LOCUS       NZ_CP023477            42094 bp    DNA     circular CON 18-JUL-2024
DEFINITION  Streptococcus mutans strain LAR01 chromosome, complete genome.
ACCESSION   NZ_CP023477
VERSION     NZ_CP023477.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2088369)
  AUTHORS   Abranches,J., Lemos,J., Kajfasz,J. and Aviles-Reyes,A.
  TITLE     Whole genome sequence and phenotypic characterization of a Cbm+
            serotype e strain of Streptococcus mutans
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2088369)
  AUTHORS   Abranches,J., Lemos,J., Kajfasz,J. and Aviles-Reyes,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-SEP-2017) Oral Biology, University of Florida, 1395
            Center Drive POBOX 100424, Gainesville, FL 32610, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: celera v. 9/01/15
            Genome Coverage                   :: missing
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002995555.1-RS_2024_07_18
            Annotation Date                   :: 07/18/2024 01:10:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,086
            CDSs (total)                      :: 2,002
            Genes (coding)                    :: 1,930
            CDSs (with protein)               :: 1,930
            Genes (RNA)                       :: 84
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 41 of 72
            Pseudo Genes (incomplete)         :: 35 of 72
            Pseudo Genes (internal stop)      :: 29 of 72
            Pseudo Genes (multiple problems)  :: 25 of 72
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:47:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1900585
            Orig. end                         :: 1942679
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023477.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Jacqueline Abranches.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..42094
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="HR-T2PKS"
                     /product="butyrolactone"
                     /region_number="9"
                     /rules="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..42094
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="HR-T2PKS"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..42094
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="False"
                     /core_location="[20000:22094](-)"
                     /cutoff="5000"
                     /detection_rule="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /neighbourhood="20000"
                     /product="HR-T2PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..22094)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(hr-t2pks-ksa and (t2fas or APE_KS2 or
                     ketoacyl-synt))"
                     /neighbourhood="20000"
                     /product="HR-T2PKS"
                     /protocluster_number="1"
     misc_feature    64..78
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(753..2600)
                     /locus_tag="CO204_RS09705"
                     /old_locus_tag="CO204_09655"
     CDS             complement(753..2600)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019322716.1"
                     /locus_tag="CO204_RS09705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09655"
                     /product="hypothetical protein"
                     /protein_id="WP_019313446.1"
                     /transl_table=11
                     /translation="MIKDLRLRFLDNLKSNKEIKNSGNDSNDDSLMLSSYLSYSIVFLI
                     YAIIITYISYISINRGSWMYDYSFHMSRIVGLAQSLKNGDWLPNLNYVIANNSGYAVTM
                     FYGNWQLYIPALVFLATKTATFAYSVYAFLLIYSSSLTGFYSLYQMSKSRKRAFIFALI
                     LPITIPFFGYGMVAAIPLIPLLFYSLYKVIYSERYNPMLLAAVISLLIQTHVISTIVLG
                     IASAIFVLLNSNQLTRQKLFSFSLSLVIGLIMTSGYIFQYVEQTQSQTFFVSWIIRDFP
                     FPAKILMLPNSVGDAIINYQFPIAIVIIVIGLVSSFWIKSVSRKLILMSLLLLFSTTTL
                     IPWKILKYSFLGVFQYTNRLVYFLPIYVLMAACISFNKYLVISICIFQFGYYIVTQPYK
                     YSYEEYRESIEYLKNTNTFAVKAFKNPLQLSYDTSGDEYLNLSVNHDDMRNGLSLNQFL
                     YNQQEVAIENVRQKYNDLEFDVSLKSNQPQTIVVPRIWYKGYKAYYSDEAVGTQPKIIY
                     QKLSKEELAQYSKAKKPKVTEKALYNGFATISVSHSGHVQIAYKKTFVQCIGYTIEILA
                     WLPRKVRQQLWMVLSKIGETIILCSKKIRQYVDENLKQK"
     tRNA            2879..2949
                     /anticodon=(pos:1903496..1903498,aa:Cys,seq:gca)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CO204_RS09710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="CO204_09660"
                     /product="tRNA-Cys"
     gene            2879..2949
                     /locus_tag="CO204_RS09710"
                     /old_locus_tag="CO204_09660"
     gene            3395..4351
                     /locus_tag="CO204_RS09715"
                     /old_locus_tag="CO204_09665"
     CDS             3395..4351
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002266278.1"
                     /locus_tag="CO204_RS09715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09665"
                     /product="S66 peptidase family protein"
                     /protein_id="WP_002262349.1"
                     /transl_table=11
                     /translation="MKKLTYGDHIRVLSPSNSIESLGGFNANLSAKRRLEKLGFTVSFS
                     NNYMENDLLNSSSIASRVSDIHDAFREEHVNAILSTIGGFNANEILPYLDYKLIKSHPK
                     IICGYSDTTALLNAIYAKTGMETYMGPSYSSFKMEEGQDYQSRMWLNAVTRHVYNLVPS
                     DKWSSDPWYDPSQPRHFMPTEWKIYNNGKAEGIAIGGHLATFGLLRGTEFAPNPENYIL
                     FLEGSEEEKPTEISRHLAAVLQTYPNPQAVIFGRFPKECQMTEKIWHFILDKHPVLKQI
                     PVMYDLDFAHTQPLFTFTIGAKVTIDTISRAIQFKTT"
     gene            complement(4496..6391)
                     /locus_tag="CO204_RS09720"
                     /old_locus_tag="CO204_09670"
     CDS             complement(4496..6391)
                     /EC_number="3.4.24.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002262350.1"
                     /locus_tag="CO204_RS09720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09670"
                     /product="M13-type metalloendopeptidase"
                     /protein_id="WP_019313447.1"
                     /transl_table=11
                     /translation="MVRLQDDFYNAVNGQWEEAAVIPDDKPRTGGFSDLADDIEDLMLE
                     TTDKWLDGKDVPDDSILQNFVKFHRQVADYDAREETGVKPVLPLIEEYKSLTSFADFAS
                     NIATYEMAGKPNELPFGVAPDFMNAQMNVLWAEAPNLILPDTTYYVEGNDKGKELLAKW
                     RAMQEELLPKFGFEEAEIKDLLDKVLTLDAKLAQYVLSSEESSEYVKLYHPYDWADFTK
                     LTPELPLDAIFTQILGQKPDKVIVPEERFWTNFAVEFYSEKNWPFLKATLVLAAASSYN
                     SYLTDDIRILSGSYNRALSGTPQAMDKKKAAFYLAQGPYNQALGLWYAGEKFSLEAKKD
                     VEAKVATMIEVYKERLHKTDWLAQETRNKAITKLNVITPHIGYPEQLPKTYAQKIIDDN
                     LSLVENAQNLAKISIAYNWSKWNQPVDRSEWHMPAHMVNAYYDPQQNQIVFPAAILQAP
                     FYSLEQSSSANYGGIGAVIAHEISHAFDTNGASFDENGSLNNWWADEDYAAFKERTDQV
                     VEQFEGLDSYGAKVNGQLTVSENVADLGGLACALEAAKREADFSVRDFFINFATIWRMK
                     ARDEYMQMLASIDVHAPAKWRTNVTVTNFDEFHQEFAVKEGDGMWRDEDKRVIIW"
     cand_cluster    4515..15303
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    4515..15303
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[9514:10303](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(9515..10303)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     misc_feature    6845..6863
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 26.22"
                     /tool="antismash"
     gene            complement(<7028..7924)
                     /locus_tag="CO204_RS09725"
                     /old_locus_tag="CO204_09675"
                     /pseudo=""
     CDS             complement(<7028..7924)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002281774.1"
                     /locus_tag="CO204_RS09725"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09675"
                     /product="ATP-binding cassette domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKKKMMELNQVKKVFGEQTAVDLNNLKIEQGEIYGLIGPNGAGKS
                     TIMKMICGLLTPTAGQINVAGSAMKENNRIAILKQIGSLIEEPAYYDNLTGYENLQILK
                     ELKNLTDQDVAEVLTIVHLTENKDKQVKYYSLGMKQRLGIAMAIMGHPKLIILDEPTNG
                     LDPQAREEIRKLIRILPATFNTTVMISSHALDEIEKMVTLIGIIGKGKLLYQGTVEQFK
                     SQYSRSICLRTSDDMLAVSLLDLDPNDVKATDQGLLLSYLSDEQVALTVKRLLEADVAI
                     YRIYEVTKSLEELFIDFT"
     gene            complement(8200..9522)
                     /locus_tag="CO204_RS09730"
                     /old_locus_tag="CO204_09680"
     CDS             complement(8200..9522)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263962.1"
                     /locus_tag="CO204_RS09730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09680"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_002263962.1"
                     /transl_table=11
                     /translation="MNKLEKESIKNLLIQLMIPSLVTALVTGSYNLVDGIFIGQSLGIA
                     GTSANVYIFMIYTLIYSFSALASEGTASLLTIILGEAKYKKAEEVLSISVLLSLILSVI
                     QSILIWGGLDYLLRIFGTPSILYHFIWEFTSVFLIGSPVYFVSHTLLSCVRAQGAVKEV
                     LYINLISFVVNTGTGGIFILIFHMGFTGSALSTILANLTILVMTCYTYLKTSSNLKLKF
                     FFPDSKTLLKRAKRIINMGLPFFLTTIISVLLLILYNRVALAYASAYGVAALSIVSSIY
                     RYIISLMNAITNGIQPIISFNYGAQNSVRVQKSLRSSLTVGTLFSIFLFVIIQLYSKEI
                     VSLFNSDSKSFVAFTSSALRIVMLSLPLQGIINIGTNYFQYISQPRVSTILVILRQIIF
                     QIPLAVFLPLIFNISGLWDSYYISDLLIFLLIIWLIKKRNQ"
     gene            complement(9515..10303)
                     /locus_tag="CO204_RS09735"
                     /old_locus_tag="CO204_09685"
     CDS             complement(9515..10303)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263960.1"
                     /locus_tag="CO204_RS09735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09685"
                     /product="AfsA-related hotdog domain-containing protein"
                     /protein_id="WP_226711261.1"
                     /sec_met_domain="AfsA (E-value: 2.8e-08, bitscore: 30.6,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCIIMRSILQDNFDNDFTICKRKKEQVDALKSSIIISSDIEEIKQ
                     ILSILKQSVSIYLPDFNDNSDFFQWLKNKTYEDVKQNLKKATPKQIMALCDRIGIPLKY
                     SNILLSSSSKADQALVHKISNKNIMVSKSERIGGTNVFYLRGYFKTGEIILDHEAKDHV
                     ESILLAEICRQACLATSEVALKGEMHYMIPTEEYKVYKKFVSLEHPLLIQVISGKTRKY
                     SGYYVFALYQNNECCLKGYMLGRIFKNRIFFKEIRERLDE"
     gene            complement(10335..11003)
                     /locus_tag="CO204_RS09740"
                     /old_locus_tag="CO204_09690"
     CDS             complement(10335..11003)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263959.1"
                     /locus_tag="CO204_RS09740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09690"
                     /product="HAD family hydrolase"
                     /protein_id="WP_002263959.1"
                     /sec_met_domain="HAD_2 (E-value: 4e-06, bitscore: 24.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKLIACDIDGVLLKDTFSPILHRLAKKYGIPYTADLENNTFS
                     QNRSEAASYVKNNLCLPKNISVQELLKEYFEERTEFIKYDRSPILSGVPEFLQLLKSLN
                     VSLVCYGGLDEKMIDPIFKPYLKYFDCYICTNDFRPGLKEIVTKYHFDFSQVLFIDDVN
                     RVAEEAKKYGSPFIGVPAQHSWGFQEEEMKKTGVKYIVHSVKEITKNYLEKVDLDKSIW
                     "
     gene            complement(11093..12295)
                     /locus_tag="CO204_RS09745"
                     /old_locus_tag="CO204_09695"
     CDS             complement(11093..12295)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002285235.1"
                     /locus_tag="CO204_RS09745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09695"
                     /product="NADH:flavin oxidoreductase/NADH oxidase family
                     protein"
                     /protein_id="WP_002263957.1"
