LOCUS       NZ_CP023477            22499 bp    DNA     circular CON 18-JUL-2024
DEFINITION  Streptococcus mutans strain LAR01 chromosome, complete genome.
ACCESSION   NZ_CP023477
VERSION     NZ_CP023477.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2088369)
  AUTHORS   Abranches,J., Lemos,J., Kajfasz,J. and Aviles-Reyes,A.
  TITLE     Whole genome sequence and phenotypic characterization of a Cbm+
            serotype e strain of Streptococcus mutans
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2088369)
  AUTHORS   Abranches,J., Lemos,J., Kajfasz,J. and Aviles-Reyes,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-SEP-2017) Oral Biology, University of Florida, 1395
            Center Drive POBOX 100424, Gainesville, FL 32610, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: celera v. 9/01/15
            Genome Coverage                   :: missing
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002995555.1-RS_2024_07_18
            Annotation Date                   :: 07/18/2024 01:10:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,086
            CDSs (total)                      :: 2,002
            Genes (coding)                    :: 1,930
            CDSs (with protein)               :: 1,930
            Genes (RNA)                       :: 84
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 41 of 72
            Pseudo Genes (incomplete)         :: 35 of 72
            Pseudo Genes (internal stop)      :: 29 of 72
            Pseudo Genes (multiple problems)  :: 25 of 72
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:47:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 625899
            Orig. end                         :: 648398
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023477.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Jacqueline Abranches.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22499
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RaS-RiPP"
                     /product="RRE-containing"
                     /region_number="3"
                     /rules="(PF04055 and TIGR01716)"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..22499
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="interleaved"
                     /product="RaS-RiPP"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22179
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12179](+)"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12179
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     misc_feature    64..73
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.78"
                     /tool="antismash"
     gene            153..956
                     /locus_tag="CO204_RS03365"
                     /old_locus_tag="CO204_03355"
     CDS             153..956
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019804161.1"
                     /locus_tag="CO204_RS03365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03355"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_002262928.1"
                     /transl_table=11
                     /translation="MTETGFRYSILASGSSGNSFYLETPQKRILIDAGLSGKKISQLMA
                     EIDRKVDDVDAILVTHEHKDHIHGVGVLARKYGLDVYANAATWQAMDGMIGKIDVSQKH
                     IFDLGKTITFGDIDIESFGVSHDAAQPQFYRLMKDGKSFVILTDTGYVSDRMADLIENA
                     DGYLIESNHDIEILRSGIYPWSLKQRILSDKGHLSNDDGAETMVRTLGNKTKKIYLGHL
                     SKENNVKELAHMTMKNALMQADLAVDHDFKIYDTSPDTALPLAKI"
     misc_feature    complement(162..180)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.33"
                     /tool="antismash"
     gene            1063..1758
                     /gene="rnc"
                     /locus_tag="CO204_RS03370"
                     /old_locus_tag="CO204_03360"
     CDS             1063..1758
                     /EC_number="3.1.26.3"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004525 - ribonuclease III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006364 - rRNA processing [Evidence IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="rnc"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019322985.1"
                     /locus_tag="CO204_RS03370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03360"
                     /product="ribonuclease III"
                     /protein_id="WP_002266141.1"
                     /transl_table=11
                     /translation="MKTLEKKLAEDFKIVFSDKELLETAFTHTSYANEHRLLNISHNER
                     LEFLGDAVLQLTISRYLFDKYPQKAEGDLSKMRSMIVREESLAGFSRNCHFDRYIKLGK
                     GEEKSGGRQRDTILGDLFEAFLGALLLDAGLKAVEAFLNQVVIPKVENNNYERVTDYKT
                     ALQELLQVDGDVLIDYEVLKESGPAHAKCFEVAVSMNHEKLSSGTGKSKKLAEQEAAKN
                     ALEKLQRGS"
     gene            1758..5294
                     /gene="smc"
                     /locus_tag="CO204_RS03375"
                     /old_locus_tag="CO204_03365"
     CDS             1758..5294
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="smc"
                     /gene_functions="other (smcogs) SMCOG1218: Exonuclease"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002266942.1"
                     /locus_tag="CO204_RS03375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03365"
                     /product="chromosome segregation protein SMC"
                     /protein_id="WP_019313341.1"
                     /transl_table=11
                     /translation="MFLKEIEMQGFKSFADKTKVEFDRGVTAVVGPNGSGKSNITESLR
                     WALGESSAKSLRGGKMPDVIFAGTENRKPLNYAQVTVILDNSDAFIKDAQEEIRIERHI
                     YRNGDSDYLIDGKKVRLRDIHDLFMDTGLGRDSFSIISQGRVEEIFNSKPEERRSIFEE
                     AAGVLKYKTRKKETQSKLTQTQDNLDRLDDIIYELETQIKPLERQAKTAKEFLVLETER
                     KEKQLDLLVYQILHHKEALVKNQAELEKVKQNLAAYYQERDLLETKNQTLKEKRHQLSR
                     QMDQKQADLLEMTRLISDYERQIERIHLEVSQKTEKKQSTQKSLEQLSEQKASLKAELA
                     QKEVDLEQLEEDLKQKNQEIKNVETELSRFATDPDHIIESLREDFVRLMQKEADTSNQL
                     AVLKAEMDSRKQESESKTAEIKQVQADLEKAKDREQRESANFETAKTKVQELLKDYQKT
                     AQLVQNLEAAYAEQQEAMFQLLDDVKDKKARQSSLKSILKSHSNFYAGVRSVLQQADKI
                     KGIVGAVSEHLTFDKKYQTALEIALGASSQNIIVEDEAAAKRSIDFLKKNRQGRATFLP
                     LTTIKPRRLSESNQSLLTSSQGFLGLARDLVSFEPRLQTIFGNLLGVTAIFDTVGHANQ
