LOCUS       NZ_CP026498            21047 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. CB01881 chromosome.
ACCESSION   NZ_CP026498
VERSION     NZ_CP026498.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB01881
  ORGANISM  Streptomyces sp. CB01881
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     A 3-hydroxy-3-methylglutaryl-CoA synthase gene based probe for the
            discovery of the acyltransferase-less polyketide synthases
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) Xiangya International Academy of
            Translational Medicine, Tongzipo, Changsha, Hunan 410000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002953255.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 02:39:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,978
            CDSs (total)                      :: 7,904
            Genes (coding)                    :: 7,565
            CDSs (with protein)               :: 7,565
            Genes (RNA)                       :: 74
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 124 of 339
            Pseudo Genes (incomplete)         :: 251 of 339
            Pseudo Genes (internal stop)      :: 10 of 339
            Pseudo Genes (multiple problems)  :: 45 of 339
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:44:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10062681
            Orig. end                         :: 10083728
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026498.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21047
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="atropopeptide"
                     /region_number="39"
                     /rules="atropopeptide_p450"
                     /tool="antismash"
     cand_cluster    1..21047
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21047
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11047](+)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11047
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     misc_feature    complement(314..326)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            complement(388..1128)
                     /locus_tag="C2142_RS33300"
                     /old_locus_tag="C2142_33375"
     CDS             complement(388..1128)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056997.1"
                     /locus_tag="C2142_RS33300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33375"
                     /product="Mut7-C RNAse domain-containing protein"
                     /protein_id="WP_148646517.1"
                     /transl_table=11
                     /translation="MERPEIWLSFAPELHLFVASARRGAPTALRTDGASTLGHVVESLG
                     VPLTEVGALVADGRPVGVGYAPAGGERISVEAVPRPQPAAAPVRFLLDVHLGTLTRRLR
                     LLGIDAAYENPDIGDAALAARSAAEQRVMLSRDRGLLRRRELWAGAYVYSHRPAEQLRD
                     VLSRFAPPLAPWSRCTTCNGVLRSVTKSTVQDQLRDGTERSYDAFAQCTECGQAYWRGA
                     HHASLDAIVADAVREFGTSALSEA"
     gene            complement(1269..1787)
                     /locus_tag="C2142_RS33305"
                     /old_locus_tag="C2142_33380"
     CDS             complement(1269..1787)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571710.1"
                     /locus_tag="C2142_RS33305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33380"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_148646518.1"
                     /transl_table=11
                     /translation="MSAEPTRRIVVVRHAKAEWSDVDDHERPLADQGRKDAPVAGRWLA
                     GAGIEPDLALVSTAVRTRETWKLMVPELPQRPRSVFEDRLYEASLGEIIALLNEVSDEV
                     ADVVLVGHNPGAHALADALAGEADGDLLARMNRSGFPTSAVAVLTFTGSWKSVEHGAGR
                     LVAFWAPHA"
     gene            complement(1906..4152)
                     /locus_tag="C2142_RS33310"
                     /old_locus_tag="C2142_33385"
     CDS             complement(1906..4152)
                     /EC_number="7.2.2.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0019829 - ATPase-coupled monoatomic cation
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136721.1"
                     /locus_tag="C2142_RS33310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33385"
                     /product="heavy metal translocating P-type ATPase"
                     /protein_id="WP_148646519.1"
                     /transl_table=11
                     /translation="MTTQALASTEVELQIGGMTCASCAARIEKKLNRMDGVEATVNYAT
                     EKAKVVVVDGVEVADLIATVEATGYTAVLPRPAATEPAGAAAGAAEADELAPLRQRLIT
                     ALALAVPVIAMAMVPALQFDNWQWLSLTLAAPVVTYAAWPFHRAAWTNARHGAATMDTL
                     VSLGTGAAFLWSLWALFLGNAGMPGMRHGFEFTIARSDGSSNIYLEAAAGVTAFILAGR
                     YFEARSKRTAGAALKALLELGAKDVTVLRGGAEVRIPTAELAVGELFVVRPGEKIATDG
                     VIEQGASAVDASMLTGESVPVEVAVGDSVTGATVNAGGRLVVRATRVGADTQLARMAKL
                     VEDAQNGKAAAQRLADRISAVFVPIVITLALATLGYWLGTGEGWAAAFTAAVAVLIIAC
                     PCALGLATPTALLVGTGRGAQLGILIKGPEVLESTRRVDTIVLDKTGTVTTGQMTLLAV
                     HAAEGVTEAEALRLAGALEHASEHPIARAVATAARKAGELPAVEGFENVPGLGVQGVVD
                     GHAVLVGREQLLADWSQYLSAPLAEAKRRAEAAGRTAIAVGWDGEARAVLEVADAVKPT
                     SAEAIARLRGLGLTPMLLTGDNAAVAATVAAEVGIRPEDVIAEVLPQDKVATVQRLQAE
                     GRVVAMVGDGVNDAAALAQADLGLAMGTGTDAAIEAGDLTLVRGDLLAAADAIRLSRRT
                     LATIKGNLFWAFGYNVAALPLAAAGLLNPMIAGAAMAFSSVFVVGNSLRLRTFR"
     misc_feature    complement(4234..4250)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 25.08"
                     /tool="antismash"
     misc_feature    complement(4235..4250)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 28.92"
                     /tool="antismash"
     gene            complement(4284..4559)
                     /locus_tag="C2142_RS33315"
                     /old_locus_tag="C2142_33390"
     CDS             complement(4284..4559)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136720.1"
                     /locus_tag="C2142_RS33315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33390"
                     /product="cation transporter"
                     /protein_id="WP_148646520.1"
                     /transl_table=11
                     /translation="MSCCSENGTCSTTATVEAPAAAVTTVYAVAGMTCGHCEQAVGKAV
                     SALAGVTAVSVDVQAGLVTVSAEAEPDEAALRAAIDDAGYELTGRA"
     misc_feature    4594..4609
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 24.76"
                     /tool="antismash"
