LOCUS       NZ_CP026498            21089 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. CB01881 chromosome.
ACCESSION   NZ_CP026498
VERSION     NZ_CP026498.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB01881
  ORGANISM  Streptomyces sp. CB01881
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     A 3-hydroxy-3-methylglutaryl-CoA synthase gene based probe for the
            discovery of the acyltransferase-less polyketide synthases
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) Xiangya International Academy of
            Translational Medicine, Tongzipo, Changsha, Hunan 410000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002953255.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 02:39:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,978
            CDSs (total)                      :: 7,904
            Genes (coding)                    :: 7,565
            CDSs (with protein)               :: 7,565
            Genes (RNA)                       :: 74
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 124 of 339
            Pseudo Genes (incomplete)         :: 251 of 339
            Pseudo Genes (internal stop)      :: 10 of 339
            Pseudo Genes (multiple problems)  :: 45 of 339
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:44:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10387421
            Orig. end                         :: 10408510
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026498.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21089
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="41"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21089
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21089
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11089](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11089
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            <213..>344
                     /locus_tag="C2142_RS40860"
                     /old_locus_tag="C2142_34765"
                     /pseudo=""
     CDS             213..>344
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133208.1"
                     /locus_tag="C2142_RS40860"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="C2142_34765"
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRKRYIVTDTIGLLLVVLVTAASVQDGTAGWQLLTAVAADHPII"
     misc_feature    226..246
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(401..538)
                     /locus_tag="C2142_RS34690"
     CDS             complement(401..538)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS34690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_153882846.1"
                     /transl_table=11
                     /translation="MSMNDAYHRFVADQQADQEEADAKERIRQANRADMRAELAPLDVL
                     "
     misc_feature    587..601
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.01"
                     /tool="antismash"
     gene            complement(707..1846)
                     /locus_tag="C2142_RS34695"
                     /old_locus_tag="C2142_34770"
     CDS             complement(707..1846)
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (52-302). E-value: 5e-11. Score:
                     34.2. Matches aSDomain:
                     nrpspksdomains_C2142_RS34695_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444294.1"
                     /locus_tag="C2142_RS34695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34770"
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_148646830.1"
                     /sec_met_domain="ADH_N (E-value: 2e-26, bitscore: 90.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5e-18, bitscore:
                     64.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTTDTTDTTNTTNAGTSTTSATSTTDTAQPRSVSAYAAPAPKA
                     PLEKTTVLRRAVGEHDILIDVRFAGICHSDIHQVSEDWGDGIFPMVPGHEIAGVVAEVG
                     PGVTRWAVGDRVGVGCFVDSCRECDNCLAGLQQYCSGTPGAVFTYNGVGRDGEPTYGGY
                     SSQLVVDEGYALRIPDALPLDVAAPLLCAGITLYSPLTHWGAGPGKKVAIVGLGGLGHM
                     GVKIAHAKGAEVTVLSQSLRKREDGLRLGADDYRATSDPATFTELAGTFDLIVNTVSAD
                     LDLSAYLGLLRTGGTLVQVGAPEKPVSVNAHALLVGRKSLSGSMIGGLPETQEMLDFCA
                     AHGIGAEIELIDADQINEAYERVLSSDVRYRFVIDTSTI"
     aSDomain        complement(941..1690)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS34695_PKS_ER.1"
                     /evalue="5.00E-11"
                     /label="C2142_RS34695_PKS_ER.1"
                     /locus_tag="C2142_RS34695"
                     /protein_end="302"
                     /protein_start="52"
                     /score="34.2"
                     /tool="antismash"
                     /translation="LRRAVGEHDILIDVRFAGICHSDIHQVSEDWGDGIFPMVPGHEIA
                     GVVAEVGPGVTRWAVGDRVGVGCFVDSCRECDNCLAGLQQYCSGTPGAVFTYNGVGRDG
                     EPTYGGYSSQLVVDEGYALRIPDALPLDVAAPLLCAGITLYSPLTHWGAGPGKKVAIVG
                     LGGLGHMGVKIAHAKGAEVTVLSQSLRKREDGLRLGADDYRATSDPATFTELAGTFDLI
                     VNTVSADLDLSAYLGLLRTGGTLVQVGA"
     gene            1947..2963
                     /locus_tag="C2142_RS34700"
                     /old_locus_tag="C2142_34775"
     CDS             1947..2963
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006132158.1"
                     /locus_tag="C2142_RS34700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34775"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_148646831.1"
                     /transl_table=11
                     /translation="MDQRTELSEFLRSRRARLRPEDVGLPDHGTRRRVPGLRREELAQL
                     AGVSTAYYTRLEQGHGESVSVAVLDSIARALRLTQAEREHLQRITKPARRRTGRAASTR
                     PQQVRPALQQLLDAMEGVPAYVLGRRLDIIGWNRLGNALLGDYSAMPPEQRNMAWHVFL
                     DPAARELYDDWEGKATDVVGILRLDAGRDPDDPRLASLIGELSLKSADFRRLWAAHDIR
                     DKGHGTKELHHPVVGRLTLRYETLRPAGEPDLVLVTYHADPGSTSAESLRLLASWVATG
                     PSGDSEVDRQVGGEVDRQVGREGDRVVGRSGATSGDPSTGGPGAASTGRTSSPETSR"
     misc_feature    2982..3001
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.72"
                     /tool="antismash"
     misc_feature    2985..2999
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 26.5"
                     /tool="antismash"
     gene            3139..4092
                     /locus_tag="C2142_RS34705"
                     /old_locus_tag="C2142_34780"
     CDS             3139..4092
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012272.4"
                     /locus_tag="C2142_RS34705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34780"
                     /product="globin domain-containing protein"
                     /protein_id="WP_148646832.1"
                     /transl_table=11
                     /translation="MEIVSTATEYDQLIARHHAMLLRRQILAPSSQSSPSAGASQAGAP
                     RVGLPYGGAPHDGMPYDGAADQRLILDNLGPVAPFADLIDHLYDSMFRRRPFLRSLFPS
                     SMEFQQAHLERMFTHVIEHLHRTDELADTLARLGRDHRKLGVRPVHYEAFEEALCEALR
                     HRAGSRWTEDLEAAWVRMLRFAVGAMVAGAESALTEPPYWHAVVVGHERRRPDLAVLRV
                     RTGEPYPYRAGQHGTVEHPLLPHSWRQYPMSRVPRADNELEFHVHRTGPGGVGEALVEH
                     TAVGDRLRLGPPRGTPAPEGVGRELQPAAHAPAPWR"
     gene            complement(4230..4811)
                     /locus_tag="C2142_RS34710"
                     /old_locus_tag="C2142_34785"
     CDS             complement(4230..4811)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020549443.1"
                     /locus_tag="C2142_RS34710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34785"
                     /product="hypothetical protein"
                     /protein_id="WP_194235834.1"
                     /transl_table=11
                     /translation="MPLTFRQPTNHSRATAAPGWIARTAATIALLAAALTGTTAGAAVA
                     AAPATSVPAAAPAGIPAAAPAVGAAAAPAEAPAAAAASVGGWTCPGVAVPPGYVITMFD
                     ISGCNGHGAWLQQPVRDGIWTCGGSPIVSGYVLTNFDSKGCSGVGAWYHQLVRNGIWTC
                     PYSPIPAGYRSTTYDARGCSGLGAWLTVRA"
     gene            complement(5132..6553)
                     /locus_tag="C2142_RS34715"
                     /old_locus_tag="C2142_34790"
     CDS             complement(5132..6553)
                     /GO_function="GO:0008430 - selenium binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985164.1"
                     /locus_tag="C2142_RS34715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34790"
                     /product="selenium-binding protein SBP56-related protein"
                     /protein_id="WP_148646833.1"
