LOCUS       NZ_CP023477            24234 bp    DNA     circular CON 18-JUL-2024
DEFINITION  Streptococcus mutans strain LAR01 chromosome, complete genome.
ACCESSION   NZ_CP023477
VERSION     NZ_CP023477.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2088369)
  AUTHORS   Abranches,J., Lemos,J., Kajfasz,J. and Aviles-Reyes,A.
  TITLE     Whole genome sequence and phenotypic characterization of a Cbm+
            serotype e strain of Streptococcus mutans
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2088369)
  AUTHORS   Abranches,J., Lemos,J., Kajfasz,J. and Aviles-Reyes,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-SEP-2017) Oral Biology, University of Florida, 1395
            Center Drive POBOX 100424, Gainesville, FL 32610, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: celera v. 9/01/15
            Genome Coverage                   :: missing
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002995555.1-RS_2024_07_18
            Annotation Date                   :: 07/18/2024 01:10:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,086
            CDSs (total)                      :: 2,002
            Genes (coding)                    :: 1,930
            CDSs (with protein)               :: 1,930
            Genes (RNA)                       :: 84
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 41 of 72
            Pseudo Genes (incomplete)         :: 35 of 72
            Pseudo Genes (internal stop)      :: 29 of 72
            Pseudo Genes (multiple problems)  :: 25 of 72
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:47:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1400311
            Orig. end                         :: 1424545
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023477.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Jacqueline Abranches.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24234
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="5"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24234
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24234
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14234](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14234)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    231..245
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.75"
                     /tool="antismash"
     gene            complement(264..923)
                     /locus_tag="CO204_RS07145"
                     /old_locus_tag="CO204_07115"
     CDS             complement(264..923)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019323543.1"
                     /locus_tag="CO204_RS07145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07115"
                     /product="response regulator transcription factor"
                     /protein_id="WP_019313147.1"
                     /transl_table=11
                     /translation="MTRILVIDDEEDILALIKNTLQLQNYLVETFVSANQVDRSKLADY
                     DLILLDIMMPDVDGLSFCRDIRNLVDCPILFLTAKSQEADVVTGLSYGADDYICKPFGV
                     QELLARVDAHLRRERREHHASLVLEPIRFDLSAKRVTAKGKKLDLTKSEYEICELLAKR
                     RGQVFSKDQLYDYLYAYEERGTPAAIAEHIKNIRAKFRTIGLEPIETVWGIGYKWK"
     gene            complement(957..1313)
                     /locus_tag="CO204_RS07150"
                     /old_locus_tag="CO204_07120"
     CDS             complement(957..1313)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268814.1"
                     /locus_tag="CO204_RS07150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07120"
                     /product="hypothetical protein"
                     /protein_id="WP_063330927.1"
                     /transl_table=11
                     /translation="MRIVSSLVSLLLTIFWIFAIAFIPIGDQNSFNKPEMWFFVFFAII
                     IYSIVIISDYYLKNFNLLKVYQILVLFISILCALCGLSLTALGLKVFTLAIGIVSLVNT
                     IIYFFFANKKDNVE"
     gene            complement(1327..3249)
                     /locus_tag="CO204_RS07155"
                     /old_locus_tag="CO204_07125"
     CDS             complement(1327..3249)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268813.1"
                     /locus_tag="CO204_RS07155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07125"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_002268813.1"
                     /transl_table=11
                     /translation="MFLPKISFHNLIVNKSLTLPYFAIMTIFSGFNYVLINFLTNPSFY
                     NIPTARILIDILIFGFILISLLMLLYGRYANRFISDERNSNMGIFLMLGMGKKQLLKII
                     YLEKLYLFTGTFFGGLIFGFVYSKIFFLFIRNLIVIGDVREQYSLTAISWLLILTFFIY
                     FIIYLSEYRLLKRQSITVIFNSKAKRDNPRKTSVFVGLFGLFALLMGYHFALTSPNVTT
                     SFSRFIYAACLVTLGIFCTFSSGVIMLLTVIKKRRAIYYNQRRFVVIASLFHRIRSNAL
                     SLATICIFSTATLVSLSVLASLYLAKDNMVRLSSPRDVTVLSTTDIEPNLMDIATKNHV
                     TLTNRQNLKVSQSVYGNIKGSHLSVDPNGGMANDYQITVISLDSFNASNNTHYRLKNHE
                     ILTYVSNGAAAPSSYTTNGVKLTNVKQIKRINFIFSPLRSMQPNFFIITDNREIIQTIL
                     KEELTWGTMAGYHVKGKKMNQKDFYDELETTNFRQFSANVVSIRQVKSMFNALFGGLLF
                     VGIIFGTIFAILTAITIYYQQLSEGIRDRDDYKAMIKLGMTNKTIQDSIKVQINFVFIL
                     PIAFALLNLIFALPILYKIMTTFGFNDAGLFLRAVGTCLIVYLFFYWFICHCTSKLYYR
                     LISKK"
     gene            complement(3265..4005)
                     /locus_tag="CO204_RS07160"
                     /old_locus_tag="CO204_07130"
     CDS             complement(3265..4005)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002275158.1"
                     /locus_tag="CO204_RS07160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07130"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_106006792.1"
                     /transl_table=11
                     /translation="MTYIGVSHLKKVYKTQEGLTNEALKDITFSVQEGEFIAIMGESGS
                     GKSTLLNILACMDYPSSGHIIFNNYQLEKVKDEEAAVFRSRHIGFIFQNFNLLNIFNNK
                     DNLLIPVIISGSKVNSYEKRLRDLAAVVGIESLLSKYPYELSGGQQQRLAIARALIMNP
                     DLILADEPTGQLDSKTSQRILNLLSNINAKRKTILMVTHSPKAASYANRVLFIKDGVIF
                     NQLVRGCKSKEGFLDQIIMAQASL"
     gene            complement(4029..4775)
                     /locus_tag="CO204_RS07165"
                     /old_locus_tag="CO204_07135"
     CDS             complement(4029..4775)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002261884.1"
                     /locus_tag="CO204_RS07165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07135"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_106006793.1"
                     /transl_table=11
                     /translation="MVKLIWAEFLKYNRTFLPWIHVILPVGIAVLTAVFGLVTPAYSWG
                     SITSGYLQVLGIAFPLVIAITCSKAVELEAEAGHFQTVLANSQRKVLYFIKLVNLMLME
                     IIAVCLALSVFGLLYRSKIDVPYLAFYGYAGLLLIVSTVILYLLHLVIAFLFDSGATIG
                     LGIFEVLVSALLLTGLGDNIWQFVPAAWPARLMGTLFEMLQCPDQNPIFAQQILLWLEV
                     AVPLTLMALILSIIWFDRWQGRSSDE"
     gene            complement(4775..5524)
                     /locus_tag="CO204_RS07170"
                     /old_locus_tag="CO204_07140"