                     AARQLRYQVRLVTLDGTEIRPGGSFSGGTSRQNNTTFIKPELDHLTQELALLEEKQVEQ
                     ERTVEKTKQDLEVKKADLLELREKGNQARLAEQKAEMEYQQSESHLQELVLLYTQLKQT
                     NQADLNRDLEKDQALLQEKLYKIADDKEKLNQEIAQIKEDKDSIQQKTAALSQQLSSLQ
                     LSERDLSNTQKFERTNLKRLAEELAELEQNEVGMMQLLDSQEEDLDEKRLPSLKQQLAN
                     AQARKIESDQELVRYRFELEDCEAQLEEVETNLLKTNQKNEEFIRQQTQLEAKGDHLSN
                     QLRRFANNLAEDYQLSLDDAKQKAGPIENLEAAQAHLSQLEKQIKGLGPVNLDAIGQYD
                     EVSERLHFLNSQKDDLVHAKELLLNTIHDMDDEVKARFKTTFEAIRDSFKTTFTQMFGG
                     GSADLLLTEGDLLMTGVEISVQPPGKKIQSLNLMSGGEKALSALALLFAIIRVKTIPFV
                     ILDEVEAALDEANVKRFGDYLNRFDKSSQFIVVTHRKGTMSAADSIYGVTMQESGVSKI
                     ISVKLKEVEKIS"
     protocluster    2176..22499
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[12175:12499](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12176..12499
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="2"
     gene            5734..6777
                     /gene="pheS"
                     /locus_tag="CO204_RS03380"
                     /old_locus_tag="CO204_03370"
     CDS             5734..6777
                     /EC_number="6.1.1.20"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pheS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019314825.1"
                     /locus_tag="CO204_RS03380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03370"
                     /product="phenylalanine--tRNA ligase subunit alpha"
                     /protein_id="WP_002268116.1"
                     /transl_table=11
                     /translation="MDLQAQLEELRKSTQATLKEMSGNHSKELQDLRVKVLGKKGSLTE
                     LLKGLKDLPNELRPVVGKQVNEVRDVLTKAFEEQAKIVEAAKIQAQLESETLDVTLPGR
                     QIHLGNRHVLSQISEEIEDIFLGMGFQVVDGYEVEQDYYNFERMNLPKDHPARDMQDTF
                     YISEDILLRTHTSPVQARTLDKHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLV
                     VGKNISMGDLKGTLEMISKKMFGEDRKIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVC
                     KKTGWIEILGAGMVHPSVLEMSGVDSEEYSGFAFGLGQERMAMLRYGINDIRGFYQGDS
                     RFTEQFS"
     misc_feature    complement(6844..6856)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     gene            6850..7371
                     /locus_tag="CO204_RS03385"
                     /old_locus_tag="CO204_03375"
     CDS             6850..7371
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019317018.1"
                     /locus_tag="CO204_RS03385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03375"
                     /product="N-acetyltransferase"
                     /protein_id="WP_019313340.1"
                     /transl_table=11
                     /translation="MSQVEIRKVNQDELSLLQKIAIQTFHETFAFDNTAEQLQNFFDEA
                     YTLSALKLELADKESETYFILMSGKAAGFLKVNWGSSQTEQVLEDAFEIQRLYILKAYQ
                     GLGLGKQLFEFALERAQISGLSWVWLGVWEKNVKAQLLYAKYGFEQFSKHSFFVGNKVD
                     TDWLLKKSLS"
     gene            7385..9790
                     /gene="pheT"
                     /locus_tag="CO204_RS03390"
                     /old_locus_tag="CO204_03380"
     CDS             7385..9790
                     /EC_number="6.1.1.20"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006432 - phenylalanyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pheT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002311998.1"
                     /locus_tag="CO204_RS03390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03380"
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /protein_id="WP_106006701.1"
                     /transl_table=11
                     /translation="MLVSYKWLKELVDIDVPSHELAEKMSTTGIEVEGVDVPAEGLSKL
                     VVGHVLSCEDVPETHLHLCQVDTGEEESRQIVCGAPNITAGIKVIVALPGARIADNYKI
                     KKGKIRGMESLGMICSLQELGLPDSIIPKEYSDGIQILPEDAVPGESIFPYLDLDDEII
                     ELSITPNRADALSMRGVAHEVAAIYDKTVHFEDKVLTESDKKAADLIKVAIASDKVLTY
                     KARVVENVTIKPSPQWLQNLLMNAGIRPINNVVDVTNYVLLYFGQPMHAFDLDKFEGKD
                     ILARQAKAGEKLVTLDGEARDLIEEDLVITVADKPVALAGVMGGAATGIDASSKNVVLE
                     AAVFDGKSVRKTSSRLNLRSESSSRFEKGVNYADVVKALDFAAAMLTELADGTVLAGQV
                     SAGAVPTDDIQVSTSLDYVNVRLGTDLVFSDIESVFARLGFGLSGNDEKFTVSVPRRRW
                     DISIQADLVEEIARIYGYDKLPTTLPEAAGTVGELTKSQKLRRKIRSLAEGSGLSEIIS
                     YALTTPEKAVAFTPNPSKVTELMWPMTVERSALRQNIVSGMLDTIAYNVARKSNNLALY
                     EIGKVFEQTADPKKDLPKEIDTFAFALTGLVTEKDFQTPATPVDFFYAKGVLEAILAKL
                     EITVQFVATKEMANMHPGRTALIERDGQVIGYLGQVHPQTAKLYDIPETYVAELNLNAL
                     EAALKSDLVFEDITKFPAVSRDIALLLSEKVSHQDILDAIAASGVKRLTKVKLFDVYAG
                     EKLGQGKKSMAYSLTFQNPNDNLTDEEVAKYMEKITSALTEKVGAEVR"
     gene            10001..10858
                     /locus_tag="CO204_RS03395"
                     /old_locus_tag="CO204_03385"
     CDS             10001..10858
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019804849.1"
                     /locus_tag="CO204_RS03395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03385"
                     /product="Rgg/GadR/MutR family transcriptional regulator"
                     /protein_id="WP_002267478.1"
                     /sec_met_domain="TIGR01716 (E-value: 3e-48, bitscore:
                     161.2, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEYGKIFKKFRESRGLKMKEVAGSNLSTSHLSRFENGESELTIS
                     KLMTALYEINMPIEEFMYAANDFHQDELNELLKDVRECVNNKDVERLKAVLIKQQENLK
                     EGRIFHHLNVILVKIRLQDLSGETYYSKADLDYLTNYLFKVEYWGFYELLLFTNTIDVF
                     KHETFMVLSREMMRRSDFYKEIPRNRRLISRMALNSFITCIERDKLIDALYFEKQLSIC
                     HFDETEIYERLVFHYAQNLFAYKKYKTTFAIIEMKKSVAAMKLAGSLHIAETYENHLQK
                     ILEG"
     misc_feature    complement(10906..10919)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 26.23"
                     /tool="antismash"
     gene            11064..12179
                     /locus_tag="CO204_RS03400"
                     /old_locus_tag="CO204_03390"
     CDS             11064..12179
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002265228.1"
                     /locus_tag="CO204_RS03400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03390"
