LOCUS       NZ_CP026498            21059 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. CB01881 chromosome.
ACCESSION   NZ_CP026498
VERSION     NZ_CP026498.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB01881
  ORGANISM  Streptomyces sp. CB01881
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     A 3-hydroxy-3-methylglutaryl-CoA synthase gene based probe for the
            discovery of the acyltransferase-less polyketide synthases
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) Xiangya International Academy of
            Translational Medicine, Tongzipo, Changsha, Hunan 410000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002953255.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 02:39:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,978
            CDSs (total)                      :: 7,904
            Genes (coding)                    :: 7,565
            CDSs (with protein)               :: 7,565
            Genes (RNA)                       :: 74
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 124 of 339
            Pseudo Genes (incomplete)         :: 251 of 339
            Pseudo Genes (internal stop)      :: 10 of 339
            Pseudo Genes (multiple problems)  :: 45 of 339
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:44:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9339645
            Orig. end                         :: 9360704
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026498.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21059
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="33"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21059
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21059
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11059](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11059
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(512..958)
                     /locus_tag="C2142_RS30435"
                     /old_locus_tag="C2142_30455"
     CDS             complement(512..958)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071601.1"
                     /locus_tag="C2142_RS30435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30455"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_148646054.1"
                     /transl_table=11
                     /translation="MTTAYEPLQRFASYGILRRPDAVLMVRIGPSSKDDHGRWMLPGGK
                     VEHGEHPRDTVVREFKEETGFDVAAGRLLDLDAEHRLLSIGIDFHAVFALYEIEVTGGE
                     LTHGGHGGVDASAWIPFSDLAGLPILPPIRDALRRHLGPVAGLG"
     gene            complement(1005..1772)
                     /locus_tag="C2142_RS30440"
                     /old_locus_tag="C2142_30460"
     CDS             complement(1005..1772)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="C2142_RS30440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30460"
                     /product="ABC transporter permease"
                     /protein_id="WP_148646055.1"
                     /transl_table=11
                     /translation="MTRVLSLLRHDATWLRREPAPLVTVLLTPCLLMLFIKPLYSGALS
                     QLGYGDADGAQLAVPGMTGMFSFFMTGLVTESYFREHGLHTWQRLRLSPLRTWELLVGK
                     AALCAALVVGQCVFLFVLGWAVIGLRVHGSLLALLVVMVALAVCVVSFALALCAVSPTR
                     RQAFAVERMVTLSWTVFGGALVPTELMADWIGWIARFTPVYWAVGGFRKVVLDGAGVGG
                     VLPNAGALLGFAAAFTALALWRFTMDKDRRHWA"
     gene            complement(1741..2625)
                     /locus_tag="C2142_RS30445"
                     /old_locus_tag="C2142_30465"
     CDS             complement(1741..2625)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024991.4"
                     /locus_tag="C2142_RS30445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30465"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_208693241.1"
                     /transl_table=11
                     /translation="MLRGLTLSADRGEVLAVLGPNGAGKTTLMSVIAGLLRPDGGSVQV
                     LGTDVAGGAKALRGRLGLAGQEIAVYPVHTVEENLRFFGSLGGLRGRELTESVDGLIDA
                     LELTGQRGQRAAELSGGQQRRLHAGCALVHRPEVVLLDEPTAGADPQTRLRLLEVVQRQ
                     AARGTLVVYTTHYLAEVEELRARVVVLAGGRIVADGTVDGLIAENTRSELALRFDGEPP
                     EIIWPGARVLADTVFLPTARPAVDIVKALEAVAGHRERLQGVEIARADLERAYFNILAG
                     EASHDTSPVTAPA"
     gene            complement(2679..3113)
                     /locus_tag="C2142_RS30450"
                     /old_locus_tag="C2142_30470"
     CDS             complement(2679..3113)
                     /NRPS_PKS="Domain: Polyketide_cyc (6-134). E-value:
                     1.2e-21. Score: 69.3. Matches aSDomain:
                     nrpspksdomains_C2142_RS30450_Polyketide_cyc.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022072.4"
                     /locus_tag="C2142_RS30450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30470"
                     /product="SRPBCC family protein"
                     /protein_id="WP_162002594.1"
                     /transl_table=11
                     /translation="MRERLVASADDVWKRICDIESYPTFMDSVIRTQVLSEETRPDGIT
                     EAVTEWEVLLKGSVLKWSEREVRDPSQWRLTYEQVAGDLERFAGFWQVTKVTEEITEAT
                     LEVDFEIGIPMLRPMLEPVAVRAIEKNSSDMLVSLGRRAD"
     aSDomain        complement(2712..3095)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS30450_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="1.20E-21"
                     /label="C2142_RS30450_Polyketide_cyc.1"
                     /locus_tag="C2142_RS30450"
                     /protein_end="134"
                     /protein_start="6"
                     /score="69.3"
                     /tool="antismash"
                     /translation="ASADDVWKRICDIESYPTFMDSVIRTQVLSEETRPDGITEAVTEW
                     EVLLKGSVLKWSEREVRDPSQWRLTYEQVAGDLERFAGFWQVTKVTEEITEATLEVDFE
                     IGIPMLRPMLEPVAVRAIEKNSSD"
     misc_feature    complement(3106..3119)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            complement(3149..4375)
                     /locus_tag="C2142_RS30455"
                     /old_locus_tag="C2142_30475"
     CDS             complement(3149..4375)
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (30-344). E-value: 4.1e-84.
                     Score: 274.4. Matches aSDomain:
                     nrpspksdomains_C2142_RS30455_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012428.4"
                     /locus_tag="C2142_RS30455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30475"
                     /product="aminotransferase class III-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_148646058.1"