                     /transl_table=11
                     /translation="MLLLSEITLPNGRKIKNRMVKSAMGEGLADNHNQPTDELIQLYKR
                     WANGGVGLLISGNVKVDRKHLSSPGNLVIDDDTNLDKLRSLANAGTENNTCFVLQINHP
                     GKQTPKVMTKEPVAPSAIPIMKKLRGAFNTPRALLIEEIQDIIQKFINVGKIAQKAGFS
                     GVQIHAAHGYLINQFLSPVDNQRTDQYGGNLENRMRILIEIYQGLREVTSPDFIIGLKI
                     NSSDFTEKGFNREDSYQVILKMAELGIDFVEISGSNYEKSKIIESKNKELFFLEFAKKI
                     QKQVKFPVILTGGLTHTKVMEEVVSSEGIAMVGLGRALVMNPELPNQISTGSCNLVNLP
                     RLSTKIRRFDDKIGSIVGLSYYKQQMRRLAHGKDTKFTTNAWPVLFNAIMRQVQNSFKI
                     K"
     gene            complement(12568..14043)
                     /locus_tag="CO204_RS09750"
                     /old_locus_tag="CO204_09700"
     CDS             complement(12568..14043)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263956.1"
                     /locus_tag="CO204_RS09750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09700"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_002263956.1"
                     /transl_table=11
                     /translation="MYDVIIIGSGLGGLSSAAFLSKAGKKVLVLEKMRQIGGYAYSFSR
                     KKEEYEISLHSIGDLDNDGSLYKVLSEIELFEKVIFKKQVSNYSIVNENGIISSINGID
                     DFTKKLKLNYSENEREIHTIINLFKTIRKEMNYLNSFSEKEPLTNLKDNIPTILKYKDS
                     SLHHLLSTITDNQALIEEFSRYWVYFSLPPQELGGVIYAYVWTEYMIHGSYYPEGGSKA
                     ISEAFKTIIIDNNGEVITGSEVKKIMIKDSEVVGVECRKKQYFSDIVISNISPTATIRL
                     ANEENFPKRYLKKIDNIIPSCSSFVVYITLNRDFYELYSYAKGGHEFFLNNSKANSFWE
                     NLKSENISDLPINCSIYKDSKGKYTIVSLCTVSQFANWNRVDRKTYRTKKERWEKGLIQ
                     KMDTIFSGFSEYIVEKVSGSPLTNMRFTSNPRGAIYGSAQVVNQTLNRRLDNQTPVKGL
                     YFSGAWTKPSSGYSGVIWSGYNVHKLVLNQNKI"
     misc_feature    14098..14112
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.38"
                     /tool="antismash"
     gene            complement(14531..14773)
                     /locus_tag="CO204_RS09755"
                     /old_locus_tag="CO204_09705"
     CDS             complement(14531..14773)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002293216.1"
                     /locus_tag="CO204_RS09755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09705"
                     /product="hypothetical protein"
                     /protein_id="WP_002293216.1"
                     /transl_table=11
                     /translation="MLKASSVDIMTPYVPLEIIRNSQKVTNLIIRNVKSDNVIDFGLDV
                     LIISFVFSTFNKNLKDLGVDYRRSSIQILSSFETS"
     gene            complement(14963..15226)
                     /locus_tag="CO204_RS09760"
                     /old_locus_tag="CO204_09710"
     CDS             complement(14963..15226)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263954.1"
                     /locus_tag="CO204_RS09760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09710"
                     /product="NAD(P)-binding protein"
                     /protein_id="WP_002293215.1"
                     /transl_table=11
                     /translation="MINLRKEIYGLTIIGGGPVGLYTAFYAGLRGMKIKIIESLPELGG
                     YPAVLYPENNNTFIIITNKKHHMSRAIIIGNNSLLSRTLEVK"
     gene            complement(15281..15850)
                     /locus_tag="CO204_RS09765"
                     /old_locus_tag="CO204_09715"
     CDS             complement(15281..15850)
                     /NRPS_PKS="Domain: ACPS (85-145). E-value: 4.3e-10. Score:
                     31.5. Matches aSDomain:
                     nrpspksdomains_CO204_RS09765_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002297931.1"
                     /locus_tag="CO204_RS09765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09715"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_002263953.1"
                     /transl_table=11
                     /translation="MNLKLINGRDCVLLFDFRKFDIKYNSFFSSGKNKLWEKILKQIYK
                     NKTLDFSRGFYGKPFVIPDIFEFNVSNKDDILVIGLSASPIGVDIESLTLPVKYNSSVL
                     GHFFNLKEIAYLKETKDQSELFGRLWSLKEAMVKCKGIGLSFIPESDVLLTKQGLKLSD
                     GYRARSFIYENYIISVIIRSSINNEN"
     aSDomain        complement(15416..15595)
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CO204_RS09765_ACPS.1"
                     /evalue="4.30E-10"
                     /label="CO204_RS09765_ACPS.1"
                     /locus_tag="CO204_RS09765"
                     /protein_end="145"
                     /protein_start="85"
                     /score="31.5"
                     /tool="antismash"
                     /translation="IGVDIESLTLPVKYNSSVLGHFFNLKEIAYLKETKDQSELFGRLW
                     SLKEAMVKCKGIGLS"
     gene            complement(15831..16256)
                     /locus_tag="CO204_RS09770"
                     /old_locus_tag="CO204_09720"
     CDS             complement(15831..16256)
                     /EC_number="4.2.1.-"
                     /GO_function="GO:0016836 - hydro-lyase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263952.1"
                     /locus_tag="CO204_RS09770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09720"
                     /product="3-hydroxyacyl-ACP dehydratase FabZ family
                     protein"
                     /protein_id="WP_002263952.1"
                     /transl_table=11
                     /translation="MNDVRKKLKQRPPFLMVDRVIKADEDEVTCEKFVSENAAYLQGHF
                     PEDPVFPGVLIIEFAAQSSMFLDFEKLGLEANNGYLANVEKFTFSELVRPGTILISRVH
                     FKRVFGNFVITECEISDDQNNKVAKGILKFFIESKIN"
     misc_feature    16403..16417
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.38"
                     /tool="antismash"
     gene            complement(16452..17942)
                     /locus_tag="CO204_RS09775"
                     /old_locus_tag="CO204_09725"
     CDS             complement(16452..17942)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002297930.1"
                     /locus_tag="CO204_RS09775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09725"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_002263951.1"
                     /transl_table=11
                     /translation="MKSNIKTEYDYIIVGAGMSGLAAGIYLSGQGYQVLICEKHNKAGG
                     YVHSFSRKKIYTFDSAVRIVAGAKHGLLADLLDSLEIKNRDFFIELDDIYKTITPNFSF
                     NSGRDLEAFKANLKATFPKNKQDVDAIIDEMKSVYYDVLSVQKNERSILDAQYINKYRD
                     DSFSELLNQFTENNNLKLAISTLWGFFGTIPEDASAIYYSYAILSFFIEKAYYVKGSFD
                     TLTEALTKKFQENGGDLVYRAEVIAINIEEGSASGLVLKRKHMSVSARKGIIASGDILK
                     TVENLVGEIYFPKRYLSKLKKLTLPFSVFQTYLATDLKKEQLDLAHENFYFADRSNSDI
                     RSSFSNLEADISSFSISAPSLIDGSLTVDNSTLLVLSTFVPYSVDGGWKNRKKVFEDAL
                     IKEASHVIGDLKKHILFQESGTPETMERYTQNSGGSPFGWEQKKEQIFQRPNFATPLDK
                     LYFTGHWTNNGGGIVSAILSSFNLVEYLKKSEKYTSVM"
     misc_feature    18123..18136
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.39"
                     /tool="antismash"
     gene            complement(18249..18899)
                     /locus_tag="CO204_RS09780"
                     /old_locus_tag="CO204_09730"
     CDS             complement(18249..18899)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263950.1"
                     /locus_tag="CO204_RS09780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09730"
                     /product="hypothetical protein"
                     /protein_id="WP_002263950.1"
                     /transl_table=11
                     /translation="MNIIITQTKYEVNRKLASSLKKMGHQVICVADICCLTDGEKGEYN
                     RFFDDLRNRIDIFINGIIDEDESFLIEQNYKDYCLNKLQPFLDQLFSFNQTVSANMMRG
                     KNTNILFLLKYDVLRYHGVVSSPIYNNLVLSLVKSLSKELSSFSISVNALTLGAGFYFK
                     QLQKENMKIFNLKPSLRKIEEVAEVVELMGIYNGKSILSGQNVELSPGTDTTI"
     gene            complement(18902..19624)
                     /locus_tag="CO204_RS09785"
                     /old_locus_tag="CO204_09735"
     CDS             complement(18902..19624)
                     /NRPS_PKS="Domain: PKS_KR (3-159). E-value: 6.4e-10. Score:
                     31.2. Matches aSDomain:
                     nrpspksdomains_CO204_RS09785_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263949.1"
                     /locus_tag="CO204_RS09785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09735"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_002263949.1"
                     /transl_table=11
                     /translation="MNILLTGITGVIGKSIFKSLVTKKHNIFGFYKGNEAAALELKELS
                     RYAKGNLFLFKGDSSDIYFLESSVEEIISTNGDIDLVIHNAGKNKDNFFLNMTMEEWHS
                     VINTNLIANILLTQTILNYQSKQNFRILNVISVSAIYGREAQTNYSASKGGVVGYSKLL
                     STRKGSDIQIVNIAPGMIASSMVDGVPKKSLENFLDYTSKRCLGSADDIAEFVDYFAHM
                     TSRYMTNMTIKIDGGFMR"
     aSDomain        complement(19148..19615)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CO204_RS09785_PKS_KR.1"
                     /evalue="6.40E-10"
                     /label="CO204_RS09785_PKS_KR.1"
                     /locus_tag="CO204_RS09785"
                     /protein_end="159"
                     /protein_start="3"
                     /score="31.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LLTGITGVIGKSIFKSLVTKKHNIFGFYKGNEAAALELKELSRYA
                     KGNLFLFKGDSSDIYFLESSVEEIISTNGDIDLVIHNAGKNKDNFFLNMTMEEWHSVIN
                     TNLIANILLTQTILNYQSKQNFRILNVISVSAIYGREAQTNYSASKGGVVGY"
     CDS_motif       complement(19172..19219)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CO204_RS09785_0001"
                     /evalue="8.70E-03"
                     /label="PKSI-KR_m4"
                     /locus_tag="CO204_RS09785"
                     /protein_end="151"
                     /protein_start="135"
                     /score="8.6"
                     /tool="antismash"
                     /translation="SVSAIYGREAQTNYSA"
     gene            complement(19726..19995)
                     /locus_tag="CO204_RS09790"
                     /old_locus_tag="CO204_09740"
     CDS             complement(19726..19995)
                     /NRPS_PKS="Domain: PP-binding (21-65). E-value: 2.6e-09.
                     Score: 29.2. Matches aSDomain:
                     nrpspksdomains_CO204_RS09790_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263948.1"
                     /locus_tag="CO204_RS09790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09740"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_002263948.1"
                     /sec_met_domain="PP-binding (E-value: 1.3e-09, bitscore:
                     35.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQTDIKKIIKEKVLIERLELEDITPDEIIDSEPLFIDGLGLDSV
                     EALDVVAGVEEEFGVKVPKMMNEETQRYFHSVDSLAEYISTLLN"
     aSDomain        complement(19801..19932)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CO204_RS09790_PP-binding.1"
                     /evalue="2.60E-09"
                     /label="CO204_RS09790_PP-binding.1"
                     /locus_tag="CO204_RS09790"
                     /protein_end="65"
                     /protein_start="21"
                     /score="29.2"
                     /tool="antismash"
                     /translation="EDITPDEIIDSEPLFIDGLGLDSVEALDVVAGVEEEFGVKVPKM"
     gene            complement(20001..22094)
                     /locus_tag="CO204_RS09795"
                     /old_locus_tag="CO204_09745"
     CDS             complement(20001..22094)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (125-387). E-value:
                     3.4e-41. Score: 133.4. Matches aSDomain:
                     nrpspksdomains_CO204_RS09795_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     HR-T2PKS: ketoacyl-synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     HR-T2PKS: hr-t2pks-ksa"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263947.1"