                     /product="radical SAM protein"
                     /protein_id="WP_019313337.1"
                     /sec_met_domain="PF04055 (E-value: 7.7e-22, bitscore: 75.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 5.2e-47, bitscore:
                     157.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5e-11, bitscore: 40.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 1.2e-08, bitscore: 31.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 9.4e-13, bitscore:
                     45.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.5e-11, bitscore: 40.4,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDYSPYPLLVDVCVTNRCNLSCSYCSAEAGPFASKKGEMSVEKL
                     DSIFRELNLMGVPRVGVTGGEPFIRDDILDILKAFDKYHFAKVLNTNGNLITDSVAKEL
                     SKLHLDRICVTVDGSCSKVHDSQRGKGSFKKAIEGIKNLQRYNLPVSTLFTLGRHNVDD
                     LINTIRLNDMLRIKYMSVMIICPTGRANDGSILADKKHWYPVFLDLTERLSRGEFKVKF
                     KIVPPNESDVFWTHYFPLAFYNRLDLLESVWHQSLNFNSNKKREISCQAGVRACSINHK
                     GDVYGCDLMNGIDELVAGNVKEKSFYEIWHNSPIFHKLRNITFNDISGKCADCPLPWCG
                     GGCRCSALELDGTLLGSDLACFYDEEESVLV"
     gene            12176..12499
                     /locus_tag="CO204_RS03405"
                     /old_locus_tag="CO204_03395"
     CDS             12176..12499
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002265227.1"
                     /locus_tag="CO204_RS03405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03395"
                     /product="PqqD family protein"
                     /protein_id="WP_002281716.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4.2e-09,
                     bitscore: 33.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Streptide_RRE (E-value: 6.8e-39, bitscore:
                     129.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.8e-07, bitscore: 28.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNHFTIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYC
                     ISKNFSLNKIIEVIQEEYDVTYDDCKKAIVHFLEETPILHIIYANLIKSDIYLYLKPFR
                     EAL"
     aSDomain        12191..12412
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CO204_RS03405_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.90E-11"
                     /identifier="RREFam002.1"
                     /label="CO204_RS03405"
                     /locus_tag="CO204_RS03405"
                     /protein_end="79"
                     /protein_start="5"
                     /score="33.2"
                     /tool="antismash"
                     /translation="TIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYCISKNF
                     SLNKIIEVIQEEYDVTYDDCKKAIVHFLE"
     aSDomain        12191..12490
                     /aSDomain="Streptide_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM enzyme in a
                     streptide-like cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CO204_RS03405_Streptide_RRE.1"
                     /evalue="9.60E-41"
                     /identifier="RREFam022.1"
                     /label="CO204_RS03405"
                     /locus_tag="CO204_RS03405"
                     /protein_end="105"
                     /protein_start="5"
                     /score="129.2"
                     /tool="antismash"
                     /translation="TIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYCISKNF
                     SLNKIIEVIQEEYDVTYDDCKKAIVHFLEETPILHIIYANLIKSDIYLYLKPFRE"
     gene            12496..13776
                     /locus_tag="CO204_RS03410"
                     /old_locus_tag="CO204_03400"
     CDS             12496..13776
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803472.1"
                     /locus_tag="CO204_RS03410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03400"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_002265226.1"
                     /transl_table=11
                     /translation="MSYSKEVNRYVFPLVATNLVQVLIGQISLHFAVDNSNAALSGISV
                     IQNFLFAFGGILGAFSLSFNIRGAKAFYNKEYQRFKNLLKSSLLIDIGIGLSFILFCLG
                     LSRPFLKVFYGFDGQLLELSTTYFKIMSPYILLTLLIFLFSNLLKIEKKTKPIFWIGTL
                     SSVLDVLLNYYLVPLLGIRGAAISSILSLLVIVLGYFIFVKSLVFQALQEASTSKLELI
                     RFGIPLSIQEILESVLFIMAFDAFMGRQGLRILSIYAVVSQLFAIVRTPAFMYAGSIAI
                     FLPEARKKEDEKALIATIFRNSYAVIFIFACLVTVFSNPFAHFLSDEVIDNVLPFTLYT
                     VVVMGATPLYESSKMLLQSNDDEQWVLKITSIVNILSILILLVLQLMGKQTYQSLYGIY
                     GLSLIVLSILFIKRNSEKRVSSRKMTM"
     misc_feature    complement(13950..13965)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            <14091..14261
                     /locus_tag="CO204_RS03415"
                     /old_locus_tag="CO204_03405"
                     /pseudo=""
     CDS             <14091..14261
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002998015.1"
                     /locus_tag="CO204_RS03415"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03405"
                     /product="phenylalanine--tRNA ligase subunit beta"
                     /pseudo=""
                     /transl_table=11
                     /translation="KLFDVYAGEKLGQGKKSMAYSLTFQNPNDNLTDEEVAKYMEKITK
                     ALTEKIGAEVR"
     gene            14625..14951
                     /locus_tag="CO204_RS03420"
                     /old_locus_tag="CO204_03410"
     CDS             14625..14951
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803471.1"
                     /locus_tag="CO204_RS03420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03410"
                     /product="hypothetical protein"
                     /protein_id="WP_002262922.1"
                     /transl_table=11
                     /translation="MTHVVSEIFKDGPVDRFGLRGDPVFWNYLEKHFQKVAMPYSERKL
                     EEDIRTIYQDLTGKEFRMGEMALVKDFISESGGMSSGWLSDDFWLKSAIPLLKKRLAKW
                     NETL"
     gene            15126..15371
                     /locus_tag="CO204_RS03425"
                     /old_locus_tag="CO204_03415"
     CDS             15126..15371
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004261618.1"
                     /locus_tag="CO204_RS03425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03415"
                     /product="SemiSWEET family transporter"