     misc_feature    complement(4594..4610)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 25.73"
                     /tool="antismash"
     misc_feature    complement(4595..4610)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.42"
                     /tool="antismash"
     misc_feature    4632..4647
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 32.38"
                     /tool="antismash"
     misc_feature    4632..4648
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: medium, score: 28.54"
                     /tool="antismash"
     misc_feature    complement(4633..4648)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.11"
                     /tool="antismash"
     misc_feature    complement(4692..4707)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: medium, score: 25.7"
                     /tool="antismash"
     misc_feature    4738..4753
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 24.53"
                     /tool="antismash"
     misc_feature    complement(4738..4754)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: strong, score: 31.35"
                     /tool="antismash"
     misc_feature    complement(4739..4754)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 31.91"
                     /tool="antismash"
     gene            4802..5083
                     /locus_tag="C2142_RS33320"
                     /old_locus_tag="C2142_33395"
     CDS             4802..5083
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006348313.1"
                     /locus_tag="C2142_RS33320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33395"
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="WP_148646521.1"
                     /transl_table=11
                     /translation="MAGYHDDKDQVMRRLRRIEGQVRGLQRMVDADDYCIDVLTQVSAT
                     TKALQSVALQLLDSHLGHCVQDAIARGGGEADAKVAEASNAIARLMRA"
     gene            5189..6163
                     /locus_tag="C2142_RS33325"
                     /old_locus_tag="C2142_33400"
     CDS             5189..6163
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136719.1"
                     /locus_tag="C2142_RS33325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33400"
                     /product="hypothetical protein"
                     /protein_id="WP_148646522.1"
                     /transl_table=11
                     /translation="MNTALKIAAFATGLTTAFGAAYGVGHATGTGPAPRPAAAAHTGHT
                     GHAAEAPAGAEAAGDHLPGGLQVSERGYTLSLDSPFVTAGAPTDLRFRILGADGRPVTD
                     YRPEHEKELHLIVAPRDLATFQHLHPTRAADGTWSAATALPAAGEYRVFADFTPAGAAE
                     GLTLGTDLHAAGDLRPAPLPETGRSVAVDGYTVTLGGDLTPGRPARLTLTVTKDGRPVT
                     DLQPYLGAYGHLVALRAGDLAYLHVHPESTTPGPEVAFTATAPSPGAYRLFLDFKHGDT
                     VRTAAFTVATGDGAAPATAAPSTAAAPSTTAAPSTAPEGAHQH"
     gene            complement(6282..7274)
                     /locus_tag="C2142_RS33330"
                     /old_locus_tag="C2142_33405"
     CDS             complement(6282..7274)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006377975.1"
                     /locus_tag="C2142_RS33330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33405"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_148646523.1"
                     /sec_met_domain="APH (E-value: 8.1e-27, bitscore: 93.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSELVAHDDAQRNRDRDRDRTWAWVEGRLADGSRVTGGSRLRGGF
                     TSEMRRLRVEGPEGAEELVLRSFVAPFYLRHAEGLLTREADILTLLGADGGGVPVATLR
                     GVDATGEFCAYPSLLMTLLPGTVRVDEEELDQRCRLLAGQLARIHRVDVPEHARPRDYQ
                     AWVTPEGVRRPAGSARPEVWERAVEVIRRPPPSFPGRFLHRDYHPGNVLFSGGGSTGEL
                     RITGVVDWVETSWGPADLDVAHCSTALALLYGVPAGMAFAGRYLEAGGDLAVEPADHLY
                     WRLLDALAFAPDAEKVGVSWRELGRTDLTPALLAGRLEEYVEELLKRFG"
     gene            complement(7301..8167)
                     /locus_tag="C2142_RS33335"
                     /old_locus_tag="C2142_33410"
     CDS             complement(7301..8167)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009065617.1"
                     /locus_tag="C2142_RS33335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33410"
                     /product="LysR family substrate-binding domain-containing
                     protein"
                     /protein_id="WP_148646524.1"
                     /transl_table=11
                     /translation="MTEMQANPSFRLVYVPGVTPGKWVRVWEQRLPDVPLTLLAVPVED
                     GEPTLLGGGADAGLVRLPVDRGSLSAIPLYTETTVVVFPKDHWLAAAEEVPVADLADEV
                     VFHSMDDSLGWQDLPGRPAFERPATTADAIELVAANVGVLLVPQSLARLHHRRDLTYRP
                     VPDAPQSQVALSWLEERTTDLVEEFIGIVRGRTVNSSRGRAGAAQPEEKPATPGARPRG
                     TGAGKPAAGKSGGGRTAGGKTSGGKASGGRTAGGKASGGKSGGGRPGTGKAAGGKSGGA
                     RRGRPGR"
     gene            8225..8662
                     /locus_tag="C2142_RS33340"
                     /old_locus_tag="C2142_33415"
     CDS             8225..8662
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020550867.1"
                     /locus_tag="C2142_RS33340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33415"
                     /product="DUF5997 family protein"
                     /protein_id="WP_148646525.1"
                     /transl_table=11
                     /translation="MTSLKPKTTQTMKPATAAKKLGIYLDAAPADFQEGVVSREELNAL
                     QAEPPQWLQDLRRNGPHPRPVVAARLGVSVSGLARGGVAEALTTEQIDALKESNPDWLA
                     RERTIQAEVRREAVRVKEKHEKEQQKQAAPQATPAKSAKKR"
     gene            9160..9345
                     /locus_tag="C2142_RS33345"
                     /old_locus_tag="C2142_33420"
     CDS             9160..9345
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS33345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_33420"
                     /product="hypothetical protein"
                     /protein_id="WP_148646526.1"
                     /transl_table=11
                     /translation="MPDDGFVWYTGCRLERLTDDVGTFFTDWVAAPGFRDLAGLGPEDL
                     ATSHWYRLLRLTALAS"
     misc_feature    9442..9455
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.22"
                     /tool="antismash"
     misc_feature    9694..9709
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    9709..9724
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.28"
                     /tool="antismash"
     misc_feature    complement(9952..9965)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            10001..11047
                     /locus_tag="C2142_RS33350"
