LOCUS       NZ_CP023477            22787 bp    DNA     circular CON 18-JUL-2024
DEFINITION  Streptococcus mutans strain LAR01 chromosome, complete genome.
ACCESSION   NZ_CP023477
VERSION     NZ_CP023477.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 2088369)
  AUTHORS   Abranches,J., Lemos,J., Kajfasz,J. and Aviles-Reyes,A.
  TITLE     Whole genome sequence and phenotypic characterization of a Cbm+
            serotype e strain of Streptococcus mutans
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2088369)
  AUTHORS   Abranches,J., Lemos,J., Kajfasz,J. and Aviles-Reyes,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-SEP-2017) Oral Biology, University of Florida, 1395
            Center Drive POBOX 100424, Gainesville, FL 32610, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: celera v. 9/01/15
            Genome Coverage                   :: missing
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002995555.1-RS_2024_07_18
            Annotation Date                   :: 07/18/2024 01:10:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,086
            CDSs (total)                      :: 2,002
            Genes (coding)                    :: 1,930
            CDSs (with protein)               :: 1,930
            Genes (RNA)                       :: 84
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 41 of 72
            Pseudo Genes (incomplete)         :: 35 of 72
            Pseudo Genes (internal stop)      :: 29 of 72
            Pseudo Genes (multiple problems)  :: 25 of 72
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:47:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 351019
            Orig. end                         :: 373806
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023477.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Dr. Jacqueline Abranches.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22787
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22787
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22787
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12787](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12787
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            409..1848
                     /gene="gatB"
                     /locus_tag="CO204_RS01830"
                     /old_locus_tag="CO204_01830"
     CDS             409..1848
                     /EC_number="6.3.5.-"
                     /GO_function="GO:0016884 - carbon-nitrogen ligase activity,
                     with glutamine as amido-N-donor [Evidence IEA]"
                     /codon_start=1
                     /gene="gatB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019314904.1"
                     /locus_tag="CO204_RS01830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01830"
                     /product="Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase
                     subunit GatB"
                     /protein_id="WP_106006681.1"
                     /transl_table=11
                     /translation="MNFETIIGLEVHVELKTNSKIFSPAPAHFGEDPNANTNIVDWSFP
                     GVLPVMNKGVIDYGIKAALALNMDIHQRMHFDRKNYFYPDNPKAYQISQFDEPIGYNGW
                     IEIELEDGSTKKIRIERAHLEEDAGKNTHGADGYSYVDLNRQGVPLIEIVSEADMRSPE
                     EAYAYLTALKEIIQYTGISDVKMEEGSMRVDANISIRPYGQEAFGVKTELKNLNSFNFV
                     RRGLAYEEKRQAEVLRSGGQIQQETRRYDEATGETLLMRVKEGSADYRYFPEPDLPIFE
                     IEDEWIEKVRAELPAFPKERRAKYVNDLGLSAYDAAQLTNSKAISDFFEAALAQGVDAK
                     TASNWLQGDIAQYLNAENQTIDQIGLTPENLTELLQLVADGTISSKIAKKVFVHLAKNG
                     GSAKEYVKSAGLIQISDPAQLLPIIQEVFANNEKALNDYKGGNKNAAKSLVGQIMKATR
                     GQANPQVAQKLLNEELAKLTD"
     gene            <2095..2274
                     /locus_tag="CO204_RS10955"
                     /pseudo=""
     CDS             <2095..2274
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /locus_tag="CO204_RS10955"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="NSLYRWIQEYEKYGERAFPGQGSALRHAQFELKKLEKENKILQEE
                     LALRGSVRITQELY"
     gene            <2393..3346
                     /locus_tag="CO204_RS10820"
                     /pseudo=""
     CDS             <2393..3346
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001901474.1"
                     /locus_tag="CO204_RS10820"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="reverse transcriptase domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VQIISPFCKPRFSETSYGFRPNRSCEKVIVKLLEYLNDGYEWIVD
                     IDLEKFFDRVPQDRLMSLVHHIIQDGDTESFIRSYLYSGVVINGQRHKTLAGTPQRGNL
                     SPLLSNIMINELDKELENRDLHFV"
     gene            3451..4149
                     /locus_tag="CO204_RS01855"
                     /old_locus_tag="CO204_01855"
     CDS             3451..4149
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002294154.1"
                     /locus_tag="CO204_RS01855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01855"
                     /product="response regulator"
                     /protein_id="WP_002263491.1"
                     /transl_table=11
                     /translation="MSFESQLLKKHILIVDDDTSLNQSIKEVLMSRGFNNISSAYSIDE
                     GIDIFSVSKIDLIILDVMLPDGEGYLLAKYIRKSSDVPILFLTAKNSPDDEIKGLDSGG
                     DDFVTKPFLPKTLSYRIIALLRRSYKGESELIELTFCTIDLNNASVLKGNEHLSLTPTE
                     IQILRKLYVNKNHIVSTEAICDAVWGLENFGYEKSLMVHIRNIREKIEKNSSKPVHLIT
                     VKGLGYKLVI"
     gene            4250..5598
                     /locus_tag="CO204_RS01860"
                     /old_locus_tag="CO204_01860"
     CDS             join(4250..4691,4691..5598)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1026: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611514.1"
                     /locus_tag="CO204_RS01860"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="CO204_01860"
                     /product="IS3-like element ISSmu1 family transposase"
                     /protein_id="WP_086956939.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MKLTYEDKVLIYELKNQGYSLEQLSNKFGIKISNLSYMIKLIDHY
                     GIEIVKKGKNRYYSPELKQEIIDKVLLEGRSQIRVSLDYALPSHGMLPNWIAQYKKNRY
                     TIVEKTRGRPPKMGRKPKKKSEEMTELEQLQKELEYLRAENAVPKKVERTPIEGRKRAR
                     RKTEIVRGLVTEFSLDILLKIIKLARSTYYYHLKQLDKSNKDHAIKAEIQAIFTEHKGN
                     YGYRRMTLELRNRGFLVNHKKVQRLMKVLGLEARIRRKRKYSSYQGEVGKKADNLIQRQ
                     FEASKPMEKCYTDVTEFAIPASGQKLYLSPVLDGFNSEIIAYNLSTSPNLIQVKAMLEQ
                     AFTEKHYTNTILHSDQGWQYQHDFYHQFLENKGIQPSMSRKGNSPDNGMMESFFGILKS
                     EMFYGYEKTFKSLKQLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFT"
     gene            5651..6985
                     /locus_tag="CO204_RS01865"
                     /old_locus_tag="CO204_01865"
     CDS             5651..6985
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003050399.1"