                     /protein_id="WP_002262921.1"
                     /transl_table=11
                     /translation="MLILGWVATFMSIMMYVSYIPQIMNNLAGNKGDFIQPSVAALNCT
                     LWVIYGLCKEKRDLPLAAANMPGIVFGLIAAITALV"
     misc_feature    16140..16153
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.82"
                     /tool="antismash"
     gene            16239..19481
                     /gene="rexB"
                     /locus_tag="CO204_RS03430"
                     /old_locus_tag="CO204_03420"
     CDS             16239..19481
                     /GO_function="GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0000724 - double-strand break repair via
                     homologous recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="rexB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012997660.1"
                     /locus_tag="CO204_RS03430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_03420"
                     /product="ATP-dependent nuclease subunit B"
                     /protein_id="WP_106006702.1"
                     /transl_table=11
                     /translation="MKLLYTDIPYNITEILAEEAQIAAKAGKRVFYIAPNSLSFEKERA
                     VLETLPERASFAITITRFEQMARYFVLNDIHQGETIDDNGLAMVFYRALSSFSDQDLRV
                     FGRLKQDAHFINQLVDLYKELKASNLTVLELNQLNSAEKQEDLIKIFTEVETILSAGHF
                     DNQSKIAFFAQQIKFGHLDTALQDLTIVIDGFTRFSAEEENLIGLLYEKGVDIIIGTYI
                     SQKAYRSTFSNGNVYQASLDFIRGLAGKFQTKPEYVVSKQEALPAFTKLSQLFESRHDF
                     SDSQLVLTDKDKEHVTIWDVINQKEEVEHVAKSIRRKLYEGHRYKDILVLLGDVDAYKL
                     QIGKIFDKYEIPYYFGKAESMSSHPLVHFVDSLERVKRYNFRAEDVMNLLKSGLYGKIR
                     QNQLDKLEQYVTYADIKGKTKFFKDFTLDNHGQFDLKALNKLRAEVMSPLQELVKIQAQ
                     KGDSILQKLTNFLEAISLTNNFSKLIQGVSDTEQEKNEQVWKTFTVILEQFHTIFGQEK
                     MKLADFLALLRSGMLAADYRTVPASVDVVTVKSYDLVEPHSNKFVFALGMTQSHFPKIV
                     QNKSLISDEERAKINEATPDNRRFVIVTKENLKKNHFTALSLFNAATQELVLTLPQILN
                     EAEDNTSSYLLELQDMGVPVVEKGRNRLAADPEDISNYKALLSRVIELNRSAIDQELSK
                     EEQTFWSVAVRYLRQKLAKEGLTIPEVNDKMQTKQVAAEVMAARFPIDQPLNLSSSALT
                     TFYNNQYLYFLQYILGLQELETIHPDARNHGTYLHRVFELVMQDQSTDDFDSKLNRAID
                     ITNHEDSFHLVYNEDEESRYALGILEDIARSTATILKGDNPVQAESEEEAFELMLDQAV
                     KIRGVIDRIDRLSDGSLGIVDYKSSKNTFDLQKFYNGLSPQLVTYIEALRSCKNLNETD
                     KIFGAMYLHMQEPKTDLANMKSIEKIPEIVHKNLSYKGLFLEDEKAHLANGKYHLHDAV
                     YSQKEVDLLLDYNKRLYRSAAKQIRKGNFLINPYSQDGKSVQGEQLKAITHFEADRHMP
                     YARKLYQLPRKEKRQGFLALMQSKKEEEGNDL"
     misc_feature    complement(20390..20400)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    22290..22304
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.01"
                     /tool="antismash"
     misc_feature    22482..22497
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.01"
                     /tool="antismash"
ORIGIN
        1 ggattagcaa tcgccaaaga aattgtcaaa cagcataaag gctttatttg ggccaatagt
       61 gaggaaggcg aagggtcgac ctttaccatc gttttacctt atgaaaacga taatgatgca
      121 attgatgaat gggaagaaga tgaagacgaa tcatgacaga aacaggtttt agatacagca
      181 ttctggcttc tggttcaagt ggcaatagtt tttatttgga aactcctcaa aagagaattt
      241 taattgacgc aggcctctca ggtaagaaaa ttagtcaatt aatggcagaa atagaccgaa
      301 aagtagatga tgttgatgcc attttagtaa cacatgaaca taaagatcat attcacggtg
      361 ttggtgtact agctcggaaa tatggtttgg atgtctatgc gaatgcagca acatggcaag
      421 ctatggatgg catgattggt aaaattgatg tcagccaaaa acatatcttt gatctgggga
      481 aaaccatcac ttttggggat attgatattg aaagttttgg tgtcagccat gatgctgctc
      541 aaccacagtt ttaccgcctg atgaaagacg gcaagagttt tgtcatattg acggatacag
      601 gttatgtcag tgatcgtatg gcagatctga ttgaaaatgc tgatggttat ctgattgagt
      661 ccaatcatga tattgaaatt ttacgctcag gtatctaccc ttggagttta aaacagcgta
      721 ttttatccga taaaggacac ctatcaaatg atgatggtgc agaaacaatg gttcgaactt
      781 tggggaataa aacaaaaaag atttatttgg gacatctcag caaagaaaac aatgtcaaag
      841 aattagccca tatgacgatg aagaatgctc tcatgcaggc agatttggct gtagatcatg
      901 attttaaaat ttatgatacc tcgccagata ctgctttacc attagcaaaa atctagtgga
      961 cagcttaaaa ggaagaatga aaaacaaaga ttactcggaa atggttgttc tgggtgattt
     1021 ttgctataat agaaaggtct aaggataaaa gaaaggattt atatgaaaac attagaaaaa
     1081 aaactggcag aagactttaa gatcgtcttt tctgacaagg aattattgga aactgccttt
     1141 actcatacta gttatgctaa tgagcatcgc ctcctaaaca tttcacataa cgagcgcttg
     1201 gaatttttag gagacgctgt tctgcagtta acgatttcac gttatctttt tgacaaatac
     1261 cctcaaaaag ctgaaggtga tttatcaaaa atgcgttcga tgattgttcg tgaagaaagt
     1321 ttggcgggtt tttctagaaa ttgtcacttt gaccgctata ttaaattagg taagggtgaa
     1381 gaaaaatctg gcggtcgtca aagagatact attttgggcg atttatttga agctttttta
     1441 ggtgctcttt tattggatgc aggtcttaaa gctgttgagg cctttctcaa tcaagttgtg
     1501 attcctaagg ttgaaaataa taattatgaa cgtgtgaccg attataaaac ggcacttcaa
     1561 gaattattgc aagttgacgg ggatgttttg atcgattacg aggtcttaaa agaatcagga
     1621 cccgcccatg caaaatgctt tgaagttgct gtttctatga atcatgaaaa acttagtagc
     1681 gggacaggca aatcaaaaaa attagcagag caagaggctg ctaaaaatgc gcttgaaaaa
     1741 cttcaacgag gttcttaatg tttttaaaag aaattgaaat gcagggattt aaatcttttg
     1801 ctgataagac taaggttgag ttcgacagag gagtgacagc cgttgttgga ccaaatggtt
     1861 caggaaagag taatattacg gagagtttac gctgggcttt gggtgagtca agtgccaaga
     1921 gcctgcgtgg cggcaagatg ccagacgtga tttttgcagg aactgaaaat cgaaagccac
     1981 tcaattacgc tcaagtaacg gttattttag ataatagcga tgcttttatc aaagacgctc
     2041 aagaggagat tcgcattgaa cgccatattt atcgtaatgg ggacagcgat tatcttattg
     2101 atggtaaaaa agtacgcctg cgcgatattc acgatttgtt tatggatact ggtttggggc
     2161 gtgattcctt ttccattatt tctcaaggac gtgtggaaga gatttttaat agtaaaccag
     2221 aagagcgtcg ttcaattttt gaagaagcag ccggtgtctt aaaatacaaa acacgtaaaa
     2281 aagagacgca gtctaagcta acacagactc aggataattt ggatcggctg gatgatatta
     2341 tctatgaact ggagacacag ataaagcctt tagaacgtca ggcaaaaaca gccaaagaat
     2401 ttctggtttt ggaaacagag cgcaaggaga aacagttaga cttgctggtc taccaaattc
     2461 tccatcataa ggaagcctta gtgaaaaacc aagctgagct tgaaaaagtt aaacaaaatt
     2521 tagcagccta ttatcaagaa cgtgatctat tagaaactaa gaatcagact ctaaaagaaa
     2581 aaaggcacca gctttctcgt caaatggatc aaaagcaggc tgatctcctt gaaatgacac