                     /locus_tag="CO204_RS09795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09745"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_002269593.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 5.8e-22, bitscore:
                     75.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="hr-t2pks-ksa (E-value: 3.8e-81, bitscore:
                     269.9, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNTVVITGIGINSCLGANKKETLDYLLSDRSGITDLTIINTDEF
                     ETHVGGEVSVPNDREKERSLVLAEMAIGEAIVDSKLNEDMLTKAALLYGTCNGGICSIE
                     NCNIIEDISEDRLERYIFSQNADTLAKEFNIQGTVQTFNTACAASGLAIGTGYDLIKLG
                     RNDLIIAGGADAMSKAVYAGFSSLQSLSNQPCAPYDVNTGLSLGEGAAFLVLENKEHAL
                     KRGAHIYAELKGYGLSNDAHHPTAPDPKGGGVEKAVESALHNSEVNKEDIAYINTHGTG
                     TLANDGAELSGLKTIFGKAVLDSIAVSSSKSYFGHNLGAAAALELSSTLLLMERGYLPA
                     TLNHTETRQDCQGVNLIFNEKRSIKKGSQNILVNNSAFAGYNCSIVCSLYDDKKEVKSA
                     DVQQERKKIYINDYSYISEFYSVNLNGGKETFVDPFNLKGYKKHLYSRRMNTLSQYAIG
                     AVSNLSLFYLDNQSIDDIGFVFGTRYGSLESSAKYLSSIWNKGFDRASSIYFPDMVLNS
                     TGGKVHSALGFRGYASTISTGGNEFLATISDAYFALQSNVSGSLIAGSGEEKSNFEKYI
                     TTSITTEEWMASPYFECVEVSDCNDSWLEILDVYQGFVTADHLPNIIKEKLSECDVIIN
                     LSKSFLRIQQISEMAKGLEVIAYEELVSGVFEYISGSSYDEFSLIDITENGNCIILKLK
                     KGD"
     aSDomain        complement(20934..21719)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CO204_RS09795_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.40E-41"
                     /label="CO204_RS09795_PKS_KS.1"
                     /locus_tag="CO204_RS09795"
                     /protein_end="387"
                     /protein_start="125"
                     /score="133.4"
                     /tool="antismash"
                     /translation="ADTLAKEFNIQGTVQTFNTACAASGLAIGTGYDLIKLGRNDLIIA
                     GGADAMSKAVYAGFSSLQSLSNQPCAPYDVNTGLSLGEGAAFLVLENKEHALKRGAHIY
                     AELKGYGLSNDAHHPTAPDPKGGGVEKAVESALHNSEVNKEDIAYINTHGTGTLANDGA
                     ELSGLKTIFGKAVLDSIAVSSSKSYFGHNLGAAAALELSSTLLLMERGYLPATLNHTET
                     RQDCQGVNLIFNEKRSIKKGSQNILVNNSAFAGYNCSIVC"
     misc_feature    22336..22349
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.95"
                     /tool="antismash"
     gene            complement(22474..23394)
                     /locus_tag="CO204_RS09800"
                     /old_locus_tag="CO204_09750"
     CDS             complement(22474..23394)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033516.0"
                     /locus_tag="CO204_RS09800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09750"
                     /product="IS3 family transposase"
                     /protein_id="WP_106006836.1"
                     /transl_table=11
                     /translation="MRRGHLYQVVDRLKNRYPVSSLCSYFGFPRSSYYLWLSNGKPEYK
                     QFDSNLSQKVTDLFHDTQKGYRFICYQLRRPYQLFRNPKTILRYMRILGHHSPIRKKRY
                     HSCTQREITEKARHVHYNVLARNFKAERPLQKLTTDVSYVYYNYGRMLLSVIKDCYDNS
                     ILDYTLSDFNDNKLVFDNIDLVFNDFWDSTKVCILPSDQGFQYTNQQYLRKLDQYGVSI
                     SHSGKGNGYDNAACENFFSHLKSESLRPLPPKDKGTLISQIREYINWYNYHRPQEKLKG
                     MTLWNSGSHTLLNNTLFILSILDGT"
     gene            complement(23391..>23702)
                     /locus_tag="CO204_RS11000"
                     /old_locus_tag="CO204_09755"
                     /pseudo=""
     CDS             complement(23391..>23702)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002278791.1"
                     /locus_tag="CO204_RS11000"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09755"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KGSKFTKYSSEFKLQVVKDYLSGKSGGMPSIVKKYGLKSDNQGLT
                     WTRKYRKNPALLTQDLRGTKSTGRPKTRNLDEMSLEEQNAYLHMENTILKTLRTLLRK"
     gene            complement(23683..24998)
                     /locus_tag="CO204_RS09810"
                     /old_locus_tag="CO204_09760"
                     /pseudo=""
     CDS             complement(23683..24998)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008534445.1"
                     /locus_tag="CO204_RS09810"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09760"
                     /product="ISL3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLEPKNKKAKKNTTDLIGLKDKNIKITPSNPY"
     gene            25145..26321
                     /locus_tag="CO204_RS09815"
                     /old_locus_tag="CO204_09765"
                     /pseudo=""
     CDS             25145..26321
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611514.1"
                     /locus_tag="CO204_RS09815"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="CO204_09765"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKLTYEDKVQLYELRKL"
     misc_feature    complement(26367..26384)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            26728..27591
                     /locus_tag="CO204_RS09820"
                     /old_locus_tag="CO204_09770"
     CDS             26728..27591
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269812.1"
                     /locus_tag="CO204_RS09820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09770"
                     /product="Rgg/GadR/MutR family transcriptional regulator"
                     /protein_id="WP_002269812.1"
                     /sec_met_domain="TIGR01716 (E-value: 1.4e-51, bitscore:
                     172.1, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRAFELGELYKDLRIARGLKLKDVVHKNLSIAQLSRFENGLSML
                     SADKLLLAIEGIHMTFSEFGHALKNYEVSHFFKLTNRLSKLQSLSDIEGIQKILRTYES
                     FEIFDVYNRLNKLIIDVAIFTLDHKHYISDDDKEFLTTYLYSIEEWTEYELVLFGNTMV
                     ILSDEDLLFLGKSFVKRYKLYLSILSNKKATEKSLLNLILILIERKRYYHANYFIYRLE
                     EILTYQDMFARVTLTFFKLLVSYLQNEEKIDKTKLINYIKIVQELDNPILANFLKRNLE
                     ELTQNQ"
     gene            27712..28749
                     /locus_tag="CO204_RS09825"
                     /old_locus_tag="CO204_09775"
     CDS             27712..28749
                     /NRPS_PKS="Domain: NAD_binding_4 (14-196). E-value:
                     1.2e-19. Score: 62.3. Matches aSDomain:
                     nrpspksdomains_CO204_RS09825_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019777374.1"
                     /locus_tag="CO204_RS09825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09775"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_002265304.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.3e-10,
                     bitscore: 37.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.4e-13, bitscore:
                     46.7, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4.1e-18, bitscore:
                     62.3, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTTPSRTIKHAFVTGATGLLGNNLVRALLKKNIQVTALVRSMD
                     KAQKQFGNLPIRFVQGDILNPKSYQSYLSDCDSLFHTAAFFRDSHKGGKHWQELYDTNI
                     TGTRNLLQAAYDAGIRQMVHTSSIAVLKGQPNQLIDETMSRSPDTKIEYYRSKILSDQV
                     VRDFISKHPDIFITFVLPGSMYGPGDMGPTSTGQMILNYMQQRLPGIIKASYSVVDARD
                     VADIHIRAMKYGRNGERYLAAGQYMTMQEVVKTLEAVTSIPAPKRQISRPLLRAFAAWN
                     EIYHSITGKPVLVSKDLVELFAEEYQRTHFDHTKMEIELGGRFRPVEETMLDTINWYHN
                     NGYLN"
     misc_feature    complement(27741..27754)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.95"
                     /tool="antismash"
     aSDomain        27754..28299
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CO204_RS09825_NAD_binding_4.1"
                     /evalue="1.20E-19"
                     /label="CO204_RS09825_NAD_binding_4.1"
                     /locus_tag="CO204_RS09825"
                     /protein_end="196"
                     /protein_start="14"
                     /score="62.3"
                     /tool="antismash"
                     /translation="VTGATGLLGNNLVRALLKKNIQVTALVRSMDKAQKQFGNLPIRFV
                     QGDILNPKSYQSYLSDCDSLFHTAAFFRDSHKGGKHWQELYDTNITGTRNLLQAAYDAG
                     IRQMVHTSSIAVLKGQPNQLIDETMSRSPDTKIEYYRSKILSDQVVRDFISKHPDIFIT
                     FVLPGSMYGPGDMGPTSTG"
     gene            complement(28793..30036)
                     /locus_tag="CO204_RS09830"
                     /old_locus_tag="CO204_09780"
                     /pseudo=""
     CDS             complement(28793..30036)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373153.1"
                     /locus_tag="CO204_RS09830"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="CO204_09780"
                     /product="ISL3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEPINNTTLLIGIKDKHISLNEAIQQDTHTKIIATLDYHPPNGNT
                     ARENRLSMTSRNLLKFLSSKLVVPLDLSA"
     gene            complement(<30177..>30308)
                     /locus_tag="CO204_RS09835"
                     /old_locus_tag="CO204_09785"
                     /pseudo=""
     CDS             complement(<30177..30308)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011148688.1"
                     /locus_tag="CO204_RS09835"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="CO204_09785"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKGKNAFMMFDKHANLKYKFGNRHFWAEGYYVSTVGLNEATIKK"
     gene            30936..31175
                     /locus_tag="CO204_RS10680"
     CDS             30936..31175
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012870.4"
                     /locus_tag="CO204_RS10680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DDE-type integrase/transposase/recombinase"
                     /protein_id="WP_080271158.1"
                     /transl_table=11
                     /translation="MRRPNLINQRFQTKGKNEIWLEDFTYIPTKAGTLYLSVFIDVYMG
                     NRMQGQLVTDALNQAYHRERPKEGLIVHTDQGSQ"
     gene            31200..31319
                     /locus_tag="CO204_RS11005"
     CDS             31200..31319
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025063.4"
                     /locus_tag="CO204_RS11005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="integrase core domain-containing protein"
                     /protein_id="WP_353963810.1"
                     /transl_table=11
                     /translation="MRQKKCQSSMSRKGNPYDNALMESFYKTLKRGLYNICSG"
     gene            31416..32661
                     /locus_tag="CO204_RS09845"
                     /old_locus_tag="CO204_09795"
                     /pseudo=""
     CDS             31416..32661
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400088.1"
                     /locus_tag="CO204_RS09845"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="CO204_09795"
                     /product="ISL3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEHLKNTTDLIGLKDKNIKILFV"
     misc_feature    33246..33257
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.23"
                     /tool="antismash"
     gene            <33360..33896
                     /locus_tag="CO204_RS10770"
                     /old_locus_tag="CO204_09805"
                     /pseudo=""
     CDS             <33360..33896
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003101110.1"
                     /locus_tag="CO204_RS10770"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="CO204_09805"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKPDGVVYSFKNYSRQTDKYRFKHDFKIYEADKT"
     gene            complement(33967..35592)
                     /gene="treC"
                     /locus_tag="CO204_RS09860"
                     /old_locus_tag="CO204_09810"
     CDS             complement(33967..35592)
                     /EC_number="3.2.1.93"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008788 - alpha,alpha-phosphotrehalase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005991 - trehalose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257: Alpha-glucosidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002273487.1"