                     /locus_tag="CO204_RS01865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01865"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_106006682.1"
                     /transl_table=11
                     /translation="MLVLLLNIVFVLAAMAYVNSQQYPPDTSETIASEITLSDGSYHVS
                     PKAKRLISQEKLWVMIIDKNTGREIFNINKPQQIGTHFNYADVVRFSRFYLHDYPVFTR
                     IKDDENAIYIVAFPKDSIIRYSYNFLESHRYRFIPILALGIISINVLLCLFLYIYSVTF
                     LNRNIRPIINAIGKLPSGLNTQVNSVKELDRLALAVNSANQQLRENEEFKENWISGIAH
                     DIKTPLSVIVSNTSLAIEKTDNESLLKHLNPTLVESHYIQNLLNDLNIFARLTNGNLEL
                     KKEIVTIIPFFKEIIIQIVNQDVWEEFQFEFDAESNLSGKKMYVEKALISRVIHNLIYN
                     SVLHNSHGCTIKIELKSYSDDNFKITVQDNGVGTSLEKLKNINKIEEFTFDISGVRRSG
                     MGLKISKQIIDLHNGDMIIKSEQGRYFKTDIILPIAFTSGSDNLL"
     gene            complement(7564..8820)
                     /locus_tag="CO204_RS01870"
                     /old_locus_tag="CO204_01870"
                     /pseudo=""
     CDS             complement(7564..8820)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002948696.1"
                     /locus_tag="CO204_RS01870"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01870"
                     /product="ISL3-like element ISSmu2 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRLIKNTTELIGIKDPNIIIFLVFETNTHIESQAKRNYPAPSCPH
                     CQGKMIKYDFQRPSKIPLLEQAGTPTLLRLKKRRFQCKGCKRVMVAETSIVEKNCQISN
                     LVRQKVAQRLTEKVSLTDIARRLRVSTSTVYRKLDQFTFKEHYDRLPRVMFWDEVGFKK
                     GELAFVAQNYETNELITILDNRRQTTIRNYFLKYPLKVRQEVRFITMDMSGAYIPMARK
                     LFPNAKIVLDRFHIIQHLGRAFLKTRIAIMNQFDKKSLPYRALKNHWRLFQMDSRKLSL
                     NSFYSKTFRQTLNPHEVVEKTLDFSEELTDYYTLYQLLLFHFQEKRAEEFFELIEENMS
                     KVNHYFQTIFRTFLKHK"
     gene            9096..9254
                     /locus_tag="CO204_RS01875"
                     /old_locus_tag="CO204_01875"
     CDS             9096..9254
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268660.1"
                     /locus_tag="CO204_RS01875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01875"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_106006683.1"
                     /sec_met_domain="L_biotic_A (E-value: 9.9e-28, bitscore:
                     92.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 1.7e-05, bitscore:
                     21.7, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNTTNEMLELIQEVSLDELDQVIGGMGKGTVGTISHECRYNSWA
                     FLATCCS"
     CDS_motif       9096..9173
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNTTNEMLELIQEVSLDELDQVIGG"
                     /locus_tag="CO204_RS01875_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9174..9254
                     /prepeptide="core"
                     /locus_tag="CO204_RS01875_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.60"
                     /molecular_weight="2715.1"
                     /monoisotopic_mass="2713.2"
                     /core_sequence="MGKGTVGTISHECRYNSWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNTTNEMLELIQEVSLDELDQVIGG"
                     /leader_location="[9095:9173](+)"
                     /alternative_weights="2733.1"
                     /alternative_weights="2751.1"
                     /alternative_weights="2769.2"
     gene            9281..9433
                     /locus_tag="CO204_RS01880"
                     /old_locus_tag="CO204_01880"
     CDS             9281..9433
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002269377.1"
                     /locus_tag="CO204_RS01880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01880"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_002269377.1"
                     /sec_met_domain="L_biotic_A (E-value: 1.1e-21, bitscore:
                     73.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 1.6e-05, bitscore:
                     21.8, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQSDEMLELIQEVSLDELDQVIGGAGNGVIRTITQGCRMPNNMQ
                     VLFTC"
     CDS_motif       9281..9355
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKQSDEMLELIQEVSLDELDQVIGG"
                     /locus_tag="CO204_RS01880_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9356..9433
                     /prepeptide="core"
                     /locus_tag="CO204_RS01880_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.60"
                     /molecular_weight="2671.1"
                     /monoisotopic_mass="2669.3"
                     /core_sequence="AGNGVIRTITQGCRMPNNMQVLFTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKQSDEMLELIQEVSLDELDQVIGG"
                     /leader_location="[9280:9355](+)"
                     /alternative_weights="2689.2"
     gene            9473..9628
                     /locus_tag="CO204_RS01885"
                     /old_locus_tag="CO204_01885"
     CDS             9473..9628
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002296231.1"
                     /locus_tag="CO204_RS01885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01885"
                     /product="lacticin 481 family lantibiotic"
                     /protein_id="WP_002296231.1"
                     /sec_met_domain="L_biotic_A (E-value: 1.6e-27, bitscore:
                     92.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 1.7e-05, bitscore:
                     21.8, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQSNEMLELIQEVSLDELDQVIGGMGKGAVGTISHECRYNSWAF
                     LATCCS"
     CDS_motif       9473..9547
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKQSNEMLELIQEVSLDELDQVIGG"
                     /locus_tag="CO204_RS01885_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9548..9628
                     /prepeptide="core"
                     /locus_tag="CO204_RS01885_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.60"
                     /molecular_weight="2703.1"
                     /monoisotopic_mass="2701.2"
                     /core_sequence="MGKGAVGTISHECRYNSWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKQSNEMLELIQEVSLDELDQVIGG"
                     /leader_location="[9472:9547](+)"
                     /alternative_weights="2721.1"
                     /alternative_weights="2739.1"
     gene            9822..9983
                     /locus_tag="CO204_RS01890"
                     /old_locus_tag="CO204_01890"
     CDS             9822..9983
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_d"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) lacticin_mat"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268661.1"
                     /locus_tag="CO204_RS01890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01890"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_002268661.1"
                     /sec_met_domain="L_biotic_A (E-value: 4.3e-24, bitscore:
