LOCUS       NZ_CP026498            22811 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. CB01881 chromosome.
ACCESSION   NZ_CP026498
VERSION     NZ_CP026498.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB01881
  ORGANISM  Streptomyces sp. CB01881
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     A 3-hydroxy-3-methylglutaryl-CoA synthase gene based probe for the
            discovery of the acyltransferase-less polyketide synthases
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) Xiangya International Academy of
            Translational Medicine, Tongzipo, Changsha, Hunan 410000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002953255.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 02:39:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,978
            CDSs (total)                      :: 7,904
            Genes (coding)                    :: 7,565
            CDSs (with protein)               :: 7,565
            Genes (RNA)                       :: 74
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 124 of 339
            Pseudo Genes (incomplete)         :: 251 of 339
            Pseudo Genes (internal stop)      :: 10 of 339
            Pseudo Genes (multiple problems)  :: 45 of 339
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:44:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9399542
            Orig. end                         :: 9422353
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026498.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22811
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="34"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22811
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22811
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12811](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12811)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(361..996)
                     /locus_tag="C2142_RS30685"
                     /old_locus_tag="C2142_30715"
     CDS             complement(361..996)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014140126.1"
                     /locus_tag="C2142_RS30685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30715"
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="WP_241002877.1"
                     /transl_table=11
                     /translation="MRSETRPAPVPFVPEVTLHMAQDAIALWETTEAVRGEVGLAPPFW
                     AFAWAGGVGVARYVLDHPELVAGRTVLDLAAGSGLVGIAAALRGARSVRAAEIDAYAVA
                     AIDVNAEANGVRVDAAVEDLLDGDGAPAEVVLAGDVFYERAMAARFLPFLERARARGAV
                     VIVGDPGRAYLPRERFSALAAYDVPVVADLEDAALKTTTVWRLDPPQG"
     gene            1433..2614
                     /locus_tag="C2142_RS30690"
                     /old_locus_tag="C2142_30720"
     CDS             1433..2614
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524775.1"
                     /locus_tag="C2142_RS30690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30720"
                     /product="ROK family protein"
                     /protein_id="WP_148646089.1"
                     /transl_table=11
                     /translation="MADRLTGGDSSLLRRINAAVTLRALRAGHSVTLTQLVGDTGLSRP
                     TVEGVIEGLVETGLVAEVEQPQNGGQPGGAGRRGRPARWFRFRAEAGHILGVEIGVHDI
                     RVILADLTGEVVGSHFRTVEEGVDAEERLTAVRTVVAEVLRKAGVSRDNLWAVGVGTPG
                     IVDRDGTVQLGTAMPGWTGLDLGARLRRSFRCPVMIENDANLAAIAEHWQGAAVGADDV
                     VFVMAGLSPGAGSLINGKLHRGFGGAAGEIGALHLLGQEVTPERLLSTTGKPLNPLDEA
                     AVARVLKLAREGDEVAKVAMDRFLTRLVQGVAALVLAIDPQLVVVGGWAAGLDGVLEPL
                     RERLAQFTLRAPEVALAALGSEVVAMGALRVALDQVEEQLYAVDPPTGAGARA"
     gene            complement(2753..3550)
                     /locus_tag="C2142_RS30695"
                     /old_locus_tag="C2142_30725"
     CDS             complement(2753..3550)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144201.1"
                     /locus_tag="C2142_RS30695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30725"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_148646090.1"
                     /transl_table=11
                     /translation="MGTTGQLAAVPEPKYWHLRTVLLRAIDTEFSTGQVLPNERELSAR
                     FGVARATLRQALDQLELEGRLVRRRGIGTLIAAPRVGVPVNRHEEGWPGTARSQAWRTV
                     DCTTAPATARLAKALGIAEGATVHTVRRVRLVQGQNMATESLHVPAAALPHLPGFRAES
                     DRARSVLRQLERLEVDGESRAVELGVAEAEEAALLERPPGSPVLVMTTQYAAAGRLVAL
                     AVSTYRADTCKLTFGEAGVVEVTPVGAPVGAATGAAAEVRTAS"
     CDS             3569..3679
                     /gene="allorf_09403111_09403221"
                     /locus_tag="allorf_09403111_09403221"
                     /protein_id="allorf_09403111_09403221"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSAVLKGGRTRPAVRCCGRWESGLYPSFFIKGPCSK"
     CDS_motif       3569..3592
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSAVLKGG"
                     /locus_tag="allorf_09403111_09403221_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       3593..3679
                     /prepeptide="core"
                     /locus_tag="allorf_09403111_09403221_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.20"
                     /molecular_weight="3084.7"
                     /monoisotopic_mass="3082.6"
                     /core_sequence="RTRPAVRCCGRWESGLYPSFFIKGPCSK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSAVLKGG"
                     /leader_location="[3568:3592](+)"
                     /alternative_weights="3102.7"
     misc_feature    3649..3662
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.53"
                     /tool="antismash"
     misc_feature    complement(3651..3664)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.43"
                     /tool="antismash"
     misc_feature    complement(3700..3715)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.06"
                     /tool="antismash"
     misc_feature    3745..3760
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.89"
                     /tool="antismash"
     misc_feature    3745..3765
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            3870..4679
                     /locus_tag="C2142_RS30700"
                     /old_locus_tag="C2142_30730"
     CDS             3870..4679
                     /EC_number="3.1.11.2"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968504.1"
                     /locus_tag="C2142_RS30700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30730"
                     /product="exodeoxyribonuclease III"
                     /protein_id="WP_148646091.1"
                     /transl_table=11
                     /translation="MIVVTSVNVNGIRAAAKKGFIEWLAATEADVICLQEVRSEPGQLP
                     VELRDLDGWHAVWAPSVAKGRAGVALLSRQEPERTVVGFQSEEFDNSGRYVEIDLPGLT
                     VASLYLPSGEVGTERQEEKERFMAEFLVHLGRLRTRAAAEGREVVVCGDWNIAHRPEDL
                     KNWKANQKSAGFLPEERAWLTRVYEEAGYVDVVRRLHPDRTGPYSWWSYRGRAFDNDSG
                     WRIDLQVATPGLAAKAVEAYVERAETHAERWSDHAPVTVAYDHDQLL"
     misc_feature    complement(3878..3893)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     gene            complement(4777..7299)
                     /locus_tag="C2142_RS30705"
                     /old_locus_tag="C2142_30735"
     CDS             complement(4777..7299)
                     /EC_number="3.4.24.3"
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139076.1"
                     /locus_tag="C2142_RS30705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30735"
                     /product="collagenase"
                     /protein_id="WP_241002878.1"
                     /transl_table=11
                     /translation="MLLRTRLSVLAAGVVACCATATAVLPAQAFAAPPVVTAGSAPTTT
                     TASAGPVGPAAPTAPTTTTGSEEPGEPAAPLSPALIGATRLLEEPADAAAPAQFKSLAV
                     QSCTPADFAAHTGAELVAFIKSSTPECINSLYQSAGADPSIFNQARMLSVAAALKDVAA
                     NYPGDNTTGIAQLVKYLQVGYYIQFYYPAAAGAYTPALTDAVTTALDTLFAGTRWRDVS
                     ENNGRILKEVVWLTDSANVQAHYLGVYKRILDEYDNTYNQFPQMRSAVNSVLFYPLWEG
                     YRNKDFVQALAADPSLINSLADFAMNHRDLLSGPHSVLDTNAGNDLAKFAGTSPAAEAV
                     AKPLVKKVLDSAPLLSPFGSLYLYTARQAEYFNYSQCSYYGICDLRNKLTSVILPNQLV
                     CDNRILQAQSLSAAELATVCESLRKQDALFHSVSKDSGAIPNQYAKTVTFGIFANKADY