                     /locus_tag="CO204_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09810"
                     /product="alpha,alpha-phosphotrehalase"
                     /protein_id="WP_106006837.1"
                     /sec_met_domain="Alpha-amylase (E-value: 3.2e-89, bitscore:
                     296.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLDKRKVVYQIYPKSYKDTSGNGVGDLQGIIEKLPYLEELGIDV
                     IWLNPFYPSPQRDNGYDVSDYTAVNPLFGSMADFEELSRKGKEHGIEIMLDMVLNHCSI
                     EHEWFQKALAGDKYYQDFFILRDRPTDWVSKFGGNAWAPFGDTGKYYLHLYDVTQADLN
                     WRNPHVREELFKVVNFWRNRGVKGFRFDVINVIGKDEVLKDNPHFDGKPEYTDRPINHD
                     YLKMLNKASFGQDENGITVGEMSFTDIPNCIQYSNPDNHELDMIFNFHHLKVDYENGQK
                     WTRKTFDFEELKHLFHTWGEGMSQGNGWSALFWNNHDQPRALNRFVDIKQFRNEGATML
                     AASIHLSRGTPYIYMGEEIGMIDPDYGSMADYVDVESLNAYQELIDKGKSSEEAFHIIR
                     AKSRDNARTPMQWDASENAGFSTGRPWLKVGKSYPQINVANEKQGKIFPFYQKLIRLRK
                     EMPLIAQGSYQAALTDSDKIYAFEREYEGQKLLVLNNFFAETVELDLPSLYQTGEILIS
                     NYDDVELSAAITLKPYQTLAILQQ"
     gene            complement(35618..37585)
                     /gene="treP"
                     /locus_tag="CO204_RS09865"
                     /old_locus_tag="CO204_09815"
     CDS             complement(35618..37585)
                     /EC_number="2.7.1.201"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0015574 - trehalose transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0015771 - trehalose transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="treP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145: Glucose-specific phosphotransferase enzyme IIA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002283261.1"
                     /locus_tag="CO204_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09815"
                     /product="PTS system trehalose-specific EIIBC component"
                     /protein_id="WP_002265239.1"
                     /transl_table=11
                     /translation="MGKFEKDAKVLLDAIGGKENVSAVTHCATRMRFVLNDESKADVKT
                     IEAIPAVKGTFTNAGQFQIIIGNDVPLFYNDFTAVSGIEGVSKETAKSAAKSHQNPIQR
                     VMTLLAEIFTPIIPAIIVGGLILGFRNVIDQVQWGFLDGQTIAQHSQFWSGISSFLWLP
                     GEAIFQFLPVGIVWSVSRKMGTSQILGIVLGICLVSPQLLNAYNVASTPAAEIAKKWVW
                     DFGFFTVRRIGYQGQVIPALLAGLSLSYLEIFWRKKIPEVVSMIFVPFLSLIPALILAH
                     TVLGPIGWTIGQWISTIVYAGLTGPVKWLFGAIFGALYAPFVITGLHHMTNAIDTQLVA
                     DTGGTGLWPMIALSNIAQGSAVFAYYLMNRHEEREAQVSLPATISAYLGVTEPALFGVN
                     IKYVYPLVAGMIGSSIAGFLSVTFNVTANAIGIGGLPGILSIKVKYMLPFFIIMLVAIA
                     VPMVLTVFFRRINFLTKSEDEAHQEKTETAEISASEKTNEPAVGTTFEIKSPLKGQVKP
                     LSEAVDPVFAQGVMGQGVLIDPSEGLLTSPVNGVVSVLFPTKHAIGLVTDQGLELLIHI
                     GMDTVNLEGKGFETYVKQGDTIKVGDKLIRFDIDAIHQAGYTTETPVIVTNQNDYQPDV
                     VGSLPREIERGEVLLTASKI"
     gene            37759..38472
                     /gene="treR"
                     /locus_tag="CO204_RS09870"
                     /old_locus_tag="CO204_09820"
     CDS             37759..38472
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="treR"
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019805181.1"
                     /locus_tag="CO204_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09820"
                     /product="trehalose operon repressor"
                     /protein_id="WP_019313449.1"
                     /transl_table=11
                     /translation="MKKYKIIFKKLEEDILKGHYQMGDYLPPEMELSQIYASSRDTVRK
                     ALQLLTKAGFIKTVQGRGSQIIKRERINFPVSQLTSYQELVKQLQMNVKTNVIAIDKLI
                     IDEKLTKLTGFENKGLVWRITRQRVIDGVASILDTDYLDKALIPHMTREIAEHSIYDYL
                     ENQLKLDIAYAQKIITIDQVSQKDKILLDLDSENHVVSVKSKVYLSNQQQFQFTESRHK
                     LEKFRFVDFARRHRD"
     gene            38599..38736
                     /locus_tag="CO204_RS10775"
     CDS             38599..38736
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002279987.1"
                     /locus_tag="CO204_RS10775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002279987.1"
                     /transl_table=11
                     /translation="MAISRTPHLKWLEKTIKIAAFQDDFKELKVNIVRFLKENNRVINL
                     "
     gene            complement(38818..41370)
                     /gene="dexA"
                     /locus_tag="CO204_RS09875"
                     /old_locus_tag="CO204_09825"
     CDS             complement(38818..41370)
                     /EC_number="3.2.1.11"
                     /GO_function="GO:0033904 - dextranase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="dexA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011074684.1"
                     /locus_tag="CO204_RS09875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_09825"
                     /product="dextranase DexA"
                     /protein_id="WP_106006882.1"
                     /transl_table=11
                     /translation="MEQSNRQTAEPAIRSAETVDSTINSFQETDLKVQEKEDAAAAVQT
                     EPASIDSNEQGQSVSANTNTQPQAKKLSNNSHQEPMQMVSAANKERVVLETAQNQKNGN
                     MINLTTDKAVYQAGEAVHLNLTLNNTTSLAQNITATAEVYSLENKLKTLQYTKYLLPNE
                     SYTTQKGEFVIPANSLANNRGYLLKVNISDSQNNILEQGNRAIAVEDDWRTFPRYAAIG
                     GSQKDNNSVLTKNLPDYYRELEQMKNMNINSYFFYDVYKSATNPFPNVPKFDQSWNWWS
                     HSQVETDAVKALVNRVHQTGAVAMLYNMILAQNANETAVLPDTEYIYNYETGGYGQNGQ
                     VMTYSIDDKPLQYYYNPLSKSWQNYISNAMAQAMKTGGFDGWQGDTIGDNRVLSHNQKD
                     SRDIAHSFMLSDVYAEFLNKMKEKLPQYYLTLNDVNGENISKLANSKQDVIYNELWPFG
                     TSALGNRPQESYGDLKARVDQVRQATGKSLIVGAYMEEPKFDDNRVPLNGAARDVLASA
                     TYQTDAVLLTTAAIAAAGGYHMSLAALANPNDGGGVGVLETAYYPTQSLKVSKELNRKN
                     YHYQQFITAYENLLRDKVENDSAEPQTFTANGRQLSQDALGINGDQVWTYAKKGNDFRT
                     IQLLNLMGITSDWKNEDGYENNKTPDEQTNLLVTYPLTGVSMAEADRIAKQVYLTSPDD
                     WLQSSMISLATQVKTNENGDPVLYIQVPRLTLWDMIYINETIKPETPKVPEQPQHPART
                     LEPAIPQTPEAVSPLPVANKQAVDENKNEIVSALTGEENDLQLPTLSKRSLSISQAELP
                     QTGDNNETRSNLLKVIGAGALLIGAAGLLSLIKGRKKD"
ORIGIN
        1 catagcgaca actggaatac caagtttctt agcttcttta actgcaattt gttctttgtg
       61 cggatcaacg atgtagataa tatctggaat acgaggcata tcttcgatac cacccaagaa
      121 tttttcaaga cgcgcacgtt gcttattaag aagagcaact tcttttttag gaagaacatc
      181 aaaaatacca tcaacttcca tttgtttgat ttctttcaaa cgtgcgatac gtttttgaat
      241 tgtatcccag tttgtcaaag tcccacccaa ccagcggtgg ttgatatagt attgaccagc
      301 acgttctgcc tcttctttaa tcgcttcaga agcttgtttt ttcgtaccga caaacaagat
      361 aacagcatca tttgctgcag catcacgaac gaagtcgtaa gcttgatcag ctaattttac
      421 agtttgttga aggtcaataa cgtgaattcc attacgttct gtgaagatgt acttagccat
      481 cttaggattc caacgacgcg tttggtgacc aaagtgcaca ccagcctcga ggagttgttt
      541 cattgaaata actgccatga gtatttctcc ttttatgttt ttttgcctct ctcagacttc
      601 aacttgcaat ctaacccaaa aggcaacgag atcacaattc atctaagatg agtatttgct
      661 gcttacacag ctctattagc ataacaaaaa aattgaattt tgacaagtcc gtttgttatt
      721 actgcataca gattaaatac ttttttatta gcttattttt gctttagatt ttcatcaaca
      781 tactgtctga ttttcttcga acataggatg atagtttctc ctattttaga taaaaccatc
      841 cataattgct gtcgaacctt cctaggaagc caagctagaa tttctatagt gtatccaata
      901 cactgtacaa atgtcttttt gtaagctatt tgaacatgtc ctgaatgtga tacagaaatc
      961 gtagcaaaac cattatataa ggctttttct gtcaccttag gttttttggc cttagaatat
     1021 tgagctagct cttctttcga taatttttga tagattattt taggctgtgt tccgacagct
     1081 tcgtcgctat agtacgcttt ataaccctta taccaaattc tcggtacaac aattgtctga
     1141 ggttgattgc ttttaagcga aacatcaaat tctaaatcat tatatttttg ccgaacattc
     1201 tcaatagcta cctcctgctg attataaaga aactgattga ggcttaaacc atttcgcata
     1261 tcatcatggt tgacagaaag attgagatac tcatctccac tagtatcata agatagctga
     1321 agcggatttt taaatgcctt tacagcaaag gtattggtgt tttttaaata ttctatactt
     1381 tctcgatatt cttcataact atatttataa ggctgtgtta ctatataata accaaattga
     1441 aagatacaga ttgaaataac aaggtattta ttaaaagaaa tacacgctgc catcaagacg
     1501 tatattggaa gaaaatacac caatctattt gtatattgaa aaacacctaa aaaactatac
     1561 tttaatattt tccacggaat taatgttgtg gttgagaaaa gcaataagag tgacatcaaa
     1621 ataagctttc gagaaacgct tttaatccaa aaactagata ccaatcctat aacgataata
     1681 actatggcaa ttggaaattg atagttgata atagcatctc caacactatt tggaagcatt
     1741 aaaatcttag ctggaaatgg aaaatctctt attatccaag atacaaaaaa agtttgagat
     1801 tgagtttgct ctacatattg aaaaatatag ccactagtca taataagacc tataactaaa
     1861 gacagggaga atgaaaaaag tttttgtcgt gttagctggt tactatttaa taatacaaat
     1921 atagcagaag caattcctag tactattgtt gatatcacgt gtgtttgaat gagcaaagat
     1981 ataactgccg ctagcaacat aggattgtag cgttcactat atatgacctt atacaggcta
     2041 taaaataata atggtatcaa aggaatagca gccaccatcc catatccaaa aaatggtatg
     2101 gtaataggca gtatcaaggc aaaaataaaa gctcgctttc tacttttact catctgatat
     2161 aaggaataaa aacctgtcag agaggaactg tagatgagca gaaaagcata cactgagtat
     2221 gcaaacgtgg ccgtttttgt tgctaaaaat acaagggccg gaatataaag ctgccaattc
     2281 ccataaaaca tggttacagc atagccagag ttattagcta ttacataatt taaattaggg
     2341 agccagtctc cattttttag agattgagcc aagccgacta ttctagacat atgaaacgaa
     2401 taatcataca tccagctacc gcggtttata gaaatatatg atatataagt tattattatg
     2461 gcatagatta aaaaaacaat actatatgat aaataactgc taagcattaa agaatcgtca
     2521 ttggaatcgt tacctgaatt tttaatttct ttattgcttt ttaaattatc taaaaaacgt
     2581 aaccgaagat cttttatcat ttttctccat tagatcgctg taacattctc ttcataactt
     2641 tatatttttt atgcagatga ttgccaacct ttcaatcgat ttccttatcc gcatcttgtt
     2701 aaagaattaa cttctaatat tatagcacat tataaaaatt aaaaatgctt attttagatt
     2761 ttatctggtt ttttacctgt ataattataa ccgcatttac cctatcagca attaagacgg
     2821 tagtgatagg aaaaaacttg acctgactga ttttttaagg taaaataagg aatgttatgg
     2881 cggtatagcc aagtggtaag gcacggctct gcaaaagctt gatcgtcggt tcaaatccgt
     2941 ctaccgcctt ttgtaaaaaa tctcctagtc caactagggg attttttgta tcgaaacgaa
     3001 atattttaaa ataattgtta tttttgtcct caaacagtaa tcaaaatgat aaaataagta
     3061 atagaaagat gttactgtaa acaagcctat tttaagctct acagaattca agattatttc
     3121 ttttattagc gaacggaata agctttaaaa gaggcttctc gctgtgagaa aaggtgacag
     3181 aaccgttgat gtttctgcca cttggaagag tttcaaatct taggtatgga atttcaaaag
     3241 aagtcgctac tgttcttatc atctaaggaa agccttaaaa gaagattttc ttgaatctgt
     3301 atagagacct tttaatactg ttgaaaaaca ttgctaacaa taacctagaa aaaatgtcac
     3361 atttagggga ttacttatgg agaggaaaag atgaatgaaa aaactaacat atggtgatca
     3421 tatcagagtg cttagtccat caaattctat tgaaagttta ggtggattca atgccaattt
     3481 atcggctaag agaagacttg aaaagttagg ctttacagtt tctttttcta ataactatat
     3541 ggaaaatgat ctgctcaatt ccagttctat cgccagccgt gtttctgata tccatgacgc
     3601 tttcagagaa gaacatgtca atgccattct ctcaacaatc ggtggtttta atgctaatga
     3661 aatcttacct tatttggact ataaactcat taaaagtcac cctaaaatta tctgtggtta
     3721 ttcagataca acggctcttt taaatgcgat ttatgccaaa actggaatgg aaacttacat
     3781 gggaccgtct tactctagtt ttaagatgga agaaggtcag gactatcaaa gtagaatgtg
     3841 gctaaatgcc gttactagac acgtttacaa cttagtccct agtgataaat ggtccagcga
     3901 cccttggtac gatcctagcc aaccacgtca ttttatgcct acagaatgga aaatttataa
     3961 taatggcaag gctgaaggga tagccatcgg cggccattta gccacctttg gtcttctacg
     4021 tggaactgaa tttgctccta atcctgaaaa ttatatcctt ttcttagagg gatctgaaga
     4081 agaaaagcct accgaaattt ctcgccattt agctgctgtc ctacaaacct atcctaatcc
     4141 tcaagccgtt atttttggac gttttccaaa agagtgtcaa atgaccgaga aaatttggca
     4201 tttcatcctt gataaacatc ctgttctaaa acaaattcca gtcatgtatg accttgattt
     4261 tgctcataca cagcctttgt ttacctttac tatcggcgct aaggtcacta ttgataccat
     4321 ttccagagct attcaattta aaacaacata aattaagatt gaattagaat aaattttgtc
     4381 taatcggtta tctagtcaat gaaaaaacgc ttgaattaaa attttcaagc gttttatttt
     4441 agattgttta atataataaa gcgagttaac acatcataaa atataaacta gatatctacc
