LOCUS       NZ_PVZV01000004        22546 bp    DNA     linear   CON 13-DEC-2024
DEFINITION  Actinocorallia populi strain A251 contig4, whole genome shotgun
            sequence.
ACCESSION   NZ_PVZV01000004
VERSION     NZ_PVZV01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinocorallia populi
  ORGANISM  Actinocorallia populi
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Thermomonosporaceae; Actinocorallia.
REFERENCE   1  (bases 1 to 749123)
  AUTHORS   Li,X.
  TITLE     Actinocorallia populi sp. nov., an endophytic actinomycete isolated
            from a root of Populus adenopoda (Maxim.)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 749123)
  AUTHORS   Li,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-MAR-2018) College of Light Industry, Textile and Food
            Engineering, Sichuan University, No. 24, First South Section First
            Ring Road, Chengdu, Sichuan 610065, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR MAR-2018
            Expected Final Version            :: yes
            Genome Coverage                   :: 221.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002995495.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 14:18:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,861
            CDSs (total)                      :: 7,799
            Genes (coding)                    :: 7,716
            CDSs (with protein)               :: 7,716
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 18 of 83
            Pseudo Genes (incomplete)         :: 70 of 83
            Pseudo Genes (internal stop)      :: 6 of 83
            Pseudo Genes (multiple problems)  :: 10 of 83
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:05:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 456848
            Orig. end                         :: 479394
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            PVZV01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22546
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="5"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22546
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22546
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12546](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12546)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            379..2439
                     /locus_tag="C2865_RS18855"
     CDS             379..2439
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (423-538). E-value: 7.4e-10.
                     Score: 31.0. Matches aSDomain:
                     nrpspksdomains_C2865_RS18855_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017567084.1"
                     /locus_tag="C2865_RS18855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional aldolase/short-chain dehydrogenase"
                     /protein_id="WP_106399796.1"
                     /transl_table=11
                     /translation="MSDAVNTVVQDLLNRCHELGADPRNTNYAGGNASAKGVETDPVTG
                     EPVDLMWVKGSGGDLGTLKASGLAVLRLDRLRALVNVYPGVEREDEMVAAFDFCAHGKG
                     GAAPSIDTAMHGLVEAAHVDHLHPDSGIAIATAEDGEELTRRIFGDRVAWVPWRRPGFQ
                     LGLDIAAIKAENPQAIGVILGGHGITAWGETSQECQANSLEIIGTAEAFLAEHGRPEPF
                     GPVIPGYEPLPEAERRARAAELFPLVRGLASTDKPQVGHFTDDDAVLDFVSRAEHPRLA
                     ALGTSCPDHFLRTKVSPLVLDLAPGAPLDEVKARLKELHAAYRADYAAYYDRHATPESP
                     AMRGADPAIVLVPGVGMFSFGANKQTARVAGEFYVNAINVMRGAESVSRYAPIEESEKF
                     RIEYWSLEEAKLQRMPKPKPLATRVAFVTGGGSGIGAATARRLASEGACVVVADRDLAA
                     AEKVAAELGAGALRASDVAIAVAADVTSEDEIKAALAAAVLAFGGVDLVVNNAGLSLSK
                     PLLETTVADWDLQHDVMARGSFLVSREAARIMIEQAMGGDVVYISSKNSIFAGPNNIAY
                     SATKADQAHQVRLLAAELGEHGVRVNGINPDGVVRGSGIFASGWGANRAAVYGVEEEKL
                     GEFYAQRTLLKREVLPEHVANAVFALTGGDLTHTTGLHIPVDAGVAAAFLR"
     aSDomain        1648..1992
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2865_RS18855_PKS_KR.1"
                     /evalue="7.40E-10"
                     /label="C2865_RS18855_PKS_KR.1"
                     /locus_tag="C2865_RS18855"
                     /protein_end="538"
                     /protein_start="423"
                     /score="31.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAFVTGGGSGIGAATARRLASEGACVVVADRDLAAAEKVAAELGA
                     GALRASDVAIAVAADVTSEDEIKAALAAAVLAFGGVDLVVNNAGLSLSKPLLETTVADW
                     DLQHDVMARGS"
     CDS_motif       1657..1728
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C2865_RS18855_0001"
                     /evalue="5.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="C2865_RS18855"
                     /protein_end="450"
                     /protein_start="426"
                     /score="16.0"
                     /tool="antismash"
                     /translation="VTGGGSGIGAATARRLASEGACVV"
     misc_feature    complement(2573..2587)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.6"
                     /tool="antismash"
     gene            2590..5565
                     /locus_tag="C2865_RS18860"
     CDS             2590..5565
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF028442.5"
                     /locus_tag="C2865_RS18860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyl hydrolase"
                     /protein_id="WP_106399797.1"
                     /transl_table=11
                     /translation="MPENSPVFSRRRFLQTAAVAGTAVAVAGGPGGTPAALADAGSTDF
                     PALPASVRPWFRWWWPDGLVDPAEIAREIDQIADAGFGGAEIAAVHHSIKDKSVLDPAG
                     HGWGSAPWIAGVEAALERANRRGIGIDLTLGPAWPSATPTITPDSAAACKELAYGAVKV
                     AAGTEYTGPVPPPLVAAHGDVEEKLRYVHAMRVNAANNTRKEVGLEPASHVALFDAVAD
                     GQISWTAPADGDWYLFAYWERGSGQQPESGPHTAPESYVVDHFSAEGTRAVIDFWEESV
                     LTRELRRLLKRNGGALFEDSFELETDALQWTPKIDEEFEKRRGYALWPVLPAILLNNEN
                     TVFAFDAVLSREVRHDYWETVANLFDERHFRPLRDWAHRLGMKLRAQPYGLNTDAIASS
                     AILDVTEGESLGFKNLDDYRALAGGRDMGGHLVMSSETGAYQGGAYATTWKKIIRTMSG
                     AYAAGLNQTVFHGFSYATAPGVQWPGFAAFTPYDGKVGFSESWGPRQPSWTHINDISDY
                     FARIHAVTQAGSMRADIAVFRQTGYSKTGIGVGWLTSNGVPLGWTHQMISAPLLDLPSA
                     RVRGGRLAPDGPAYKAVVIEGDRFYGRAATLPLDVARKFLSYAKAGLPIVFVGEWSAAT