                     TTYSWAIYGNSTDNGGQTVMDATDPNKRAVTVMYQKAWNVNDPARVWNLNHEYTHYLDG
                     IYNLKGNYDTQSSVPNKWWVEGLAEYVSYSHRGATDVDAMNQAAKHTYKLSTLFQNTYA
                     NSDSTRIYPWGYLSVRYMLERHPADVQAMLERFRVGDYPGGYAVYNNLGTSYDADFDAW
                     LDACVAGGCYATGPTSLFDTTANGATVSLNERSVQTGPGRITGWHWDFGDGTFSDERSP
                     SHTYGAPGPYTIALTTTDDTGRSGTTQGAVTTTALGLPACPEQRADAMDRNCARTGRSA
                     TVGNTDYLYVYLPAGTATLKVNTFGGTGTAYLYYNADTWASPKAYTAASTAAGTTQSIT
                     VTNPTAGYRYFGLYAATDFTGVTVTTQF"
     misc_feature    complement(7383..7397)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.35"
                     /tool="antismash"
     misc_feature    7392..7402
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     misc_feature    7392..7412
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.27"
                     /tool="antismash"
     misc_feature    complement(7403..7419)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.7"
                     /tool="antismash"
     CDS             complement(7406..7618)
                     /gene="allorf_09406948_09407160"
                     /locus_tag="allorf_09406948_09407160"
                     /protein_id="allorf_09406948_09407160"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MHARPGSPGRAFRIGAQIGQSVRPVGLVRPSGSWPDVPSAPIRRS
                     AQAGNVAGQPLGGCEPRDGRNSHAI"
     CDS_motif       complement(7472..7618)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MHARPGSPGRAFRIGAQIGQSVRPVGLVRPSGSWPDVPSAPIRRSAQAG"
                     /locus_tag="allorf_09406948_09407160_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7406..7471)
                     /prepeptide="core"
                     /locus_tag="allorf_09406948_09407160_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.90"
                     /molecular_weight="2084.3"
                     /monoisotopic_mass="2083.0"
                     /core_sequence="NVAGQPLGGCEPRDGRNSHAI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MHARPGSPGRAFRIGAQIGQSVRPVGLVRPSGSWPDVPSAP
                     IRRSAQAG"
                     /leader_location="[7471:7618](-)"
     misc_feature    7416..7430
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            complement(7914..8465)
                     /locus_tag="C2142_RS30710"
                     /old_locus_tag="C2142_30740"
     CDS             complement(7914..8465)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151160.1"
                     /locus_tag="C2142_RS30710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30740"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_148646093.1"
                     /transl_table=11
                     /translation="MDTTDVLLHPVRLRVVHALSGGRVLTTAQLCERMPEVPKVTMYRH
                     VALLAEAGFLEVAGEQRVRGAVERHYRLRQDRPVVDVDAAAAMTPEDHRRGFATAMAVL
                     IAEFNAYLDRDGADPVADAVSYRQGTLWLSPDELAEMTAELLAVLGPRLANRPAPGRAP
                     YLLSPIRFPLGPPSPDEERP"
     gene            8528..9394
                     /locus_tag="C2142_RS30715"
                     /old_locus_tag="C2142_30745"
     CDS             8528..9394
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (26-161). E-value:
                     1.8e-15. Score: 49.2. Matches aSDomain:
                     nrpspksdomains_C2142_RS30715_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="C2142_RS30715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30745"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_162002597.1"
                     /sec_met_domain="PF00561 (E-value: 4.6e-11, bitscore: 41.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.1e-18, bitscore:
                     65.6, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 1.1e-07, bitscore:
                     31.2, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQAAGRAVRVNGRTVHVEESGSGADWVVFEAGGGMGRTCWDPVL
                     PWLTDRTRMVAYDRAGFGRSGRTATQLSIEDLAADLVALVEAVVPDRFVLVAHSMGGLV
                     ARRAVEGLGRRLRGMLLLDPAAEGAPVYDAFDRTAAKVDRSLAVTQALFRSRRLARLAS
                     GNIRRLFPTDTYETMLAEDFVPSGTAQTRKEIKAVAAAIPRFRADPPAPPTCRTILLSA
                     SRPQAGRSRHHADLAAHQRRWTESLPDGRFETVDSGHFIQADQPKIVADRVKHLLDHAG
                     RAGAPST"
     aSDomain        8606..9010
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS30715_Abhydrolase_1.1"
                     /evalue="1.80E-15"
                     /label="C2142_RS30715_Abhydrolase_1.1"
                     /locus_tag="C2142_RS30715"
                     /protein_end="161"
                     /protein_start="26"
                     /score="49.2"
                     /tool="antismash"
                     /translation="WVVFEAGGGMGRTCWDPVLPWLTDRTRMVAYDRAGFGRSGRTATQ
                     LSIEDLAADLVALVEAVVPDRFVLVAHSMGGLVARRAVEGLGRRLRGMLLLDPAAEGAP
                     VYDAFDRTAAKVDRSLAVTQALFRSRRLARL"
     gene            9560..9736
                     /locus_tag="C2142_RS30720"
     CDS             9560..9736
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS30720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_153882833.1"
                     /transl_table=11
                     /translation="MENASFRWRIDLIVTTPGLADRAVEAYVERAATHAERWSDHAPVS
                     TVFELGQLADSPR"
     gene            complement(10001..12811)
                     /locus_tag="C2142_RS30725"
                     /old_locus_tag="C2142_30750"
     CDS             complement(10001..12811)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="C2142_RS30725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30750"
                     /product="type 2 lantipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_241003301.1"
                     /sec_met_domain="DUF4135 (E-value: 3.3e-97, bitscore:
                     324.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.1e-10, bitscore:
                     38.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQTLRLAESAPGGRIRSLPGTGPEGRLLHPLRPFLLTASRHFAA
                     VNPAAADRRVVWAGARHHLAGGLVRLAGRTLVQELGHARRAGTLTGQDGRERFDAFLCE
                     VAAGPALGAVLHRHPVLARLLAERCTRTVAAATELLERLHADREQLTAALLDGEPGRLT
                     RVRFGLGDPHAAGRSVAVLEFDGGQRLVYKPRPLGLHARWNELLAWFGGRQPQLAARAV
                     RLLPRAGYGWAEYVAPRPCRSQAEVGRFYERLGAQLALLHVVNAVDIHAENLIAARDQP
                     VVVDVETLFHPCWAPVTDGGADPAARALAASVQRTMVLPNPWFGGGGSLDLSALGGQAD
                     QWTPDPMPGWADAGTDLMRLVRRPARWPGADNRPMLAGRPADPADQLDRLLCGFRAGYR
                     AIAAHSHELLGEQGMLSRFAGEAMRLVARPSQSYATLLAEATEPELLRDHSGRERAFAA
                     LHDETGYPHLHVLAPHELTDLLAGDVPFFTTTPAARTLRTWDGRELPFLLDESGLTAAA
                     GTIRGMSEGDLDRQAWLIRASLAAGRRSPGRHAPGRPAAESEDAYDGDPGAQALELARG
                     IGEDLLSRVCRGEGRVNWLGLQEAWPGQWAVLPMGMALGDGYTGPALFLAELGRLTGAV
                     RYQEAAAQAVRVLPQLLRLLAEHPELARAVGPGGFSGLGGISYATARLATLLDSPELSA
                     ALPAGLAALHTAAVDPAAPMDIADGLAGALLAAEAVHAQTRLPAAAELAHTVRTLAGHR
                     PRPERPGFLHGHEGVAWALRERAAVDLADSDGPGRCPDWVGRALRACKADQHLALLADR
                     VPMPGHSLRHGELGLLEPLVELMPTDAGHRRTAARLVRSVEQQGARCGTPSEVPTPGLL
                     TGLAGIGYGLLRLGFGPRIPSVLLLRPAAGPGPVEREGGHHHDGRRTARQCGQRAAGDR
                     RASHGG"
     misc_feature    12927..12937
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(13001..15964)
                     /locus_tag="C2142_RS30730"
                     /old_locus_tag="C2142_30755"
     CDS             complement(13001..15964)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="C2142_RS30730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30755"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_148646097.1"
                     /transl_table=11
                     /translation="MTEPRVDRFSGLVGREDELVLLDRVLQDARQSRGGTVCVTGEPGI
                     GKTRLAGEAITLAREAGMTVLKGRCIATGPAVPYRSLTEALLSLARAGGAPPTDALGPY
                     LPVLGRLVPEWAIGDACDRSPIVLAEAVVRLAAACGRERGCLLVIDDLHDADPETLAVL
                     EYLAANLALLPVAVVATLRDTPGAAHSLADTLAQRGEAGLLRLGRLGAAQVHALTANCL
                     GCPPDELPVAVSDRVLADSSGIPFTAAELIRGMRAEGRLVRTEGRWRLVGTSRAAIPFT
                     LVRAVEQRAERLGPQTLRLLSAAAVLGRSFPLSVARRCAAPDDHEPAVSLRSAVVDGLL
                     VPDDERGPDWYAFEHPLTQEALLDRLTPADRAELAARAVAAMNELDPSLPGTWCLVAAR