                     81.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="mature_d (E-value: 1.7e-09, bitscore:
                     34.0, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="lacticin_mat (E-value: 9.7e-09, bitscore:
                     31.6, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKGTQLYLEALEALQEIKVEELDTFIGGGGRASNTISSDCRWNS
                     LQAIFSCC"
     CDS_motif       9822..9908
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKGTQLYLEALEALQEIKVEELDTFIGG"
                     /locus_tag="CO204_RS01890_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9909..9983
                     /prepeptide="core"
                     /locus_tag="CO204_RS01890_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.70"
                     /molecular_weight="2468.7"
                     /monoisotopic_mass="2467.1"
                     /core_sequence="GGRASNTISSDCRWNSLQAIFSCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKGTQLYLEALEALQEIKVEELDTFIGG"
                     /leader_location="[9821:9908](+)"
                     /alternative_weights="2486.7"
                     /alternative_weights="2504.8"
                     /alternative_weights="2522.8"
     gene            10001..12787
                     /locus_tag="CO204_RS01895"
                     /old_locus_tag="CO204_01895"
     CDS             10001..12787
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303301.1"
                     /locus_tag="CO204_RS01895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01895"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_002293694.1"
                     /sec_met_domain="DUF4135 (E-value: 8.4e-77, bitscore:
                     255.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-52, bitscore:
                     175.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQKELLYSQFDVFNKQVIERYLPEVLDESDDIIQDIEEQISDYY
                     RSTLIYLINEKRIDGSLIGSSPESRYNYFTNVLCQQGMILDEIEERFPTITQRVVISLK
                     KYLELSKYVKEAFTADFSELLAEGYLDGVASDISSDDVKIKITGDIHNGNGVCIVAYQG
                     KKVVFKKKSSQPNQLLQTLEREVSQYLDKEVYFISPFLDKGEYFWEKFVSSKPLLSEEE
                     AKEFYCRVGYLLACAYMLNISDLHFENLISSHINPILVDVETVFSTSTFDTIANNDATF
                     KIIESSRDSVLFTGLLPVSEADKVFGGDTSGVLGGIMIGEARIVINHNRDDIRIEKQKY
                     KTENQDHLPYFSDSEGVKTYLNAEDYVDFIKSGFSELSEFFMHRKEFLKTLYSEYGHLQ
                     TRLLFRNTRDYSLIRQLLTSPVYCEQSHVLFEKMEDKFSEVDSHELCQSEEKQLLNMDI
                     PYFYAEIASRDVRDDEGIVWQLTRTALSQVIKKLDNLSSAVINEQLDLIEFSIKTPNAL
                     YSTELQDAYRDFENNQQTQDQDVLISGINELTDVILENEKNSQEDGSTNWLTLKVTDYD
                     AFELVPMDDSVYDGLAGMAIALSEVYDLVDDIRQEKIRLCLQRIFTTLSNSYLELQNQS
                     YFVGKLGLFSALSRISPITGQELPDFVLDGDQDYLVDLDVSTADFLSSFTNEVVALRNS
                     DIKIGNLNQALDKLDELKIISEDFISWDKLESNNVSLAHGNLGVEVALLCLAGNLERPE
                     ALQLFRKAKRFDDRQRLENGWVDKRNSDTSANWCHGSTGVLVARLVQLRLDDRYKLLSP
                     SERTALEADLQHASKQIIDLGFDMTNFSLCHGTSGNLLALSYYQSYLPENDAQRLRAIL
                     DKEYRKLHAFGLTKGWMCSFNTKYNVYGLMTGLPGILYSTAKFLKGDDSLDVLIPNL"
     gene            12810..14882
                     /locus_tag="CO204_RS01900"
                     /old_locus_tag="CO204_01900"
     CDS             12810..14882
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002268663.1"
                     /locus_tag="CO204_RS01900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01900"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_002293695.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.4e-38, bitscore:
                     126.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIILQNNEEDCLLACYTMLLNDLGHKVPLYEVYDKDTLPADGLS
                     VSYLLSLNDRFGVTINAYRASFDELLKVYRQRKQRMILHWNQEHFVILEKITSKQVTIV
                     DPAIGRVKYSRDEFLSHYSETMILVKRGDYFQPQSYKQIFWKYFRKTLKLKPVSFFLVS
                     LLFIQTGVLLFSVALRQMLADDFKFWVSMSLLAIVLLFQLIGYFIKNIALDRYNTDFDD
                     NYSKALFQKLLKKPLLYFRNHLNGGVSEKINFKSTLRDNVTLKIIPSCVSFISAIVVFA
                     YLMTISIKLTLILMTMIAIYAVISILLYRKQNEHNQAYLQYLIDFNSELQTDLDDIDYI
                     KIMRREGLTFGSWMRSNQQVTTKYSQILKIENLSQIIGTFFNYISLSSIIVIAVYYKVY
                     IKVSLPDLLVYQTSISLLISSIEQVKGAVFEITRLGVYAEKQSDLLKDSKPITVPSSGS
                     ADYLIKAEHLNFSYGAKKVYSDVNLTVNKGEKIAIVGKSGSGKSTLLLLLAGILRYDGS
                     LEYGVKNFEDYLSVVLQNMTPRKGSILENLEWSYDDLAPVYQVMKDTSADEIINQLPNK
                     IHSKLLKQGKNLSGGQIQKLLITKSLLKENAIIFWDEAFSNLDEQSKNKIYNNVLQNDR
                     YSERTMLIISHHLDIVNYVDYIIYIDAATGDVIKDSHNHLMQSNENYADFITSKI"
     gene            14997..15905
                     /locus_tag="CO204_RS01905"
                     /old_locus_tag="CO204_01905"
     CDS             14997..15905
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263495.1"
                     /locus_tag="CO204_RS01905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01905"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002269654.1"
                     /transl_table=11
                     /translation="MDNVIELQNLTKVYNGVTTVDLKKITVHQGEIYGFLGPNGAGKTT
                     TMKMILSLIAPTSGNVLVNDSNIKKDVAYLDQIGSMIEEPSYYPNLTGYENLLVFQKML
                     SFDKNNIWPTLELVGLADEKNTKKLVKAYSLGMKQRLALAFALVKRPKILLLDEPTNGL
                     DPAGIHEIRELIVTLAKEKGLTVFISSHILSEIEHIADRVGIINHGRLVYEGAIEAIQS
                     NAWIEIGGDFSTGDITTALNEYGLVRVLDIAANKLTLDDFSNNDLADFVTYLVEKGFRI
                     FRVVRETETLEDIFLNLTTEV"
     gene            15907..16659
                     /locus_tag="CO204_RS01910"
                     /old_locus_tag="CO204_01910"
     CDS             15907..16659
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019317089.1"
                     /locus_tag="CO204_RS01910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01910"
                     /product="ABC transporter permease"
                     /protein_id="WP_002269653.1"
                     /transl_table=11
                     /translation="MTKAIKVEWLKSKRTKSLTVSTLIILIGVFWSILGTVMQKSSSGW
                     EMFFDNQDALPMFLPLAISIFVSRIISNEKEGRTFKLQASNAHGILEIFHNKLWFTSLF
                     FFSMAVVYTSIISFYVTFIKGESISGLAPVHQIVTFTLGSFVQICLYIVMAMIMEKQSA
                     VLATGFLGAFVGIVFQRLSMKFWSFFIPWLGTSFLAMYHFGYDDKTETAFATLDNQIFL
                     KLIVYSMYAVLCYLAARYIVSHKGGELL"
     gene            16659..17390
                     /locus_tag="CO204_RS01915"
                     /old_locus_tag="CO204_01915"
     CDS             16659..17390
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002263497.1"
                     /locus_tag="CO204_RS01915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01915"
                     /product="ABC transporter permease"
                     /protein_id="WP_002269652.1"
                     /transl_table=11
                     /translation="MKYLSSEWLKLRKLQLLLVGLILLSIGSFVGLGTYYANRQVFIHD