                     /sec_met_domain="Aminotran_3 (E-value: 9.8e-81, bitscore:
                     270.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLLDLIRDHQSSGRALLFRLMGATDPEVSGSGSWVTTGAGARYL
                     DLGSFSVFLLGHSHPQVVEAVAEQLARLSGSTRTLPNELNARAAADLAEFAPPGLDKVM
                     LLNSGAEAVEAAIKLARARTGRVPLAHLAGSFHGKTVGALSLTDAALFRDRLGPLLPDV
                     IRLPRDDAGAAAELIRRHRPAAVFAEPVQGEGGVYPLTPGYATALREACDEAGTLLVFD
                     EIQCGLGRCGSFWAHEDLGVRPDVLLSGKALGGGVIPVSAVIATEDAFQPYDRDPLLHT
                     STFGGNPLAAAALTATLKVLAAEDVPGLARSAGGRLREILEDLVRSWPRLFTEVTGRGA
                     LLGLHGTQPDVAGEMMRAALAENLLLTPCLTAPSILRLTPAAFIGAQDLAFVAEKLNAA
                     ARRTQLELD"
     aSDomain        complement(3344..4285)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS30455_Aminotran_3.1"
                     /evalue="4.10E-84"
                     /label="C2142_RS30455_Aminotran_3.1"
                     /locus_tag="C2142_RS30455"
                     /protein_end="344"
                     /protein_start="30"
                     /score="274.4"
                     /tool="antismash"
                     /translation="GSGSWVTTGAGARYLDLGSFSVFLLGHSHPQVVEAVAEQLARLSG
                     STRTLPNELNARAAADLAEFAPPGLDKVMLLNSGAEAVEAAIKLARARTGRVPLAHLAG
                     SFHGKTVGALSLTDAALFRDRLGPLLPDVIRLPRDDAGAAAELIRRHRPAAVFAEPVQG
                     EGGVYPLTPGYATALREACDEAGTLLVFDEIQCGLGRCGSFWAHEDLGVRPDVLLSGKA
                     LGGGVIPVSAVIATEDAFQPYDRDPLLHTSTFGGNPLAAAALTATLKVLAAEDVPGLAR
                     SAGGRLREILEDLVRSWPRLFTEVTGRGALLGL"
     gene            complement(4375..5607)
                     /locus_tag="C2142_RS30460"
                     /old_locus_tag="C2142_30480"
     CDS             complement(4375..5607)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) azdH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.4"
                     /locus_tag="C2142_RS30460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30480"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_148646059.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.6e-06, bitscore:
                     27.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="azdH (E-value: 5.8e-45, bitscore: 152.5,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 9.8e-09, bitscore:
                     34.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.7e-07, bitscore:
                     30.4, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDAYDYRNGIGALWPDTEHLLPERATTELAALAEQNDLTGRLAD
                     RSIELLRENGYFGAPVPKDFEGGGASITECCALQRRIGAADPALAVAVNMHLFSVGVVV
                     EHWYRERDESWLLLEAIASQNRIVASAFAEPGLNGSLTRSNTVARRVGDNWITNGLKVP
                     CSLAERSDLLCLQMIDEAGGPESLLVALVVNGSPGIAVERTWNTLGMRASESDTVRFTD
                     CEIPDDLVFHRSEPGSLGDEVFAAGLGWFCVTATACYLGVVSAAVDQARAALGRSRINH
                     LGATRSQLPSFQSALGEIISAALPLEAATAGLARQLDERRTDPRSLVPAMLALKDQAAQ
                     MAVRAVELAAELVGVASYSATGPASRLIRDVQAARFHPPTRFATRQLLGRWALGLPWSF
                     ELSEQPTEGAS"
     gene            complement(5604..6620)
                     /locus_tag="C2142_RS30465"
                     /old_locus_tag="C2142_30485"
     CDS             complement(5604..6620)
                     /NRPS_PKS="Domain: NAD_binding_4 (53-193). E-value:
                     1.1e-19. Score: 62.5. Matches aSDomain:
                     nrpspksdomains_C2142_RS30465_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013530.4"
                     /locus_tag="C2142_RS30465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30485"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_162002595.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.1e-07, bitscore:
                     29.2, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.4e-17, bitscore:
                     62.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRPGTMLVTGATGVVGVEIVERARAAGWHVTASSARGAADAVAW
                     RMGEAPAPEQLAGPWDVIVHAAARPRWNLPAQEAKDSNVAPVAALEPLVGQATHVIHVS
                     TAYATGLRGNTRSSDLADYRNTYEWSKAEAEREATSRYGATIVRPPLVVGRRSDGAVSR
                     HTGLYSVMQSGVTGMLPVFIGEVDAPVEVVSTCDIATCVLEIAETGPRAEPVVLGAGEQ
                     VLPLKGVVDSMYLSLNRWRASHGYEPLETPGFVTPDQWDRFYLPFAKPHLTNRQLRQID
                     LLGEFIPYMSVGEPIGVNWQVDDPAGAIETAIAAWADRRPHLAKSSPRPWVGEEGAA"
     aSDomain        complement(6042..6461)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS30465_NAD_binding_4.1"
                     /evalue="1.10E-19"
                     /label="C2142_RS30465_NAD_binding_4.1"
                     /locus_tag="C2142_RS30465"
                     /protein_end="193"
                     /protein_start="53"
                     /score="62.5"
                     /tool="antismash"
                     /translation="EQLAGPWDVIVHAAARPRWNLPAQEAKDSNVAPVAALEPLVGQAT
                     HVIHVSTAYATGLRGNTRSSDLADYRNTYEWSKAEAEREATSRYGATIVRPPLVVGRRS
                     DGAVSRHTGLYSVMQSGVTGMLPVFIGEVDAPVEVV"
     gene            complement(6617..7147)
                     /locus_tag="C2142_RS30470"
                     /old_locus_tag="C2142_30490"
     CDS             complement(6617..7147)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019434288.1"
                     /locus_tag="C2142_RS30470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30490"
                     /product="hypothetical protein"
                     /protein_id="WP_241002867.1"
                     /transl_table=11
                     /translation="MTVRTNDSLHRQVAQVSHGALLIMVGAQSALEDIEGGVPAGQWHL
                     VLAQTRYLVMVCCQAGGLRSGAEPYVAEDGGAIDPYTHVPAADWESGHRLISEAREFAA
                     AAPSEERAGDWLRRVRSWVSEIEATLGLADPLPQLRSPEGMFGALRLVRGWHALADQLG
                     LPPLLPTEWTKPL"
     gene            complement(7144..8058)
                     /locus_tag="C2142_RS30475"
                     /old_locus_tag="C2142_30495"
     CDS             complement(7144..8058)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS30475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_30495"
                     /product="hypothetical protein"
                     /protein_id="WP_206671052.1"
                     /transl_table=11
                     /translation="MDSSFGEPLLITAAGSVIAGFGNANSDLDLYAIVPDEVASTLPLM
                     SYPEGSRIDVVLHGAGQVTKRYEELTTTHWPPAEIGPGDLGTRRQVLDSVSRFGLGLLL
                     TGTPEWSSWQRRLDAELSGWISSWYAAEAVRKRIAARVFAERKPMVAALRIGEALAAAL