                     IPGKAVGNENERLRAVLTELFAHPKARVVTTEAELPAALADLGVTPDARYAAASTLLNA
                     HRVDKGMDLYYLSNGKHAESSKGVVAIDHEVTFTRSGRDRVPYLLNLWSGEVERIARYT
                     ENGDDVTVRVALQVNQTCAVILARRAWLREASTGLHAVSTTADSVHYRGSRRLQIRAKA
                     PGTYTTALSDGRTVATEVEAVPAVITPAAWTVTADSWLPGATPVETVKEKVTAELTTLA
                     PWSTIPALQDVSGVGRYTTTFALDASWTDDNGAYLELGEVFDTVRVTLNGKALPPADLI
                     NPVLDLDGHLKKGVNTLVVEVTTTLNNRLRLSDPGVYGANPRQAYGLTGPVRIVPYTKK
                     NL"
     misc_feature    complement(5656..5672)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.48"
                     /tool="antismash"
     gene            5740..6618
                     /locus_tag="C2865_RS18865"
     CDS             5740..6618
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015411.5"
                     /locus_tag="C2865_RS18865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_157963798.1"
                     /transl_table=11
                     /translation="MTVENTRDVAVLGLGEMGAAIAGALLAAGHRTTVWNRTPEKAEEA
                     VAGGARRAATVPDAVAAGEVVFISVKGAAAVRKILEEAGGALAGRTVVNLTDGTSAEAR
                     ETARLAAGSGAEYLHGQIMTIVPGIGHPEAVVFFGGEQAVYDRHRPLLDLLGGKGTLVA
                     ADPGVPVLYGMSVHGIMWGLLNGFLHAAALLTDEGVELKRFLDQAAPSLAALMSFLPSI
                     ADEVEHSRHAAEYGALRHHHPSVDDLLRESRDRGVDDRLPAHTLSLVARALADGHADDS
                     YSRLVDAFRTP"
     gene            complement(6758..7297)
                     /locus_tag="C2865_RS18870"
     CDS             complement(6758..7297)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2865_RS18870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_106400059.1"
                     /transl_table=11
                     /translation="MANRSYLYAADSLPTEQGVPRPVRCVSEHNWSIPLAHLLLAGHEP
                     AVVPSMIWNHRICVAADYAAGADLLTALLRLVGEGEVDDREGFDDLAARTALHLEKQRS
                     RHFLLEPGEIFSINEEDLATAAQSLIDVEIDIAVTRARAALDGRETAWLEELRKDWSTP
                     FASFYADHLYYSFPDD"
     gene            complement(7378..7998)
                     /locus_tag="C2865_RS18875"
     CDS             complement(7378..7998)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017596625.1"
                     /locus_tag="C2865_RS18875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_106399799.1"
                     /transl_table=11
                     /translation="MESAVGRTTDKRLLRGARTRELVLRHAVDLASLEGLENISFGRLA
                     AEAGVSKAGVQTLFKSKEALQVAAVEHARRMFIDAVIRPARSAPPGAARLRALLDRWVE
                     YATAPLFAGGCFRAANLAGFDSRPGPVRDALFRDQQEWTETLAGELRQAVAAGEIADLD
                     APLAAFQIDALLCAANTALRMGDDDAVGKVRRVVEGMLAPPRP"
     gene            complement(8200..9945)
                     /locus_tag="C2865_RS18880"
     CDS             complement(8200..9945)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="C2865_RS18880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_198653417.1"
                     /transl_table=11
                     /translation="MGLREMLGLLAGQRGAAGGALALALAASGLGLVQPLLVKRVIESA
                     GSGPVAWGAVVALVVLCLTQALTEGGVRYALARAGEAVVLGVRLRLIDRLLRLRMPVYD
                     RRRLGDLISRAGTDTTALRQVVATGFTDAVTGCFGLAGAVALMVWLDPVLFLLVAAPVA
                     VACSVLWLALRRVRAASLAGQTATGELAADLERALGAIRTVRACRAEDREAGRIARRAH
                     DAYTANVRMARYDAAVAPAGDLAINGSFLLVLLIGGMRVASGAGSIADLVAFLLYMVYL
                     AGPLGSVFEAASVLQQATGAVHRINEVLAWPREGSGSAVPPTACENTPVLEFRDVWFGY
                     EPERPVLRGVSFQVPDRGHLALIGPSGAGKSTVFALIERFYDPGRGRILADGADLRRLD
                     RAAHRAGIGLVDQDCPILHGTLRDNLLYARPEAAGADLERVIGLANLSGLVTRLPLGLD
                     TPVGERGAALSGGERQRVAIARALLARPRLLLLDEPTAHLDAENEAALRRTIDQAAAEC
                     SLIVIAHRFTTIRTATRIIVLDQGAVTASGTHHDLMASSSYYRGLAAEWTGSGSESTAS
                     LALPD"
     gene            complement(10001..10429)
                     /locus_tag="C2865_RS18885"
     CDS             complement(10001..10429)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017559151.1"
                     /locus_tag="C2865_RS18885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_106399800.1"
                     /sec_met_domain="PF13471 (E-value: 4.3e-26, bitscore: 86.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALHRPTGIPAGRRIAARGAVVSARLLALLPPRRIRWILAL
                     LSRGAVPAAHDQAKAARDAVLAVSLVCLGPQGCLPRSLATVLLCRMSGTWPTWCVGVRT
                     MPPFGAHAWVEADGRMVGEGTPDGYLSPLLSVPPRHER"
     gene            complement(10426..10683)
                     /locus_tag="C2865_RS18890"
     CDS             complement(10426..10683)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291591.1"
                     /locus_tag="C2865_RS18890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_106399801.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.4e-26,
                     bitscore: 86.6, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 9.9e-17, bitscore: 56.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLRLRPGVSTADTSYGTVLLDERSGEYWQLNPTGALIVRLMLAG
                     AGPERTAAALAEEFEVEEPRALRDVTALLEELRSARLVIS"
     aSDomain        complement(10432..10677)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C2865_RS18890_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.30E-27"
                     /identifier="RREFam002.1"
                     /label="C2865_RS18890"
                     /locus_tag="C2865_RS18890"
                     /protein_end="84"
                     /protein_start="2"
                     /score="86.6"
                     /tool="antismash"
                     /translation="LRLRPGVSTADTSYGTVLLDERSGEYWQLNPTGALIVRLMLAGAG
                     PERTAAALAEEFEVEEPRALRDVTALLEELRSARLVI"
     gene            complement(10696..12546)
                     /locus_tag="C2865_RS18895"
     CDS             complement(10696..12546)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="C2865_RS18895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_106399802.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.4e-44, bitscore:
                     147.8, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPERFGMPGHGESHFVVLPDREAALAVAPAFRSPGSRVLPHPSGR
                     PWLVGRWPDDQITVAEAGNTRLAVIGSCPADTARLTREAGRLTDPAGLGRLARSLPGSF
