaaacgttca aaaatatgag gtaaatccgt actaggaata ggttgtccgt
    20881 aatttgttat atcaattgta atcatattat tgctttcata agcagtaagg tcaatatagc
    20941 gaccttcgct tccataagcg atagcgttta taataagatt ttcaaacaca cgcactaatt
    21001 tgtcaccatc agctaatacc atgagctttt gagatgggaa agaaggtcta cattctatat
    21061 tagcttcttg aacctgtatt cggaattgaa cagttaattg tccaagtaac tctacaatat
    21121 caatggggac agaatacaag cttaactctt tattttgaac acgtgtatat tcgaacaagt
    21181 cattcattaa tgcattaaga cgagttactt tatcataaat gacttgaata tagtatcgca
    21241 attccacttc atctctataa ttatcatgat gaattaaatt tacgtatcca actatagaag
    21301 taaggggagt acgtaaatca tgtgatacat ttgtaataag ttcactcttt gcttgttccg
    21361 cttgtctttc ttcatcaatt gagactttta attgttcaac aatttcattg accccgattg
    21421 ctaactcttc caaataatta tgatttacaa cagaaacttt atgattgaag tttccatttg
    21481 caatgtaacg aatttcttct atcatttttt ttatacaagt ttcatagtaa agttttctct
    21541 cgtgacgata aaaaatgtaa agataggatg aaaaaataga aaataaaaac aaataagaaa
    21601 caatcatcat ccataaagat tctttaaccc ctttatactt ttcataacca aaaattcgaa
    21661 tgaattcttt accgagttcg gttagagtaa gtgaactttc aattacactc gtaacgaggc
    21721 gataaataat taattcagta ataggagtga gtgtgatagc tagtaagagc caaaaaataa
    21781 gtttccattt agggatatct tttaatatat caaatgcttc atttctcaat tttatagcca
    21841 actccccaaa cagtgtgaat aaatttttct ccattcatta ccgtttcaag tttatcccgt
    21901 aagttgctaa tatggaccat taccgtctta tttgaaccat aaccatcttc attccaaacg
    21961 cgttcgaaaa tttcttctga actaaatact cttcctgtat tactcgcaag taaatataaa
    22021 atatcgaatt caatagaggt tagtttaata tactctccat ttactttaac agtatgatta
    22081 tgtttgtgta tttcaacaga gcgaatacga ataataccat cttcattctt ttgcgaagta
    22141 gcattttgga aagatgatct tcgtaataaa gctttcactc tagctactaa ttctaatgga
    22201 ttgaatggtt tgatcatata atcatcggca cctgtcataa gacctaatat tttatccata
    22261 tcttctgctt ttgcactaag cattagaatt ggtacagtat tattttcacg tacttcctga
    22321 caaacttcta atccgtttcg ttttggcatc ataatatcca aaatcataag gtcaacttca
    22381 tatgtagaaa ccttctgcaa tgcttcatcg ccatcataag ctttataaat gttatagcct
    22441 tcatttcgca aataaacagc aagtaattca acaatttctt tatcatcatc aataattaat
    22501 atgtttttat tcattttgta gttcctttcc ttacaaatca tcaacattac tataatatca
    22561 aacatttatg tacttgtagc aatgattctg tataaaattt catgtaacgt attaaaaagg
    22621 agtaaaaaga ttaataacga atataaaata acaaagatat ttaaattctg cattatactg
    22681 aaagttagtt ataaggggga ttttctatgt tatataatga tatatattca tttgctccaa
    22741 ctggaaaaat agacaatgat attaaagatt ttctactaaa atataataaa gagtttacat
    22801 ataaacattc aattcgtgtg gcaaatgagg caaaaaagat tgcagaaaag tttcacgtag
    22861 ataaagaaaa agcagcaatt gcaggatatt tacatgatat tagtggcatt tttccgaacg
    22921 aggagcggat tgcagttgct gaagaatttg gggtagaaat agaggaagca gaaagaaagt
    22981 ttcctatgat tattcatcaa aaactatcga gagtaatcgc aaaagaaata tttaaagtag