                     LHGQAGDRRTAAVRYLEVARRALAGHGPGTAIAALHEARSALGPVDGSDIHLPDDAVPA
                     GVRRELLETLLLALADDGRLDRATEVAQQLRRADVEADPGRRVELHVRLAWAAQVAGQW
                     DVGLEQVRAARELLPEGAGARDTAGIDVVEAYLTVSTAEQGRIGRSEQLARRAIEGAEQ
                     RGDHALACQAWYAMGFATRGRSLAESDRCFRRTLRMAAESRQVSWHNHGLIGLGSNAWL
                     AEADLDGLHHAHQEAMRTGCVSLAHNVGAMLALDAVLRADFDRAAALLDGSRAETERLQ
                     LHSVSRYALMVGAVAAAHRARRLQLRAALARFRTSGGNESREAPLVLGLAELFCALLEE
                     DHEQAAELAARLAAAAPPDEENYFHLAGSHGLVLLLSVLAGRADWAEVERITASQAGRM
                     RWNRQFVGLARAVLYGREGRPAEAVAACRAAQADAVIFPTARHLGLRLVADAAVTDGWG
                     AVRDWLTEAETYFHHSGADAVAAACRSRLRSLGAPVGQRRTGTDRIPAELVALGVTLRE
                     YDVFCLLVERVGNKAVAARLQISPRTVEKHIASLIGKTNSATRAQLCDFVADFLAAR"
     misc_feature    15984..15997
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            complement(16006..16572)
                     /locus_tag="C2142_RS30735"
                     /old_locus_tag="C2142_30760"
     CDS             complement(16006..16572)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014494.4"
                     /locus_tag="C2142_RS30735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30760"
                     /product="flavoprotein"
                     /protein_id="WP_206671055.1"
                     /sec_met_domain="Flavoprotein (E-value: 3.9e-19, bitscore:
                     67.7, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNDALSVIACGSIAAKDLPNYLVFLRQEIDLPLRVLLTASAARF
                     VHPQVLAWHADEVYVADDPTLNPTEFAHRSLGLVVLPATANTLAAAALGLAATPAQTVL
                     LAHERPALFFPNMNGSMWRKPATRRHVSTLRADGHTVVEPTEREMFLLWQKENGVGPAM
                     PGPDEAAETVVKWLEDALNGDDESA"
     CDS             16671..16844
                     /gene="allorf_09416213_09416386"
                     /locus_tag="allorf_09416213_09416386"
                     /protein_id="allorf_09416213_09416386"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSAHRAPCHRRSRRSATRAGGANPPLHQGSRTMKKIAVRKTGSIK
                     LTSPASYVLVVC"
     CDS_motif       16671..16733
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSAHRAPCHRRSRRSATRAGG"
                     /locus_tag="allorf_09416213_09416386_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       16734..16844
                     /prepeptide="core"
                     /locus_tag="allorf_09416213_09416386_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.90"
                     /molecular_weight="3680.4"
                     /monoisotopic_mass="3678.1"
                     /core_sequence="ANPPLHQGSRTMKKIAVRKTGSIKLTSPASYVLVVC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSAHRAPCHRRSRRSATRAGG"
                     /leader_location="[16670:16733](+)"
                     /alternative_weights="3698.5"
                     /alternative_weights="3716.5"
                     /alternative_weights="3734.5"
                     /alternative_weights="3752.5"
                     /alternative_weights="3770.5"
                     /alternative_weights="3788.6"
     gene            16963..18108
                     /locus_tag="C2142_RS30740"
                     /old_locus_tag="C2142_30765"
     CDS             16963..18108
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS30740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_30765"
                     /product="hypothetical protein"
                     /protein_id="WP_148646098.1"
                     /transl_table=11
                     /translation="MATTDLAFHPLTFVTERDGTLVGRPDTGSFALLPEDGAALLRRLA
                     DGMPLAEAAAWYDAAYGEPVDLADFIETMRDLGFVHEPGAAAEPVPVRLQAWGRAMFSP
                     LGWSCYALITALAIAAMIYEPRLQPHTRNLFFVPSLVAVEVTLAALQMPLMLWHEGWHV
                     LAGRRLGLPTGLGIGRRLYFVVFETRLDALFGVRPAQRYLPFLAGMLGEVVLFGALTLA
                     AAVDLATGPSWAGRFALAVAYLILPRLAWQFLIFLRTDLYYVLATALGCADLHEVGSAY
                     LRHRLGRGGWAEDRWTARERALAPWYALLTAIGTAFLLVAAVFTVVLPAVTFARRLADG
                     IAQSSLSDSRLWDAAVALLVIVVQVVVLPLLVGRRQRRAAA"
     gene            18139..20274
                     /locus_tag="C2142_RS30745"
                     /old_locus_tag="C2142_30770"
     CDS             18139..20274
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1272: TPR
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024824.4"
                     /locus_tag="C2142_RS30745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30770"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_148646099.1"
                     /transl_table=11
                     /translation="MTSHTWRLQPEGTAHDDRYDARADCHRRLRGPYTGLGTLLRSLVP
                     DAHRARPELVAHHAVEILSAAPELKDLIGAGPQTLTSLAVPNERTRLYPAKRTRRLAHG
                     IIEFLHGHARERGHALALRFDRVDEADHTDQEFLAILLRRALPDLVMVTVHTGGADLIP
                     ELTTALAAHATHTIAQHPDEHENLTDHQKLALAYVESDGTSHDPAEQAAYRRVDAAERA
                     RLHDQRAAELRRSGDWSLCLGAIPYHLEHGSDREAAADAFLEAAEYLVSMGFYHSLLDV
                     AGRGTALMDPAEEPRKYWMLGTKVTTALAILGRPEEAERRYIELRAMFDQPMLHIFSGY
                     ALAMLYTRYYPAEHKDHQLAKAHLHNVLAMASLLPDHDQRVFQSVFNRNGLALVELQLG
                     NPTEALRLVSTGLADIDRELPAEKHRLHRSVLVHNRGRVYTALGRLEEALADIDTVIEL
                     DPNYPDYYFDRADVRRRMGDLPGALADYSESITFAAPFWEMHYNRADLRLELGDLAGAI
                     ADLGYVLELEPDELDARINLASLLREQGDAAGSLTQVEEGLRHHPGDARLLCARGLLAL
                     DAGADQEALRDFDLALTAEPDLVSALANRAALVLETGDHRTAVADLTRALAIEADDPDL
                     LYNRGYVHQSAGDWESARRDYTAALLLPGADRADLLRQRAECHLALGDPTAHQADLAAA
                     ESAASSPNAVADPVRVS"
     gene            20298..20822
                     /locus_tag="C2142_RS30750"
                     /old_locus_tag="C2142_30775"
     CDS             20298..20822
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013756.4"
                     /locus_tag="C2142_RS30750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30775"
                     /product="flavin reductase family protein"
                     /protein_id="WP_206671056.1"
                     /transl_table=11
                     /translation="MTGPVTPRPQPPAVSGPALRSVMRRWATGVALVTATAQGRPTGCT
                     ASSFTSVSLSPPLVLVSLYRSSRTLAAITSQGAFGINLLGRHHQDLADRFATAPAEQRF
                     TGVGHRLVRDVPVIDEAMAALVCRVERTVATADHLLVLGQPMWCDQNGAADPLVHFGSH
                     YQCLAVGSARA"
     gene            complement(21053..21277)
                     /locus_tag="C2142_RS40575"
     CDS             complement(21053..21277)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF040065.3"
                     /locus_tag="C2142_RS40575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_241002879.1"
                     /transl_table=11
                     /translation="MRVGPGRAADQGQAARLPGCGQNSRSYATVTGASTDGIELQDRAF
                     VAAIREGREPDSSIARVMSCYRTPAGLET"
     CDS_motif       complement(21179..21277)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRVGPGRAADQGQAARLPGCGQNSRSYATVTGA"
                     /locus_tag="C2142_RS40575_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21053..21178)
                     /prepeptide="core"
                     /locus_tag="C2142_RS40575_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.00"
                     /molecular_weight="4297.8"
                     /monoisotopic_mass="4295.2"
                     /core_sequence="STDGIELQDRAFVAAIREGREPDSSIARVMSCYRTPAGLET"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRVGPGRAADQGQAARLPGCGQNSRSYATVTGA"
                     /leader_location="[21178:21277](-)"
                     /alternative_weights="4315.8"
                     /alternative_weights="4333.8"
                     /alternative_weights="4351.8"
                     /alternative_weights="4369.9"
                     /alternative_weights="4387.9"
                     /alternative_weights="4405.9"
     gene            complement(21346..22710)
                     /locus_tag="C2142_RS30760"
                     /old_locus_tag="C2142_30785"
     CDS             complement(21346..22710)
                     /EC_number="4.1.1.15"
                     /GO_function="GO:0004351 - glutamate decarboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006540 - glutamate decarboxylation to
                     succinate [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (91-378). E-value: 5e-10.
