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Overview
1.1
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1.7
1.8
1.9

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP023477.1 (Streptococcus mutans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | RiPP-like | 284,416 | 294,993 |
Region 2 | lanthipeptide-class-ii | 351,020 | 373,806 | Medium | macedocin | ribosomal:RiPP:Lanthipeptide
Region 3 | RaS-RiPP,RRE-containing | 625,900 | 648,398 | High | tryglysin B | ribosomal:RiPP
Region 4 | T3PKS | 1,105,885 | 1,147,060 |
Region 5 | lanthipeptide-class-i | 1,400,312 | 1,424,545 | High | mutacin III | ribosomal:RiPP:Lanthipeptide
Region 6 | terpene-precursor | 1,473,054 | 1,493,923 |
Region 7 | RiPP-like | 1,631,886 | 1,642,116 |
Region 8 | NRPS,T1PKS,RiPP-like | 1,744,887 | 1,814,746 |
Region 9 | HR-T2PKS,butyrolactone | 1,900,586 | 1,942,679 |

NZ_CP023477.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 284,416 - 294,993 nt. (total: 10,578 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000503.5 |  | 0.21 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002300.2 |  | 0.19 | NRPS | albomycin delta2, albomycin delta1, albomycin epsilon | Streptomyces sp. ATCC 700974
BGC0001283.3 |  | 0.18 | PKS | Bisenarsan | Streptomyces lividans 1326

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000503.5 |  | 0.21 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002300.2 |  | 0.19 | NRPS | albomycin delta2, albomycin delta1, albomycin epsilon | Streptomyces sp. ATCC 700974
BGC0001283.3 |  | 0.18 | PKS | Bisenarsan | Streptomyces lividans 1326

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.99 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.05 out of 18.16
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.35 out of 20.97
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.00 out of 24.78
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.91 out of 29.25
Confidence: medium
Additional weak hits (4):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.50 out of 36.53
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.15 out of 29.25
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 30.11
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.42 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization

NZ_CP023477.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 351,020 - 373,806 nt. (total: 22,787 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: glycosyltransferase
CO204_RS01930: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

Lyases: cyclase
CO204_RS01895: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000534.3 |  | 0.94 | ribosomal | mutacin K8 | Streptococcus mutans
BGC0000557.5 |  | 0.68 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0001788.3 |  | 0.67 | ribosomal | suicin 65 | Streptococcus suis
BGC0000550.3 |  | 0.66 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000547.5 |  | 0.65 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000526.5 |  | 0.62 | ribosomal | macedocin | Streptococcus macedonicus
BGC0000521.3 |  | 0.60 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000539.5 |  | 0.59 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000532.3 |  | 0.57 | ribosomal | mutacin II | Streptococcus mutans
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000534.3 |  | 0.94 | ribosomal | mutacin K8 | Streptococcus mutans
BGC0000557.5 |  | 0.68 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0001788.3 |  | 0.67 | ribosomal | suicin 65 | Streptococcus suis
BGC0000550.3 |  | 0.66 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000547.5 |  | 0.65 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000526.5 |  | 0.62 | ribosomal | macedocin | Streptococcus macedonicus
BGC0000521.3 |  | 0.60 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000539.5 |  | 0.59 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000532.3 |  | 0.57 | ribosomal | mutacin II | Streptococcus mutans
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for CO204_RS01895

CO204_RS01875
Leader:
MKNTTNEMLELIQEVSLDELDQVIGG
Core:
M G K G T V G T I S H E C R Y N S W A F L A T C C S
Core with dehydrations:
M G K G Dhb V G Dhb I Dha H E Cys R Y N Dha W A F L A Dhb Cys Cys Dha

#### antiSMASH-DB 4.0 matches for CO204_RS01875

100.0%
NZ_CP023477.1:
Lanthipeptides: CO204_RS01875_lanthipeptide
1
M G K G T V G T I S H E C R Y N S W A F L A T C C S
26
M G K G T V G T I S H E C R Y N S W A F L A T C C S
1
M G K G T V G T I S H E C R Y N S W A F L A T C C S
26
96.2%
NC_013928.1 and 8 others:
NC_013928.1 Lanthipeptides: SMUNN2025_RS01700_lanthipeptide NZ_CP023477.1 Lanthipeptides: CO204_RS01885_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01090_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01080_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01745_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01735_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07575_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07565_lanthipeptide
Lanthipeptides: SMUNN2025_RS01710_lanthipeptide
1
M G K G T V G T I S H E C R Y N S W A F L A T C C S
26
M G K G V G T I S H E C R Y N S W A F L A T C C S
1
M G K G A V G T I S H E C R Y N S W A F L A T C C S
26
69.2%
NZ_CP018188.1 and 17 others:
NZ_CP018188.1 Lanthipeptides: BSR19_RS11175_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07300_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07295_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09705_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09700_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05120_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05115_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04335_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04330_lanthipeptide
Lanthipeptides: BSR19_RS11180_lanthipeptide
2
G K G T V G T I S H E C R Y N S W A F L A T C C S
26
G G T I S H E C N+W A F L A T C C S
1
G N G V F K T I S H E C H L N T W A F L A T C C S
25
with 61 more sequence matches
Only the first 10 are displayed here.
69.2%
NZ_VDNV01000006.1:
Lanthipeptides: FSV44_RS08765_lanthipeptide
2
G K G T V G T I S H E C R Y N S W A F L A T C C S
26
G G + T I S H E C R N S W F L T C C S
1
G G G V I Q T I S H E C R M N S W Q F L F T C C S
25
65.4%
NZ_ALSD01000046.1 and 49 others:
NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08890_lanthipeptide NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02935_lanthipeptide NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08685_lanthipeptide NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08680_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05700_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08730_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08725_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08980_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08975_lanthipeptide NZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01070_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09265_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09260_lanthipeptide NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08765_lanthipeptide NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08760_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08915_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08910_lanthipeptide NZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02170_lanthipeptide NZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09655_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03455_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03450_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08825_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08820_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03170_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02470_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08470_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08465_lanthipeptide NZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09580_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09035_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09030_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08495_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08490_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08505_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08500_lanthipeptide NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06790_lanthipeptide NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06785_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS04310_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS04305_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02595_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02590_lanthipeptide NZ_CP035428.1 Lanthipeptides: ETT71_RS02815_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06680_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06675_lanthipeptide NZ_CP035443.1 Lanthipeptides: ETT56_RS07265_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS105315_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03145_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03140_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06755_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06750_lanthipeptide NZ_LT545678.1 Lanthipeptides: BJR96_RS07040_lanthipeptide
Lanthipeptides: SAG0161_RS120605_lanthipeptide
3
K G T V G T I S H E C R Y N S W A F L A T C C S
26
G T I S H E C N+W A F L A T C C S
3
N G V F K T I S H E C H L N T W A F L A T C C S
26
65.4%
NZ_CP026729.1:
Lanthipeptides: BKKJ1_RS07010_lanthipeptide
2
G K G T V G T I S H E C R Y N S W A F L A T C C
25
G G V T I S H E C N S W F L T C C
1
G N G V V T T I S H E C N M N S W Q F L F T C C
24
65.4%
NZ_GL985606.1:
Lanthipeptides: HMPREF9062_RS00700_lanthipeptide
2
G K G T V G T I S H E C R Y N S W A F L A T C C
25
G G T I S H E C Y N S W A F+ T C C
1
G N G V F H T I S H E C Y Y N S W A F I F T C C
24
61.5%
NC_012470.1 and 2 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide
Lanthipeptides: SZO_RS04065_lanthipeptide
4
G T V G T I S H E C R Y N S W A F L A T C C S
26
G + T I S H E C N S W F L T C C S
4
G A I K T I S H E C H M N S W Q F L F T C C S
26
61.5%
NC_012470.1 and 11 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide
Lanthipeptides: SZO_RS04070_lanthipeptide
4
G T V G T I S H E C R Y N S W A F L A T C C S
26
G T I S H E C N S W F L T C C S
4
G V F K T I S H E C H M N S W Q F L F T C C S
26
61.5%
NZ_CAAHKQ010000003.1:
Lanthipeptides: E9664_RS02165_lanthipeptide
3
K G T V G T I S H E C R Y N S W A F L A T C C S
26
G T I S H E C N+W A F L A C C S
3
N G V F K T I S H E C H L N T W A F L A I C C S
26
61.5%
NZ_CP023483.1:
Lanthipeptides: CNY62_RS11970_lanthipeptide
2
G K G T V G T I S H E C R Y N S W A F L A T C C S
26
G G + T I S H E C N+W F L T C C S
1
G N G A I R T I S H E C H M N T W Q F L F T C C S
25
61.5%
NZ_CP060646.1:
Lanthipeptides: H7789_RS06845_lanthipeptide
3
K G T V G T I S H E C R Y N S W A F L A T C C S
26
G T I S H E C N+W A L A T C C S
3
N G V F K T I S H E C H L N T W A S L A T C C S
26
61.5%
NZ_MSRJ01000005.1:
Lanthipeptides: BKH06_RS03755_lanthipeptide
3
K G T V G T I S H E C R Y N S W A F L A T C C S
26
+G V T I S H E C N S W F+ T C C S
1
E G V V T T I S H E C N M N S W Q F I F T C C S
24