                     /transl_table=11
                     /translation="MPHGHDPRAGHGDPSLYRTPAEAIAAPPERLAYVAGFDRSAQRPD
                     ALITVDTDPASPTYGRVLNFAELPGLGDELHHFGWNACSSALAHACHENPERRYLLLPG
                     LRSSRLHVMDTRPDPVRPRLVKTVSAEELAARAGYSRPHTLHCGPDGVFLSCLGSGDGG
                     DGPGGVALLDHTTFDVLRAWETERGPQHLAYDVWWHLGTNVGVTSEWGTPSMVEDGVVP
                     ELLLGRKYGHALHFWELDSGRHLQRIDLGDQYQMVLELRPAHDPQAEWGFVGVVTNVED
                     LSASVWLWYRDGPAFTARKVIEIPAEPAKPEDLPPALQPFGAVPPLVTDINLSVDDRWL
                     YISAWGTGELFQYDVSDPFHPRLAGSVRLGGVVARTPHPAEPGRPLSGAPQMVEISRDG
                     RRLYLTNSLYGSWDDQFYPDGIEPWIVKLDADTESGGLTVDPRFYPHGDEFRGLRVHQT
                     HLAGGDASSDSYCYR"
     gene            6825..7787
                     /locus_tag="C2142_RS34720"
                     /old_locus_tag="C2142_34795"
     CDS             6825..7787
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (41-159). E-value:
                     4.8e-12. Score: 37.9. Matches aSDomain:
                     nrpspksdomains_C2142_RS34720_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059116.1"
                     /locus_tag="C2142_RS34720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34795"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_148646834.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.5e-11, bitscore:
                     41.6, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.5e-08, bitscore: 33.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFREDILGAPYEAVELPLAPDEEGAVSATLVRRLVPGSDRAVLY
                     VHGYVDYFFQTHLADHYVERGYSFYALDLRKYGRSLRPHQSPNFIRDLAAYDEELDAAV
                     RIIREQDGHRQLLVNGHSTGGLVTALWAGRRAGRGVVDGLFLNSPFLSMPAAPAVRAIG
                     APALDALGRFATTRKLPSTLNPHYVHSLHRDHRGEWDFDLKLKPAEGFPLYAGWLAAIQ
                     RGQRQARRGLGIDVPVLLMASTASISTTKWRAALHHADAVLRADDIAAVGPRLGRQVTI
                     VRIKDGMHDLALSGPDARTEFFAELDRWLAAYLPAPVAP"
     aSDomain        6948..7301
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS34720_Abhydrolase_1.1"
                     /evalue="4.80E-12"
                     /label="C2142_RS34720_Abhydrolase_1.1"
                     /locus_tag="C2142_RS34720"
                     /protein_end="159"
                     /protein_start="41"
                     /score="37.9"
                     /tool="antismash"
                     /translation="AVLYVHGYVDYFFQTHLADHYVERGYSFYALDLRKYGRSLRPHQS
                     PNFIRDLAAYDEELDAAVRIIREQDGHRQLLVNGHSTGGLVTALWAGRRAGRGVVDGLF
                     LNSPFLSMPAAPAV"
     gene            7967..8761
                     /locus_tag="C2142_RS34725"
                     /old_locus_tag="C2142_34800"
     CDS             7967..8761
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019434667.1"
                     /locus_tag="C2142_RS34725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34800"
                     /product="fused MFS/spermidine synthase"
                     /protein_id="WP_148647207.1"
                     /transl_table=11
                     /translation="MPDIDHDGGWLLTLDDTPQSYVDLGDPTHLEFEYTRRIGHLVDTL
                     APAGRPLDALHLGGGALTVPRYLAATRPGSRQQVVEVDGPLLALVEEHLPWQGPGVDIT
                     AVVGDARAVLETVSAGSLDLVVADVFHGSRTPAHLTSVEFVRAAAAALRPGGCYAANLA
                     DGPPLAFARAQAATLRAVFPEVCLIAEAPVLRGRRYGNILLAGSAGPLPAADLARRLAA
                     DIFPARLTDGAGLAEFCGRTPAVTDAEATDSPPPPDGAFSVG"
     gene            8989..9834
                     /locus_tag="C2142_RS34730"
                     /old_locus_tag="C2142_34805"
     CDS             8989..9834
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009715671.1"
                     /locus_tag="C2142_RS34730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34805"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_148646835.1"
                     /transl_table=11
                     /translation="MSSGEQPELGTVPETALWTLWQRAVEARRPDAVLHDPKAVELVER
                     IDYPFADRFGTSGVQAQLQALRVGCFDREVADFLAREPRGTVVCLGDGLETQYWRIDNG
                     RARWLSVDLPEALALRRQLLPPGPRQRYLAADATDLTWADEVDRNHGVLVTAQGLLMYL
                     PPTHVRDLIAGCAERFPGASLVLDAVPRWFSRLTLTGRMRTHAYQAPPMPWAMDAAERH
                     KLRTASPAVTTIRDVRPTGGRGLVAGLLPLALTIPPLATHRPSVTVLDFADRADRPTQS
                     "
     gene            10001..11089
                     /locus_tag="C2142_RS34735"
                     /old_locus_tag="C2142_34810"
     CDS             10001..11089
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014050086.1"
                     /locus_tag="C2142_RS34735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34810"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_148646836.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5e-42, bitscore:
                     142.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTAVLAEQIRARLAGYERRFGTLSAQYFRDLAVTFDAPSSSRF
                     TPDCLALLRDLTLRGGKRMRVALLFEAARLVTAEPVEGLDDAALSIELLQTHGLIHDDI
                     IDDTPTRRGGPSTYYAYRGRFPGRPQAALGLALLAGDLALALSLRVLLDSHAPLPVRHA
                     MVEVQTRAASATFVGQITDLERDFAADPDEGMLHDVADYKTARYSVLAPLRLGLLAAGV
                     DPSLHDEELRRYARLVGICGQMRDDYLDLFGDAGTMGKPTGTDIREGRRNYVVSAVLAA
                     ATDSERELVESALGDGACTEETIAAIRDIAERRGVPERMRADMQRRAQAAATEAAGWRP
                     RWREEAVAFFEYLPRWSVERAR"
     misc_feature    complement(10020..10034)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.68"
                     /tool="antismash"
     gene            complement(11236..12381)
                     /locus_tag="C2142_RS34740"
                     /old_locus_tag="C2142_34815"
     CDS             complement(11236..12381)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432611.1"
                     /locus_tag="C2142_RS34740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34815"
                     /product="beta-propeller fold lactonase family protein"
                     /protein_id="WP_148646837.1"
                     /transl_table=11
                     /translation="MQKITRLAVAVATALAAAAAVAPSTAAAYGGEGRPRGGHHAVFVQ
                     TDNPAGNQVIAYRRADDGQLTPAGTYDTNGLGGVLAGSVADHLASQGSLTYDPRHALLY
                     AVNAGSDTVSVFSVDGDRLALRQVVGSGGRFPVSVAVHDDTVYVLNALDGGSIQGYTVR
                     DGRLHEEADWNRRLGLDPNATPQFTNTPGQVGFTGEGSQLVVTTKANGSSLQVFNLDRS
                     GAPAATPVTTSLPGTVPFAFVPNGRHGLFLAEAGTNAVATFTIHHDGTATQEAFAATGQ
                     AATCWIVGVRNLLYTSNAGSSTLTGLRTADRGRQLTVLGNTPTDPGTVDAAVSSNGRYL
                     YAQTGVNGILDEFAINDDGSLTPIGSQTVPGGAGGEGVVAF"
     misc_feature    12835..12850
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            complement(13085..13990)
                     /locus_tag="C2142_RS34745"
                     /old_locus_tag="C2142_34820"
     CDS             complement(13085..13990)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012703.4"
                     /locus_tag="C2142_RS34745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34820"
                     /product="arginase family protein"
                     /protein_id="WP_162002633.1"
                     /transl_table=11
                     /translation="MRRDLVLVGAPTSAGSYAPGQEAAPSVLRELGLIDRLRAAGRRVR
                     DAGDGPLHVWAPDPQHPRAQNLAAVVQAVRAVADHVAGALEEDADVLVIGGNCTVALGV
                     MAALTARDPDAGLLYIDRHFDLNTPASTHEGALDWMGLAHGLDLPGAAEPLAAAFAHRP
                     LLTPDRIHLLGIDPEAATPWEREQARGLGLRWGSHLDLATTPGTEVSRALGTLPSGPLA
                     VHLDVDVLDFTDAPLAESTDGRNSGPTLDALSEALDTACRDPRFRALSICELNPSRAAG
                     HPAVLHRFAASLQHVLRATP"
     gene            14202..14786
                     /locus_tag="C2142_RS34750"
                     /old_locus_tag="C2142_34825"
     CDS             14202..14786
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="C2142_RS34750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34825"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_162002634.1"
                     /transl_table=11
                     /translation="MPRPREFDPDAVLNQAMLRFWERGYRATSIEDLVKATGVKPGSIY
                     SAFPGGKHALFVKSLERYSKLVVPQKLGRLEAPGASVAEVRGYFDGLVRDLLSPEGRQG
                     CLLVNTAIENAAEDDAAAAVVRGHLARLERCMTHALENAARRDEVRDSLDPGGTAKLLV
                     ATCQGLMVVGKANPDEAVLRAIVDNAFTALS"
     gene            14871..16091
                     /locus_tag="C2142_RS34755"
                     /old_locus_tag="C2142_34830"
     CDS             14871..16091
                     /NRPS_PKS="Domain: PKS_ER (18-320). E-value: 3.3e-36.