                     HLVAALDGRLCVQGTASGLRLVFHARVNGVTVAADRADVLASLLGAEPDVRQIAVRLLW
                     PVPHPMLRTSLWQGVQSVDPGHRLTVLPDGLTFRQDRWWAPPEPVRSLAEGAVDVRSAL
                     AEAVEARTRGGGTVSCDLSGGLDSTSLCFLAARGEARVIAGTWPGLDPADDDLPWALRA
                     AAHLPEVEHAVWPVEESPLVYADLLEIDDPLDEPTIGVMDRARMLGHVPRLVAKGSRLH
                     LTGIGGDHVAWCSEAYYHRLLRRRPLLALNRLRGFGSLFNRPAGDTARALADNRSYRRW
                     LADSAADLRRPPPSSAANALGWGTAPRMFDWVTPEAVREAGEAVREAAATATPLSSDRG
                     LHVDLYAIHECTRIIRQWEQMSTRAGLPMASPYLDDRVIEACLAVRPQDRVTPWRYKPL
                     LVAAMHGIVPDECLRRSSKATAALDASAGLRAHREDLSALWSESRLAELGLVDVRRLKE
                     LADRPATPALREAILYSTIGCEVWLRTLTARGSRHPVSRP"
     gene            complement(12571..12678)
                     /locus_tag="C2865_RS18900"
     CDS             complement(12571..12678)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039305.4"
                     /locus_tag="C2865_RS18900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_198653418.1"
                     /transl_table=11
                     /translation="MQRYEPPALVASGTFRKVTGLLGKNGNDRLILSKN"
     misc_feature    complement(12831..12844)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.77"
                     /tool="antismash"
     misc_feature    12937..12952
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    12941..12950
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.29"
                     /tool="antismash"
     gene            complement(13226..14389)
                     /locus_tag="C2865_RS18905"
     CDS             complement(13226..14389)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012851438.1"
                     /locus_tag="C2865_RS18905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="low temperature requirement protein A"
                     /protein_id="WP_232835696.1"
                     /transl_table=11
                     /translation="MRDRTAATSTKVSFFELFFDLVFVFAVTQLSHRLLGELTPGNALQ
                     TGLLLLAVWWCWMYTTWATNWFDPDHPVFRMVLTGVMLAGLLMATAIPEAFEERALWFA
                     LGYTAVQVGRTLYGVLVTRGTPLGPTFQRILCWFVPSCALWIAGGTLGGTALVALWVAA
                     ALIDLAGPSSGYFVPGLGRSATSDWSSIDGAHMAERCQLFVIIALGESVLLTGVTYAKH
                     PYGAAATAAFALAFLSSVAFWWIYFDRTAEASAEAIATCPDPGRVGRNAYTYGHLPIVA
                     GIIVAAVADELVIAHPTGHTTAGTAAAVLGGAGLFLTGHLLFTRTVFGHWSRPRLTALA
                     LLAALAFAHPLLSPILLAFAALLVLAMVPVWDLASSRRTEEPEVDFD"
     gene            complement(14514..15953)
                     /locus_tag="C2865_RS18910"
     CDS             complement(14514..15953)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012092670.1"
                     /locus_tag="C2865_RS18910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_232835697.1"
                     /transl_table=11
                     /translation="MVIAAAQLMVVLDGTITNIALPSIQTDLGMSSSGLAWVINSYALA
                     FGGLLLLGGRSGDLFGRRRMFRVGLAVFTVASLLGGLAQNDVQLIAARILQGVGAAIAA
                     PTALSLITVNFPEGRPRNKAMGVYAAMAGIGSTVGLLLGGVLTDYLDWRWVMFVNVPIG
                     LVVLAGTKVLAEGERNTGGLDVPGAVTGTGGLLALVYGITRGGEDGWTDSLTLASGAAA
                     LVLLAVFLVIQTRSAHPMMPLRLFADRNRAGAYATVMFIGAGMFATFYFLTLYLQQVHG
                     YSPVRTGLAYLPFSLGMGVAAGVGTQLVTRLAPRLIAGPGLVVAALGMFWFSALEPGSP
                     YLTHILPAMFITAVGLGVSFVPMTLGAVSKVRDQDAGIASALLNTTQQIGGALGLAALS
                     TISAGVANGDLPHASERFFQALALGDLPLLKQASEALTHGYTAAFLVASTLFVAALVIV
                     AAAVNAPRQEQSENGTAVHMG"
     misc_feature    complement(16019..16033)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.64"
                     /tool="antismash"
     misc_feature    16049..16064
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.35"
                     /tool="antismash"
     misc_feature    16064..16077
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.03"
                     /tool="antismash"
     gene            16392..>17795
                     /gene="gndA"
                     /locus_tag="C2865_RS18915"
                     /pseudo=""
     CDS             16392..>17795
                     /GO_function="GO:0004616 - phosphogluconate dehydrogenase
                     (decarboxylating) activity [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="gndA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017599842.1"
                     /locus_tag="C2865_RS18915"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NADP-dependent phosphogluconate dehydrogenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTATSRIGVTGLAVMGANLARNIARRGVPVAVHNRTAERTRKFMK
                     DHGDEGAFTAAETVEDFVGALERPRRIIIMVKAGGPVDTVIDELVPLLEEGDILIDGGN
                     SHFTDTRRRVERCARDGLRFIGAGVSGGEEGALLGPSIMPGGDRAAYAEVEEILTGIAA
                     QVDGTPCCTYVGPDGAGHYVKMVHNGIEYADIQLIAEAYDLLRNVAGLDVPVIARTFEE
                     WNSGDLESFLVEITAKVLAKTDERTGGPLVDVIVDEAEQKGTGRWTAQDALELGVPLTG
                     ITEAVYARTLSSLREERGRASAVLRGPVPEDGSVREELVDDIRQALYASKVVAYAQGFA
                     QMHAASRAYGWDLDLGAMATIWRGGCIIRARFLDRIRDAYAEHPDLENLLTVPYFTEAV
                     ANAQDAWRRVVTTATERGVPIPAFSSSLSYYDGYRRERGPASLIQGLRDFFGAHTYRRV
                     DAEGAFHTRW"
     gene            complement(17939..18088)
                     /locus_tag="C2865_RS40080"
     CDS             complement(17939..18088)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2865_RS40080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_198653419.1"
                     /transl_table=11
                     /translation="MASVITRIRRFLNSPQGRQARMRAEQLARDPRHQAKARGLLQRFR
                     GRRH"
     gene            complement(18213..19607)
                     /locus_tag="C2865_RS18920"
     CDS             complement(18213..19607)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853068.1"
                     /locus_tag="C2865_RS18920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_106399805.1"
                     /transl_table=11
                     /translation="MTTAAYERLAGTLRGELVRPEDPGYDQARAVYNAMIDRRPAAIAR
                     CRDVADVIACVRFAREHDVELSVRGGGHNAGGLGVWDDALAVDLSAMRSTTVSPEQHRV
                     RVDGGCVWGDVDHATVEFGMATPSGFVASTGVGGLTLGGGIGHLSRRFGLTVDNLLSAD