#### MIBiG 4.0 matches for CO204_RS01875

17.9%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
2
G K G T V G T I S H E C
13
K G T++ E C
12
N K G A Y C T L T V E C
23
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
8
T I S H E C R Y N
16
T+S E C+ N
29
T L S K E C Q P N
37
CO204_RS01880
Leader:
MKQSDEMLELIQEVSLDELDQVIGG
Core:
A G N G V I R T I T Q G C R M P N N M Q V L F T C
Core with dehydrations:
A G N G V I R Dhb I Dhb Q G Cys R M P N N M Q V L F Dhb Cys

#### antiSMASH-DB 4.0 matches for CO204_RS01880

100.0%
NC_013928.1 and 4 others:
NZ_CP023477.1 Lanthipeptides: CO204_RS01880_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01085_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01740_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07570_lanthipeptide
Lanthipeptides: SMUNN2025_RS01705_lanthipeptide
1
A G N G V I R T I T Q G C R M P N N M Q V L F T C
25
A G N G V I R T I T Q G C R M P N N M Q V L F T C
1
A G N G V I R T I T Q G C R M P N N M Q V L F T C
25
60.0%
NZ_CP023483.1:
Lanthipeptides: CNY62_RS11970_lanthipeptide
2
G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G N G I R T I+ C M N Q L F T C
1
G N G A I R T I S H E C H M-N T W Q F L F T C
23
60.0%
NZ_VDNV01000006.1:
Lanthipeptides: FSV44_RS08765_lanthipeptide
2
G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G G V I+T I+ C R M N+ Q L F T C
1
G G G V I Q T I S H E C R M-N S W Q F L F T C
23
with 45 more sequence matches
Only the first 10 are displayed here.
56.0%
NZ_CP026729.1:
Lanthipeptides: BKKJ1_RS07010_lanthipeptide
2
G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G N G V+ T I+ C M N+ Q L F T C
1
G N G V V T T I S H E C N M-N S W Q F L F T C
23
56.0%
NZ_CP084014.1 and 6 others:
NZ_CP084014.1 Lanthipeptides: LCQ72_RS00100_lanthipeptide NZ_CP084014.1 Lanthipeptides: LCQ72_RS00095_lanthipeptide NZ_CP094679.1 Lanthipeptides: K5I24_RS13105_lanthipeptide NZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12415_lanthipeptide NZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12410_lanthipeptide NZ_JAQEYW010000015.1 Lanthipeptides: PG422_RS12405_lanthipeptide
Lanthipeptides: LCQ72_RS00105_lanthipeptide
2
G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G N G V++T I+ C M N Q L F T C
1
G N G V L K T I S H E C N M-N T W Q F L F T C
23
56.0%
NZ_JAEEGA010000010.1:
Lanthipeptides: I6N95_RS15660_lanthipeptide
2
G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G N G V I+T I+ C M N+ Q +F T C
1
G N G V I K T I S H E C H M-N S W Q W I F T C
23
56.0%
NZ_LT732526.1 and 1 other:
NZ_LT732526.1 Lanthipeptides: BQ9856_RS23075_lanthipeptide
Lanthipeptides: BQ9856_RS23080_lanthipeptide
2
G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G N G V I+T I+ C M N Q +F T C
1
G N G V I K T I S H E C A M-N T W Q F I F T C
23
52.0%
NZ_JH792236.1 and 1 other:
NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide
Lanthipeptides: IIM_RS26245_lanthipeptide
2
G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G+G V I+T I+ C M N+ Q +F T C
1
G S G V I K T I S H E C H M-N S W Q A I F T C
23
52.0%
NZ_QTVL01000002.1 and 5 others:
NZ_QTVL01000002.1 Lanthipeptides: DWZ44_RS04150_lanthipeptide NZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14340_lanthipeptide NZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14335_lanthipeptide NZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02940_lanthipeptide NZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02935_lanthipeptide
Lanthipeptides: DWZ44_RS04155_lanthipeptide
2
G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G+G V R T I+ C M N Q +F T C
1
G D G V F R T I S H E C N M-N T W Q F I F T C
23
50.0%
NC_012470.1 and 2 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide
Lanthipeptides: SZO_RS04065_lanthipeptide
3
N G V I R T I T Q G C R M P N N M Q V L F T C
25
N G I+T I+ C M N+ Q L F T C
3
N G A I K T I S H E C H M-N S W Q F L F T C
24
50.0%
NC_012470.1 and 11 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide
Lanthipeptides: SZO_RS04070_lanthipeptide
3
N G V I R T I T Q G C R M P N N M Q V L F T C
25
N G V +T I+ C M N+ Q L F T C
3
N G V F K T I S H E C H M-N S W Q F L F T C
24
50.0%
NZ_MSRU01000008.1:
Lanthipeptides: BKH03_RS04355_lanthipeptide
1
A G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G+G V +I T C M N++Q V L T C
1
G G D G V K W S I T H E C Y M-N S L Q V L L T C
24
48.1%
NZ_CP069183.1:
Lanthipeptides: LLNCDO700_RS13730_lanthipeptide
1
A G N G V I R T I T Q G C R M P N N M Q V L F T C
25
G+G V I T I+ C M N+ Q +F T C
2
G G S G V I H T I S H E C N M-N S W Q F V F T C
25