     2641 gtctcattag tgattatgag cgtcagattg aacgcattca tttagaggtt agtcaaaaga
     2701 cagaaaagaa gcaatctact caaaaaagcc tagaacaatt gtcagagcaa aaggcttctc
     2761 ttaaagcaga attagctcaa aaagaagttg acttagaaca attagaagag gatctcaaac
     2821 aaaaaaatca agaaattaaa aatgtcgaaa cggaattgtc acgttttgca acagatcctg
     2881 atcatattat tgaaagttta cgagaagatt ttgttagact catgcaaaaa gaggctgata
     2941 cttctaacca attggctgtt ttaaaagcag aaatggatag tcgaaagcaa gaatccgaaa
     3001 gtaaaacagc agaaattaaa caagtacaag cagacttaga gaaagcaaaa gatcgagaac
     3061 aaagggaatc cgcaaacttt gaaactgcta aaaccaaagt tcaagaattg ctaaaggact
     3121 atcaaaaaac agcacagctt gttcagaatt tagaagctgc ttatgctgag cagcaagagg
     3181 ctatgtttca attgttggat gatgtcaaag acaagaaagc acgccaaagc agtctgaagt
     3241 ccatcttaaa aagccatagt aatttctatg caggtgttag gtctgttctt cagcaggctg
     3301 ataaaattaa aggtattgtt ggcgcggtta gtgaacattt aacttttgat aaaaaatatc
     3361 aaaccgcact tgagattgcc ttaggtgcca gcagtcaaaa tattattgtt gaagatgaag
     3421 cggcggccaa acgatctatt gattttttaa agaagaaccg tcaaggtcga gcaacttttc
     3481 ttcctttaac aaccattaaa ccccgtcgtt tatctgagtc aaatcaaagc ctattaactt
     3541 ccagccaggg ctttctcggt ttagcacgtg atttggtaag ttttgagcct cgtttgcaaa
     3601 caatttttgg caatttactg ggtgtcacag cgatttttga tacggttggt catgccaatc
     3661 aggcagctcg ccagttacgt tatcaagtgc gtcttgtgac attagatgga acagagatcc
     3721 gtcccggagg gtccttttca ggagggacta gccgtcaaaa taatacaact tttatcaagc
     3781 cagaactgga tcatttgaca caagagctag cgcttttaga agaaaaacaa gttgagcagg
     3841 aaagaacagt tgaaaagacc aagcaggact tggaagtgaa aaaagcagat cttttagaat
     3901 taagggaaaa aggaaatcaa gcccgattgg ctgagcaaaa ggctgagatg gagtatcaac
     3961 aatcagagtc tcatttacaa gagctggtct tgctttatac ccaattaaaa caaacaaatc
     4021 aggcggatct taatcgagac ttagaaaaag accaagcact tttacaagaa aagctgtata
     4081 aaattgctga tgacaaggaa aagctcaatc aagagattgc tcaaatcaag gaagataagg
     4141 atagtattca gcaaaagaca gctgctttaa gtcaacaact ctcttctttg caactttctg
     4201 agcgtgattt gtctaataca cagaaatttg aaagaacgaa tttaaaacgt ttggcagaag
     4261 aattagctga attggagcaa aatgaagttg gtatgatgca acttttagat agccaagaag
     4321 aggatttgga tgaaaaacgt ttaccatcgc tcaaacagca attagcaaac gctcaggcta
     4381 gaaaaataga gagtgaccaa gaacttgtcc gctaccgttt tgaactggaa gactgtgaag
     4441 cacagctaga agaggttgag accaatctcc taaaaactaa tcaaaagaat gaagagttca
     4501 ttcgtcagca aacgcaatta gaagcaaaag gggatcattt atccaatcaa ttgcgccgtt
     4561 ttgccaataa cttggctgaa gattatcaac taagcttaga tgatgctaaa caaaaggcag
     4621 gaccgattga aaatctagaa gctgctcaag ctcatttaag ccaattggaa aagcaaatta
     4681 agggattggg accggtcaac cttgacgcaa tcggtcagta cgatgaagtg tctgagcgtt
     4741 tgcatttctt aaatagtcaa aaagatgacc ttgttcacgc taaggaactt ctcctgaata
     4801 ctattcatga tatggatgat gaggtcaagg cacgctttaa gacgactttt gaagctattc
     4861 gtgacagttt taagacgacc tttacgcaga tgtttggcgg aggaagtgct gacttgcttt
     4921 tgacagaagg agatctcttg atgaccggtg ttgaaatttc agtgcagccg cccggcaaaa
     4981 agattcaatc tctcaatctt atgtctggtg gtgaaaaggc actgtctgct ttggcattgt
     5041 tatttgccat tattcgtgtt aaaaccattc cctttgttat tttggatgag gttgaggctg
     5101 ctcttgacga ggccaatgtc aagcgttttg gtgattatct gaatcgtttt gataagtcca
     5161 gccagtttat tgtggtcact caccgtaaag gcaccatgtc tgctgcagat agtatatatg
     5221 gggttaccat gcaggaatca ggtgtctcta agattatctc tgttaagcta aaagaagtcg
     5281 aaaagatatc ttaaaaaggc ttggaagtgc ttagtttgaa aaaactgtaa ggacacaatc
     5341 aatctttgac ggcaatagta cttaaagtga ctctcaacaa ggaaacaagg cggtaacgac
     5401 aaaatcattt ctgtaaattg caatggaatc tcgttctcca tagaatcttt tattcagcct
     5461 attgagaaat tttgtgaaat ctgttaaaat agtaacaatt gaataaaagt ctatgagatt
     5521 agtagcttta tggaagtttg acagggaatg cggggcgtga ctggaaaccc gctggatgaa
     5581 agtttagtga attcactcag aaagaaaggc ttaataatta aggtctagtc atactagata
     5641 aaaacggatg gtaccgcgtg tcaacgctcc gcttaaggag ttttggcacg ttttttgttt
     5701 ttaacaaggt ccttaaatag gaaaggaaat cacatggatt tacaagcaca attagaagag
     5761 ctgagaaaat caactcaagc aacattaaag gaaatgagcg gcaatcacag caaagaatta
     5821 caagatttgc gtgttaaggt tttgggtaag aaaggttcct tgacagaact tttaaaaggt
     5881 ctaaaggact taccaaatga gttgcgtcct gttgttggaa aacaagtcaa tgaagtccgt
     5941 gatgtcttaa caaaggcttt tgaagaacaa gctaaaatcg ttgaagccgc caaaattcaa
     6001 gcgcaattag aatcagaaac attagatgtc actcttccgg gacgccaaat acatttaggc
     6061 aatcgccatg ttctcagtca gataagtgaa gaaattgaag atatattctt aggaatgggt
     6121 tttcaagtgg ttgatggcta tgaagttgaa caagactatt acaatttcga acgcatgaat
     6181 ttgcccaaag atcacccagc acgtgatatg caggacacgt tttatatttc tgaagacatt
     6241 ttgcttcgaa cacataccag tcctgtgcag gcacgtactt tagataaaca tgatttttct
     6301 aaagggccgc ttaagatgat ttcacccgga cgcgtttttc gccgcgatac agatgatgcg
     6361 acgcattccc atcaattcca tcaaattgaa ggcttggtcg ttggtaaaaa catttctatg
     6421 ggtgacctca aaggaacact ggaaatgatt agtaaaaaaa tgtttggtga agatcgtaag
     6481 attcgtctgc gtccttctta tttcccattt acagagcctt ctgttgaagt ggatgtttcg
     6541 tgttttaaat gcggcggcaa aggctgtaat gtttgtaaga aaacaggttg gattgaaatt
     6601 cttggtgccg gtatggttca tccaagtgtt cttgagatgt ccggcgttga ctctgaagaa
     6661 tattctggtt ttgcctttgg cttaggccaa gaacgtatgg ctatgctgcg ctatggaatc
     6721 aatgatattc gaggtttcta ccaaggtgac agccgtttta cagaacagtt cagttaaatc
     6781 tataaggttg tagagctttt tgcaagctaa ttgctctggc tcagccatcc acaagttaaa
     6841 ggagtgaaaa tgtcacaggt tgaaattaga aaagtcaatc aagatgagct ttctttgctt
     6901 cagaaaattg ctattcagac ttttcatgaa acttttgctt ttgataatac agcagagcag
     6961 ctgcaaaact tttttgacga agcttatact ttgtctgctt taaaattaga attagctgat
     7021 aaagaatcag aaacctattt tattttgatg tccggtaaag cagcgggatt tttgaaagtg
     7081 aactggggca gctctcaaac cgagcaggta ctagaagatg catttgaaat tcaacgtctt
     7141 tatattttaa aagcctatca aggtttaggt ttaggaaaac agctttttga atttgcttta
     7201 gaacgtgcgc aaatatcagg cttatcatgg gtttggctgg gcgtttggga aaagaatgtt
     7261 aaggcccagt tattgtatgc taaatatgga tttgaacaat tttctaagca ttcttttttt
     7321 gttggtaaca aagtggatac ggattggttg cttaaaaagt ctttaagtta gggaaaggaa
     7381 atacatgtta gtaagttata aatggttgaa agaattagtt gatattgatg tacctagtca
     7441 cgaattggct gaaaaaatgt caacaacagg tattgaagtt gaaggggtag acgttccagc
     7501 agaaggactg tcaaaattag tcgtcggtca tgtcctttct tgtgaagatg ttccagaaac