     CDS             complement(4775..5524)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002267127.1"
                     /locus_tag="CO204_RS07170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07140"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_106006794.1"
                     /transl_table=11
                     /translation="MLGMFQAERLKLKRTMAKKLLFLGPLLVVIHGFMLPQYLITDAYN
                     WWYIMIFPGLLTLFAALINTYEEKKLHYRAIFPLPISLRKFWINKVLTLAYYLTLSSFL
                     HCFILVLLKYFIFPHYGETYLISQMLLASMVLLLSVLWQLPFCLWLAKKLGLVITVLVN
                     FTANVILGIAFSTTAYWLLCPYAWSIRLMIPLMKIYPNGLKAGSEAAAPLLATSNWSIM
                     LSLTLALILFAGLTWLTALWFEKQEVK"
     gene            complement(5526..6227)
                     /locus_tag="CO204_RS07175"
                     /old_locus_tag="CO204_07145"
     CDS             complement(5526..6227)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019315151.1"
                     /locus_tag="CO204_RS07175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07145"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_002267872.1"
                     /transl_table=11
                     /translation="MDYMLETKNLTKQFGKQTAVNQLNLKVERRSIYGLLGPNGSGKST
                     TLKMITGMLRKTSGHILIDGHDWSRKDLENIGALIESPPLYENLTARENLKVRTLMLGL
                     PDSRIDEVLKIVDLTNTGKKRAGQFSMGMKQRLGIAIALLNSPQLLILDEPTNGLDPIG
                     IQELRNLIRSFPTQGITVIISSHILSEIQMTADHIGIIANGVLGYQDRIHQDEDLEKLF
                     TDVVMRYRGGE"
     gene            complement(6438..8063)
                     /locus_tag="CO204_RS07180"
                     /old_locus_tag="CO204_07150"
     CDS             complement(6438..8063)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268808.1"
                     /locus_tag="CO204_RS07180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07150"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_106006795.1"
                     /transl_table=11
                     /translation="MKWLEVLQISKKEKILYLIGCIFSIMTGLITLRITYLLKNLVDGK
                     SSFNNLFLFLVLGLVLFIIDAGSQYLISLIGNQVVFNSRNNIWKKISDWTDSKDDSSEM
                     AGHLINDSELIENFIISTIPQSINSVIVGSGSLVMLFVINSKMSLEVIGICFLLLFIMQ
                     PFSRILSKISKRIQEDKAELINIASQLRGQVKTIKSYNAQDYAFQKFDEQNRQLFQDIL
                     NRIKIFSIYSPFLNILILFMIIIVVWLGNTEVRSGNLTVGSATIFVVYMTQLINPIMQL
                     SQLVAHMGMLNGGVERLLEYNQAIPEKNGIKKIDEIINIAFDNVSFAYDNQENIIENVN
                     LTFQKGTYISIVGESGVGKSTLLDLLEHNYVPSKGRILINGIDLEELNIKTLRNKISYV
                     SQEPTILSGTIRELLDFNQQQHTETSLWNVLDTVELSELIRNLPRKLDSKVDEYGGNLS
                     GGQMQRISLARGLLKAGDVLLLDESFANIDEETCLKIKLKIAAYAESHKQIVIEVIHNL
                     NRITPSSIVYRLADKKLEILRSGF"
     gene            complement(8064..9407)
                     /locus_tag="CO204_RS07185"
                     /old_locus_tag="CO204_07155"
     CDS             complement(8064..9407)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002270855.1"
                     /locus_tag="CO204_RS07185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07155"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_063330929.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 4.2e-43, bitscore:
                     144.6, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKGLLVIIFLTFFFFYPKAKAAEYTIISNNSEQTVNDLNNLGV
                     TVNSHIAEIGYIEAQGDVNIDQIKKLSNIKSIQNMADTSQNITTRVPSTYINQTIQLPQ
                     LFSYQWDMQKITNNGVSYSLNKENRKNVTVALVDSGIDVDHNAFTGMIDSRSKNFVPAG
                     GYDNSESSETGSINDIDDKKGHGTAVAGQIAANGQIFGVSPGTNLLVYRVFGKSKSKEC
                     WILKAIIDATNNGANVINLSLGQYIKIPNGDIWESAEALGYKFAIDYATRHNVIVVAAT
                     GNDGLSDDNGEVKTYYNSQHSGQDMSQNDTVEDYPSVLPNAIAVGSSDNNNQRSSFSNY
                     YNQYQDNFILAPGGGTTLLDQYGQEEWYNQKLFMKEQVLSTSNNGNYDYADGTSISTGK
                     VSGELAEIISNYHLQGDSSKARSILLNQVNYTSDGYKEISTYKALRGY"
     gene            complement(9412..9978)
                     /locus_tag="CO204_RS07190"
                     /old_locus_tag="CO204_07160"
     CDS             complement(9412..9978)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002289981.1"
                     /locus_tag="CO204_RS07190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07160"
                     /product="flavoprotein"
                     /protein_id="WP_063330930.1"
                     /sec_met_domain="Flavoprotein (E-value: 4.1e-33, bitscore:
                     110.9, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEQNTEKKILLCLTGSGALLGITEYITFLTVRFKHVRVIVSDNA
                     AKMLPVAAITQLCEKVYTDEVSFTDKQKNHIALTRWADITVVLPATANIIGKVANGIAD
                     NFMTTTLLSSSKPVLIYPCMNNIMWENPVVQKNVEVLSGTQYKVIVGQESESFELASGK
                     MKKNIAIPSLDELQRVVLENLQEER"
     gene            complement(10001..11275)
                     /locus_tag="CO204_RS07195"
                     /old_locus_tag="CO204_07165"
     CDS             complement(10001..11275)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002304548.1"
                     /locus_tag="CO204_RS07195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07165"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_002268805.1"
                     /sec_met_domain="LANC_like (E-value: 9.6e-53, bitscore:
                     176.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQSKRVEKIKNILTEQTYLFDYQEVLKKISQVKQTDFWNLLSLS
                     SGITSLLIFYQEYENLEGVNLKPQKQSLIGLISYYINQIADKSSLFDGLAGVGFAINYV
                     SNNGKYYQKLLNQIDSKICQNVKRNLADCNSEEYTNPMNYDVISGNAGVARYLMERESS
                     EDWRIVEMILEVFYKALEQGWRVQPKYQFLESEKQYYLKGNINFGLAHGLLGPTTIMSL
                     YQQRYPQNTRNAEKLQETYHFIKRYAQLRDEGLRWPIRYDLLRKEGSFILRNGWCYGDN
                     GIYSTLFLMGKVLSNQKICETAQKVIPSIIKDDYEKMESPTFCHGFAGKANFFLLQYQR
                     TKESIFLVKAEEEIDKILIVYNSENMFGFKDIEDNIDNTEERLTYWDNFGLLSGTVGVL
                     LVLMEYCNIVNAGKVSEWNKIFLLT"
     gene            complement(11262..14234)
                     /locus_tag="CO204_RS07200"
                     /old_locus_tag="CO204_07170"
     CDS             complement(11262..14234)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002270852.1"
                     /locus_tag="CO204_RS07200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07170"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_002268804.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.4e-116,
                     bitscore: 385.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.9e-10,
                     bitscore: 37.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.8e-17, bitscore:
                     58.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDFQFQDYFMYRKPLGNFSNFFSITDTMDPIELLHSDPIFAEGV
                     YLASSSLRAAINKLKNHTASTKDKKNARETIFQYYARYNTRSTPFGLFSSIGVGAFSAY
                     LKKEKSRYEKSINIDLFWAYKVADKLESMPEILNTLKVVANNALQKSDNFWLLDTRSHF
                     GLMNSRSDIHEDITVKSNQLIDYVINCAEQPICYPTLVDNIAEKFSQSSDGVKKYLQKL
                     IKEEFLITELKFSLIEDNPLDWFINILERTQNNLELLEKLTEIKAMIQDYTDCDIGEGN