                     TQSRVMWGQLTFYHSQVFYPALLAIFVGISLMPEFERMTFEMLKANNVSIGKLLMSKLL
                     TLTFTLVPFQFLLVVIWWVGLKLDNISVTSEIGVHIKWVLLSLIGSLSILSLQSFILVK
                     TKSFAKSVGFSAMGVMVGFVLMLVFEPLSHIFPYSQPMIGLRARALADMSFSEFVIFIV
                     VNVFYTLLFYKLTQRTLEKKG"
     misc_feature    complement(17482..17495)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.03"
                     /tool="antismash"
     gene            <17755..17859
                     /locus_tag="CO204_RS01920"
                     /old_locus_tag="CO204_01920"
                     /pseudo=""
     CDS             <17755..17859
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002264751.1"
                     /locus_tag="CO204_RS01920"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01920"
                     /product="site-specific integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="HASMTTTQKTYLHIIRELENQDIDLIMRSLTSLT"
     gene            17954..18862
                     /locus_tag="CO204_RS01925"
                     /old_locus_tag="CO204_01925"
     CDS             17954..18862
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002274361.1"
                     /locus_tag="CO204_RS01925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01925"
                     /product="DMT family transporter"
                     /protein_id="WP_106006684.1"
                     /transl_table=11
                     /translation="MKKSFKGTILVVLAAIAWGISGVSGQFLMKQGISVYLLTSLRLLI
                     SGLLLIGVVIWQQPQQIKAILEDKKVLAGIFGFSICGLLLNQFSYLQAIHYTNAGTATV
                     LQYMAPVLVLTVICFRDRSLPTMGELTAILLAILGTFVIATYGQMGNLALSPVGLFWGL
                     FSAVTYTLYMLLPIKLIQEWGSLLVIGLGMLLGGLVFSLVSQSWQYNPQFQANNLLAYV
                     GLIIVGSVFAYTSFLKGVSLIGAVKGSLLASIEPIAAVFFSVTLMKEIFYPIDFLGMLL
                     IILAVLIISIKDLLATNKEKV"
     gene            complement(18893..20062)
                     /locus_tag="CO204_RS01930"
                     /old_locus_tag="CO204_01930"
     CDS             complement(18893..20062)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019803049.1"
                     /locus_tag="CO204_RS01930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01930"
                     /product="macrolide family glycosyltransferase"
                     /protein_id="WP_019313402.1"
                     /sec_met_domain="MGT (E-value: 1.7e-30, bitscore: 103.5,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKKTHYNILMVNLPFSGHTNPTLELAQILVQLGHNVTYINAPDW
                     QSKIERTGAHFVPYDHYPDSLSERQKNVKSWSAAYQTVLRMGKDYDCLLYEMLFFPGKA
                     LADRLNIPAYRLFSTFSLNEKILSEFGKTGGFYLTSIFRFTFLRHLLSRKLQRTFQLAY
                     DDLAKEISLNTPELNFTYTVREFQIDADTFDENHYQYVGPSINRPVEPPFDFTPFKNPI
                     IYISLGTLLNRSVSFFKKCIKAFENEPYSIIISLGNRIKKEQLGTMPANVHLYSFVPQL
                     QILERASLFLTHGGMNSVNEAIYYGCPMLVIPVGNDQPRVAQQVADLHLGKYLKRHNLN
                     PQKIKQAAHTILKDSSYKNTILHFQKIAQTAGGNTLIAQTIIKDLQTKP"
     gene            complement(20040..20690)
                     /locus_tag="CO204_RS01935"
                     /old_locus_tag="CO204_01935"
     CDS             complement(20040..20690)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002313160.1"
                     /locus_tag="CO204_RS01935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01935"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_019313401.1"
                     /transl_table=11
                     /translation="MKQEAKTQLSKKRIAQTAMTLFLQKGYEETTMREIVHKSGRSKGA
                     IYHHFSSKQEILNFQISLEMDNLRQCLDALISNNQLNAQQKFKGILTYFFENPSLTGLT
                     RLHWAEKIPFALLETLKNSLTVVAQYIEAIIQQEIKEKKLNCQYSKELSEILVLLFDIW
                     LDPSIVDFDYQTACQRIDFIALLLEKFGLPLLDENDKNKLKNGLKHYDEKNTL"
     gene            20962..21489
                     /locus_tag="CO204_RS01940"
                     /old_locus_tag="CO204_01940"
     CDS             20962..21489
                     /GO_function="GO:0008962 - phosphatidylglycerophosphatase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019315482.1"
                     /locus_tag="CO204_RS01940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01940"
                     /product="YqeG family HAD IIIA-type phosphatase"
                     /protein_id="WP_002272668.1"
                     /sec_met_domain="HAD_2 (E-value: 6.2e-12, bitscore: 42.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIENYRPDFVVEAVYDLTPDSLRKHGIKAVLVDLDNTLIAWNHP
                     DGTPQLRDWLDSMTEADMPVVVVSNNSYTRVKRAVKGFHVDFVSRALKPFSRGINIAVN
                     RYGFSKDEVVMVGDQLMTDIRAAHRAGVKSILVKPLVKSDAWNTKFNRARERRVWKKIE
                     DKYGAFVYKKEI"
     gene            21490..22596
                     /gene="yqeH"
                     /locus_tag="CO204_RS01945"
                     /old_locus_tag="CO204_01945"
     CDS             21490..22596
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="yqeH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018363769.1"
                     /locus_tag="CO204_RS01945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CO204_01945"
                     /product="ribosome biogenesis GTPase YqeH"
                     /protein_id="WP_002279411.1"
                     /transl_table=11
                     /translation="MEELFCIGCGAQIQTTAKEQAGYTPKSALEKGLESGKIYCQRCFR
                     LRHYNEITDVHISDDDFLKLLHEVGDSRALVVNVIDIFDFNGSVIPGLQRFISSSDLLL
                     VGNKADILPKSVKSGKITQWLMERAHEEGLRPLDLILTSAQNKWAIKELIAKIEELRQG
                     RDVYVVGVTNVGKSTLINAIIQEITGDKNIITTSRFPGTTLDKIEIPLNDGSYIFDTPG
                     IIHRHQMAHYLSDKALKYISPKKEIKPKTYQLNPEQTLFLGGLARFDYVTGDKQGFTAY
                     FDNNLKLHRTKLAGADAFYDKHIGSLLTPPDKKEMAAFPKLVRHEFTIKEKTDLVFSGL
                     GWIRINGRAKIAAWAPEGVAVVTRKALI"
ORIGIN
        1 aaaacgtcgt attatgctgg gaactttcag tctttcttca ggttattatg atgcctattt
       61 caaaaaagct ggtcaagtac gaacacttat catggaagat ttcaagaagg tttttgccaa
      121 ctacgattta attttaggtc caacagcacc aactgttgct tatgatttgg attcgcaaca
      181 ccaagatcct gttgctatgt atttagctga cttgttaact attccagtaa acttagctgg
      241 tctgccaggc atctctatac ctgctggttt tgtggaagga ttgcctgttg gtatgcaact
      301 aattggaaaa ccatttgctg agcaaaccat ctatcaagca gcggcagctt ttgaagcaag
      361 tacggattat cataaacaac aaccagttat ttttggaggt ggcaactaat gaattttgaa
      421 actatcattg gattagaagt ccatgttgaa ttaaaaacaa attctaaaat tttttcacct
      481 gcaccagcgc attttggaga ggatccaaat gctaatacga atatcgttga ctggtcattt
      541 ccaggtgtct tgcctgttat gaataagggt gttattgatt atggcatcaa ggctgcactt
      601 gctctcaata tggacattca ccaacgcatg cactttgacc gcaagaatta tttttatcct
      661 gataatccca aagcctacca aatttcacaa tttgatgaac ctatcggcta caacggttgg
      721 attgaaattg aattagaaga tggcagcacc aagaaaattc gcattgaacg cgctcacttg
      781 gaagaagatg ctgggaaaaa tacgcacggt gctgatggtt attcttatgt tgacctcaac
      841 cgtcaagggg tccctttgat tgaaatcgta tcagaagctg atatgcgttc acctgaggaa