     7561 gcatcttcat ctttgtcagg tggatactgg cgaggaagaa tctcgtcaaa tcgtttgtgg
     7621 agcaccaaat attacagctg gcattaaagt aattgttgct cttccgggag ctcgtattgc
     7681 agataattat aagattaaaa aagggaaaat ccgcggtatg gaatctctgg gtatgatttg
     7741 ctctctgcag gagcttggtt tgccggacag cattattcct aaggagtatt cagatggcat
     7801 tcaaattttg cctgaagatg ctgtgccggg tgaaagtatc ttcccttatt tggacttaga
     7861 tgatgaaatc attgagctgt ctatcacacc taaccgtgca gatgctttat ccatgcgcgg
     7921 tgtggctcat gaagtagcag cgatttatga taaaactgtt cattttgaag ataaagtctt
     7981 gactgagagt gataagaaag cagctgacct tatcaaggta gccatcgctt ctgacaaggt
     8041 tttgacttac aaagcgcgtg tggttgaaaa tgtaaccatt aaaccaagtc cacagtggct
     8101 gcaaaatctg cttatgaatg ctggcattcg gcctattaat aatgtggttg atgtgaccaa
     8161 ttatgttctt ctttattttg gacagcctat gcatgctttt gatttagata agtttgaagg
     8221 caaggatatt cttgcacgtc aggcaaaagc tggtgagaaa ttagtaacac ttgatggtga
     8281 agcgcgtgat ttgattgaag aggatcttgt cattactgta gcagataaac cagtggcact
     8341 tgcaggtgtt atgggtggtg ctgcaactgg aattgatgcc tcttctaaaa atgttgtcct
     8401 tgaagcagcc gtctttgatg gaaaatcagt tcgtaaaaca agcagccgtc ttaatctgcg
     8461 ttccgaaagt tcttcacgtt ttgaaaaagg tgttaattac gctgatgttg ttaaggcact
     8521 tgattttgct gcagcaatgc tgacggaatt ggcagatgga acagttctcg ctggtcaggt
     8581 cagtgcagga gcagttccga cagatgatat tcaagtatcc actagtctgg attatgtcaa
     8641 tgttcgctta ggtacagact tagttttctc agatattgaa agtgtttttg ctcgccttgg
     8701 ttttggtctt tctggcaatg acgaaaaatt cacggtttct gtaccgcgtc gccgttggga
     8761 tattagcatt caggcggatt tggtcgaaga aatcgctcgt atttatggtt atgataaatt
     8821 accgacaaca ctgcctgaag cagcaggaac agttggtgaa ttgaccaagt cacaaaaatt
     8881 acgtcgtaag ataagaagtt tggctgaagg tagtggtctt tcagaaatta tttcctatgc
     8941 cctgacaacg cctgaaaagg cagttgcttt tacgccaaat cctagcaagg tgacagaact
     9001 gatgtggcca atgaccgttg agcgttcggc actgcgtcaa aatattgtct ctggaatgct
     9061 agataccatt gcctataatg tagcacgtaa gagcaacaat ctagccctat atgaaattgg
     9121 caaagtattt gagcaaacag cggatcccaa aaaagatttg cctaaggaaa tagatacttt
     9181 tgcctttgct ctgacaggtt tagtaactga aaaagatttc caaacaccag cgacaccagt
     9241 tgatttcttc tatgctaaag gtgttctgga agctattctt gctaaacttg aaatcactgt
     9301 tcaatttgtt gcgactaaag aaatggctaa tatgcatccc ggacgcacag ctttaattga
     9361 acgtgatggt caagttatcg gttatcttgg tcaagttcat ccgcagactg ctaaactgta
     9421 cgatattcca gaaacttatg tagcagaatt gaatcttaat gcactggaag cagctcttaa
     9481 atcggattta gtctttgaag atatcactaa attcccagct gtttcgcgcg atattgccct
     9541 gcttctttca gaaaaagtga gtcaccaaga tattttggat gctattgcag ccagcggtgt
     9601 gaaacgcctt accaaagtaa aactctttga cgtttatgct ggtgaaaaat tgggacaagg
     9661 taagaaatca atggcctaca gcctgacttt ccaaaatcct aatgataatc tcacagatga
     9721 agaagttgcc aaatacatgg aaaaaatcac ttcagcccta accgaaaaag ttggtgcaga
     9781 agtgaggtaa cgaaaaaatc taccttcaaa ggtagatttt tttggtatgt aagctagtga
     9841 gcctacccac cgccgataat gataattgtt tctaatacca ctatcaaagt cataaaaatt
     9901 ttatttctca tgtttttctc ctcactcact tttcttatat gttataataa attgcaatta
     9961 actgaatata aatcccatat agacaattga ggtactattg atgactgaat atggaaaaat
    10021 atttaaaaaa tttagagaat cacgcggtct aaaaatgaag gaagtagctg gttcaaattt
    10081 atcaacttca catctttcaa gatttgaaaa tggagaatct gagctgacaa taagtaaact
    10141 tatgacagca ctgtacgaaa taaatatgcc tattgaagaa tttatgtatg ctgccaatga
    10201 tttccatcag gatgaattaa atgagctcct taaagatgtg agggagtgtg ttaataataa
    10261 agatgttgaa cgattaaaag cggtattgat taagcaacaa gagaatttaa aagaaggtcg
    10321 aatttttcac catttgaatg ttattctagt aaaaataagg ttgcaagatt tatccggtga
    10381 aacttattat agtaaagcag acctagatta cttaacaaat tacttattta aagttgaata
    10441 ctggggtttc tatgagctgt tactttttac gaatactatt gatgttttta aacatgaaac
    10501 ttttatggtt ctctctagag agatgatgag acggtcagat ttttataaag aaatacctcg
    10561 aaatcgacgt cttatttcac gtatggctct gaattctttt ataacttgca ttgaaagaga
    10621 taaactgatt gatgcactgt attttgaaaa acaattaagc atctgtcatt ttgatgaaac
    10681 agaaatttat gaacgcttgg tctttcatta tgctcaaaat ctatttgcct ataaaaaata
    10741 taagacgaca tttgctatta ttgaaatgaa gaaatcagta gcagcaatga aattggcagg
    10801 gagtttgcat attgctgaaa cctatgaaaa ccatcttcaa aaaattttag aaggataata
    10861 tgaaattgtg tatatgggat aaaaatctct ctttttggat ttgatttata ataattctat
    10921 caaatcaagg aggtaaatac tatgttgact aaaaaagagt ttagtgttcc taaaacaact
    10981 aaggtaaact gttggggtaa gcactagtaa aacaaggtct gtaggtcatt gcatggctta
    11041 cagatttttt aggaggtatt ttaatgagag attattcacc atatccgtta ttggttgatg
    11101 tttgtgtaac aaatcgttgt aatttaagtt gttcatattg ttcagcagaa gcaggccctt
    11161 ttgccagtaa aaaaggagag atgtctgttg agaagctgga ttctattttc cgtgaattaa
    11221 atttaatggg agttccgcga gtaggtgtta ctggaggtga accgtttatt agagatgata
    11281 tattagacat cttaaaggct tttgataaat atcattttgc taaagtttta aatactaatg
    11341 gtaacctcat tacagattct gtagctaagg aattatctaa actacatttg gatagaattt
    11401 gtgtgaccgt ggatggaagt tgctctaaag ttcatgatag ccaaagaggt aaaggaagct
    11461 ttaaaaaggc aatagagggt attaaaaatt tacaaaggta taatcttcct gtttctacac
    11521 tttttacatt aggaagacac aatgtagatg atttgattaa cactattagg ttaaacgata
    11581 tgcttagaat taaatatatg tctgtaatga ttatttgccc aacaggtaga gctaatgatg
    11641 gaagcattct agcagataag aaacattggt atcctgtatt tttagattta acagagagat
    11701 tgtctcgtgg agaatttaaa gtgaagttta aaatagttcc tccaaatgaa agtgatgtct
    11761 tttggacaca ttatttccca ctagcttttt acaatcgatt agatttactt gaaagtgtat
    11821 ggcatcaaag cctgaacttt aatagtaaca agaaaagaga aatatcttgc caagctggag
    11881 taagagcttg ttctatcaac cataaaggtg atgtttatgg ttgtgatttg atgaacggca
    11941 ttgatgaact tgtagcaggt aatgtaaaag aaaaatcttt ttatgaaatt tggcataatt
    12001 ctcctatatt tcataaattg agaaatatta catttaacga tatttcgggg aaatgtgctg
    12061 attgcccctt accttggtgt ggtggtggat gtagatgcag tgcactggag ttagatggaa
    12121 ctttgcttgg atctgattta gcatgttttt atgatgaaga ggaaagcgta ttggtatgaa
    12181 aaatcatttt acaataaaag ggaagagaga ttttgttgtt gataaaattg acgatgagtt
    12241 tataggatat gatagattag atctagagta ttattctttt gatgatatag gtgctgaaat
    12301 tttatattgt atttctaaaa acttttcttt gaacaaaatc attgaggtca ttcaagaaga
    12361 gtatgatgtg acttatgacg attgtaagaa agctattgtc cattttttag aggagacacc
    12421 tatattacat attatttatg caaatcttat taaatcagac atttatttat acctaaaacc
    12481 atttcgggag gcattatgag ttattctaaa gaggtgaacc gttatgtttt tcctctcgtt