                     Score: 116.9. Matches aSDomain:
                     nrpspksdomains_C2142_RS34755_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024989.4"
                     /locus_tag="C2142_RS34755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34830"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_148646840.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.4e-13, bitscore:
                     49.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIVISAHGGPEVLTVTELPDPVAATGEVLIRVKAFGLNHAEAY
                     MRSGAWGQVAAVPGIECAGLVEADPSGELPVGTKVVAILGGMGRTRNGSYAELVTVPAT
                     NVVAVNSRLPWADLAAVPEVYATAYSALHGNLALKAGETLLVRGATSSLGQAAVNLAVH
                     QGATVLATTRNPAHAPLLKELGASDVLIDDGRLAAEVERRGLSVDALLDIVGNTVLRDS
                     LSTVGPRGRVCQIGFLGGFSPVADFDPIADLPSGVQLSFFGSAFVLGTPAFPLSGVPLD
                     EIYVQVEAGGLRARPTRIFRFDEIVEAHRVMEAGQAQGKDGRRSRLTRPHHRVRKPAAP
                     PQGPAPHRRPHPPSTPPSAPRDRSGSLGELCGPGPCGGPGPLGCYAARAARPGARRRPE
                     EPWSSRP"
     misc_feature    14872..14886
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.4"
                     /tool="antismash"
     aSDomain        14925..15830
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS34755_PKS_ER.1"
                     /evalue="3.30E-36"
                     /label="C2142_RS34755_PKS_ER.1"
                     /locus_tag="C2142_RS34755"
                     /protein_end="320"
                     /protein_start="18"
                     /score="116.9"
                     /tool="antismash"
                     /translation="ELPDPVAATGEVLIRVKAFGLNHAEAYMRSGAWGQVAAVPGIECA
                     GLVEADPSGELPVGTKVVAILGGMGRTRNGSYAELVTVPATNVVAVNSRLPWADLAAVP
                     EVYATAYSALHGNLALKAGETLLVRGATSSLGQAAVNLAVHQGATVLATTRNPAHAPLL
                     KELGASDVLIDDGRLAAEVERRGLSVDALLDIVGNTVLRDSLSTVGPRGRVCQIGFLGG
                     FSPVADFDPIADLPSGVQLSFFGSAFVLGTPAFPLSGVPLDEIYVQVEAGGLRARPTRI
                     FRFDEIVEAHRVMEAGQAQGK"
     CDS_motif       15291..15353
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C2142_RS34755_0001"
                     /evalue="1.20E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="C2142_RS34755"
                     /protein_end="161"
                     /protein_start="140"
                     /score="17.8"
                     /tool="antismash"
                     /translation="GETLLVRGATSSLGQAAVNLA"
     gene            complement(16022..17557)
                     /locus_tag="C2142_RS34760"
                     /old_locus_tag="C2142_34835"
     CDS             complement(16022..17557)
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061101.1"
                     /locus_tag="C2142_RS34760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34835"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_148646841.1"
                     /transl_table=11
                     /translation="MERSSRSSYQNANSRSGAGSRSGGSSFYGSRPAGGRRSPNGGGRQ
                     GSPSLGEFAMPVSSTPALPAVESFDELDMPKALLTVLTRHGVTSPFPIQAATLPNSLAG
                     RDVLGRGRTGSGKTIAFGLAVLARTAGRKAEPRRPLALVLVPTRELAQQVTEALTPYAH
                     AVRLRMATVVGGVSIGRQAQALNRGAEVVVATPGRLKDLIQRGDCRLDEVDVTVLDEAD
                     QMADMGFLPQVTELLEQVADGGQTMLFSATLDRNVDRLVRRFLEDPVTHSVDPSAAAVS
                     TMEHHVLQVQNFDKDATIAHIASRDGGVIMFIDTKHGADRLVEDLLASGVKAAALHGGK
                     SQPQRTRTLEQFRTGQVTALIATNVAARGIHVDGLDLVVNLDPPGDHKDYLHRGGRTAR
                     AGGSGTVVTLVLPNQRRAMARMMTTAGITPVTTRVLAGDEELARITGARVPTGVPVVIP
                     DPVVERPRRGAATNRGRRSRPARISGDSRAAYGRDDQGSSGRRRAPGRAALAA"
     misc_feature    complement(17919..17935)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.49"
                     /tool="antismash"
     gene            complement(17930..18133)
                     /locus_tag="C2142_RS34765"
                     /old_locus_tag="C2142_34840"
     CDS             complement(17930..18133)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545914.1"
                     /locus_tag="C2142_RS34765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34840"
                     /product="cold-shock protein"
                     /protein_id="WP_148646842.1"
                     /transl_table=11
                     /translation="MATGTVKWFNAEKGFGFIEQEGGGPDVFAHYSNINAQGFRELLEG
                     QKVEFDVTQGQKGPQAENIRPL"
     misc_feature    18131..18146
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.26"
                     /tool="antismash"
     gene            18518..19375
                     /locus_tag="C2142_RS34770"
                     /old_locus_tag="C2142_34845"
     CDS             18518..19375
                     /EC_number="2.4.2.28"
                     /GO_function="GO:0017061 - S-methyl-5-thioadenosine
                     phosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133601.1"
                     /locus_tag="C2142_RS34770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34845"
                     /product="S-methyl-5'-thioadenosine phosphorylase"
                     /protein_id="WP_148646843.1"
                     /transl_table=11
                     /translation="MTADQDVLPSAEVAVIGGSGLYELLDDVTEVRVDTPYGEPSDALF
                     VGEVAGRRVAFLPRHGRGHRVPPHRIGYRANLWALHTLGVRQVVAPCAVGGLRPEYGPG
                     TLLVPDQFVDRTSGRVQTFYDGLPLPDGTVPEVVHVSMADPYCPAGRRAVMEAAREAAW
                     EPADGGTLVVIEGPRFSTRAESRWFTANGWSVVGMTGHPEAVLARELGLCYTSVALVTD
                     LDAGVESGEGVTHGEVLKEFARNVDRLRVVLFKALERLPLVRECTCPHALDGLTTGLPG
                     VAGA"
     gene            complement(19341..19811)
                     /locus_tag="C2142_RS34775"
