LOCUS       NZ_CP026498            21107 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. CB01881 chromosome.
ACCESSION   NZ_CP026498
VERSION     NZ_CP026498.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB01881
  ORGANISM  Streptomyces sp. CB01881
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     A 3-hydroxy-3-methylglutaryl-CoA synthase gene based probe for the
            discovery of the acyltransferase-less polyketide synthases
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) Xiangya International Academy of
            Translational Medicine, Tongzipo, Changsha, Hunan 410000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002953255.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 02:39:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,978
            CDSs (total)                      :: 7,904
            Genes (coding)                    :: 7,565
            CDSs (with protein)               :: 7,565
            Genes (RNA)                       :: 74
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 124 of 339
            Pseudo Genes (incomplete)         :: 251 of 339
            Pseudo Genes (internal stop)      :: 10 of 339
            Pseudo Genes (multiple problems)  :: 45 of 339
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:44:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8666188
            Orig. end                         :: 8687295
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026498.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21107
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="29"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21107
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21107
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11107](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11107)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(128..146)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 20.91"
                     /tool="antismash"
     misc_feature    143..161
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.4"
                     /tool="antismash"
     misc_feature    complement(148..166)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.37"
                     /tool="antismash"
     misc_feature    complement(159..172)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     gene            202..489
                     /locus_tag="C2142_RS27890"
                     /old_locus_tag="C2142_27900"
     CDS             202..489
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer2_BFD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557078.1"
                     /locus_tag="C2142_RS27890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27900"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_148645492.1"
                     /sec_met_domain="Fer2_BFD (E-value: 9.9e-14, bitscore:
                     50.3, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYVCMCHAVTEAQVRNEIDAGANSPRQIAKGCKAGTDCGSCVRRI
                     QALLGEHGARPCPTARLAAKLGLADPEAAPSEAAPSEAVPLAPVAPLRAA"
     gene            complement(530..1009)
                     /gene="bfr"
                     /locus_tag="C2142_RS27895"
                     /old_locus_tag="C2142_27905"
     CDS             complement(530..1009)
                     /EC_number="1.16.3.1"
                     /GO_function="GO:0004322 - ferroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008199 - ferric iron binding [Evidence
                     IEA]"
                     /GO_process="GO:0006880 - intracellular sequestering of
                     iron ion [Evidence IEA]"
                     /codon_start=1
                     /gene="bfr"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005478270.1"
                     /locus_tag="C2142_RS27895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27905"
                     /product="bacterioferritin"
                     /protein_id="WP_148645493.1"
                     /transl_table=11
                     /translation="MKGDAEVIEFLNEQLTAELTAINQYFLHAKMQENFGWTKLAKYTR
                     HESFDEMKHAEVLTDRILFLDGLPNYQRLFHVRIGQTVKEMFEADRQVEVEAIDRLKRG
                     IVVMRAKNDVTSANIFEAILEDEEHHIDYLDTQLELLEKLGEALYLAQLIEQPES"
     misc_feature    1089..1103
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.63"
                     /tool="antismash"
     misc_feature    1119..1133
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 13.98"
                     /tool="antismash"
     gene            1227..1856
                     /locus_tag="C2142_RS27900"
                     /old_locus_tag="C2142_27910"
     CDS             1227..1856
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135294.1"
                     /locus_tag="C2142_RS27900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27910"
                     /product="sulfite oxidase-like oxidoreductase"
                     /protein_id="WP_148645494.1"