                     NLILALENKMSQIAETNAYLRVDLYDHAELELSHHIKDSLQNILKVLSSFSPGINSRKE
                     IRNYHEKFISRYGYEQLVPLQLLLNSTSGLGFPKGYSQTKDFKQNNGDSRNQKITEFLQ
                     RKFEKSLRDGKEIILNDDDLKDLDFDKEQQISGELYCFYDFKNRKLEVSGLGVSPMIGD
                     TFGRFHAKLPNTIITENVNKTKEIFAKAYPNTIITQLNEVPYFGRSGNVMVSNSLKSHQ
                     LELRNYTSKKDMSINDIYVGATSEELYFYSKKYGKRVIFIMNNMFNYINGSKLLRFLLE
                     VSNSDFQNITPIMFDNLDSYNHVPTIIYKDIIIKPETWNIRKSEVKTLDSLKNWLSDND
                     VPSLVRMKYTDQIIYLDLSRTIDLTMLFRSIKKHSFIQLLATHSEFVNDTKILELVVPF
                     TRSDVNARQIYHYAQNIYTLEDSDSKEKYFYVKIYVNKQRQTSFLQKEYPLLLNYLKLP
                     ENLQWFYIRYEDDEKDSIRLRIRYVEDKQLVQLYSRFIEWATEARKNIQILGYEISEYI
                     PESARYGGKKYSTIIHSFFYYDSILSLLLQKKTDQAIEVRTSLSIIRMFLMMKLNLQDQ
                     QELMKNLFDGEHKLKYEKEYHNSISLLLDSLCTRNQIDEADTFCVMNMKIITEEVSSVL
                     KQEDLTTDWQRILGSLIHMRCNRVYGINSELERKTMFIVDKVVNSKRYTDMFLEVDNET
                     K"
     aSDomain        complement(13536..13724)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CO204_RS07200_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="5.50E-12"
                     /identifier="RREFam001.1"
                     /label="CO204_RS07200"
                     /locus_tag="CO204_RS07200"
                     /protein_end="233"
                     /protein_start="170"
                     /score="37.2"
                     /tool="antismash"
                     /translation="DIHEDITVKSNQLIDYVINCAEQPICYPTLVDNIAEKFSQSSDGV
                     KKYLQKLIKEEFLITELK"
     misc_feature    14348..14363
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     gene            complement(14389..14622)
                     /gene="mutA'"
                     /locus_tag="CO204_RS07205"
                     /old_locus_tag="CO204_07175"
     CDS             complement(14389..14622)
                     /codon_start=1
                     /gene="mutA_"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038000.1"
                     /locus_tag="CO204_RS07205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07175"
                     /product="mutacin-like lanthipeptide"
                     /protein_id="WP_272943592.1"
                     /sec_met_domain="TIGR03731 (E-value: 4.3e-16, bitscore:
                     55.6, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAAQSFDIRGINMLNTQLLEVLGTKTFDVQEDLFEFNITDTIVL
                     QASDSPDTHSKVGSFNICPPRKISVSFNSYCC"
     gene            complement(14650..14841)
                     /gene="mutA"
                     /gene_synonym="lanA"
                     /locus_tag="CO204_RS07210"
                     /old_locus_tag="CO204_07180"
     CDS             complement(14650..14841)
                     /codon_start=1
                     /gene="mutA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gallidermin"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="lanA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268802.1"
                     /locus_tag="CO204_RS07210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07180"
                     /product="lantibiotic mutacin 1140"
                     /protein_id="WP_002268802.1"
                     /sec_met_domain="Gallidermin (E-value: 1.7e-34, bitscore:
                     114.9, seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 1.3e-13, bitscore:
                     47.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTQLLEVLGTETFDVQEDLFAFDTTDTTIVASNDDPDTRFKSW
                     SLCTPGCARTGSFNSYCC"
     CDS_motif       complement(14719..14841)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSNTQLLEVLGTETFDVQEDLFAFDTTDTTIVASNDDPDTR"
                     /locus_tag="CO204_RS07210_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14650..14718)
                     /prepeptide="core"
                     /locus_tag="CO204_RS07210_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="18.60"
                     /molecular_weight="2264.6"
                     /monoisotopic_mass="2263.0"
                     /core_sequence="FKSWSLCTPGCARTGSFNSYCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSNTQLLEVLGTETFDVQEDLFAFDTTDTTIVASNDDPDTR
                     "
                     /leader_location="[14718:14841](-)"
                     /alternative_weights="2282.6"
                     /alternative_weights="2300.7"
     gene            complement(15429..16265)
                     /locus_tag="CO204_RS07215"
                     /old_locus_tag="CO204_07185"
     CDS             complement(15429..16265)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002289975.1"
                     /locus_tag="CO204_RS07215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07185"
                     /product="XRE/MutR family transcriptional regulator"
                     /protein_id="WP_201031871.1"
                     /sec_met_domain="TIGR01716 (E-value: 1.3e-64, bitscore:
                     214.7, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELGELYRELRIARGLKIKDIACKNLSKSQLSRFENGQTMLAADK
                     LLLAISGIHMSFSEFGYALSHYEESDFFKRGHKLSELYVQKDIKGLKKLLEFNDNHEVF
                     DVYNRLNKLVIQVTIHLLDTDYIISDDDKNFLTTYLYNIEEWTEYELYIFGNTMSILSS
                     DDLIFLGKAFVERDKLYISLPSHKKNAELTFLNLILILLERKKLYQAIYFVENLEKLLN
                     YQDMFAITFLKFLKKIITYFHDKSVDMSELEHYINIVEEINPTIASILKSNLNQLL"
     gene            complement(16541..19159)
                     /gene="alaS"
                     /locus_tag="CO204_RS07220"
                     /old_locus_tag="CO204_07190"
     CDS             complement(16541..19159)
                     /EC_number="6.1.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004813 - alanine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006419 - alanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="alaS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002261891.1"
                     /locus_tag="CO204_RS07220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07190"
                     /product="alanine--tRNA ligase"
                     /protein_id="WP_019313145.1"
                     /transl_table=11
                     /translation="MKQLTSAQVRQMWLDFWKSKDHAIEPSANLVPVNDPTLLWINSGV
                     ATLKKYFDGSVIPENPRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSVGDYFRDDA
                     IKWGFELLTSPEWFDLPKDKLYMTYYPDDKDSYNRWIECGVEPSHLIPIEDNFWEIGAG
                     PSGPDTEIFFDRGEDFDPDHIGVRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKE
                     LPHKNIDTGAGLERLVAVMQGAKTNFETDLFMPIIREIEKLSGKTYDQDGDNMSFKVIA
                     DHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGINEPFLYKLVPTVGKIMES
                     YYPEVLEKQDFIEKIVKREEETFARTIDAGSNMLDQLLADLKVADKDTLEGKDIFRLYD
                     TYGFPVELTEELAEDAGFKIDHQGFQAAMKEQQERARANVVKGGSMGMQNETLSNITEK
                     STFNYEKEALDSSLSVIIADNERIEAVSEGQVLLVFSETPFYAEMGGQVADHGLIKNDK
                     GDTVARVTDVQKAPNGQALHTVDVLGSLSVGTTYHLEIDHERRNRVMKNHTATHLLHAA