                     VVLADGSFVTANDNSHDDLFWALRGGGGNFGVVTSFTFRCHDIGEHGTIIGGPVMYDLV
                     DTADVMRWYRDLIPTLPETLSGWFGLAAVAPAPPFPEELWGRKVCMVMWCYTGPHDRAD
                     EVLEPVRSYGSPLLTGLHPMPFDVLQSSFDALLPPGLQWYWKADFFEEISDAAIDVHCR
                     YGELLPTGLSTMHLYPIDGAVARVPSDATPFAYRDGGWAGVIVGIDPDPANAPRITQWA
                     RDYWSDLHATSAGGAYVNFLMNNEGQDRIRASYRGNYDRLSEIKARYDPDNVFHINQNI
                     RPASLV"
     misc_feature    19688..19702
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.29"
                     /tool="antismash"
     misc_feature    complement(19691..19704)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.57"
                     /tool="antismash"
     gene            complement(19697..21379)
                     /gene="cydC"
                     /locus_tag="C2865_RS18925"
     CDS             complement(19697..21379)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0055051 - ATP-binding cassette (ABC)
                     transporter complex, integrated substrate binding [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0033230 - ABC-type cysteine transporter
                     activity [Evidence IEA]"
                     /GO_function="GO:0050456 - cystine reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0033228 - cysteine export across plasma
                     membrane [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cydC"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR02868.1"
                     /locus_tag="C2865_RS18925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiol reductant ABC exporter subunit CydC"
                     /protein_id="WP_157963799.1"
                     /transl_table=11
                     /translation="MRREVSWWRLAGAVGAGALAQWCGLGLAAASAWMIARAAERPPLV
                     ALGLVIVAVRGCAVFKGVFRYAERLAGHDAALESLAGVRVRLFTALGRGRWRGGDAAAL
                     NGMLSDVDCVQDLLLRCLLPASGALLGGGAGLALVTVVHPRSGAVLAAGLLAAGVLLPL
                     AAALASCRTGEAVSAQRDALAAAGLDLVEGADELTVHGAAAGARADAGRAAARLAVLER
                     RDSLVADTVAALGLVVQTATALAVLLAVREAGTVTTATLVLTALVAVELVLPLGEAARQ
                     GVTAWPAARRIAALLRAPEAGGPADPRPVPPGPLRVELLGASVRYGARTALEQVDLRVE
                     RGRRIAVVGASGAGKSTLLAALSGAVPLDRGTALLAGLPLASYAPDDVRRAVCGLAQDA
                     HVFATTVRANLLLARPGATDADLTGVLRRARLLDDVEALPLGRDTPVTPQSLSGGQRRR
                     LLLARALLADPGVLLLDEPTEGLDAATADELVRELFTSPGGGTVVLVAHRLAALRHADE
                     IVVMDGGRVAQRGTHTALAAVPGPYRDLLEIESLTTGGEMARI"
     misc_feature    21732..21746
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.79"
                     /tool="antismash"
ORIGIN
        1 catgcacgag gtggtccgcg gcggcggcct cggcgccgac tccgaagtcg ccttcatgct
       61 cgaccagtgc cacaacatcg agccgaagat ccagggccag atccggtccg tcatgaacgt
      121 ccaggaggcc accgccaagg ccctcctggt cgacaccgcg gcgctgaagg ccgcgcagga
      181 ctccggcgac gtgctcggcg cgaacgccgt cctgatggac gcctacaaca ccgatgtccg
      241 cccgctgctc gccgagtggc gcgaggccaa gggcctggcg ggcgacccga tcgccgcgta
      301 caaggcgtcc gggtacctcg agaagatctc cgccgagcgt gtcggcggca accaggccgg
      361 ctggggggcc tgattctgat gagcgatgct gtgaacaccg ttgtgcagga cctgctgaac
      421 cgttgtcacg agctgggcgc cgacccgcgg aacaccaact acgcgggagg gaacgcctcc
      481 gccaagggcg tcgagaccga cccggtcacc ggcgagcccg tcgacctcat gtgggtcaag
      541 ggctccggcg gcgacctggg caccctgaag gcgtcgggcc tggccgtgct gcgcctggac
      601 cggctgcgcg ccctggtgaa cgtgtacccg ggggtggagc gcgaggacga gatggtcgcc
      661 gcgttcgact tctgcgcgca cggcaagggc ggcgccgcgc cgtcgatcga cacggccatg
      721 cacggcctgg tcgaggcggc gcacgtggac cacctccacc cggacagcgg catcgcgatc
      781 gcgaccgccg aggacgggga ggagctcacc cggaggatct tcggggacag ggtggcgtgg
      841 gtgccgtggc ggcgcccggg attccagctc gggctggaca tcgcagcgat caaggcggag
      901 aacccgcagg cgatcggcgt gatcctgggc ggccacggca tcaccgcgtg gggggagacc
      961 tcccaggagt gccaggccaa ctcgctggag atcatcggca cggccgaggc gttcctggcc
     1021 gagcacgggc gtccggagcc gttcggtccg gtcatccccg gctacgagcc gctgccggag
     1081 gccgagcgcc gcgcccgcgc cgccgagctg ttcccgctgg tccgcgggct cgcctcgacg
     1141 gacaagccgc aggtcggcca cttcaccgac gatgacgccg tgctggactt cgtctcccgc
     1201 gccgagcacc cgcgcctggc cgcgctcggc acgtcctgcc cggaccactt cctgcgcacc
     1261 aaggtctcgc cgctcgtcct ggacctggcg cccggcgccc cgctggacga ggtcaaggcc
     1321 cggctgaagg aactccacgc cgcctaccgc gcggactacg ccgcctacta cgaccgccac
     1381 gccacgccgg agtccccggc gatgcgcggc gcggacccgg cgatcgtgct ggtgccgggc
     1441 gtcggcatgt tctccttcgg cgcgaacaag cagaccgcgc gcgtcgcggg cgagttctac
     1501 gtcaacgcga tcaacgtgat gcgcggcgcc gagtcggtgt cgaggtacgc gccgatcgag
     1561 gagtcggaga agttccgcat cgagtactgg tcgctggagg aggccaagct ccagcgcatg
     1621 cccaagccca agccgctcgc cacccgcgtg gcgttcgtga cgggcggcgg ctcgggcatc
     1681 ggcgcggcca ccgcccgccg cctggcctcc gaaggcgcgt gcgtcgtcgt ggccgaccgc
     1741 gatctggccg ccgccgagaa ggtcgcggct gagctcgggg cgggcgcgct gcgcgcctcg
     1801 gacgtggcga tcgcggtggc cgccgacgtc accagcgagg acgagatcaa ggcggcgctg
     1861 gccgcggcgg tcctggcctt cggcggcgtc gacctggtgg tcaacaacgc cggcctgtcg
     1921 ctgtccaagc cgctgctgga gaccaccgtc gccgactggg acctgcagca cgacgtcatg
     1981 gcgcgcggct cgttcctggt ctcccgcgag gccgcccgca tcatgatcga gcaggcgatg
     2041 ggcggcgacg tcgtctacat ctcctccaag aactcgatct tcgcgggccc caacaacatc
     2101 gcctacagcg cgaccaaggc cgaccaggcc caccaggtcc gcctgctggc ggccgagctg
     2161 ggcgagcacg gcgtccgcgt caacggcatc aaccccgacg gggtcgtccg cggctccggc
     2221 atcttcgcct ccggctgggg cgccaaccgc gccgccgtct acggcgtcga ggaggagaag
     2281 ctcggcgagt tctacgccca gcgcaccctc ctcaagcgcg aggtcctgcc cgagcacgtc
     2341 gccaacgccg tcttcgccct caccggcgga gacctgaccc acaccaccgg cctccacatc
     2401 cccgtggacg ccggcgtcgc cgcggccttc ctgcgctgac gcccaccgcc cgggccgcct
     2461 ccggccgcgg cccgggcgcg ctccaccggc cggtccgccc cggccgttcc aggccgtccc
     2521 ggacggcggc gttctcgggg gacgccgccg ctcctttctc accctgcctt cgtgaaaccg
     2581 aggttcggca tgcccgaaaa cagccccgtc ttctcccgac gtcgcttcct tcagaccgcc
     2641 gccgtggccg gcaccgccgt cgccgtcgcg ggtggtcccg gcggtacgcc cgccgcgctg
     2701 gccgacgccg gttccaccga tttccccgca ctccccgcct cggtacggcc ctggttccgc
     2761 tggtggtggc cggacggcct cgtcgacccg gccgagatcg cccgcgagat cgaccagatc