#### MIBiG 4.0 matches for CO204_RS01880

23.3%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
3
N G V I R T I T Q G C R M P N
17
N G T+T+ C+ P N
15
N G G W C T L T K E C Q-P N
28
21.4%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
4
G V I R T I T Q G C R M P N
17
G T+T C M P+
14
G A Y C T L T V E C-M P S
26
CO204_RS01885
Leader:
MKQSNEMLELIQEVSLDELDQVIGG
Core:
M G K G A V G T I S H E C R Y N S W A F L A T C C S
Core with dehydrations:
M G K G A V G Dhb I Dha H E Cys R Y N Dha W A F L A Dhb Cys Cys Dha

#### antiSMASH-DB 4.0 matches for CO204_RS01885

100.0%
NC_013928.1 and 8 others:
NC_013928.1 Lanthipeptides: SMUNN2025_RS01700_lanthipeptide NZ_CP023477.1 Lanthipeptides: CO204_RS01885_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01090_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01080_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01745_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01735_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07575_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07565_lanthipeptide
Lanthipeptides: SMUNN2025_RS01710_lanthipeptide
1
M G K G A V G T I S H E C R Y N S W A F L A T C C S
26
M G K G A V G T I S H E C R Y N S W A F L A T C C S
1
M G K G A V G T I S H E C R Y N S W A F L A T C C S
26
96.2%
NZ_CP023477.1:
Lanthipeptides: CO204_RS01875_lanthipeptide
1
M G K G A V G T I S H E C R Y N S W A F L A T C C S
26
M G K G V G T I S H E C R Y N S W A F L A T C C S
1
M G K G T V G T I S H E C R Y N S W A F L A T C C S
26
69.2%
NZ_CP018188.1 and 17 others:
NZ_CP018188.1 Lanthipeptides: BSR19_RS11175_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07300_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07295_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09705_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09700_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09300_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09295_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06585_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06580_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05120_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS05115_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04335_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04330_lanthipeptide
Lanthipeptides: BSR19_RS11180_lanthipeptide
2
G K G A V G T I S H E C R Y N S W A F L A T C C S
26
G G T I S H E C N+W A F L A T C C S
1
G N G V F K T I S H E C H L N T W A F L A T C C S
25
with 67 more sequence matches
Only the first 10 are displayed here.
69.2%
NZ_VDNV01000006.1:
Lanthipeptides: FSV44_RS08765_lanthipeptide
2
G K G A V G T I S H E C R Y N S W A F L A T C C S
26
G G + T I S H E C R N S W F L T C C S
1
G G G V I Q T I S H E C R M N S W Q F L F T C C S
25
65.4%
NC_012470.1 and 2 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06490_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09840_lanthipeptide
Lanthipeptides: SZO_RS04065_lanthipeptide
4
G A V G T I S H E C R Y N S W A F L A T C C S
26
G A+ T I S H E C N S W F L T C C S
4
G A I K T I S H E C H M N S W Q F L F T C C S
26
65.4%
NZ_ALSD01000046.1 and 49 others:
NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08890_lanthipeptide NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02935_lanthipeptide NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08685_lanthipeptide NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08680_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05700_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08730_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08725_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08980_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08975_lanthipeptide NZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01070_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09265_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09260_lanthipeptide NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08765_lanthipeptide NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08760_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08915_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08910_lanthipeptide NZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02170_lanthipeptide NZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09655_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03455_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03450_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08825_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08820_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03170_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02470_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08470_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08465_lanthipeptide NZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09580_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09035_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09030_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08495_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08490_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08505_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08500_lanthipeptide NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06790_lanthipeptide NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06785_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS04310_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS04305_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02595_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02590_lanthipeptide NZ_CP035428.1 Lanthipeptides: ETT71_RS02815_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06680_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06675_lanthipeptide NZ_CP035443.1 Lanthipeptides: ETT56_RS07265_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS105315_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03145_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03140_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06755_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06750_lanthipeptide NZ_LT545678.1 Lanthipeptides: BJR96_RS07040_lanthipeptide
Lanthipeptides: SAG0161_RS120605_lanthipeptide
3
K G A V G T I S H E C R Y N S W A F L A T C C S
26
G T I S H E C N+W A F L A T C C S
3
N G V F K T I S H E C H L N T W A F L A T C C S
26
65.4%
NZ_CP023483.1:
Lanthipeptides: CNY62_RS11970_lanthipeptide
2
G K G A V G T I S H E C R Y N S W A F L A T C C S
26
G G A+ T I S H E C N+W F L T C C S
1
G N G A I R T I S H E C H M N T W Q F L F T C C S
25
65.4%
NZ_CP026729.1:
Lanthipeptides: BKKJ1_RS07010_lanthipeptide
2
G K G A V G T I S H E C R Y N S W A F L A T C C
25
G G V T I S H E C N S W F L T C C
1
G N G V V T T I S H E C N M N S W Q F L F T C C
24
65.4%
NZ_GL985606.1:
Lanthipeptides: HMPREF9062_RS00700_lanthipeptide
2
G K G A V G T I S H E C R Y N S W A F L A T C C
25
G G T I S H E C Y N S W A F+ T C C
1
G N G V F H T I S H E C Y Y N S W A F I F T C C
24
61.5%
NC_012470.1 and 11 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS06485_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05185_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05180_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09835_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09830_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05350_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05345_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05065_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05060_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05580_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05575_lanthipeptide
Lanthipeptides: SZO_RS04070_lanthipeptide
4
G A V G T I S H E C R Y N S W A F L A T C C S
26
G T I S H E C N S W F L T C C S
4
G V F K T I S H E C H M N S W Q F L F T C C S
26
61.5%
NZ_CAAHKQ010000003.1:
Lanthipeptides: E9664_RS02165_lanthipeptide
3
K G A V G T I S H E C R Y N S W A F L A T C C S
26
G T I S H E C N+W A F L A C C S
3
N G V F K T I S H E C H L N T W A F L A I C C S
26
61.5%
NZ_CP060646.1:
Lanthipeptides: H7789_RS06845_lanthipeptide
3
K G A V G T I S H E C R Y N S W A F L A T C C S
26
G T I S H E C N+W A L A T C C S
3
N G V F K T I S H E C H L N T W A S L A T C C S
26
61.5%
NZ_MSRJ01000005.1:
Lanthipeptides: BKH06_RS03755_lanthipeptide
3
K G A V G T I S H E C R Y N S W A F L A T C C S
26
+G V T I S H E C N S W F+ T C C S
1
E G V V T T I S H E C N M N S W Q F I F T C C S
24

#### MIBiG 4.0 matches for CO204_RS01885

21.4%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
2
G K G A V G T I S H E C
13
K G A T++ E C
12
N K G A Y C T L T V E C
23
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
8
T I S H E C R Y N
16
T+S E C+ N
29
T L S K E C Q P N
37
CO204_RS01890
Leader:
MKKGTQLYLEALEALQEIKVEELDTFIGG
Core:
G G R A S N T I S S D C R W N S L Q A I F S C C
Core with dehydrations:
G G R A Dha N Dhb I Dha Dha D Cys R W N Dha L Q A I F Dha Cys Cys