                     ERRAVERGERYFKPKWLGEKLRKLDDRDGLAAFELAMCPPASPDKVPAYLAQVGELLDH
                     YARDVDGSAWRVRLSHARGTEQYEFGESRLVTRWGLRTLSVPAGGPVDHAKTWTFALDE
                     EWHPDVAALFVEDLLWLGVECPV"
     misc_feature    8237..8252
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(8237..8255)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.46"
                     /tool="antismash"
     misc_feature    complement(8240..8255)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.63"
                     /tool="antismash"
     misc_feature    complement(8295..8308)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: strong, score: 20.01"
                     /tool="antismash"
     misc_feature    complement(8326..8338)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     gene            8662..9192
                     /gene="idi"
                     /locus_tag="C2142_RS30480"
                     /old_locus_tag="C2142_30500"
     CDS             8662..9192
                     /EC_number="5.3.3.2"
                     /GO_function="GO:0004452 - isopentenyl-diphosphate
                     delta-isomerase activity [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="idi"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126459.1"
                     /locus_tag="C2142_RS30480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30500"
                     /product="isopentenyl-diphosphate Delta-isomerase"
                     /protein_id="WP_241003300.1"
                     /transl_table=11
                     /translation="MLELVDPQGVTVGISEKIAAHESPGRLHRAFSVFLFDDEGRMLLQ
                     QRALSKYHFPGVWSNACCGHPLPGEAPFQAAVRRVGEELGIAPALLMEAGTVTYRHPDP
                     QSGLVEHEYNHLFVGLVRAEPRPDPDEVAGFALVTPDELRERRAVDTFSGWFQDVLEAA
                     LPAVKRLDADIHW"
     gene            9240..9974
                     /locus_tag="C2142_RS30485"
                     /old_locus_tag="C2142_30505"
     CDS             9240..9974
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126460.1"
                     /locus_tag="C2142_RS30485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30505"
                     /product="hypothetical protein"
                     /protein_id="WP_241002868.1"
                     /transl_table=11
                     /translation="MPTSVADQHWLGTEVDIDWTDLRSAHAQCRSVLRRLAADSSLLTH
                     LVDRLADDKDLLADADHHPVMDRLTLWHDPDRGIYLRLHVSPGTNELIPHDHKYSFTTY
                     ILRGSYTHVWRRREGSYQGDFTSDQAPLGLVTSERVGSCYTLGYSLIHQTVMEAGTVTL
                     FMRGPKEQARSYAALDMLDRLTVDAATEPVASEQRRHTDGERGLGFDEYLRLRDRLSAQ
                     GVLEPSVSPTDITTTHPERRPS"
     gene            10001..11059
                     /locus_tag="C2142_RS30490"
                     /old_locus_tag="C2142_30510"
     CDS             10001..11059
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126461.1"
                     /locus_tag="C2142_RS30490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30510"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_148646636.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 7.1e-33, bitscore:
                     112.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQDRIAYYQRHFSDLFGRYFEDLRNDFDGPELSRFTPRCLDLLQE
                     LSLRGGKRQRVAFMYEAARLVTGEHLPGLDEAALSIELLQTHLLVHDDIIDDAPTRRGG
                     PSTYYAYRAEFPDQPQTALGLALLAGDLAAFLSLQVLLDADLPLALRTGMVDLQTRAAA
                     ATFVGQIFDLERDFPGIPSEEMLHSVSDYKASRSSALAPVQLGLLVAGEDPAQHAETLS
                     RYALMFGISGQMCDDYLSLFGDEAVTGKPNTADIRDGRRTYAVRALLAAASETERAVVE
                     SVLGSPDCTNEDVNKLREIASRHGVDRQLRSDMHRYAELACKEAAGWRPRWREEAVAFF
                     ERVPVWGVERTL"
     gene            11056..11847
                     /gene="uppS"
                     /locus_tag="C2142_RS30495"
                     /old_locus_tag="C2142_30515"
     CDS             11056..11847
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126462.1"
                     /locus_tag="C2142_RS30495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30515"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_241002869.1"
                     /transl_table=11
                     /translation="MTSTTDSATAGSLIGRPGAAGPSHAVGGGAVPRHLGLILDGNRRW
                     ARARGRSASDGHRAGFSRIPEVLRWCESLGVEVVTLWMLSTDNLSRDPAEVDALVSIIA
                     DTVDGLTAHGGWRIRHLGVRSAVRQPLLDALDRAVADTRGVAGLQVNLAVCYGGREEII
                     DACRSLLEQYRAEGLSTSEAAEKLSVETISDIISAGAPEPDLIIRTSGEQRTSGFMLWS
                     GMYTDYWFTPIYWPDFDQAALDEALAHYRRSLSGRLPARVG"
     gene            11875..12741
                     /locus_tag="C2142_RS30500"
                     /old_locus_tag="C2142_30520"
     CDS             11875..12741
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071606.1"
                     /locus_tag="C2142_RS30500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30520"
                     /product="hypothetical protein"
                     /protein_id="WP_148646062.1"
                     /transl_table=11
                     /translation="MAPKPISRGCAIGLIGIDGVGKTTLAGELERRLTERGVPAVLLSR
                     RQYLKTRPHDFVGDTMATLYEGSLRTLYGFAGLAGGGTLGDHFPPPAGPVMSADFERLL
                     DGAAITGNDPHALITSMLCEIAGHLAFREAVVAPAVRAGKVVIEDTHGIKMVVKLYLLA
                     TSLAGSGDLSNQSLEAVLKAGITALRPDPAASVPVLVQVDPEIAYQRRVAQHGRVGGME
                     HYGPVGRAVGHDSYVELQSRSQKIFDEIGTLWGCLRVELPPQDREGGLRTAVDQILAAV
                     DGLAEGQ"
     gene            12745..13455
                     /locus_tag="C2142_RS30505"
                     /old_locus_tag="C2142_30525"
     CDS             12745..13455
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071607.1"
                     /locus_tag="C2142_RS30505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30525"
                     /product="hypothetical protein"
                     /protein_id="WP_241002870.1"
                     /transl_table=11
                     /translation="MTDQLAIGLGPHWIDHLPALDWTNLRAGHRQARSVLTRLAGDREL
                     LTRLVHEIEHDEQRMTASEIHPLINRLILYQDDARGFQIRLHMSPGSRELVPHDHKYTF
                     TAYVLQGAYVHVWRRRADRGEGEFTGDDIRPGIVSIERPGTCYTFGHPLIHQTIMVPGT
                     VTLFMRGPRVKQRSHAALDMLPQADNWPPPSELGKPKHANGQRPVTLDEYRAMRAQLVD
                     SGLIDVISASGSTG"
     gene            13452..14150
                     /locus_tag="C2142_RS30510"
                     /old_locus_tag="C2142_30530"
     CDS             13452..14150
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013424.4"