     2821 gccgacgccg ggttcggcgg tgcggagatc gccgcggtcc accacagcat caaggacaag
     2881 tcggtgctcg acccggccgg acacggctgg gggagcgccc cctggatcgc cggtgtggaa
     2941 gccgcgttgg agcgtgccaa caggcgcggc atcggcatcg acctgacgct cggcccggcc
     3001 tggccttccg ccaccccgac gatcacgccc gacagcgcgg cggcctgcaa ggagctggcg
     3061 tacggcgcgg tcaaggtcgc cgccgggacc gagtacaccg gccccgtgcc gccgcccctc
     3121 gtcgccgccc acggcgacgt cgaggagaag ctccggtacg tgcacgcgat gcgcgtcaac
     3181 gccgcgaaca acacgcgcaa ggaggtcgga ctcgagcccg cctcccacgt cgccctgttc
     3241 gatgccgtcg ccgacgggca gatctcctgg accgcgcccg ccgacggcga ctggtacctg
     3301 ttcgcctact gggagcgcgg ttcgggccag caaccggagt ccggcccgca caccgccccc
     3361 gagtcctacg tcgtcgacca cttcagcgcc gagggcaccc gcgccgtcat cgacttctgg
     3421 gaggagtcgg tcctgaccag ggagctgcgc aggctgctca agcgcaacgg cggcgcgctg
     3481 ttcgaggact ccttcgagct ggagaccgac gccctgcagt ggacgccgaa gatcgacgag
     3541 gagttcgaga agcggcgcgg ctacgcgctg tggcccgtcc tgccggcgat cctgctgaac
     3601 aacgagaaca ccgtcttcgc cttcgacgcc gtgctcagcc gcgaggtccg gcacgactac
     3661 tgggagaccg tggcgaacct gttcgacgag cggcacttcc ggccgctgcg cgactgggcg
     3721 caccggctcg gcatgaagct gcgcgcccag ccttacgggc tgaacaccga cgccatcgcc
     3781 tcgtccgcga tcctggacgt caccgagggc gagtcgctgg gcttcaagaa cctcgacgac
     3841 taccgggcgc tggccggcgg gcgcgacatg ggcggccacc tcgtcatgtc gtccgagacc
     3901 ggcgcctacc agggcggcgc ctacgccacc acctggaaga agatcatccg gacgatgtcc
     3961 ggcgcgtacg cggcgggcct gaaccagacg gtgttccacg gcttctccta cgccaccgcg
     4021 cccggcgtgc agtggcccgg cttcgcggcg ttcacgccct acgacggcaa ggtcggcttc
     4081 tccgagtcgt gggggccgcg ccagcccagc tggacccaca tcaacgatat ctccgactac
     4141 ttcgcgcgga tccacgccgt cacccaggcc ggctccatgc gcgccgacat cgccgtcttc
     4201 cggcagaccg gctactccaa gaccggtatc ggcgtcggct ggctgacctc gaacggcgtc
     4261 ccgctcggct ggacccacca gatgatcagc gcgcccctgc tcgacctgcc gtccgcgcgg
     4321 gtccgcggcg ggcggctggc tcccgacggc ccggcctaca aggcggtcgt catcgagggc
     4381 gaccggttct acggacgcgc cgccaccctt ccgctggacg tggcgcggaa gttcctctcc
     4441 tacgccaagg cgggcctgcc gatcgtcttc gtcggcgagt ggtccgccgc gaccatcccc
     4501 ggcaaggccg tcgggaacga gaacgagcgg ctcagggcgg ttctcaccga gctgttcgcg
     4561 cacccgaagg cacgcgtcgt cacgaccgag gcggaactgc ccgccgcgct ggccgacctc
     4621 ggcgtcacac ccgacgcccg gtacgccgcg gcctcgacgc tgctcaacgc ccaccgcgtc
     4681 gacaagggca tggacctgta ctacctgtcc aacggcaagc acgccgagag cagcaagggc
     4741 gtcgtcgcca tcgaccacga ggtgacgttc acccgcagcg gccgcgaccg cgtcccgtac
     4801 ctcctgaacc tgtggagcgg cgaggtcgag cgcatcgccc gctacaccga gaacggcgac
     4861 gacgtgaccg tccgggtggc cttgcaggtc aaccagacct gcgcggtcat cctggcgcgc
     4921 agggcctggc tgcgggaggc gagcaccggc ctgcacgcgg tgtccaccac ggccgactcc
     4981 gtccactacc gggggagccg ccgcctgcag atccgcgcca aggcccccgg cacctacacc
     5041 acggccctct cggacgggcg gaccgtggcc acggaggtcg aggcggtgcc cgcggtcatc
     5101 acccccgcgg cctggaccgt gacggccgat tcctggctgc ccggcgcgac ccccgtggag
     5161 acggtgaagg agaaggtgac cgcggagctg accaccctgg ccccctggtc gaccatcccg
     5221 gccctccagg acgtctcggg cgtcggccgc tacaccacca ccttcgccct cgacgcctcc
     5281 tggaccgacg acaacggcgc ctacctggag ctcggcgagg tcttcgacac cgtacgggtc
     5341 accctcaacg gcaaggcgct gccgccggcc gacctcatca acccggtcct cgacctggac
     5401 ggtcacctca agaagggcgt caacaccctg gtcgtcgagg tcaccacgac cctgaacaac
     5461 cgcctccgcc tgtccgatcc gggcgtctac ggcgccaacc cccgccaggc ctacggcctg
     5521 accggtcccg ttcgtatcgt cccctacacg aagaagaatc tctgacgctc tgccagcgga
     5581 cttctgagcc ggaagaagcg ggacggaggg gtgccgttcc gcttcttctt cgggtcgggg
     5641 gccgaagagc ttgacttaaa gttaagttaa agttttagca tctcctgtga tcgacgagcg
     5701 gccgtggacg cggccgccgc cgctgaacgg gagaacgaga tgactgttga gaacacgcgg
     5761 gacgtggcgg tcctgggcct cggcgagatg ggtgccgcga tcgcgggcgc gctcctggcg
     5821 gcagggcacc ggaccacggt gtggaaccgc actccggaga aggccgagga ggcggtggcc
     5881 gggggcgcga ggcgggcggc gacggtaccc gacgccgtcg ccgcgggtga ggtggtgttc
     5941 atcagcgtca aaggcgctgc cgccgtccgg aagatcctgg aggaggcggg tggcgccctc
     6001 gccggtcgca cggtggtgaa cctgacggac ggcacgtccg ccgaggcgag ggagacggcc
     6061 cgcctcgccg ccggatcggg cgcggagtac ctgcacggcc agatcatgac gatcgtcccg
     6121 ggcatcggcc acccggaggc cgtggtgttc ttcggcggag aacaggccgt gtacgaccgc
     6181 caccgtccgc tgctcgacct cctgggcgga aaggggaccc tggtggcggc cgaccccgga
     6241 gtgccggtcc tttacggcat gtccgtgcac ggcatcatgt ggggtcttct gaacggcttc
     6301 ctgcacgccg ccgccctgct gacggacgag ggcgtcgagt tgaagcgctt cctcgaccaa
     6361 gccgccccgt ccctggcggc gctcatgtcg ttcctgccgt cgatcgccga cgaggtcgag
     6421 cactcccggc acgccgcgga gtacggcgcc ctgcgccacc accacccgtc cgtcgacgac
     6481 ctcctccgcg aaagccgcga ccggggcgtc gacgaccggc tccccgccca caccctgtcc
     6541 ctggtcgccc gggccctcgc cgacggccac gccgacgaca gctactcccg cctggtcgac
     6601 gccttccgca ccccctgacg cctgggccgc ccggcgcctt tgggcgggcg tcccgatcgg
     6661 tccggccgcg cctctcgtac ggccggatcc acgagccgtc gggagggcca tccgggacga
     6721 tcgccgaagg cggcacgggg cgcgtgggag cggatcgtca gtcgtcgggg aaggagtaat
     6781 acaggtggtc ggcgtagaag gaggcgaaag gcgtcgacca atccttgcgg agctcctcca
     6841 gccaggccgt ctcccggccg tcgagggcgg cccgggcccg ggtgacggcg atgtcgatct
     6901 cgacgtcgat caggctctgg gcggccgtcg ccagatcctc ttcgttgatg ctgaagatct
     6961 cgcccggctc cagcaggaag tggcgggacc gctgcttctc cagatgcagg gcggtgcggg
     7021 cggccaggtc gtcgaagccc tcccggtcgt cgacctcccc ctcgcccacc aggcggagca
     7081 gggcggtgag aaggtcggcg cccgcggcgt agtcggcggc cacgcagatc cggtgattcc
     7141 agatcatcga cggcacgacg gccggttcgt gcccggccag gagcagatgg gccagcggga
     7201 tgctccagtt gtgctcggag acgcatctga ccggccgggg gacgccctgc tccgtcggca
     7261 gggagtcggc cgcgtaaaga taggaacgat tcgccacgga cacgacttta gccggaagat
     7321 cacccaagcc ggttgatctt gtcgcgaccg tccggcgggc gtccgcaccg ggcggcgtca
     7381 gggccggggc ggcgccagca ttccctcgac gacgcggcgg accttgccga ccgcgtcgtc
     7441 gtctcccatg cgcagggcgg tgttcgccgc gcacagcagg gcgtcgatct ggaaggcggc
     7501 gagcggggcg tccaggtcgg cgatctcgcc cgccgccacg gcctggcgca gctcgcccgc
     7561 gagggtctcg gtccactcct gctggtcgcg gaacagcgcg tcccggaccg ggccgggcct
     7621 gctgtcgaag cccgccaggt tcgcggcgcg gaagcagccg ccggcgaaca gcggagccgt
     7681 ggcgtactcg acccagcggt cgagcagcgc gcgcaggcgg gccgcaccgg gaggcgccga