                     /old_locus_tag="C2142_33425"
     CDS             10001..11047
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000173: Biaryl bond formation (62% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145092.1"
                     /locus_tag="C2142_RS33350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33425"
                     /product="cytochrome P450"
                     /protein_id="WP_148646527.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 1e-185,
                     bitscore: 615.6, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 2.2e-12, bitscore: 45.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLSRTGGNTRATVFAPRIDALLRTYRGSDLFRLEDDTIGVAGVD
                     LMDSLLLSRPANDEERPTFKPVQGRSVPRTDASALMQAVSADVRAALKKPLGDSVDLTG
                     KWPHVAHVYLRDLVFGRESFRFRVLVDRRLELTPKLTWMAVAAGTAMLGKPGTEIPLSN
                     LAARVLNAETYDDRRYAMYLYRRVAAPVCFTVSALVTNALWLGSPFDEGVPNRDILLEA
                     LRLLPPSWNILRMASPEYLAVDDRIGPKDDILMLPLLTHRDPRLWDDPDTFRPERWAGL
                     DPDDQPGYLPFGHASERCWGRHMVMPLAERLLDIVRRDGLVVSPQQTVGKVELDGLLEV
                     AGVRMVRR"
     gene            complement(11164..11562)
                     /locus_tag="C2142_RS33355"
                     /old_locus_tag="C2142_33430"
     CDS             complement(11164..11562)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136304.1"
                     /locus_tag="C2142_RS33355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33430"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_148646528.1"
                     /transl_table=11
                     /translation="MSKVEIDALTAEFFGAFDNRGGKPADVARLRRLIVPGGVIVNTGP
                     SLTVYTVDEFIEPREQLLSDGRLVEFSEWETAERTEIVGDLATRFGEYGKSGIMNGEPY
                     EGGGTKAFQFVRTPEGWRIVSFSWSDHI"
     misc_feature    11580..11590
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.4"
                     /tool="antismash"
     misc_feature    complement(11635..11649)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            complement(11663..12217)
                     /locus_tag="C2142_RS33360"
                     /old_locus_tag="C2142_33435"
     CDS             complement(11663..12217)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006344911.1"
                     /locus_tag="C2142_RS33360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33435"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_148646529.1"
                     /transl_table=11
                     /translation="MPELIAPTVRLHAAWTRAHEEWGPGHHEDGFGLLPSDETASSEGF
                     AVWVARLADASGDPAEGVLAGGDPAVREALDRARCTYRWIVEGDEVLGGIALRHGNGDR
                     VPEFGHIGYGIRPSARRRGLATWALGRMLEEARGLGLDRVLLTCAVGNTASARTITRHG
                     GVFEGVRETRFGAVRRYWIEV"
     gene            12380..13129
                     /locus_tag="C2142_RS33365"
                     /old_locus_tag="C2142_33440"
     CDS             12380..13129
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557775.1"
                     /locus_tag="C2142_RS33365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33440"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_148646530.1"
                     /transl_table=11
                     /translation="MEQDQVWDDHAARNYDTPGTGMFAPEVLEPAVDRLAELAYGGRAL
                     EFAIGTGRVAVPLAGRGVPVTGIELSLPMIGRLRTKADEAEIPVVVGDMATARAPGAYT
                     LVYLVYNTISNLLTQSEQVACFRNAARHLAPGGRFVIELWVPELRRLPPGQPATVFHSE
                     PGYIGLDTYDVLQQHVVSHHFRFDGSRQAELFRSPHRYVWPAELDLMAQLAGFALESRH
                     ADWEGSDFTADSRSHVSVYRLPAAPER"
     gene            complement(13158..14585)
                     /gene="rox"
                     /locus_tag="C2142_RS33370"
                     /old_locus_tag="C2142_33445"
     CDS             complement(13158..14585)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene="rox"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992311.1"
                     /locus_tag="C2142_RS33370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33445"
                     /product="rifampin monooxygenase"
                     /protein_id="WP_148646531.1"
                     /transl_table=11
                     /translation="MFDVIVVGGGPTGMMLAAELQLAGVRTAVLDRLAEPFEFVRALGL
                     HARSVEVLDQRGLLEQFLALGRQHRVGGFFAGLGTSWPEGLDTAHSYVLGIPQPVTERL
                     LTEHAVGLGAEIRRGCELVGLSQDEDGVTAELADGTRLRSRYLVGCDGGRSTVRKLLGV
                     DFPGEPSRVETLLGEMQVTADPETLAAVSAEVRKTQTRFGFMPLGDGFYRVIVPAEGVV
                     EDRAAETTLDEFKEQLRAYAGTDFGVHSPRRLSRFGDATRLAERYRVGRVLLAGDAAHI
                     HPPTGGQGLNLGIQDAFNLGWKLAAEVNGWAPEGLLDSYHTERHPVAAAVLDNTRAQIQ
                     LMSVEPGPQAVRRLLSELMDFEEVNRYLIGKLIAIGLRYDFGEGHELLGRRMRDIGLKR
                     GRLYGLMHGGRGLLLDQTGRLSVAGWEDRVDHVVDVSDELDAPAVLLRPDGHVAWVGED
                     QQELLGALPTWFGAAAG"
     gene            complement(14808..15593)
                     /locus_tag="C2142_RS33375"
                     /old_locus_tag="C2142_33450"
     CDS             complement(14808..15593)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003956299.1"
                     /locus_tag="C2142_RS33375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33450"
                     /product="phosphotransferase"
                     /protein_id="WP_148646532.1"
                     /sec_met_domain="APH (E-value: 4.9e-09, bitscore: 35.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDREVLAGGVNHVVREGDRVRRPAGPWSGTVQRLLAHLADTGFT
                     GAPRPYGLAADGAEEIVGYLPGEVGHDFGAPQVRSDASLVAVARLLRRLHDATAGFARE
                     PGDVWYFPAREPAEVICHGDAATYNTVFRDELPVAFIDFDTAHPAPRLWDAAYTAYRFV
                     PLYAPDEVELTLEVPEALRRLALFADGYGLSGAERAELPRVAAERLRALVAWMHEQAEA
                     GHPAFARHVAEGHDRRYLTDADWIEGTFAAPAGPVNGGH"
     misc_feature    15691..15706
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.53"
                     /tool="antismash"
     misc_feature    complement(15695..15708)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.27"
                     /tool="antismash"
     misc_feature    15696..15710
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.32"
                     /tool="antismash"
     misc_feature    complement(15797..15815)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.35"
                     /tool="antismash"
     gene            15815..17104
                     /locus_tag="C2142_RS33380"
                     /old_locus_tag="C2142_33455"
     CDS             15815..17104