                     /old_locus_tag="C2142_34855"
     CDS             complement(19341..19811)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020134965.1"
                     /locus_tag="C2142_RS34775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34855"
                     /product="hypothetical protein"
                     /protein_id="WP_194235835.1"
                     /transl_table=11
                     /translation="MITVVRGLLLAAGLALIGYGLYGLLGDPYITDPLGILVWAFGGLV
                     IHDGLWVPLVCLLGAFLVRGPVLRGWLVVAAAVTAVGLPAVLRADDDHGNPSVLPLPYL
                     RNWLLVLAATAGVALLVAFVGRWRHRDRDRDRDRDRDRDRAVRRRRPREDRS"
     gene            complement(19808..20923)
                     /locus_tag="C2142_RS34780"
                     /old_locus_tag="C2142_34860"
     CDS             complement(19808..20923)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020557318.1"
                     /locus_tag="C2142_RS34780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_34860"
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_241003327.1"
                     /transl_table=11
                     /translation="MRRGPLREGAFTSPLHEPRTVVVVGRWLGAALLVCFLTGLASHLL
                     QDPPGWLAPHLPARPVHGYRITQGLHVISGLAAIPLAGAKLWAVYPRLFEWPPARSVLH
                     ALERLGIALLVAAVLLELFTGLLNTLQWYPWPFPFRQTHFWLGWLATGGLLVHLCVKAP
                     LIASAWWRRTAPALAQRRAFLTATAAATGAVTLVTAGQTVPWLRSLDLLAPRRPDLGPQ
                     GLPVNRTAAQAGTVTVPADWRLRVDGPQPYELTLADLGELPQYEVELPISCVEGWSASA
                     RWTGVRVADLVRRAGAPPGSAVRVTSLEAEGPYRVTEMPAPYVDDPLSLLALRVNGDVL
                     AADHGFPARVIAPNRPGVLQTKWVAHIEVIA"
ORIGIN
        1 gccaactgga gtccgagaac aaggagttgc gggatgccct cacccacgcg ctcggggaac
       61 gacgcaccgc cgacctgcca ggccaccccc acgacacgcc gaagaagaaa tcttccgctg
      121 ccatcggacc ctgctgaccg agcgtcatga acaccgtcca ccacacatcg caccaggtca
      181 gcagcctgcg agtagggcaa gctcaagata acgtccggaa gcggtacatc gtcactgaca
      241 cgatcggctt gctgctggta gtgctggtca ccgccgcgag tgtgcaggac ggcaccgccg
      301 gctggcagct gttgaccgcg gtcgcagccg accacccgat cattggtggt cttcttgacc
      361 tcctagccgc gggctgccgg gctggcggtc cacagcttct tcataaaacg tcgagcgggg
      421 ccaactctgc gcgcatgtcg gcccggttgg cttgcctgat ccgctccttg gcgtctgcct
      481 cttcctggtc tgcctgctgg tccgcgacaa agcggtggta ggcgtcgttc atcgacatgg
      541 catgccgtcc ttgcgggttg ccgggtctgg ccttggttac cgggtctggc cttcagttcc
      601 aggatgcgcc ggtcggtggc acagggcacg gggccgacag gagaacacca cagggggcga
      661 gaacgggcag ccccttcctg catcaggaag gggctgctcc cgtggctcag atcgtcgagg
      721 tgtcgatgac gaagcggtag cggacgtcgc tggacagaac ccgctcgtag gcctcgttga
      781 tctggtcggc gtcgatcagc tcgatctcgg cgccgatgcc gtgggcggcg cagaagtcca
      841 gcatctcctg ggtctccggg agaccgccga tcatcgagcc ggacagcgac ttgcggccga
      901 ccagcagtgc gtgggcgttc acgctgacgg gcttctccgg cgccccgacc tggaccagtg
      961 tgccgccggt gcgcaggagg ccgaggtagg cgctcaggtc gaggtcggcc gagacggtgt
     1021 tgacgatcag gtcgaaggtg ccggccagct cggtgaaggt ggccgggtcg gaagtggcgc
     1081 ggtagtcgtc cgcgccgagc cgcaggccgt cctcccgctt gcgcagcgac tggctgagca
     1141 cggtgacctc ggcgcccttg gcgtgcgcga tcttcacacc catgtgcccg agtccgccga
     1201 ggcccacgat cgcgaccttc ttgcccgggc ccgcgcccca gtgggtgagc ggcgagtaca
     1261 gcgtgatgcc ggcgcagagc agcggcgcgg cgacgtccag cgggagcgcg tccgggatgc
     1321 gcagcgcgta cccctcgtcc accaccagct gcgaggagta gccaccgtac gtcggctcgc
     1381 cgtcgcggcc cacgccgttg taggtgaaga cggcgcccgg ggtgccggag cagtactgct
     1441 ggagcccggc caggcagttg tcgcactccc ggcaggagtc gacgaagcag ccgacaccga
     1501 cccggtcccc gaccgcccag cgggtcacgc ccgggccgac ctcggcgacc acgccggcga
     1561 tctcgtggcc cggcaccatc gggaagatgc cgtcgcccca gtcctcgctg acctggtgga
     1621 tgtcggagtg gcagatgccc gcgaagcgga cgtcgatcag gatgtcgtgc tcgcccacgg
     1681 cccggcgcag gacggtggtc ttctccagcg gcgccttcgg ggcgggggcg gcgtacgcgg
     1741 agacgctccg cggctgtgcg gtgtccgtgg tgctcgtggc gctcgtggtg ctcgttccgg
     1801 cgttcgtcgt gttcgtcgtg tccgtcgtgt ccgtcgtgtt cgtcatgtgc ttcagcctgc
     1861 gccgacccgg tccgggcaac cagatcagag cttgtcgtac gcacggccaa cgtacgactg
     1921 gcaggctcac cctcatactg ggccgcatgg accagcgcac cgaactcagc gaattcctcc
     1981 ggtcgcggcg ggcccggctg cgccccgagg acgtcggcct gcccgaccac ggcacccgcc
     2041 gccgcgtccc cggactgcgc cgggaggagc tggcgcagct ggcgggcgtg agcacggcct
     2101 actacacccg gctcgaacag ggccacgggg agtccgtctc cgtcgccgtg ctggactcga
     2161 tcgcccgcgc cctgcggctc acccaggccg agcgcgagca cctccagcgg atcaccaagc
     2221 ccgcccggcg caggacgggg cgcgccgcgt ccacccgccc gcagcaggtc cggccggcgc
     2281 tccagcagct gctcgacgcg atggagggcg tgcccgccta cgtgctcgga cggcggctgg
     2341 acatcatcgg ctggaaccgg ctcggcaacg ccctgctcgg cgactactcc gcgatgccgc
     2401 cggagcagcg caacatggcc tggcacgtct tcctcgaccc cgccgcgcgc gagctgtacg
     2461 acgactggga gggcaaggcc acggacgtgg tcgggatcct gcggctggac gccgggcgcg
     2521 accccgacga cccccggctg gcctcgctga tcggtgaact ctccctcaag agcgccgact
     2581 tccgccgcct ctgggccgcc cacgacattc gcgacaaggg ccacggcacc aaggaactgc
     2641 accacccggt ggtcggccgg ctcaccctgc gctacgagac gctgcgcccg gccggtgagc
     2701 ccgacctggt gctggtgacg taccacgccg atcccggctc cacctcggcc gagtcgctgc
     2761 ggctgctggc cagctgggtg gcgaccggcc cgtcgggcga cagcgaggtc gacaggcagg
     2821 tcgggggcga ggtcgacagg caggtcggga gggagggcga cagggtggtc gggaggtcgg
     2881 gcgctacgtc gggcgacccg tccacaggcg ggccgggcgc cgcgtcgacg ggccggacgt
     2941 cctctccgga gacgtcccgt tagtccggtg gtcccggtcc cgccgggacc accggccctg
     3001 tcccggccct tccgcccggc cgtgtaatgg acctgcggcg gtccgggccc acccctgccc
     3061 ggaatcggca gaagtccctt cggctgggtg aactcatgct gaacagaagc gatctgacgg
     3121 ctggttaggc tttcgatcat ggagatcgtc agcaccgcca ccgagtacga ccagttgatc