     7741 ccgggccggg cggatgacgg cgtcgatgaa catgcgccgc gcgtgctcga cggcggccac
     7801 ctgcagcgcc tccttggact tgaagagggt ctggacaccg gctttgctga ccccggcctc
     7861 ggccgcgagc cgtccgaagc tgatgttctc gagcccttcg agcgaggcga ggtcgaccgc
     7921 gtgccgcagc accagctccc gtgtgcgggc cccgcgcaga aggcgcttgt cggtggtacg
     7981 gcccacggca ctctccatac ggtcgaccgt atcccgaccc ggagacctcg tccgccgccc
     8041 catgccgcac cggcgccgcc gtcacggacc cgcggggacg gaggcgaccc ccggccggta
     8101 cccgtgggca tcggccgggg gccgctcgcc tgcggtcttc gcatccgcgg attcgcctgc
     8161 accactttcc cgtcccgtac ggcggcggat ccgtgccctt caatcgggga gagccaggga
     8221 tgcggtgctc tcggaaccgg agccggtcca ttcggcggcg agcccgcggt agtaggaact
     8281 ggaggccatc aggtcgtggt gggtgccgga cgcggtgacg gcgccctggt cgagcacgat
     8341 gatccgggtg gcggtgcgga tggtggtgaa gcggtgcgcg atgacgatga gggagcactc
     8401 ggcggcggcc tgatcgatcg tgcggcgtag cgcggcctcg ttctcggcgt ccaggtgggc
     8461 ggtcggttcg tcgaggagca gcaggcgggg gcgggccagg agggcgcggg cgatcgcgac
     8521 ccgctgacgc tcaccgccgg acagcgccgc cccgcgttcg cccaccggag tgtccagacc
     8581 cagcggcagc cgggtgacca gtccgctgag attggccagc ccgatcacgc gttcgagatc
     8641 ggctccggcc gcctcggggc gggcgtagag gaggttgtcg cggagcgtgc cgtgcaggat
     8701 cgggcagtcc tggtcgacca ggccgatccc ggcccggtgg gcggcgcggt ccagccggcg
     8761 caggtcggcg ccgtccgcca ggatccggcc gcggccgggg tcgtagaagc gctcgatcag
     8821 cgcgaagacc gtcgacttcc cggctccgga cgggccgatc agcgcgaggt gcccgcggtc
     8881 gggaacctgg aaggacaccc cgcgcagtac cggccgctcc ggctcgtagc cgaaccacac
     8941 gtcgcggaac tccagtaccg gggtgttctc gcacgctgtc ggcggcaccg ctgagccgct
     9001 cccctcgcgg ggccaggcga gcacctcgtt gatccggtgc accgcgccgg tcgcctgctg
     9061 caggacgctg gccgcctcga agaccgagcc gagcggcccg gccaggtaca ccatgtacag
     9121 caggaaggcg acgagatcgg cgatcgaccc cgcaccggac gcgacacgca tcccgccgat
     9181 gagcaggacc agcaggaacg agccgttgat cgccagatca ccggcgggcg cgacggccgc
     9241 gtcgtaccgg gccatccgta cattcgcggt gtaggcgtcg tgggcccgcc gcgcgatgcg
     9301 ccccgcctct ctgtcctcgg cacggcaggc ccgtacggtg cggatcgcgc ccagcgcccg
     9361 ttcgaggtcg gcggccagct caccggtcgc ggtctggccc gccagagatg ccgcccggac
     9421 cctgcgcagg gcgagccaga gcaccgagca ggcgacggcg accggtgccg cgaccaacag
     9481 gaacaggacc gggtccagcc agaccatcag cgccacggcc ccggccagcc cgaaacagcc
     9541 tgtcaccgcg tcggtgaacc cggtggcgac cacctggcgc agcgcggtgg tgtcggtgcc
     9601 ggcccgggag atcaggtcac cgagccggcg ccggtcgtac accggcatcc gcaaccgcag
     9661 cagccggtcg atcagcctga gccggacgcc gagcaccacc gcctcaccgg cgcgcgccag
     9721 ggcataccga acacccccct cggtcagcgc ctgcgtgagg cacagcacga ccagcgccac
     9781 cacggcgccc cacgccaccg ggccggagcc ggcactctcg atcaccctct tgaccagcag
     9841 cggctgcacc aaccccagtc ccgaggcggc cagcgccagc gccagcgcgc ccccggccgc
     9901 cccgcgctgc ccggccagca gccccagcat ctcgcgcagt cccacccgac ggccctcgac
     9961 cctcccgtct tcggcccgat cgcctccgat gccgcgcggg tcaccgctca tggcgagggg
    10021 gcacggacag cagggggctg aggtagccgt cgggcgtccc ttcgccgacc atccggccgt
    10081 ccgcctcgac ccaggcgtgc gcgccgaacg ggggcatcgt ccggacgccg acgcaccagg
    10141 tcggccaggt gcccgacatc cggcacagca ggacggtcgc caacgaccgg ggaaggcagc
    10201 cctgcgggcc gaggcagacg aggctgaccg cgagcacggc gtcacgcgcg gccttcgcct
    10261 ggtcgtgggc ggcgggcacg gcgccccggc tcagcagtgc caggatccac cggatgcggc
    10321 ggggcggcag cagggccagc aggcgggccg acaccacggc gccgcgggcg gcgatccggc
    10381 ggcccgcggg gatgccggtg gggcggtgga gcgcgctggg cgtcgtcatg agatcaccaa
    10441 ccgggcggat cggagctcct ccagcagcgc ggtcacgtcc cgaagcgccc gcggttcttc
    10501 gacctcgaac tcctcggcca gcgccgcggc ggtccgctcc gggccggcgc cggccagcat
    10561 cagccggacg atgagcgctc ccgtggggtt gagctgccag tactctccgc tgcgctcgtc
    10621 gagcagcacg gtgccgtacg aggtgtccgc ggtggacacc ccgggacgca gtcgcagtcc
    10681 caacgggttc tcctttcagg gacgggacac cggatgccgg gagccgcgcg cggtgagcgt
    10741 gcgcagccag acctcgcagc cgatggtgga gtacaagatc gcctctcgta gggcaggggt
    10801 ggccgggcgg tccgccagct ccttcagccg ccgcacgtcg accagtccca gctcggccag
    10861 gcgggactcc gaccacagcg ccgacaggtc ctcacggtgc gcgcgcaggc cggcggaggc
    10921 gtccagcgcg gccgtggcct tgctgctgcg ccgcaggcac tcgtcgggca cgatgccgtg
    10981 catcgccgcg accaggagcg gcttgtagcg ccacggcgtc acccggtcct gcggccggac
    11041 ggccaggcac gcctcgatca cccggtcgtc gaggtagggg gaggccatgg gcaggcccgc
    11101 ccgggtgctc atctgctccc actgccggat gatccgggtg cactcgtgga tcgcgtagag
    11161 gtcgacgtgc agcccccggt cggaggacag cggcgtggcc gtggcggccg cctcccgcac
    11221 cgcctcgccc gcctcccgca ccgcctcggg ggtgacccag tcgaacatcc ggggagccgt
    11281 tccccagccg agcgcgttcg ccgcggacga aggaggaggg cggcgcaggt ccgcggccga
    11341 gtccgccagc caccggcggt aggagcggtt gtcggccagc gcccgcgcgg tgtccccggc
    11401 cggccggttg aacagggagc cgaagccgcg gagccggttc agcgcgagca ggggccgtct
    11461 gcgcagcagc cggtgatagt aggcctccga gcaccaggcg acgtggtcgc cgccgatgcc
    11521 ggtcaggtgc aggcggctgc ccttggcgac cagccggggc acgtggccga gcatccgggc
    11581 gcggtccatc accccgatgg tcggctcgtc cagcggatcg tcgatctcca gcaggtccgc
    11641 gtagaccagc ggggactcct cgacgggcca gacggcatgc tccacctcgg gcaggtgggc
    11701 ggccgcgcgc agcgcccacg gaaggtcgtc gtcggcggga tcgagtcccg gccaggtgcc
    11761 ggcgatgacc cgggcctcgc cccgggcggc gaggaagcac aacgaggtcg agtcgagccc
    11821 gccggagagg tcgcagctca cggtaccgcc gccccgggtg cgggcctcga ccgcctcggc
    11881 cagcgcggac ctgacgtcga cggcgccttc ggccagggac cgcacgggtt ccggtggtgc
    11941 ccaccagcgg tcctgccgga aggtcagccc gtccggcagc acggtgaggc ggtggccggg
    12001 gtcgacgctc tggacgccct gccacaacga ggtccggagc atcgggtgcg ggacgggcca
    12061 caacaggcgc accgcgatct gccgcacgtc cggttcggcg ccgaggaggg aggccaggac
    12121 gtcggcgcgg tcggcggcca cggtgacgcc gttcacccgg gcgtggaaca ccagccgcag
    12181 accggaggcg gtgccctgga cgcacagccg tccgtccagc gcggccacca ggtggaagct
    12241 gcccggcagg gaccgggcga gccggccgag tcccgccggg tcggtcagcc gcccggcttc
    12301 ccgggtcagc cgtgcggtgt cggcggggca ggagccgatg accgccagcc gggtgttccc
    12361 ggcttcggcc acggtgatct ggtcgtccgg ccagcggccg accagccagg gccggcccga
    12421 gggatggggg aggacgcggg agccggggga gcggaaggcc ggggccacgg cgagcgcggc
    12481 ctcgcggtcc ggaaggacca cgaagtgcga ctcgccgtga cccggcatgc cgaagcgttc
    12541 tggcatgggt cggaccggta tccgttccgc tcagttcttg ctgaggatca gacggtcgtt
    12601 gccgttcttg ccgaggaggc cggtcacctt gcggaaagtt ccggatgcca ccagggcggg
    12661 gggttcgtag cgctgcatga tctccctttc tgaggggacg agagaaggat taagccttcc