                     /locus_tag="C2142_RS30510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30530"
                     /product="undecaprenyl diphosphate synthase family protein"
                     /protein_id="WP_148646063.1"
                     /transl_table=11
                     /translation="MTPRHVGVILDDGANRAGTDGPPEAEAYRRSCLKQLEIVEWCRAE
                     GVSEVTLYIPPPTSPLADEELEAVWGEVLDQLRQDRAGIAPVTLHHLGDPALLPAALAA
                     RLPGRTGPDSRNGHGFTVNLVLGYEGRNEIRDAVSSILVAAQDESRSLAEAISGLDAEQ
                     LGAHLLTGTLPPIDLVIRTAGRRHLAGFLPWQAAYAEFHFTTASASEFARGDLTVALAD
                     YSRRNRRFGK"
     gene            14159..14866
                     /locus_tag="C2142_RS30515"
                     /old_locus_tag="C2142_30535"
     CDS             14159..14866
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126466.1"
                     /locus_tag="C2142_RS30515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30535"
                     /product="hypothetical protein"
                     /protein_id="WP_241002871.1"
                     /transl_table=11
                     /translation="MMETHDAESFDLAAACSEIDWDDPRRSSRQTRKLLGRLAADRELL
                     TDLLVGIESDPLRLGRSERHPLMHRLSLYEDPERRCQLRLHFFTGRDRDLVPHDHKYPF
                     SVHVLSGGYLHVWNRRTDEAQIGDFTSEDVTPGIVTLERPGTSYSFQNSLVHQTIVLPG
                     TVSLFLRGPKRQDRWHAAKDMLHLLNGYEAPSEGKKTHLGAEPITTDEFLVIRDDLARR
                     GIITDRRPSGVAA"
     gene            14853..15458
                     /locus_tag="C2142_RS30520"
                     /old_locus_tag="C2142_30540"
     CDS             14853..15458
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126467.1"
                     /locus_tag="C2142_RS30520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30540"
                     /product="hypothetical protein"
                     /protein_id="WP_148646064.1"
                     /transl_table=11
                     /translation="MSLPDFFIQPVVQLLAQTASPYDVPADPEIFNENWLEPTLTRTLA
                     LLREADPEKLAATSVTGSGLTYLSLASDVEKDYSVHLRIAGEGKPVPRDPAEKAVVLTL
                     GGTMELEAYRHGGDVESDTPWYVRQFTPENIYACHPGTLHSVEQSEDAVQLVISRGEAP
                     AIGRPLDADEYRLAAERTRQLLDRVLESRRTETAQIAS"
     misc_feature    complement(15741..15755)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.08"
                     /tool="antismash"
     gene            15766..17688
                     /gene="dxs"
                     /locus_tag="C2142_RS30525"
                     /old_locus_tag="C2142_30545"
     CDS             15766..17688
                     /EC_number="2.2.1.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009240 - isopentenyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dxs"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004943726.1"
                     /locus_tag="C2142_RS30525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30545"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_148646065.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 5.5e-108,
                     bitscore: 359.1, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALLTRIRGPRDLDKLTPGQLATLAEEIRTFLVTEVSKTGGHLGP
                     NLGVVELTVALHRAFDSPRDRILFDTGHQSYVHKLLTGRQDFSRLKMKGGLSGYPSRAE
                     SEHDVIENSHASTVLSYADGLAKANRIQGRNDPVVAVIGDGALTGGMAWEALNNIADAK
                     DLPVVIVVNDNERSYSPTIGGLANHLATLRTTQGYERFLSWGKDALQRTPVVGQQLFET
                     LHGAKKGLKDFIAPQGMFEDLGLKYIGPIDGHDLTALESAFTKARGFGGPVIVHCLTEK
                     GRGYHAAENNEEDRFHAVGVIHPDTGLPVKSSGKDWTSVFGEEMVALGHEREDIVAITA
                     AMLHPVGLAPFAKAFPDRIFDVGIAEQHAVTSAAGLATNGLHPVFAVYATFLNRAFDQV
                     LMDVALHRLGVTFVLDRAGVTGTDGASHNGMWDMSILQVVPGLRLAAPRDADQVRAQLR
                     EAVEVKDAPTVVRYSKGTVGPAVAAVGRIGGMDVLREAPGAAERADGRRADVLIVSVGA
                     MAPTSLEVADLLAAQGITATVVDPRWVKPVDEALPGLAAGHRAVVTIEDNGRVGGVGAA
                     VAQALRDAEVDVPLRDFGIPQEFLDHASRGEILAEIGLNAPDIARQVTALVARLAKLDV
                     ATVEA"
     gene            18418..19068
                     /locus_tag="C2142_RS30530"
                     /old_locus_tag="C2142_30555"
     CDS             18418..19068
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118382.1"
                     /locus_tag="C2142_RS30530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30555"
                     /product="DUF3152 domain-containing protein"
                     /protein_id="WP_241002872.1"
                     /transl_table=11
                     /translation="MVTAALVAGLLWWHPWTPAATGRQKPMEFTTAGGGSPRFGTGEKL
                     YRYKVRAENGIKETPDQFAAEVDAVLGNVRLGWAADGTRSFQRMPADPVDFTVYLATPE
                     TTDRICGQYGLDTGGWVNCGVGHQVVINLKRWNELTEFYSGRPELYHALAVNHEVGHVL
                     GLGHVDCPGPGLPAPVMMQQIKGLHGCVPNGWPYSETGTLLTGPAVEAATPAP"
     gene            complement(19220..20545)
                     /locus_tag="C2142_RS30535"
                     /old_locus_tag="C2142_30565"
     CDS             complement(19220..20545)
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978685.1"
                     /locus_tag="C2142_RS30535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_30565"
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_148646066.1"
                     /transl_table=11
                     /translation="MTVSVALFTQDLRLYDNPVLHAARAAADQVVPVFVLDPAVEAAGF
                     STPNRQAFLADCLADLDASLRRIGSRLVVRHGDAAEQTARLAEETGAVSVHVGAGVSAF
                     AQRREAGLRARLGDRLHVHDAVLTVVPAGRVTPAGKDHYAVFTPYHRAWQRVPRRAVMP
                     APRSLDTPPAVRGEDLPTARAVSPALPPGGETAGRARWRKWDVDAYADVHDALADDGTS
                     RLSPYLHFGCLSATELAVRALERGGEGAEAFVRQLAWRDFHHQVLAARPDAAHRDYRTR
                     HDHWQHDEREAEAWRQGRTGYPIVDAGMRQLAHEGWMHNRARLLTACFLAKSLHLDWRI
                     GARHFLSLLVDGDVANNQLNWQWVAGTGTDTRPNRVLNPLLQADRYDPDGAYVRRWVPE
                     LGHVQGRAVHRPWLLADRPDYPDPIIAPDMLADRLRHARGLD"
     misc_feature    20953..20965
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.78"
                     /tool="antismash"
ORIGIN
        1 ggtcgatgac gcgcacgtcg agcggcggcc caccctcctg cggcacgtga taccaccggg
       61 tgccgtccgg ggcgtcggtc acgtggcgga tgccgttcgg ccggaatccg gccgagccca
      121 gggcttccag catccgcccg acggcggtct gcggcccggg ccccccgagt acgcggcggg
      181 taccgaggac gatggtccgg cccgccgcca cggccgggcc gccgaccgtg gaccggagca
      241 ggacgacgcc ccggccgagc atgcggagca gcaggcgcac caggtccgac agccggcgag
      301 cccgcgtcgc gtgtgacggc tccccgggcc ctgtccggcg gcccggccac atcgtcagac
      361 cctcgtcacg gttaccgcgc atccgccgca tcgtcaaagg aggcctctca ctggacggtt