     4501 aaataataac acgtttatct tcatcacgcc acatgccatc accttcttta accgcaaatt
     4561 cttggtggaa ttcgtcaaag ttggtaactg taacattggt ccgccattta gctggagcat
     4621 gaacgtcaat acttgctagc atttgcatat attcgtcgcg tgctttcatg cgccagatcg
     4681 ttgcaaaatt aataaagaaa tcacggacag aaaaatctgc ttcacgtttg gcagcttcaa
     4741 gagcacaggc aaggccacca agatcagcca cattttccga aacagttagc tgaccgttga
     4801 ccttagcacc ataagaatca agtccttcaa actgttcaac aacctgatcc gtacgttcct
     4861 taaaggctgc ataatcttca tcagcccacc agttattaag actgccattt tcatcaaagg
     4921 aagcgccatt cgtatcaaaa gcgtgagaga tttcatgggc aatgacagca ccaatgccac
     4981 cgtaattagc agatgaagat tgctccaatg aataaaatgg tgcctgcaaa atagccgctg
     5041 gaaagacaat ttgattttgc tgcggatcat agtaagcatt aaccatatga gctggcatat
     5101 gccattcact gcgatcaact ggttgattcc acttactcca attataggca attgagattt
     5161 tagccaaatt ttgagcattt tccactagac tgagattgtc gtcaataatc ttttgagcat
     5221 aagtcttggg taattgttct ggataaccaa tatgaggcgt tatgacattg agtttggtaa
     5281 tagccttatt acgcgtttct tgagccaacc agtccgtctt atgcaaacgt tctttataaa
     5341 cctcaatcat agttgccact ttagcttcca catctttctt tgcttcaaga gaaaatttct
     5401 cgccagcgta ccaaagaccg agtgcttgat tataagggcc ctgagccaga taaaaagcgg
     5461 cttttttctt atccatagct tgaggtgtcc ctgaaagagc acgattatag cttcctgaaa
     5521 ggatacgaat atcatctgtc aggtaagaat tgtaagaact tgctgcagct aaaactaagg
     5581 tagcttttaa gaaaggccaa tttttttctg aataaaattc aactgcaaaa tttgtccaaa
     5641 aacgctcttc aggaacgata actttatctg gtttttgacc taaaatctgt gtaaaaatcg
     5701 catctaaagg cagttctggt gttaatttgg taaaatcagc ccaatcataa ggatgataaa
     5761 gcttcacata ttctgatgat tcctcactgg aaagaacata ttgagccaat ttggcatcta
     5821 aagtaagcac cttatctaga agatctttaa tttctgcttc ttcaaaacca aacttaggca
     5881 aaagttcctc ttgcattgca cgccacttgg caagcagttc cttacctttg tcattacctt
     5941 caacataata agtggtatct ggtaaaataa gatttggagc ctcggcccaa agcacattca
     6001 tttgtgcatt cataaaatcc ggtgccacac caaaaggaag ctcattaggc ttgccagcca
     6061 tttcataagt ggctatgttg gaagcaaaat cagcaaaaga agttagactc ttatattctt
     6121 caatgagagg cagcactggc ttaacacccg tctcttcacg cgcatcatag tccgccacct
     6181 gacgatggaa cttcacaaaa ttttgtaaaa tactatcatc aggaacatct ttcccatcta
     6241 gccacttgtc agtagtttct aacattaaat cttcaatatc atcagccaag tcagaaaagc
     6301 cacccgtccg tggtttatca tcaggaatga ccgctgcctc ttcccactgg ccattgactg
     6361 cgttataaaa atcatcttgt aaacgtacca taactattct ccatttctat acgctttcta
     6421 ttgtaacaaa aaagtccgat ttaagcagtg tcggactttg aagttttttt ctttgctaga
     6481 tactaaccaa tgccttcaca ttagcaactt gcttaccttc aagaaatgaa gttttccaaa
     6541 agaaaagaaa gccaaaaaat ctaaacattc atcatgcttg tcaacgttta gatttcttcg
     6601 cttgtttaag cgctatctat catcaagaca aactgaaaat gaggctttaa aacaattatc
     6661 actgatataa attatctcta taactcagag ttcttgaaaa acggatgaca tattattaat
     6721 aatggcatct ttaaacattt atagaaataa aatgcaccca taccctattt ttctcattta
     6781 acaattataa gaccattttc ctaaggtgac ggatttgtaa tgaggtaaag atcaaaacta
     6841 tcactactgt ataggcaccc agtttaaacc attcaagatt tgtaatctct ggattaacag
     6901 aggtcatatg attcatagaa gcagccaact tagaaaaagg taagatatag cctaattcag
     6961 gaataatatt ttgagctgtc aagataaaac caaatatccc gattatcata gacaaagcat
     7021 cctcagctgt aaaatcaata aagagttctt caagagactt ggttacttcg taaatacgat
     7081 agatagccac atcagcctcc aataagcgtt taacagtcag cgctacttgc tcatccgata
     7141 aatatgatag aagtaagcct tgatcagttg cctttacatc attaggatca aggtctaata
     7201 aggatactgc taacatatcg tctgaggttc tcagacaaat gctgcggctg tattggctct
     7261 tgaattgctc aacagtccct tgatacagaa gcttgccttt accaatgatc cctattagag
     7321 tcaccatttt ttcgatctcg tccagagcat gtgaagaaat cattacagtt gtattaaaag
     7381 ttgcaggcag gatgcggatg agcttgcgga tttcttcacg cgcctgcgga tccaaaccat
     7441 ttgtaggctc atcaagtata atcaatttag gatgccccat aattgccatg gcaattccta
     7501 aacgctgctt cattcctaaa gaataatatt tgacttgctt gtctttgttc tctgtcagat
     7561 gaactatggt taacacctct gctacatctt gatcggtcaa atttttcaac tctttaagaa
     7621 tctgcaaatt ctcatatccc gttaaattat cataataggc aggctcctca ataagagaac
     7681 caatctgctt caaaatagca atacgattat tttccttcat cgcagaaccc gcaacattaa
     7741 tctgccccgc tgtaggtgtc agaagtccgc aaatcatttt catgatggtg gattttccgg
     7801 caccatttgg accaatcagg ccataaattt ctccctgctc aatttttaaa ttgttgagat
     7861 caacagcagt ttgttctcca aaaacttttt tgacttggtt aagttccatc atctttttct
     7921 tcatcacatc cattcctttc ttcaacttat gtaaagagtg caactaaaat aagaatgtgc
     7981 aagtaagata ttctatcaag ctaagtagca ttatattaaa aatcacgttc taactaactt
     8041 acagtttagt aagtattcaa gctatttcaa gggtaatgcc tttgttttca ggagcgcaac
     8101 aacggccttg ctcctcttga aatgaggaac aaggccgttg cttaatcttt tattatttta
     8161 gtgtccactt gacagagagc agttcagtta ggcattcaat cactgatttc tttttttaat
     8221 gagccatatt attaggagaa aaatcaataa atcagaaata taatatgaat cccaaagtcc
     8281 tgaaatatta aatattaatg gcaaaaaaac agccaaagga atttgaaaaa taatttgtcg
     8341 taaaataact aaaattgtcg agactcttgg ttgagagata tattgaaaat aatttgtgcc
     8401 gatattaata atcccttgta aaggaagaga gagcataaca atccttaaag cactacttgt
     8461 aaaggccacg aaactcttgc tatcagaatt aaataaactt acaatctctt tagaatatag
     8521 ctgaataatt acaaaaagaa atattgaaaa tagagtccca accgttagtg agctcctaag
     8581 actcttttgt actctaacac tattttgagc accataatta aaacttatga tcggctgtat
     8641 accattagta attgcattca ttaaagaaat aatgtaacga taaattgatg aaacaataga
     8701 aagagctgcc actccataag cactcgcgta ggctaatgca actctattat acaaaattag
     8761 cagtaagacc gaaattatcg ttgttaagaa aaaaggtagc cccatattaa tgattctttt
     8821 tgctcttttt aataatgtct tactatcagg aaaaaagaat tttaatttta agttggaaga
     8881 tgtttttaaa tatgtataac aggtcattac taagattgtc aaatttgcta aaatagtcga
     8941 taaagctgaa ccagtaaaac ccatatgaaa tattaaaata aagatacccc ctgttcccgt
     9001 gttgacaaca aaggatatta agttaatata aagtacctct tttactgcac cttgggctct
     9061 tacacaacta agaagagtat gtgatacaaa atacacagga gaacctataa ggaataccga
     9121 agtaaactcc caaataaaat gatataaaat actaggagtt ccaaagattc ttaataagta
     9181 atctaatcct ccccaaatca gtatactttg aataaccgat aagataagcg ataataaaac
     9241 tgagatactt agaacttcct cagctttctt gtatttagct tccccaagta taattgttaa
     9301 taatgaagct gttccctcgc ttgctaaagc agaaaagctg taaatcaaag tgtatatcat
     9361 gaatatgtat acattagctg aagttccagc aattcccaag gactggccta taaaaatgcc
     9421 atctacaaga ttatatgaac ctgtcactag tgctgtcact aatgaaggaa tcataagttg
     9481 tattaagaga ttttttatag actctttttc taatttattc atctaatctt tctcttattt
     9541 ctttaaagaa aattctattt ttaaatattc tacctaacat atatcccttt aagcaacact
     9601 cattattttg ataaagtgca aaaacataat aacccgagta ttttcttgtt ttaccagaaa
     9661 ttacctgtat caacaaagga tgctctaggc taacaaactt cttataaact ttatattcct
     9721 ctgtcggaat catataatgc atttcaccct ttaatgccac ttcagaagta gctaagcagg
     9781 cttgtctaca aatctcagcc aacaagattg actccacatg gtcttttgct tcatgatcta
     9841 aaattatttc acctgtttta aaataccctc gtaaataaaa gacattagtt ccccctattc
     9901 tctcactttt tgaaaccata atatttttat tacttatttt atgaacgaga gcttgatctg
     9961 ccttcgaact agaggagagc aaaatattgc tatatttcaa aggaatccct atcctatcac
    10021 ataaagccat aatttgtttc ggtgtagcct tttttaagtt ttgcttaaca tcttcatagg
    10081 ttttattttt taaccactga aaaaaatcac tattatcgtt aaaatctggt aaatatattg
    10141 aaacagactg tttcaatatt gataaaattt gttttatctc ttcaatatca gatgagatta
    10201 taatacttga ttttaaagca tctacctgtt ctttctttct tttacagata gtaaaatcat
    10261 tatcgaaatt atcttgtaga atactcctca taataataca cactcacttt ataattttag
    10321 cactgggaaa ctgtttacca aattgattta tctaaatcaa ccttctccag ataatttttt
    10381 gtaatctctt ttacagagtg aacaatatat ttgacacctg tttttttcat ctcttcttcc
    10441 tgaaatcccc atgaatgttg agccggaaca ccaataaacg gagaaccata ctttttagct
    10501 tcttctgcaa ctctattaac atcatcaata aataaaactt gcgaaaaatc aaaatggtat
    10561 ttagtaacaa tctcttttag cccggggcgg aagtcattcg tacatatata acaatcaaaa
    10621 tactttaagt aaggcttaaa tataggatca atcatcttct catctaagcc tccataacat
    10681 acgagtgata catttaaaga ttttaatagt tgtaagaatt caggaacacc agagagaata
    10741 ggacttctat catatttaat aaattcagtt cgttcttcaa aatattcttt taaaagttcc
    10801 tgaacagaaa tatttttagg taggcataaa ttattcttta catagcttgc tgcttctgac
    10861 ctattttgag aaaatgtatt attctctaaa tcagctgtat aagggatacc atatttctta
    10921 gcaagcctat gtagaatagg gctaaaagta tcttttagta gtacgccatc aatgtcacaa
    10981 gcaattaatt tcaaattttc cattatttct ccttatatta tattgagcgc aattataatt
    11041 aataaactta aagttaacaa ttcaacaaat tagttggtct ttctatataa attcacttga
    11101 ttttgaagct gttttgtacc tgtctcataa tagcattgaa aagtaccggc caagcatttg
    11161 ttgtaaattt agtatctttt ccgtgagcta accgcctcat ttgctgttta taatatgaca
    11221 agccaacaat actaccaatt ttatcatcaa accgtcttat ttttgttgat aaacgtggta
    11281 aattaaccaa attacaagat cctgtagaaa tttggtttgg taactcagga ttcataacta
    11341 atgcccttcc taaaccaacc attgctatac cttcactgga aacgacctcc tccatcacct
    11401 ttgtatgtgt taacccacct gtcagaatta ctggaaattt tacttgtttt tgtatttttt
    11461 tagcaaattc gagaaaaaat aattctttat tcttggattc tataatttta cttttttcgt
    11521 aattactacc tgagatttca acaaaatcaa tgcctaattc tgccattttt aaaatgactt
    11581 ggtaagagtc ttctctatta aaaccctttt ctgtaaaatc cgatgaatta atttttaaac
    11641 ctatgataaa atctggcgaa gtgacctctc ttagtccttg ataaatttca attaaaattc
    11701 gcattcggtt ttctagatta ccaccatatt gatccgttcg ttgattatcc acaggagaaa
    11761 gaaattgatt aattaaatat ccatgagctg catgaatttg aacacctgaa aaaccagctt
    11821 tttgagctat tttcccaaca ttgataaatt tttgaataat gtcctgaatt tcttctatta
    11881 atagagctct aggtgtatta aaagcccctc gtaatttttt cattattgga atagcactag
    11941 gagcaacagg ttcctttgtc ataactttag gtgtttgttt cccaggatga ttaatctgca
    12001 atacgaaaca tgtattattt tcagtcccag catttgccaa agaccttaat ttatctaggt
    12061 ttgtatcatc atctatcaca agattcccag gactacttaa gtgctttcta tcaaccttaa
    12121 cattcccaga aattagtagc ccaacacccc cgtttgccca acgcttataa agttgaataa
    12181 gctcatcagt aggttgatta tgattatctg ctaatccttc acccatggca gatttcacca
    12241 tacgattttt tatttttcta ccattaggta aagtaatttc tgataaaagt aacatttttc
    12301 ccctttcttg ttatagtaag tttttaatag atcaaacatc tatgattgta agaaacgaca
    12361 tcaacaattt tttatgaagg ttaacgataa ctagtctata atgtcatata catagtataa
    12421 gatatttaat actggcatta ttgttattta attattcaaa aacagttatt tagaaaaaga
    12481 gaattaatta aatgaaagta tgaaatactt aatttgccat aattaatttt cattaataaa
    12541 aattaacgaa cttatatatg agtattctta tattttattc tgatttagaa ctaacttatg
    12601 gacattgtac ccactccaaa tcaccccact atatcctgat gacggtttag tccatgctcc
    12661 tgaaaaatac aagcccttaa ccggagtttg attatctaac cgtctattca aagtttgatt
    12721 aacaacttgt gcacttccat aaatagctcc tctaggatta ctagtaaatc tcatattagt
    12781 aagtggagaa cctgaaactt tctcaacaat atactcggaa aaaccactaa aaatggtatc
    12841 cattttttga attagtcctt tctcccacct ttctttctta gttctatatg tctttctatc
    12901 aaccctattc caattagcga attggctgac agtacataat gacacaatgg tatatttccc
    12961 cttcgaatct ttataaatag agcaattgat aggtaaatca gatatatttt cacttttcaa
    13021 attttcccaa aaagagtttg cttttgagtt gtttaaaaaa aattcgtgtc ctccctttgc
    13081 ataactatat agttcataaa aatcacgatt taaggtaata taaactacaa aactagagca
    13141 acttggaatg atattatcaa ttttctttaa atacctcttt ggaaaatttt cttcatttgc
    13201 aagtctaatc gttgcagtcg gacttatatt agaaattaca atatcactaa aatattgctt
    13261 ttttctacat tccactccca caacttcact atctttaatc ataatttttt taacttctga
    13321 acctgtaatt acctccccgt tattatctat aattattgtt ttgaaagctt cggaaattgc
    13381 cttggagcct ccttctggat aatacgaacc atgaatcata tattcagtcc atacgtaggc
    13441 ataaattacc cctccaagct cttgaggtgg caatgagaaa taaacccagt acctagaaaa
    13501 ttcttcaata agtgcttggt tatctgtaat cgtagatagc aaatgatgca aagaagaatc
    13561 tttatacttt aaaattgtag gtatattatc tttaaggtta gttaatggtt ctttttctga
    13621 aaaactgttt aagtaattca tttcttttct gatagttttg aataagttta ttatagtatg
    13681 gatttctctt tcgttttctg aataattaag ttttaacttc ttagtgaaat catctattcc
    13741 atttatagaa gaaattatac cgttttcatt aacaattgaa taattagaaa cttgtttttt
    13801 aaatataacc ttttcaaata attctatttc acttaaaact ttatacagtg aaccatcatt