      901 gcttatgctt atttaacagc ccttaaagaa attatccaat acacaggaat ttcagatgtc
      961 aaaatggaag aaggctccat gcgggtggat gccaacattt ctatccgtcc ttatggacag
     1021 gaagcatttg gtgtcaagac tgagttgaaa aacttgaact ctttcaattt tgttcgtcgc
     1081 ggtttggcct atgaagaaaa acgtcaggca gaagtccttc gttctggagg tcaaattcag
     1141 caagaaacac gccgttatga tgaagcaaca ggggaaacct tgttaatgcg tgtcaaagaa
     1201 ggttcagcag attatcgcta cttcccagaa ccagatctac caatttttga aattgaagat
     1261 gagtggattg aaaaagttcg agcagaatta ccagcctttc caaaagaacg ccgtgctaag
     1321 tatgtcaatg acttaggatt gtcggcttat gatgctgccc aactgaccaa ctcaaaagcc
     1381 atttcagatt tctttgaagc agctcttgct caaggtgtag atgcgaaaac agcttctaat
     1441 tggttgcaag gagacatcgc tcaatatctc aatgctgaaa accaaaccat tgatcaaatc
     1501 ggtttgacac ctgaaaattt gactgaactg cttcagttag tagcagatgg aaccatttct
     1561 tctaaaattg cgaagaaggt cttcgttcat ttagctaaaa atggcggttc tgccaaagaa
     1621 tatgttaaat cagcaggtct tattcaaatc tctgatccag cacagcttct gccaatcatc
     1681 caagaagtct ttgccaataa cgaaaaagct ttgaatgatt acaaaggcgg caacaaaaat
     1741 gcagccaaat ctctagttgg tcaaattatg aaagccacaa gaggacaagc caacccacaa
     1801 gtcgcgcaaa aattgcttaa tgaagaattg gcaaaattaa cagattaaaa tgtaattatt
     1861 ttgtttttac aaataaagcg agctgctttg aactgcacct caaaagttga acaagaaatt
     1921 atggcaagga ttggatttga tataataaag tggacacgaa gttaagtgaa aacgaggaaa
     1981 aatattatgc caagaaaagt atttgataaa gcattcaaaa tatctgcagt taaactcatt
     2041 ctagaggaag gatagtctgt aaagatggtt agttcaactt aagaggttca tccaaatagt
     2101 ttatatcgct ggattcaaga atacgaaaaa tatggagaaa gagcgttccc aggacaaggg
     2161 agcgctcttc gtcatgccca atttgaactt aaaaaactcg aaaaagaaaa taagatatta
     2221 caagaggagt tagctctccg tggtagcgtc cgaatcactc aagaactcta ttgatgagga
     2281 ataaaggtca atcgcaaacg tattgctaga ctacttcatg aactttgtct ctatgctaaa
     2341 ggaagccact ataaatacaa gtactataac cgtcggcgtt cttcattgag acgtccaaat
     2401 tattagtcct ttctgtaaac ctcgtttctc cgaaacgagt tatggattcc gacccaaccg
     2461 gtcatgtgaa aaagtcatcg ttaagctgct agaatacctt aacgatggct atgagtggat
     2521 tgtagacatt gacctagaaa agttcttcga tagggttccc caagacaggt tgatgtctct
     2581 tgttcatcat attatccaag atggcgatac agagtccttc attcgtagct atctctactc
     2641 gggtgtggtc attaatggac aacgacataa aacgttagca ggaactcccc aaagagggaa
     2701 cctatcacca ctcttatcca atattatgat taatgagttg gataaggaat tggaaaatag
     2761 ggatctacac tttgtctgat acgcagatga ttgtgtcatt acggttggga gtgaagcggc
     2821 cgctaagcga gtcatgcact ctgttagtcg ctttattgaa aagcgattgg gattgaaagt
     2881 caacatgatc aagactaaga ttgtgagacc aagaaagctg aaatatttgg gttttgggtg
     2941 ctgaaaattc tctgagggtt gggaaagtcg tccgcatcaa gatagtgtac agagcttcaa
     3001 gagaaaactc aagaaactaa ccactcgaaa atggagcatt gacctagata gtcacatcga
     3061 aaaactcaac tgggttatcc gaggttggat aaactatttc tccctgacta atatgaaatc
     3121 tgtcatgccg agtattgatg aaaggttgcg gacatgcatg agagctatta tctggaaaca
     3181 atggaagaag aaatccaagc gactatgggg acttcttaaa ttaggagttc caaggtggat
     3241 agctggtaaa ggatctggct ggggagacca ctatcaatta gtggcgccaa agtcagtcct
     3301 aaaacgtgct atatcaaaat cagtcctagc taaacgtgga ctttaaatta aagaaaagca
     3361 gagcaggtat tttagagata aaaacgaaca atttagtatt ggaaaaccag tgttatatgc
     3421 tataatgaaa gtaattttgg aggtgatagt gtgtcttttg aatcacaatt attgaaaaag
     3481 catatcctaa tcgtagatga tgatacatca ttgaaccagt ccatcaaaga ggttttgatg
     3541 agtcgagggt ttaacaatat cagttctgcc tatagtatag atgaagggat tgatattttt
     3601 tcggtatcaa agattgattt gatcatactg gatgtcatgt tgcccgatgg ggaaggttat
     3661 ttattggcca aatacattcg aaaatcgtca gatgtcccca ttttattttt aaccgcaaaa
     3721 aatagtcccg atgatgaaat caaaggactt gattcaggag gagatgattt tgtcaccaaa
     3781 ccatttcttc ccaagaccct gtcttatagg attatagcct tactgaggcg atcctacaaa
     3841 ggtgaatctg aacttatcga acttactttc tgcaccattg atttaaataa tgccagtgtt
     3901 ttaaaaggca atgaacatct atcactgacc cccacagaaa ttcagattct tcgcaaactt
     3961 tatgtcaata aaaaccacat cgtctccaca gaagcgattt gcgatgcggt gtggggactt
     4021 gaaaactttg gatacgaaaa atcattaatg gtacatatcc gcaatatcag agaaaaaatc
     4081 gagaaaaact cctcaaagcc agtgcatctc attacagtca agggtctcgg gtataagctg
     4141 gtcatttagg gggtaaggta tctaacatga atattttaaa aaggagtgcc ctatgaactg
     4201 caccccaaaa gttagacaga aaaaatctaa cttttggggt gtttttatta tgaaattgac
     4261 ttatgaagat aaagttctca tctatgaact gaaaaaccaa gggtatagct tagagcagct
     4321 ttcaaataaa tttgggataa aaatttctaa tcttagctac atgattaaat tgattgatca
     4381 ttacggaata gagatcgtca aaaaaggaaa gaatcgttac tattctcctg aactaaaaca
     4441 agaaatcatt gataaagttc ttcttgaagg tcgttcacaa ataagggtgt ctctagatta
     4501 tgctcttcca agtcatggaa tgttgcctaa ttggatagca caatacaaga aaaataggta
     4561 tactattgtt gagaaaacaa gagggagacc acctaaaatg ggacgtaagc caaagaagaa
     4621 atcggaagaa atgacagagc tagagcaact tcagaaagaa ttagaatatc tgagagcgga
     4681 gaatgctgtt ctaaaaaagt tgagagaact ccgattgagg gaagaaaaag agcaagaaga
     4741 aaaacggaaa ttgtccgagg attggtaacg gagttttctt tagacattct tctaaagatt
     4801 attaagctcg ctcgttcaac ctattattac cacttaaagc agctagataa aagcaataaa
     4861 gatcatgcta ttaaagctga aattcaagct atttttactg agcacaaagg aaattatggt
     4921 tatcgtcgaa tgactcttga attgagaaat cgtggcttct tggtaaatca taaaaaggtt
     4981 caacgtctaa tgaaagttct tggtttggag gctcgtattc gtcgcaaacg gaagtattct
     5041 tcctaccaag gagaggtggg caagaaagca gacaacctta ttcaacgcca atttgaagca
     5101 tcaaaaccaa tggaaaagtg ctacacagat gtgacagaat ttgccattcc agcaagcggt
     5161 caaaagctct atttgtcacc agttttagat ggtttcaaca gtgaaattat tgcttataac
     5221 ctttctacgt caccgaactt gatacaagtg aaagctatgc tagaacaggc tttcacagag
     5281 aaacattaca caaatactat tcttcatagt gaccaaggct ggcaatacca gcatgatttt
     5341 tatcatcaat ttttagagaa caaggggatt cagccgtcca tgtcacgtaa aggaaacagc
     5401 ccagataatg gcatgatgga atctttcttt ggcattttga aatccgaaat gttttacggt
     5461 tatgagaaga catttaagtc acttaagcaa ttggaacaag ctattgtaga ctatattgat
     5521 tattacaaca acaaacgtat taaggtaaaa ctaaaaggac ttagtcctgt acagtacaga
     5581 acgaaatcct ttacttaaat tttttgtcta actttttggg gtcagtacac taagatttgt
     5641 ctttttcttt atcttagttt tacttctcaa tatcgtcttt gtactagctg ctatggccta
     5701 cgtcaatagt caacaatacc cccctgatac ttctgaaacc atagcttctg agatcacttt
     5761 atctgatggc agctatcatg ttagtcctaa agccaaacgg ctgatttcac aagaaaagct
     5821 gtgggtcatg attattgaca aaaacacagg tcgggagatc ttcaatatca ataaacccca
     5881 gcagattgga acgcacttta actatgcaga tgttgttaga ttttcccgat tttacttaca
     5941 tgattaccct gtctttactc ggataaaaga tgacgaaaat gctatttata ttgtggcttt
     6001 tccaaaagac agtattatcc gatatagcta caatttccta gaatcacata ggtatcgttt
     6061 cattcctatc ttggctcttg gtataatctc tatcaatgtc ttgttgtgct tgtttctcta
     6121 catttacagt gtcacctttc tcaatcgtaa tattaggcct attatcaatg ccattgggaa
     6181 gttacctagt ggtttaaata cacaagttaa ttctgttaaa gaattagatc gattggcact
     6241 ggcagtcaac tctgccaacc aacaacttcg agaaaatgaa gaatttaaag aaaactggat
     6301 atcaggtatt gctcatgata ttaaaacccc cctctccgtt atcgtgtcta atacatcatt