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008736815.1"
                     /locus_tag="C2142_RS33380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33455"
                     /product="MFS transporter"
                     /protein_id="WP_148646533.1"
                     /transl_table=11
                     /translation="MIAKSAGLRIPGLAGPSGPQRALILASFVNRVGNGLFNTASVLYF
                     TLVVHLPAARVGVGLTVAGLVGLLAGIPAGNLADRYGPRTVWLTAFATQAAAMAAFVFI
                     DDWITFTLIATLDRLAATAGGAAGGALIARAGGERPAAFMAKLRTFVNLGVVLGTAGAA
                     FAVAVDTRAAYTVLILANAASFACAGLIALGGVPNYRPLPRPEEHRRWAVLSDRPYVSF
                     VALYGAMGLQYQTVSLLLPIWLSAHTDAPRWTVAAVSAVNSGVCVLLQSRIGSRVETPR
                     QGGRAFRLAGLLFLVSCPLMALTADVPAWVAPGLAVLAVCVHSLGEVWESSGGYALGFG
                     LAPDHAQGQYQGFFGVGFNAGQALAPVVLTTAVLGLGHAGWLLLGAFFAAVGAAGPPVT
                     AWAERTRRPGGDTAGTADSRPDEAPLPETA"
     gene            17149..18012
                     /locus_tag="C2142_RS33385"
                     /old_locus_tag="C2142_33460"
     CDS             17149..18012
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (2-127). E-value: 2e-15.
                     Score: 49.0. Matches aSDomain:
                     nrpspksdomains_C2142_RS33385_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048405.1"
                     /locus_tag="C2142_RS33385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33460"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_148646534.1"
                     /sec_met_domain="PF00561 (E-value: 1.5e-09, bitscore: 36.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.4e-15, bitscore:
                     56.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQPTFVLVHGAFANSFSFAPLQAELGLLGHRSVAVDLPGHGFAAT
                     YPRAYQAPQDLGGLATEPGAIKGVTLADNAAHLIGILERAKRNGPVVLVSHSRGGITAT
                     VAANRRPDLIDHIVYVSSWCPVTLDVGAYYAEPEMATVDAAGLASAMVANPAELGLLRS
                     NFRTADPGVLAAFKAAFLADGTDEELLVFLNTLQPDENLDAGTSDDRAQADTWGRIPRS
                     YVRLTEDTSVPLTMQDRMIREGDALTPKNPYDVRTLTSSHLKWLVDPAPAARVLGEIAA
                     LLPAGS"
     aSDomain        17155..17529
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS33385_Abhydrolase_1.1"
                     /evalue="2.00E-15"
                     /label="C2142_RS33385_Abhydrolase_1.1"
                     /locus_tag="C2142_RS33385"
                     /protein_end="127"
                     /protein_start="2"
                     /score="49.0"
                     /tool="antismash"
                     /translation="PTFVLVHGAFANSFSFAPLQAELGLLGHRSVAVDLPGHGFAATYP
                     RAYQAPQDLGGLATEPGAIKGVTLADNAAHLIGILERAKRNGPVVLVSHSRGGITATVA
                     ANRRPDLIDHIVYVSSWCPVT"
     gene            complement(18214..18420)
                     /locus_tag="C2142_RS33390"
                     /old_locus_tag="C2142_33465"
     CDS             complement(18214..18420)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006603716.1"
                     /locus_tag="C2142_RS33390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33465"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_148646535.1"
                     /transl_table=11
                     /translation="MNSDLSGASWAKSSYSDNGGQCVEVSASFPGAVPVRDSKDPEGPA
                     LVFPRAAWQSFVAGVQAGEFGAV"
     gene            complement(18417..19247)
                     /locus_tag="C2142_RS33395"
                     /old_locus_tag="C2142_33470"
     CDS             complement(18417..19247)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006348721.1"
                     /locus_tag="C2142_RS33395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33470"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_162002612.1"
                     /transl_table=11
                     /translation="MKHSESDASSSALVRFGAELRRSRRAMRWSQTELGRRMGYSNAMV
                     SYVERAKKAVTSNFAVKADEVFETGGTFHELWCRYSKASLLEGFPEFADAEARCRRLRE
                     FALTIVTGLFQVPGYAEALAYAAVERGAITQSAAEQRVEFLAARQRVLDRKKPPLIHAV
                     LDESCLVRPIGGQAVMLEQLEHIADLAARPNVTLQVAPFHLGENLPFKMPVTLLDLPDG
                     TVVGYAESHARGHLERARETVVAWEREYDQLVVEALPKAASLALIHKARKELAP"
     gene            19374..19628
                     /locus_tag="C2142_RS33400"
     CDS             19374..19628
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS33400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162002613.1"
                     /transl_table=11
                     /translation="MSSCPRMPVYTPKVGEIVRDLAHRTADGEPAEGVHMETLAGLAYL
                     RPVGGGCEWTTKPEHVQRLDHPHDVTVQHPGRPRAHDVA"
     gene            19840..20328
                     /locus_tag="C2142_RS33405"
     CDS             19840..20328
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.4"
                     /locus_tag="C2142_RS33405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX hydrolase"
                     /protein_id="WP_162002614.1"
                     /transl_table=11
                     /translation="MLYPLPDILTNPPRRRLDHQALVLNSDGAVLLLETTLRNGHTLPG
                     GSAERNELPHLAARRHTETQTGLVLPLRTLLAADHTDEQLLPEAVHFVYWGGRLTRAQE
                     TTLTRHRPPDHVLGLHWVPDTRLADVMTTGQHRRVTQALTALARGAHLPFLLRGIPAR"
     gene            20569..20982
                     /locus_tag="C2142_RS33410"
                     /old_locus_tag="C2142_33480"
     CDS             20569..20982
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016641920.1"
                     /locus_tag="C2142_RS33410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_33480"
                     /product="VOC family protein"
                     /protein_id="WP_148646538.1"
                     /transl_table=11
                     /translation="MLRLTDFIIDCPDTMKLAAFYSEVTGLPVKESSNEHWAGIQFGGI
                     ELAFIQVEDYRAPQWPDSEHPKQFHLDFEVDDIEAEQHRVLALGATLQRDCIEPDGYGF
                     RVYTDPIGHPFCLCRNKGVIWTDQGPVWPKHDQ"
ORIGIN
        1 cgccacgcct cggcggcgat ctcgcgcggg cccacccgta cccggaaacc gccgaggaga
       61 cggatacgca gttcgagcat gcgccggacg ccttccgtgc ggacactacg aacctacgtc
      121 ggcaacgccc cacgggcgag tccgggcgcg gcaccaccgc cggagcaccg cacgtcaggc
      181 ccccacatgt caggccccgc gcgtcacttc ccgcacgtga ctcccccgcg cgccggcctc
      241 ggccgcacac caccgggtca cgccatcgcg tcacgccatc gcgtcacgcc accgggtcac
      301 gccgccggat cacgtaaccg tgtcacggaa ccgcttcact ccgccggatc acgtaaccgc
      361 ttcacgccgc cgcgtcacgt cacggcgtca cgcctcggac agcgccgacg tcccgaactc
      421 gcgcaccgcg tcggccacga tggcgtccag gctggcgtgg tgggcgcccc gccagtacgc