                     Score: 30.7. Matches aSDomain:
                     nrpspksdomains_C2142_RS30760_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180: Decarboxylase, pyridoxal-dependent"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010985032.1"
                     /locus_tag="C2142_RS30760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30785"
                     /product="glutamate decarboxylase"
                     /protein_id="WP_148646100.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-05, bitscore:
                     22.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKSDVGDLFGNRFLTVPAPSETFPEEGMTATDAMRLVDEDLVME
                     GDPQRNLATFVTTWMEPEAQRIIAENLHRNFIDHAEYPISAEIEQRCVRMLADLFNAPG
                     RTTGCRTQGSSEAIMLGALSLKWKWRERRKAANLSADRPNLVFGGDVHVVWEKFCRYFD
                     VEPRIVPLAEGKYTIGPEDVEPHLDENTIGVVAVVGTTFTGHKDDVVGIDKLLREIRKK
                     RDLDIPIHVDGASGGFVWPFLYPDSKWDFRLEQVRSINVSGHKYGLVYPGIGWLVFREE
                     SDLAKDLVFYENYLGKTDATFTLNFSTGASMVLAQYYNFVRLGRQGYTYVMETMQTNAH
                     ALAENLRDSGRFEVIGSDLEQLPLVAFRLAGKHSYDESDIAWQLSAERGWMVPAYTLPP
                     KAERVKILRALVKETLSRGQIDRLTQDIADACATLDHKGATTEVERAQVKRGSGY"
     aSDomain        complement(21577..22437)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS30760_Aminotran_5.1"
                     /evalue="5.00E-10"
                     /label="C2142_RS30760_Aminotran_5.1"
                     /locus_tag="C2142_RS30760"
                     /protein_end="378"
                     /protein_start="91"
                     /score="30.7"
                     /tool="antismash"
                     /translation="CVRMLADLFNAPGRTTGCRTQGSSEAIMLGALSLKWKWRERRKAA
                     NLSADRPNLVFGGDVHVVWEKFCRYFDVEPRIVPLAEGKYTIGPEDVEPHLDENTIGVV
                     AVVGTTFTGHKDDVVGIDKLLREIRKKRDLDIPIHVDGASGGFVWPFLYPDSKWDFRLE
                     QVRSINVSGHKYGLVYPGIGWLVFREESDLAKDLVFYENYLGKTDATFTLNFSTGASMV
                     LAQYYNFVRLGRQGYTYVMETMQTNAHALAENLRDSGRFEVIGSDLEQLPLVAFRLAGK
                     HSYDES"
     misc_feature    22668..22679
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.07"
                     /tool="antismash"
ORIGIN
        1 gatcacggtg ccgacgacgg tcccggtgtc cgcggccggc gtggcgacga tcaggcactc
       61 cgggtcgcgc tccagcagag cggccacacc gtcggcgtcg tccgtgatgc tggtcccctt
      121 ggccgcgcgg gcccagaggg cgagcaccgc gggtatctcg tcgggggtgg cggcacgcag
      181 cacgacgtca cccgcgccgg tggcggtcac gtcagaggtg acctcgtcgg tcaggtcgcc
      241 ggcggtcagg tcgccggcgg tcaggtcgcc ggagggctcg tcggtcaggt cgtcggtcat
      301 gtcggtgtgt ctaccaggcc gttcggcccg tccgctggta tttccggact ccggacgggc
      361 tcagccctgc ggcgggtcga gccgccagac cgtggtggtc ttgagcgccg cgtcctccag
      421 gtccgcgacc accgggacgt cgtacgcggc cagcgcgctg aaccgctcgc gcggcaggta
      481 ggcccggccc gggtcgccga cgatcaccac cgcgccacgg gcccgcgccc gctccaggaa
      541 ggggaggaag cgggcggcca tcgcccgctc gtagaagacg tcgccggcga gcaccacctc
      601 ggccggtgcg ccgtccccgt ccagcaggtc ctccaccgcg gcgtcgaccc ggacgccgtt
      661 cgcctcggcg ttgacgtcga tggccgccac cgcgtaggcg tcgatctcgg cggcccgtac
      721 cgaccgcgcg ccgcgcagcg ccgccgcgat gcccaccagt ccggacccgg ccgccaggtc
      781 gagcaccgtc cgccccgcga ccagttccgg gtggtcgagc acgtaccgcg cgacgccgac
      841 cccgccggcc caggcaaacg cccagaacgg cggcgccagg cccacctcgc cgcgcacagc
      901 ctccgtggtc tcccacagcg cgatggcgtc ctgcgccatg tggagggtga cctcggggac
      961 gaacggcacc ggggccggcc gggtctcact ccgcacaaag ctccggtccg acagcacagt
     1021 tgcacccgga tgaacgtcgc gcgtctcgtt cagcatgtcc gcagcataga ggctccgcgg
     1081 gggtatcccg accagcccgc gccgcgccgc gggcaggggc gggaggggga cgagggtgtg
     1141 ccggtggtgc cgtggaaggg aggagcacgc acggcgaccc ggtgcgtacc atttcgatac
     1201 cgaagccttg gtgagctgcg aagatgctcg cccgccgggc ccgggcccgg gtagcatccg
     1261 gcacgtgccc tccgggctgg cgcaggcggc tcagcgctgc cgtgcccgcg gtccgggcgg
     1321 cggactcccg cgggacaccc ggcggtcggc attcggtggt cggcattcgg tggtcaccgc
     1381 gcactcggca ccgcgcgcca gggctgtcgc gcgaacggcg aagggcagcg tcttggcgga
     1441 tcggctcacc ggaggagact cctcgctgct gcggcggatc aacgcggcgg tcacgcttcg
     1501 ggcgctgcgg gccggccact cggtaaccct cactcaactg gtcggggaca ccggactgtc
     1561 ccggcccacg gtggagggcg tgatcgaggg cctggtcgag accggcctgg tcgccgaggt
     1621 ggagcagccg cagaacggcg gccagcccgg cggcgcgggc cgccgggggc gtccggcccg
     1681 ctggttccgg ttccgcgccg aggccgggca catcctgggc gtcgagatcg gcgtgcacga
     1741 catccgggtc atcctcgccg acctcaccgg cgaggtggtg ggcagtcact tccggaccgt
     1801 cgaggagggc gtcgacgccg aggagcggct gacggccgta cgaaccgtcg tcgccgaggt
     1861 cctgcgcaag gccggcgtct cccgggacaa cctctgggcg gtcggcgtcg gcacccccgg
     1921 catcgtcgac cgcgacggca ccgtgcagct cggcaccgcc atgcccggct ggaccggcct
     1981 cgacctgggc gcccggctgc ggcgctcgtt ccgctgcccc gtgatgatcg agaacgacgc
     2041 caacctggcc gccatcgccg agcactggca gggcgcggcg gtcggcgcgg acgacgtggt
     2101 cttcgtgatg gcgggcctca gccccggcgc cggctcgctg atcaacggca agctgcaccg
     2161 cgggttcggc ggcgcggccg gcgagatcgg cgccctccac ctgctcggcc aggaggtcac
     2221 ccccgagcgc ctgctctcca ccaccggcaa gccgctcaac ccgctggacg aggccgccgt
     2281 cgcccgggtg ctgaagctgg cccgtgaggg cgacgaggtg gcgaaggtgg cgatggaccg
     2341 cttcctgacc cgcctggtgc agggcgtcgc cgccctggtc ctggcgatag acccgcagct
     2401 ggtcgtggtc ggtggctggg ccgccggcct cgacggcgtc ctggagccgc tgcgcgagcg
     2461 cctcgcccag ttcaccctgc gcgcccccga ggtggcgctg gccgcgctcg gctcggaggt
     2521 cgtcgcgatg ggcgcactgc gggtggcgct ggaccaggtc gaggagcagc tctacgcggt
     2581 cgacccgccc acgggcgcgg gcgcccgggc ctgaccctgc ctgggccggc ggtctcccgt
     2641 gacggcctct cccgacggcg gccaccaacg accaccaccg ccaccaacgg cccaggcccg
     2701 gacgcctgtg ggcgtgtccg ggcctgggcc tgagggtatt tcggcaggtg gttcaggagg
     2761 cggtgcgcac ctcggcggcg gcaccggtcg cggcgccgac gggggcgccg acaggggtga
     2821 cctcgacgac gccggcctcg ccgaaggtga gcttgcaggt gtcggcgcgg taggtggaga
     2881 cggcgagggc gaccaggcgg ccggcggcgg cgtactgggt ggtcatcacc aggacgggcg
     2941 agccgggcgg gcgctccagc agggcggcct cctcggcctc ggcgacgccc agctcgacgg
     3001 cgcgggactc accgtcgacc tccaggcgct ccagctggcg cagcaccgag cgggcacggt
     3061 cgctctcggc gcggaagccg ggcaggtgcg gcagggcggc ggcgggcacg tgcagcgact
     3121 cggtggccat gttctggccc tggaccagcc gcacccggcg gacggtgtgc acggtggcgc