     3181 gcacgccacc acgccatgct cctgcgccgc cagatcctcg ccccgtcgtc gcagtcgtcg
     3241 ccgtcggccg gagcgtcgca ggccggagcg ccccgagtcg gtctgcccta tggcggcgcg
     3301 ccccacgacg gcatgcccta cgacggcgcc gccgaccagc ggctgatcct ggacaacctc
     3361 ggcccggtcg ccccgttcgc ggacctcatc gaccacctct acgactccat gttccggcgc
     3421 cggcccttcc tgcgcagcct cttcccctcc tcgatggagt tccaacaggc tcacctggag
     3481 cggatgttca cccatgtgat cgaacacctc caccggaccg acgagctcgc cgacacgctc
     3541 gcccggctcg gccgcgacca ccgcaaactg ggcgtccggc cggtccatta cgaggccttc
     3601 gaggaggcgc tctgtgaggc gctccggcac cgcgccggct cccggtggac ggaggatctg
     3661 gaggcggcct gggtgcggat gctgcgcttc gccgtcgggg cgatggtggc gggcgccgag
     3721 tccgcgctca ccgaaccccc ctactggcac gccgtggtgg tcggtcacga gcgacgccgc
     3781 cccgacctcg cggtgctgag ggtgcgcacc ggcgagccgt acccgtaccg ggccggccag
     3841 cacggcacgg tcgagcaccc gctgctgccg cactcctggc ggcagtaccc gatgagccgc
     3901 gtgccgcgcg cggacaacga gctggagttc cacgtccacc gcacgggccc gggcggagtc
     3961 ggcgaggccc tggtcgagca caccgccgtc ggcgacaggc tccgcctggg cccgccgcgc
     4021 ggcacgccgg cgcccgaggg cgtgggccgc gagcttcagc cggcggccca cgccccggcg
     4081 ccctggcgct gagggggcgg tcgggcggtc gggcggcagt ccggccggtc acgcccggac
     4141 tgccgcccgc acgccttcac cgcgcgccgg gggccgggtg ctgggaccgc tccgggcggg
     4201 gctcccgccg ggcgggccct acggcctggt caggcgcgta cggtgagcca ggcgccgagg
     4261 ccgctgcacc cgcgtgcgtc gtacgtggtg ctgcggtagc cggccgggat cggggagtac
     4321 gggcaggtcc agatcccgtt ccggacgagc tggtggtacc aggccccgac gccgctgcac
     4381 cccttggagt cgaagttggt caggacgtac ccggagacga tcggcgagcc cccgcaggtc
     4441 cagatcccgt cccgtaccgg ctgctggagc caggcgccgt ggccgttgca gccgctgatg
     4501 tcgaacatcg tgatgacgta gcccgggggg acggcgaccc cgggacacgt ccacccgccc
     4561 accgaggccg ccgctgcggc gggcgcttcg gcaggcgcag ccgctgcccc cacggccggg
     4621 gcggcagcgg gtatacccgc gggtgcggcg gcgggtacgg aggtggcggg agcagcggcg
     4681 acggccgctc cggccgtggt gcccgtgagc gcggccgcga gcagtgcaat ggtggcggcc
     4741 gtacgggcga tccaccccgg ggcggcggtc gcccgggagt ggtttgtcgg ctgacggaaa
     4801 gtcaaaggca tggcacaccg gtccgatcgg tagccctccc cgacgcgttc cggcgattgg
     4861 ggaggcgggt cagcagggac tcgtcgcacc ctagtgggcg cggcctgcgg cggtcgcggg
     4921 acggccgaaa ggcctgccaa catgaccgga aagccatccg acggcctacc tgtccgcccg
     4981 agtgcctgcc tgtccgcccg acgcctcacc cgcccgacgc ctcacccgcc cgacgcctca
     5041 cccgcccgcg gcgacaggcc cgggcccggg cccgcgacag gtccggaccc gggcctgtca
     5101 ccgtgggccg tccgcaggcc tgtccagcag gtcagcggta gcagtacgag tccgacgagg
     5161 cgtccccgcc cgccaagtgc gtctggtgca cccgcaggcc ccggaactcg tccccgtgcg
     5221 ggtagaagcg cgggtcgacg gtgagcccgc ccgactccgt gtcggcgtcc agcttgacga
     5281 tccacggctc gatgccgtcg gggtagaact ggtcgtccca ggacccgtac agcgagttcg
     5341 tcaggtagag ccgccgcccg tcccggctga tctcgaccat ctgcggtgcg ccgctcagcg
     5401 gtcggcccgg ttcggccggg tgcggcgtcc tcgccaccac cccgccgagc cgcaccgagc
     5461 cggccagccg agggtggaac gggtccgaca cgtcgtactg gaacagctcg ccggtgcccc
     5521 aggccgagat gtacagccag cggtcgtcca ccgacaggtt gatgtccgtg accagcggcg
     5581 gcaccgcgcc gaacggttgg agggccggcg gcaggtcctc cggcttcgcc ggctcggcgg
     5641 gtatctcgat caccttgcgc gcggtgaacg ccgggccgtc ccggtaccag agccacaccg
     5701 aggcggagag gtcctccacg ttggtgacca cgcccacgaa cccccactcg gcctgcgggt
     5761 cgtgcgccgg ccgcagctcc agcaccatct ggtactggtc gccgaggtcg atccgctgga
     5821 ggtgccgccc cgagtccagc tcccagaagt gcagtgcgtg cccgtacttg cggcccagca
     5881 gcagctccgg caccaccccg tcctcgacca tcgacggcgt gccccattcg ctggtcacac
     5941 ccacgttggt gcccaggtgc caccagacgt cgtaggcgag gtgctgcggc ccccgctccg
     6001 tctcccatgc gcgcagcacg tcgaaggtgg tgtggtcgag cagcgccacc ccgcccggcc
     6061 cgtcgccgcc gtccccgctg ccgaggcagg acaggaacac gccgtccggc ccgcagtgca
     6121 gcgtgtgcgg acgcgagtac cccgccctcg ccgccagctc ctcggcggac accgtcttca
     6181 ccagccgcgg ccgcaccggg tccggccggg tgtccatcac gtgcagccgg gaggaccgca
     6241 gccccggcag cagcaggtac cgccgctccg ggttctcgtg gcacgcgtgc gccagcgcgc
     6301 tggagcaggc gttccagccg aagtggtgca gctcgtcgcc cagccccggg agttcggcga
     6361 agttgagcac ccgcccgtag gtcggcgacg ccggatcggt gtccacggtg atcagcgcgt
     6421 ccggccgctg cgccgaccgg tcgaacccgg ccacgtacgc cagccgctcc ggcggtgcgg
     6481 cgatcgcctc ggcgggcgtg cggtagaggg acgggtcacc gtgaccggcc cgcggatcgt
     6541 gcccgtgcgg catgctgact cctcaactgg cttcatcggc agctttattg acagcttcat
     6601 tgacggcttc atgggccagg ggagtgactc tggcccgggt agcgttccac aggaccacgg
     6661 gcgcacagca ggcgcacggg gagcggggcg gcccgcggcg cggcagccgc cgcgccacga
     6721 ccgtgctgcc gcgctccccg ctaccggccg gtattgtcgg tcgtccggat cgatggttcc
     6781 tgccggggca ggcaggtcag agcagaggtt gggtgcgggc gggcatggaa ttccgagaag
     6841 acatcctggg ggccccgtac gaggcggtcg agctgccgct cgcccccgac gaggagggcg
     6901 ccgtcagtgc caccctcgtc cggcggctgg tcccgggcag cgaccgcgcc gtgctgtacg
     6961 tccacggcta cgtcgactac ttcttccaga cccacctcgc cgaccactac gtcgagcgcg
     7021 gctactcctt ctacgccctc gacctgcgca agtacggccg ctcgctgcgc ccgcaccagt
     7081 cgccgaactt catccgcgac ctcgccgcct acgacgagga gctggacgcg gccgtccgga
     7141 tcatccgcga gcaggacggc caccggcagc tgctggtcaa cggccactcc accggcggcc
     7201 tggtcaccgc gctgtgggcc ggccgccggg ccggacgggg cgtcgtggac ggcctcttcc
     7261 tcaacagccc gttcctctcc atgcccgcgg ccccggccgt ccgcgccatc ggcgcgcccg
     7321 cactggacgc cctcggccgc ttcgccacca cccgcaagct cccttccacg ctgaacccgc
     7381 actacgtgca cagcctgcac cgggaccacc gcggcgagtg ggacttcgac ctcaagctca
     7441 agcccgccga ggggttcccg ctgtacgcgg gctggctcgc ggccatccag cgcggccagc
     7501 gccaggcccg gcggggcctg ggcatcgacg tccccgtcct gctgatggcc tcgaccgcct
     7561 cgatctccac caccaagtgg cgggccgccc tgcaccacgc cgacgccgtg ctgcgcgccg