                     /transl_table=11
                     /translation="MGQPEQEPIPPSDPRLPPGQRPQRGWPALHYGPVPRFKPLAWDFQ
                     VFGATASAEKHSWDFAGFNALPRTTVRADLHCVTKFSMLGNDWTGVSAAAVLAQVPPAP
                     DVTHVMVWAEYGYSANLRLADFADPRTVFATHRNGEPLTAEHGFPVRLVVPQLYAWKGP
                     KWVRAVEYMRADRRGFWEERGYHNLADPWREQRYSYQEEPGDGPLR"
     gene            complement(1860..3206)
                     /locus_tag="C2142_RS27905"
                     /old_locus_tag="C2142_27915"
     CDS             complement(1860..3206)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126250.1"
                     /locus_tag="C2142_RS27905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27915"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_346766398.1"
                     /transl_table=11
                     /translation="MRERVRGAVITPADEGYDEARRVYNGMVDRRPTVIVRVANAGDVM
                     ATVDFARDNTLDLAVRGGAHSAPGFGTCDDGVVIDFSARRGVRIDPERRTAQCEGGVTW
                     GDLNTAGYAFGLGVTGGIISTTGIAGLTLNGGFGHLARGLGLSCDNLISADVVTADGRF
                     RTVSAEQEPDLFWALRGGGGNFGAVTSFEYRLSPVADVVAGPFVYELEHAADVLRFYRE
                     YIQDAPEQLGLFPGFHIAPPLPFVPEDRVGDPFILLVPCWAGPPAEAEKVLAALRDAAP
                     VVAEGVGPAPYPAFAAAFDPLLPPGLQQYWKGVFATELTDGAIAAHVEYGPRVPTVNSA
                     VHLYPINGACHRVPADATAFSHRDATFATVIAGVWPDPADNERNTTWVRDYYAALAPHS
                     DEAGYIGFMDHDDQHRIEANYRGNYDRLVELKQRYDPGNLFHLNQNIRG"
     gene            complement(3398..5218)
                     /gene="pknB"
                     /locus_tag="C2142_RS27910"
                     /old_locus_tag="C2142_27920"
     CDS             complement(3398..5218)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF033483.0"
                     /locus_tag="C2142_RS27910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27920"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_148645496.1"
                     /sec_met_domain="Pkinase (E-value: 3.4e-49, bitscore:
                     166.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKADMALHDPLIGTLLDGRYRVGQRIAAGGMSTVYRGTDTRLDR
                     VVALKVMHPSLAGDEGFTGRFIREAKAVARLAHPNVVNVFDQGADGKTVFLAMEYVPGR
                     TLRDLLRDRGALSIRAALDVLEPVLAALGAAHRAGLVHRDVKPENVLITDGGLVKVADF
                     GLVRVLNAADGAATSTTATSGTVLGTVSYLAPEQIRPGDETDQRVDVYAAGILLYEMLT
                     GHRPHTGENPVQVMYRHLHEDVPAPSLTVPSVVPGLDAIVAGACARDPQARPYDAVELL
                     AALQRVRRTLTPAQLDAEPPTSTLDTPQYPANEPTSVLRPAVTARAVSAAAPDPDAAPP
                     VERTSVLDVPPDVMEQLLAEPRPYDEPPPARTRRPGPWSRLPRKPLVWACVLAALVLLV
                     GGTTYALSGALYTTVPGVLGKDRAEAQRILDGAGMHGRFSEVYSESVPAGQVISTDPGV
                     GARARKSDAVAVTVSRGPKRIAVPELAGKPADQAVAALAAAQLAGGNVTQTYSDTVPEG
                     AVISTSPAAGQQLPENSPVSLVVSRGMVAVPDVTGMSKDDAAKALQAAGFAMQSSGVNL
                     FGTGRVSSQSPAAGERRPQHTVVTVNFPFL"
     gene            complement(5311..6108)
                     /locus_tag="C2142_RS27915"
                     /old_locus_tag="C2142_27925"
     CDS             complement(5311..6108)
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135291.1"
                     /locus_tag="C2142_RS27915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27925"
                     /product="thiazole synthase"
                     /protein_id="WP_148645497.1"
                     /transl_table=11
                     /translation="MADDLLTIAGTTFGSRLIMGTGGAPSLEVLEQALRVSGTELTTVA
                     MRRVNATTQGSVLDVLTRNGIRILPNTAGCFTAGEAVLTARLAREALGTDWVKLEVIAD
                     ERTLLPDPIELLDAAETLVDDGFTVLPYTNDDPVLARKLEDAGCAAIMPLGSPIGSGLG
                     IRNPHNFQLIVESANVPVILDAGAGTASDVALAMELGCAAVMLASAVTRAQDPVLMAEA
                     MRYAAEAGRLAHRAGRIPRRFHAEASSAMAGRADLDTREHPAF"
     gene            complement(6111..6320)
                     /gene="thiS"
                     /locus_tag="C2142_RS27920"
                     /old_locus_tag="C2142_27930"
     CDS             complement(6111..6320)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135290.1"
                     /locus_tag="C2142_RS27920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27930"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_174315756.1"
                     /transl_table=11
                     /translation="MSDIPLTVNGEPRQVPAATTLAEVVATLSRSSSGVAAALNETVVP
                     RGSWPLTQLSAGDRIEILTAVQGG"
     gene            complement(6317..7501)
                     /gene="thiO"
                     /locus_tag="C2142_RS27925"
                     /old_locus_tag="C2142_27935"
     CDS             complement(6317..7501)
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180425.1"
                     /locus_tag="C2142_RS27925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27935"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_241002817.1"
                     /sec_met_domain="DAO (E-value: 9.8e-70, bitscore: 234.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRSAPDAHAGVLVIGGGIIGLAVAWRAAQHGLKDIVVADPRPGG