#### antiSMASH-DB 4.0 matches for CO204_RS01890

100.0%
NC_013928.1 and 4 others:
NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide
Lanthipeptides: SMUNN2025_RS09965_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G G R A S N T I S S D C R W N S L Q A I F S C C
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
75.0%
NZ_ALSD01000046.1 and 5 others:
NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptide NZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide
Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G N T I S++C R W N S L Q A I F S C C
1
A G H G V N T I S A E C R W N S L Q A I F S C C
24
75.0%
NZ_CAAHHE010000002.1 and 13 others:
NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptide NZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptide NZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptide NZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptide
Lanthipeptides: E9499_RS02930_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G G N T I S++C R W N S L Q A I F+C C
1
G G H G V N T I S A E C R W N S L Q A I F T C C
24
with 50 more sequence matches
Only the first 10 are displayed here.
70.8%
NC_012470.1 and 15 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptide NZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide
Lanthipeptides: SZO_RS10260_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G N T I S++C R W N S L Q A I F+C C
1
A G H G V N T I S A E C R W N S L Q A I F T C C
24
70.8%
NZ_CAAHGW010000010.1 and 12 others:
NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptide NZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptide NZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptide NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptide NZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptide
Lanthipeptides: E9435_RS08895_lanthipeptide
2
G R A S N T I S S D C R W N S L Q A I F S C C
24
G N T I S++C R W N S L Q A I F+C C
2
G H G V N T I S A E C R W N S L Q A I F T C C
24
52.0%
NZ_JH792236.1 and 1 other:
NZ_JH792236.1 Lanthipeptides: IIM_RS26240_lanthipeptide
Lanthipeptides: IIM_RS26245_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G T I S +C N S Q A I F+C C
1
G S G V I K T I S H E C H M N S W Q A I F T C C
24
52.0%
NZ_VDNV01000006.1:
Lanthipeptides: FSV44_RS08765_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G G T I S +C R N S Q +F+C C
1
G G G V I Q T I S H E C R M N S W Q F L F T C C
24
48.0%
NZ_JAEEGA010000010.1:
Lanthipeptides: I6N95_RS15660_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G T I S +C N S Q I F+C C
1
G N G V I K T I S H E C H M N S W Q W I F T C C
24
45.8%
NZ_GL985606.1:
Lanthipeptides: HMPREF9062_RS00700_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G +T I S +C +N S I F+C C
1
G N G V F H T I S H E C Y Y N S W A F I F T C C
24
45.8%
NZ_MSRJ01000005.1:
Lanthipeptides: BKH06_RS03755_lanthipeptide
7
T I S S D C R W N S L Q A I F S C C
24
T I S +C N S Q I F+C C
6
T I S H E C N M N S W Q F I F T C C
23
45.8%
NZ_QTVL01000002.1 and 5 others:
NZ_QTVL01000002.1 Lanthipeptides: DWZ44_RS04150_lanthipeptide NZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14340_lanthipeptide NZ_QTZB01000015.1 Lanthipeptides: DXC15_RS14335_lanthipeptide NZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02940_lanthipeptide NZ_QUKU01000003.1 Lanthipeptides: DXC27_RS02935_lanthipeptide
Lanthipeptides: DWZ44_RS04155_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G T I S +C N+ Q I F+C C
1
G D G V F R T I S H E C N M N T W Q F I F T C C
24
44.0%
NZ_CP023483.1:
Lanthipeptides: CNY62_RS11970_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G A T I S +C N+ Q +F+C C
1
G N G A I R T I S H E C H M N T W Q F L F T C C
24
44.0%
NZ_CP026729.1:
Lanthipeptides: BKKJ1_RS07010_lanthipeptide
1
G G R A S N T I S S D C R W N S L Q A I F S C C
24
G T I S +C N S Q +F+C C
1
G N G V V T T I S H E C N M N S W Q F L F T C C
24

#### MIBiG 4.0 matches for CO204_RS01890

20.8%
BGC0002111.3 (EVG22_32245):
Lanthipeptide: andalusicin A or andalusicin B
2
G R A S N T I S S D C
12
G ++T I S++C
13
G A W A S T I S N N C
23
20.8%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
2
G R A S N T I S S D C
12
G ++T I S++C
13
G V W A S T I S N N C
23
10.3%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
7
T I S S D C R W N
15
T+S +C+ N
29
T L S K E C Q P N
37

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.03 out of 18.46
Confidence: medium
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

CO204_RS01875 - Class II
  Cleavage pHMM score: 4.60
  RODEO score: 0
  Monoisotopic mass: 2713.2 Da
  Molecular weight: 2715.1 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2733.1 Da N = 1
    2751.1 Da N = 2
    2769.2 Da N = 3
CO204_RS01880 - Class II
  Cleavage pHMM score: 4.60
  RODEO score: 0
  Monoisotopic mass: 2669.3 Da
  Molecular weight: 2671.1 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2689.2 Da N = 1
CO204_RS01885 - Class II
  Cleavage pHMM score: 4.60
  RODEO score: 0
  Monoisotopic mass: 2701.2 Da
  Molecular weight: 2703.1 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2721.1 Da N = 1
    2739.1 Da N = 2
CO204_RS01890 - Class II
  Cleavage pHMM score: 1.70
  RODEO score: 0
  Monoisotopic mass: 2467.1 Da
  Molecular weight: 2468.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2486.7 Da N = 1
    2504.8 Da N = 2
    2522.8 Da N = 3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP023477.1 - Region 3 - RRE-containing,RaS-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 625,900 - 648,398 nt. (total: 22,499 nt) Show pHMM detection rules used
RaS-RiPP: (PF04055 and TIGR01716)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RaS-RiPP | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002583.2 |  |  | 1.88 | ribosomal | tryglysin B | Streptococcus mutans UA159
BGC0001929.2 |  |  | 0.95 | ribosomal | WGK | Streptococcus ferus
BGC0001209.3 |  |  | 0.47 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0001025.5 |  |  | 0.10 | NRPS, PKS | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0001956.3 |  |  | 0.08 | PKS | miharamycin A, miharamycin B | Streptomyces miharaensis
BGC0002479.3 |  |  | 0.08 | NRPS, PKS, saccharide | miharamycin B, miharamycin A | Streptomyces miharaensis
BGC0002326.2 |  |  | 0.06 | NRPS | endopyrrole B, endopyrrole C, endopyrrole A | Mycetohabitans rhizoxinica