                     LHNVIGNHATQAGSLNEVEFLRFDFTHFEAVTPEELRQIEEEVNQQIWKAIPVTTIETD
                     LDTAKEMGAMALFGEKYGKNVRVVSIGDYSVELCGGTHLKNTSEIGIFKIVKEEGIGSG
                     TRRILAVTSKEAFEAYRQEEDMLKEIAVTLKAPQMNQVANKVASLQDQLHKLQKENAEL
                     KERAAAAAAGDIFKDVKEVNGLRYIASQVEVADAGALRTFADKWKQKDYSDVLVLVASI
                     GKKVNVLVASKSKDIHAGNLIKTLAPIVSGRGGGKPDMAMAGGSDASAIKDLIAAVAEN
                     L"
     gene            complement(19374..19874)
                     /locus_tag="CO204_RS07225"
                     /old_locus_tag="CO204_07195"
     CDS             complement(19374..19874)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002278998.1"
                     /locus_tag="CO204_RS07225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07195"
                     /product="LURP-one-related family protein"
                     /protein_id="WP_002265403.1"
                     /transl_table=11
                     /translation="MKSFQIKQKMWSPGGKFTITDELGIPTYQVEGSIFKIPKTFIISD
                     MQGKQISRIQRKTWTFLPKFYVNLHDGSTFFLKRDLSFFKPHYTIKDLDMEIQGDFWDM
                     NFRLLQNDQEVASISQEWLRLTSTYNIEVYDDQYADLVISLVIAIDYVKAIEKSSARSS
                     ASH"
     gene            complement(20113..21114)
                     /gene="prsA"
                     /locus_tag="CO204_RS07230"
                     /old_locus_tag="CO204_07200"
     CDS             complement(20113..21114)
                     /EC_number="5.2.1.8"
                     /codon_start=1
                     /gene="prsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002265402.1"
                     /locus_tag="CO204_RS07230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07200"
                     /product="peptidylprolyl isomerase PrsA"
                     /protein_id="WP_002261893.1"
                     /transl_table=11
                     /translation="MKKRTIATGLVTLLSIVTLAACSKTNQNSKIATMKGDTITVADFY
                     NEVKNSTASKQAVLSLLVSKVFEKQYGDKVSDKEVTKAYNEAAKYYGDSFSSALASRGY
                     TKEDYKKQIRSEKLIEYAVKEEAKKEITDASYKSAYKDYKPEVTAQVIQLDSEDKAKSV
                     LEEAKADGADFAKIAKDNTKGDKTEYSFDSGSTNLPSQVLSAALNLDKDGVSDVIKASD
                     STTYKPVYYIVKITKKTDKNADWKAYKKRLKEIIVSQKLNDSNFRNAVIGKAFKKANVK
                     IKDKAFSEILSQYAAASGSGSSGSTTTTTAASSAATTAADDQTTAAETTAAE"
     gene            complement(21176..21883)
                     /locus_tag="CO204_RS07235"
                     /old_locus_tag="CO204_07205"
     CDS             complement(21176..21883)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014834890.1"
                     /locus_tag="CO204_RS07235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07205"
                     /product="O-methyltransferase"
                     /protein_id="WP_002275166.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 6.7e-31,
                     bitscore: 104.1, seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 5.3e-06, bitscore: 23.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKSYSKNANHNMRRPVIKEDILHYMRHEQKENMGFLKELEIFAH
                     EENIPIIPQETVVYFRFLLQTFQPKNILEIGTAIGFSALLMAENAPQANITTIDRNPEM
                     IALAKENFAKYDSRKQINLLEGDAANILTKLNGNYDFVFMDSAKSKYIVFLPTILECLE
                     IGGIVVLDDVFQGGDIAKPIEEVHRGQRTIYRGLQKLFDATLKHPDLTASLLPLGDGLL
                     LIRKNRKEIGLID"
     gene            complement(21933..22550)
                     /locus_tag="CO204_RS07240"
                     /old_locus_tag="CO204_07210"
     CDS             complement(21933..22550)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803959.1"
                     /locus_tag="CO204_RS07240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_07210"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_019313144.1"
                     /sec_met_domain="HAD_2 (E-value: 3.2e-29, bitscore: 99.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQTAFIWDLDGTLIDSYEAIIEALAVTYRTFGFDFQAEPIRRYI
                     IKESVGKLLDILAKQHGLSSEELKTFFIQEQVKRDDKIKLMPFAKEALQWAKDRGIKQF
                     MYTHKGASTGAVLAELGIVSYFTEILTSVSGFERKPHPQGIFYLLEKYHLDRDRTYYIG
                     DRRLDVEVAENAGIKSINLAQPQSAANQKIDNLQVLTQLKDF"
     misc_feature    22825..22840
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.1"
                     /tool="antismash"
     misc_feature    complement(23367..23382)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.64"
                     /tool="antismash"
     misc_feature    24146..24159
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.91"
                     /tool="antismash"
ORIGIN
        1 gcttgctttg atcttgccat ctttggtcat taaaagataa gtcgtgtctt tgggcaaacg
       61 tttggcttga aaagtatcag ctttttcaat tttatcttct aagcgataga gttcttgttc
      121 tgtctgattg gcaggaatga taagcttggt attgagactt atgacaaaaa cagcccaaat
      181 taggcatagt aaagcaatga aagccaaact aactgtcgca aaatactggg taaaaatcat
      241 ttttaaagag cgacctgatt ttttcatttc catttatagc ctatccccca gaccgtttca
      301 atgggctcaa gcccaatagt tctaaactta gcccgaatat ttttgatatg ctctgctatg
      361 gccgcaggtg ttccccgttc ttcataagca tacaaataat cataaagctg atctttagaa
      421 aaaacttgac cgcgacgctt ggctaacagt tcacagattt catactcaga cttggtcaaa
      481 tcaagtttct ttcccttagc agtaacccgc ttagcagaaa gatcaaaacg gataggctca
      541 agaaccagac tggcatggtg ctcacgcctt tctcgacgca gatgggcatc aacacgcgcc
      601 agcaattcct gcacaccaaa aggcttacaa atataatcat ctgctccata actaagcccc
      661 gtgacaacat ctgcttcctg tgacttagct gtcagaaaaa gaatgggaca gtccaccaaa
      721 ttccgaatgt cccgacaaaa actgagcccg tccacatcag gcatcataat gtccagtaaa
      781 atcaaatcat agtctgctaa ttttgagcgg tcaacctgat tggcactgac aaaagtctcc
      841 accagatagt tttgcagttg caaggtattt tttatcagag ccaaaatatc ttcttcatca
      901 tcaattacca aaatacgggt cattctagga aacctccttc actaggataa catattttat
      961 tcaacattat cttttttatt agcgaaaaag aaataaataa ttgtattaac aagactaaca
     1021 attccaatag ctaaagtgaa tactttcaat cctaaagcag ttagtgataa accacaaaga
     1081 gcacacagta tgctaataaa caaaactaaa atttgataaa ctttcaaaag attaaagttc
     1141 tttagataat aatcacttat tataacaata ctataaataa taatagcgaa aaaaacaaag
     1201 aaccacattt ctggtttatt aaaactattc tggtctccaa ttgggataaa agctatagca
     1261 aaaatccaaa agatagtcaa taaaagcgat accaatgaac ttacaatacg cataatataa
     1321 actcctctat tttttagata ttaaacgata atatagtttg gatgtgcaat gacaaataaa
     1381 ccaataaaag aaaaggtaaa caatcagaca agttccaaca gctcttagaa atagtcctgc
     1441 atcattaaat ccaaaagttg tcattatttt atataaaata ggaagtgcaa agatgagatt
     1501 taatagggca aaagcaatgg gcaagatgaa aacaaagttt atttgaacct taatactgtc
     1561 ttgaatagtt ttatttgtca tacctaattt tatcatggcc ttataatcat ctcggtctcg
     1621 aattccttca gaaagctgtt gataataaat agttatagct gtcaaaattg caaaaatagt
     1681 cccaaaaata ataccaacaa agagtaaacc gccaaataaa gcattaaaca ttgatttgac
     1741 ctgtcttatt gaaactacat tagcactaaa ttgcctgaaa ttagtagtct caagctcatc
     1801 ataaaaatct ttctgattca ttttttttcc tttaacatgg tagcctgcca tcgttcccca
     1861 tgttagctcc tctttcaaaa tagtctgaat tatttctcga ttgtcagtaa ttataaagaa