      481 ctggccgcat tcggtgcact gcgcgaacgc gtcgtacgag cgctcggtgc cgtcccggag
      541 ctggtcctgc accgtcgact tggtgacgga gcgcagcaca ccgttgcagg tggtgcaccg
      601 gctccagggg gcgagcggcg gcgcgaaccg ggacaggacg tcccgcagct gttcggcggg
      661 ccggtggctg tagacgtagg cgccggccca gagttcgcgg cgccgcagca ggccgcggtc
      721 gcgcgagagc atgacgcgct gttcggcggc cgagcgggcg gcgagcgcgg cgtcgccgat
      781 gtccgggttc tcgtaggcgg cgtcgatgcc cagcagccgc agtcggcgcg tcagcgtgcc
      841 gaggtggacg tcgagcagga accggacggg ggcggccgcg ggctgcggcc tgggtaccgc
      901 ctccaccgag atccgctcgc caccggcggg ggcgtacccg acgcccaccg gccgaccgtc
      961 cgcgaccagg gcgccgacct cggtgagcgg gacgccgagc gactcgacca cgtgcccgag
     1021 cgtcgaggca ccgtcggttc gcagcgccgt gggcgccccc cgccgcgccg aggcgacgaa
     1081 gaggtgcagc tcgggggcga agctgagcca gatctccggt ctctccaccc ggccagcatg
     1141 ccagcgggcg gccgccggcg gccagcgctt ttcccgccgt cggtcaggcc gccggtcggt
     1201 ccgccggccc ccgtcggcac acgggaggcc gccgtccggc ggtccagcgg tccagcggtc
     1261 cggcgcggtc aggcgtgcgg cgcccagaag gcgaccaggc ggccggcacc gtgctcgacg
     1321 ctcttccagg agccggtgaa ggtgagcacc gcgacggcgg aggtggggaa gccggagcgg
     1381 ttcatcctgg cgagcagatc gccgtcggcc tcgccggcga gggcgtcggc cagggcgtgg
     1441 gcgcccgggt tgtggccgac gaggacgacg tcggccacct cgtcggacac ctcgttgagc
     1501 agggcgatga tttcgccgag gctcgcctcg tagagccggt cctcgaagac gctcctgggc
     1561 cgctggggca gctcggggac catcagcttc caggtctccc gggtccggac cgccgtggag
     1621 acgagtgcga ggtcgggctc gatgcccgca ccggccagcc aacggccggc gacgggtgcg
     1681 tccttgcggc cctggtcggc cagcgggcgc tcgtggtcgt cgacgtcgct ccactcggcc
     1741 ttggcgtgcc ggaccacgac gatcctacgg gtcggttcgg cgctcacgac ggtctcctct
     1801 tcgtacgggg atcgataccc ggccgacgct acccaccggg tcttcccgtc accggcacga
     1861 cagccgcccc tcacccgaag aggtgagggg cggcgggcgg caggatcagc ggaaggtgcg
     1921 gagccggagg ctgttgccga ccacgaagac cgaggagaag gccatcgccg cccccgcgat
     1981 catcgggttg agcagcccgg cggcggccag gggcagggcg gcgacgttgt agccgaaggc
     2041 ccagaagagg ttgcccttga tggtggccag ggtccggcgg gagagccgga tggcgtcggc
     2101 ggcggccagc aggtcgcccc ggacgagggt gaggtcgccg gcctcaatgg cggcgtcggt
     2161 gccggtgccc atggccaggc ccaggtcggc ctgggcgagg gcggccgcgt cgttgacgcc
     2221 gtcaccgacc atggcgacga cccggccctc ggcctggagg cgctgcacgg tggcgacctt
     2281 gtcctgcggc agcacctcgg cgatcacgtc ctccggcctg atgccgacct cggccgccac
     2341 ggtcgcggcc acggcggcgt tgtcgccggt gagcagcatc ggggtcagtc cgaggccgcg
     2401 cagccgggcg atggcctcgg cgctggtggg cttgacggcg tcggcgacct ccagcacggc
     2461 ccgggcctcg ccgtcccagc cgacggcgat ggcggtccgt cccgcggcct cggcacggcg
     2521 cttggcctcg gccagcggcg ccgacaggta ctgcgaccag tcggcgagca gctgctcgcg
     2581 gccgaccagc accgcgtgtc cgtccacgac gccttggacg ccgagtccgg ggacgttctc
     2641 gaagccctcc acggcgggca gctcgcccgc cttccgggca gcggtggcga cggcgcgggc
     2701 gatcgggtgc tcggaggcgt gctccagggc gccggccagg cgcagcgcct cggcctcggt
     2761 gacgccctcg gcggcgtgga cggcgagcag ggtcatctgg ccggtggtga cggtgccggt
     2821 cttgtccagg acgatggtgt ccacccggcg ggtcgactcc aggacctcgg ggcccttgat
     2881 caggatgccg agctgggcgc cacgcccggt gccgaccagc agtgcggtcg gggtggccag
     2941 gccgagtgcg cacgggcagg cgatgatcag cacggcgacg gcggcggtga aggcggcggc
     3001 ccagccctcg ccggtgccga gccagtagcc gagggtggcc agggccaggg tgatgacgat
     3061 cggcacgaag acggcggaga tccggtcggc cagccgctgg gcggcggcct tgccgttctg
     3121 ggcgtcctcc accagcttgg ccatccgggc cagttgggtg tcggcaccga cccgggtggc
     3181 gcggacgacg agccggccgc cggcgttgac ggtggcgccg gtgacggagt cgccgacggc
     3241 gacctcgacc ggcacggact cgccggtcag catcgacgcg tccacggcgg aggcgccctg
     3301 ctcgatcact ccgtcggtgg cgatcttctc gccggggcgg accacgaaca gctcgccgac
     3361 ggcgagttcg gcggtcggga tgcggacctc ggcgccgccg cgcagcacgg tgacgtcctt
     3421 ggcgccgagt tcgagcagcg ccttcagcgc ggcgccggcg gtgcgcttgg accgcgcctc
     3481 gaagtagcgg ccggccagga tgaacgcggt gacgccggcc gcggcctcca ggtagatgtt
     3541 ggacgagccg tcgctgcggg cgatggtgaa ctcgaagccg tgccgcatcc ctggcattcc
     3601 ggcgttgccg aggaacaggg cccagagcga ccagaggaac gcggcgccgg tgccgagcga
     3661 gaccagggtg tccatggtcg ccgcgccgtg ccgggcgttg gtccaggcgg cccggtggaa
     3721 cggccaggcg gcgtaggtga cgacgggcgc ggccagggtg agcgagagcc actgccagtt
     3781 gtcgaactgg agggccggca ccatggccat cgcgatgacg gggacggcga gggccagcgc
     3841 ggtgatcagc cgctgccgca gcggggcgag ttcgtccgcc tcggcggccc cggccgcggc
     3901 gccggcgggc tcggtggcgg cggggcgggg caggacggcg gtgtagccgg tggcctcgac
     3961 ggtggcgatc aggtccgcca cctcgacgcc gtccaccacg acgaccttgg ccttctcggt
     4021 ggcgtagttg acggtggcct cgaccccgtc catgcggttg agcttcttct cgatccgggc
     4081 ggcgcacgag gcgcaggtca tgccgccgat ctggagttcc acctcggtgg aggcgagtgc
     4141 ctgggtggtc atctgggctc ctcgtgggtc gtggatcaga gtggttcagg tccggccctg
     4201 gccttccggg cctgctcccg gccgggctcc gggatacccc ccaggggttt tccggacccc
     4261 ggcggccggg gcgggcggcg ggctcaggcg cggccggtca gctcgtagcc cgcgtcgtcg
     4321 atcgcggcgc gcagggccgc ctcgtccggc tcggcctcgg ccgagacggt gaccaggccg
     4381 gcctggacgt cgacgctcac ggcggtgacg ccggccaggg cggaaaccgc cttgccgacc
     4441 gcctgctcgc agtggccgca ggtcatcccg gcgaccgcgt agacggtggt gacggcggca
     4501 gcgggcgcct cgaccgtggc ggtggtggag caggtgccgt tctcggagca gcaggacatg
     4561 ggattcctcc ggtggtagca gtgccgttgc tcgataccca gtgggggtat cggtcggtgc
     4621 gtagttcctt tatacccctg gggggtatca ctggcaaccc ccgccgaccg gcgcgaacct
     4681 tccgcaccaa gtactcccca ggggtaccta cggggagagt cgatcccgct tgacgcaata
     4741 ccccctaggg gtatctactg caggcatcga agcgcccacc cgacaaccgg aggaggcccg
     4801 catggccggc taccacgacg acaaggacca ggtaatgcgc aggctgcgcc gcatcgaggg
     4861 ccaggtgcgc gggctccagc ggatggtcga cgccgacgac tactgcatcg acgtcctcac
     4921 ccaggtctcg gcgaccacca aggccctcca gtcggtcgcc ttgcaactgc tggacagtca
     4981 cctcggccac tgcgtccagg acgccatcgc ccggggcggc ggcgaggccg acgccaaggt
     5041 cgccgaggcc tcgaacgcca tcgcccgcct gatgcgcgcc tgagcaccgc ccgcccggcg
     5101 ccgcacgccc ccccggtcaa tcccggccaa tccccgccac gcccccgcac acggccgcac
     5161 ccacgcccgc tcccgaagga gctccgccat gaacaccgca ctgaagatcg ccgccttcgc
     5221 caccggcctc accaccgcgt tcggcgccgc gtacggggtc ggccacgcca ccggtaccgg
     5281 cccggcaccg cgcccggccg cggccgccca caccggccac accggccacg ccgcggaggc
     5341 cccagccggg gccgaggctg cgggcgacca cctgcccggc ggtctccagg tctccgaacg
     5401 cggctacacg ctcagcctcg acagcccctt cgtgaccgcc ggcgccccga ccgacctgcg
     5461 gttccgcatc ctcggcgcgg acggccgccc ggtcaccgac taccgcccgg agcacgagaa
     5521 ggagctgcac ctgatcgtcg ccccgcgcga cctcgccacc ttccagcacc tgcacccgac