    12721 tcgaaccttc atccaacggt ctctgaccag cggatttcgg tagaggagtg caaagggagt
    12781 ttcgcagctc cggcagggct cgtccaatgt cgctattctc ccgatttctc ttttggtcaa
    12841 agatcgactc aagcatgaaa tggtgataaa ggcgcatttg gttactgggt ttcggtggtg
    12901 gggagagtcg ccatggtcga ctaaacaacc gtggtggtga catttttttg gcgctcctgc
    12961 gggccgcgtc tatcgcgcgg taccggattc ccgcgaagcg gagagggcgg cgagacccgg
    13021 tcgcgcttgc atggcgggag gaggcgtgtg cttctgtttc ccgttccgtc gtgtcaaggg
    13081 gagcgggatc atgcggcagt ggtttcggac gggaggcgga cggcaccgtg cggacgggct
    13141 tgaagaggat ggaaggcctc acgccgggat cgttgtgatc gcggctctac gaccggttcg
    13201 cctgatccgg ccgccgcttc ggtgcctagt cgaagtcgac ttcgggctct tcggtgcggc
    13261 gggaggaggc caggtcccag acggggacca tggcgaggac cagcagtgcc gcgaacgcca
    13321 gcaggatcgg ggacagcagc gggtgggcga aggccagcgc ggcgagcagg gccagggccg
    13381 tcagcctcgg gcgggaccag tggccgaaga cggtgcgggt gaacagcagg tgcccggtga
    13441 ggaacaggcc cgcgccgccc aggacggccg cggcggtgcc cgccgtggtg tggccggtgg
    13501 ggtgggcgat gacgagttcg tcggcgaccg cggcgacgat gatgccggcg acgatcggga
    13561 ggtgcccgta ggtgtaggcg ttgcggccga cccggccggg gtcggggcag gtggcgatcg
    13621 cctcggcgga ggcctcggcc gtccggtcga agtagatcca ccagaaggcc accgaggaga
    13681 ggaacgccag ggcgaacgcg gcggtcgccg ccgcgccgta ggggtgcttc gcgtaggtga
    13741 cgccggtgag cagcaccgac tcgccgagcg cgatgatgac gaagagctgg cagcgttcgg
    13801 ccatgtgggc gccgtcgatc gacgaccagt cggaggtcgc ggaacggccg aggccgggga
    13861 cgaagtagcc gctggacggc ccggcgaggt cgatgagggc ggcggcgacc cacagcgcca
    13921 cgagggcggt gccgccgagg gtgccgccgg cgatccacag cgcgcaggac ggcacgaacc
    13981 agcagaggat ccgctggaag gtcggtccga gcggggtgcc gcgggtgacc aggaccccgt
    14041 agagggtgcg gccgacctgg acggcggtgt aaccgagcgc gaaccacagg gcgcgttcct
    14101 cgaacgcctc ggggatggcg gtcgccatga gcaggcccgc cagcatcacc cccgtcagca
    14161 ccatgcggaa gaccggatgg tcggggtcga accagttcgt ggcccaggtg gtgtacatcc
    14221 agcaccacca gaccgccagc agcagcagcc cggtctgcag ggcgttcccc ggcgtcagct
    14281 ccccgaggag ccggtgggac agctgggtga cggcgaacac gaagacgagg tcgaagaaaa
    14341 gctcgaaaaa ggagactttc gtcgaggtcg cggccgtgcg atcgcgcaag ggggatggca
    14401 ttccctcaat ttaacgggtg aggacccggg tctcgcggcg tcgtggttcg cctggaaaga
    14461 acacgggtcc cgcccttcgg agaaggacgg gacccgtggg agagggccgg gggtcagccc
    14521 atgtggacgg cggtgccgtt ctcggactgc tcctggcggg gggcgttgac ggcggcggcg
    14581 acgatgacga gcgccgcgac gaacagggtg gaggccacca ggaaggcggc ggtgtagccg
    14641 tgggtcagcg cctccgaggc ctgcttcagc agggggaggt cgccgagggc cagggcctgg
    14701 aagaacctct ccgaggcgtg ggggagatcg ccgttcgcca cgccggcgga gatggtgctg
    14761 agcgcggcga ggccgagggc gccgccgatc tgctgggtgg tgttgagcag cgcggaggcg
    14821 atgccggcgt cctggtcgcg gaccttgctg acggcgccga gggtcatcgg gacgaagctg
    14881 acgccgagcc cgacggcggt gatgaacatc gccgggagga tgtgggtgag atacggcgag
    14941 ccgggctcca gggcggagaa ccagaacatg ccgagcgcgg cgaccaccag gccgggcccg
    15001 gcgatcagcc ggggggccag gcgggtgacg agctgggtgc cgacccccgc ggcgacgccc
    15061 atgccgaggc tgaagggcag gtaggccagg ccggtccgga cggggctgta gccgtggacc
    15121 tgctggaggt agagggtgag gaagtagaag gtggcgaaca tgcccgcgcc gatgaacatc
    15181 acggtggcgt acgcgcccgc gcggttgcgg tcggcgaaca ggcgcagcgg catcatcggg
    15241 tgggcggaac gcgtctggat caccaggaag acggcgagca ggacgagcgc ggcggcgccg
    15301 gaggccagcg tgagggagtc cgtccagccg tcctcaccgc cccgggtgat gccgtagacg
    15361 agggcgagga ggccgccggt gccggtgacg gcgccgggga cgtccaggcc gccggtgttg
    15421 cgttcgcctt cggccaggac cttcgtcccg gcgagcacga cgaggccgat ggggacgttg
    15481 acgaacatga cccagcgcca gtccaggtag tccgtcagca cgccgcccag cagcaggccg
    15541 acggtggagc cgatgcccgc catcgcggcg tagacgccca tcgccttgtt gcgcggcctg
    15601 ccctcgggga agttcaccgt gatcagcgac agcgcggtcg gcgcggcgat cgcggctccc
    15661 accccctgca ggatccgggc ggcgatcagc tgcacgtcgt tctgcgccag gccgcccagg
    15721 agcgaggcga cggtgaagac ggccagtccc acgcggaaca tgcggcggcg gccgaagaga
    15781 tcgccggacc tgccgcccag cagcagcagc ccgccgaagg cgagcgcgta ggagttgatc
    15841 acccaggcga gcccggagga cgacatgccg agatcggtct ggatgctcgg cagtgcgatg
    15901 ttggtgatgg tgccgtccag cacgaccatc agctgcgccg ccgcgatcac caccagggcg
    15961 agacccgcat gcggtgacgc tggagtatct ccttccggct caggacgggc tttctgcaag
    16021 gtttctgaca agggggaact cctgctaatc ggaactctgt tcgatgtgac actacaaggg
    16081 gcctctgaca tttccggaac ggttttccgt ccgggagccg aacgcggaag gcggtgccgg
    16141 agaccgggtg gacgtaccgg ccgaggccgg tcggtcgggg agcgcctgct cggccgggag
    16201 gtccgcggga cccggacggc ccgcgcgggc gtcggcgggg gagaagacgg cgacgcgggg
    16261 acagccgggg accgtgacac ggagtggccg ggtgttttcc cggcccgggt gcggacagac
    16321 cttccaaggg ctcccgtgcg aaggggagcg gccggaggac cggcgcaggg cgaggcgaag
    16381 gagcgagaac agtgaccgca acgagccgta tcggagtgac ggggctggcg gtgatggggg
    16441 cgaacctcgc ccgcaacatc gcgcgtcgcg gggtgccggt ggccgtccac aaccgcacgg
    16501 cggagcggac gcgcaagttc atgaaggacc acggggacga gggcgccttc acggcggccg
    16561 agacggtgga ggacttcgtc ggggcgttgg agcggccgcg gcggatcatc atcatggtca
    16621 aggcgggcgg gccggtcgac acggtgatcg acgaactcgt gccgctgctg gaggaggggg
    16681 acatcctcat cgacggcggc aactcgcact tcaccgacac ccgccgccgc gtcgagcggt
    16741 gcgcgcggga cgggctgcgg ttcatcgggg cgggggtgtc cggcggcgag gagggcgcgc
    16801 tgctggggcc gagcatcatg cccggcggcg accgcgccgc ctacgccgag gtcgaggaga
    16861 tcctcaccgg catcgcggcg caggtcgacg ggacgccgtg ctgcacgtac gtggggccgg
    16921 acggcgccgg gcactacgtg aagatggtgc acaacggcat cgagtacgcc gacatccagc
    16981 tcatcgccga ggcctacgac ctgctgcgca acgtcgcggg cctggacgtg ccggtgatcg
    17041 cccggacctt cgaggagtgg aactccggcg acctggagtc gttcctcgtc gagatcaccg
    17101 cgaaggtgct ggccaagacc gacgagcgga ccggcgggcc gctcgtcgac gtcatcgtcg
    17161 acgaggccga gcagaagggc accggccgct ggaccgcgca ggacgccctg gagctcggcg
    17221 tcccgctgac cggcatcacc gaggcggtgt acgcgcgcac cctttcgtcg ctgcgcgagg
    17281 agcggggcag ggcgtcggcc gtgctgcggg ggcccgtgcc ggaggacggg tccgtccgcg
    17341 aggagctcgt cgacgacatc cggcaggcgc tgtacgcgag caaggtcgtc gcgtacgcgc
    17401 agggcttcgc ccagatgcac gcggcctccc gcgcctacgg ctgggacctc gacctgggcg
    17461 cgatggcgac gatctggcgc ggcggctgca tcatccgcgc ccgtttcctc gaccggatcc
    17521 gcgacgccta cgccgagcac cccgacctgg agaacctcct gaccgtcccg tacttcaccg
    17581 aggccgtcgc gaacgcgcag gacgcgtggc ggcgcgtggt gacgacggcg accgaacgcg