     3181 cctcggcgat gccgagcgcc ttggcgagcc gcgcggtggc gggggcggtg gtgcagtcga
     3241 cggtgcgcca ggcctggctg cgggcggtgc cgggccagcc ctcctcgtgc cggttgaccg
     3301 ggacgccgac ccggggggcg gcgatcaggg tgccgatgcc gcggcggcgg accagccggc
     3361 cctccagctc cagctggtcg agcgcctggc gcagggtggc ccgggcgacc ccgaagcggg
     3421 cggagagctc gcgctcgttg ggcaggacct ggccggtgga gaactccgtg tcgatcgcgc
     3481 ggagcagcac cgtgcgcagg tgccagtact tcggttccgg taccgccgcg agctgtcctg
     3541 tcgttcccac cgtggcctcc accctgtttt gtccgccgtg ctgaaaggag ggcggacccg
     3601 gcccgctgtc cgctgttgcg gcaggtggga gagcgggctt tatccgtcct tctttattaa
     3661 aggtccttgc agtaagtgac cctaggggct gcgtcgggag atggtcaaga ccaatgacgg
     3721 cggttggtgc ggttgtcccg cgggttcacg tcgcgttcac gacactccga tatccggaca
     3781 cccggccgcc gacccttggt accccggccc ttcccccgcg ctcgacgcgc cgccgccgcg
     3841 ccggccgggg ggctcgatag gcttcccggg tgattgtggt gacgagtgtc aatgtgaacg
     3901 ggatccgggc ggccgccaag aagggcttca tcgagtggct ggcggccacc gaggcggacg
     3961 tgatctgcct gcaggaggtc cgctccgagc ccgggcagct gcccgtggag ctgcgcgacc
     4021 tggacggctg gcacgcggtc tgggcgccgt cggtcgccaa gggccgtgcg ggtgtcgccc
     4081 tgctgtcccg gcaggagccg gagcgcacgg tggtcggatt ccagtccgag gaattcgaca
     4141 attcgggcag gtatgtggaa atcgaccttc ccgggctgac cgtggccagc ctctacctcc
     4201 cctccggcga agtcggcacc gaacgccagg aggagaagga acgcttcatg gcggaattcc
     4261 tcgtccacct cggcaggctc cgcacccggg ccgccgcgga gggccgcgag gtcgtcgtct
     4321 gcggcgactg gaacatcgcc caccgcccgg aggacctcaa gaactggaag gccaaccaga
     4381 agtcggccgg cttcctcccc gaggaacgtg cctggctcac ccgcgtctac gaggaggccg
     4441 gctacgtcga cgtggtccgc cgcctccacc ccgaccgcac cggcccctac tcctggtggt
     4501 cctaccgcgg ccgggccttc gacaacgact cgggctggcg catcgacctc caggtcgcca
     4561 ccccgggcct cgccgccaag gccgtcgagg cgtacgtcga acgcgccgag acccacgccg
     4621 agcgctggtc cgaccacgct ccggtgaccg tggcgtacga ccacgaccaa ctcctctagc
     4681 acttaccgaa gttcgggcaa ttgcagtgcc ccgcccgcgc acgcgaacgc ccggccggga
     4741 gagcccggcc gggcgccagt cgcggtgctc cgtggatcag aactgggtgg tgacggtgac
     4801 gccggtgaag tcggtggcgg cgtacaggcc gaaatagcgg tagcccgccg tagggttggt
     4861 gacggtgatg gactgggtgg tgcctgcggc cgtggaggcg gcggtgtagg ccttcggcga
     4921 cgcccaggtg tccgcgttgt agtacaggta cgcggtgccg gtgccgccga aggtgttgac
     4981 cttcagcgtg gcggtcccgg ccggcaggta gacgtacagg tagtcggtgt tgccgacggt
     5041 cgccgagcgg ccggtccggg cgcagttgcg gtccatcgcg tcggcgcgct gctcggggca
     5101 ggccggcagg ccgagggcgg tcgtggtgac cgcgccctgt gtggtgccgc tccggccggt
     5161 gtcatcggtg gtggtcagcg cgatggtgta cgggccgggc gcgccgtagg tgtggctcgg
     5221 gctgcgctcg tccgagaagg tgccgtcgcc gaagtcccag tgccagccgg tgatccggcc
     5281 cgggccggtc tgcacggagc gctcgttcag gctgacggtc gcgccgttcg ccgtggtgtc
     5341 gaacagcgag gtcggaccgg tcgcgtagca gccgccggcg acgcaggcgt cgagccaggc
     5401 gtcgaagtcg gcgtcgtacg aggtgccgag gttgttgtag accgcgtagc caccggggta
     5461 gtcaccgacg cggaagcgct ccagcatcgc ctggacgtcg gccgggtgcc tctccagcat
     5521 gtaccggacg gacaggtagc cccacgggta gatgcgggtc gagtccgagt tggcgtaggt
     5581 gttctggaag agcgtgctga gcttgtaggt gtgcttggcc gcctggttca tcgcgtcgac
     5641 gtcggtggcg ccgcggtggc tgtacgagac gtactcggcg aggccctcga cccaccactt
     5701 gttcgggacg gacgactggg tgtcgtagtt gcccttcagg ttgtagatgc cgtcgaggta
     5761 gtgggtgtac tcgtggttga ggttccacac ccgggcgggg tcgttgacgt tccaggcctt
     5821 ctggtacatc acggtcacgg cccgcttgtt cgggtcggtc gcgtccatga cggtctggcc
     5881 gccgttgtcg gtgctgttgc cgtagatcgc ccacgagtag gtggtgtagt cggccttgtt
     5941 ggcgaagatc ccgaaggtga cggtcttggc gtactggttc gggatggccc cgctgtcctt
     6001 ggacacgctg tggaagagcg cgtcctgctt gcgcaggctc tcgcagacag tggccagttc
     6061 ggcggccgac agggactggg cctggaggat gcggttgtcg cagaccagtt ggttcggcag
     6121 gatcaccgag gtgagcttgt tgcgcaggtc gcagatgccg tagtacgagc actggctgta
     6181 gttgaagtac tcggcctggc gggccgtgta caggtacagc gacccgaagg gcgagagcag
     6241 cggcgcggag tccagcacct tcttgaccag cggcttggcc acggcctcgg cggcggggct
     6301 ggtcccggcg aacttggcca ggtcgttgcc cgcattggtg tcgaggacgg agtggggccc
     6361 gctgagcagg tcccggtggt tcatcgcgaa gtcggcgagc gagttgatga ggctcgggtc
     6421 ggccgcgagc gcttggacga agtccttgtt ccggtagcct tcccagagcg ggtagaacag
     6481 cacggagttg accgcgctgc gcatctgcgg gaactgattg tacgtgttgt cgtactcgtc
     6541 caggatccgc ttgtagacgc ccaggtagtg ggcctggacg ttggcgctgt cggtgagcca
     6601 caccacctcc ttgaggatgc ggccgttgtt ctcgctgacg tcgcgccagc gggtgcccgc
     6661 gaagagagtg tccagggcgg tcgtgacggc gtcggtgagc gcgggggtgt acgcgcccgc
     6721 cgcagcgggg tagtagaact ggatgtagta gcccacctgc aggtacttca ccagctgcgc
     6781 gatgccggtc gtgttgtcgc cggggtagtt cgccgccacg tccttgaggg cggccgcgac
     6841 ggacagcatc cgggcctggt tgaagatgct cgggtcggcg ccggcgctct ggtacagcga
     6901 gttgatgcac tccggggtcg agctcttgat gaaggcgacc agctcggccc cggtgtgggc
     6961 cgcgaagtcg gccggggtgc agctctgtac ggcgagggac ttgaactggg cgggggcggc
     7021 cgcgtcggcc ggctcctcca gcaggcgcgt cgcgccgatc agcgcggggg acagcggggc
     7081 ggcgggctcg ccgggttcct cggagcccgt cgtcgtggtc ggggccgtcg gggcggcggg
     7141 gccgaccggg ccggccgagg cggtcgtcgt ggtcggagcc gacccggcgg tcacgacggg
     7201 cggcgccgcg aaggcctggg ccgggagcac ggcggtggcc gtggcgcaac aggcgacgac
     7261 gcctgccgcg agcacggaga gtctggtgcg caggagcacg ccgaatcctt cgtcgagtgg
     7321 gggcagcccg acgtggggtc gggctgaagg aaggagattt ggcgtggatc ctgtcatcga
     7381 ccgatgatca gaacaatgtc acaggttata ttgcatgaga gtttcggcca tctcgcggct
     7441 cgcaccctcc gagcggctga cctgcgacgt tcccggcctg agcggatcgg cgtatgggag
     7501 ccgaagggac atcgggccac gatccggacg gccgcaccag gccgacgggt cgcacggact
     7561 ggccgatctg cgccccaatg cggaacgccc ggccgggaga ccccggccgg gcgtgcacgg
     7621 cctgttacgc gacaggcctc gaaggtcatc aggcagagtg aaccatccat cagcgcacgg
     7681 gcccccgccg agaacgggac gacctggatc agggccttac gggcccgggc cagtgccgcc
     7741 aggcgccgga gctgtccggc cgtcacatcc gcaccgccga ccggccggcg gatcaccgcc
     7801 tcgtccagga cggcccagta catcggtgcg tcctgccgag gaccagcggc cggtccggga
     7861 gtgtgacgag caggtccggc agtagcgagc ggatactgcc gggtgccgtc ggttcaaggc
     7921 cgctcctcgt cgggggatgg cggaccgagt gggaagcgga tgggactgag cagatagggt
     7981 gcgcgacccg gtgccggccg gttggccagc cgaggaccca gtaccgcgag caactcagct
     8041 gtcatctcgg cgagttcgtc cgggctgagc cagagcgtgc cctggcggta cgagaccgcg