    12541 gccacaaacc ttgttcaagt tttgattggt caaatttctc ttcattttgc tgtcgataat
    12601 tctaatgctg ccttgtctgg catttctgtt atccagaatt ttctttttgc atttggaggt
    12661 attcttggag cctttagttt gtcgtttaat attagaggtg ccaaggcttt ttataataaa
    12721 gaataccaac gatttaaaaa tcttttaaaa tcatccctgc taattgatat tggaattgga
    12781 ctgtcattca ttcttttttg tctgggattg agcagacctt ttttgaaagt tttttatggt
    12841 tttgatggtc aattattgga actatcgact acctatttca agatcatgtc tccttatatt
    12901 ttattgacct tattaatctt ccttttttca aatcttttga aaattgagaa gaaaacaaag
    12961 cccatttttt ggattggaac cctaagttcc gtgctagatg tcttgttaaa ctattactta
    13021 gttcctcttt tgggaattcg tggagctgct atttcgtcta ttttatcgct gctagtcatt
    13081 gttttagggt atttcatttt tgtaaaatct cttgtttttc aagcgcttca agaggcttcg
    13141 acaagtaagt tagagcttat ccgttttgga attcctttat ccatacaaga aatactggag
    13201 agtgttttat ttatcatggc tttcgacgct ttcatgggaa gacaggggct acgcattttg
    13261 tccatctatg cggtagtcag tcaattattt gcaattgtga gaacacctgc ctttatgtat
    13321 gcgggttcaa tagcaatctt tttgcctgaa gctaggaaaa aagaagacga aaaagcattg
    13381 attgctacta tttttagaaa tagctacgct gttatattta tatttgcttg tttagtaaca
    13441 gtattttcaa atccttttgc tcattttttg tctgatgaag ttattgataa tgtgctgcct
    13501 tttactttgt acacggttgt ggtcatggga gcaacacctc tatatgaaag ctctaagatg
    13561 cttttgcaaa gcaatgatga cgaacaatgg gttttaaaaa taacaagcat tgtcaatata
    13621 ttaagtatcc ttatcttatt agttctccag ttaatgggca agcaaaccta tcaatctctg
    13681 tatggcattt atggtttgag tttaatagtg cttagtattc ttttcataaa aagaaatagt
    13741 gagaagagag tatcatcacg taaaatgaca atgtaaggct tgtagggagt aatacaagtc
    13801 ttttttagaa ctttaatgaa taaaagtttt ttgacagttt acactagttt cacctaaaaa
    13861 atattatcga tttttcaaac gaaacgtcgc agtaatcttt ggtggctaca ttaggaggtg
    13921 atctaaggcc ttgaaaatcc ctttgaagat tgacaaatca gttaatcaat cttcttctgc
    13981 ccacggcggt acctatagtt cttagtgacc ttacggtcgc tttcgataag ctaatgcttt
    14041 aggcaataag taggaaatct atgaatatgg gttcttaata tcccaaagta aaactctttg
    14101 acgtttatgc cggtgagaaa ttgggacaag gtaagaaatc aatggcctac agcctgactt
    14161 tccaaaatcc taatgataat ctcacagatg aagaagttgc caaatacatg gaaaaaatca
    14221 ccaaagccct aaccgaaaaa attggtgctg aagtgaggta aaaattgaca gctgataagc
    14281 ttatagccgt ctgtttctta tttttaaaca gataacttag taaggacagt gcccatcaat
    14341 gatgtttgct gttagttcaa tatgaaaaga aaattaattt ctgtaaacgt cgtttgtcaa
    14401 gcctataaaa gacctgtgtt tgtgaaaaca atttcccatt ttaaagggat gatagtcatt
    14461 tagtttatcc tttataattt tgttagcgca tcttaccata cgtttttgtg actaactttg
    14521 tcagtttaat tatcaccctt caaccctccc agttgttaaa actgtctgtg gcttgctgcc
    14581 ttgtcttaca atcaaaccaa aagactagaa taaggagaaa ggttatgaca catgttgtat
    14641 ctgaaatttt taaagatggc ccggtagaca ggtttggttt acgaggggat cctgtttttt
    14701 ggaactattt agaaaagcat tttcaaaagg tagctatgcc atattccgaa agaaaattag
    14761 aagaggatat aagaacgatc tatcaagact taactggaaa agaatttaga atgggtgaga
    14821 tggctcttgt taaagacttt ataagtgaat ccggcggcat gtcatcagga tggcttagtg
    14881 atgatttttg gcttaaatca gctataccgc ttctgaaaaa acgattggca aaatggaatg
    14941 aaactttata aagactgtaa tttattgatt atgaagaatg ataaatcaag caatggtgtc
    15001 ataaaagtca aacgggatgg cttatcattc ttttgaaaac aatttgacat tttcaaagaa
    15061 aagtttaaaa tggaaaacag tctgaagaaa tgaggtaatg aagaactttg cggaaagaaa
    15121 aaaatatgtt gatattaggt tgggtagcga cttttatgtc tataatgatg tatgtgtctt
    15181 atatccctca gatcatgaat aatttagcag gaaataaggg ggattttatc caaccgtcag
    15241 tagctgcact taactgcaca ctgtgggtaa tttatggtct ttgtaaagaa aagcgagacc
    15301 ttcctttagc tgccgccaat atgccaggca ttgtttttgg cttgattgca gcgattacgg
    15361 cattagttta gctttataaa agcatttatt tcataaaggt tgtgaattga gtctgtgaaa
    15421 tagagatttc tgtggaacgg ctcttttttt ctgtcattta tcaacctttt cctgagatga
    15481 tacctactta atcacaatca aatagacgag gaaatgtgcc aaagttaatg agggctaagc
    15541 aagaaaagct gttagcgacg gtctgtctag ccaccttgct agctttcttt ctcagtgtta
    15601 ttgattgctc gaacgtgtat cgcaaggttt caagaaagtt cactgacgct ggattttcta
    15661 cgaattttgg ataaaagtgt tctaactttt tattgtgtag tggttttagt ttaacgcagt
    15721 gataaattgg aattttcgcg tcttgttttt taggctcaac cctttaaagt tcggtgttct
    15781 gccggagctt atctaatcta ttttaaggaa agcaagacga caaattgaat cgagctttca
    15841 ttacgattgg ccgaactttt tatacgtaat tttatatatt tacactattt tgtgaataat
    15901 tgcgcagcaa tcagttttac ccgcacgagc gggggtgatc ccagtgacaa caacgaatca
    15961 gatacagaaa tcatgtttta cctacacata tagacttgtg atgttagacc gattgaaatt
    16021 gattcttttg gatagaagga aatcaaatat atatattaag tggatgacaa taaaagtaaa
    16081 atattagata atagagatta agaattataa agaattggaa aatgtttagt cgtcaaacct
    16141 aaaatcatta taatgatacg aatatttttt tgatcaattt tgtgataata taaagaagcg
    16201 acatgcttac caattatttc aatctgatag aggtaataat gaaactttta tataccgaca
    16261 ttccatacaa cataacagag attttggccg aggaagcaca aatagctgct aaggctggca
    16321 agcgggtctt ttatattgct cccaactcct tgtcttttga gaaggagcga gctgttttgg
    16381 agaccctgcc tgagcgggct tcctttgcta ttaccattac gcgttttgag caaatggcac
    16441 gctattttgt tttaaatgat attcatcagg gcgaaaccat tgatgataat ggacttgcca
    16501 tggtttttta tcgtgcttta tccagttttt cagaccaaga tttgcgtgtt tttgggcgtc
    16561 ttaagcaaga tgctcatttt atcaatcaat tggtggattt gtataaggaa ctcaaggctt
    16621 ctaatctgac tgtcttagaa ttaaatcagc taaattcggc tgaaaagcag gaagatttga
    16681 ttaagatttt tacagaggtt gaaacaattt taagtgctgg ccattttgat aatcaaagca
    16741 agattgcctt ctttgcacaa cagatcaaat tcggtcattt agatacggct ttgcaggatc
    16801 tgacaattgt tattgatggt ttcacacgtt tttctgctga agaagaaaac ctgataggac
    16861 tgttatatga aaaaggtgtt gacattatca ttgggactta tattagtcaa aaagcttatc
    16921 gttcaacttt ttcgaatggg aatgtctatc aggctagcct tgatttcatt cgtggtttgg
    16981 ctggtaaatt tcaaaccaaa ccagaatatg tggtatcgaa gcaagaagct ttgcctgcct
    17041 ttaccaaact ttctcagcta tttgaaagtc gtcatgattt ttcggacagt cagctggtct
    17101 tgacagataa ggacaaggaa catgtaacta tctgggatgt cattaatcaa aaagaagaag
    17161 tggaacatgt tgctaagagc attcgccgga aactctatga aggtcatcgt tacaaggata
    17221 ttttggtcct tcttggggat gtggatgcct ataaactgca gattggcaag atttttgata
    17281 agtatgaaat tccctattat tttggcaaag cggagtccat gagttcgcac ccgctggttc
    17341 attttgtgga ttctttggag cgggttaaac gttataattt tcgtgctgag gatgtcatga
    17401 atctgctcaa atcaggccta tatggcaaaa tcaggcaaaa tcagttagat aaattggagc
    17461 agtatgtcac ttatgctgat attaaaggaa aaacaaagtt ttttaaggac tttacgctag