    17641 gcgtgccgat ccccgcgttc tcctcctcgc tgtcctacta cgacggctac cgccgcgaac
    17701 gcggcccggc ctccctcatc cagggcctgc gcgacttctt cggcgcgcac acctaccgcc
    17761 gcgtcgacgc cgagggcgcc ttccacaccc gctgggccca ggacggcacg gaggtccgca
    17821 ccgacacctg gccggtcggg gtccgtgcct tccggagggt tcgcgcggct tcagggccgc
    17881 cggagaacgg gaaggggcgc cgggaggatc ccggcgcccc tgcttctcgc gggcggcgtc
    17941 agtggcggcg gccgcggaaa cgctggagga gtccccgggc cttggcctgg tggcgagggt
    18001 cgcgggcgag ctgctcggcc ctcatccggg cctggcggcc ctgcgggctg ttcaggaatc
    18061 gtcggatacg ggtgatcacg gaagccatgc cgtccccttc ggtcactgcc ggatggaaac
    18121 cggccgtcca tcctgttcaa cggggattcc cccaagggcg ttcccgcacg cggcaacggg
    18181 ggtccgcccg cgccgcgtcg gggccgcgcc ggtcagacca gggaggccgg gcggatgttc
    18241 tggttgatgt ggaagacgtt gtcggggtca tagcgggctt tgatctcgga caggcggtcg
    18301 tagttgccgc ggtaggaggc gcggatgcgg tcctggcctt cgttgttcat gaggaagttg
    18361 acgtaggcgc cgcccgccga ggtcgcgtgg aggtcgctcc agtagtcgcg ggcccactgg
    18421 gtgatgcggg gcgcgttggc ggggtcgggg tcgatgccga cgatgacgcc cgcccagccg
    18481 ccgtcgcggt aggcgaaggg ggtggcgtcg gacgggacgc gggcgacggc gccgtcgatc
    18541 gggtagaggt gcatggtgga caggccggtg ggcaggagct cgccgtacct gcagtggacg
    18601 tcgatcgcgg cgtcggagat ctcctcgaag aagtccgcct tccagtacca ctggagcccg
    18661 gggggcagga gggcgtcgaa ggagctctgc agcacgtcga acggcatcgg gtgcaggccg
    18721 gtcagcagcg gcgagccgta ggacctgacg ggttcgagga cctcgtcggc ccggtcgtgc
    18781 gggccggtgt agcaccacat gaccatgcac accttgcggc cccacagctc ctcggggaag
    18841 ggcggggcgg gcgcgacggc ggccaggccg aaccagccgc tcagggtctc cggcagcgtg
    18901 gggatcaggt cgcggtacca gcgcatgacg tcggcggtgt cgacgaggtc gtacatgacg
    18961 gggccgccga tgatcgtgcc gtgctcgccg atgtcgtggc agcggaacgt gaacgaggtg
    19021 acgacgccga agttcccgcc gcctccccgc agcgcccaga agaggtcgtc gtgggagttg
    19081 tcgttcgccg tcacgaagga gccgtcggcg agcaccacgt cggcggagag caggttgtcg
    19141 acggtgaggc cgaacctgcg ggagaggtgg ccgatgccgc cgccgagcgt cagcccgccg
    19201 accccggtgg aggcgacgaa gcccgacggg gtggccatgc cgaactcgac cgtggcgtgg
    19261 tcgacgtcgc cccacacgca gccgccgtcc acccgcaccc ggtgctgctc ggggctgacg
    19321 gtggtgctgc gcatcgccga caggtcgacg gccagcgcgt cgtcccacac gcccaggccg
    19381 ccggcgttgt ggccgccgcc gcggacggag agctcgacgt cgtgttcgcg ggcgaaccgt
    19441 acgcacgcga tgacgtcggc gacgtcacgg caccgcgcga tcgcggcggg acgccggtcg
    19501 atcatcgcgt tgtagacggc gcgcgcctgg tcgtatcccg ggtcctccgg ccgtaccagc
    19561 tctccccgca gggtgccggc cagccgttcg tacgcggcgg tggtcatggt ctccccttcc
    19621 cgcagccatc ccttcgggaa tccccggcga ccggcctcct acgccctgca aatatgcaca
    19681 tataggtcta tttcagttaa atacgggcca tttcccctcc ggtggtgagg gattcgatct
    19741 ccaggaggtc ccggtacggt ccgggcacgg cggccagcgc cgtgtgcgtg ccgcgctgcg
    19801 ccacccgccc cccgtccatg acgacgatct cgtcggcgtg ccggagggcg gcgaggcggt
    19861 gggcgaccag gacgacggtg ccgcctccgg gggaggtgaa cagctcgcgg acgagttcgt
    19921 cggcggtggc ggcgtcgagg ccctcggtcg gctcgtcgag cagcaggacg cccgggtcgg
    19981 ccaggagcgc gcgggccagc agcagccgcc gccgctgccc gccggacagg gactgcgggg
    20041 tgacgggggt gtcacggccg agcggcagcg cctcgacgtc gtcgaggagc cgggcccggc
    20101 ggagcacgcc ggtcaggtcg gcgtcggtcg cgccggggcg ggccagcagc aggttcgccc
    20161 ggaccgtggt ggcgaagacg tgcgcgtcct gcgcgagccc gcacacggcg cggcggacgt
    20221 cgtcgggcgc gtacgacgcc agggggaggc ccgccagcag ggcggtgccc cggtccagcg
    20281 gcacggcacc ggacaacgcc gccagcaggg tgctcttgcc cgcgccgctc gcaccgacga
    20341 cggcgatccg gcggccgcgc tccacccgca ggtcgacctg ctccaacgcc gtacgggcgc
    20401 cgtagcggac ggaggcgccg agcagctcca cgcgcagcgg gccggggggc accggccggg
    20461 gatccgcggg gccgccggcc tccggagccc gcagcagggc cgcgatccgc cgcgccgcgg
    20521 gccaggccgt cacgccctgc cgcgcggcct cgcccagcgg caggaccagc tcgacggcga
    20581 ccagcgcggt gaggacgagc gtcgccgtcg tcaccgtccc ggcctcccgg acggccagga
    20641 gcacggccag cgcggtggcc gtctggacga cgagccccag ggccgccacc gtgtccgcga
    20701 ccagcgagtc ccggcgctcc agcaccgcga gccgcgcggc cgcccgcccg gcgtccgcgc
    20761 gcgcacccgc cgcggcgccg tggacggtca gctcgtccgc cccttcgacg aggtcgagcc
    20821 cggccgccgc gagcgcgtcc cgctgcgccg acaccgcctc gcccgtccgg cacgacgcca
    20881 gggccgccgc gagcgggagc aggacgcccg ccgccagcag cccggccgcc agcaccgcac
    20941 ccgaacgcgg atgcacgacg gtcacgaggg cgagcccggc tcccccgccg agcagcgccc
    21001 cggaggcggg cagcaggcag cgcagcagca ggtcctgaac gcagtcgacg tccgagagca
    21061 tcccgttcaa ggcggcggcg tccccgcccc gccaccgccc gcgccccagc gcggtgaaca
    21121 accggacccg cacccccgcc agcgactcca gcgccgcgtc gtgcccggcc agccgctcgg
    21181 cgtaccggaa cacccccttg aagaccgcgc agccccgcac cgccacgatc accaggccga
    21241 gcgccaccag cggcggccgc tccgccgccc gcgcgatcat ccacgccgac gccgcggcca
    21301 gccccagccc gcaccactgc gccagcgccc cggcccccac ggcccccgcc aaccgccacc
    21361 acgacacctc gcgcctcacg cgccctcctc cacgacccca tgagcggcca tcacagccgg
    21421 taccccgccc ggcctcccgc cccgcacgcc cccggcctcg ccgaacggag ctcccgggtc
    21481 cgcctgtgac ggcggtgttc cggtcggact tccggcccgt gtgtccgcag ccgcaccgaa
    21541 cggcgtttcc ggaaccttct gcgatgtcgg tctcccggct cgtacgcccg cagtcccgcc
    21601 gaacggcgtt tccgggtccg cctgcggccc tggggccttg gccggtctcc cggctcgtgc
    21661 acctgcagtc ccgccgaacg gtgtttccgg gtccgcctgt ggtgccgggg ttccggcggg
    21721 agcggggacc cggatgatgc ggtccgcgcg ggccaggagg gaggggcggt gggcgaccag
    21781 cagcaccgtg cggtcctcga acagggcgtc ggccgccagc agcgcggcct cggtggccgg
    21841 atcgaggtgg gcggtcggct cgtcgaggag caagaacggc gcgccgcgga gccgcgcccg
    21901 ggtcagcgcc agccgctgcc gctgcccggc cgacaacacc gtgccccgct cgtcgagcac
    21961 ggtgtcgtag ccgcggggga gcgcggtgat gaacgtgtcg gcgcccatgg cggcggccgc
    22021 cgagcgcagc gcctccccgg agacgtccgg cagtcccagc gcgaggttct cggcgaccga
    22081 ggcggcgaac agccgggggt gctgcgggac ccaggacagg gacgcgtgcc aggcggcgag
    22141 gtccagttcc cgcaggtcca cgccgtcggc gaggacacgt ccctcggtgg gctcgagcag
    22201 ccccaggacc aggcgcagga gcgtcgattt ccccgccccg ctcggcccgg ccagcgcgac
    22261 cttctccccg gggcggacct ccaggctcag ccccgtgaac accggccgcg acgcccccgg
    22321 gtacgcgaac ccgacgttct ccagcaccag gtgcggcgcc ctccccgtcg gacgccgccc
    22381 gccgttccgc cggacggccg gagcggcggc gggggcgtcc agcgcggtga aggcctgctc
    22441 cgcggcggcg atgccctcgc tgctggcgtg gaagcgcatg cccagagccc gcagcgggag
    22501 gaaggcctcg ggggtcagca gcagcacgag cagccccgtg gacagg
//