     7621 acgacatcgc cgccgtcgga ccgcgcctcg gccggcaggt caccatcgtc cggatcaagg
     7681 acggcatgca cgacctcgcc ctctccgggc cggacgcgcg caccgagttc ttcgccgagc
     7741 tcgaccgctg gctcgccgcc tacctgccgg cgccggtggc tccgtgaccg ccgccccgga
     7801 gcccgtaccg gacgccgccc cggagcccgt accggacgcc gccccggagt ctgcaacgga
     7861 cgccgtaccc gagcccgtac cggacccggc accgcacccg gacccggcac cgcacccgga
     7921 gcccgtgccg gtcgcgcgga agaccgacct cggcctggcc cgcctgatgc ccgacatcga
     7981 ccacgacggc ggctggctgc tcaccctgga cgacacgccc cagtcgtacg tggacctggg
     8041 cgaccccacc cacctggagt tcgagtacac ccggcggatc ggccacctcg tggacaccct
     8101 ggcccccgcc ggccggccgc tcgacgcgct ccacctcggt ggcggcgcac tcaccgtgcc
     8161 ccgctacctg gctgccaccc gccccggctc ccggcagcag gtcgtcgagg tcgacgggcc
     8221 gctgctcgcc ctggtggagg agcacctgcc gtggcagggg cccggcgtcg acatcaccgc
     8281 ggtggtcggc gacgcgcggg ccgtactgga gaccgtctcg gccgggtcgc tggacctcgt
     8341 cgtcgccgat gtcttccacg gttcgcgcac ccccgcgcac ctcacctcgg tggagttcgt
     8401 acgggcggcc gccgccgcgc tgcgccccgg gggctgctac gccgccaacc tcgcagacgg
     8461 cccgccactg gccttcgccc gggcccaggc ggcgaccctg cgcgccgtct tcccggaggt
     8521 ctgcctgatc gccgaggccc cggtgctgcg ggggcgccgg tacggcaaca tcctgctggc
     8581 cggttcggcg ggcccgcttc cggccgccga ccttgcgcgc cgcctggcgg ccgacatctt
     8641 cccggcccgg ctgacggacg gcgccggcct ggcggagttc tgcgggcgca cgcccgcggt
     8701 gacggacgcc gaggccacgg acagcccgcc gcccccggac ggcgcgttca gcgtcggctg
     8761 aggctccgcc cggcgcgccg gtgcgtcgcg cgccgggccg gcacgccccg gggtgtcaga
     8821 atcggcgggt ccatgccggg ggaccgggag agcaggcccg tggcggccag gcctgtggca
     8881 gcgggccagg gagagccagg tccggcgcaa caggccggga cagtcagacc cgtggcagca
     8941 ggcccggggg agtcaggtcc gggagagtca ggtccgaggg agcgtgtgat gagcagcggg
     9001 gagcagcccg agctggggac ggtgccggag acggcactgt ggacactgtg gcaacgggcg
     9061 gtggaggccc gccggccgga cgccgtgctg cacgatccca aggcggtgga gctggtcgag
     9121 cggatcgact acccgttcgc cgaccggttc ggcaccagcg gcgtccaggc ccagctgcag
     9181 gcgctgcggg tcgggtgctt cgaccgtgag gtggcggact tcctggcccg ggagccgcgc
     9241 ggcaccgtcg tctgcctggg cgacggtctg gagacccagt actggcgcat cgacaacggc
     9301 cgcgcccgct ggctctccgt cgacctcccc gaggcgctgg ccctacgccg gcaactcctg
     9361 ccccccggcc cccgccaacg ctatctcgcc gccgacgcca ccgacctcac ctgggccgac
     9421 gaggtcgacc gcaaccacgg cgtcctggtc accgcacaag gcctgctcat gtacctcccc
     9481 ccgacgcacg tacgcgacct catcgccggc tgcgccgaac gcttccccgg ggcgtccctg
     9541 gtcctggacg ccgtcccccg gtggttcagc cgcctcaccc tcaccggcag gatgcgcacc
     9601 cacgcctacc aggccccacc catgccctgg gcgatggacg cggccgagcg ccacaagctc
     9661 cgcaccgcca gtccggccgt caccaccatc cgcgacgtcc gccccacagg cggccgcggc
     9721 ctcgtcgccg gcctcctccc actcgctctg accatcccac ccctggccac ccaccgcccc
     9781 tcggtcaccg tcctcgactt cgccgaccgt gcggacaggc ccacacagtc gtaggccgaa
     9841 ggcagcgacc tcgccgccgt ccccgaggtg ctcaccccct accgccccgc ccggtcctcc
     9901 aagcgttcga ggcagcatgg tgcctgacca ccgccaggac ctgaggtact ccggcctgcg
     9961 cgggcggcgc gcattcacca cccgaacgga agacatcccc atgaccgaca ccgccgtcct
    10021 cgccgagcag atccgggccc gtctcgccgg gtacgagcgt cggttcggca cgctgtccgc
    10081 gcagtacttc cgggacctgg ccgtcacctt cgacgctccg tcgtccagtc ggttcacccc
    10141 ggactgcctc gctctgctac gggatctgac gctgcgcggc ggcaagcgaa tgcgggtggc
    10201 cctcctcttc gaggccgccc gtctcgtgac tgccgagccc gtggaggggc tggacgacgc
    10261 cgcgctgagc atcgaactgc tccagaccca cgggctgatc cacgacgaca tcatcgacga
    10321 cacccccacc cgccgaggag gcccctccac ctactacgcc taccgggggc ggttccccgg
    10381 ccggccgcag gctgcgctcg ggctcgccct cctcgccggc gacctcgcac tcgccctgtc
    10441 cctgcgggtc ctcctcgatt cccacgcccc gctcccggtc cgacatgcca tggtcgaggt
    10501 gcagacgcga gcggcatcgg ccacgttcgt cggccagatc accgacctgg agcgggactt
    10561 cgccgcggac ccggacgagg gcatgctgca cgacgtggcc gactacaaga ccgcccgcta
    10621 ctcggtcctc gccccgctcc ggctgggact gctcgccgca ggcgtcgatc cctccctcca
    10681 cgacgaggaa ctgcggcgct atgcaaggct ggtggggatc tgcgggcaga tgcgcgacga
    10741 ctacctggac ctcttcggtg acgcggggac catgggcaag cccaccggaa cggacatccg
    10801 ggaggggcgc cgcaactacg tggtaagcgc cgtcctggca gcggccaccg actccgagcg
    10861 ggagctggtg gagtccgccc tcggcgacgg agcctgcacc gaggagacca tcgccgccat
    10921 ccgcgacatc gccgaacgcc gtggcgtccc ggagagaatg cgggcggaca tgcagcgccg
    10981 tgcacaggcg gccgccacgg aggccgccgg atggcgtccc aggtggcggg aggaggccgt
    11041 cgcgttcttc gagtacctgc cgaggtggag cgtcgagcga gcccgctgag ctccgagacc
    11101 tgggacctgg gacctgggac cgccgccaca ccggcagcgg cccgggtgtc agtccgagac
    11161 cggactcggt gcagtcggcg cgggtcgcgc acgcccaggt gcgagggacc cgcgccgact
    11221 gccgtgggcg gtgcgtcaga aggcgacgac gccttctccg ccggcgccgc cggggacggt
    11281 ctgcgagccg atcggggtga gggagccgtc gtcgttgatc gcgaactcgt cgaggatgcc
    11341 gttgacgccg gtctgggcgt agaggtagcg cccgttcgag gagaccgcgg cgtccacggt
    11401 gccggggtcg gtgggtgtgt tgcccaggac ggtcagttgg cggccgcggt cggcggtgcg
    11461 caagccggtg agggtggaac tgccggcgtt cgaggtgtag agcaggttgc gcacaccgac
    11521 gatccagcag gtggccgcct ggccggtggc cgcgaaggcc tcctgcgtgg cggtgccgtc
    11581 gtggtggatc gtgaacgtgg ccacggcgtt ggtgccggcc tcggccagga acaggccgtg
    11641 ccggccgttg ggcacgaacg cgaagggcac ggtcccggga aggctcgtcg tgacgggggt
    11701 ggcggcgggg gcgccggagc ggtcgaggtt gaagacctgg aggctgctgc cgttcgcctt
    11761 ggtggtgacc acgagctggg agccctcgcc ggtgaagccc acttgccccg gggtgttggt
    11821 gaactggggc gtggcgttcg ggtcgagtcc gaggcgccgg ttccagtcgg cctcctcgtg
    11881 gaggcggccg tcgcggacgg tgtagccctg gatcgagccc ccgtccagag cgttgaggac
    11941 gtagacggtg tcgtcgtgca cggcgacgct caccgggaag cggccgccgg agccgaccac
    12001 ctgccgcagc gcgagccggt cgccgtccac ggagaagacg gagacggtgt cgctgccggc
    12061 gttcaccgcg tacagcaggg cgtggcgcgg gtcgtaggtc agcgagccct gggaggcgag