     1921 attaggctgc atagagcgta gcggagaaaa aataaagttt atccttttaa tttgtttaac
     1981 attggttagt ttaacaccat tagttgtata gctagaggga gcagctgctc catttgaaac
     2041 ataggtgaga atttcatgat tttttaaacg ataatgggta ttattagaag cattaaaaga
     2101 atccaatgaa ataactgtta tttgataatc attagccata ccgccattag gatcaactga
     2161 caaatgactt cctttgatat taccataaac agattgagaa acctttaaat tctggcgatt
     2221 agttagagta acatgatttt ttgtagcgat gtccattaaa ttcggttcaa tatcagttgt
     2281 agatagcacc gtaacatctc taggacttga aagacgaacc atattgtcct ttgcaagata
     2341 gagactagct aagacagata aactaactaa ggtagcggtg ctaaaaatac agatagtcgc
     2401 caaagacaga gcattactgc ggatacggtg aaataaacta gcaatcacaa caaagcgccg
     2461 ttgattatag tagatagctc ttctcttctt tatgacagtc agtaacataa tcacacctga
     2521 cgaaaacgtg caaaaaatac ctagagtaac taagcaggca gcataaatga aacggctgaa
     2581 actggttgtg acattgggac ttgttaaagc aaaatgatat cccattaaca gggcaaaaag
     2641 tccaaaaagt ccaacaaaaa cactagtttt tctaggatta tcacgcttag ctttgctatt
     2701 aaaaataacc gtgatacttt gacgttttaa taatcggtac tctgatagat aaataataaa
     2761 ataaataaaa aaagtaagaa taagtagcca actaatagcc gttaagctat attgttctct
     2821 gacatctcca ataacaatta gatttctgat aaaaagaaaa aatatcttac tgtatacgaa
     2881 accaaagatt aaacctccaa aaaacgttcc tgtaaaaaga tataactttt ccaaatagat
     2941 tatttttaat aattgctttt tccccattcc caacatgaga aaaattccca tattactatt
     3001 acgctcatca cttataaaac gattggcata gcgaccataa agcaacatca gtaatgaaat
     3061 taagataaaa ccaaaaataa gaatatcaat cagtatccta gctgttggaa tgttataaaa
     3121 actagggttg gttaaaaaat taatcaaaac atagttaaaa ccactaaaaa tggtcataat
     3181 agcaaaataa ggtaaggtta atgatttatt tacaataaga ttatgaaagg aaattttggg
     3241 taaaaacata atcaggacaa cctcctacag actggcctga gccataataa tttgatctaa
     3301 aaagccttcc ttggatttac acccacgaac aagttgattg aaaataacac catccttgat
     3361 aaaaagaact cggtttgcat aactagcagc tttaggacta tgagtcacca ttagaattgt
     3421 ctttcgttta gcgttgatgt tagacaacaa attcaagata cgctgagaag tcttagagtc
     3481 caattgtcct gttggctcat cggccaatat caagtctgga ttcataatta aagctctggc
     3541 aatagctaac ctttgttgtt gacctccaga taattcataa ggatatttag atagcaaaga
     3601 ttctatacca acaacagcag ctaaatcacg taatcgtttt tcataggaat tcaccttact
     3661 tcccgaaata ataactggta tcaacagatt gtctttatta ttgaagatat ttaaaagatt
     3721 gaaattttga aaaataaaac caatatgccg acttctaaaa acagcagcct cttcatcttt
     3781 aactttctct aattgatagt tattgaagat gatatgacca ctacttggat aatccataca
     3841 agctaggata ttaaggagag ttgacttccc tgagccagat tcacccataa tagcaataaa
     3901 ttccccttct tgaactgaga acgtaatatc ttttaacgct tcgttagtga ggccttcctg
     3961 agttttatac acctttttga gatgactaac accaatatag gtcatgtttg aaagttctcc
     4021 tttttccttt attcatcact gctacgtcct tgccatctgt cgaaccaaat tatactaagg
     4081 attaaagcca ttaaagttag tggaactgcg acttccagcc agaggagaat ctgctgggca
     4141 aaaataggat tttgatcagg acactgcaac atttcaaaca aggttcccat caaccgtgct
     4201 ggccaagcag caggcacaaa ttgccagata ttatcaccta agcctgttaa aagcaaggcc
     4261 gaaaccagaa cttcaaaaat acctagacca atcgttgccc cgctatcaaa taaaaaagca
     4321 ataaccaaat gcagtaaata taaaataact gttgatacta tcaaaagtaa tcccgcataa
     4381 ccgtaaaagg caagataggg gacatctatt tttgaacgat acaatagacc aaagacagac
     4441 agagctaggc aaacagcgat aatttccatc agcataagat tgacaagctt tataaaataa
     4501 agaacttttc gttgactatt tgctaggaca gtttgaaaat gaccagcttc cgcctctaat
     4561 tcaacagctt tgctgcaagt aatagcaatg actaacggaa aagcaatccc cagcacttgt
     4621 aaataaccac ttgtaatact cccccaagaa taagcaggtg tcaccagacc aaagacagcc
     4681 gttaaaacag cgatgccaac tggtaaaata acatgtatcc aaggcaaaaa ggtacggtta
     4741 tattttaaaa actctgccca aatcaattta accattactt gacctcctgt ttttcaaacc
     4801 aaagagccgt cagccaggtc agtcctgcaa aaaggataag cgccaaagtt aaactgagca
     4861 taatggacca attgctggtt gctaatagcg gtgctgcggc ttctgatcca gctttcagac
     4921 cattgggata tattttcata agaggtatca tcaatcgtat gctccaagca taaggacaca
     4981 gcaaccaata agcagtcgtt gaaaaagcaa ttcccaaaat aacattagct gtgaaattga
     5041 ctaacacggt gataactagg cccaatttct ttgctagcca taaacaaaat ggaagctgcc
     5101 aaagtacact gagcaataag accatagaag caagaagcat ttgactaata aggtaagttt
     5161 ctccataatg tggaaaaata aaatatttca acaagactaa aataaaacaa tgcaagaagc
     5221 tgctcagagt caaataataa gccaaagtca gcactttatt tatccaaaat tttcttaaag
     5281 aaatgggcaa aggaaagatt gctcgataat gcagcttttt ttcttcgtaa gtatttatta
     5341 aagcagcaaa taaggtcagt agtcctggaa aaatcatgat ataccaccaa ttataggcat
     5401 ccgtaatcaa atactgaggt aacataaaac catgtattac taccaatagt ggaccaagaa
     5461 ataataattt ctttgccatc gtacgcttca gttttaatct ttctgcctga aacatgccca
     5521 gcatatcact cacctcctcg gtatctcata accacatcag taaaaagttt ttccaagtct
     5581 tcatcttggt gaattctatc ctgataaccc agtacgccat tagcaatgat accaatatga
     5641 tccgctgtca tctgaatctc agataagata tgactggaaa taataactgt aattccttgt
     5701 gtagggaagg aacgaataag attacgcaac tcctgaatac caataggatc aagtccatta
     5761 gtcggttcat ccagaatcaa aagttgaggt gagttcaaaa gtgcgatagc aatacccaga
     5821 cgctgcttca tgcccataga aaattgccct gctctttttt tacccgtatt ggttagatcc
     5881 actattttta aaacctcatc aatgcgacta tcaggtaaac ccagcatcaa ggttcttacc
     5941 tttaaatttt cacgcgcagt caggttttca taaagtggcg gtgattcaat cagagccccg
     6001 atattttcca aatccttgcg gctccaatcg tgtccgtcta taagaatgtg accagatgtc
     6061 tttcttagca ttccagtaat cattttaagt gttgtcgatt tgccggaacc attaggcccc
     6121 agcaaaccat aaattgaacg acgttcaact ttcaaattca attggttaac cgctgtttgc
     6181 ttcccaaact gtttggttaa atttttcgtc tctagcatat aatccattat gatatcctcc
     6241 ttctctgctt ttagtataaa aaacaaattt aaggacttta tcaggaaaat caaaagagct
     6301 tgagtaaaaa ctcatcaaat agtaaaaagc ttaaaatcaa attattagga atattgattt
     6361 taagcttatt tatatatcac aatatttaat tttcgaccag aaactgatct ttcactcaga
     6421 tttcttcgac ttttctatta gaatccgctc ctcaaaattt ctagtttttt atcagccaat
     6481 cggtaaacga tactactggg agttattcta tttagattat gaataacttc aataacaatt
     6541 tgcttgtgtg attcagcata agcagcaatt tttaatttta ttttaagaca agtctcttca
     6601 tcaatattgg caaaagattc atctaataat aaaacatctc ctgctttcag taatcctctt
     6661 gcaagtgaga tccgttgcat ctgacctcca gagaggttac caccatattc atcaacctta
     6721 gaatctaatt ttcgcggtaa atttctaata agttctgata attctacagt atcaagaaca
     6781 ttccaaagac tagtttctgt atgctgttgc tgattaaagt ctaatagttc acgaattgtc
     6841 ccagaaagaa ttgttggttc ttgagataca tagcttatct tatttcgcaa agtcttaata
     6901 ttcaattctt ctaaatctat tccgtttatt aagattcgtc cttttgatgg tacataatta
     6961 tgttctaaaa gatcaagtaa ggttgatttc ccaactccac tttcaccaac aatggaaata
     7021 taagtacctt tttgaaaagt taaattcaca ttttcaataa tattttcttg gttatcataa
     7081 gcaaatgaaa cattatcaaa cgcgatatta attatttcat caattttctt gattccattt
     7141 ttttctggaa tagcttgatt atactccaaa agacgttcca cgccgccatt aagcatcccc
     7201 atatgagcaa ctaattgtga taattgcata attggattaa ttaattgtgt catataaaca
     7261 acaaaaatag ttgctgaacc tacagtgaga tttcctgaac gtacttctgt atttcctagc
     7321 caaacaacaa ttataatcat aaaaagaatt aagatattta aaaaaggaga gtaaatgcta
     7381 aaaattttta ttctatttaa gatatcttga aataattggc gattttgctc atcaaatttt
     7441 tgaaaggcat aatcttgagc attatagctt tttattgttt tgacttgtcc tctcaactgt