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002583.2 |  | 0.98 | ribosomal | tryglysin B | Streptococcus mutans UA159
BGC0001929.2 |  | 0.77 | ribosomal | WGK | Streptococcus ferus
BGC0001209.3 |  | 0.57 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0002326.2 |  | 0.25 | NRPS | endopyrrole B, endopyrrole C, endopyrrole A | Mycetohabitans rhizoxinica
BGC0001025.5 |  | 0.22 | NRPS, PKS | myxovirescin A1 | Myxococcus xanthus DK 1622
BGC0001956.3 |  | 0.19 | PKS | miharamycin A, miharamycin B | Streptomyces miharaensis
BGC0002479.3 |  | 0.19 | NRPS, PKS, saccharide | miharamycin B, miharamycin A | Streptomyces miharaensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16
Confidence: strong
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.33 out of 32.93
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.23 out of 28.14
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.01 out of 28.19
Confidence: medium
Additional weak hits (5):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.06 out of 26.85
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.82 out of 28.14
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.01 out of 26.85
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RaS-RiPP protocluster (625899...648078)
CO204_RS03405
  RRE type: Streptide_RRE
  Location: 5 - 105
  Score: 129.2
  RRE type: Stand_Alone_Lasso_RRE
  Location: 5 - 79
  Score: 33.2
RRE-containing protocluster (628074...648398)
CO204_RS03405
  RRE type: Streptide_RRE
  Location: 5 - 105
  Score: 129.2
  RRE type: Stand_Alone_Lasso_RRE
  Location: 5 - 79
  Score: 33.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
LexA variant 3 | Repressor of DNA damage response
PerR | Peroxide regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP023477.1 - Region 4 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,105,885 - 1,147,060 nt. (total: 41,176 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase reductase
CO204_RS05755: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

CO204_RS05845: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

CO204_RS05930: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Transferases: aminotransferase
CO204_RS05795: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Ligases: synthase
CO204_RS05840: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Translocases: permease
CO204_RS05805: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000513.3 |  | 0.50 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000883.5 |  | 0.44 | other (other) | arginomycin | Streptomyces arginensis
BGC0002561.3 |  | 0.44 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000557.5 |  | 0.44 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0001788.3 |  | 0.44 | ribosomal | suicin 65 | Streptococcus suis
BGC0000521.3 |  | 0.44 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000547.5 |  | 0.44 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0002294.3 |  | 0.44 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000539.5 |  | 0.44 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000526.5 |  | 0.43 | ribosomal | macedocin | Streptococcus macedonicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000513.3 |  | 0.50 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000883.5 |  | 0.44 | other (other) | arginomycin | Streptomyces arginensis
BGC0002561.3 |  | 0.44 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000557.5 |  | 0.44 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0001788.3 |  | 0.44 | ribosomal | suicin 65 | Streptococcus suis
BGC0000521.3 |  | 0.44 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000547.5 |  | 0.44 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0002294.3 |  | 0.44 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000539.5 |  | 0.44 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000526.5 |  | 0.43 | ribosomal | macedocin | Streptococcus macedonicus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.31 out of 28.14
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.42 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.13 out of 20.97
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.99 out of 27.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.52 out of 28.19
Confidence: strong
Additional weak hits (6):
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.84 out of 27.04
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.71 out of 20.47
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.71 out of 25.75
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.34 out of 33.14
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
PerR | Peroxide regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP023477.1 - Region 5 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,400,312 - 1,424,545 nt. (total: 24,234 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase protease
CO204_RS07185: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

CO204_RS07240: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: cyclase dehydratase
CO204_RS07195: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

CO204_RS07200: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000533.3 |  | 1.00 | ribosomal | mutacin III | Streptococcus mutans
BGC0000531.3 |  | 0.90 | ribosomal | mutacin I | Streptococcus mutans
BGC0000530.5 |  | 0.81 | ribosomal | mutacin B-Ny266 | Streptococcus mutans N66
BGC0001618.3 |  | 0.68 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002635.2 |  | 0.58 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0000514.5 |  | 0.56 | ribosomal | gallidermin | Staphylococcus gallinarum
BGC0000504.5 |  | 0.54 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002668.2 |  | 0.53 | ribosomal | cesin A | Clostridium estertheticum
BGC0002323.2 |  | 0.52 | ribosomal | nisin J | Staphylococcus capitis
BGC0000541.5 |  | 0.52 | ribosomal | paenicidin A | Paenibacillus polymyxa

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000533.3 |  | 1.00 | ribosomal | mutacin III | Streptococcus mutans
BGC0000531.3 |  | 0.90 | ribosomal | mutacin I | Streptococcus mutans
BGC0000530.5 |  | 0.81 | ribosomal | mutacin B-Ny266 | Streptococcus mutans N66
BGC0001618.3 |  | 0.68 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002635.2 |  | 0.58 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0000514.5 |  | 0.56 | ribosomal | gallidermin | Staphylococcus gallinarum
BGC0000504.5 |  | 0.54 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002668.2 |  | 0.53 | ribosomal | cesin A | Clostridium estertheticum
BGC0002323.2 |  | 0.52 | ribosomal | nisin J | Staphylococcus capitis
BGC0000541.5 |  | 0.52 | ribosomal | paenicidin A | Paenibacillus polymyxa

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for CO204_RS07200

CO204_RS07210
Leader:
MSNTQLLEVLGTETFDVQEDLFAFDTTDTTIVASNDDPDTR
Core:
F K S W S L C T P G C A R T G S F N S Y C C
Core with dehydrations:
F K Dha W Dha L Cys Dhb P G Cys A R Dhb G Dha F N Dha Y Cys Cys