     8101 tcggccaccg ggtcggcgcc gtcgcggtcg aggtaggcgt tgaactcggc gatcagcacg
     8161 gccatggcgg tggcgaagcc gcggcggtgg tcctccggcg tcatcgccgc ggcggcgtcg
     8221 acatcgacga ccgggcggtc ctgccgcagt cggtagtgcc gctcgacagc gccgcgcacc
     8281 cgctgctctc cggccacctc caggaagccg gcctcggcca gcagggcgac atgccggtac
     8341 atggtcacct tcggcacctc gggcatgcgc tcacacagct gcgcggtggt gagcacccgg
     8401 ccgccggaga gcgcgtgcac cacgcgcagg cgcacggggt ggagaagtac gtcggtagtg
     8461 tccatggcgt tacgattcca tgctcgttac tattatcgaa aatggaaaca gtgaccttgg
     8521 agggagcatg cgtcaggcag cggggcgggc ggtgcgggtg aacggccgga ccgtccatgt
     8581 cgaggaatcc ggcagcgggg cggactgggt ggtcttcgag gcgggcgggg ggatggggcg
     8641 cacctgctgg gatccggtgc tgccgtggct cacggaccgg acaaggatgg tcgcctacga
     8701 ccgcgccggc ttcgggcgca gcggccggac ggcaacccag ctgagcatcg aggacctggc
     8761 cgcagacctg gtcgcgctgg tcgaggcggt tgtccccgac cgcttcgtgc tcgtcgcgca
     8821 cagcatggga gggctggtcg cacgccgtgc ggtggagggc ctgggccggc ggctgcgggg
     8881 gatgctgctg ctcgatccgg cagcggaagg cgcgccggtc tacgacgcct tcgaccggac
     8941 cgccgcgaag gtcgaccgtt cactggccgt gacccaggcg ctgttccgct cccgccggct
     9001 ggcccgcctg gccagcggga acatccgccg gctgttcccg acggacacct acgagaccat
     9061 gctcgccgag gacttcgtcc cgtccgggac cgcacagacg aggaaggaga tcaaggccgt
     9121 ggccgcggcc atcccccgct tccgcgccga cccgccggcc ccgccgacct gccggaccat
     9181 cctgctctcg gcctcgcgtc cccaggcggg ccggtcacgg caccacgccg acctggccgc
     9241 gcaccagcgg cgctggaccg agtccctccc ggacggccgg ttcgaaacag tcgactccgg
     9301 ccacttcatc caggccgacc agccgaagat cgtcgccgac agggtcaagc acctcctcga
     9361 ccacgccggc cgggcaggtg ccccgtcgac gtgaccggat ccgcgccgcc tgcccaggcc
     9421 tccgagcctg tccctgcacg gcggcaccct cgctgagctt cgccgcttcg tcggcgagct
     9481 gaccacgtga ggcgggtgag cacgcgctgg tgcagttgca cggcggtttc tggtggctcg
     9541 tgggggcggg tggacgttca tggaaaacgc gtcgttccgc tggcggatcg acctgatcgt
     9601 gacgaccccc ggcctcgccg acagggccgt cgaggcctac gtcgaacgcg ccgccaccca
     9661 cgccgagcgc tggagcgacc acgcgcccgt cagcaccgtc ttcgagctcg gccaactggc
     9721 cgacagcccg cgataattct ccaccgctga ggggaagtcg gcggaaacca agggctggac
     9781 cgacgaccgg tccgacgcaa tgtcagatgg cctgcctggt ggtggggccg cccgagggcg
     9841 gccccaccac ctgtctcgga caatgacgct ttctcagagg ataatgctcg cgacggtgct
     9901 tgtgtttgga tccccctgcc ccagtgcgac cccggcagcc gcgccaacgg tcaggccggc
     9961 gaggatcgcc acccgcagcc gggcctggcg ggccgcgtgg tcagccgccg tgcgacgctc
    10021 gtcggtctcc tgcagctcgt tgtccacatt gtcgagcagt tcgccgtcca tcatggtgat
    10081 gccctccctc tcgttcgacg ggccccggtc ctgctgccgg tcgcaacagc agcaccgagg
    10141 ggatcctggg gccgaagccg agccgcagca ggccgtagcc gatgccggcc agtccggtca
    10201 gcaggccggg tgtgggcacc tcgctggggg tgccgcaacg ggcgccttgc tgttcgacgg
    10261 accgcaccag tcgagcggcc gtacggcgat ggccggcatc ggtcggcatc agctccacca
    10321 gtggttccag cagaccgagt tcgccgtggc ggagcgagtg gcccggcatc ggcacgcggt
    10381 cggcgagcag ggcgaggtgc tggtccgcct tgcaggcgcg cagcgcccgg ccgacccagt
    10441 ccgggcaccg gccggggccg tcggagtccg ccaggtccac cgccgctcgc tcccgcaggg
    10501 cccacgcgac gccctcgtgg ccgtggagga atccgggccg ctcaggacgg ggccgatggc
    10561 ccgccaaggt cctgacagtg tgggcgagtt cggcagctgc cggcagccgc gtctgagcat
    10621 gcacggcctc ggccgcgagc agggcaccgg ccaggccgtc ggcgatgtcc atgggggctg
    10681 ccgggtcgac agcggccgtg tgaagtgcgg cgaggccggc gggcagggcg gcgctcagct
    10741 ccggggagtc cagcagggtg gcgagccggg cggtggcgta gctgattccg ccgagcccgg
    10801 agaagccgcc cggccccacg gcacgcgcga gttcggggtg ctccgccaag agcctcagga
    10861 gctgtgggag gacgcggacg gcctgggcgg cggcctcctg atagcggacc gccccggtga
    10921 gccggcccag ctcggcgagg aacagcgccg ggccggtgta gccgtcgccg agcgccatgc
    10981 ccatcggcaa caccgcccac tgtcctggcc aggcctcctg cagcccgagc cagttcaccc
    11041 ggccctcgcc ccgacaaacc cgggagagca ggtcctcccc gatcccccgt gcgagctcca
    11101 gcgcctgggc accggggtca ccgtcgtagg cgtcctcgga ttcggcagcg gggcgccccg
    11161 gagcatggcg gcccggagac cgtcgtccgg cggccaggga ggcgcggatc agccatgcct
    11221 gccggtcgag gtcgccctcc gacatccccc ggatcgtccc ggcggcggcc gtcagcccgg
    11281 attcgtcgag caggaacggg agttcacgac cgtcccaggt ccgcagggtg cgggcggcgg
    11341 gggtcgtggt gaagaacggg acgtcgccgg cgagcaggtc ggtgagttcg tggggcgcca
    11401 gcacgtgcag gtgcgggtag ccggtctcgt cgtgcagtgc ggcgaaggcc cgctcccgac
    11461 cggagtggtc gcgcagcagc tccggctcgg tcgcctcggc gagcagcgtc gcatagctct
    11521 gactgggccg cgccaccagg cgcatcgcct cacccgcaaa gcgagacaac atcccctgct
    11581 caccgagcag ttcatgggaa tgtgcggcaa tcgcccggta gccggcgcgg aatccgcaca
    11641 gcagccggtc gagctggtcg gccggatcgg cgggtctccc ggccagcatc gggcggttgt
    11701 cggcacccgg ccagcgcgcc gggcggcgga ccagccgcat caggtcggtg cccgcgtccg
    11761 cccacccggg catcgggtcc ggcgtccact ggtcggcctg gccaccaagt gccgagaggt
    11821 cgagtgaacc gccgccgccg aaccacgggt tcggcagcac catggtccgc tgcacggacg
    11881 cggcgagcgc ccgggcggcc ggatcggcgc cgccgtcggt gacgggcgcc cagcacgggt
    11941 ggaacagcgt ctccacgtcc accacgaccg gctggtcgcg cgcggcgatg aggttctcgg
    12001 catggatgtc gaccgcgttc accacgtgca gcagcgcgag ctgggcgccg agccgctcgt
    12061 agaaccgccc gacttcggct tgggaccggc atgggcgcgg cgcgacgtac tcggcccagc
    12121 cgtaccccgc ccgcggcagc aaccgaacgg ctcgcgccgc cagttggggc tggcgtccgc
    12181 cgaaccaggc gagcagttcg ttccaccggg cgtgcagacc gagcgggcgc ggcttgtaca
    12241 ccaggcgctg cccgccgtcg aactccagca cggcgacgga ccggcccgcc gcatgcgggt
    12301 cccccagtcc gaagcggacc cgggtcaacc gaccgggctc gccgtcgagc agggcggcgg
    12361 tgagctgctc ccggtccgcg tggagccgct ccagcagttc ggtggctgcg gccacggtgc
    12421 gcgtgcaccg ttcggccagc agccgggcca gcacgggatg acggtgcagc accgcgccca
    12481 gggccggtcc ggcggcgacc tcgcacagga acgcgtcgaa ccgctcccgc ccgtcctgcc
    12541 cggtcaaggt tccggcccgg cgcgcgtgtc ccaactcctg taccagtgtg cgtccggcca
    12601 gccgcaccaa gccgccggcc aggtggtgcc gtgcaccggc ccacaccact cgccgatctg
    12661 ccgcggcagg gttcaccgcc gcgaagtggc gggaggcggt gagcaggaac ggccgcagcg
    12721 gatgcagcag tcggccctcg gggccggtcc cggggagcga gcggatccgc ccgccgggcg
    12781 ccgactcggc gaggcgcagc gtctgttcca ccaactcggc ccagcgtggc gttcgcccgg
    12841 gcggcagggc atcgcgttcg gccggcgaca gtgcgggcag ccaccaggcg ccagatgccg
    12901 cgggcagcgg aaccgactga gtcgtctgca ctgtcactcc acaactctga cacaccatcg
    12961 cccactctga cagggtggcg catcagattt cccggcaggc ctagcgtgcg gcgaggaagt