    13861 atccaaatct ccaatagaat gtaatgaaat ttcatattcc tctttttttc tagagaaaga
    13921 gtacgcatag ccacctattt gtctcatttt ttctaaaact aatacttttt ttcctgcttt
    13981 agatagaaag gctgccgaag acagacctcc aagtcctgaa cctataataa taacgtcata
    14041 cataaattca atccttccat tatttatact tcattataaa tcattaagta aataatttta
    14101 tctatttgca aatacgagca aatatagtat aaaataatca tatttacaat tttctaaccc
    14161 ccaaaagaat aagtatcact cattactaac tttacagcta aattcaaaca tattcatata
    14221 tataattcta cgagagtctc tttttctgtt atttttttcg accaaggttt taaggtatta
    14281 tacaaattgc tgttatgaaa atagttcata gctgatttac ctttatagaa attatcagta
    14341 atttttcaga tcaagaacta aatattttct taacaatagc accttctatt attaagagtt
    14401 aaactttatt aaactggtag agtgaacaac atgattttta cgattggcac ttcactaaaa
    14461 ccagtcgcaa tcaaattaac tttaccttcc taatttgcta tatcaccaaa ccaacagcat
    14521 aaataccttc tcaactagtt tcgaaagaag acaagatctg aatacttgaa cgtctgtaat
    14581 ctactcccaa gtccttaaga ttcttattaa aagttgaaaa aacaaaacta ataatcaaaa
    14641 catctaagcc aaaatcaata acattgtctg acttaacatt tcgaattatt aaattagtga
    14701 ccttttgact attccttatt atttccaagg gaacataggg agtcataata tcaacagaag
    14761 atgctttaag caatccaaca ctatactcat gggcacgaat gttttacgac ggtgaatcaa
    14821 acctacattt ttagcaattg attctaaata taagcccaat caacagccga atcaccacca
    14881 caaataacaa cgttttcccc tacaaattaa tctaattgat aaatattata taaaaaatgt
    14941 tcttttccat ataacgctct tctcacttta cctctaaggt tcgagagagc aaagaattat
    15001 taccaattat aatagcacga ctcatatgat gcttcttatt cgttataata atgaaggtat
    15061 tattattttc gggataaagc actgcagggt aaccacccaa ttcaggcaag gattcaataa
    15121 tcttaatttt cattcctctc aaacctgcat aaaaagcggt ataaagtcca actggaccac
    15181 ctccaataat agtgaggcca tatatttctt ttcttagatt aatcataatg gccttttcac
    15241 atatctttat ctaatcttat gtttctcacc tttatatatt ttaattttca ttatttatac
    15301 tacttctaat aattacactt ataatataat tttcataaat aaaacttctt gcacgataac
    15361 catctgataa ctttaagcct tgcttagtta gcaagacatc ggattcaggt ataaaactca
    15421 agccaattcc tttacatttc accatggctt cctttaaaga ccacagccga ccgaataact
    15481 ctgattggtc tttagtctcc tttaaataag caatttcttt gaggttaaaa aaatgtccta
    15541 gaactgagga attatatttt acaggtaaag tcaaggattc aatatcaacc ccaattggag
    15601 aagctgaaag tcctataact aaaatatcat ccttattcga aacattaaac tcaaaaatat
    15661 cagggataac aaagggcttt ccatagaatc cccgtgaaaa atctagagtc ttattcttat
    15721 aaatctgttt taaaatcttt tcccatagtt tattttttcc agacgagaaa aacgaattat
    15781 acttaatatc aaattttctg aaatcaaata atagaacaca atctcttcca ttaattaatt
    15841 ttagattcaa taaaaaattt gagaattcct tttgcgactt tattattttg atcatcagat
    15901 atctcacatt ccgttatgac aaaatttcca aaaactcttt taaaatgaac tctagatatt
    15961 aaaattgttc caggtcttac taactcactg aaagtaaatt tttctacgtt cgccaagtaa
    16021 ccattattag cttcaagacc caatttctca aagtctaaga acatactgga ttgggcagca
    16081 aattcaataa tcaaaacacc agggaaaacg ggatcctctg gaaaatgtcc ttgtagatag
    16141 gcggcatttt ctgatacaaa tttttcacaa gtaacctcat cttcatcagc tttaataact
    16201 ctatctacca ttaaaaacgg aggcctttgt ttcaatttct ttctaacatc attcatagtg
    16261 cttctcccac tttcctatat tattgataat tttttcttcc aattacacga aagcattaaa
    16321 agtaattcta tagctgataa agccgttaaa gttaagtaca atggaagata caattaattt
    16381 cttcattaat aatcactact attactcctt ttgaaaatca cgtaagcgac atatagcagt
    16441 ccactagaaa cttacataac actagtatac ttctctgatt tttttaaata ttctaccaaa
    16501 ttgaagcttg acaaaatagc cgacactatc cctccaccat tattggtcca atgaccagtg
    16561 aagtaaagct tatctagagg cgtagcaaaa ttagggcgct gaaaaatctg ctcttttttt
    16621 tgttcccaac caaaaggaga acctccacta ttttgtgtat atctctccat cgtttcaggc
    16681 gtcccacttt cttgaaacaa gatatgcttt ttaagatcac caataacatg gcttgcttct
    16741 ttaattaagg catcttcaaa tacctttttc ctattcttcc accccccatc aacagagtaa
    16801 ggaacaaaag tagatagcac tagaagtgtt gaattatcca cagttagcga tccatcaatc
    16861 aaactgggag ctgaaattga aaaactactg atatctgctt ctaaatttga gaaactactc
    16921 ctgatatcac tgttagagcg atctgcaaaa taaaaatttt catgtgctag gtcaagttgc
    16981 tcttttttta aatctgtagc taagtaagtc tggaatactg aaaaaggtaa agtcagcttt
    17041 ttcaatttag atagatatcg ctttggaaaa taaatttcac caactagatt ctccacagtt
    17101 ttgagaatat ctcccgatgc gataatccct tttctagctg agacactcat atgttttctt
    17161 tttaaaacta aaccagatgc acttccctct tcgatattta tagctataac ttctgctctg
    17221 tatactaaat ccccaccgtt ctcttgaaat tttttagtaa gtgcttcagt taaagtgtca
    17281 aaagaacctt taacatagta ggccttctct atgaaaaaag ataaaatagc ataagaataa
    17341 tagatagctg aagcatcttc aggtattgtt ccaaagaacc cccatagtgt agaaatagcc
    17401 aatttgagat tgttattttc tgtaaattga tttaataact cagaaaaact atcatcacga
    17461 tatttattga tatactgtgc atccaagatg ctcctctcat ttttttgaac gctaagaaca
    17521 tcataataga cagatttcat ttcatcgata attgcatcaa catcttgttt atttttggga
    17581 aaagtcgctt ttagattggc cttaaatgcc tcaagatccc ttcctgaatt aaaggaaaaa
    17641 ttaggtgtga ttgttttata aatatcatcc aattcaatga aaaagtccct atttttaatt
    17701 tctaaactgt caagtaaatc tgctaataaa ccgtgtttag ctccagcaac aatccttaca
    17761 gccgaatcaa aggtatatat tttttttcta gaaaaagaat gaacatatcc accggcctta
    17821 ttatgctttt cacaaatcaa aacttgatat ccctgaccac tcaaataaat acccgcagcc
    17881 agaccactca ttcctgctcc tactataata taatcatact cagtttttat atttgatttc
    17941 atcttacctc ccactaaaag ctctgatttt ctatcattct cttcaattcc ttaaaattta
    18001 gatagctttt atatcatcta atacaaatta ttaaatgaaa gaaccaattt tacccgatgc
    18061 ttaacagttc ttcaacgcct caaattaaat aatagggtaa aatttacatc atcacattta
    18121 ccgataaata ttataaagta attcccaaaa acccttgtct gtgatcaatt tactatagct
    18181 tcatacgatt tcatatgata atatacccaa aaggaagtaa attggggata taccttatca
    18241 taaatccttc aaattgttgt atccgttccc ggggacagct caacattctg accacttagt
    18301 atagactttc cattatatat ccccatcagc tcaacaacct cagctacttc ttctattttt
    18361 ctcaagctag gcttcagatt aaagattttc atattctctt tctgtaactg cttaaagtag
    18421 aaacctgcgc ccaatgttaa tgcattaaca ctaatactaa aggatgatag ctccttagat
    18481 agacttttta ccaaggacag aactaagttg ttatatatcg gagaagacac tacaccatga
    18541 tatcgaagta cgtcgtactt caagagaaaa aggatattcg tatttttccc tcgcatcata
    18601 ttggcactaa ctgtctgatt aaagctaaac agctgatcta agaagggttg taatttattc
    18661 agacagtaat ctttgtaatt ttgttcaatt aaaaacgatt catcttcatc tataatccca
    18721 ttaatgaaga tatcaatcct gtttctcaaa tcatcaaaga aacgattata ctctcctttt
    18781 tccccatcag tcaaacaaca gatatccgct acgcatataa cttggtgtcc catttttttt
    18841 aaggagctcg ccaatttcct atttacttca tactttgttt gtgtaatgat aatattcata
    18901 cttacctcat aaaaccacca tcaattttta tggtcatatt tgtcatatat ctagatgtca
    18961 tgtgagcaaa ataatctaca aactctgcta tatcatcagc acttccgaga caccttttac
    19021 ttgtataatc caagaaattt tccaaacttt tttttggtac cccatccacc atagaggagg
    19081 ctatcattcc tggggcaata ttaacaatct ggatatcgct gccttttctc gttgacagta
    19141 gctttgaata gccaactacc ccacctttag aagctgaata atttgtttgt gcctctctgc
    19201 catatatcgc tgaaactgaa ataacattaa ggatacgaaa attctgttta ctttgataat
    19261 tcaaaatagt ctgtgtcaat aaaatatttg caatcaaatt agtattaata accgaatgcc
    19321 attcttccat cgtcatatta agaaaaaagt tatctttgtt ttttccagca ttatgaataa
    19381 ctaaatcaat atcaccatta gtagagataa tctcttcaac actactttct agaaaataaa
    19441 tatcagaact atcccccttg aacagaaaca aatttccttt agcatagcgg gaaagttcct
    19501 ttagttctaa agcagcagcc tcgtttcctt tataaaaacc aaaaatatta tgtttcttag
    19561 taacgagact tttaaaaata ctttttccta taactccagt aattcctgtt aatagtatat
    19621 tcattgcact ctccattaaa atatttatta gaatacaata tagaggtgaa gaggacaata
    19681 actcttaccc ccattttgaa aacataaaca tttactacat atagcttagt ttagcaaagt
    19741 cgaaatatat tctgccaagc tatcaacaga atgaaaatac ctttgagttt cttcattcat
    19801 cattttaggt accttaactc caaattcttc ttctactccg gcgacaacat ctaatgcttc
    19861 tactgaatct agccccagtc catcaataaa aagaggttca ctatcaataa tttcatccgg
    19921 tgtaatatct tctaactcta accgttcaat taatactttt tccttaataa tttttttaat
    19981 atctgtttga tccattttac ttagtctcct ttttttagct ttaaaataat acagttacca
    20041 ttttccgtga tatcaatcag ggaaaactca tcataactgc tacctgaaat atattcaaaa
    20101 acaccgctga ctaattcctc atacgcaatc acctccaaac cctttgccat ctccgaaatt
    20161 tgttgaatac gtaaaaagga ctttgataag ttgataataa catcacactc tgataatttc
    20221 tctttaataa tattaggcaa gtgatcagct gtaacaaatc cttgatatac atctagaatt
    20281 tccaaccaac tatcattaca atcagaaacc tctacgcatt caaaataagg cgatgccatc
    20341 cattcttctg tagtaattga agttgttata tatttttcaa aattcgattt ctcttcacct
    20401 gaacctgcaa ttaacgaacc actcacatta gactgaagag caaaataagc atctgaaata
    20461 gtagctaaaa actcatttcc accagtagag atagttgaag catatcctct aaaccccaga
    20521 gccgagtgaa ctttaccacc agtcgaatta agtaccatat caggaaaata aatactacta
    20581 gctctatcaa aacctttatt ccatattgaa ctcaaatatt tagcggaact ttccaaacta
    20641 ccataacgtg taccaaatac aaaaccaata tcgtcaattg attgattgtc taaataaaat
    20701 aagcttaaat tagaaacagc tccaatagca tattgactaa gcgtattcat acgtctacta
    20761 tataaatgtt tcttataccc tttaagatta aaaggatcta caaacgtttc tttccctccg
    20821 tttaaattga ccgaataaaa ttcgctaata taagaataat cattaatata aatctttttc
    20881 ctctcctgct gaacatcagc ggatttaact tcctttttat cgtcataaag gctacaaaca
    20941 atcgaacaat tataaccagc aaaagcacta ttgttcacta aaatattttg acttcctttt
    21001 ttaattgaac gcttttcatt aaatattaaa ttaacacctt gacaatcttg tctagtttcg
    21061 gtgtggttta aagttgcagg aagatatcct cgttccatta gcaataaagt actacttaat
    21121 tccaaagcag ctgcagctcc taaattatga ccaaaatagg acttacttga gctcacagca
    21181 atgctatcta aaaccgcctt cccaaaaatt gtttttaacc ccgaaagctc agcaccatca
    21241 tttgctaaag ttcccgtccc atgggtgttg atataagcaa tatcttcctt attgacctct
    21301 gaattatgta gtgccgactc aactgccttt tctacaccac caccttttgg atcaggggca
    21361 gttggatgat gagcatcatt gctaagccca taacctttta actctgcgta tatatgagca
    21421 cctcgtttta aggcatgttc cttattctcc aatactagaa aagcggctcc ttcgcccaaa
    21481 gataaaccag tattgacatc atacggtgca caaggttggt tagacaaaga ttgtaagcta
    21541 ctaaaacccg catacacagc tttcgacatt gcatcagctc caccagcaat gataagatca
    21601 ttacgcccaa gcttaatcaa gtcatacccc gtaccaatag ctaaaccact cgctgcacaa
    21661 gcagtattga aagtttgaac tgttccttgt atattaaatt ccttagctag ggtatctgca
    21721 ttttgactga aaatataacg ttcaagtcta tcttcgctta tgtcttctat gatattacaa
    21781 ttttctatag agcatatccc accattacac gttccataaa gaagggctgc cttagttaac
    21841 atgtcctcat ttaattttga atcaactata gcttctccta ttgccatttc agcaagaacc
    21901 aaagatctct ccttttctcg atcattggga acactgacct cacctccgac atgtgtttca
    21961 aattcatctg tatttataat cgtgagatct gtaattccag accgatccga taaaagataa
    22021 tctaatgtct cctttttatt cgcccctaaa caagaattga tgccaattcc tgttattact
    22081 acagtatttt tcatttttct cctccattcc attgtttagg tatcagtaat acaagccaaa
    22141 taatctttcc atcaattttt agttaaattt taaccgtatc ttactttcct atagtatcat
    22201 taaattctat cattactgaa aatttacaaa tatgcttttt tgaggggagg atttttccat
    22261 atttgcaaaa atattaattt aaatccttta tagcctataa taatatagag aaaggagacg
    22321 taatctatgt taaagtgtat aattatgcaa gcaattttat gtataccgtt tattataatc
    22381 gcctgcttat aagacaagca attgcaagaa tatatggctc attgtcaact atagtaggtg
    22441 actaataact aagcgtgcga gagaatcaga ttgtcaagtc ccatctaaaa tagacagtat
    22501 aaaaagagta ttatttagta aggtatgact tcctgaattc catagagtca taccttttaa
    22561 tttctcttgt ggtctgtggt agttatacca gttaatgtat tccctaattt gagagatgag
    22621 tgttcccttg tctttaggtg gcaatggtct taaggactca ctcttcaagt gagaaaagaa
    22681 attctcacag gctgcattat cgtaaccatt tcccttacca gaatgagaaa tgctcactcc
    22741 atattggtct agttttcgaa gatattgttg attggtgtat tgaaatcctt gatcagaagg
    22801 aagaatgcag accttagttg agtcccagaa atcattaaat acaagatcta tattatcaaa
    22861 aactaacttg ttatcattga aatcggatag cgtatagtct aaaatggaat tgtcataaca
    22921 atcttttatg acactcagta acatcctccc atagttgtag taaacgtagc tgacatccgt
    22981 tgttagtttc tggagagggc gttctgcttt aaagtttcgg gcaagcacgt tgtagtggac
    23041 gtgtcttgcc ttttcagtta tctctcgttg agtacaagaa tgatacctct tcttacgaat
    23101 aggtgagtga tgaccaagaa tacgcatata gcgcaaaata gtctttgggt tacggaagag
    23161 ttgatacggt cttctcagtt gataacagat gaagcgataa cctttctgag tatcatggaa
    23221 gaggtctgta accttttgag agaggtttga atcaaactgc ttatattcag gtttcccatt