     7501 gaggcaatat taataagttc agctttgtct tcctggattc ttttacttat tttgcttaat
     7561 attctagaaa agggttgcat aatgaacaat aaaagaaagc aaatccctat aacttctaaa
     7621 gacattttac tattaataac aaatagcata actaaggatc ctgatccaac aataactgaa
     7681 tttattgatt gaggaatagt agaaattata aaattttcta tcagttcact atcattaata
     7741 aggtggcctg ccatttcaga agaatcatct ttactatctg tccaatcaga aatttttttc
     7801 caaatattat ttcgactgtt aaacactact tgattaccaa tcaatgaaat tagatactgt
     7861 gaaccagcat ctatgataaa aagaactaat cccaaaacaa gaaacaagaa caaattatta
     7921 aaagacgatt tgccgtcaac taaattctta agtaagtagg tgattcgtag agtaattaag
     7981 cctgtcataa ttgaaaatat acaaccaata agataaagaa ttttttcttt tttactaatc
     8041 tgcaaaactt ctaaccactt catttagtaa cctcgcaaag ctttgtaagt gcttatttct
     8101 ttataaccat cactagtata attaacttga tttagtagaa tacttctagc ttttgaagag
     8161 tctccttgaa gatggtagtt actaataatt tctgcaagct ctccagaaac ttttcctgtt
     8221 gaaatagaag taccatctgc ataatcataa tttccattat tacttgttga taatacttgt
     8281 tctttcataa aaagcttctg attataccac tcttcttgac catattggtc tagtaaagtt
     8341 gttccaccac caggagccaa aataaaattg tcctggtatt gattatagta attactaaaa
     8401 gatgatcttt gattattatt atcagaagag ccaactgcaa tagcattagg taaaacagaa
     8461 ggataatctt caaccgtgtc attttgagac atatcttgtc ctgaatgctg actattataa
     8521 taagttttaa cctctccgtt gtcatcactt aatccatcat tacctgtggc tgctacaaca
     8581 atgacattat gtcttgtggc ataatcaatg gcaaacttat atcctaatgc ttcggcagac
     8641 tcccaaatat caccattagg aatcttaata tattgcccca aacttagatt aataacatta
     8701 gcaccattat ttgttgcatc aataattgct tttaaaatcc agcactcctt tgattttgat
     8761 tttccaaaaa ctctatagac aagaaggttc gttcctgggg acacaccaaa gatttgacca
     8821 tttgcagcaa tttgcccagc aactgctgtt ccatggcctt ttttatcatc aatatcatta
     8881 atacttccag tttcactgct ttcactatta tcatatcctc cagcaggcac aaaatttttt
     8941 gaacgactat caatcattcc tgtaaaagca ttatggtcta catcaatccc agaatcaact
     9001 aaagcaactg ttacattttt tcgattttct ttatttaatg aatatgaaac accattatta
     9061 gtaatttttt gcatatccca ctgataagaa aaaagctgag gcaattgtat tgtctggtta
     9121 atatatgttg aaggaactct agtcgtgata ttctgtgatg tatcagccat attctggata
     9181 cttttaatat ttgacagctt tttaatctga tcaatgttaa catctccttg agcttcaata
     9241 tatccaattt ccgcaatatg gctattgact gtaactccta aattattcaa gtcattaaca
     9301 gtttgttcac tattatttga tataattgta tattcagcag ctttagcttt aggataaaag
     9361 aaaaagaaag ttagaaagat tattactagt aatcctttct tcttcatact cttacctctc
     9421 ttcttgtaaa ttttctaaaa caactcgttg caattcatcc aaacttggaa ttgcaatatt
     9481 ctttttcatc tttccactgg ctaattcaaa agattctgat tcttgtccaa caattacctt
     9541 atattgggtt ccagataaaa cttcaacatt tttttgaact actggatttt cccacataat
     9601 attattcatg caaggataaa ttaaaactgg cttgctagaa gaaagaagag ttgttgtcat
     9661 aaagttatct gcaataccat tagcaacttt tccaattata tttgctgtag caggtaagac
     9721 aactgttatg tctgcccagc gagttaaagc tatgtgattc ttttgcttat ctgtaaagga
     9781 aacttcatca gtatacactt tctcacacaa ttgtgtaata gcagcaacgg gaagcatctt
     9841 cgcagcatta tcagagacaa taactcgaac atgcttaaag cgcacagtca aaaacgtaat
     9901 atattcagtt atccctaaca aggctccaga acctgttaga cacaagagaa tttttttctc
     9961 tgtattttgt tcttccataa ttattcctcc gttcagttaa ttaagttaaa agaaaaattt
    10021 tattccactc tgaaactttt ccagcattta caatattaca atattccatc aaaactaata
    10081 gaacaccaac agttccacta agaagaccaa aattatccca ataagttaat ctctcttcag
    10141 tattatcaat attatcttct atatctttaa atccaaacat attttcagaa ttgtacacaa
    10201 ttaatatttt atcaatttct tcttctgctt taactaaaaa tattgattct ttagttcttt
    10261 gatattgcag aagaaagaaa tttgcttttc cagcaaaccc atgacaaaat gttggacttt
    10321 ccattttctc ataatcatct tttatgatgg atggtataac tttctgagca gtttcacaaa
    10381 tcttctgatt tgagagtact tttcccataa gaaaaagtgt actataaatg ccattatctc
    10441 cataacacca gccatttcgt aatataaaag aaccctcttt acgaagtaaa tcatatcgta
    10501 ttggccatcg tagcccctca tctcttagtt gagcatatct ttttataaaa tgataagtct
    10561 cctgaagttt ctcagcattt cttgtgttct gtgggtacct ctgctgataa agagacataa
    10621 ttgttgtagg acctaataat ccatgagcta aaccaaagtt tatatttccc tttaaataat
    10681 attgcttttc agattctaaa aattgatatt ttggttgcac tcgccagcct tgttccaaag
    10741 ctttataaaa tacttctaaa atcatttcaa caattcgcca atcttcagag gattctcttt
    10801 ccatcagata acgagctact ccagcatttc cagaaattac atcataattc ataggatttg
    10861 tatactcttc actattacaa tcagcaaggt tccgcttaac gttctgacaa attttactgt
    10921 caatttgatt aagaagtttt tgataatatt taccgttatt agagacataa ttaatagcaa
    10981 aacctacccc agctaaacca tcaaataaag aggatttatc tgctatttga ttaatataat
    11041 aacttataag tccgatcaat gactgctttt gcggctttaa gtttactcct tctaaattct
    11101 catactcttg ataaaagatt aataaagaag ttattcccga agacaaagaa agtaaattcc
    11161 aaaaatctgt ttgttttact tgactgattt tttttaatac ctcttgataa tcaaataaat
    11221 aagtttgctc tgttagaata tttttaattt tttcgacacg tttactttgt ctcattatcc
    11281 acctccaaaa acatatctgt atatcttttt gaattaacaa ctttgtcaac aataaacatt
    11341 gtttttcttt ctaactcact attaattcca tatactcgat tacatcgcat atgaataaga
    11401 cttcccagaa ttctctgcca atctgttgtt aagtcctctt gtttaagaac tgaactaact
    11461 tcttcagtga ttattttcat attcattaca cagaaagtat cagcttcatc tatctgattt
    11521 cttgtacata aactatcaag taataaactt attgaattat gatattcctt ttcatattta
    11581 agtttatgtt ctccatcaaa caaatttttc atgagttcct gttgatcttg caagtttaat
    11641 ttcatcatta aaaacatgcg aataatactg agagaagttc tcacttcaat agcttgatct
    11701 gttttctttt gtaaaagtaa actcaaaata ctatcataat agaaaaaaga atggataatt
    11761 gtggaatatt tttttcctcc atatcttgct gattcaggga tgtattcact aatttcataa
    11821 cctaaaattt gtatattttt ccgtgcttct gtcgcccact ctataaagcg tgaataaagt
    11881 tgaactaatt gtttatcttc tacatatctg attctgagac gtatgctgtc tttttcatca
    11941 tcttcatatc taatatagaa ccattgcaaa ttttcaggga gtttcaaata gtttaataat
    12001 aaaggatatt ctttttgtaa gaaagaagtt tgtcgttgtt tgttaacata aattttaacg
    12061 taaaaatatt tttctttact atctgaatcc tccaaagtat aaatattctg ggcataatga
    12121 taaatctggc gagcattgac atcactcctt gtaaaaggca caactagctc caaaatcttc
    12181 gtatcgttta caaattcgga atgagtagct aacaattgta taaaactgtg ttttttaata
    12241 ctccgaaata acatagttaa atcaatagtc cgactcaaat ccaagtaaat aatttgatca
    12301 gtatatttca tccgcacaag agatggaaca tcattatcag atagccaatt tttgagagaa
    12361 tctaaagtct taacttcaga ttttctaata ttccatgttt ctggtttaat aataatgtct
    12421 ttataaatga tagtaggcac atgattataa gaatccagat tatcaaacat aatcggagta
    12481 atattttgaa agtcagaatt tgaaacttct agtaaaaaac gtaaaagttt ggaaccattt
    12541 atataattaa acatattatt cattataaaa ataactcttt ttccatattt tttagaataa
    12601 aagtataatt cctcactggt tgcacctaca taaatatcat tgatactcat atcttttttt
    12661 gaagtatagt ttctcaactc caactgatgg cttttaagac tgttactgac cataacatta
    12721 ccactcctcc caaaatatgg cacttcattt aattgagtaa taatagtatt aggataggct
    12781 ttagcaaaaa tttctttcgt tttatttaca ttttctgtga ttatcgtatt cggcaattta
    12841 gcatgaaaac gtccgaaggt atctccaatc atcggtgaaa cacctaaacc actaacctcc
    12901 aattttctat ttttaaaatc atagaaacag tatagttccc ctgatatctg ctgttcctta
    12961 tcaaaatcta gatcttttaa atcatcatca ttcagaataa tttctttacc atctcttaaa
    13021 gatttttcaa attttctctg caaaaattct gttatttttt gattccgact atctccatta