    13021 ccgccacgaa atcgcacagc tgggcgcggg tggcggagtt ggtcttgccg atcagactgg
    13081 cgatgtgttt ctcgaccgtc cggggagaga tctgcaggcg ggcggccacg gccttgttgc
    13141 cgacgcgttc gaccagcagg cagaagacgt cgtactcgcg cagggtgacg ccgagcgcga
    13201 cgagttcggc cggaatccgg tccgtgccgg tgcggcgctg cccgaccgga gcgcccagcg
    13261 aacgcagccg ggagcggcac gcggcggcga cggcgtcggc acccgagtgg tggaagtacg
    13321 tctcggcctc ggtcaaccag tcgcggaccg ccccccatcc gtcggtgacc gcggcgtcag
    13381 cgaccagacg caggccgagg tgacgagccg tcgggaagat caccgcgtcg gcctgcgcag
    13441 cgcggcacgc cgccaccgcc tcggccgggc gaccttcccg accgtacagg accgcccggg
    13501 ccaggccgac gaactgccgg ttccaccgca tccggcccgc ctgactcgcg gtgatccgtt
    13561 cgacctctgc ccagtcggct cgcccggcca gcacggacag cagcaggacc agcccgtggc
    13621 tgccggcgag gtggaagtag ttctcctcgt ccggcggggc ggcggcggcc agccgcgcag
    13681 ccagctccgc cgcctgctcg tggtcctcct ccagcagcgc gcagaacagc tcggccagac
    13741 cgagcacgag cggcgcctcc cgcgactcgt tcccaccgct ggtccggaac cgggcgagcg
    13801 ccgcccgcag ttggagcctg cgggcccggt gggcggcggc caccgcgccc accatcaggg
    13861 cgtaccggga caccgagtgc aactgcagtc gctcggtctc ggccctggag ccgtccagca
    13921 gggccgcggc ccggtcgaag tcggctcgca gcaccgcgtc gagcgccagc atcgccccga
    13981 cgttgtgcgc caggctcacg caaccggttc gcatcgcctc ctggtgggcg tggtgcagcc
    14041 cgtccaggtc ggcctcggcg agccaggcgt tgctgcccag gccgatcagc ccgtggttgt
    14101 gccagctcac ctggcggctc tcggcggcca tccgcagcgt gcggcggaag caccggtcgg
    14161 attcggccag ggaacgccca cgggtcgcga aacccatcgc gtaccacgcc tggcaggcca
    14221 gtgcgtggtc accgcgctgt tccgcgccct cgatcgcccg gcgggccagt tgctcgctgc
    14281 ggccgatccg cccctgctcc gccgtcgaca ccgtcaggta ggcctcgacc acgtcgatgc
    14341 ccgcggtgtc ccgcgcaccc gccccctcgg gcagcagctc ccgggccgcg cggacctgtt
    14401 ccagtcccac gtcccactgc ccggccacct gcgccgccca ggccagccgc acgtgcagct
    14461 cgacccggcg tcccggatcg gcctcgacat cggcccggcg cagttgctgc gccacctcgg
    14521 tggcccggtc gagccggccg tcgtccgcca gggcgagcag cagggtctcc agcaactccc
    14581 gtcgcacgcc cgccggtacg gcgtcgtcag gcaggtggat gtccgatccg tcgacaggcc
    14641 ccaaggccga ccgggcttcg tgcagcgccg cgatcgccgt tccgggcccg tggccggcca
    14701 gggcacggcg ggccacctcc aggtagcgga cggcggcggt ccggcggtcc cccgcctgcc
    14761 cgtgcagccg cgcggccacc aggcaccacg tgccgggcag gctcgggtcg agctcgttca
    14821 tggccgccac ggcccgggcg gcgagctcgg cccggtcggc cggcgtgagc cggtcgagca
    14881 acgcctcctg ggtcagcgga tgttcgaagg cgtaccagtc gggcccacgc tcgtcgtccg
    14941 gcaccagcag gccgtcgacg acggcggagc gcagcgagac ggcgggctcg tggtcgtccg
    15001 gcgcggcgca gcgccgcgcc accgacagcg ggaagctgcg gcccagcact gcggcggccg
    15061 acagcagccg gagcgtctgc ggtccgagcc gctccgcccg ctgctcgacc gcccggacca
    15121 gggtgaacgg gatggccgcg cggctggtgc cgaccagccg ccagcggccc tcggtgcgta
    15181 cgagtcggcc ctcggcgcgc atgccgcgga tcaactcggc ggcggtgaac gggattccgc
    15241 tgctgtcggc gagcacccgg tcggacaccg ccacaggcag ttcgtccggc gggcagccga
    15301 gacagttcgc ggtcagcgcg tgcacctgcg cggcaccgag ccggccgagt ctcaacaggc
    15361 cggcttcccc gcgctgggcc agcgtgtccg cgagcgagtg ggcggcgccc ggcgtgtccc
    15421 gcagggtggc gacgacggcg accggcagca gggccaggtt ggccgccaga tactccagga
    15481 ccgccagcgt ctcggggtcc gcgtcgtgca ggtcgtcgat gacgagcagg cagccgcgct
    15541 cccggccgca ggcggcggcc agccggacca cggcctcggc cagcacgatc ggcgaccggt
    15601 cgcaggcgtc cccgatcgcc cactcgggta ccaggcggcc cagcacgggc aggtacggtc
    15661 cgagcgcgtc ggtgggcggc gcgccaccgg cccgggcgag tgacagcagt gcctcggtga
    15721 gcgaccggta cggcacggcc gggccggtgg cgatgcagcg gcccttgagc acggtcatcc
    15781 cggcctcccg ggccagcgtg atcgcctcgc cggccagtct ggtcttcccg atccccggct
    15841 ctccggtcac gcacaccgtg ccgccccgcg actgccgcgc gtcctgcagg acgcggtcca
    15901 gcaggacgag ttcgtcctcg cgtccgacga gtccactgaa ccggtccacg cgcggttccg
    15961 tcatcgtgat cccctccggt ctgccgatcc cgatcaaggc gcaccctatg ccgactcgtc
    16021 gtcgccgttg agggcgtcct ccagccactt cacgaccgtc tcggcggcct cgtcgggccc
    16081 cggcatggca ggcccgacgc cgttctcctt ctgccacagc aggaacatct cgcgctcggt
    16141 cggctcgacc acggtgtggc cgtcggcgcg cagcgtactg acgtgacgtc gggtcgcggg
    16201 cttgcgccac atcgagccgt tcatgttcgg gaagaacagt gcgggccgct cgtgggccag
    16261 cagtaccgtc tgggccggcg tggcggccag cccgagtgcc gccgcagcca gggtgttggc
    16321 ggtggcgggc agcaccacca ggccgagcga gcggtgcgcg aactcggtgg ggttgagggt
    16381 cgggtcgtcg gcgacgtaca cctcgtccgc gtgccaggcc agtacctggg ggtggacgaa
    16441 gcgcgcggcg ctcgcggtca gcaggacccg taacggcagg tcgatctcct ggcggaggaa
    16501 gacgaggtag ttcggcaggt ccttggccgc gatcgagcca caggcgatca cggagagggc
    16561 gtcatttcgc atggctcgga tggtgtccga acccgggccg accccggtat ggggatcgag
    16621 cccccgtttt ccgtcccggc tcccggcagg aagacgggga gcgactaccc atgtccgccc
    16681 accgggcgcc gtgccatcgt cggagtcgcc gatccgccac cagggcgggc ggtgccaacc
    16741 cacctctcca tcaagggagt cgaaccatga agaagatcgc tgtgcgcaag accggttcca
    16801 tcaagctcac ctcgccggcg tcctacgtcc tggtggtctg ctgacccggt gacacccccg
    16861 ggcctgcgtg cagccagcac gcaggcccgg gttcgtcccg ccgcacccgc ccgagcgggc
    16921 cgcacccgtc cgggaggccc gcacccctcc gagggagaga tcatggcgac caccgacctc
    16981 gcgttccatc cgctcacctt cgtcaccgaa cgcgacggca cgctggtggg ccggcccgac
    17041 accgggtcct tcgcactgct cccggaggac ggcgcggcgc tgctgcgacg cctggccgac
    17101 ggcatgccgc tcgccgaggc cgccgcctgg tacgacgcgg cctacggaga gccggtcgac
    17161 ctggccgact tcatcgagac catgcgcgat ctcggcttcg tccacgagcc cggcgccgcc
    17221 gccgagcccg tgcccgtacg cctccaggcc tggggacgtg ccatgttctc gccgctcggc
    17281 tggagctgct acgcgctgat caccgcactg gcgatcgcgg cgatgatcta cgagccccga
    17341 ctgcagccgc acacccggaa cctgttcttc gtcccgtccc tggtcgcggt ggaggtgacc
    17401 ctcgccgcgc tgcagatgcc actcatgctc tggcacgagg gctggcacgt cctggccggc
    17461 cgcaggctcg gcctgcccac cggcctgggc atcggacgac ggctctactt cgtggtcttc
    17521 gagacccggc tcgatgcgct gttcggtgtg cggcccgcgc agcgctacct gcccttcctg
    17581 gccgggatgc tcggcgaggt cgtgctcttc ggcgcgctca ccctcgcggc ggcggtcgac
    17641 ctcgcgaccg gaccgtcctg ggccgggcgg ttcgccctcg ccgtggcgta cctgatcctg
    17701 ccccggctgg cctggcagtt cctgatcttc ctgcgcaccg acctctacta cgtcctcgcc
    17761 acggccctgg gctgcgccga cctgcacgag gtgggttcgg cctatctgcg ccaccgtctg
    17821 ggccggggcg gctgggcgga ggaccgctgg acggcgcggg agcgggcgct ggccccttgg