    23041 aagatgaaga cgtattagat gcaatttgtt gtcatactac actgcgtaaa cacccaacaa
    23101 agatggattt agttttattt gttgcagata aaatagaatg ggatcaaaag gggacaccac
    23161 catatttaat agaaataaaa aaaggattgg aaaaatcttt ggaaaaagct gcttttgtat
    23221 atatttcata tttgtgggaa aggaaagata cattgaaagt tatacatccg tggctagaag
    23281 aagcatattg gtatttaaaa agaattgtac agtagaaggg acaaggaaat gcaattaaaa
    23341 gaatatatga atcaaacatt tccaggagtt acattagtac cgtacttata ttctcagtgg
    23401 ggaaatcatt tgtattttga ttttggaaaa gataaatatc aaattgtaga aggaaccgac
    23461 gatttaaata tggaatactt ttctcagcta tatacatata ataacttctt atttgaagac
    23521 atattttcaa aagaagatgt agtgtttgta gtgacaaatg tttatagatt taaaaaggaa
    23581 aacacaaaaa ctccacagaa aataaatgta tacaataaat atattaagaa aagagattta
    23641 agatttcata taagacaaga aacgttaccg tttctatttg aagatgaaga ggcagattta
    23701 tctcgctatt tgccgggcag taagaccccc acctcaaaat tcagcgaaag caaagaagat
    23761 aggtgggggg cgggctgccc ctaaaagccc gattggtgag ggctgataat cagtggggga
    23821 tgaactgatt aaagtttcac attatattgt acatatcaat tttctttaaa atgtcttgcg
    23881 gaagatatta aatatgaatc gcttatacaa gctgctaatc atgaggattt ctctattttg
    23941 tatcctcgat ttggacggaa aaaagaaatt tcttatccag atgtatttct cataaatgca
    24001 acgaaagata ttgtcatgtt tatgtatgat gatagaggat gtgaagtaat tgcgaagaat
    24061 aaagaaataa tacgagattt atataagaaa tataaagaat ggattccaga ttatgaacga
    24121 gaaagtatag ataacttatt taaatgacaa taggggaagt gaagcgtgta atgaaacgta
    24181 ttgcaattgt atctgcatgg gaaccagaac tgacgtattt gcatcaacat tatccgagtg
    24241 aacgtgttga aaaaagagca gcttgggaat ttcattttca tactatcaat gagctggaaa
    24301 ttatatcagt tgtaactggt gtcggtaaag taagctgcgc tagttgtgta caattgttaa
    24361 ttagtgagtt tcagccagat gagttgttta tgacaggaat atgcggaagt ttatcaaaca
    24421 aagtgaaaaa cggtcatatt gtagtagcac taaacgcaat acaacacgat gttactgctg
    24481 ctggctcagg agaagatgtt tttaatttat ataacggtag aacagcacct attgaaacaa
    24541 caaaatcact tgtaagaaga ataaaaaaaa tacgattgta tgatccgata catttcggta
    24601 catttttatc tggagatcaa cgtattcgta gttcagaaat gagatattta cttcatactg
    24661 tatacggagc attggcagtt gatcaagaag tagcagcttt cgcctatgtg tgtcaaataa
    24721 ataaaaaacc atttttatgt ttaaaagctg cttcagatca agcaaatgat aaaacgaaag
    24781 aagaacaaaa aatctttaaa atgctagcat gcgaaagagc atgtgagcat ttaattgctt
    24841 ttttacgtgt ttatgagatt aatgtagtaa ataatagata gtttgttata aaacaaatta
    24901 atagtaagtt atatgtaggg aaatgtccgt tcatttcaaa ttaagagctg aaatttataa
    24961 tagatggaat atattatatg ggtacatgtt gaggttaata caagcaattg gagggcaatt
    25021 ttatatgatt caatataaaa ggtgtagtga agtaaatatt gatttagtat atgaagcttt
    25081 taaagatgga ttttccgatt atattattaa gatggaagtt tcaaaagagg gttttataca
    25141 acgttttttt ggaccagaag gtaatttgct agaacattct tttcttgctt tagacggtga
    25201 caaatcagtt ggcgtaatat taggtggtat aaaggatta
//