      421 cagcgcatta tcccgccgga ccgtcgtcgg agatcacccc catggcggaa cccgcggtcg
      481 ggcggtcaac ccgggcgacg gtccgggccg gtcagccgag cccggccacc ggaccgagat
      541 gacgccgtag cgcgtcccgg atcggcggca ggatgggcag gcccgccagg tccgagaacg
      601 gaatccaggc agacgcgtcg acacccccgt gcccgccgtg cgtcagctcg cccccggtca
      661 cctcgatctc gtaaagggcg aagacggcat ggaagtcgat gccgatgctc agcaggcggt
      721 gttcggcgtc gaggtccagc agccggcccg cggcaacgtc gaacccggtc tcctccttga
      781 actcgcgcac cacggtgtcc cgcgggtgct cgccgtgctc gaccttgccg cccggaagca
      841 tccagcgacc gtggtcgtcc ttggaggacg gcccgatgcg caccatcagc accgcgtccg
      901 gccgccgcag gatcccgtac gaagcgaacc gttgcaacgg ctcgtacgcg gtcgtcatac
      961 cggtccgtcc tcccacatcc atacgccggg gcccgtcctg gagctcatgc ccagtgccgc
     1021 cggtccttgt ccattgtgaa ccgccagagc gccagcgccg tgaaggccgc tgcgaagccg
     1081 agcagcgccc cggcgttcgg cagcacgccg cccactccgg cgccgtccag caccaccttc
     1141 cggaaaccgc cgaccgccca gtacaccggg gtgaacctgg cgatccagcc gatccagtcg
     1201 gccatcagct cggtcggcac cagagcgccg ccgaagaccg tccagctcag cgtgaccatc
     1261 cgctcgaccg cgaacgcctg ccgccgggtc ggggagaccg cgcacagggc cagcgcgaag
     1321 gagaccacac agacggccag cgcgaccatc accacgagca gcgcgagcag cgaaccgtgg
     1381 acccgcaggc cgatcaccgc ccagcccagc acgaacagga acacgcactg gccgaccacg
     1441 agggccgcgc acagcgcggc cttgcccacc agcagctccc aggtgcgcag gggcgacaga
     1501 cgcagccgct gccaggtgtg caggccgtgc tcgcggaagt aggactcggt gaccagcccg
     1561 gtcatgaaga acgagaacat gcccgtcatg ccgggcaccg ccagctgggc gccgtcggcg
     1621 tcgccgtagc cgagctggga gagcgcaccg gagtacagcg gcttgatgaa cagcatcagc
     1681 agacagggcg tcagcagcac cgtcacgagc ggtgccggct cacggcggag ccaggtcgcg
     1741 tcatgccgga gcagtgacag gactcgtgtc atgcgatgcc tcccccgcca ggatgttgaa
     1801 gtacgcgcgc tcgagatccg cccgggcgat ctccactccc tgaagccgct cccggtggcc
     1861 ggccacagct tcgagcgctt tgacgatgtc gaccgcgggc cgcgcggtcg ggaggaagac
     1921 ggtgtcggcc aacacccgcg cccccggcca gatgatctcc ggtggctcgc cgtcgaagcg
     1981 gagggcgagt tcgctgcggg tgttctcggc gatcagcccg tccacagtgc cgtccgcgac
     2041 gatccgcccg ccggcaagca ccaccacccg ggcgcgcaac tcctcgacct ccgccaggta
     2101 gtgcgtcgtg tacaccacga gcgtgccgcg cgcagcctgc cgttgcacga cctccagcag
     2161 ccggagccgg gtctgcggat ccgcgcctgc cgtcggctcg tcaagcagca cgacctcggg
     2221 ccggtgcacc agcgcgcagc cggcgtgcag ccggcgctgc tggccgccgg agagctccgc
     2281 cgcgcgctgg ccgcgctgac cggtgagctc cagcgcgtcg atcagcccgt cgacggactc
     2341 ggtcagttcc cgtccccgca gcccgccgag cgagccgaag aagcgcaggt tctcctcgac
     2401 cgtgtgcacc gggtagaccg cgatctcctg cccggcgaga ccgaggcggc ctcgcagcgc
     2461 cttggccccg ccggccacat cggtcccgag cacctgcacg gaccctccgt cggggcggag
     2521 cagaccagcg atgacggaca tcagcgtggt cttccccgct ccgttcggac cgagcactgc
     2581 cagcacctcg ccgcgatcgg cggagagcgt cagtccgcgc agcacgtgcc gctcgccgaa
     2641 ggacttctgc agcccctcga tctccagacc aggtcccact agtcggcacg ccgcccgagc
     2701 gacaccagca tgtccgagga gttcttctcg atggcccgga ccgcgaccgg ctccagcatc
     2761 ggccggagca tcgggatgcc gatctcgaag tccacctcaa gggtggcctc ggtgatctcc
     2821 tccgtcacct tcgtcacctg ccagaacccg gcgaaccgct cgaggtcacc ggccacctgc
     2881 tcataggtca gacgccactg cgacgggtcc cggacctcac gctcgctcca cttgagcacg
     2941 gaccccttga gcaggacctc ccactcggtc accgcctcgg tgatcccgtc gggccgggtc
     3001 tcctcggaga gcacctgggt cctgatcacc gagtccatga aggtggggta ggactcgatg
     3061 tcacagattc gcttccacac gtcgtcggcc gaagcgacca gtcgttcacg caccgttacg
     3121 atcggcaatt tcttccatct cccctgtatc agtccagttc gagctgagtc cgccgggcgg
     3181 cggcgttcag cttttccgcc acgaatgcca gatcctgcgc cccgatgaag gccgccgggg
     3241 tgagccgcag gatcgacggc gccgtcaggc acggtgtcag cagcaggttt tccgccagag
     3301 cggcccgcat catctccccg gccacgtccg gctgggtgcc gtgaagcccg agcagcgcgc
     3361 cccggccggt gacctcggtg aacagccggg gccaggaccg gaccaggtct tcgaggatct
     3421 cccgcagccg cccgcccgcg ctccgggcca gccctggaac gtcctcggcg gccaagacct
     3481 tcaaggtggc cgtgagcgcc gccgcggcca gcgggttacc cccgaaggtg gaggtgtgca
     3541 gcagcgggtc ccggtcgtac ggctggaacg cgtcctcggt ggcgatcacc gccgacaccg
     3601 ggatgacccc gccaccgagg gccttccccg acagcaggac gtccgggcgg acgcccagat
     3661 cctcatgggc ccagaacgag ccgcaccgcc ccaggccgca ctggatctcg tcgaagacca
     3721 gcagcgtacc cgcctcgtcg caggcctcgc gcagggccgt cgcatagccg ggcgtcagcg
     3781 ggtagacacc gccctcgccc tgcaccggct ccgcgaagac cgcggccggg cggtgcctgc
     3841 ggatcagctc cgcggcggcg ccggcgtcgt cccgcggcag ccggatcacg tcggggagca
     3901 gtgggcccag gcggtcgcgg aacaacgcgg catcggtcag gctcagcgca cccacggtct
     3961 tgccgtggaa cgagccggcc agatgcgcca gtggtacgcg tccggtacgg gcccgggcga
     4021 gcttgatcgc tgcctcgacc gcctcggcgc ccgagttgag cagcatcacc ttgtccagcc
     4081 ccggcggggc gaactccgcc agatcggctg cggcccgggc gttgagctcg ttgggcagcg
     4141 tccgggtcga gcccgacagg cgggccagtt gctccgccac ggcctcgacc acctgggggt
     4201 ggctgtggcc gagcaggaag acggagaacg agccgaggtc gaggtagcgc gcgccggcgc
     4261 cggtggtcac ccaggagcca ctgccggaca cctcgggatc cgtcgcgccc atcagcctga
     4321 acaacagcgc ccgcccggac gactggtggt cgcgaatgag gtcgagcaga tccatcagga
     4381 ggctccttcg gtgggctgct ccgagagctc gaagctccag ggcaggccga gcgcccagcg
     4441 tccgagcagt tgccgggtgg cgaaccgggt gggcgggtgg aagcgggccg cctggacgtc
     4501 ccggatcagc cgcgaggccg ggcccgtcgc ggagtacgaa gcgacgccga ccagctccgc
     4561 ggccagctcc accgcgcgca cggccatctg cgcggcctgg tccttgaggg ccagcatggc
     4621 cggcaccagg cttcgcgggt ccgtccgccg ctcgtccagc tgccgggcga gtccggcggt
     4681 ggcggcctcc agcggcagcg ccgcggagat gatctcgccg agggcggact ggaacgaggg
     4741 cagctgggac cgcgtcgcgc caaggtggtt gatccgcgac cggccgagcg cggcacgtgc
     4801 ctggtcgacc gcggccgaga cgacgccgag gtagcaggcg gtggcggtga cgcagaacca
     4861 gcccagcccc gcggcgaaga cctcgtcacc gagcgagccg ggctcgctgc gatggaagac
     4921 caagtcgtcg gggatctcgc agtcggtgaa ccgtaccgtg tcggactcgg aggcgcgcat
     4981 gccgagggtg ttccaggtgc gctccacggc gatcccggga ctgccgttca ccaccagagc
     5041 caccagcagg ctctccggcc cgccggcctc gtcgatcatc tggaggcaga gcaggtcgct
     5101 gcgctccgcc agcgagcacg gcaccttgag gccgttggtg atccaattgt cgccgacccg
     5161 gcgggcgacg gtgttggacc tggtcaggct gccgttgagg cccggctcgg cgaaggccga
     5221 ggcgacgatg cggttctgac tggcgatggc ctccaggagc agccacgact cgtcgcgttc
     5281 ccggtaccag tgctcgacca ccaccccgac cgagaacagg tgcatgttca ccgcgaccgc
     5341 cagcgccggg tcggccgcgc cgatccggcg ctgcagcgcg cagcattcgg tgatcgacgc
     5401 cccgccgccc tcgaagtcct tcggtacggg cgcgccgaag tagccgttct cccggagcag
     5461 ttcgatgctg cggtcggcaa gccgaccggt caggtcgttc tgctcggcga gggcggccag
     5521 ctcggtcgtg gcccgttccg gcagcaggtg ctcggtgtcc ggccagagcg cgccgatgcc