    17881 tacgccctgc tgaccgcgat cggcaccgcc ttcctgctgg tcgccgccgt gttcaccgtc
    17941 gtcctgccgg ccgtgacgtt cgcccggcga ctcgccgacg gcatcgcgca aagctcgctg
    18001 agcgacagcc ggctctggga tgccgccgtc gccctgctcg tcatcgtcgt ccaggtcgtc
    18061 gtgctgcccc tgctggtcgg ccgcaggcaa cgccgcgccg ccgcgtgacc ggcccgcgca
    18121 ctcacgaaag gaaaacccgt gacctcccac acctggcgcc tccagcccga aggcaccgcg
    18181 cacgacgacc ggtacgacgc ccgagccgac tgccaccggc ggctgcgcgg accgtacacc
    18241 ggtctgggca ccctgctgcg ctcactggtg ccggatgcgc accgggcccg cccggagctc
    18301 gtggcgcacc acgccgtcga aatcctgtcc gctgctccgg aactcaagga cctgatcggc
    18361 gccggaccgc agaccctcac ctcgctggcc gtgcccaacg agcgcacccg cctctacccg
    18421 gcgaagcgca cccgccgtct cgcccacggc atcatcgagt tcctgcacgg ccacgcccgc
    18481 gagcgcggcc acgcgctggc cctgcgcttc gaccgggtcg acgaggccga tcacaccgac
    18541 caggagttcc tcgccatcct gctgcgccgg gccctgccgg acctggtgat ggtcaccgtg
    18601 cacaccggcg gcgccgacct gatccccgaa ctcaccacgg ctctcgccgc ccatgccacc
    18661 cacaccatcg cccaacatcc cgacgagcac gaaaacctga cggatcatca gaagctggcc
    18721 ctggcctacg tcgagtccga cggcacctcc cacgaccccg ctgaacaagc cgcctaccgc
    18781 cgcgtcgacg ccgccgagcg ggcccgactg cacgaccagc gggcggccga gctgcgccgc
    18841 agcggagact ggagcctgtg tctcggggcg atcccctatc acctggagca cggcagcgac
    18901 cgggaggcgg ccgccgacgc gttcctcgaa gccgccgagt acctggtctc gatgggcttc
    18961 taccactcgc tgctcgacgt ggccggacgt ggcacggccc tgatggaccc ggccgaggag
    19021 ccccggaagt actggatgct gggcaccaag gtcaccaccg cactggcgat cctcggccgg
    19081 ccggaggagg ccgaacggcg ctacatcgag ctgcgcgcca tgttcgacca gccgatgctg
    19141 cacatcttct ccggctacgc cctggccatg ctctacacgc gctactaccc ggccgagcac
    19201 aaggaccacc agctggccaa ggcccacctg cacaacgtgc tcgcgatggc ctccctgctg
    19261 ccggaccacg accagcgtgt cttccagtcg gtcttcaacc gcaacggcct ggccctggtg
    19321 gagctccagc tgggcaaccc gaccgaggcg ctgcgcctgg tcagcaccgg tctggccgac
    19381 atcgaccgcg aactccccgc cgagaagcac cgcttgcacc gctccgtgct ggtccacaac
    19441 cggggccggg tgtacaccgc gctcggccgg ctggaggagg cgctggccga catcgacacc
    19501 gtcatcgagc tggatcccaa ctacccggac tactacttcg accgggccga cgtgcggcgc
    19561 cggatgggcg acctgcccgg cgcgttggcc gactacagcg agtcgatcac cttcgccgcg
    19621 ccgttctggg agatgcacta caaccgggcc gacctgcgcc tggaactggg tgacctggcg
    19681 ggcgcgatcg cggacctggg gtacgtactc gaactggaac ccgacgagct ggacgcccgg
    19741 atcaacctcg ccagcctgct gcgggagcag ggcgatgcgg cgggctcgct gacccaggtc
    19801 gaggaggggc tgcgccacca tccgggcgac gcccgcctgc tgtgcgcccg ggggctgctg
    19861 gcgctggacg cgggcgccga ccaggaggcg ctgcgcgact tcgacctggc gctgaccgcc
    19921 gagccggacc tggtgagcgc gctggccaac cgcgcggccc tggtactgga gacgggcgac
    19981 caccgcaccg cagtcgcgga tctcacccgg gcgctggcga tcgaggccga cgatccggac
    20041 ctgctctaca accgtggtta cgtccaccag agcgccggtg actgggagtc ggcccgccgc
    20101 gactacaccg ccgcactgct gctgcccggt gccgaccggg ccgacctgct gcgacagcgc
    20161 gccgaatgcc acctcgcgct gggggatccg acggcccatc aggccgacct ggcggcggcc
    20221 gagtcggctg cgagctcgcc gaacgcggtc gcggatccgg tgagggtgtc gtgacggccg
    20281 gaccggatcc tggcaccgtg accggtccgg tgacgccccg gccgcagccc ccggccgtca
    20341 gcggaccggc cctgcggagc gtcatgcgcc gctgggccac gggggtcgcc ctggtcaccg
    20401 ccacggccca gggccggccg accggttgca cggccagctc cttcacctcg gtctcgctca
    20461 gcccgccgct cgtgctggtg tcgctgtacc ggagcagccg caccctggcc gcgatcacca
    20521 gccagggtgc cttcggcatc aacctgctcg gccgccatca ccaggacctg gccgaccggt
    20581 tcgccaccgc accggccgaa cagcggttca ccggcgtcgg ccaccggctg gtccgggacg
    20641 tcccggtgat cgacgaggcg atggcggccc tggtgtgccg ggtcgagcgc accgtcgcca
    20701 ccgccgacca cctgctcgtg ctggggcagc ccatgtggtg cgaccagaac ggtgccgccg
    20761 accccctggt gcacttcgga agccactacc agtgtctggc cgtgggatcg gcacgtgcgt
    20821 gatccggtcg ctcgtccgtg ggggacgaac agtgggacca cgggtgatca tcggcgccgt
    20881 cccggcgggt acgacctcgg tgccgcggct cgccgagcgg acggagtgag gcggatccgg
    20941 cagtcggcgc cggcgggggc gcggcatcga ggtcgtcggt gccgcggccc gggcggtgcg
    21001 gcgccaggcc tcgcctacgg cgccgcgctc actcgccccg gggcggcgcg ggctacgtct
    21061 ccaggcccgc cggcgtccgg tagcaggaca tcacccgggc gatggaggag tccggctccc
    21121 ggccctcgcg gatggcggcg acgaacgcgc ggtcctgcag ttcgatgccg tccgtcgacg
    21181 ctccggtgac cgtggcgtac gaccgcgagt tctgaccgca gccaggaagc cgggctgcct
    21241 gtccttgatc ggcagcccgg ccgggaccga cgcgcacggc ggccgtccgg cggcccgtcg
    21301 gcacccgcgc tgtcgcccgg ccccgaaggg cgccggctgc gaccgtcagt agccgctgcc
    21361 gcgcttgacc tgggcccgct cgacctcggt ggtcgccccc ttgtggtcca aggtggcaca
    21421 cgcatcggcg atgtcctggg tcaggcggtc gatctggccg cggctcaggg tctccttgac
    21481 cagcgccctg aggatcttca cccgctccgc tttgggcggg agcgtgtacg ccggcaccat
    21541 ccagccgcgc tcggccgaga gttgccaggc gatgtcggac tcgtcgtagg agtgcttgcc
    21601 ggcgaggcgg aaagcgacca gcggcagctg ttcgagatcg ctgccgatca cttcgaagcg
    21661 gccgctgtca cgcaggttct ccgccaacgc gtgggcgttc gtctgcatcg tctccatgac
    21721 gtaggtgtag ccctgacggc ccagccgcac gaagttgtag tactgcgcga gcaccatcga
    21781 cgcgccggtc gagaagttca gcgtgaacgt cgcatcggtc ttgcccaggt agttctcgta
    21841 gaacacgagg tccttggcca gatccgactc ctcgcggaag accagccagc cgatgccggg
    21901 gtagaccagg ccgtacttgt gtcccgagac gttgatcgat cggacctgct ctagccggaa
    21961 gtcccatttc gagtccgggt agaggaaggg ccacacgaag ccgccgctgg cgccgtccac
    22021 gtggatcggg atgtcgaggt cccgcttctt gcggatctcc cgcaggagct tgtcgatccc
    22081 gacgacgtcg tccttgtggc cggtgaacgt ggtgccgacg acggcgacga cgccgatcgt
    22141 gttctcgtcg aggtggggct ccacgtcctc cgggccgatc gtgtacttgc cctcggcgag
    22201 cggcacgatc cgcggctcga cgtcgaagta gcggcagaac ttctcccaca cgacatgaac
    22261 gtcaccgccg aagaccaggt tgggccggtc ggccgacagg ttggccgcct tacgacgctc
    22321 ccgccacttc cacttcagcg acagcgcgcc gagcatgatc gcctcggacg agccctgggt
    22381 ccggcacccg gtggtcctgc ccggcgcgtt gaagaggtcg gcgagcatcc gcacgcagcg
    22441 ctgctcgatc tcggcggaga tggggtactc cgcatgatcg atgaagttcc ggtggaggtt
    22501 ctcggcgatg atccgctgcg cctccggctc catccacgtg gtgacgaacg tggcgaggtt
    22561 gcgctgcggg tcgccctcca tgacgaggtc ctcatccacc agccgcatag cgtccgtcgc
    22621 ggtcatgccc tcctcgggaa aggtctccga gggagcgggc acggtcagga aacggttacc
    22681 gaacaggtcc ccgacatcac tcttggtcat gtcggcgact caaccagttc cgggccggga
    22741 gccgtgctca ggactcgtgc gccgaatcga aagcacccga acggtctacc ttcccggtcc
    22801 gctcgcacgc c
//