    12121 gtggtcggcg accgatccgg ccagcacgcc gccgaggccg ttcgtgtcgt aggtgccggc
    12181 cggggtgagt tgtccgtcgt ccgcccgccg gtaggcgatg acctggttgc ccgccgggtt
    12241 gtcggtctgg acgaacaccg cgtggtgccc gccgcgcggg cggccttcgc cgccgtacgc
    12301 agccgcggtg gacggggcga ccgctgctgc cgccgcgagc gcggtcgcga cggccacggc
    12361 gagccgggtg atcttctgca tgaggttctg cctcctggag gtccggaacc gatcccaccc
    12421 aggtcttggg caccatggcc gggagtcgga gcgacatggg ggagggctgt gacgggaagc
    12481 ccgatgacgg tgaacggcgt gagagggctc gccacattcc ctcttgacac ggtatgtgac
    12541 gttctgtcgg aatccgctga agacggcgat cccggccccg ccgggatgtg cacggggctg
    12601 gtcccgggcc gcacgggatc cgatccgtcg ccgcccgatc ggatgggata tcaggcaggt
    12661 gcgtgggctg tcggtcggga ccagcaccgg gtctgaccgg cagcgcgact cccgctgggg
    12721 gtaccgctct ggtggcgagg aatctgccgt cgcaacgccg ggagacggcg ggccggcgcg
    12781 agggccggca gcagcgaacc ggcgctcggg tcggggggtg gggcgctgac ccgagtcacg
    12841 ccgatgtcac cgccgaggcg ggcccatggg cgcccaacct cgccgagcgg gagcatctga
    12901 cgtgccacgt tgcccggctc gacgcgcgcc ggtgcccctg gtgggctgtg ggttgcccca
    12961 ggcgccgatg tcgagggcgc cgatgccgag ggcgccgata ccgagggcgc cggcctcggt
    13021 ggtcagccgg tttccggtgg ggcggcgagg gttcggagga ggtacccgat gtcccggtcg
    13081 cagttcacgg ggttgcgcgc aggacgtgtt gaaggcttgc ggcgaaccgg tggaggacgg
    13141 cggggtgtcc ggcggcgcgg gaagggttga gctcgcagat cgagagcgct cggaatcgcg
    13201 ggtcccggca ggcggtgtcc agcgcctcgg acagggcgtc gagcgtgggg ccgctgttgc
    13261 ggccgtccgt gctttcggcg agcggcgcgt cggtgaagtc caggacgtcg acgtcgaggt
    13321 gcacggccag ggggccggac gggagcgtac cgagggcccg tgacacctcg gttcccggcg
    13381 tggtggcgag atcgaggtgc gagccccatc gcaggcccag gcctcttgcc tgctcacgtt
    13441 cccagggggt ggcggcctcg gggtcgatgc cgaggaggtg gatccggtcc ggggtgagca
    13501 gcgggcggtg ggcgaaggcg gccgccagcg gctccgcggc tccgggcagg tccagtccgt
    13561 gggcgagccc catccagtcg agggcgccct cgtgggtgct cgcgggtgtg ttgaggtcga
    13621 agtgccggtc gatgtagagc aggccggcgt ccgggtcgcg tgccgtgagg gctgccatca
    13681 cgcccagtgc gacggtgcag ttgccgccga tgaccaggac gtccgcgtcc tcctccagcg
    13741 ccccggcgac gtggtcggcg accgccctga cggcttggac cactgccgcc aggttctggg
    13801 cccgcgggtg ctgcgggtca ggggcccaca cgtgcagcgg cccgtcccct gcatcccgta
    13861 cccggcggcc cgccgccctc aggcgatcga tcaggcccag ctcgcgcaac acgctcggtg
    13921 cggcctcctg gccgggcgcg tagctgcccg cactggtcgg cgcgcccacc aagacgagat
    13981 cccgtcgcat ccacccatca tcgccgtccg cccggacggg cgcgagcggg ctgctcccgc
    14041 gggtcaccag ggacgtccgg cgcatgacgg cggacaggcg gacaggcccg ttccggcagg
    14101 ggcggcgctg ctcgcggccc ggcccggccg gtcttccggg accggtggcc ggcaggcggc
    14161 ggcccgttgt tcttgaatgg tcgctcatgt atgtttctcc catgcccaga ccgcgcgagt
    14221 tcgaccccga cgccgtgctg aaccaggcga tgctccggtt ctgggagcgc gggtaccggg
    14281 ccacgtcgat cgaggacctg gtgaaggcca cgggcgtcaa gcccggcagc atctacagcg
    14341 cgtttcccgg tggcaagcac gcgctcttcg tgaagtcgct ggagcgctac tcgaagctgg
    14401 tcgtgcccca gaagctcggc cggttggagg cgccgggcgc gtcggtggcg gaggttcgcg
    14461 gctacttcga cggactggtg cgagacctgc tcagccccga agggcgccag ggttgccttc
    14521 tggtcaatac ggcgatcgag aacgccgccg aggacgacgc ggcggcggcc gtcgtgcgcg
    14581 gccacctggc gcgcctggag cggtgcatga cccacgccct ggagaatgcc gcccgccggg
    14641 acgaggtgcg ggactcgctg gacccgggcg gcactgccaa gctgctggtc gcgacctgtc
    14701 agggactcat ggtcgtcggc aaggcgaatc ccgacgaggc ggttctgcgg gccatcgtcg
    14761 acaacgcctt caccgcgctg tcctgacggc gcagcaattc gggccaccgt gcgcggtggc
    14821 cctttcgtcg gcccgatagt tgaatgacta ctcaagaacg aggttcggac atgaaggcca
    14881 ttgtcatatc cgcccacggc ggccccgagg tcctcacggt cacggagctg cccgacccgg
    14941 tggccgccac cggcgaggtc ctcatcaggg tcaaggcgtt cggcctcaat cacgcggagg
    15001 cgtacatgcg aagcggcgcc tggggtcagg tggccgccgt ccccgggatc gagtgcgccg
    15061 gtctcgtcga ggccgacccc tcgggtgaac tccccgtcgg gacgaaggtg gtggcgatcc
    15121 tcggcggcat gggacggacc cgcaacggca gctacgcgga actcgtgacc gtccccgcga
    15181 ccaacgtggt ggccgtgaac tcgcgtctgc cgtgggccga cctggccgca gtgcccgagg
    15241 tgtacgccac ggcgtacagc gccctgcacg gcaacctcgc cctcaaagcc ggggagacac
    15301 tgctggtccg gggcgcgacc tcatccctcg ggcaggccgc cgtcaacctc gccgtccacc
    15361 agggcgcaac ggtgctcgcc accacccgca atccggcaca cgcgccgctg ctcaaggaac
    15421 tcggagcctc cgacgtgctg atcgacgacg ggcggctggc cgcggaggtc gaacgcaggg
    15481 gcctctccgt cgacgcgctg ctcgacatcg tcggcaacac ggtgcttcgc gactctctga
    15541 gcacggtcgg gccgcgcggc cgggtctgcc agatcggctt cctcggtgga ttctcaccgg
    15601 tggctgactt cgacccgatc gccgatctgc ccagcggcgt ccaactcagc ttcttcggca
    15661 gcgccttcgt cctgggaacc cccgccttcc ccctctcggg cgttccgctg gacgagatct
    15721 acgtccaggt cgaggccggc ggccttcgag cccgccccac ccggatcttc cgcttcgacg
    15781 agatcgtcga agcccaccgg gtgatggagg ccggccaggc ccagggtaaa gatggccgtc
    15841 gttctcgact gacccgtccg catcaccgag tccgcaagcc ggcggcacct ccacagggcc
    15901 cggcgccgca tcgccgcccc cacccgccct caacgccacc gtcggcacct cgggaccggt
    15961 cagggtccct gggcgaactg tgcgggcccg gtccgtgcgg tggcccgggc ccgctggggt
    16021 gctacgcggc gagggcggcg cgcccgggcg cccggcggcg gccggaggag ccctggtcgt
    16081 cgcggccgta ggccgcccgg gagtcgccgc tgatccgggc ggggcggctg cggcggccac
    16141 ggttcgtggc agcgccgcgg cgcggtcgtt cgacgacggg gtcggggatg acgacgggca
    16201 cgccggtggg cacgcgggcg ccggtgatgc gggcgagctc ctcgtcgccg gcgaggaccc
    16261 tggtggtgac gggggtgatg ccggccgtgg tcatcatgcg ggccatcgcg cggcgctggt
    16321 tgggcaggac gagcgtgacg acggtgccgg acccgccggc ccgggccgtg cgcccgcccc
    16381 ggtgcaggta gtccttgtgg tcgcccggcg ggtccaggtt gacgaccagg tcgagcccgt
    16441 cgacgtggat gccccgggcg gcgacgttgg tcgcgatcag tgcggtcacc tggccggtgc
    16501 ggaactgttc cagggtgcgg gtgcgctgcg gctgggactt gcccccgtgg agggccgcgg
    16561 ccttcacccc gctcgcgagc aggtcctcga ccaggcggtc cgcgccgtgc ttggtgtcga