#### antiSMASH-DB 4.0 matches for CO204_RS07210

100.0%
NZ_CP023477.1:
Lanthipeptides: CO204_RS07210_lanthipeptide
1
F K S W S L C T P G C A R T G S F N S Y C C
22
F K S W S L C T P G C A R T G S F N S Y C C
1
F K S W S L C T P G C A R T G S F N S Y C C
22
81.8%
NZ_AP019791.1:
Lanthipeptides: RxyAA322_RS06460_lanthipeptide
1
F K S W S L C T P G C A R T G S F N S Y C C
22
S+S L C T P G C A+T G S F N S Y C C
1
I T S Y S L C T P G C A K T G S F N S Y C C
22
77.3%
NZ_FNNQ01000006.1 and 2 others:
NZ_FNNQ01000006.1 Lanthipeptides: BLV90_RS07685_lanthipeptide NZ_FNNQ01000006.1 Lanthipeptides: BLV90_RS07680_lanthipeptide
Lanthipeptides: BLV90_RS07690_lanthipeptide
1
F K S W S L C T P G C A R T G S F N S Y C C
22
S S L C T P G C T G S F N S Y C C
1
I T S V S L C T P G C G E T G S F N S Y C C
22
with 105 more sequence matches
Only the first 10 are displayed here.
77.3%
NZ_FPAA01000016.1 and 3 others:
NZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15995_lanthipeptide NZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15990_lanthipeptide NZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15985_lanthipeptide
Lanthipeptides: CHX35_RS16000_lanthipeptide
1
F K S W S L C T P G C A R T G S F N S Y C C
22
S S L C T P G C T G S F N S Y C C
1
I T S V S L C T P G C G D T G S F N S Y C C
22
75.0%
NZ_VKCY01000012.1:
Lanthipeptides: FNK43_RS09020_lanthipeptide
3
S W S L C T P G C A R T G S F N S Y C C
22
S+S L C T P G C A+T G S F N S Y C C
5
S F S L C T P G C A K T G S F N S Y C C
24
73.9%
NC_003923.1 and 9 others:
NC_009641.1 Lanthipeptides: NWMN_RS09635_lanthipeptide NZ_CP023076.1 Lanthipeptides: CJ017_RS08945_lanthipeptide NZ_CP054876.1 Lanthipeptides: HUW54_RS09150_lanthipeptide NZ_CP077098.1 Lanthipeptides: KSF82_RS09475_lanthipeptide NZ_CP092781.1 Lanthipeptides: ML436_RS08940_lanthipeptide NZ_CP102959.1 Lanthipeptides: NW979_RS08780_lanthipeptide NZ_CP102962.1 Lanthipeptides: NW971_RS09555_lanthipeptide NZ_LR133917.1 Lanthipeptides: ELZ45_RS09155_lanthipeptide NZ_LS483317.1 Lanthipeptides: DQL75_RS09700_lanthipeptide
Lanthipeptides: MW_RS09420_lanthipeptide
3
S W S L C T P G C A R T G S F N S Y C C
22
S S L C T P G C A+T G S F N S+C C
4
S H S L C T P G C A K T G S F N S F C C
23
73.9%
NZ_CP047792.1 and 1 other:
NZ_JAGSAY010000004.1 Lanthipeptides: KC186_RS06745_lanthipeptide
Lanthipeptides: E3S88_RS07345_lanthipeptide
1
F K S W S L C T P G C A R T G S F N S Y C C
22
S S L C T P G C A T G S F N S+C C
2
I T S H S L C T P G C A N T G S F N S F C C
23
72.7%
NC_006582.1 and 6 others:
NZ_BOQQ01000001.1 Lanthipeptides: KI354_RS00530_lanthipeptide NZ_BOQS01000001.1 Lanthipeptides: KI364_RS00675_lanthipeptide NZ_CP019985.1 Lanthipeptides: BC8716_RS09795_lanthipeptide NZ_CP104963.1 Lanthipeptides: N7M99_RS07725_lanthipeptide NZ_FRBS01000002.1 Lanthipeptides: BUC05_RS08990_lanthipeptide NZ_JAODPB010000001.1 Lanthipeptides: N6H06_RS03040_lanthipeptide
Lanthipeptides: ABC_RS22115_lanthipeptide
1
F K S W S L C T P G C A R T G S F N S Y C C
22
F S S C T P G C T G S F N S+C C
1
F T S V S F C T P G C G E T G S F N S F C C
22
72.7%
NZ_CP094805.1:
Lanthipeptides: MUA37_RS13310_lanthipeptide
6
L C T P G C A R T G S F N S Y C C
22
L C T P G C A+T G S F N S Y C C
6
L C T P G C A K T G S F N S Y C C
22
72.7%
NZ_LELK01000004.1:
Lanthipeptides: AB986_RS12540_lanthipeptide
1
F K S W S L C T P G C A R T G S F N S Y C C
22
S+S C T P G C T G S F N S Y C C
1
I T S Y S F C T P G C G E T G S F N S Y C C
22
68.2%
NC_014023.1 and 36 others:
NC_014023.1 Lanthipeptides: BMQ_RS27575_lanthipeptide NZ_CP018875.1 Lanthipeptides: BUW91_RS26425_lanthipeptide NZ_CP018875.1 Lanthipeptides: BUW91_RS26420_lanthipeptide NZ_CP028091.1 Lanthipeptides: C1N54_RS28075_lanthipeptide NZ_CP028091.1 Lanthipeptides: C1N54_RS28070_lanthipeptide NZ_CP028091.1 Lanthipeptides: C1N54_RS28065_lanthipeptide NZ_CP031776.1 Lanthipeptides: D0441_RS30140_lanthipeptide NZ_CP041065.1 Lanthipeptides: FJM50_RS01185_lanthipeptide NZ_CP041065.1 Lanthipeptides: FJM50_RS01180_lanthipeptide NZ_CP041065.1 Lanthipeptides: FJM50_RS01175_lanthipeptide NZ_CP048884.1 Lanthipeptides: BMG_RS27510_lanthipeptide NZ_CP058263.1 Lanthipeptides: HW576_RS26980_lanthipeptide NZ_CP058263.1 Lanthipeptides: HW576_RS26975_lanthipeptide NZ_CP058263.1 Lanthipeptides: HW576_RS26970_lanthipeptide NZ_CP085427.1 Lanthipeptides: LIT30_RS26985_lanthipeptide NZ_CP085427.1 Lanthipeptides: LIT30_RS26980_lanthipeptide NZ_CP085427.1 Lanthipeptides: LIT30_RS26975_lanthipeptide NZ_CP085432.1 Lanthipeptides: LIT34_RS27820_lanthipeptide NZ_CP085432.1 Lanthipeptides: LIT34_RS27815_lanthipeptide NZ_CP085432.1 Lanthipeptides: LIT34_RS27810_lanthipeptide NZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25635_lanthipeptide NZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25630_lanthipeptide NZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25625_lanthipeptide NZ_JAHHYI010000015.1 Lanthipeptides: KM925_RS26245_lanthipeptide NZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28075_lanthipeptide NZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28070_lanthipeptide NZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28065_lanthipeptide NZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19640_lanthipeptide NZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19635_lanthipeptide NZ_NTZG01000054.1 Lanthipeptides: CN510_RS18265_lanthipeptide NZ_NUIN01000020.1 Lanthipeptides: CN973_RS26930_lanthipeptide NZ_NUOI01000090.1 Lanthipeptides: COE08_RS30285_lanthipeptide NZ_NUOI01000090.1 Lanthipeptides: COE08_RS30280_lanthipeptide NZ_NUOQ01000009.1 Lanthipeptides: COE31_RS05925_lanthipeptide NZ_NUXL01000007.1 Lanthipeptides: COJ36_RS20885_lanthipeptide NZ_NUZS01000089.1 Lanthipeptides: COJ90_RS28785_lanthipeptide
Lanthipeptides: BMQ_RS27580_lanthipeptide
1
F K S W S L C T P G C A R T G S F N S Y C C
22
S S L C T P G C T G S+N S+C C
1
I T S V S L C T P G C G D T G S W N S F C C
22
68.2%
NC_022873.1 and 92 others:
NZ_CM000742.1 Lanthipeptides: BMYCO0001_RS26515_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18180_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18175_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18170_lanthipeptide NZ_CP011151.1 Lanthipeptides: WR47_RS18165_lanthipeptide NZ_CP015350.1 Lanthipeptides: BT246_RS19775_lanthipeptide NZ_CP015350.1 Lanthipeptides: BT246_RS19770_lanthipeptide NZ_CP015350.1 Lanthipeptides: BT246_RS19765_lanthipeptide NZ_CP017060.1 Lanthipeptides: FORC47_RS18710_lanthipeptide NZ_CP017060.1 Lanthipeptides: FORC47_RS18705_lanthipeptide NZ_CP017060.1 Lanthipeptides: FORC47_RS18700_lanthipeptide NZ_CP026678.1 Lanthipeptides: C2I25_RS21370_lanthipeptide NZ_CP026678.1 Lanthipeptides: C2I25_RS21365_lanthipeptide NZ_CP026678.1 Lanthipeptides: C2I25_RS21360_lanthipeptide NZ_CP035965.1 Lanthipeptides: EXW35_RS16385_lanthipeptide NZ_CP035965.1 Lanthipeptides: EXW35_RS16380_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16155_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16150_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16145_lanthipeptide NZ_CP035994.1 Lanthipeptides: EXW32_RS16140_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26195_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26190_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26185_lanthipeptide NZ_CP035999.1 Lanthipeptides: EXW27_RS26180_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16265_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16260_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16255_lanthipeptide NZ_CP036099.1 Lanthipeptides: EXW47_RS16250_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16620_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16615_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16610_lanthipeptide NZ_CP036117.1 Lanthipeptides: EXW43_RS16605_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16110_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16105_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16100_lanthipeptide NZ_CP036145.1 Lanthipeptides: EXW57_RS16095_lanthipeptide NZ_CP040334.1 Lanthipeptides: EUC39_RS14125_lanthipeptide NZ_CP040334.1 Lanthipeptides: EUC39_RS14120_lanthipeptide NZ_CP040334.1 Lanthipeptides: EUC39_RS14115_lanthipeptide NZ_CP045606.2 Lanthipeptides: GE376_RS18355_lanthipeptide NZ_CP045606.2 Lanthipeptides: GE376_RS18350_lanthipeptide NZ_CP045606.2 Lanthipeptides: GE376_RS18345_lanthipeptide NZ_CP047366.1 Lanthipeptides: GSN03_RS15835_lanthipeptide NZ_CP047366.1 Lanthipeptides: GSN03_RS15830_lanthipeptide NZ_CP071811.1 Lanthipeptides: EXW36_RS16415_lanthipeptide NZ_CP071811.1 Lanthipeptides: EXW36_RS16410_lanthipeptide NZ_CP071811.1 Lanthipeptides: EXW36_RS16405_lanthipeptide NZ_CP072061.1 Lanthipeptides: J5V93_RS15130_lanthipeptide NZ_CP072061.1 Lanthipeptides: J5V93_RS15125_lanthipeptide NZ_CP072061.1 Lanthipeptides: J5V93_RS15120_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15990_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15985_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15980_lanthipeptide NZ_CP084035.1 Lanthipeptides: LCF45_RS15975_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25975_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25970_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25965_lanthipeptide NZ_CP093291.1 Lanthipeptides: MN093_RS25960_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15810_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15805_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15800_lanthipeptide NZ_CP093835.1 Lanthipeptides: MN034_RS15795_lanthipeptide NZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24265_lanthipeptide NZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24260_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06155_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06150_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06145_lanthipeptide NZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06140_lanthipeptide NZ_JH792114.1 Lanthipeptides: II3_RS21535_lanthipeptide NZ_JH792114.1 Lanthipeptides: II3_RS21530_lanthipeptide NZ_JH792114.1 Lanthipeptides: II3_RS21525_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11095_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11090_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11085_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11080_lanthipeptide NZ_JH792251.1 Lanthipeptides: III_RS11075_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18900_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18895_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18890_lanthipeptide NZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18885_lanthipeptide NZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26430_lanthipeptide NZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26425_lanthipeptide NZ_MOOL01000076.1 Lanthipeptides: BK733_RS27280_lanthipeptide NZ_MOOL01000076.1 Lanthipeptides: BK733_RS27275_lanthipeptide NZ_MOOL01000076.1 Lanthipeptides: BK733_RS27270_lanthipeptide NZ_MSTN01000016.1 Lanthipeptides: BVF97_RS28620_lanthipeptide NZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08145_lanthipeptide NZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08140_lanthipeptide NZ_NKAX01000026.1 Lanthipeptides: CE086_RS26165_lanthipeptide NZ_NKAX01000026.1 Lanthipeptides: CE086_RS26160_lanthipeptide NZ_NVGU01000011.1 Lanthipeptides: COL71_RS14760_lanthipeptide NZ_NVGU01000011.1 Lanthipeptides: COL71_RS14755_lanthipeptide
Lanthipeptides: YBT1518_RS19670_lanthipeptide
1
F K S W S L C T P G C A R T G S F N S Y C C
22
S S C T P G C T G S F N S+C C
1
I T S I S A C T P G C G N T G S F N S F C C
22
68.2%
NZ_CP090942.1:
Lanthipeptides: LZT96_RS12010_lanthipeptide
6
L C T P G C A R T G S F N S Y C C
22
+C T P G C A+T G S F N S Y C C
6
I C T P G C A K T G S F N S Y C C
22