     6361 agccattgaa aagactgaca acgaaagcct tcttaagcac ctaaatccta ctctggttga
     6421 aagtcactac attcaaaatc tactaaacga cctcaatata tttgctcgat tgacaaatgg
     6481 taacttagag ttaaaaaaag aaatagttac catcattcct ttctttaagg aaattataat
     6541 tcaaattgtc aaccaagatg tttgggaaga atttcagttt gaatttgatg cagaatccaa
     6601 cttatcaggt aagaaaatgt atgtcgagaa agccctcatt tctcgtgtta ttcataattt
     6661 gatttataat tctgtcctcc ataatagtca tggctgtacg ataaaaattg aacttaaatc
     6721 ctattcagat gataatttta aaattactgt acaggataat ggtgtaggaa catctctaga
     6781 aaaactgaaa aatatcaata aaatagaaga atttactttt gacatctctg gcgttagaag
     6841 aagcggtatg ggcttgaaaa tatctaaaca aatcattgat ttgcataatg gtgatatgat
     6901 tatcaaaagt gaacaaggca ggtattttaa aacggacatt atactaccaa tagcatttac
     6961 ttctggttca gacaatcttc tatgacgaat tgcaacatac atttcactta taagaatctc
     7021 gaaggctgtt ttgtaatcta aacattgcgt ggccaatgat taataacctc taaagtctgt
     7081 cctagttcct catctgtgat tactgctaag tctgttctcc taggacttcc gcagtaagtc
     7141 attggcattc tcgctgcctc ctctttatca agaagaatag ggaaaagaac ctcctagttt
     7201 ttctaagaca ggagagtttt aatttggttt ggattttctc ctttagctct ggtcgtgtag
     7261 ctcggttttt tctctttata cttagctagt tggtcatatt atttctatgc taattcagct
     7321 gaataagttt cattctgata acaattctct tgaaagtgtt gctctgcgca caccaatctt
     7381 tttagcgact tgacaaggct tcagtcctgg tttcagatat gtttctattt tttattagtt
     7441 atggtaagat gatgatagct cattgatttc tctcgtgttc tgttggtggg gttacttaca
     7501 gtttacacgt tttggaactc tatgagttta ggctcattgt caactgtagt gggtgacgaa
     7561 aagctaacat ctagagagga ccggaagggt cttctttttt tggatgttca gggtgatgaa
     7621 tacacgcttt ctaaagttga taaagtttct aaaaccaaat cccaaacgtt tgatgtcttt
     7681 aatcaacttg ttagtcgctt caagttttgc gtttgaatag tccgtttcta gtgcgttttt
     7741 gatgtattat ttgtgtttaa gaaaggtcct aaagatagtt tgaaagtaat gattgacctt
     7801 gctcatattt tcttctatga gttcgaaaaa ctcctccgct ctcttctctt gaaagtgaaa
     7861 aagtaaaagc tggtaaagag tatagtagtc ggtaagctct tctgaaaagt ctagtgtctt
     7921 ctcaacgact tcatgtggat ttaaggtttg gcggaaggtc tttgaataaa aagagttgag
     7981 agataactta cggctgtcca tttgaaagag tcgccagtga tttttcaagg ctcgataggg
     8041 tagcgacttc ttatcaaact ggttcataat tgcaattctt gtctttaaaa aggcacgtcc
     8101 aaggtgctgg ataatgtgaa atctgtcaag aacgattttg gcgtttggaa agagtttgcg
     8161 agccattgga atataagccc cagacatatc cattgtgata aatcgaactt cttgtcgaac
     8221 ttttaatgga tacttcaaaa agtaattacg gatggttgtt tgacgacgat tatcaaggat
     8281 agttatgagt tcgtttgtct cataattctg agctacaaaa gccaactcac ctttcttgaa
     8341 accaacttca tcccagaaca taacccttgg gagtctgtca taatgttcct tgaaagtaaa
     8401 ctggtcaagt ttacgataga cagtggacgt cgacacacga agtcttctgg caatatcagt
     8461 tagtgatacc ttctcagtta ggcgttgtgc aactttttgt cggacaagat ttgagatttg
     8521 gcagtttttc tcaacgattg atgtctcagc caccattact ctcttacacc ctttacactg
     8581 gaaacgacgc ttcttaagac gtagtagtgt tggagttcca gcttgctcga gaagaggaat
     8641 tttagaaggt ctttgaaagt cgtatttgat catctttcct tggcaatgag ggcatgatgg
     8701 tgcaggataa ttgcgttttg cttgactctc gatatgagta ttagtttcaa aaacaagaaa
     8761 aataatgata tttgggtctt taattccgat taattctgtg gtattcttaa taagtctcat
     8821 aagttcttcc taatgatggt ttggtcgctt ttcattatag ttctttatgg gactttttgt
     8881 gtacactcaa aaagctctat aatctctaaa gagtaattgc tcattataga gattatagag
     8941 cctgagtttt tttgttgtac tatattttac attttatctt atgaaagaaa ttaaaaataa
     9001 ttttaggttt tcttaatatt atctttaaga taagcacata caatggaatt gtaacaaagg
     9061 aagatacaac aactacaaga aaggaataca taataatgaa aaatactact aacgaaatgc
     9121 tggagttaat ccaagaagtc agtcttgatg aactcgatca agttattggt ggcatgggta
     9181 aaggtactgt tggtactatc tctcatgaat gccgttacaa ttcatgggca ttcttagcca
     9241 cttgttgttc ataatttaaa atcgagagaa ggtaactctt atgaaacaat cagatgaaat
     9301 gttggaatta atccaagaag tcagtcttga tgaactcgat caagttatcg gtggtgcagg
     9361 taatggtgtc attcgtacta ttacacaagg atgtcgcatg cctaataata tgcaagttct
     9421 ttttacatgc tgatcataaa attttgtcaa attatagaag gaaggtagtc taatgaaaca
     9481 atcaaacgaa atgctggaat taatccaaga agtcagtctt gatgaactcg atcaagttat
     9541 cggtggtatg ggtaaaggtg ccgttggtac tatctctcat gaatgccgtt acaactcatg
     9601 ggcattctta gccacttgtt gctcataatt taaaataagt agcttgtctt cgttgttaca
     9661 taaaaagagg ggaacctctt tttttattgt gcttttaaga ttcggaatta actttaactt
     9721 tagtttctct taatcttttc tttaagtgac caatttacaa tagatatgta aacaaaatag
     9781 tttatcagtg atactctaga tttattagtg aggtaaaaaa catgaaaaaa ggaacacaac
     9841 tgtatttgga agcacttgaa gcattgcaag aaattaaagt tgaggaatta gataccttta
     9901 tcggtggggg cggtcgtgct tccaacacta tttcctccga ttgtcgttgg aatagtttac
     9961 aggctatttt tagctgttgt tagttacaaa ggagtaagtc atggatcaaa aagaattatt
    10021 gtatagtcag tttgacgttt ttaataaaca agtcattgaa agatatcttc cagaagtatt
    10081 ggacgagagt gatgatatca ttcaagacat tgaagagcaa atctcggact actaccgttc
    10141 aacattaatc tacttaatta atgaaaaacg cattgacggg agcctaattg gcagttctcc
    10201 agaatcacgt tataactact ttaccaatgt tctatgtcag caaggtatga ttcttgacga
    10261 aattgaagaa cgattcccaa caatcaccca gcgtgtcgtc attagtctta agaaatattt
    10321 agaactaagc aaatacgtaa aagaggcatt tacagcagat ttctctgagt tgctagctga
    10381 aggatatctt gacggtgtag cgtcagatat tagtagtgat gatgtcaaaa ttaaaataac
    10441 tggggatatt cataatggca acggtgtttg tattgttgct tatcaaggga aaaaagtggt
    10501 ttttaaaaag aaatcatctc agccaaatca attattgcaa actttggagc gtgaagttag
    10561 tcagtatttg gataaagaag tttattttat ctctccattt ttggataagg gagagtattt
    10621 ttgggaaaag tttgtatcca gtaaaccatt gttatccgaa gaagaagcta aggagtttta
    10681 ctgtagagta gggtatctat tagcctgtgc ttatatgctt aatatttcag atttgcattt
    10741 tgaaaatttg atatcttccc atataaatcc tatattggtt gatgtggaga ctgttttctc
    10801 aactagtacc tttgatacga ttgcaaacaa tgatgctacc tttaagatca tagaaagcag
    10861 tagagattct gtactattta caggcctact tcccgtatct gaagcagaca aagtttttgg
    10921 aggagacacc agtggtgttt taggtggcat tatgattggt gaagcaagga ttgtaatcaa
    10981 tcataatcgc gatgatattc gtattgaaaa gcaaaagtat aaaacggaaa atcaagacca
    11041 cctcccttac tttagcgata gtgaaggcgt caagacttat ctcaatgcag aggactatgt
    11101 ggactttatt aaatctggat tttcagagct cagtgagttc tttatgcatc gtaaagagtt
    11161 cttaaaaact ctttactcag aatatggtca tcttcaaaca cggcttttat ttagaaatac
    11221 aagagattat agtttaattc gacagttgct gacctctcct gtttattgtg aacaatccca
    11281 cgttttattc gaaaaaatgg aagataagtt ttctgaagtg gatagtcatg aactgtgtca
    11341 atctgaagaa aagcaattgt taaatatgga tattccatat ttttatgctg agattgccag
    11401 tcgtgacgtt agggatgatg aaggcattgt ttggcagttg acaaggacag ctttaagcca
    11461 agtcattaaa aaattggata atctgagttc tgctgttata aacgaacagc tggatctaat
    11521 cgagttttct attaagactc ccaacgctct atatagcaca gaattgcaag atgcctatcg
    11581 agattttgaa aacaatcagc aaactcaaga tcaagacgtt ctgatatctg gtatcaatga
    11641 gttaaccgat gttattttgg agaatgaaaa gaattcccaa gaagatggca gtaccaattg
    11701 gttgacatta aaggttaccg attatgatgc ctttgagtta gtacctatgg atgattctgt
    11761 ctatgatggt ttggcaggaa tggctatagc tttaagtgag gtttatgact tggttgatga