     5581 gcgggccgcc gacggcacct ggagcgcggc gaccgccctg ccggccgcgg gcgagtaccg
     5641 ggtcttcgcc gacttcaccc cggccggcgc cgccgagggg ctcaccctcg gcaccgacct
     5701 ccacgcggcc ggcgacctgc gccccgcgcc cctgccggag accggacgca gcgtcgccgt
     5761 cgacggctac accgtcaccc tcggcggcga cctcaccccc ggccggcccg cccggctcac
     5821 cctcaccgtc accaaggacg gccggccggt caccgacctc cagccctacc tcggcgccta
     5881 cggccacctg gtcgccctgc gcgccggaga cctcgcctac ctccacgtcc acccggagag
     5941 cacgacgccc gggccggagg tcgccttcac cgcgaccgcg cccagcccgg gcgcctaccg
     6001 tctcttcctc gacttcaagc acggggacac cgtccgcacg gcggccttca ccgtcgccac
     6061 cggggacggc gccgccccgg ccaccgcagc cccgtcgacg gctgcggccc cgtcgacgac
     6121 cgcagccccg tcgaccgctc cggagggggc tcaccagcac tgaacgaccg gagcacctgg
     6181 gccggaggcg cctccgccgg gacacctctg ccgggggcgc ctccgccgag aaacctccgc
     6241 cgggacacct ctgccgggtg agcggcttca cccggagcgg ctcacccgaa gcgcttcagc
     6301 agctcctcga cgtactcctc cagccgcccg gcgaggagcg cgggggtcag gtcggtccgg
     6361 ccgagctcgc gccagctcac ccccaccttc tccgcgtcgg gggcgaaggc gagggcgtcg
     6421 agcaggcgcc agtacaggtg gtcggccggc tccaccgcga ggtccccgcc ggcctccagg
     6481 taacggccgg cgaacgccat cccggccggc acgccgtaca gcagggccaa cgcggtggag
     6541 cagtgcgcga cgtccaggtc ggcggggccc caggaggtct ccacccagtc caccacaccg
     6601 gtgatccgca gctcgcccgt actcccgccg ccgctgaaca gcacgttgcc cgggtggtag
     6661 tcccggtgca ggaagcggcc cgggaacgac ggcggcgggc ggcggatcac ctccaccgcc
     6721 cgctcccaca cctccggacg cgcgctcccc gccgggcgcc gcacgccctc cggggtcacc
     6781 cacgcctggt agtcccgcgg ccgcgcgtgc tccggcacgt cgacgcggtg gatccgggcc
     6841 agttgcccgg cgagcagccg gcagcgctgg tccagctcct cctcgtccac ccggacggtg
     6901 cccggcagca gcgtcatcag cagcgacggg tacgcgcaga actcccccgt cgcatccacc
     6961 ccgcgcagcg tggccaccgg cacgccgccg ccgtccgcgc cgagcagggt gaggatgtcg
     7021 gcctccctgg tgagcaggcc ttcggcatgc cggaggtaga acggcgcgac gaacgagcgg
     7081 agcaccaact cctctgcgcc ctccgggcct tcgacgcgca gtcggcgcat ctccgaggtg
     7141 aacccgcccc gcagccgact gcccccggtc accctgctgc cgtcggccaa ccgcccctcg
     7201 acccatgccc acgtccggtc ccggtcccgg tcccggttcc gctgcgcatc gtcgtgcgcc
     7261 actaattcgc tcatggccgt cgagcctagg cgaggcccga ctacctcccc ggacggcccc
     7321 ggcgggctcc gccggacttt ccgcccgccg ccttgccggt acccggcctg cccccgccgg
     7381 acttcccgcc cgacgccttg ccgccggccg tcctgcctcc cgacgccttg cctcccgacg
     7441 tcttgccacc ggccgtcctg ccgccgcccg acttcccggc ggccggcttg cccgcaccgg
     7501 tgccgcgcgg ccgggcgccc ggcgtcgcgg gcttctcctc gggctgggcg gcgcccgcgc
     7561 ggccgcggga gctgttgacc gtccggccgc ggacgatgcc gatgaactcc tccaccaggt
     7621 cggtcgtccg ctcctccagc caggagagcg ccacctggga ctgcggcgcg tccggaacgg
     7681 gccggtaggt gaggtcccgg cggtggtgca gccgggcgag cgactgcggc acgagcagga
     7741 cgccgacgtt cgccgcgacc agctcgatcg cgtccgccgt ggtcgccgga cgctcgaatg
     7801 cgggccgccc gggaaggtcc tgccagccga gggagtcgtc catggaatgg aagacgacct
     7861 cgtcggccag gtccgccacc ggcacctcct cggccgccgc cagccagtgg tccttcggga
     7921 agacgaccac ggtggtctcg gtgtagaggg ggatcgcgct gaggctgccg cggtcgaccg
     7981 gcagccggac gagcccggcg tccgcaccgc cgcccagcag cgtgggctcg ccgtcctcca
     8041 ccggcacggc gagcaaggtg agcgggacgt ccggcagccg ctgctcccag acgcgcaccc
     8101 acttaccggg cgtcacgccg ggaacgtaca ccagccggaa cgaggggttc gcctgcatct
     8161 ctgtcacgca gcaaggctac cgaccgtgat cggggccgcc actcactcgc ttaccctagt
     8221 gaccatgaca tcgctcaagc cgaagaccac ccagaccatg aagccggcca cggcggccaa
     8281 gaaactgggc atctacctcg acgccgcccc tgccgacttc caggagggcg tggtctcccg
     8341 cgaggagctg aacgccctgc aggccgagcc gccgcagtgg ctccaggatc tgcgccgcaa
     8401 cggcccgcac ccgcgcccgg tcgtcgcggc caggctcggc gtctccgtct ccggcctggc
     8461 ccgcggcggg gtcgccgagg ccctcaccac ggagcagatc gacgccctga aggagtccaa
     8521 cccggactgg ctggcgcgcg agcgcaccat ccaggccgag gtccgccggg aggccgtgcg
     8581 ggtcaaggag aagcacgaga aggagcagca gaagcaggcg gccccccagg ccacgccggc
     8641 caagtcggcc aagaagcgct gacgcacacc ggtcggccgg ctccggcggg caccggaccg
     8701 ccgggccggg gctgaccggg acgacgggcg ggccggtgcc ccggggcgtc cggcgccgac
     8761 gcccgggcag cggcccacac gtccgcaggg ggatccgcat gacgaacgac cgcgtcggcc
     8821 tggccgccct cacggagttg ctgcgcgcag cgcacgccga gcaccgccac cggctggggc
     8881 tctgggactg cgaccttccc gcccgcgccg agcgcagccg tatccccgcc gggacacccg
     8941 tcgccgtggc ggacctgctg gccgcctccg acggcctacc tgaaccactc cacccggttc
     9001 ttccccgcgg acgagctcga cgggcagcag ttctccgaag gcctggtcgg cgccgagctg
     9061 cccggcggtg caccactcga tgacgcctcg cgcttccact tcttcggccg ggcccgcggg
     9121 aacccgctgc tggtcgaccg cgacgggagc gtctggcggg tgcccgacga cggcttcgtc
     9181 tggtacaccg gctgccggct ggaacggctc acggacgacg tcgggacctt cttcaccgac
     9241 tgggtggccg cccccggctt ccgcgacctg gccgggctcg ggcccgagga cctcgcgacc
     9301 agccactggt accggctgct ccggctgacc gccctggcct cgtgacgccc cgccccggcc
     9361 ggccatcccg tcccggcacc ggccggcgaa cgcccctgcc cgcccccgtc cggccctgac
     9421 atgtcgcatg cccgaaaggg cagaccgaac gttccgtcgg cccgtgccgc gtctcccgga
     9481 atcccgtcag gacgtcccgc cgccgggccg cggacgcgtg ccgttcatgc ggccgccacc
     9541 cggggcgagg cgctgaccag cgccgtcgcg caccccgcgg ccccttacaa ccgccccgat
     9601 gggcacgatg cgcccagggc cgttcatttc gcaccccagg cggtcgaatc gggcgcgggg
     9661 aaacgcgaaa cccgccggca ccgccgaccg gcgtgtgaac tgcgtcactt gacgcttatt
     9721 tcgtgctggg cttcactttt tccggcgacg agaagcggaa cgcagaattc tgcggactta
     9781 cccaccgccc cccgtcggcc tttgcatgat tcgtccggtt cactctcaga cggaggtact
     9841 gtcatgaagc tcgtgcattt cgtgaagaag gtcatgccgg agaagagcct gaaggcctac
     9901 gcctggtacg gctggatcta atcgggcagt tcgctgccag gcccgtgccc ggtggaatcg
     9961 gtccacccgg gcacgggccg ctcacccttg gagttcaccg atgtctctgt ccaggaccgg
    10021 cgggaacacc cgggccaccg tcttcgcgcc gcggatcgac gcgcttcttc gcacgtaccg
    10081 cgggtctgac ctcttccgcc tggaggacga caccatcggg gtcgcgggcg tcgacctgat
    10141 ggacagcctg ctcctcagca ggcccgccaa cgacgaggag cggccgacct tcaaacccgt
    10201 ccaggggagg tccgtccccc ggaccgacgc gtccgcgctc atgcaggccg tctcggccga
    10261 cgtccgggcc gcgctgaaaa agcccctggg cgattcggtc gacctcaccg ggaaatggcc
    10321 gcacgtcgcc cacgtctatc tcagggatct cgtcttcggc cgcgagagtt tccggttccg
    10381 cgtcctcgtg gaccgccggc tggaactcac cccgaaattg acctggatgg ccgtggcggc
    10441 cggcacggcc atgctcggaa agccggggac ggaaattccg ctgtccaatc tggcggcccg
    10501 cgtgctgaat gcggaaacct atgacgaccg ccggtacgcg atgtacctgt accggcgggt
    10561 ggccgcgccg gtctgcttca ccgtgtccgc gctcgtcacc aatgcgctct ggctgggctc
    10621 gcccttcgac gagggcgtgc cgaaccggga catcctgctg gaggcgctgc ggctgctgcc
    10681 cccgtcctgg aacatcctgc ggatggcctc cccggagtac ctcgccgtgg acgaccggat