     5581 gttccggtag tcgtaggcgt cgttcatgcc gccccctcct cgccgaccca aggccgcggc
     5641 gagctcttcg ccaggtgcgg acgccggtcg gcccaggccg cgatcgcggt ttcgatggcg
     5701 ccggccggat cgtcgacctg ccagttcacc ccgatcggct cgcccaccga catgtagggg
     5761 atgaactcgc cgagcaggtc gatctgcctc agctgacgat ttgtcagatg cggtttggcg
     5821 aagggcaggt agaagcgatc ccactggtcc ggtgtgacga acccgggggt ctccagcggc
     5881 tcgtacccgt gggacgcccg ccagcggttc agcgacaggt acatggagtc gaccacgccc
     5941 ttgagcggca gcacctgctc gcccgccccg agcaccaccg gctcggccct cggcccggtc
     6001 tccgcgatct ccagcacgca ggtggcgatg tcgcaggtcg agacgacctc caccggggcg
     6061 tccacctcgc cgatgaagac gggcagcatg ccggtcacgc cggactgcat caccgagtac
     6121 aggccggtgt gccggctcac agccccgtcc gagcgccggc cgaccaccag tggtgggcgc
     6181 acgatggtcg ccccgtaccg gctggtggcc tcgcgctccg cctcggcctt ggaccactcg
     6241 taggtgttgc ggtagtcggc gaggtcggag gaccgcgtgt tgccgcgcag gccggtcgca
     6301 taggcggtgg agacgtggat gacgtgggtc gcctgcccca ccagcggctc cagcgcggcc
     6361 accggcgcga cgttggagtc cttcgcctcc tgggccggaa ggttccagcg cggccgtgcc
     6421 gccgcgtgca cgatcacgtc ccagggcccg gccagctgct ccggggccgg cgcctcgccc
     6481 atacgccagg cgacggcgtc cgcggcgccc ctggccgagc tggcggtgac gtgccagccg
     6541 gcggccctgg cgcgttccac gatctcgacg cccaccaccc cggtggcacc ggtgaccagc
     6601 atggttcctg gcctgttcac agcggcttgg tccattcggt aggaagcaac gggggaaggc
     6661 cgagctggtc ggcaagtgcg tgccagcccc ggaccagccg cagcgcaccg aacatgcctt
     6721 ccggcgagcg gagttgcggc agaggatcgg ccagtccgag ggtcgcctcg atctccgaga
     6781 cccaggatcg gacccgcctc agccagtcac cggcgcgctc ctcggagggg gcggccgcgg
     6841 cgaactcgcg ggcttcgctg atcagtcggt ggccggactc ccagtcggcc gccggcacat
     6901 gcgtgtacgg atcgatcgcc ccgccgtcct cggcgacata gggctcggcc cctgatcgca
     6961 ggccgccggc ctggcagcaa accatcacca gatagcgggt ctgggcgagg acaaggtgcc
     7021 actgaccggc cggaacccca ccctcgatgt cctccagcgc cgactgggcg ccgaccatga
     7081 tcagcagcgc gccgtggctg acctgggcca cttgccggtg caggctgtcg ttcgtccgaa
     7141 ccgtcatacg gggcactcca ctcccagcca gagcaggtcc tcgacgaaga gcgcagccac
     7201 gtccgggtgc cactcctcgt ccagggcaaa ggtccacgtc ttcgcgtggt cgaccgggcc
     7261 accagcgggc accgacagcg tacgaaggcc ccagcgcgtg accagtcggc tctcgccgaa
     7321 ctcgtactgc tcggttccgc gcgcgtggct cagcctgacc cgccaggccg agccgtccac
     7381 gtcccgcgcg tagtggtcga gcagctcgcc gacctgggcc aggtaggccg gcaccttgtc
     7441 cggggaggcc ggcgggcaca tcgccagctc gaacgccgcg agcccgtcgc ggtcgtcgag
     7501 cttgcgcagc ttctcaccca gccacttcgg cttgaagtac cgctcaccgc gctcgaccgc
     7561 ccgccgctcc agggcggcgg cgagggcctc gccgatccgc agcgccgcca ccatgggctt
     7621 gcgctcggcg aacacccggg cggcgatccg cttgcgaacc gcctccgccg cgtaccagga
     7681 actgatccag ccggacagct cggcgtcgag ccgccgctgc caggaggacc actcaggcgt
     7741 gccggtgagc agcagtccga ggccgaaccg gcttacgctg tcgaggacct gacgcctcgt
     7801 cccgagatcc cccggcccga tctcggcggg cggccagtgg gtcgtggtca gctcctcgta
     7861 ccgcttggtg acctggccgg ccccgtgcag tacgacatcg atccgagacc cctccggata
     7921 ggacatcagc ggaagggtgc tggccacctc gtccggcact atcgcataga gatccaagtc
     7981 actgttggca ttgccgaatc cggcgatcac cgaaccggca gccgtgatca ggagcggctc
     8041 tccgaatgag ctgtccacct gttccagtat ctgatctggc gtcagattac tgcgagaaag
     8101 gtgcgcgtga aaccgctcgg tcagcgcggc gtttgccggc gacccctgta tggccatcaa
     8161 ggcccccacc ctcaatcccc cgtgcgtgct gctcaaaacc cagccgtcta cggcggctac
     8221 cgtcccacac cgccacaatg acagtcaatc acattacgtg accaaccagg gctttgccat
     8281 gatcaacccg gttgtgcatg gccatgcatc gaatgtgtcc agaaggtgac aagctcacag
     8341 atcccacact tctacccccc caacggcacg catgagaagc cacccggcac acccggacag
     8401 ccgcaaggca catccgggtt gacagatgcg cacccggcta tgaaacatgc agtgaagcgc
     8461 gtacgtggac cagccggaga gcagtgccgc ggcctgatca agcctcgggg acatcgctac
     8521 tctccgctta tgcaccgcgt cctgacggcg cttcagactc gtgatctaac gggtttccat
     8581 gggggaaatc gagtggagct tcagtccaac ctgtccggaa tcgattcgga cgcaacatcg
     8641 ccgccttcgg cggaacagat catgctggag ttggtggacc cacagggcgt caccgtcggg
     8701 atctccgaga agatcgcggc gcacgaatcg ccgggccgtc tccatcgggc gttctcggta
     8761 tttctcttcg acgacgaagg acgcatgctc ctgcagcagc gcgcgctgtc gaaataccac
     8821 ttccccggcg tgtggtcgaa tgcctgctgc gggcaccccc ttccgggaga ggcgccgttc
     8881 caggcggccg tccggcgggt cggggaggag ctgggcatcg ccccggcgct cctgatggag
     8941 gccggcaccg tcacataccg acacccggac ccgcagtccg ggctggtcga gcacgagtac
     9001 aaccatctct tcgtcggcct ggtcagggcc gagccgcggc ctgacccgga cgaggtggcc
     9061 ggattcgccc tggtgacccc ggatgagctt cgcgagcgcc gggcggtcga caccttctcg
     9121 ggctggtttc aggacgtcct ggaggccgcc ctgcccgcgg tgaagcgcct ggacgccgac
     9181 atccactggt gacgaacgat cagatccgca gtcccggaga ccgtccgaga ggaactggaa
     9241 tgccgacaag cgtggccgat cagcactggc tcggcaccga ggtggacatc gactggaccg
     9301 atctcaggtc ggcccacgcc caatgccggt ccgtactgcg ccggctggcc gccgacagct
     9361 ccctgctgac ccacctggtc gaccggctcg ccgacgacaa ggacctgctc gcggacgccg
     9421 accaccaccc ggtaatggac cggctgaccc tctggcacga tcccgaccgc ggcatctacc
     9481 tgcgcctgca cgtgtcgccc ggtaccaacg agctcatccc gcacgaccac aagtactcgt
     9541 tcaccactta catcctgcgt ggctcctaca cccacgtgtg gcgtcggcgc gagggcagct
     9601 accagggcga cttcacctcg gaccaggctc cgctcgggct ggtgaccagc gagcgggtcg
     9661 gatcctgcta caccctcggg tactcgctca tccaccagac ggtgatggaa gccggcacag
     9721 tgacgctctt catgcgtggc ccgaaggaac aggcgcggtc ctacgccgct ctcgacatgc
     9781 tcgaccgcct caccgtcgat gcggcgaccg aaccggtcgc gtcggagcag cgccggcaca
     9841 ccgacggcga gcgcggcctg ggattcgacg agtacctccg gctgcgggac cggctgtcgg
     9901 cccagggcgt cctcgaaccg tccgtctccc ccaccgatat caccacgacc caccccgaga
     9961 ggcgcccgtc ttgaccgaca tcgacaccgt gacccgcgag atgcaggatc ggatcgcgta
    10021 ctaccagcgc cacttcagcg atctcttcgg ccggtacttc gaggatctcc gcaacgactt
    10081 cgacggcccg gagctcagcc gcttcacccc gcgctgcctc gacctgctgc aggagctctc
    10141 actgcgcggc ggcaagcgcc agcgtgtggc gttcatgtac gaggcggccc gactggtcac
    10201 cggcgagcac ctcccggggc tcgacgaagc ggcgttgagc atcgagctgc tgcagaccca
    10261 cctgctggtg cacgacgaca tcatcgacga cgcgcccacc cggcgtggcg ggccctccac
    10321 gtactacgcc taccgcgcgg agttccccga ccagccgcag accgcgctcg gcctggcact
    10381 gctcgcgggt gacctggcgg ccttcctctc actccaggtc ctgctcgacg cggaccttcc
    10441 cctggccctc cggaccggca tggtggacct gcagacgcgc gccgccgccg ccaccttcgt
    10501 cggccagatc ttcgacctcg agcgggactt ccccggcatt ccgagcgagg agatgctcca
    10561 ctccgtctcc gactacaagg cctccaggtc ctccgccctg gccccggtgc agctcggcct
    10621 gctggtcgcg ggtgaggacc cggcccagca cgcggagacc ctcagccggt acgcactcat
    10681 gttcggcatc tccgggcaga tgtgcgacga ctacctcagc ctcttcggcg acgaggcggt