    13081 ttttgtttaa aatcttttgt ctgactatac ccttttggaa agccaagtcc actagtagaa
    13141 ttcaaaagta attgaagagg tactaactgt tcatatccat atctggaaat aaatttctca
    13201 tggtaatttc taatttcttt ccgactatta atacctggtg aaaaagaact tagtactttt
    13261 aaaatattct gaagagaatc cttgatatga tgagataact ccaactctgc atgatcataa
    13321 agatcaaccc gcaaatatgc attagtttct gctatttggc tcatcttatt ttctaaagct
    13381 aaaatcaaat tgttgccctc accaatgtca cagtcagtat agtcctgaat cattgccttt
    13441 atctcagtca acttttcaag taattctagg ttattttgag ttctttctaa gatattaata
    13501 aaccaatcca aaggattgtc ttcaatcaaa ctaaatttta actcagtgat caaaaactct
    13561 tctttgatta atttttgtaa atattttttt acaccatcac tagactgaga aaatttctcg
    13621 gcaatattat caactaatgt tgggtaacaa attggttgtt ctgcacaatt aataacgtaa
    13681 tctataagct gattagattt aactgtgatg tcctcatgaa tatcagaacg tgaattcata
    13741 agaccaaaat gacttcgcgt atccaaaagc caaaaattat ctgacttttg caaagcatta
    13801 ttagcaacta cttttaaagt atttaaaatt tcaggcatac tttctagttt atctgctact
    13861 ttataagccc aaaaaagatc aatattaata gatttttcat aacgagactt ttctttttta
    13921 aggtaagccg aaaaagcacc tactccgatg gacgaaaaca agccaaacgg agttgatctc
    13981 gtgttataac gggcatagta ttgaaaaata gtctctcttg cattcttttt atccttagta
    14041 ctcgcagtat gattcttaag tttatttatg gctgctctaa gagatgaaga ggccaaatat
    14101 actccttcag caaatatcgg atcactatgt agtaactcaa tgggatccat cgtatcagtt
    14161 atactaaaaa aattagaaaa gttgcctaat ggttttctgt acataaaata atcttgaaat
    14221 tgaaaatcgt tcatctcttc tcctaacatg actgtcaacc tagtaataat tcatctaaat
    14281 attcatcaaa tttagattta attgtcttta taaatttgat tctcttccaa tatcaacata
    14341 tgataatgtc acgaccaagt ttcctatcaa tttaagtata atttatagtt aacaacagta
    14401 actattgaaa ctgacggaga tctttcgagg agggcagata ttgaaactac ccactttact
    14461 atgagtatct ggactatcac tagcctgcag tacaatagta tctgttatat taaactcaaa
    14521 taaatcttct tgaacatcaa aagttttagt accaaggact tctaataatt gtgtatttaa
    14581 catattaata cctctaatat caaaagattg tgccgctaac atgcggcaca atctaaatct
    14641 tttatacaat cagcaacagt aactattgaa actacctgtc cttgcacaac caggcgtaca
    14701 aaggctccaa cttttgaaac gagtatctgg atcgtcgttg cttgccacaa tagtagtatc
    14761 tgttgtatca aaagcaaaga gatcttcttg aacatcaaaa gtttcagtac caaggacttc
    14821 taataattgt gtgtttgaca taatatcctc ctttttcatg tgtgtaactg aacataaatt
    14881 gttcagtaga agcatatcag aaaactttta acggtaatct gataatagtt attatataat
    14941 tataattata tacttattaa gtagtacatc tacagataac taatgctagc agaaatatct
    15001 aagataacaa caaaatctgt tgtaatagta aatcactatt actgagtaaa catatattta
    15061 caataatata ataccaccat tagcctctat ttttttaaaa ttgcaaatct gcttttttaa
    15121 aattatttta tcccatattt gcaaatatag gaatattacc tttttgaatc ttataataaa
    15181 ttaaaggagg aaatattatg gttaaacgta ttattttact aactctttgt ttaccacttc
    15241 tcttattacc acttttataa taagaaagga tgaactgtca ctatgtttca ttactataac
    15301 tccatgataa catagcttct aatcacaaaa aaagcagcga tagcataacc gttgcttttt
    15361 cattatctcc acatttaatg aatatgaaag atataaaatt tatcaagatg gctttaatgg
    15421 ctaaaacttt ataaaagctg attcaaatta gatttaagaa ttgaagcaat cgtaggattt
    15481 atttcttcaa ctatattaat ataatgttct aattcagaca tatctactga cttatcatga
    15541 aagtaagtaa taattttttt taaaaatttt aaaaatgtta ttgcaaacat atcttggtaa
    15601 tttaataatt tctctaaatt ctctacaaaa tagattgctt gatataattt ttttctttca
    15661 agcaaaatta agattaaatt taaaaaagtt aactctgcat ttttcttatg actaggaaga
    15721 gatatataca acttatcacg ttctacaaaa gcttttccca aaaaaattaa atcatcagat
    15781 gacaatatag acatagtatt cccaaagata taaagttcat actcagtcca ctcttcaata
    15841 ttatatagat aagttgttaa aaaattctta tcatcatctg atattatgta atcagtatct
    15901 agcaaatgaa tagtaacttg aataaccaat ttatttaaac gattgtagac atcaaatacc
    15961 tcatgattgt cattaaattc taataacttt tttaatcctt tgatatcttt ctggacatat
    16021 aattctgata acttatgacc ccttttgaaa aaatcactct cctcataatg gctcaaagca
    16081 tatccaaatt ccgaaaagct catatgaatt cccgaaatag ctaatagcaa tttatcagct
    16141 gccaacatgg tttgtccatt ttcaaatcta gagagttgtg acttggacag atttttacaa
    16201 gctatatctt ttatcttcaa acctctagca attcttaatt ctcgataaag ttcacctaat
    16261 tccattgatt gatttacttt caaaatagtc tcctttcatt ataaaggccc tcttctgtgc
    16321 tattatatca ctttttcaat tcttcgttta tcttttttag ttttgaatca ttcccgcttt
    16381 tagtataaaa aacaaattta aggaaatgat aaggatttgt tcatcacaaa aaaacatcca
    16441 aatattaagt gacatttggg cattattaaa aaactcccta gtttttatac tgaggagtgt
    16501 acctgataag tcattgaatg attttctgac aagataaatt ttacaaattc tctgctactg
    16561 cggcaatcaa atccttgatg gctgaggcat ctgaaccacc tgccatggcc atgtctggtt
    16621 taccaccacc acgacctgaa acgattggtg ccaaagtctt gatgagatta ccagcatgga
    16681 tatccttaga cttgctagca acaagaacat tgaccttttt accaatgctg gcaactaaaa
    16741 caagaacgtc ggagtaatct ttttgtttcc atttatcagc aaaggtgcga agggcacccg
    16801 catcggcaac ttctacttgg ctcgcaatat agcgaagacc attcacttct ttaacatctt
    16861 tgaagatatc accagctgca gcggctgctg ccctttcttt tagctctgca ttctcctttt
    16921 gcagtttatg caattggtct tgcagcgaag ctaccttgtt ggctacctga ttcatttgag
    16981 gcgctttaag cgttacggca atttctttaa gcatgtcttc ttcttggcgg taggcttcaa
    17041 aggcttcctt actggtcaca gctaggatac ggcgagttcc tgaaccaata ccttcttctt
    17101 tgacaatctt gaagatgcca atttcagaag tatttttaag atgggtccca ccacaaagtt
    17161 caacagaata gtcgccgata gaaaccacac gcacattttt accgtatttt tcaccaaaga
    17221 gagccatggc acccatttcc ttggcggtat caaggtctgt ttcaatggtt gtcacaggaa
    17281 tagccttcca gatttgttgg ttgacttctt cttcaatttg acggagctct tctggcgtta
    17341 ccgcttcaaa atgggtgaag tcaaaacgca aaaattccac ttcatttaga gaacctgcct
    17401 gagtggcgtg attgccaatg acattgtgca gcgccgcatg aagaagatga gtagccgtat
    17461 gatttttcat gacccggttg cgacgttcat gatcaatttc tagatgataa gttgtcccta
    17521 ctgacaagct gcccaaaaca tcaactgtgt gaagggcttg accatttggc gctttttgca
    17581 catctgtcac acgagcaacg gtgtctccct tatcattctt gataagccca tggtcagcta
    17641 cttgtccacc catttcagca tagaatggtg tctccgaaaa aacaagcaga acttggcctt
    17701 ctgatactgc ttctatacgc tcattgtcag caatgatgac agaaagactg ctgtcaagtg
    17761 cttctttttc ataattgaaa gtagattttt cggtaatgtt tgacagagtt tcattttgca
    17821 tacccatgga gccgcctttg acaacattgg cacgcgcacg ttcttgttgt tctttcatag
    17881 cagcttggaa gccttgatga tctatcttga agcctgcatc ctctgccaat tcttcggtca
    17941 attctactgg gaagccataa gtgtcataaa gtctgaaaat atcttttcct tcaagcgtat
    18001 ctttatcagc aaccttcaaa tcagccaaaa gttgatctaa catgtttgag cccgcatcaa
    18061 tggtccgtgc aaaggtctct tcttcacgtt tgacaatttt ttcaataaaa tcttgttttt
    18121 caagcacttc tggatagtag gattccataa tcttaccaac agttggaacc aatttataca
    18181 agaagggttc attgatgcct aaacgacggc catgcataac tgcacgacga aggagacggc
    18241 gaaggacata accacggcct tcatttcccg gaagggcacc atcaccaata gcaaatgaga
    18301 gagaacgaat atggtctgca atgaccttga agctcatatt gtcgccatct tggtcatacg
    18361 ttttaccaga taatttttca atctcacgga tgattggcat gaaaagatcc gtttcaaaat
    18421 tagtttttgc cccttgcata accgcaacca agcgctctaa accagcaccc gtatcaatgt
    18481 ttttatgagg caattccttg tattcagaac gagggacagc tggatcagca ttgaattgcg
    18541 aaagcacgat attccaaatt tcaatgtagc gatcattttc aatatcctcg gccaagaggc
    18601 gcacaccaat atggtctgga tcaaaatctt ctccacgatc aaagaaaatt tctgtgtctg