    16621 tgaacatgat cactccgccg tcacgggagg cgatgtgcgc gatcgtggcg tccttgtcga
    16681 agttctgcac ctgcagcacg tggtgctcca tggtgctgac cgccgccgcg gacgggtcca
    16741 ccgagtgcgt gaccgggtcc tccaggaagc gccgcacgag gcggtcgacg ttgcggtcca
    16801 gggtggcgga gaacagcatc gtctggccgc cgtcggcgac ctgttcgagg agctcggtga
    16861 cctgcggcag gaagcccatg tcggccatct ggtcggcctc gtcgaggacg gtgacgtcga
    16921 cctcgtccag ccggcagtcg ccgcgctgga tcaggtcctt gagccggccg ggggtggcca
    16981 ccacgacctc cgccccgcgg ttgagcgcct gtgcctggcg gccgatcgac accccgccga
    17041 ccacggtcgc catccgcaga cgcaccgcgt gggcgtaggg ggtgagggct tcggtgacct
    17101 gctgtgccag ctcgcgggtg gggaccagga ccagggccag cgggcggcgg ggctcggcct
    17161 tccgcccggc ggtgcgggcc agcacggcga ggccgaacgc gatggtcttg ccggaaccgg
    17221 tgcggcctcg tccgaggacg tcgcggccgg ccagcgagtt cgggagcgtc gcggcctgga
    17281 tcgggaacgg cgaggtgacg ccgtgccggg tcagcaccgt cagcagcgcc ttcggcatgt
    17341 ccagctcgtc gaaggactcg acggccggca gcgccggggt gctgctcacc ggcatcgcga
    17401 actcccccag cgagggggaa ccctggcggc cacccccgtt gggggagcgc cggccaccgg
    17461 ccggccggga gccgtagaag gagctgccgc cggagcggga gcctgcgccg gaccgggagt
    17521 tggcgttctg gtaggaggag cgactggagc gttccatggg aaaaccttcc tcagggcggc
    17581 acgtcacgag gaaggctccg tggcgcggtg cgccggcgga gaccgcaagg gaacgggccg
    17641 gagtgtgacg ggcggagcgt ggacggtaga accgtgcggc acgtcgtcac ctacggtcgg
    17701 cgctcaccga aaggagcggg agcgaagaac tcgaaccgtg aactgtcacg gcagggcgca
    17761 gatccggacg cggcgctgtg cgtctcgcgt gggggatggc caccggtggc ggagccaggg
    17821 ggcctcaacg gccggggacg cgtcgtggtg caacgccgag gggcccgcac cgggcatcat
    17881 gtacgcggtg cgggcccctc actgctgggc gtatgccgtg gcaggagaac tacagcgggc
    17941 ggatgttctc ggcctgcggg cccttctggc cctgcgtgac gtcgaactcg accttctggc
    18001 cctcgagcag ctcacggaag ccctgggcgt tgatgttcga gtagtgggcg aacacgtccg
    18061 ggccgccacc ctcctgctcg atgaagccga agcccttttc cgcgttgaac cacttcacgg
    18121 tgccggtagc cataaaaaac aatctccttc aaatgctgtc cgaagcacgc acagtgcggg
    18181 cttccagtcg ccgcgatgag cgcccgcccg gggaagagcc gggaaacaaa aatgcgcctg
    18241 cgaatacatc agcaggcgca cacaaagttc atgggaacca ctactgcaac tagaacgact
    18301 ctagcaggcc cgggaccgaa acggtggata ttccggcgcc ggtttcagga aaacctcccc
    18361 ccggggccgt cggccgggtg gtggcggtcc tcggcaccgg cgccacgcgt gcggtgcgag
    18421 ggacgttcgt gattcgtaag gcccggtgcc ctggttccgg cagggaccgt tcctacagtt
    18481 gccgggaggt tgttcccgag aagaagggtg gaccgcgatg acggccgacc aggacgtcct
    18541 gccgagcgcc gaggtggccg tgatcggcgg ctccggactc tacgagctgc tggacgatgt
    18601 gacggaggtg cgggtggaca ccccgtacgg cgaaccgagc gacgcgctgt tcgtgggtga
    18661 ggtggccggt cgccgggtcg ccttcctgcc ccggcacgga cgcggccacc gggtgccccc
    18721 gcaccggatc ggctaccgcg ccaacctgtg ggcgctgcac accctgggcg tgcggcaggt
    18781 ggtggcgccg tgcgcggtcg gcgggctgcg cccggagtac gggccgggca ccctgctcgt
    18841 ccccgaccag ttcgtggacc ggacctcggg gcgggtgcag accttctacg acgggctgcc
    18901 gcttccggac ggcacggttc cggaggtcgt gcacgtgtcg atggccgacc cgtactgccc
    18961 ggcggggcgg cgcgcggtga tggaggccgc ccgggaggcg gcctgggagc cggccgacgg
    19021 cggcacgctc gtggtgatcg agggcccgcg cttctccacc cgcgccgagt cccgctggtt
    19081 caccgccaac ggctggtcgg tggtcggcat gaccggccac cctgaggccg tcctcgcccg
    19141 tgaactcggg ctctgctaca cctcggtggc cctggtgacc gatctcgacg ccggggtgga
    19201 gagcggcgag ggcgtcaccc acggcgaggt cctcaaggag ttcgcccgca acgtcgaccg
    19261 gttgcgcgtc gtgctgttca aggcactgga gcggctgccg ctcgtgcgcg agtgcacctg
    19321 cccgcacgcc ctggacggtc tcacgaccgg tcttcccggg gtcgccggcg cctgacggcc
    19381 cggtcccggt cccggtcccg gtcccggtcc cggtcccgat cccggtgccg ccaccgcccg
    19441 acgaacgcga ccagcagcgc gacgccggcg gtggcggcca gtaccagcag ccagttgcgc
    19501 aggtagggca gcggcagcac cgacgggttg ccgtggtcgt cgtcggcgcg cagcacggcg
    19561 ggcaggccga cggcggtgac ggccgccgcg acgaccagcc agccgcgcag cacgggcccg
    19621 cgcaccagga acgcgcccag caggcacacc agcggcaccc acagcccgtc gtggatcacc
    19681 agcccgccga acgcccagac caggatgccc agcgggtcgg tgatgtacgg gtcgccgagc
    19741 agcccgtaga ggccgtagcc gatcagggcg agcccggccg cgagcagcag accgcggacc
    19801 acggtgatca tgcgatcacc tcgatgtgcg cgacccactt ggtctgcagg acaccggggc
    19861 ggttcggcgc gatgacgcgc gcggggaatc cgtggtccgc ggccaggacg tcgccgttga
    19921 cccgcagggc gagcaggctg agcggatcgt cgacgtacgg cgccggcatc tccgtcaccc
    19981 ggtacggtcc ctcggcctcc agcgaggtga cccgcaccgc cgagccgggc ggggctcccg
    20041 cccgccgcac caggtcggcc acccggaccc cggtccaccg ggccgaggcg ctccagccct
    20101 ccacgcagga gatgggcaac tccacctcgt actggggcag ttcacccagg tcggcgaggg
    20161 tgagttcgta cggctgcggg ccgtccaccc ggagccgcca gtcggcgggc acggtgaccg
    20221 tcccggcctg ggcggcggtg cggttcaccg gcagcccctg ggggccgaga tcggggcggc
    20281 gcggggccag caggtccagg gaacgcagcc acggcacggt ctgtccggcg gtgacgaggg
    20341 tgacggcgcc ggtggcggcg gcggtcgccg tgaggaacgc ccggcgctgc gccagggccg
    20401 gagcggtccg gcgccaccag gcggaggcga tgaggggtgc cttgacgcag aggtggacca
    20461 gcagtcctcc ggtcgccagc cagcccagcc agaagtgggt ctgccggaag gggaacggcc
    20521 acgggtacca ctgcagggtg ttcagcaggc cggtgaacag ctccagcagg acggccgcca
    20581 cgaggagtgc gatgccgagc cgctccaggg cgtgcagcac gctgcgcgcc ggcggccact
    20641 cgaacagccg tgggtagacc gcccacagtt tcgctccggc cagcgggatc gcggccaggc
    20701 cgctgatcac gtgcaggccc tgggtgatcc ggtagccgtg caccggccgt gcgggcaggt
    20761 gcggcgcgag ccatccgggc gggtcctgga gcagatggct ggccagaccg gtcaggaagc
    20821 agaccaggag ggccgcgccc agccagcggc cgacgacgac cacggtccgc ggctcgtgca
    20881 gcggtgaggt gaacgccccc tcgcgcaacg gcccgcgccg caggaacgcc gggggagcgg
    20941 gcagcggcgg gtcgtagcgg cggcgggcgg aaggagtgcc ggagtcggcg ggttcggtgt
    21001 ccacgcgtcc atcgaagcgc cccggcacgt cccgccggtg ctccgacgtg cttacggaat
    21061 gcgaacgccg gcctcgccga gcggtccgc
//