    23281 gcttaaccag aggtagtatg atgaccttgg gaaaccaaaa taggaacata aagaggagac
    23341 agggtaacga ttctttaacc gatcaacaac ttgataaaga tggcctcttc tcactttctg
    23401 aggagagtcc ttaaggtttt taaaatagta ttctccatgt gtagataagc attctgctct
    23461 tctagtgaca tctcatctag atttctcgtt ttaggacgac cagtggactt agtgcctcgt
    23521 aaatcttgtg tgagtagggc tgggtttttg cggtatttcc ttgtccaagt tagtccctga
    23581 ttatctgatt ttaacccata ttttttgaca atggaaggca tccctccact cttcccacta
    23641 aggtaatctt ttacgacctg taatttgaat tctgatgaat acttagtgaa cttgcttcct
    23701 tttcatcttg gttctctctt ttgtgatgtt caaagtgatg agaatttttg ttttaaagtt
    23761 tttgaagttt cgaaagccaa aagcttggcg tttgaagacc ttgatgaact tgttggttgc
    23821 ctccagcttg gcattggaat atggagattc aaggcattaa tgatgtaagc tctgtatttc
    23881 agaaaggttt taaagactgt tgaaaggtga tgattgacta gactaaattc aaattgtctt
    23941 caatcagtcc aaaaaattga gttgttcgct tttcttgaaa atggaagagc agaagctgat
    24001 aaagatcgta ataatagcga agctcatcag agaaagccag cgccttgtcg acaatttgac
    24061 gagatgctaa ggtttgcctg aaagttcgtg aatagaaggc tttatcagag aatctggggc
    24121 tgtctttgtg gagaatccgc caatgatttt ccattgcttg atagggtaga aatttcttgc
    24181 caaaactctt catgatgggg attctggagg ttatcatggc gtggttcagg agcaggatga
    24241 tatggaagcg gtcaaggacg attctatcct ttgggagtga aacaatccag tggactgttt
    24301 cagcctgagc atgaaaataa aaaaacgaag ctgtttgatg atgagaatat agctgccaga
    24361 tatgtccatt gtcacaattt taacctgttc acgaaccttt ttagggtact tgtagaagag
    24421 gtttttgatg gttgttttca aggatagtga caatctttcg catctcaaag tcttgagcaa
    24481 tgaaggccaa tttgccctta tttcgagaaa attcatccca agataaagcc ttagataact
    24541 gtaattttga gaagttttct ttgaaagtga actgcgccag ctttcgctga acagcagaaa
    24601 ccgagatatg acatctcctg gcgatagcgg agttggtcag tttttcagtg tgcagttgcg
    24661 tgattttagc ccagacagcc ttgggaatct gacaattttt ctgaacgaga gatgtctcag
    24721 acacagagac tctccgacaa actttgcact gaaagcgccg ttttttgagt ttaagaacag
    24781 tggtcattcc ttgactatca aggataggaa tggatgatgc tttttgaaaa tcgtacttga
    24841 tcatgcgttc ctgacagtgt gagcagataa gagcttgata atccagctta gcttgtattt
    24901 caatatgggt ttgaaggtgt gattttgata tttttatctt tcaatccgat taaatctgtg
    24961 gtattctttt tagctttttt atttttaggc tcaagaatca acagtcactt ccctgactgt
    25021 tgatttattc catataagtc acatgggatt ttttcataca ttcaaaaaaa cctaccctac
    25081 aatgtgaatg aactgcaccc caaaagttag acagaaaaaa tctaactttt ggggtgtttt
    25141 tattatgaaa ttgacttatg aagataaagt tcaactatat gaactgagaa agctttaagc
    25201 ggctttcgaa tcaattttgg ggaatgtttc tggtctaaag tacatggtga gattaattga
    25261 ccgttatgga atagagatcg ttaaaaaggg gaagaatcgt tactattccc ctgaattaaa
    25321 acaagaaatg attgataaag ttctgctgga aggttgttca caaagaagtg tatctttgga
    25381 ttatgcttta cccgatcgtt cgctgttgaa aaattggtta gcacaataca agaaaacttg
    25441 ggaagaaatg acagaactag agcgacttca agaggagaac gaacgcttac gtaccgaggt
    25501 ggcctaccta aaaaaattaa aagagctaga agacagggac gaagccttag agagagaaaa
    25561 aggcagagac aattagagag atggtctcag gaggatttca attagattta cttcttgaaa
    25621 cggctagttt acctcgatca acttactact atcagttgaa ccaaattgag aaattgtgac
    25681 ttcgtagtaa atcataaaaa ggtccaacgt ttgatgaaaa tccttggttt gacggctcgt
    25741 attcgtcgta aacgtcagta ctcttcctac caaggagagg ttggcaggaa agcagataat
    25801 ctcattcaac gccagtttga agcatccaaa ccaatggaaa agtgttatac ggacgtgaca
    25861 gaatttgcca taccagcaag cagtcagaag ctctatttat cgccagtttt agatggtttc
    25921 aacagtgaaa ttattgctta taacctttct acgtcgccga acttagcaca attaaaaatg
    25981 atgttggaac aagccttcac agaggaacat tatgaaaata caattcttca tagtgaccag
    26041 ggctggcaat atcaacacca gtattatcat cgtttttaga ggataaggga attcaaccat
    26101 ccatgtcacg taaggggaat agtccagaca gcggtatgat ggagtccttc tttggcattt
    26161 tgaaatcgga aatgttttat ggttatgaaa ggacgtttaa gtcacttaac caattggaac
    26221 aagttattgt agactatatt gattactaca acaacaaacg cattaaggta aaactaaaag
    26281 gacttagtcc tgtacaatac agaaataaat cctttactta aattatttgt ctaacttttt
    26341 ggggtcagtt caatgtccaa ggaggattta cccactacgg gatattatag atccgaatac
    26401 actttgatat gctctagatc tcagaaaaag ctgagcaaca taaggctttc caagagcatt
    26461 agataatttt gaaatattta gagcgttacg ttatataatt aacacaaatg taattttatc
    26521 tctctgcctt tttgataaaa taaaatttat ggtgatgatt aaatttaaaa gcatgagatg
    26581 ccacaagaaa gatgtctcgc ttctgttcat aatcctgtga gttcataagc atattagata
    26641 gcctcatact gggcattagt aattttataa ttcttagttt taaccataat tttaaattta
    26701 tacttttaaa agggagtttt atttgctatg aagagagcgt ttgaattagg agagttatat
    26761 aaagatctta gaatagctag agggctaaaa ctaaaggatg tggtgcataa gaatttatca
    26821 atcgcacaac tttctagatt tgaaaatgga ctaagcatgt tgtcagctga taagttatta
    26881 ttggctattg aagggattca tatgaccttc tctgagtttg gtcacgcact aaaaaattat
    26941 gaggtgtcac atttttttaa attaacaaat cgtttatcta aattacagtc tttatctgat
    27001 atcgagggaa tacagaaaat acttaggaca tatgagtcgt ttgaaatttt tgatgtttac
    27061 aatcgtctaa ataaattaat tattgatgtt gctatcttta ccttagatca caagcattac
    27121 atttcagatg atgataaaga atttcttacc acatatcttt acagtattga agagtggact
    27181 gagtatgaac ttgttctctt tggtaataca atggttattc tatcagatga agatttactt
    27241 tttttaggaa agtcatttgt taaacgctat aagctttatc tgtctattct tagtaataaa
    27301 aaggccacag aaaagagttt actcaatctg attttaatct taattgagag aaaaagatat
    27361 tatcatgcca actattttat ctatcgttta gaagaaattt taacctatca ggatatgttt
    27421 gcgagagtaa ccttaacttt ttttaaatta ctagttagct atttacaaaa tgaagagaaa
    27481 attgataaaa cgaaattaat taattatatt aaaatagttc aagaattaga taacccaatt
    27541 cttgctaatt ttctaaaacg taatttagaa gagttaactc agaatcaatg actttcgtaa
    27601 taaagactgt gaaatagaat tgtatgtagc cttcaattac agtaaaagac caaattacac
    27661 taattgaata gtgaggtctt aaattaattt tccctaaaaa ggagcttcca tatgaataca
    27721 accactccat cccgaactat caaacatgcc tttgttactg gagcaacagg tcttttggga
    27781 aataaccttg tccgcgcttt actcaaaaag aatatccaag ttaccgcttt agttagatca
    27841 atggataaag cacaaaagca atttggcaat ctgcccattc gctttgttca aggagatatt
    27901 ctcaatccta aaagctacca atcctattta tctgattgtg acagcctctt tcacacagca
    27961 gctttctttc gtgacagcca taaaggtggc aagcactggc aagaactcta tgatactaat
    28021 atcacaggga caagaaatct tttgcaagct gcttatgatg ctggaattcg acaaatggta
    28081 cacacttcat ccattgctgt cctcaaaggc caacccaacc aacttattga tgagaccatg
    28141 tcgcgaagcc ctgacaccaa aatagagtac tatcgcagta aaattttaag tgatcaggtt
    28201 gtccgtgact ttatcagtaa acatcccgat atttttatta cctttgtcct accggggtct
    28261 atgtacggcc ctggcgatat gggaccaact tccacaggcc agatgatttt aaattatatg
    28321 caacaaaggc ttccaggtat tatcaaagcc agctacagcg tagttgatgc tagagatgtg
    28381 gctgatatcc atattcgggc tatgaagtac ggacgtaatg gcgaacgtta tctagctgct
    28441 ggtcaataca tgaccatgca ggaagtggta aagaccctag aagcagttac aagcatccct
    28501 gctcctaaaa gacagatctc tcgtcctttg cttcgggcct ttgccgcttg gaatgaaatt
    28561 tatcactcaa ttactggcaa acctgtctta gtcagtaaag atttagtcga gctctttgcc
    28621 gaggaatacc aacgcactca ctttgatcat accaagatgg agatagaatt gggagggcgt
    28681 ttccgtccag ttgaagagac aatgttagat accatcaatt ggtaccataa caatggatat
    28741 ttaaattaac acgaataaaa ccaccagtgt gaatgtcttg ggtgacttat agctaagtac
    28801 gagagaagac aaaagttgtc ttctcttttg ttatattcaa agcgagggaa gtgtgtttct
    28861 taaagttgtc aaagtttcta tacccaaaag cattttgctt aatgtccttg atgagtttgt
    28921 ttgtagcttc aagtttggca ttagaataag gcagttcaat ggcattagtg atatagtttt
    28981 tatagcgaat aaagatgttt aaagcagttt tgaaggtgtg attaagatgt ggaagcgcct
    29041 cgtttattaa gctaaataag cgttcggcat tcttgttttg taaatgaaaa aaggagtaac
    29101 tcatagaggt cataataatc ttttagttcc ggaaccagtt tgaagatctt attgagaaca
    29161 ctctctaggc gtcatggttt ctctaaatgt tctagagtag aaagtattaa gagagagttt
    29221 tctgctatct ttttgaatga tcttccagta gtatttcagt gcccgatatt ccagcgattt
    29281 cttatcaaat agcttcatga tttgaatacg ggtttgcttg agtgctctat tcatgtgctg
    29341 aacaatatga aagcggtcaa gaacgatttt ggtattcgga aataatagct taatgaagag
    29401 ggatatatct accagacata tcgacaatga taactttgtc cttatttcta gcatctttgg
    29461 aatacttgaa gaagagattt cggatggttg cttgttttct gttatcgagg agagtgatga
    29521 ttttctcgga gtagaaattt tgagcaataa aagctagcta gcctttttga taagaaaatt
    29581 cgtcccaaga cagtatttca ggtaaggttg tgtcatcgtc tttgaattgg aactggttta
    29641 gttttcaata gatggtagag gtaaagatag cgagtttaga agcgataggg taagagcttc
    29701 ttctgttgag taggagctga gatacctcag agatttggca atttttctta acgagagtgg
    29761 tttcagagac agttatcttt cgacaggatt tacactgaaa ccttctcttt ttcaagcgga
    29821 taagtctagg ggaaccacca atttcgatga aaggaatttt agaaggtttc tggaagtcat
    29881 acttaatctg ttttcccgtg cagtgtttcc attaggagga tgataatcta gtgtagctat
    29941 aattttggta tgtgtatcct gttgaattgc ctcattcaaa ctgatatgtt tgtctttaat
    30001 tccgatgagt aaagtggtat tattgatagg ttccataaaa tgctttctaa tgataggttg
    30061 gttgcttttc attataagtc ttatgggact tttttgatac tcaaaaagcc ctataattcc
    30121 agagcggttt tacccactat aaaaattata gagcctgttt cttgttcttg tatctatttc
    30181 tttattgtgg cttcgttaag tcccaccgtg ctcacataat agccctctgc ccaaaaatgg
    30241 cggttcccaa atttgtattt gagattggcg tgtttatcga acatcataaa agcatttttg
    30301 cccttcaaat tggacttggt ataataaagt ggacacgaag ttaagtgaaa acgaggaaaa
    30361 atatgatgcc aagaaagtat ttgataaagc attcaaaaat agctgcagtt aaactcattc
    30421 tagaggaaga cagcctgtaa agatggttag ttcaacttta gagggtcatc caaatcgttt
    30481 atatcgctga attcaagaat acgaaaaata cggagaaaga gcgttaggac aaggaagcgc
    30541 tcttcgtcat gtccaatttg agctgaaaaa acttgaaaaa gaaaataaga tattacaaga
    30601 ggagttagct ctcttaaaaa agttccaggt cttcttgaag ccaaaccgaa aataaaattc
    30661 caatttttaa aggaaaacag ttctagcctg aataataatc atgcttgtcg aacacttcaa
    30721 gtatcctgtt ctggcttcta cgcctatcta aagcgtaagc catcttcaag acagatagac
    30781 aacgaagcgt taaaggaaat cattaagact attttttatg aacataaaga acgctatcga
    30841 cgaggaataa gggtcaatcg caaacgtatt gctagactac ttcatgaact ttgtctctat
    30901 gctaaaggaa gcactataac cgtcagcgtt cctcattgag acgtccaaat ttgattaatc
    30961 agcgttttca aacaaaaggt aaaaatgaaa tctggctaga ggatttcact tatattccga
    31021 caaaagcagg gacactttat ttatctgtct ttatagatgt ctatatggga aatcgtatgc
    31081 aaggccagtt ggtaacagat gctcttaatc aagcttatca tagagaaagg cctaaggaag
    31141 gattaatagt ccatacagat caaggttctc aatagactgg agcacgattt caagatctgc
    31201 tgaggcagaa aaaatgtcag tctagtatga gtcgaaaagg taatccatat gataatgcac
    31261 tcatggaatc cttttacaag accttaaaaa gaggactcta taatatctgt agtgggtaaa
    31321 tccctttcgg atattatagg gcttttttag tgtatgaaaa aagtcccata tgatttataa
    31381 tgaaaagcga tcaaacttac attagaaaga ctcatatgga acatcttaag aataccacag
    31441 atttaatcgg attgaaagac aaaaatatca aaatcctgtt tgtctgacaa cttcaaaccc
    31501 acatcgaaat aaaagctaag ctggactatc aagctcctgc ctgcccacat tgtcaggcaa
    31561 atatgatttt cagaaagcat catccattcc tatccttgac agtcaaggaa tgcctactgt
    31621 ccttaagctc aagaaacgac gttttcagtg caaggcttgt cgtagagtct ctgtgtccga
    31681 gacacctctc gttcagaaaa attgtcagat ttccaaggct gtctgggcta aaatcacgca
    31741 attacacacc gaaaagttga ccaactcggc tatcgctaaa agattgcaca tttctgtttc
    31801 tgtcgttcaa tgacaattag aacaattcac ctttaaggaa aattacgata attgcatcaa
    31861 atattatcct gggatgaatt ctcacgaaat aagggcaaat tggccttcat tgcacaagat
    31921 tttgagacga gaaagattgt cactgtcctt gagaacaaca agcaaacaac cattaaaaac
    31981 tacttctaca actaccctag aatggttcga gaacgggtta aagtcgtgac tgtggacatg
    32041 tctgctagct acattcccat catcaaacaa ttgtttccaa atgctcagat tgttttggac
    32101 cggtttcaca ttatccaaca tctgagtcgc gctatgatga gtacccgggt agccatcatg
    32161 aagcgttttg acatcaagtc tctaccctat cgagctatga aaaatcattg gcatattctc
    32221 cacaaggata gtcggaaact ttctgataaa gccttctatt cacgaacttt caggcaaacc
    32281 ttaacacccc gtgagattgt cgacaagacg ctggctttct ctgatgaact tcgctattat
    32341 gacaatcttt atcagctcct gcttttccat tttcaagaaa agcgagcaac tcaatttttt
    32401 gaactgattg aagaccattt gaacctagtc aatcatcgct ttttaacagt cttcaaaacc
    32461 tttctgaaat acaaagctta catcatcaat gcccttgaat gtccttattc caatgccaag
    32521 ttggaagcta ccaacaagct catcaaagat atcaagcgcc aagcttttgg ctttcgaaac
    32581 ttcaaaaact ttaaaactaa aattttcatc gctttgaaca tcacaaaaga gagaaccaat
    32641 ctgattctct ctcgtgctta gttataagtc acccactaca gttgacaatg agccaaaaag