    17521 ataatcatgg gcaatttgat ctaaaagcct taaataaact gcgggcagaa gtcatgtcac
    17581 ctttacaaga gctggttaaa atacaggccc aaaagggaga cagtatcctg caaaaattga
    17641 ccaacttttt agaagccatt tctttaacga ataatttttc aaaattaatc caaggtgtca
    17701 gtgacactga gcaggaaaag aacgagcaag tttggaaaac ttttacggtt attttagagc
    17761 aatttcatac gatttttgga caagaaaaaa tgaagttggc tgattttctg gcactcttac
    17821 gcagcggcat gctggcggct gattatcgga cggttcctgc cagtgttgat gttgtgacag
    17881 ttaagtctta tgatttggtg gagccccata gcaataaatt tgtttttgct ctgggaatga
    17941 cccagtctca ttttcctaaa attgtccaaa ataagagtct tatttcggat gaagaacgtg
    18001 caaaaatcaa tgaagcaact cctgacaatc gtcgttttgt tattgtcact aaggaaaatc
    18061 tcaagaaaaa tcatttcacc gccctgtcac tcttcaatgc ggccactcag gaattggtct
    18121 taaccttgcc gcagatttta aacgaggcag aggacaacac ctcctcctat ttgcttgaat
    18181 tgcaagatat gggtgtgcca gttgtcgaaa aggggcgcaa tcgtttagct gcggatccag
    18241 aagatattag caattacaag gcgcttttgt cgcgtgtgat tgagcttaac cgctctgcta
    18301 ttgaccaaga attatctaaa gaagagcaga ccttttggtc agttgctgtt cgctatttac
    18361 gccaaaaatt ggcaaaagaa ggacttacga ttcctgaagt gaacgacaag atgcagacca
    18421 agcaggtcgc tgcagaggtt atggcagcac gttttccaat agatcaacct ttaaatctat
    18481 catcgtctgc cctgacaact ttttacaata atcagtatct ctatttcctt caatatatcc
    18541 ttggtttgca agagcttgaa acgattcatc ctgatgctag aaatcatggg acttatttgc
    18601 accgtgtgtt tgaattggtt atgcaagatc aatctactga tgattttgac agtaaattaa
    18661 atcgtgccat tgatataacc aaccatgagg atagctttca cttggtttat aatgaagatg
    18721 aggaaagtcg ctatgctttg ggtattttag aagatattgc tcgtagtacg gctaccattt
    18781 taaaagggga taatcctgtt caggcagaaa gtgaagaaga agcctttgag ttaatgctgg
    18841 atcaggctgt taaaatcaga ggggttattg atcgcattga tcgcttgtca gatggcagtt
    18901 taggaattgt tgattataag tcaagtaaaa atacctttga tctgcaaaaa ttttacaatg
    18961 gactcagtcc gcagttagtg acttatatag aagctcttcg gtcttgtaaa aatttgaatg
    19021 agacagataa gatttttgga gccatgtatc ttcatatgca ggaacctaaa actgatttag
    19081 ccaatatgaa atccatcgaa aaaattccgg aaatagttca taaaaattta agttataagg
    19141 gactcttttt agaagatgaa aaagcacatt tggctaatgg gaaataccat ttgcatgatg
    19201 ctgtctatag tcaaaaagaa gttgatttgc tgcttgatta taataaaaga ctctatcgca
    19261 gtgccgcaaa gcaaatcaga aaaggaaact ttctcattaa cccctacagt caggatggca
    19321 aatctgttca gggagaacag ctgaaggcta ttacacattt tgaagcagat cgccacatgc
    19381 cttatgctcg taaactttat cagctgccac gcaaagaaaa acgtcagggt ttcttggcgt
    19441 taatgcagtc taaaaaagag gaggaaggca atgaccttta aaccattttt aacagatcaa
    19501 gaaatagctt ccttacagat tcaagaagct cagtctgata agaaacaaaa acgaacgcct
    19561 gagcaaattg aggctattta cacttcagga accaatattt tggtttctgc ctctgctggt
    19621 tcaggaaaaa cctttgtgat gattgagcgg attatggata aaattctgcg tggtgtaacg
    19681 attgatcagc tttttatttc cacctttacc gttaaggctg ctggtgagct taaggagcgt
    19741 ttagaaaaga aaatcaccga gcaattgcgt ttgacaaatg acactgccct caaacaattt
    19801 ctcagcgaac aactcttggg attgcagact gcggatattg gaaccatgga tgcctttacc
    19861 caaaaattag tgacacagta cggctatacc ttgggaattt caccgaattt tcgaatttta
    19921 caagataaaa gcgagcagga tcttcttaaa aatgatgtct ttgacgacct ttttactgat
    19981 tacagaactg gcgatcaagc agagcttttc actaagcttg ttaggaattt tgctggaaat
    20041 cgaaaagatt cgagcaattt tagacaaatc atttacaaaa tttatgattt cagtcaggca
    20101 accgataatc cccaaagatg gcttttggag aatttcttaa aaggagccaa tacctataag
    20161 gatttttcag ctattcctga acaagaagtg aaagactttt tgaatacttt gcaggaaact
    20221 gctctcgctc ttcgtgatgt gacggattta gaagattaca agcaagtaac ggctaaagga
    20281 actccaacag cagcttatca aaggcacctt aaaatgattg agcagctgca ggattgggtc
    20341 ttgcattttg acagtctata tgggcgagat ggtctgggga aattagcaaa tgacattgca
    20401 acactcattc catctggtaa cgatgtgaca gtagcaggag ttaaatatcc tgtctttcgc
    20461 agtttgcaca gtcgcttaag aggactaaaa cacttggaaa caattttcaa gtatcaggat
    20521 caaagtctgc ctttgttaca agtactgcaa tcttttaccc ttgatttttc aaaacaatac
    20581 ctgcaagcaa agatgcagga aaatgccttt gagttttcag acattgcaca ttttgctatc
    20641 cagattttag aagaaaatga tgctattcgt cagctttata tagataagta tcatgaagtc
    20701 atggtagatg aatatcagga taataatcac acccaagagc gcatgttgga acttttatct
    20761 aatgggcgca atcgcttcat ggtaggagat attaagcaat ctatctatcg gtttcgtcag
    20821 gcagatccac agatttttaa tcaaaaattt aaggattttc aagaacatcc agagcatgga
    20881 aaactcattc tcttaaaaga aaactttcgg agtcagtcag aagtcttaga tgctaccaat
    20941 agtgttttta cgcaccttat ggacgaaacg gttggagaaa ttctctacga tgatacccat
    21001 cagcttgtgg ctggcagttc agctcagaaa attccttatc cgcaaaatga aacacaagtc
    21061 ctcatctatg atacaaagga tcaacaaaat caagatcttg ctgtagaaga tgatagtgat
    21121 caaatcagtc taggtgaggt caaattggtt gctaaggaga ttattcgcct tcataatgaa
    21181 gaaaaggttc agtttgaaga tattaccttg cttgtctcat cgcggacacg caatgatggt
    21241 atcttgcaaa cctttgatga ttatggcatt cctttggtga ctgatggtgg tgaacaaaac
    21301 tatctgaaat cagtggaagt tatggtcatg ttggatactc tgcgttctat tgataatcct
    21361 ctcaatgatt atgctctagt agctcttttg cgttcaccta tgtttgcttt tgatgaggat
    21421 gacttggctc gtctagctct gcaaaatcta ccagatcaac acaaacaaaa tctttatgaa
    21481 aagatggaga atgccagaaa tggccaaggc cagcaagttc agttgatcac agaagcattg
    21541 tctgccaaat tggatgcttt ctttgaaact ttcctcagtt ggcgtgagtt tagtctcttg
    21601 aattcgctct atgatttgat ttggaaaatt tataatgata agttttacta tgattatgtg
    21661 ggaagtttac caaaatctga acagcgccaa gccaatcttt atgctctagc cctgcgtgcc
    21721 gataactttg agaaaacagg ttttaagggg ttgtcgcgct tcattcgcat gattgacaaa
    21781 attctagaaa atcaaaatga cttggctgat gttgaagtcg ctttacctaa aaatgcagtg
    21841 acgctgatga cgattcataa gagtaaggga ttggaattta aatatgtctt tattcttaat
    21901 attgataaaa aatttagcat tcaagatatg acatcaccct taatcttatc gcggcaaaac
    21961 ggtgttggta tcaagtatat tgctgatatg aaagaagaac tagaggaaaa attattgcca
    22021 acagttaaag tcagcatgga tactcttcct tatcaactga ataagcgtga gcttcgtctg
    22081 gcaaccctat ctgaacaaat gcgattgctt tatgttgcca tgacacgatc tgaaaagaaa
    22141 ctttacttgg tcggaaaagg cagtcaggaa aaattagggg atcagtatga tggcaaatca
    22201 gaaaacaatc atttgccagt agctgatcgt gaacactatt tgacttttca ggattggctt
    22261 ttggcgattg aagctgctta tgctgccgat gaacttcatt ttaaaacaag ttttataacg
    22321 gatgaagact taacagaaga taaaatggga agtttagaag cagagcaggc ttatgatgcg
    22381 gataatctta aggataatcg gcaatcagat aatattgcgc gtgctttaga tatgttagaa
    22441 gcagttgaaa aattaaatca acattataag gctgctatcc atttaccaac tgttcgtac
//