    10741 cggcccgaag gacgacatcc tgatgctccc gctgctgacc caccgggatc cgcggctctg
    10801 ggacgacccg gacacgttcc gccccgaacg gtgggccggc ctcgaccccg acgaccagcc
    10861 cggctacctc cccttcggcc acgccagcga gcgctgctgg gggcggcaca tggtcatgcc
    10921 gctggccgag cggctcctcg acatcgtgcg ccgcgacgga ctcgtggtga gcccgcagca
    10981 gaccgtcggg aaggtcgagc tcgacggcct gctggaggtc gccggggtgc ggatggtccg
    11041 gcgttgaccg ggggcggcgc caccggctga cgagccggtg gcggaggcgc cgccgacgca
    11101 ggggctcccc ggccgtggtt ccggcccggg gagcccaacg gcgtccactg agatgacggt
    11161 ccgtcagatg tggtcggacc aggagaagga gacgatccgc cagccctcgg gggtacggac
    11221 gaactgaaag gccttggtcc cgccaccctc gtacggctcg ccgttcatga tcccggactt
    11281 gccgtactcg ccgaagcgcg tcgcgaggtc gccgacgatc tcggtgcgct cggccgtctc
    11341 ccactcggag aactcgacca gccggccatc gctcagcagc tgctcgcggg gctcgatgaa
    11401 ctcgtccacg gtgtagacgg tcaggctcgg gccggtgttg acgatcactc cccccggcac
    11461 gatcagccgg cggagccggg cgacgtcggc gggcttgcca ccccggttgt cgaaggcgcc
    11521 gaagaactcg gcggtcagcg cgtcaatctc gaccttggac atgagcggaa cagtaacact
    11581 gcaatgtcac cgaggcccag gtccgccagg tctcgatccg tccgtcaggc ctcgatccac
    11641 acgtcagatc tcggcccctc cgtcagacct cgatccagta gcgccgcacc gcaccgaacc
    11701 tcgtctcccg gacgccctcg aacacgccgc cgtgacgcgt gatcgtcctc gccgaggcgg
    11761 tgttcccgac cgcgcaggtg agcagcaccc ggtccaggcc cagcccccgc gcctcctcca
    11821 gcatccggcc cagcgcccag gtcgccagtc cgcgccgacg cgcggacggc cggatgccgt
    11881 agccgatgtg gccgaactcc ggtacccgat cgccgtttcc gtgccgcagc gcgatcccgc
    11941 cgaggacctc gtcaccctcg acgatccaac ggtaggtgca ccgcgcccgg tccaacgcct
    12001 cccggaccgc cgggtcacct cccgccagga caccctccgc cgggtcgccc gacgcgtccg
    12061 ccaaccgcgc cacccagacg gcgaacccct cggacgatgc ggtctcgtcg gacggcaaca
    12121 gcccgaaccc gtcctcgtgg tggccgggcc cccactcctc gtgcgcccgg gtccaggcgg
    12181 cgtggaggcg gacggtgggc gctatcagtt cgggcatacg gcgacgatac ccaccggcac
    12241 cggcgcgatc cacggcccgc ccggccgcgg gccgttgacg ccccggaccg ccccggaccg
    12301 ccccccgatc acccccggat catccccggg gccgcaaaag cgttggacaa ctcgcctgcc
    12361 gttgcacacc gttgagggaa tggaacagga tcaggtctgg gacgaccacg ccgcacggaa
    12421 ctacgacacg ccgggcacgg gcatgttcgc ccccgaggtc ctggagccgg ccgtggaccg
    12481 cctcgccgaa ctcgcctacg gcggacgggc gctggagttc gccatcggca ccggccgggt
    12541 ggccgtcccg ctcgccgggc gcggtgtgcc cgtgaccggc atcgagctct cgctcccgat
    12601 gatcggccgg ctccgcacga aggcggacga ggcggaaatc ccggtggtcg tcggcgacat
    12661 ggcgacggca cgggccccgg gggcgtacac gctcgtctac ctcgtctaca acacgatctc
    12721 caacctgctc acccagtccg aacaggtcgc gtgcttccgc aacgccgccc gccacctcgc
    12781 gcccggcggc aggttcgtga tcgagctctg ggtacccgag ctgcgcaggc tcccaccggg
    12841 ccaaccggcg acggtcttcc actccgagcc cgggtacatc ggcctcgaca cgtacgacgt
    12901 cctgcaacag cacgtcgtgt cccaccactt caggttcgac ggcagccggc aggccgaact
    12961 cttccgcagc ccgcaccgct acgtctggcc ggccgaactc gacctcatgg cccaactcgc
    13021 cggcttcgca ctggagagca ggcacgcgga ctgggagggc tccgacttca ccgccgactc
    13081 gcgctcccac gtctcggtgt accgcctccc ggcggccccg gagcggtagg actccggggc
    13141 cctgcacggc cgcacgctca gccggcggcg gcgccgaacc acgtcggcag cgcgccgagc
    13201 agctcctgct ggtcctcgcc gacccacgcc acgtggccgt ccggccgcag cagcaccgcg
    13261 ggcgcgtcca gctcgtcgct gacgtcgacc acgtggtcga cccggtcctc ccagccggcc
    13321 accgagagcc ggccggtctg gtcgagcagc agaccgcggc cgccgtgcat cagcccgtag
    13381 aggcggcccc gcttcagccc gatgtcccgc atccgccggc cgagcagctc gtgcccctcg
    13441 ccgaagtcgt agcggagccc gatcgcgatg agcttcccga tcaggtaccg gttcacctcc
    13501 tcgaagtcca tcagctccga cagcagccgg cgcacggcct gggggccggg ttcgacggac
    13561 atcagctgaa tctgtgcgcg ggtgttgtcc aggacggccg cggccaccgg gtgccgctcg
    13621 gtgtggtagc tgtccagcag cccctccggt gcccagccgt tcacctcggc ggccagcttc
    13681 cagccgaggt tgaacgcgtc ctggatgccg aggttgaggc cctgcccgcc ggtcggcggg
    13741 tggatgtgcg cggcgtcgcc ggccagcagc acccggccca cacggtagcg ctcggccagc
    13801 cgggtggcgt caccgaagcg ggagagccga cgcggcgagt gcacgccgaa gtcggtgccg
    13861 gcgtacgccc gcagctgctc cttgaactcg tcgagggtcg tctcggccgc gcggtcctcg
    13921 accaccccct cggcgggcac gatcacgcgg tagaacccgt ccccgagagg catgaagccg
    13981 aagcgggtct gggtcttgcg gacctcggcc gacaccgcgg ccagggtctc cgggtccgcc
    14041 gtgacctgca tctcccccag cagcgtctcg accctgctgg gctcgcccgg gaagtccacg
    14101 ccgagcagct tgcgcaccgt gctgcggccg ccgtcgcagc cgaccaggta gcgcgaacgc
    14161 agccgcgtgc cgtcggcgag ctcggcggtc accccgtcct cgtcctggct cagcccgacc
    14221 agctcgcagc cgcgccggat ctcggcgccg agcccgacgg cgtgctcggt cagcaggcgc
    14281 tcggtgacgg gctgcggaat accgaggacg tacgagtggg cggtgtccag cccctcgggc
    14341 cacgaggtgc cgagcccggc aaagaaaccg ccgaccctgt gctgccggcc cagcgcgagg
    14401 aactgctcca gcaggccgcg ctggtccagc acctcgacgc tgcgcgcgtg caggcccagc
    14461 gcccggacga attcgaaggg ttccgccaac ctgtcgagca cggccgtacg caccccggcc
    14521 aactgcagct cggcggccag catcatcccg gtcggtccac cgccgacgac gatcacgtcg
    14581 aacatcaaaa gcccccattg atttccgcag gccccggatt tccgcaggtc ctggcaacgg
    14641 tcggcaattc tgcgccacga agggggcctt gccgcaaggc cccccgtacg ctataagttg
    14701 agagtggcgg agagtgggtg tacctcccgt cccgatcccg gaattcctcc cgtcccggaa
    14761 ttcctcccgt cccggaattc ctcccgtccc ggaattcctc ccgcccttca gtgtccgccg
    14821 ttaacgggcc cggcgggcgc cgcgaaggtg ccttcgatcc agtccgcatc ggtcaggtag
    14881 cggcggtcgt gaccctccgc gacgtgccgc gcgaacgcgg ggtgaccggc ctccgcctgc
    14941 tcgtgcatcc acgccaccag cgcccgcagg cgctcggccg cgacccgggg cagctcggcc
    15001 cgctccgcgc cggacagccc gtagccgtcc gcgaacaggg ccagacggcg cagggcctcc
    15061 ggcacctcca gcgtgagctc cacctcgtcc ggagcgtaga gcggcacgaa gcggtacgcc
    15121 gtgtaggccg cgtcccagag ccgcggagcc ggatgtgcgg tgtcgaagtc gatgaaggcg
    15181 accgggagtt cgtcgcggaa caccgtgttg taggtggccg cgtcgccgtg gcagatcacc
    15241 tccgccggct cgcgcgccgg gaagtaccac acatcgcccg gctcgcgcgc gaagcccgca
    15301 gtggcgtcgt ggagccggcg cagcagccgg gccaccgcca ccagcgaggc gtcgctgcgt
    15361 acttgggggg cgccgaagtc gtgcccgacc tcgccgggca ggtacccgac gatctcctcc
    15421 gcaccgtccg cggccagccc gtacggcctc ggcgcgcccg tgaaccccgt gtcggccaga
    15481 tgcgcgagca gccgctgcac cgtcccgctc catggcccgg ccgggcggcg cacccgatcc
    15541 ccttcccgga ccacgtggtt gactcccccg gcgagcactt cgcgatcttc catcggggca
    15601 ggataacggc cccgccgcgc ccgccgcgca cgggaagtcg gaccgttcaa cctcctattg
    15661 cgtggcgggc acttcccgcc ttcggcatgg ttcctttttt tctgacctgt cgccagttca
    15721 tcccgccggc agtggtgttc agaacggtgg ggctcgcagc ggcggccggg accgtgccga
    15781 agctgccggt gggggcgctg ttaacctgtt cagcatgatc gcgaagagcg ccgggctgcg
    15841 gatacccggc ttagcgggcc ccagcggccc ccagcgtgcc ctcatcctcg cgagcttcgt