#### MIBiG 4.0 matches for CO204_RS07210

29.4%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
F K S W S L C T P G C A R T G S F
17
S S L C T P G C +T G+
1
I T S I S L C T P G C-K T G A L
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.91 out of 26.06
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52
Confidence: medium
Additional weak hits (2):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.10 out of 26.85
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.64 out of 30.97
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

CO204_RS07210 - Class I
  Cleavage pHMM score: 18.60
  RODEO score: 31
  Monoisotopic mass: 2263.0 Da
  Molecular weight: 2264.6 Da
  Number of bridges: 3
  Additional modifications: AviCys
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2282.6 Da N = 1
    2300.7 Da N = 2

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (1400311...1424545)
CO204_RS07200
  RRE type: Lanthipeptide_LanB_RRE
  Location: 170 - 233
  Score: 37.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP023477.1 - Region 6 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,473,054 - 1,493,923 nt. (total: 20,870 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthetase
CO204_RS07525: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000668.5 |  | 0.29 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001756.3 |  | 0.28 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana
BGC0001605.3 |  | 0.28 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001594.3 |  | 0.27 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000648.3 |  | 0.27 | terpene | carotenoid | Myxococcus xanthus
BGC0000679.5 |  | 0.27 | terpene | diazepinomicin | Micromonospora sp. M42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000668.5 |  | 0.29 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001756.3 |  | 0.28 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana
BGC0001605.3 |  | 0.28 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001594.3 |  | 0.27 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000648.3 |  | 0.27 | terpene | carotenoid | Myxococcus xanthus
BGC0000679.5 |  | 0.27 | terpene | diazepinomicin | Micromonospora sp. M42

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
CO204_RS07525: PT_FPPS_like
Domain 1 (25 - 283): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.49 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.33 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97
Confidence: strong
Additional weak hits (3):
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.93 out of 20.47
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.60 out of 30.97
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
FuR variant 1 | Ferric Uptake Regulator
ToxT | Regulator of MSHA biosynthesis

NZ_CP023477.1 - Region 7 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,631,886 - 1,642,116 nt. (total: 10,231 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: back translocase hydrolase
CO204_RS08280: hydrolase