    32701 agagcttgtc aacgatgcac attttgcatc cattgaacaa gcccaacttg aaatctttaa
    32761 atagattgaa acctattaca atccgaaacg tatccactcg accttgggtt atcaataacc
    32821 aatagagttt gaaaaatata atcactaatt aacttcctgt ctactttttc ttgacaagtc
    32881 cattcactag aagctataaa gggagttttc ctatgtccaa aagaagttca aagcctgtag
    32941 ctgaaaaact tgagattgtt ttgttatact tagaacaagg aattctggag tagagcatca
    33001 aaccatcaaa gattgggtta gaaaatacaa aggctcaggc atagaaggcc tcaaacatag
    33061 taagattagt agtgagaaaa tctccgacgg gagagagtac tcactacctt ttctttatgt
    33121 taaagtagag gtgtcttgtt aagtcgcaag actttatggt gctagacgtc gtgtctcaaa
    33181 ctggcaagac acctatttta gatggaatgt tatcaaagta tgtgggatgc cagacgttga
    33241 atattgaaaa cgatatcact aaaacaagga atctattcaa gacaaagagg taatatcatg
    33301 cgagtcgtat ttgggattga tgtgagtaaa gcaagttcag aagttgctat tctaatcata
    33361 tgaaacctga tggggttgtt tattccttta agaactactc tcgtcaaact gacaagtata
    33421 gatttaaaca tgattttaaa atctacgagg cagacaaaac gtaagacaca ccatagttgg
    33481 aacgactagt caaagcagaa ggtggtcgtc agaaacaaat tcattataat ccaacttgga
    33541 attcctttaa ggaactctca aggaagaact gcatagcgaa gaaggctctt gtctctacgc
    33601 caagcgcaag ataatagctg ttgaacctgt ttttagccga ttgaagagtg tattggtgtg
    33661 cgcagagttc atgtcagagg caatcaagcc gtccaaatgg aactcggatt cctcttcatg
    33721 agtatgaatc taacaaaatt gaccacgaat ttagttacta acatgactaa aaatcaaaaa
    33781 ccacactgta ttgacgtcat cttgtttggg ttttcaaaac tgaagtcccc gtgtggcttt
    33841 atttgaagtt agtttttgcc cagactcttt caaaagccaa aaaagagcga gactaaaatc
    33901 aagaatcctc tcgtcgaaat tgattttaat cttgattttt gaccactgac ttagggaagc
    33961 ctaaatctat tgctgtaaga tcgccaacgt ttggtagggt tttaaggtga ttgctgcaga
    34021 aagttcgaca tcatcataat tgctgattag aatttctcct gtttgataaa gggaaggcaa
    34081 gtctagctca actgtttcag caaagaaatt attgagaacc agcagctttt ggccttcgta
    34141 ctctcgttca aaggcataga ttttatcact gtctgtcaaa gctgcttgat aactgccttg
    34201 agcaattagc ggcatttctt ttcgcaaacg aatcaatttt tgataaaaag gaaagatctt
    34261 accttgtttt tcattagcca cattgatttg tgggtagctc tttccaacct taagccacgg
    34321 cctgccagtt gaaaaacctg cattctcgct agcgtcccat tgcatagggg tacgtgcatt
    34381 atcacgcgat ttggctcgaa taatgtgaaa ggcttcctca gaagatttgc ctttatctat
    34441 taattcttga taggcattca ggctttccac atcaacataa tcagccatag aaccatagtc
    34501 tggatcaatc atgccaattt cttcccccat ataaatatag ggcgtaccac gagataaatg
    34561 aatcgaggct gcaagcatgg tcgctccttc attgcgaaac tgcttaatat caacaaagcg
    34621 attaagcgct cgtggctgat cgtgattatt ccaaaagagt gcagaccagc cgttaccttg
    34681 actcatccct tcaccccaag tatgaaagag atgtttcagt tcttcaaaat caaacgtttt
    34741 gcgtgtccat ttttgaccat tttcataatc cactttaaga tggtgaaaat tgaagatcat
    34801 atccaattca tggttgtcgg gattgctgta ttgtatgcag ttaggaatgt ctgtaaaact
    34861 catctcgcca acagttatac cattttcatc ctgaccaaag ctggctttat tgagcatttt
    34921 taaataatca tgattaatgg gacggtctgt atattcaggt ttcccatcaa aatgaggatt
    34981 atcctttagg acctcgtctt tcccaatcac attgataaca tcaaagcgaa agcccttgac
    35041 tcccctgttg cgccagaaat tgaccacctt aaacagttcc tcacgaacgt gaggattgcg
    35101 ccaatttaaa tcagcctgcg tgacatcata caggtgtaga taatatttcc ctgtatcccc
    35161 aaaaggagcc catgcattac cgccgaattt agaaacccag tcagtaggcc tgtctcttaa
    35221 aataaagaaa tcctgataat acttatctcc agccaaggcc ttttggaacc attcgtgttc
    35281 tatcgaacag tgattgagta ccatgtccag catgatctca atgccatgct cttttccttt
    35341 acgcgataat tcttcaaaat cggccatgct cccaaataaa ggattcacag cagtataatc
    35401 agaaacatcg tagccattgt cacgctgagg actgggatag aatggattga gccagatgac
    35461 atcaattccc aattcttcta aataaggtaa tttttcaata attccctgaa gatccccgac
    35521 cccatttcca cttgtgtctt tatacgattt gggataaatt tgatagacaa ctttcctttt
    35581 gtctaatgtc attttattct ccttacaata attgatccta tattttgctt gctgttaaga
    35641 ggacctcacc gcgttcaatt tcacgaggaa ggcttccaac gacatcaggc tggtagtcat
    35701 tttgattggt gacaataaca ggtgtctctg tagtataacc tgcctgatgg atagcatcaa
    35761 tatcaaaacg aatcaatttg tctccgacct tgatcgtatc tccttgtttg acatatgttt
    35821 caaaaccttt tccttccaga ttgaccgtgt ccataccaat atggatcaat aattcaagtc
    35881 cttgatctgt tacaagacca atagcatgtt ttgttggaaa gaggacagaa accacaccat
    35941 taacaggaga cgttaagaga ccttcacttg gatcaatcaa aacgccttgt cccatgacac
    36001 cttgggcaaa aacaggatca actgcttcag acaagggttt gacttgaccc tttaaaggac
    36061 ttttaatctc aaacgttgtt cctacagcag gttcattagt cttttctgat gctgatattt
    36121 cagcagtttc tgttttttct tgatgagctt catcttcaga tttagtgaga aagttaatcc
    36181 tacggaagaa aactgttaaa accatgggaa ctgcgatagc cactaacata atgatgaaaa
    36241 atggaagcat gtatttaact ttgatagaca aaattcctgg aagaccacca ataccaatag
    36301 cattagctgt tacgttaaat gtgactgaaa ggaagcctgc aatagaagag ccaatcattc
    36361 cagctacaag aggataaaca tatttgatat tcaccccaaa aagtgctggt tctgtcacac
    36421 caagataagc tgagatagtg gctggaagtg aaacttgtgc ttcacgttct tcatgacggt
    36481 tcataagata ataagcaaat actgctgatc cttgagcaat attagaaaga gcaatcattg
    36541 gccatagtcc tgtacctcct gtatctgcta ctaattgcgt atcaatagca ttagtcatat
    36601 gatgtagacc agtgataaca aatggcgcat agagagctcc aaagatagct ccaaaaagcc
    36661 acttaacagg accggttaga cctgcatata caattgttga aatccattgt ccaatagtcc
    36721 agccaattgg ccccagaaca gtatgggcta aaatcaatgc tgggataaga gataaaaagg
    36781 gaacaaaaat catggaaacc acttctggaa ttttcttgcg ccaaaagatc tcaagatacg
    36841 aaagagaaag tccagctagt aaagctggga taacttgccc ttgataacca atacgtctca
    36901 ccgtaaagaa accaaaatcc caaacccatt ttttagcgat ttcagctgcg ggcgtactgg
    36961 ctacattgta ggcattcagc agctgcggtg aaaccaaaca aattccaagt acaataccta
    37021 aaatttgact cgttcccatc ttacggctga cagaccaaac aatacctaca ggtaaaaatt
    37081 ggaagatggc ttcgcccggc agccatagaa atgaactgat accactccaa aattgtgaat
    37141 gctgtgcgat tgtttgtcca tctagaaatc cccattgaac ctgatcaatg acattacgaa
    37201 atccaagaat cagcccccca acaatgatag ctgggataat aggggtgaaa atttctgcta
    37261 acagagtcat cacgcgctga ataggattct gatggctttt agcagccgac ttagcggttt
    37321 ccttagagac cccttcaata cctgaaacag ctgtaaaatc attataaaac aaaggaacat
    37381 cattcccaat aataatttgg aattgccccg cattggtaaa agttcccttt acagccggaa
    37441 tagcttcaat ggtcttaaca tcggctttac tttcatcatt taaaacaaag cgcatacgtg
    37501 ttgcacaatg tgtaacagca gaaacatttt ctttgccgcc aatagcatct agtaatacct
    37561 tggcatcttt ttcaaatttt cccataaatt tttcctaggt taacctagtc ctcctttaat
    37621 atgataacag tatgtttact ttttcattgt aaacgattac aaatttgttg gcaagttgtc
    37681 cataggaaaa aagcgcaatt tttgttaaaa taaggtcagt tgtatgcatt tttttagaca
    37741 aattagattg aattgcttat gaaaaaatat aaaattattt ttaaaaaact agaagaagat
    37801 attctcaaag gacactatca aatgggtgac tatcttcccc ctgaaatgga acttagccag
    37861 atctatgcca gcagccgaga tactgttaga aaggctttac agctcttgac taaggcaggt
    37921 tttattaaaa cagtacaggg aagaggatcc caaattatca agcgtgagcg cattaacttt
    37981 cctgtttctc aactaaccag ctatcaagaa ttggttaaac aattgcagat gaatgtcaag
    38041 acaaatgtta ttgctattga taaactgatt attgatgaga aactcaccaa actaaccggt
    38101 tttgaaaata aaggtcttgt ctggcgcatc acaagacagc gcgtcataga cggcgttgct
    38161 tccattttag atacggatta tttggataaa gcattgattc ctcatatgac cagagaaatc
    38221 gctgaacatt ctatctatga ttatcttgaa aatcaactta agctggacat tgcctatgct
    38281 caaaagatta ttaccataga tcaagtatcg caaaaagata aaattttgct tgatttggat
    38341 tctgaaaatc atgtcgtttc ggttaaatct aaagtttatc tcagtaatca gcagcaattt
    38401 caattcactg aaagccggca caaactggaa aagttccgtt ttgttgactt tgccagacgg
    38461 catcgtgatt aagacaacaa ggaaagcaca aaagaaaaag aggctatcat ctggataaat
    38521 aattatcaaa aagcacctat tttacaatgc taacaagtgc acagcactgc ttgtattgca
    38581 tcttttttct gtctatgaat ggctatcagt cggacacctc atttaaagtg gctagaaaaa
    38641 acgattaaga ttgctgcttt tcaagatgat tttaaagagt tgaaagttaa tattgtgcgt
    38701 tttctaaaag agaataatcg agtgattaat ttgtgatatg caaaaacctc agatacaatt
    38761 atctgaggtt tcttgtcaca taataaaact tacaatgaaa ctatcgcact attacaatca
    38821 atcttttttt ctacccttta tcaagcttaa taatcctgca gcgccgatta gaagcgcacc
    38881 agcacctatc actttgagga gattggagcg cgtttcattg ttatctcctg tttgcggtaa
    38941 ctctgcttgg gagattgaca atgatcgttt ggaaagagtt ggcagctgca agtcattttc
    39001 ttcaccggtt aaggctgaaa caatctcatt tttattttca tctactgcct gcttattagc
    39061 tactgggaga gggctgactg cttctggagt ttgcggaatt gctggttcaa gtgtcctagc
    39121 aggatgttgg ggctgttctg gaactttagg cgtttctggt ttaatggttt cattaatata
    39181 aatcatatcc caaagcgtca gtcttggcac ttgaatataa agaacaggat cgccattctc
    39241 attcgttttt acctgggtcg ctagagaaat catactagat tgcagccaat catctggtga
    39301 cgtcagatag acttgtttag ctattcgatc agcctctgcc atagacacac cagtcaaagg
    39361 ataagtaacc aataaattgg tttgctcatc aggtgtttta ttattttcat aaccatcttc
    39421 atttttccag tcggatgtaa ttcccataag gttgagcaat tgaatcgttc tgaaatcgtt
    39481 tccctttttg gcataagtcc aaacctgatc gccattgatc cccaaagcat cttgcgatag
    39541 ctgccgaccg ttagcagtga aagtctgagg ttcagcagaa tcattttcaa ctttatcacg
    39601 caaaagattt tcataagccg taataaattg ttggtaatga tagtttttac gattgagctc
    39661 tttcgagacc ttgaggcttt gtgttggata ataagctgtt tctaagacac cgacaccacc
    39721 cccatcatta ggattagcca aagcagctag agacatgtga tatcctcctg ctgccgcaat
    39781 ggccgcagtt gtcagcagaa ccgcatctgt ttggtaagtt gctgaagcta aaacgtcacg
    39841 cgctgcacca ttgagaggaa ccctattatc atcaaattta ggctcttcca tataagctcc
    39901 gacaatcaaa gatttccctg tcgcttggcg aacttgatca acacgagctt tcaagtcacc
    39961 ataactttct tggggacggt tccccaaagc tgaagttcca aaaggccata attcattgta
    40021 aatcacatct tgtttgctgt tggcgagttt gctgatattt tcaccattaa catcattgag
    40081 tgttaaataa tactgaggca gtttttcctt cattttattg agaaattcag catagacatc
    40141 agataacata aaggaatgag caatatctcg actgtccttt tgattatggg aaagaacacg
    40201 attatctcca attgtatctc cctgccagcc atcaaaaccg ccagttttca tagcttgagc
    40261 catggcatta gaaatataat tttgccaact tttactcaaa ggattgtaat aatattgcag
    40321 cggcttatca tcaatagagt aagtcatgac ctgaccattt tgaccataac caccagtctc
    40381 ataattatag atgtactcag tatctggtaa aacagccgtt tcattagcat tctgtgctaa
    40441 aatcatatta tagagcatgg caacagcgcc agtttgatgg acacgattga ccaaggcttt
    40501 aacagcatct gtttcaacct gcgaatggct ccaccaattc caagactgat caaacttagg
    40561 aacattaggg aaaggatttg tagcagactt ataaacatca tagaagaaat aggaattaat
    40621 gttcatattt ttcatctgct ctaattcgcg ataataatct ggtaagttct tagtcaagac
    40681 actgttattg tctttttgag aacctccaat agcagcataa cgcggaaagg tacgccagtc
    40741 atcctcaacc gcaatagccc gattgccctg ctctaaaata ttattttggc tatctgatat
    40801 gttaaccttc aaaagataac cgcgattatt agctaaggag tttgcaggaa taacgaattc
    40861 acctttttga gttgtataac tttcattagg cagaagatac ttcgtatact gaagtgtctt
    40921 taatttattt tcaagagaat aaacctcagc agtagctgta atattttggg ctaaagatgt
    40981 tgtattgttt aaagtaagat tcaaatgaac agcctctccc gcttgataga ctgctttatc
    41041 tgttgtcaga tttatcatgt tgccattctt ttggttctgt gcagtttcta gcacaaccct
    41101 ttctttattg gcggcagata ccatttgcat tggctcctga tgagaattgt tagaaagttt
    41161 cttcgcttga ggttgtgtgt tagtatttgc agagaccgat tgtccctgtt cattagaatc
    41221 tattgacgcc ggttctgtct gtactgcagc cgcagcatcc tccttctctt gcaccttaag
    41281 gtctgtctct tgaaaagagt taatggtcga atccaccgtt tcagctgacc taatagctgg
    41341 ttcagccgtt tgcctatttg actgttccat accctcagca ggcgcctttt gagttacatc
    41401 gctcatacct gtcatgtctg ttgaactatc atcagccaat actgccatac catttgtaaa
    41461 aagcagtatg gttacaacag aggataagaa tatcttaatc attctttgct cattcttttt
    41521 cattttttaa ctccaagtat tcattttgtc atataatatt aatatcaaca atataaattt
    41581 gtattttatc aaaaatatta caaaatttca atgagagttt catgaaaatt tccaaacttt
    41641 ttcatataag attgatgata agcaagattg aatgcatcaa atggtcactg taagaagact
    41701 tttaaaggcc aatgaaagtg agataaactt ctatgattgc tgtgcaatta tccacaaaat
    41761 agtgtaatct atcagattac gaataagaaa tcctgagatt gtcatataaa atagccgtaa
    41821 tagtctgacg cagtgactat ttctgaacaa gtctactctt tattttttgt atccaataga
    41881 atcgtcacag ggccatcatt agtaagagat acctgcatat cagagccaaa tattcctgtt
    41941 tgaacaggaa caaactgagc tagctcttgg ttaaattgat catacaaata actggctaaa
    42001 tccgcttgcg ctgctcctgt gaaggccgga cggttgccct ttttcgtatt agcaaaaaga
    42061 gtaaattgag acacagaaag aacctcccct ttta
//