    11821 catcagacag gaaaaaataa ggctttgttt acagcgtatt ttcacaacat tatcaaactc
    11881 ttatctggag ttgcaaaatc aatcctattt tgtagggaaa ttaggccttt tttctgcctt
    11941 aagcagaatt agccccatta ctggacagga gctgcctgac tttgtcttgg atggagatca
    12001 ggattatctc gtagacttgg atgtttcaac ggcagatttt ctatccagtt tcaccaatga
    12061 agtggtagca ttacgaaata gtgatataaa aataggaaat ctcaatcagg cacttgataa
    12121 gcttgatgag ttgaaaatta tctctgagga tttcatcagc tgggataaat tggaatcaaa
    12181 caatgttagc ttagcacatg gcaacttagg tgttgaagta gctctgctct gtcttgcagg
    12241 caatttagag cgtcctgaag ctttgcagtt gttccgtaaa gctaagagat ttgatgatcg
    12301 gcagcgatta gaaaatggct gggtggataa aagaaattca gataccagtg ctaactggtg
    12361 tcatggctca acaggtgtat tagtagccag attagtgcaa ctccgactgg atgatcgcta
    12421 taaactacta tcgccatctg agcgaacagc tctagaagcc gatttgcagc atgcttcaaa
    12481 gcaaatcatt gaccttggtt ttgatatgac aaacttttct ctctgtcatg gaaccagtgg
    12541 caatttgctt gctctgagct attaccaatc ttacttacca gaaaatgatg ctcaaagatt
    12601 aagggctatc ttggacaagg aatatcgcaa actgcatgcc tttggtttaa caaagggatg
    12661 gatgtgcagc tttaatacaa aatataatgt ctatggtttg atgactggac tgccagggat
    12721 tctttattcc acagcaaaat ttttaaaggg agacgattcg cttgacgttt taatcccaaa
    12781 tctttaagag gtagaaaggt ttatatggta tgaagattat tttgcaaaat aatgaagaag
    12841 actgtctttt agcctgttac acaatgttgc ttaatgattt aggtcataaa gttccattat
    12901 atgaagtgta tgataaagat acattgccgg cagacggtct cagtgtctcc tacctcttat
    12961 cgctaaatga caggtttggt gttactatca atgcttatcg tgcctctttt gatgaattgt
    13021 taaaagtcta tagacagcga aaacaaagga tgattctgca ttggaatcaa gaacattttg
    13081 ttattcttga aaaaatcaca tcaaaacaag tgactattgt tgacccagcg attggacgag
    13141 taaagtatag ccgtgatgag tttttaagtc attattctga aacgatgatt cttgtaaaaa
    13201 ggggggatta tttccagcct caatcgtata aacagatttt ttggaagtat tttagaaaga
    13261 ctctaaagct aaagcccgtt tctttttttc tagtgtcact attattcatt cagacaggtg
    13321 tccttttatt ctcagtagcc ttgaggcaaa tgttggcaga tgatttcaaa ttttgggtta
    13381 gcatgtccct tttggcaata gtacttctct ttcaattaat aggttatttt ataaagaata
    13441 tagccttaga ccgatataac acggactttg atgacaatta cagcaaagcc ttatttcaaa
    13501 aattactaaa aaaaccgctt ctatatttta gaaatcattt gaatggtggt gtctctgaaa
    13561 aaataaattt taaatcaaca cttagggata atgtgacctt gaaaattatc ccgtcatgtg
    13621 tcagttttat ctcagccatt gttgtctttg cttatttaat gacgatatca atcaaattaa
    13681 ccctaatatt aatgacgatg attgccatat atgctgttat ttccatccta ctataccgta
    13741 agcagaatga gcataatcag gcgtatttac aatatttaat tgattttaat tctgagttgc
    13801 agacagacct agatgatata gactatatca aaattatgag gagagaaggg cttacttttg
    13861 gttcatggat gcgtagtaat cagcaggtga caacgaagta ttctcagata ctcaagatag
    13921 aaaatctttc acaaattata gggaccttct ttaactatat cagcttgtct tcgatcattg
    13981 tcattgcggt atattacaaa gtctatatca aagtatcgct tccagacttg ttggtttatc
    14041 aaacgagtat ctccttgttg atatcttcaa ttgagcaagt caaaggtgct gtctttgaaa
    14101 tcacacgatt gggagtatat gctgagaaac aaagtgattt actgaaggac agtaaaccta
    14161 ttaccgtgcc aagttcaggg tccgcggatt atttaatcaa agcagagcat ttgaactttt
    14221 cttatggtgc taagaaagtt tatagcgatg ttaatttaac agttaataaa ggtgaaaaaa
    14281 ttgctattgt agggaaatct gggagcggaa aatctactct cctcttactg ttagcaggta
    14341 tactacgtta tgatggctct cttgaatatg gtgtcaaaaa ttttgaggat tatttgagtg
    14401 tggtgcttca aaatatgacg cctagaaaag gaagcatttt agagaactta gagtggagct
    14461 atgatgatct tgctcctgtt tatcaggtca tgaaagatac atcagctgat gaaattatta
    14521 atcagctgcc aaataaaatt cactcaaaat tgttgaaaca agggaaaaat ctatcaggcg
    14581 gtcaaatcca gaagctgctt atcacgaaat ccttgttgaa agaaaatgcc attatttttt
    14641 gggatgaagc tttcagtaat ctcgatgaac aaagtaaaaa taaaatctat aataatgtgt
    14701 tgcaaaatga caggtattca gaaagaacaa tgctgattat cagccaccat ttagacatcg
    14761 tcaactatgt tgactacatt atttatatag atgctgcaac aggcgatgtg attaaggata
    14821 gtcataacca tctgatgcaa agcaatgaaa actatgccga ttttatcacg tctaaaattt
    14881 aaggttgctt tcaggttttc ttaattttat ctttaagtcg gctgggtata ataacaacag
    14941 tatcaaaaag gagcagtcct aacgaaatac tgaacgataa ccaaaggagt gaaaacatgg
    15001 acaatgttat tgaactacag aatttaacaa aggtatacaa tggtgtgacg acagtagacc
    15061 ttaaaaagat tactgtgcat cagggggaaa tatatggttt tcttgggcca aatggtgctg
    15121 gtaagacaac aacgatgaag atgattttgt cacttattgc accaacttca ggaaacgttt
    15181 tagtgaatga cagtaatatc aagaaagatg tcgcttactt ggatcaaatt ggttccatga
    15241 ttgaagagcc atcttattat cctaacctga ctggttatga aaatctttta gtatttcaaa
    15301 aaatgcttag ttttgataaa aataatattt ggccaacgct ggaacttgtc ggattagcag
    15361 atgagaaaaa cacgaagaaa cttgttaaag cctattccct aggaatgaag caacgcttag
    15421 ctttagcgtt tgcattggtg aaaaggccaa aaatcttact gctggatgaa ccaactaatg
    15481 gtctggatcc tgcaggtatt catgagattc gggagttgat tgtaacactg gcgaaagaga
    15541 aggggctgac agtatttatt tctagccata tcttgtctga gattgagcat attgcagatc
    15601 gtgtgggcat tattaaccac ggtcgtctcg tctatgaggg agcgattgaa gcgattcagt
    15661 ccaatgcttg gattgagatt ggcggcgatt tttcaacagg cgatatcacg acagctctaa
    15721 atgaatatgg attagttagg gttcttgata tagcagccaa taaattaacc ttagacgatt
    15781 tttccaataa cgacttagca gactttgtca cctatttggt agaaaaaggc tttcgcattt
    15841 ttagagttgt tcgtgagaca gagactcttg aagacatttt ccttaattta acaacggagg
    15901 tttgagatga caaaagcaat taaagttgaa tggctgaaaa gcaagcgaac aaaatctctg
    15961 accgtttcta ctcttattat tcttattggg gtattttggt caattcttgg aacagtaatg
    16021 caaaaatcat cgtctggttg ggaaatgttt tttgataatc aagatgccct tcccatgttt
    16081 ctgccactag ctattagtat ttttgtttca cgtattataa gtaatgaaaa agaaggcaga
    16141 acctttaaat tacaagcaag taatgcccat gggatacttg aaatattcca caataaatta
    16201 tggtttacaa gtttattctt tttctctatg gcagtggtat atacttcgat aatttcattt
    16261 tatgttacct ttatcaaagg agaatcaatt tctggccttg cgcccgtcca tcagatagtg
    16321 acgtttacct taggaagctt tgtacaaatt tgcctttata tagttatggc aatgataatg
    16381 gaaaaacaaa gtgccgtgtt ggcaactgga tttctcgggg cttttgtggg tatagtattt
    16441 caacgtcttt caatgaaatt ctggtctttt ttcattcctt ggttaggaac aagtttctta
    16501 gcaatgtatc actttggtta tgatgataaa acagaaacgg cgttcgctac tttggataat
    16561 caaatattct taaagctcat tgtatatagc atgtatgctg tactgtgcta tctagcagcg
    16621 agatatattg tttcgcataa aggaggagaa ctgttataat gaagtattta tcttctgaat
    16681 ggcttaaatt acgtaaactc cagcttttac tagtaggtct tatcttgctt tcaataggaa
    16741 gttttgttgg actaggaacc tattatgcca atagacaagt ctttattcat gacactcagt
    16801 ctcgggtcat gtggggacaa ttaacgtttt atcatagcca ggtcttctac cctgctttac
    16861 ttgccatctt tgtggggatt agtttaatgc cagagtttga gagaatgacc tttgaaatgt
    16921 tgaaggctaa taatgtatca ataggcaagc tattgatgag caaattactt actttaacgt
    16981 tcactttagt tccctttcag tttttgctgg ttgtgatttg gtgggttggc ttgaaacttg
    17041 ataatattag tgttacttca gaaatagggg ttcatataaa atgggtatta ttatcgttga
    17101 ttgggtcgct tagtatttta agtctgcagt ccttcattct agttaaaacc aaaagttttg
    17161 ccaaatcagt tggcttttct gctatggggg taatggttgg ttttgtactc atgctggttt
    17221 ttgaaccgct cagtcatatc tttccttatt cacaaccaat gatagggtta cgtgctagag
    17281 ccttagcaga tatgtcattt tcggagtttg ttatctttat agtggtaaat gtcttctata