    18661 gtcctgaagg tccagcgcca atttcccaga agttatcttc aataggaatc aggtgacttg
    18721 gctcaacacc gcattcaatc cagcgattgt aagaatcctt atcatctgga tagtaggtca
    18781 tatagagctt atcttttggc aagtcaaacc attcaggact agtcaaaagt tcaaagcccc
    18841 atttgatagc atcatcacgg aagtaatctc caacagaaaa attccccagc atctcaaaca
    18901 tagtatgatg gcgagctgtt tttccaacat tttcaatatc attagtgcgg atggcctttt
    18961 gcgcattggt aatgcgtggg ttttcaggaa taacagaacc atcaaaatat tttttcagcg
    19021 ttgcgacacc tgaattaatc cacagtagtg tgggatcatt aacagggacg agattagccg
    19081 acggttcgat agcatggtcc tttgatttcc aaaaatctaa ccacatttgg cggacttgag
    19141 ctgatgttaa ttgtttcata tttagatata gagtccgact gtaattgaac agaaaattaa
    19201 gaatctgacg acagatactt gtatcttagg cagactatct atttttcgac aatcacagga
    19261 cgaattccct ttcctttctt ttcattaaaa ataattgaac gagacaaaca gaaaaagcac
    19321 ctgttaatag gatgaattca gttttttctt taaagatcac agatagtcta cagttaatgt
    19381 gatgccgatg atcttgcaga gcttttttca atcgccttga catagtcaat agcaatgacc
    19441 agtgatatca ctaagtctgc atattgatca tcatatactt caatattata agtcgaggtc
    19501 aggcgcagcc attcctgaga aatactagca acttcctgat cattttggag gagccgaaaa
    19561 ttcatatccc aaaaatcacc ttgaatttcc atgtctaaat ctttaattgt atagtgaggt
    19621 ttaaaaaatg acagatctct tttcaggaaa aatgtagaac catcgtgtaa attgacataa
    19681 aacttaggaa ggaaggtcca agttttcctt tggatacgac tgatctgttt accctgcata
    19741 tccgaaatga taaatgtctt tggaatttta aagatggagc cctctacttg ataagttggg
    19801 attcctagct catctgtaat ggtaaattta ccgcctggcg accacatttt ttgtttgatt
    19861 tgaaaactct tcatagcttt ttctccaaaa aacaagttca ctgtaagaag ggcgaagaaa
    19921 ccgcggtacc accttcattc aatgaacttt tcattcttat tatgttattc tgtttatcaa
    19981 tcaagcagcc aaatttttct atttgcatag ctcacatcaa ccgctatttt tctgaagcaa
    20041 atgagagaaa aattattctt gacagaacaa ttatactgtc tttttcaaca ttcgtcaatc
    20101 tttacaagtc ctttattctg ctgctgttgt ctctgctgct gttgtttgat catcagcggc
    20161 cgttgttgca gcgcttgaag cggctgttgt agtcgtcgtt gaccctgaag agccacttcc
    20221 gcttgctgcc gcatattgtg ataagatctc actaaaggcc ttatctttaa ttttgacatt
    20281 agctttctta aaggcttttc caataacagc attacggaaa ttactgtcat ttaatttttg
    20341 agaaacgata atttctttca gacgtttctt ataagctttc caatcggcgt ttttgtcagt
    20401 ctttttcgtg attttgacaa tatagtaaac aggtttataa gtcgttgaat cagacgcctt
    20461 aatgacatct gaaacgccat ccttatcaag attcaaagca gccgataaaa cttgactagg
    20521 aagattagtt gagcctgaat caaagctata ttcggtctta tctcctttgg tattatcttt
    20581 agcaatttta gcaaagtctg caccatctgc cttagcttct tctaaaacag attttgcctt
    20641 atcttcacta tccaattgaa tcacttgagc tgttacttcc ggtttataat ccttataagc
    20701 tgacttataa ctagcgtctg ttatttcttt cttagcttct tccttaacag catattctat
    20761 taatttttca gaacgaattt gtttcttata atcttctttt gtgtagccgc gtgaagccaa
    20821 agcacttgag aaagaatcac catagtactt agcagcttca ttataagctt ttgttacttc
    20881 cttatcagaa accttatcgc cgtattgttt ttcaaaaact tttgaaacta agagagataa
    20941 tacagcctgc ttagaagctg ttgaattctt tacttcatta taaaaatctg caacagtaat
    21001 agtatcaccc ttcattgtag caattttact gttttggttt gtttttgaac aagccgctaa
    21061 agtcacaata gaaagcaaag tcacaagtcc tgtagcaatc gtacgttttt tcattcttga
    21121 taaactcctt tttgtcatta acccttttat tatatcataa tttcttaaaa atgacttaat
    21181 caatcaaacc aatctctttg cggtttttac gaatcagcag cagaccatca ccaagcggca
    21241 gcaaactggc agtcaaatca ggatgtttca gtgttgcgtc aaatagcttt tgcaaaccac
    21301 gataaatggt acgctggccg cgatgaactt cttcaattgg cttagcaata tcaccgcctt
    21361 gaaaaacatc atctaaaaca acgataccgc caatctctaa acactctaga atagttggta
    21421 aaaaaacaat atattttgac tttgctgaat ccataaaaac gaaatcgtaa ttcccattca
    21481 gtttagttaa aatattggca gcatctcctt ctagcaagtt aatctgcttt cgactatcat
    21541 attttgcaaa gttttccttg gctagagcaa tcatttcagg attacggtca atggtcgtaa
    21601 tatttgcttg cggagcattc tcagccatca aaagtgctga aaaaccaata gctgtcccaa
    21661 tttctaagat attcttaggc tgaaaagtct gcaagagaaa acgaaaatac acaacagttt
    21721 cttggggaat gattggaata ttctcctcat gagcaaatat ttccagttcc tttaaaaagc
    21781 ccatattttc cttttgttca tgacgcatgt agtgaagaat gtcttcctta ataacaggac
    21841 gtcgcatgtt gtgatttgca tttttactgt aagatttaac catgattttt attataacaa
    21901 aaattcccta acttaggtta aggaagatat ttttagaaat ctttcagctg agtcaagact
    21961 tgtagattat caattttctg attagcagct gactggggct gggctagatt aatagatttg
    22021 atgcctgcat tttcagcaac ttctacatct agacgtctat cgccaatata gtaagttctg
    22081 tctctatcca aatgatattt ctccagcaga taaaagattc cctgtggatg tggtttgcgt
    22141 tcaaatcccg acacacttgt caatatttca gtaaaataag agacaattcc taattctgcc
    22201 agcaccgctc cagtagaggc acctttatgg gtatacataa attgcttaat tcctctgtct
    22261 ttggcccact gcagcgcttc tttggcaaag ggcatcaact taatcttatc atcacgctta
    22321 acttgctctt ggatgaagaa agtttttaat tcttcagaag aaaggccgtg ctgtttcgcc
    22381 agtatgtcta agagtttccc aaccgattct ttgataatat aacgtcgaat aggctctgct
    22441 tgaaaatcaa aaccaaaagt cctataagtg accgcaagag cctctataat ggcctcataa
    22501 gaatcaatca gtgtcccatc taaatcccaa ataaaagctg tttgtggcat attttctcca
    22561 tttcattaaa atttcccacc atcaaaaata atgaatagct tatttgatta ctttctatat
    22621 ctaaatctat tcaataacgt gctaattgaa tgtcttgccc acgataagtt tccctaacaa
    22681 ttcctcccaa ttgaccgccg attttttcaa gcagagaacg actgggaaaa gtgttttcat
    22741 cctaagatag cttttaagct atcttattaa tcaattcctt tttcgaccaa ctcttccaac
    22801 tctattaacc gttcttcaaa gactttgaag gcttggtcaa tataggtcga ctcagtcata
    22861 tcaagacctg ctttagcaat aacattgaga ggatagtctg aattgccagc tttgagataa
    22921 ttgagatatt tgtccttatc ttcttgattg ccatgaacaa ttttgtgagc caaaaaacta
    22981 gctgcagcaa agcctgtggc atactgataa acataaaaat tgtaatagaa atgcggaatc
    23041 ctagcccatt catactgaat ttccggatta tttttcttgc ttaaaccata gtatttttca
    23101 ttgagatccg catagagatt attcaaataa tcactggtca aaacttcacc tgcttgatca
    23161 gccctataaa tcaagtcttc aaattctgca aattgtgttt ggcggaaaac cgttcctttg
    23221 aaaccatcaa gataatgatt caaaatcgca aaacgttgtt tctcatctgt tgcttccttg
    23281 agcagtgtct ctgtcaaaat attttcattg gttgtcgaag caatttctgc cagaaaaata
    23341 gaataatcac cataaacata gggttggttt tcacgtgtaa aagtagaatg caaagaatgt
    23401 cctgtttcat gcacaagagt gaagaggtta tccaaagtat cctgccagtt aagcaatata
    23461 aaagcattgg tgtcatagga accacctgaa taagcgcctg aacgcttgcc tttattgact
    23521 cgtacatcaa tccaacgctc cctaaatgca cgatgcacac gctcagcata gtctcgccca
    23581 aaaatagcta acacttcttc tgctttgtcc aaggctgctt cataagtaaa agtcatatcc
    23641 atttctgaga gtggtacgta aatatcatac atcttaagat catcaaggcc taaaacgttt
    23701 tgccttagct tcacataacg ctgtaacaaa ggtaagtgat tatggaccgc ttctactaaa
    23761 gtgtcataaa cagtttcggg aataaaatta gctgccagag cagcttcacg cgcactctta
    23821 tagtttctga ttttcgcttg aaaattatta actttaacat tggtttgcag cgttttagca
    23881 taggtgtgtt gatactgctc ataaatgctg tacatggcct tataagcttc ttgtcgaact
    23941 ttgcggtttt tggattccat caaactgatg aaattaccat gagatagttc aacttcttct
    24001 cctgtctcgt cttttaccca aggaaagata atatcggcat tgtcaagaat ttcaaaggtt
    24061 tcaccagcag caccaaaaat ttcactggct tcagccaaaa gtgcctcttc cttttgagaa
    24121 agaacatgct ttttttgttt aaataatttt tcaaaaaaat gttgataagg caataaatcc
    24181 ggacaatctg ccaaaaaatc ctgatatttt tctgttgata acagcataaa ttca
//