    10741 caccggcaag cccaacaccg cggacatccg cgacggccga cgcacctacg ccgtccgcgc
    10801 tctgctggcg gctgcgtcgg agacggagcg cgccgtggtc gagtccgtgc tcggcagccc
    10861 cgactgcacc aacgaggacg tcaacaagct ccgggagatc gcctcgcgcc acggcgtgga
    10921 ccgtcagctg cgctcggaca tgcaccggta cgccgagctg gcgtgcaagg aggcagccgg
    10981 ctggcgcccc cgctggcggg aggaggccgt cgccttcttc gagcgcgtcc ccgtgtgggg
    11041 tgtggagcgg acgctttgac ctcgaccacc gattccgcga ccgccggttc cctgatcggc
    11101 aggcccgggg ccgccggtcc ctcgcacgcc gtgggcgggg gcgcggtgcc caggcatctg
    11161 ggtctgatcc tcgacggaaa ccggcgctgg gccagggccc gcggccgttc cgcctccgac
    11221 ggccaccggg ccgggttctc ccggatcccg gaggtcctgc ggtggtgcga gagcctcggc
    11281 gtcgaggtgg tgacgctctg gatgctctcc accgacaacc tgagccggga cccggccgag
    11341 gtggacgcac tggtcagcat catcgccgac acggtggacg gcctcaccgc gcacggcggc
    11401 tggcgaatcc ggcatctcgg agtccgctcc gccgtccgcc agccgctgct cgacgccctc
    11461 gaccgggcgg tcgccgacac ccgcggggtc gccggcctcc aggtcaacct ggccgtgtgc
    11521 tacgggggcc gcgaggagat catcgacgcc tgccggagcc tccttgagca gtaccgggca
    11581 gaaggactct cgacctccga ggcggctgag aaactcagcg tcgagacgat ctcggacatc
    11641 atcagcgccg gcgcacccga gcccgacctg atcatccgta cgtccggcga acagcgcacc
    11701 tcgggcttca tgctgtggtc cgggatgtac accgactact ggttcacccc catctactgg
    11761 ccggacttcg atcaggcggc tctcgacgag gcgctcgcgc actaccggcg gtcactctcc
    11821 gggcggctgc ccgcgagagt ggggtgaccg agcatggaga ggaccgaatc caccatggcc
    11881 ccgaagccaa tctcccgggg ctgcgccatc gggctcatcg gcatcgacgg cgtcgggaag
    11941 accacgctcg ccggtgagct ggaacgacgc ctgaccgagc gcggggtgcc ggccgtgctg
    12001 ctgtcccggc ggcagtacct caagacgcgc ccgcacgact tcgtcggcga cacgatggcg
    12061 acgctctacg agggatccct gcggaccctc tacggcttcg ccggtctcgc cggtggcggc
    12121 acgctgggcg accacttccc gccaccggcg ggcccggtca tgtccgccga cttcgaacgg
    12181 ctcctggacg gcgccgcgat caccggcaac gacccgcacg cgctgatcac gtccatgctc
    12241 tgcgagatcg ccggtcatct ggcgttccgg gaggccgtgg tggcccccgc ggtacgcgcc
    12301 gggaaggtcg tcatcgagga cacccacggc atcaagatgg tggtgaagct ctatctgctc
    12361 gccacctccc tcgcaggctc cggcgacctg tcgaaccaga gcctggaggc ggtgctgaag
    12421 gccgggatca ccgcgctgcg gcccgatccc gcggcctccg taccggtgct ggtccaggtc
    12481 gatcccgaga tcgcctacca gcgccgggtg gcccagcacg gccgcgtggg agggatggag
    12541 cactacggcc cggtgggccg tgccgtcgga cacgactcgt acgtcgagct gcagagccgc
    12601 agccagaaga tcttcgacga gataggcacg ctctggggct gcctgcgagt ggaacttccg
    12661 ccgcaggacc gggagggcgg cctccggaca gcggtggacc agatactcgc ggccgtggac
    12721 ggcctggcgg aagggcagta agcagtgaca gaccaactcg cgatcggtct cggaccgcat
    12781 tggatagacc acctgccggc gctcgactgg acaaacctgc gcgccgggca ccgccaggcc
    12841 cgctccgtgc tgacccgact ggccggggac cgggagctgc tgactcgcct ggtccacgag
    12901 atcgagcacg acgaacagcg gatgaccgcc agcgagatcc acccgctgat caaccggctg
    12961 atcctctacc aggacgacgc ccgcggcttc cagatccggc tgcacatgtc gccgggctcg
    13021 cgtgaactcg tcccgcacga ccacaagtac acgttcaccg cctatgtact gcagggcgcg
    13081 tacgtgcacg tctggcggcg ccgggccgac cgcggggaag gggagttcac cggggacgac
    13141 atccgacccg gaatcgtctc gatcgaacgc cccgggacct gctacacctt cgggcacccg
    13201 ctgatccatc agaccatcat ggtgccgggc acggtgacgc tgttcatgcg cgggccacgg
    13261 gtcaagcagc gttcgcacgc ggccctggac atgctgccgc aggcggacaa ctggccgccg
    13321 ccgtccgagc tcggcaagcc caagcacgcc aacggtcaac ggccggtcac cctcgacgag
    13381 taccgcgcga tgcgcgccca gctcgtcgac agcgggctga tcgacgtcat atccgcctca
    13441 gggtcgaccg gatgacgcca cgccatgtcg gggtgatcct ggacgacggc gcgaacaggg
    13501 ccggaaccga cggcccaccc gaggccgagg cgtaccggcg cagctgcctc aagcagcttg
    13561 agatcgtcga gtggtgccgg gcggagggag tgtccgaggt caccctctac attccgccgc
    13621 caacgtcccc gctcgccgac gaggagctgg aagccgtctg gggcgaggtg ctcgaccaac
    13681 tgcggcagga ccgggccggc atcgcaccgg tgacgcttca ccaccttggc gatccggccc
    13741 tgctgccggc cgccctggcg gccaggctgc ccggccgcac cgggccggac tcccggaacg
    13801 gccacgggtt caccgtgaac ctggtgctgg gctacgaggg ccgcaacgag atccgcgacg
    13861 cggtgagctc gatcctcgta gccgcgcagg acgagagcag gagcctggcg gaggccatct
    13921 ccggcctgga cgccgagcag ttgggcgccc acctgctcac cggaaccctg ccgccgatcg
    13981 atctggtgat ccggaccgcc ggccggcggc acctggccgg gttcctgccc tggcaggccg
    14041 cctacgcgga gttccacttc acgacggctt ccgcgtccga gttcgcccgg ggcgacctga
    14101 ccgtggcgct ggcggactac tcacgcagga atcgcaggtt cggcaagtga tgggagtgat
    14161 gatggagacg cacgacgcgg agtcgttcga tctggctgct gcgtgctcgg agatcgactg
    14221 ggacgatcca cgtcggtcaa gccggcagac ccggaagctg ttgggccggc tggccgccga
    14281 ccgcgagctg ctgacggatc tcctggtggg catcgagtcc gatccgctgc ggctcggccg
    14341 ttcggagcgc cacccgctga tgcaccggct ctcgctgtac gaggacccgg agcgccgctg
    14401 ccagctgcgc ctgcacttct tcaccggccg cgaccgggac ctggtgccgc acgaccacaa
    14461 gtacccgttc agcgtccacg tgctgtccgg cggctacctg cacgtctgga accggcggac
    14521 cgacgaggcg cagatcggcg acttcacctc ggaggacgtc acccccggca tcgtgacact
    14581 ggagcgtcct ggcacgagct acagcttcca gaactcgctc gtgcaccaga ccatcgtgct
    14641 gccgggcacg gtctcgctct tcctccgcgg tcccaagcgg caggaccgct ggcatgccgc
    14701 caaggacatg ctccaccttc tcaacggcta cgaggcaccc agcgagggca agaagaccca
    14761 cctgggcgcg gagccgatca ccaccgatga gttcctcgtc atccgggacg acctggcgcg
    14821 acgcgggatc attaccgaca ggaggccctc aggtgtcgct gcctgacttc ttcatccagc
    14881 ccgtcgtgca gttgctggca cagaccgcgt cgccctacga cgtgccggcg gatcccgaga
    14941 tcttcaacga gaactggctg gagcccaccc tgacccggac gctcgcgcta ctgcgcgagg
    15001 ccgacccgga gaagctcgcc gcaacatcgg tcaccggcag cgggctcacc tacctctcgc
    15061 tcgcatcgga cgtggagaag gactactcgg tccacctccg tatcgccggc gaaggcaagc
    15121 cggtgccgcg cgacccggcc gagaaggccg tggtgctgac cctgggcggc acgatggagc
    15181 tggaggccta ccggcacggc ggggacgtcg aatcggacac gccctggtac gtccggcagt
    15241 tcaccccgga gaacatctac gcctgccacc cggggacgct ccactcggtg gagcagtccg
    15301 aggacgcggt ccagctcgtc atctccaggg gcgaggcacc cgcgatcggc cgcccgctcg
    15361 acgccgacga ataccgcctc gccgccgagc gcacccggca gctgctcgac cgggttctcg
    15421 agagccggcg caccgagact gcgcagatcg cctcctgacc ggggctcctg gaaggacccg
    15481 gcggtgatgg ggcggggccg cggccccgcc ccatcaccgc cgtccggctg tcgtccgggc
    15541 cgtccgcggc cactccgacg ccaccgcgtt ggcccttcgc cgcggagcag tcctcgttca
    15601 gttccgctcc ggtcgagttc cgggtcgagt accgccccgg tcggtgtcac gggcaggact
    15661 ggccgggtcc ccggcacgca cgagacatga catgccgtca tgccgggcac gacccgtgga
    15721 tccgcatacg caacattcgg aatcatctga aacgaggagg aacgggtggc cctgctgacc
    15781 cgcattcggg gaccgcgcga tctcgacaag ctcacgcccg gacagctggc caccctggcc
    15841 gaggagatcc ggaccttcct ggtgacggag gtctccaaga cgggcggcca cctcggcccg