    17341 cattgctttt ttacaaactg acacagcgga cactggagaa aaaagggtag agaatcaaag
    17401 attagaaaat tcagagttta gggacaaaag cggaaataga atcggtaact tcttggaatc
    17461 tcggttccac caagaaaatt agcattgaac gtgcccgttt ggaagaggat gttgggaaaa
    17521 catcctcgct gctgctgatt attctatgat tcctatgtgg agctcaactg tcaaagcgtg
    17581 cctttaaccg aaatcgtttc tgaagctgaa agacgaataa aactaaggtt cataaatcgt
    17641 cttacaagga aaagtacagc aatcgctatt ctttctctgc gaggcgtttt ttatttccaa
    17701 aaatagaaaa ctaacaggcc atttccaaat aggtgaaaat aatcctgatg gaatcatgct
    17761 agcatgacaa ctacgcaaaa aacgtattta catattattc gtgaactgga aaatcaagat
    17821 attgatttga ttatgcgttc attaacaagt ctgacttaaa ataaaaacgc tgatgaagct
    17881 taaaccatca gggtgctggt tttttgatag aaaattatgc taaaataaag aaaaatgtat
    17941 tttgggagta agtatgaaga aatcgtttaa gggaacgatt cttgttgttc tagcagccat
    18001 tgcttggggc atatcaggag tgtcgggcca atttttaatg aagcagggca tttctgtcta
    18061 tttattgact tccttgcgtt tattgatatc agggctactt ttaattggag ttgtcatttg
    18121 gcaacagcct cagcagatca aagctattct agaggataaa aaggtgttag cagggatttt
    18181 tggttttagt atttgcgggc ttcttctcaa tcagtttagt tatttgcagg ctattcatta
    18241 taccaatgct ggaacggcaa ctgtcctaca atatatggca cctgttttag ttctgactgt
    18301 tatctgtttt agggaccgta gtttgccaac aatgggtgaa ctgactgcta ttcttttagc
    18361 tattttgggg acatttgtca tagcaacgta tggacagatg ggcaatctcg ctctgtctcc
    18421 agttggtctt ttttggggtc tcttttctgc tgtgacttat actctttata tgcttttgcc
    18481 cattaaactc attcaagaat ggggcagtct cttagttatt ggattgggta tgctgctggg
    18541 aggtctggta tttagtcttg tctctcagtc ttggcaatac aatcctcaat ttcaggcaaa
    18601 taacctgttg gcttatgttg gtttaatcat tgttggcagt gtttttgctt acacttcttt
    18661 tttgaaggga gtcagtctga ttggtgctgt aaaaggcagc cttctggctt ctattgaacc
    18721 aatcgcagca gtcttttttt cagttactct tatgaaagaa attttttacc ccatcgattt
    18781 cctaggcatg ctgttgatta tactagccgt tcttatcatt tctatcaaag acttattagc
    18841 aaccaataaa gaaaaagtct gagttccatc tcagattttt tgctctattt gattaaggtt
    18901 tggtttgtaa atctttgata atagtttgag ctattagggt atttccgcca gcagtttggg
    18961 caatcttttg aaaatgcaag atagtatttt tgtaagaaga atctttaaga attgtatggg
    19021 ctgcttgttt gattttttga ggatttaagt tgtgacgttt aaggtatttt cctaaatgta
    19081 aatcagcaac ttgctgggcg actcgaggct gatcattgcc aacaggaatc actagcatag
    19141 ggcagccata atagatagct tcattaacac tgttcatgcc accatgagta agaaaaagtg
    19201 aagctctttc caagatttgg agttgaggaa cgaaagaata aagatgaaca ttggctggca
    19261 ttgttcctag ttgttctttt ttaatcctat ttccaagtga aataatgata gagtagggct
    19321 cattttcaaa agccttgata cattttttaa aaaaggagac agagcgattg aggagagtac
    19381 ctaatgaaat ataaataatc ggatttttaa aaggtgtgaa atcaaaaggt ggctcgacag
    19441 gacgattgat ggaaggccca acgtattgat agtgattttc atcaaacgta tcagcatcaa
    19501 tttgaaattc ccgtactgta tacgtgaaat tgagttcggg agtattaaga ctgatttcct
    19561 tagcaagatc atcataagcc agctgaaagg ttctttgcaa ttttcttgat aaaagatggc
    19621 gcagaaaagt gaagcgaaaa atactggtca gataaaagcc acctgttttc ccaaattctg
    19681 acagaatttt ttcatttaag gaaaaagttg agaatagccg ataagctgga atattcagtc
    19741 tgtccgccag agcttttcct ggaaagaata gcatttcata aagcaaacaa tcgtaatctt
    19801 tacccatacg taagacagtc tgataggcag ctgaccagct tttaacgttc ttttgccttt
    19861 ctgataacga atctggataa tggtcataag gaacaaaatg tgcacccgtt ctttcaatct
    19921 tactttgcca atcaggggca ttaatatagg tgacattatg acctagctgg actaaaattt
    19981 gagcaagttc caaagtcgga ttggtatggc cggaaaaagg aagattaacc attaaaatgt
    20041 tatagtgtgt ttttttcatc atagtgtttt aatccatttt taagtttgtt tttatcgttt
    20101 tcatctaaaa gaggaaggcc gaatttttcc agtaaaagtg cgataaaatc aatcctttgg
    20161 caagctgtct gataatcaaa gtcaacaata gaaggatcca gccaaatatc aaacagtaaa
    20221 acaaggattt ctgaaagttc tttagagtac tgacagttaa gctttttttc ttttatttcc
    20281 tgctggatga tagcttcaat gtattgggca accaccgtta gagaattttt taacgtttct
    20341 aaaagggcaa aagggatttt ctcagcccaa tgaagtctgg ttaaccctgt taatgaagga
    20401 ttttcaaaaa aataagttag aatcccctta aatttttgtt gggcatttaa ctgattattg
    20461 ctgatgagag catctagaca ttgccttaga ttgtccattt ccagactgat ttgaaaattt
    20521 agaatctctt gcttactgga aaaatgatga tagatagcgc cttttgaacg tccgctcttg
    20581 tggacaattt cccgcattgt tgtctcttca taaccctttt gcaagaataa tgtcatcgct
    20641 gtttgggcaa ttctcttttt agataattgc gtttttgctt cttgtttcaa cgtgtagtcc
    20701 cttctttttc ataaaacaga ccaatagtct gttttttaga ttatagtaac gctttagatt
    20761 ggaaatgtca agaagatgat atttctatat actccaatag agaatgttgg tagcaatgtt
    20821 ttttagtata aatattagat aaaagtaagc gaagtgagca tcaaaagaga aaaaatacgg
    20881 gtttgatgat acctttttct tcctcgcctt attctttatt ttatgttaaa ataaaaggta
    20941 atattttatt tggagaaata agtgagtatc gaaaattatc gacccgattt cgtggtagaa
    21001 gccgtttatg atttaacccc tgatagcctg cgaaagcacg gtattaaagc cgttcttgtc
    21061 gatttggaca ataccttaat tgcttggaat catcctgatg gcacacccca gttgcgggat
    21121 tggctggata gtatgactga agcagatatg ccggtagtcg tggtatctaa caatagttat
    21181 acacgtgtca aacgggctgt caaaggtttt catgtagatt ttgtcagtcg ggctctgaaa
    21241 cctttttctc gcggtattaa tatagcagtg aatcgctatg gcttttctaa agatgaagtt
    21301 gttatggtgg gcgatcagct aatgacggat attcgtgcgg ctcaccgtgc tggtgttaaa
    21361 agtattttgg ttaaaccttt agttaagtca gatgcttgga atactaagtt taaccgtgcg
    21421 cgtgagcgtc gtgtttggaa aaaaatagaa gacaaatatg gtgcttttgt ctataaaaag
    21481 gaaatttaag tggaagaatt attttgtatc ggctgtggag cgcaaattca aacgacagcc
    21541 aaagagcaag ctggctatac accaaagtca gccttggaaa aaggacttga aagcgggaaa
    21601 atatactgcc aacgctgttt tagactgcgt cattataacg aaatcacaga tgtgcatatt
    21661 tcagatgatg attttttaaa gcttctccat gaagtggggg acagcagggc tcttgttgtt
    21721 aatgtgattg atatttttga ttttaatggc tccgttatac cgggattgca gcgttttatc
    21781 tctagcagtg atttgctttt agtgggaaat aaagcggaca ttctccccaa atcagtcaaa
    21841 tctgggaaaa taacacagtg gctgatggag cgtgcgcatg aagaaggatt gcggccgctt
    21901 gatcttatct taaccagtgc ccagaataaa tgggcgataa aagaattaat tgctaagatt
    21961 gaagaacttc gtcagggacg ggatgtctat gttgttggtg ttactaatgt tgggaaatca
    22021 actcttatca atgccattat tcaggaaatc actggtgata aaaatattat cacaacatcg
    22081 cgttttccgg gaacgaccct agataagatt gaaattcctc tgaatgatgg ttcctatatt
    22141 tttgatacgc cggggattat ccaccgtcat cagatggctc attacttatc agacaaggct
    22201 ctcaagtata tcagtcctaa aaaagaaatc aagcctaaaa cttaccagct caatcctgaa
    22261 cagacgctct ttttaggcgg tttggctcgt tttgattatg taacgggcga taagcaaggc
    22321 tttacagctt attttgataa taatctcaaa ttacacagaa ctaagttggc tggagcggat
    22381 gctttctatg acaaacatat cggcagcctt ttgacgccgc cagataagaa ggaaatggca
    22441 gcctttccca aattggtaag gcatgaattt acgataaaag aaaagacaga tcttgttttt
    22501 tcaggtttgg gttggattcg catcaatggc agagccaaaa ttgctgcttg ggcacctgaa
    22561 ggggttgctg ttgtgacaag aaaagcctta atttgactta tctagatgtt aggcttataa
    22621 ccctgccatt ttaacaaaaa ggaataaaaa atatgcttac aagtaaacag cgtgcctttt
    22681 taaaatcgga ggcacattct ctgaaaccca ttgtgcagat tgggaaaaat ggtctcaacg
    22741 accaaatcaa aaccagcgtt agaaacgctc ttgatgcacg tgaattg
//