smcogs
  SMCOG1179: hydrolase

CO204_RS08310: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002436.2 |  | 0.34 | other (other) | coformycin | Streptomyces citricolor
BGC0002462.3 |  | 0.31 | saccharide | coformycin | Streptomyces kaniharaensis
BGC0001591.4 |  | 0.27 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000259.3 |  | 0.26 | PKS | prodigiosin | Serratia marcescens
BGC0000969.5 |  | 0.26 | NRPS, PKS | chondramide A | Chondromyces crocatus
BGC0000207.5 |  | 0.23 | PKS | chartreusin | Streptomyces chartreusis
BGC0002131.4 |  | 0.21 | NRPS, PKS, saccharide | aurantoside A | Chloroflexi bacterium TSY
BGC0002435.3 |  | 0.21 | other (other) | coformycin, aristeromycin | Micromonospora haikouensis
BGC0002040.3 |  | 0.19 | other (other) | coformycin, formycin A | Streptomyces kaniharaensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002436.2 |  | 0.34 | other (other) | coformycin | Streptomyces citricolor
BGC0002462.3 |  | 0.31 | saccharide | coformycin | Streptomyces kaniharaensis
BGC0001591.4 |  | 0.27 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000259.3 |  | 0.26 | PKS | prodigiosin | Serratia marcescens
BGC0000969.5 |  | 0.26 | NRPS, PKS | chondramide A | Chondromyces crocatus
BGC0000207.5 |  | 0.23 | PKS | chartreusin | Streptomyces chartreusis
BGC0002131.4 |  | 0.21 | NRPS, PKS, saccharide | aurantoside A | Chloroflexi bacterium TSY
BGC0002435.3 |  | 0.21 | other (other) | coformycin, aristeromycin | Micromonospora haikouensis
BGC0002040.3 |  | 0.19 | other (other) | coformycin, formycin A | Streptomyces kaniharaensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.87 out of 29.25
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.83 out of 21.55
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.66 out of 23.79
Confidence: medium
Additional weak hits (2):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.41 out of 30.97
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.54 out of 31.73
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization

NZ_CP023477.1 - Region 8 - NRPS,RiPP-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,744,887 - 1,814,746 nt. (total: 69,860 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase synthase
CO204_RS08915: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

CO204_RS08935: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

CO204_RS09025: riboflavin biosynthesis protein RibD

smcogs
  SMCOG1240: riboflavin biosynthesis protein RibD

Transferases: PPTase transketolase
CO204_RS08950: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

CO204_RS09090: transketolase

smcogs
  SMCOG1204: transketolase

Hydrolases: esterase synthase
CO204_RS08945: thioesterase

smcogs
  SMCOG1004: thioesterase

CO204_RS09025: riboflavin biosynthesis protein RibD

smcogs
  SMCOG1240: riboflavin biosynthesis protein RibD

Ligases: ligase synthase
CO204_RS08965: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

CO204_RS08995: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

CO204_RS09000: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

CO204_RS09005: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001251.4 |  |  |  | 0.76 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  |  |  | 0.75 | NRPS | epichloenin A | Epichloe festucae
BGC0001132.4 |  |  |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.3 |  |  |  | 0.73 | NRPS | AM-toxin | Alternaria alternata
BGC0001833.4 |  |  |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  |  |  | 0.72 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001166.5 |  |  |  | 0.71 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001825.4 |  |  |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  |  |  | 0.70 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  |  |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001251.4 |  | 0.70 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  | 0.70 | NRPS | epichloenin A | Epichloe festucae
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.69 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.37 out of 28.14
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.47 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.65 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.32 out of 29.38
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.46 out of 29.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.69 out of 27.78
Confidence: medium
Additional weak hits (6):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.89 out of 39.62
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.49 out of 26.85
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.17 out of 20.01
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.99 out of 36.53
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 28.76 out of 39.62
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.25 out of 29.38
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 1744886 - 1814746:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal - X - X) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 1744886 - 1800556:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal - X - X) + (Ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
CO204_RS08965: Hpr
Search NORINE for peptide: strict or relaxed
AMP-binding (27..442): Hpr
nrpys: Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    N/A
  Single AA prediction:
    pip (Hpr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    NIMLFDMGIGSNIAINGSENPAYGLAENTLIVSA
  Nearest Stachelhaus code(s):
    Val DAAIIGAVIK (35% 8Å match)
  Stachelhaus code match:
    70% (weak)

CO204_RS08995: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (445..842): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFICSGEVNLYGPTEAAIDVSC
  Nearest Stachelhaus code(s):
    Ser DVWHISLIDK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

CO204_RS09005: mal - X - X
PKS_AT (605..884): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 75.0%
  Isobutyryl-CoA: 66.7%
  Methylmalonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 85.6
  Methylmalonyl-CoA: 79.1
  Methoxymalonyl-CoA: 78.1
  Propionyl-CoA: 44.0
  inactive: 34.2
  fatty_acid: 29.0
  CHC-CoA: 28.2
  Ethylmalonyl-CoA: 28.0
  Isobutyryl-CoA: 27.4
  Benzoyl-CoA: 22.6
  2-Methylbutyryl-CoA: 20.7
  Acetyl-CoA: 20.2
  trans-1,2-CPDA: 17.0
  3-Methylbutyryl-CoA: 7.1

AMP-binding (1515..1893): X
nrpys: Ph-Ser, Phe

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VEQAFDASVFDMTLVTAGEYNAYGVTEATIWNTT
  Nearest Stachelhaus code(s):
    Ph-Ser or Phe DAFTVAAIWK (71% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2562..2925): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FWESHDPILRDVNIFFGGEVNYYGTTETPQGMSF
  Nearest Stachelhaus code(s):
    D-Glu DPRHSGVVGK (47% 8Å match)
    Htia DPHHFGLIGK (41% 8Å match)
  Stachelhaus code match:
    60% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
PerR | Peroxide regulator
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis

NZ_CP023477.1 - Region 9 - HR-T2PKS,butyrolactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,900,586 - 1,942,679 nt. (total: 42,094 nt) Show pHMM detection rules used
HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
butyrolactone: AfsA

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
CO204_RS09745: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

CO204_RS09750: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

CO204_RS09775: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

CO204_RS09785: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase phosphotransferase
CO204_RS09765: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

CO204_RS09865: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: glucosidase
CO204_RS09860: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

Lyases: dehydratase
CO204_RS09825: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase
CO204_RS09795: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | HR-T2PKS | butyrolactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002306.2 |  |  | 0.26 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001210.5 |  |  | 0.26 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000539.5 |  |  | 0.25 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000626.3 |  |  | 0.25 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000521.3 |  |  | 0.25 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000497.3 |  |  | 0.24 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000514.5 |  |  | 0.24 | ribosomal | gallidermin | Staphylococcus gallinarum
BGC0002323.2 |  |  | 0.24 | ribosomal | nisin J | Staphylococcus capitis
BGC0001579.4 |  |  | 0.24 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0001618.3 |  |  | 0.24 | ribosomal | hyicin 3682 | Staphylococcus hyicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002285.2 |  | 0.46 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0000231.5 |  | 0.45 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001940.3 |  | 0.44 | PKS | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000838.3 |  | 0.44 | PKS | flexirubin | Flavobacterium johnsoniae UW101
BGC0001209.3 |  | 0.44 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0001651.3 |  | 0.43 | other (other) | legionaminic acid | Tannerella forsythia 92A2
BGC0000531.3 |  | 0.43 | ribosomal | mutacin I | Streptococcus mutans
BGC0002047.2 |  | 0.43 | PKS | brasiliquinone A, brasiliquinone B | Nocardia brasiliensis
BGC0000533.3 |  | 0.43 | ribosomal | mutacin III | Streptococcus mutans
BGC0002449.2 |  | 0.43 | other (other) | sarasinoside | uncultured bacterium

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.95 out of 25.88
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.23 out of 20.97
Confidence: strong
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.22 out of 32.93
Confidence: medium
Additional weak hits (5):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.39 out of 28.14
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.95 out of 20.01
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
LexA variant 3 | Repressor of DNA damage response
MexT | Global virulence regulator
PsrA | Oleic acid responsive regulator