    15901 aacctcggcg tcgtggagct gaccgtcgcg ctgcaccggg cgttcgactc gccgcgcgac
    15961 cgcatcctct tcgacaccgg ccaccagagc tacgtgcaca agctgctcac cggccgccag
    16021 gacttctccc ggctcaagat gaagggcggc ctctccggct acccgtcccg ggccgagtcc
    16081 gagcacgacg tgatcgagaa ctcgcacgcc tccaccgtgc tctcctacgc ggacggcctg
    16141 gccaaggcca accggatcca gggcaggaac gacccggtcg tggccgtgat cggcgacggc
    16201 gcgctcaccg gcggcatggc ctgggaggcg ctcaacaaca tcgccgacgc caaggacctg
    16261 ccggtcgtca tcgtcgtcaa cgacaacgag cgctcctact cgccgaccat cggcggcctg
    16321 gccaaccacc tcgcgacgct gcgcaccacc cagggctacg agcgcttcct gtcctggggc
    16381 aaggacgcgc tgcagcgcac cccggtggtc ggccagcagc tgttcgagac cctgcacggc
    16441 gccaagaagg gcctcaagga cttcatcgcc ccgcagggca tgttcgagga cctcggcctc
    16501 aagtacatcg gcccgatcga cggccacgac ctcaccgcgc tggagtcggc gttcaccaag
    16561 gcgcgcggct tcggcgggcc ggtgatcgtg cactgcctga ccgagaaggg ccgcggctac
    16621 cacgccgccg agaacaacga ggaggaccgc ttccacgcgg tcggcgtgat ccacccggac
    16681 accggcctgc cggtcaagag ctcgggcaag gactggacgt ccgtcttcgg cgaggagatg
    16741 gtcgcgctcg gccacgaacg cgaggacatc gtcgccatca ccgccgcgat gctccacccc
    16801 gtcggcctgg ccccgttcgc gaaggccttc cccgaccgca tcttcgacgt cggcatcgcc
    16861 gagcagcacg ccgtcaccag cgcggccggc ctggccacca acgggctgca cccggtcttc
    16921 gcggtctacg cgaccttcct gaaccgcgcc ttcgaccagg tcctgatgga cgtcgccctc
    16981 caccggctcg gggtcacgtt cgtcctggac cgggccggtg tcaccggcac cgacggcgcc
    17041 tcgcacaacg gcatgtggga catgtcgatc ctccaggtcg tccccggcct gcgactggcc
    17101 gccccgcgcg acgccgacca ggtgcgcgcc cagctgcgcg aggccgtcga ggtcaaggac
    17161 gcccccacgg tggtccgcta ctccaagggc acggtcggcc ccgccgtcgc cgcggtgggc
    17221 cggatcggcg gcatggacgt gctgcgggag gcccccgggg ccgcggagcg ggccgacggc
    17281 cgccgcgccg acgtgctgat cgtctcggtc ggtgcgatgg cccccaccag cctggaggtg
    17341 gccgacctgc tggccgccca gggcatcacc gccaccgtgg tggacccgcg ctgggtcaag
    17401 ccggtggacg aggccctgcc gggcctggcc gccgggcacc gggcggtcgt cacgatcgag
    17461 gacaacggcc gggtcggcgg cgtcggcgcc gcggtcgcgc aggcgctgcg cgacgccgag
    17521 gtggacgtcc cgctgcgcga cttcggcatc ccgcaggagt tcctggacca cgcctcgcgg
    17581 ggcgagatcc tcgccgagat cggcctcaac gccccggaca tcgcccgcca ggtgaccgcg
    17641 ctggtcgccc ggctcgccaa gctggacgtg gccaccgtcg aggcctgaga ccccgtcggc
    17701 tgttcccggg ccgggactgt ggagctcctg gcccgggcgg agcggtgagg acgggcgggg
    17761 acgccttccg ggtggcaccg cccgagccgg tcaccgcgac cgggggcggt tcgtcgtcgg
    17821 ggtctgcgcc gcggatgggt gaggtacggc cttcgaggcg gacaagtccc agggcctgct
    17881 tcatcttccg gtagtcgtgc tcgatgcgtc ggcggagctt ggcgaggcgg accaggggac
    17941 tccacgggct ggaggtgacg aagtgtgcca gggcctgccg gttgccgtcc tcgcccggcc
    18001 ggggccgtca tcggctccac cgactcgcgc cggcggaagg acgacgggga gcgggcccga
    18061 ggacggcaga gggccagtgg aaggccggcg gaaggtcgat ggaaggctgg tggaaggctg
    18121 gtggagagac cgtgggaggc cggtaggagg ctgaaccagt cgtccgctcc cgtccgtcat
    18181 ctcctggaga accgttcact cgtccggtcc cccgtacagg agtcatcccg ccaccatgtc
    18241 cacccaggcc ccagctcttc gccgcccgga agccaccgtc caccgaaggc ccccggtgcc
    18301 gctgcccgcc gcccaccgga gaacccgccg gccggaggcc cggcctgctg tggggagtgg
    18361 ccggtgaggg gcttcggcgg atcccggcgg agggtctgga caggcgcgct cgccggggtg
    18421 gtaaccgccg ccctggtcgc cggcctgctc tggtggcacc cgtggacccc ggccgcgacc
    18481 ggccggcaga agccgatgga gttcaccacg gccggcggtg gctccccccg cttcggcacc
    18541 ggcgagaagc tctaccgcta caaggtgcgc gccgagaacg ggatcaagga gacccccgac
    18601 cagttcgccg ccgaggtcga cgcggtcctc ggcaacgtcc ggctcggctg ggccgcggac
    18661 ggcacccggt ccttccagcg catgcccgcc gacccggtgg acttcaccgt ctacctggcc
    18721 accccggaga ccaccgaccg gatatgcggc cagtacgggc tggacacggg cggctgggtg
    18781 aactgcggcg tgggccacca ggtggtcatc aacctcaagc gctggaacga gctcacggag
    18841 ttctacagcg gccggcccga gctctatcac gcgctcgccg tcaaccacga ggtcggccac
    18901 gtcctcggcc tcgggcacgt cgactgcccc ggtccgggcc tgccggcgcc cgtgatgatg
    18961 cagcagatca aggggctgca cggctgcgta ccgaacggct ggccgtactc cgagaccggc
    19021 accctcctca ccggtcccgc cgtcgaggcc gccacccccg ccccgtagcc gcgcaagcgg
    19081 gccggccgcc gtacacgtgg gcggcggccg gccccgcccg gcccggaagc cagggtcggc
    19141 ccgggcgggg ccgggtgggc ccgggcgggg ccaggccggg tgggctgggc ccgggccggg
    19201 ccgggcgggg cgggtggggt cagtccaggc cgcgcgcgtg ccgcaggcgg tcggcgagca
    19261 tgtccggcgc gatgatcggg tccgggtagt cggggcggtc ggcgagcagc cagggccggt
    19321 gcacggcccg gccctgcacg tggccgagct ccggcaccca gcgtcgcacg tacgcgccgt
    19381 ccgggtcgta acggtccgcc tggagcagcg ggttgaggac ccggttcggg cgggtgtccg
    19441 tcccggtgcc ggccacccac tgccagttga gctggttgtt cgccacgtca ccgtccacca
    19501 gcaggctcag gaagtgccgc gcgccgatcc gccagtccag gtggagcgac ttggcgagga
    19561 aacaggccgt caggagcctc gcccggttgt gcatccagcc ctcgtgcgcg agctgtcgca
    19621 tgccggcgtc gacgatcggg tagccggtgc gcccctgccg ccaggcctcg gcctcacgct
    19681 cgtcgtgctg ccagtggtcg tgccgggtgc ggtagtcccg gtgcgccgcg tcgggccggg
    19741 cggcgagcac ctggtggtgg aagtcccgcc aggcgagctg tcggacgaag gcctccgcgc
    19801 cctcaccgcc gcgctccagc gcgcgcaccg ccagctcggt ggccgacagg cacccgaagt
    19861 gcaggtaggg cgagagccgg gaggtgccgt cgtccgcgag cgcgtcgtgc acgtccgcgt
    19921 aggcgtcgac gtcccacttc cgccaacgtg cccggccggc cgtctccccg ccgggcggca
    19981 gcgcgggcga caccgcacgg gcggtgggca ggtcctcgcc gcgcacggcc ggcggggtgt
    20041 ccagcgaccg gggggcgggc atcacggccc ggcggggcac acgctgccag gcccggtggt
    20101 acggggtgaa gacggcgtag tggtccttcc cggccggggt cacccggcct gccgggacca
    20161 cggtcagcac ggcgtcgtgg acgtgcagcc ggtcgccgag ccgcgcccgc aggccggcct
    20221 cgcgccgctg ggcgaacgcg ctgaccccgg cgccgacgtg cacgctcacc gcgccggtct
    20281 cctcggccag tcgggcagtc tgctcggcgg cgtcgccgtg ccgtacgacc agccgggagc
    20341 cgatccggcg cagcgaggca tccaggtcgg caaggcagtc ggcaaggaag gcctgacggt
    20401 tgggggtgct gaagcccgcg gcctcgacgg cggggtcgag cacgaacacc ggtacgacct
    20461 ggtcggcggc ggcacgggcg gcgtgcagga cggggttgtc gtacaggcgg aggtcctggg
    20521 tgaacagggc gacggagacg gtcatcggcg gtgcctcggg ctggtcgagt gggctgatcg
    20581 gtcgagtggg ctgatccgtc gagtgggctg gtcggtcggg tgggcgtggc ttcggcgcct
    20641 cggtggctac cttgggtatc cgccggtgcg ggccgcgtgc cggcatggtg gcagcggtcc
    20701 accgctgcgg cgagccagta gacatgtcat caggagtggg ccgggcaggt acacccgaca
    20761 gctcggcgtg tcggcggcgg gtcgcagtag gcggcacggc aggcggcgcg tctcacgcgc
    20821 gcggtcgcat ggtcactccg ctgtcagcgc ttgggggtgg acgcgagggt gggtgtgggc
    20881 acgcgggcgg gcgtgagcat gggaccccca tgggagcccc ttggcggctc ggggccggct
    20941 gagcggcctg tcatgcggtc tgcaatgcgg tctgcagctt ccgttcggag ccttgcgctc
    21001 tgcggattgg accagagggc agcggatcgc cgtccgtcgg ccgtcggccg tcggccgct
//