    15901 caaccgggtg ggcaacgggc tgttcaacac cgcttcggtg ctctacttca cgctggtggt
    15961 gcacctgccc gccgcgcggg tcggggtcgg cctcacggtc gccggcctgg tcgggctgct
    16021 ggccgggatc ccggccggga acctggccga ccggtacggg ccgcgcacgg tctggctgac
    16081 ggccttcgcg acgcaggccg cggcgatggc cgccttcgtc ttcatcgacg actggatcac
    16141 gttcacgctc atcgccaccc tggaccggct ggcggcgacg gcgggcggcg ccgcaggcgg
    16201 tgcgctcatc gcccgtgccg gcggggaacg cccggccgcc ttcatggcga agctccgcac
    16261 gttcgtcaac ctcggcgtgg tcctgggcac cgccggcgcc gccttcgccg tcgcggtcga
    16321 cacccgcgcg gcgtacaccg tgctcatcct cgccaacgcc gccagcttcg cctgcgcggg
    16381 cctgatcgcc ctgggcggcg tcccgaacta ccggcccctg ccccggccgg aggagcaccg
    16441 ccgctgggcc gtcctgtccg accggccgta cgtgtccttc gtcgcgctct acggcgcgat
    16501 gggcctgcag taccagaccg tctccctgct cctgccgatc tggctgtccg cccacaccga
    16561 cgcgccccgc tggaccgtgg cggcggtctc cgcggtcaac agcggggtct gcgtgctgct
    16621 ccagagcagg atcggctccc gggtggagac accgcgccag ggcggccggg cgttccgcct
    16681 cgcggggctg ctcttcctgg tcagctgccc cttgatggcc ctgaccgcgg acgttccggc
    16741 ctgggtcgcg ccggggctcg ccgtcctcgc cgtctgcgtg cacagtctcg gcgaggtgtg
    16801 ggagtcctcg ggcggctacg cgctcggctt cggtctcgcc cccgaccacg cccaggggca
    16861 gtaccagggc ttcttcggcg tcggcttcaa cgccggccag gccctggccc cggtggtcct
    16921 cacgacggcg gtcctcgggc tcggacacgc gggctggctg ctgctcggcg cgttcttcgc
    16981 ggccgtgggc gcggcgggcc cgccggtgac cgcatgggcg gagcgcaccc ggcgcccggg
    17041 cggcgacacg gcgggcacag cagacagccg acccgacgag gccccgcttc ccgagaccgc
    17101 gtagtcctcc gtgggccgcc ggctccacgc cgcagaaagt gagtgcagat gcaaccgacg
    17161 ttcgtactgg tccacggagc cttcgcgaac tccttctcct tcgcgccgct ccaggccgaa
    17221 ctcggcctcc tcggccaccg ctcggtcgcc gtcgacctgc cggggcacgg gttcgccgcg
    17281 acgtaccccc gggcctacca ggcgccgcag gacctcggcg ggctcgccac cgagcccggg
    17341 gccatcaagg gcgtgacgct cgccgacaac gccgcgcacc tcatcgggat actggagcgg
    17401 gccaagcgga acgggccggt cgtcctcgtc tcgcacagcc gcggcggcat cacggccacg
    17461 gtcgcggcca accggcggcc cgacctgatc gaccacatcg tctacgtctc ctcctggtgc
    17521 cccgtcaccc tcgacgtcgg cgcctactac gccgagcccg agatggccac ggtcgacgcc
    17581 gcggggctgg cctcggcgat ggtcgcgaac cccgccgagc tcgggctgct gcgctccaac
    17641 ttccgcaccg ccgaccccgg cgtcctcgcg gccttcaagg cggccttcct cgccgacggg
    17701 acggacgagg agttgttggt cttcctcaac accctccagc ccgacgagaa cctcgacgcc
    17761 ggcacctccg acgaccgggc gcaggccgac acctgggggc ggatccccag gtcgtacgtc
    17821 cggctgaccg aggacaccag cgtgccgctc accatgcagg accggatgat ccgcgagggc
    17881 gacgcgctga cgccgaagaa cccgtacgac gtccgcacgc tcaccagcag ccacctgaag
    17941 tggctggtcg acccggcacc ggcggcccgg gtcctgggtg agatcgccgc gctcctgccc
    18001 gccggatcgt gaccggagcc ggatgaggcc cgagggccgg ccgtccgccg cgtgaactcc
    18061 ggtgcggatg ggcgtgcggg cgcgagacga tcatctcccg gcaactcgca actcccctgg
    18121 gcgggatcac catctcgcgt cggtgccccg ccccgcccgc acgtgaggac ccccgcccgg
    18181 cagccggtcg ggggtcctca cgtgcgggcc gggtcagaca gcgccgaact cgccggcctg
    18241 gacgccggcg acgaacgact gccaggcggc gcgggggaag acgagtgcgg ggccctcggg
    18301 atccttggag tcgcggacgg ggacggcacc cgggaagctc gcggagacct ccacgcactg
    18361 accaccgttg tcggagtacg acgacttggc ccaggacgcg ccggacaggt cagagttcat
    18421 ggggctagct ccttccgagc cttgtggatc agtgccaggg aggccgcctt gggcagcgct
    18481 tccaccacca gttgatcgta ctctctctcc caggccacga ccgtttcgcg ggctcgttcg
    18541 agatgaccgc gagcatgtga ttcggcgtaa ccgacgaccg tgccatcagg gagatccagc
    18601 agggtcaccg gcattttgaa cggcaggttc tcccccagat ggaacggcgc cacctggagg
    18661 gtgacgttcg gccgggccgc caagtccgcg atgtgttcca actgttcgag catgacggcc
    18721 tgtccgccga tgggccggac caggcagctt tcgtccagca cggcatggat cagcggaggc
    18781 ttcttcctgt cgagcacgcg ctgacgcgca gccaggaact ccactcgctg ctccgccgcg
    18841 gactgcgtga tcgccccgcg ctcgacggcc gcgtacgcca gcgcctcggc atacccgggc
    18901 acctggaaca acccggtgac gatcgtcaac gcgaactcgc gcagacgccg gcaccgcgcc
    18961 tctgcgtccg cgaactccgg gaagccctcc agcaggctgg ccttcgagta ccggcaccag
    19021 agttcatgga aggtcccacc ggtttcgaac acctcatcgg ctttaaccgc gaagttagaa
    19081 gttacggcct tcttcgctct ttcgacgtac gacaccatcg cgttggagta acccatccgc
    19141 cgcccgagct cggtctgcga ccatcgcatg gcccggcgcg acctgcgaag ttccgcaccg
    19201 aagcggacga gtgctgatga gcttgcgtca gattcgctgt gcttcatggt cgttgccccc
    19261 atttaaccag acggaacgtt caaggttaga cccctggcca tcgtaggcca gtggggtcac
    19321 catggctaca ccgggtaaga gatccggaac ccagagctac catcggagcc aacgtgtcca
    19381 gctgcccccg catgcccgtc tacacgccca aggtcggcga aatcgtccgc gacctcgccc
    19441 accggaccgc cgacggggag cccgccgagg gcgtccacat ggaaaccctc gccggcctcg
    19501 cctacctccg gcccgtcggc ggcggctgcg agtggaccac caaacccgaa cacgtccagc
    19561 ggctcgacca ccctcacgac gtcaccgtcc agcaccccgg caggccccgc gcgcacgacg
    19621 tcgcgtgagc ccaaccctca ggctcctgac gacggtcctc gccgtgcccg ccctcagcag
    19681 cggcaccgcc gcactcgcct gccgactgat ccgcgacggg cccctggccc cgcgccttct
    19741 cgtcttcggc ctgatcctcg ccaccggcct gaccgtcggc ctccccacct gctactccct
    19801 cctgccggcc acacccgacc cctcccctcg gagcccgacg tgctgtaccc cctccccgac
    19861 atcctcacca acccgccccg ccgccggctc gaccaccagg cgctcgtcct caactccgac
    19921 ggcgccgtcc tcctcctcga aaccaccctc cgcaacggcc acaccctccc cggcggcagc
    19981 gccgaacgca acgaactccc ccacctcgcc gcccgccgcc acaccgagac ccagaccggc
    20041 ctcgtcctcc ccctgcgcac cctcctcgcc gccgaccaca ccgacgaaca actcctcccc
    20101 gaggctgttc acttcgtcta ctggggcggc cgcctcaccc gcgcccagga gaccaccctc
    20161 acccgccacc gaccgcccga ccacgtcctc ggcctgcact gggtccccga cacccgcctc
    20221 gccgacgtca tgaccaccgg acagcaccgc cgcgtcaccc aggccctcac cgccctcgcc
    20281 cgcggcgccc acctcccctt cctcctccgc ggcatccccg cccgctagtg cccatcaggc
    20341 aacgttcgcc ctgttgttca ccgctctgcg cggctacgcc ctgcgccgct acgccctcga
    20401 cggcaccgac cacgccggcc gcagggagca gggcagcgtg atccggcgga acagacgccg
    20461 acgaacggct acgcgacgtc gtggcccagg gcggacgtcg cctgatgccg cgccagtcag
    20521 ggcctgtccc aaagtccggc ccaggtggcc ctgtggcaag atcgcgggat gctacgactc
    20581 accgacttca ttatcgactg cccggacacg atgaagctgg cagccttcta ctccgaggtg
    20641 acggggctcc cggtcaagga gagcagtaac gagcactggg ccggcatcca gttcggcggg
    20701 atcgaactgg ccttcatcca ggtggaggac taccgcgccc cgcagtggcc cgacagcgag
    20761 caccccaagc agttccacct cgacttcgag gtcgacgaca tcgaggccga gcagcaccgc
    20821 gtccttgctc tcggcgcgac cctgcagcgg gactgcatcg aacccgacgg ctacggcttc
    20881 cgcgtctaca ccgaccccat tggccacccc ttctgcctct gccgcaacaa gggtgtcatc
    20941 tggaccgatc agggccccgt ctggcccaag cacgaccagt aggccgtgtt tcgaattgac
    21001 tgctcccccg cctgagggcg ggggattccg ccttcgtctg ggggatt
//