                     GAAQVAAGMLAPVTELQYGEEPLLRLGMASNERYAAFAAELTEASGGQDTGYRQCGTIA
                     IALDSDDREELRELHAFHQRLGLDSRWLTGREARRLEPMLAPGVRGGLHVTGDHQVDGR
                     RLAKALVLACERAGVRLHRAEATALVVDGGRATGARLATGGTVTADQVVLAAGPQSHLL
                     PGLPEGVLPAIRPVKGQILRLHVPPAYRPFLSRNVRAVVRGQHLYLVPRENGELVIGAT
                     TEEQGYDTTVTAGGVYELLRDAHELVPGITELPLVETAAGLRPGSPDNAPLLGPTALPG
                     LVAATGHYRNGVLLTPVTADLVAGYLATGTTPDLAAPFSPTRFAPTGSTTKVPA"
     regulatory      complement(7496..7608)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    7526..7539
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            7702..8898
                     /locus_tag="C2142_RS27930"
                     /old_locus_tag="C2142_27940"
     CDS             7702..8898
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135288.1"
                     /locus_tag="C2142_RS27930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27940"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_148645498.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-57, bitscore:
                     194.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELSGTDQVVVVGAGLAGAQCASGLRRGGWPGRIVLVGDEPHAP
                     YDRPPLSKEVLLGKADATTLDIDFPHLGIELLTGRRATGLTPGVLHTDGGDLPYGALVI
                     ATGAVPRVLPGAERAHLLHTLDDALALRALLRPGLRLVLVGAGWIGAEVATAARAAGCE
                     VTVVEAGPAPVPGALPTEVGRAMAAWYAEAGVELRCGAAVEAVEPGAVLLADGSHLPAD
                     EVVVGIGARPATDWLAGSGVGLDAAGAVLVDEGLRTGLPGVYAAGDCASYPSARTGARL
                     TVQHWDHALQSGEAAAAAVLGADVPYDPVPYFWSEQFGRMVQYAGRHGDGDELLWRGSP
                     ADASWAVLWLRGGVLRALLAVDRPRDLTQGRRLVERGAVLDPARAADPSVPLKSAVAG"
     gene            8950..9315
                     /locus_tag="C2142_RS27935"
                     /old_locus_tag="C2142_27945"
     CDS             8950..9315
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129955.1"
                     /locus_tag="C2142_RS27935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27945"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_148645499.1"
                     /transl_table=11
                     /translation="MSEIESKIEALVTEWMYLPDISEQWGVRVTEVRDLVKNGGLIAVR
                     RGPNRSLQVPAAFIDGQGLVKHLSGTLTVLRDCGYNDEEILEWLFTEDPSLPGSPIQAL
                     QENRGTEVKRRAQAMLI"
     gene            9315..9965
                     /gene="thiE"
                     /locus_tag="C2142_RS27940"
                     /old_locus_tag="C2142_27950"
     CDS             9315..9965
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004932250.1"
                     /locus_tag="C2142_RS27940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27950"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_148645500.1"
                     /transl_table=11
                     /translation="MAADTLRRRLADARLYLCTDARREQGDLAEFLDAALSGGVDIVQL
                     RDKGLEARQELEALEVFADACRRHGKLLSVNDRADVAHAARPEVLHLGQDDLPVPAARA
                     ILGEDVLIGRSCHAESEVDAAVAEPGVDYFCTGPVWPTPTKPGRHAPGLGLVSYAAKQV
                     TDRPWFAIGGIDLGNLDEVLAAGASRVVVVRAITAADDPQAAAAALSRRLRQA"
     gene            complement(10001..11107)
                     /locus_tag="C2142_RS27945"
                     /old_locus_tag="C2142_27955"
     CDS             complement(10001..11107)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020552950.1"
                     /locus_tag="C2142_RS27945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27955"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_241002818.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.9e-44, bitscore:
                     149.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSSNRPANPIDVEDVRGRVNAALAGFMDGQAALLGKISPQLAP
                     AAEALRDFLLDGGKRLRPAFCYWGWRGAGGAAAGEGIANAAAALELLQASALVHDDLMD
                     RSDTRRGLPSVHRRFEALHRDSGWRGDREQYGTSAAVLLGDLLLIWCDELFLRSGLDPA
                     AVLAAKPVFDLMRTEVMVGQYLDVLEPVAGDSTDEGALDRAQTVLHYKSAKYTIERPLQ
                     IGALLAGARPELVEAYGAFGLPLGEAFQLRDDLLGVFGDPAVTGKPAGDDLREGKRTLL
                     VAHAMRGLPAADARHLDERLGAPDLAPEEVARLRGLVERSGAPELVELRIEELMRQSLA
                     ALEAAPLADARAREVLLALAEAATVRKY"
     misc_feature    11233..11246
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.18"
                     /tool="antismash"
     misc_feature    complement(11233..11247)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.54"
                     /tool="antismash"
     misc_feature    11234..11247
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.21"
                     /tool="antismash"
     misc_feature    complement(11235..11248)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.82"
                     /tool="antismash"
     misc_feature    complement(11240..11249)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     gene            11295..12209
                     /gene="metF"
                     /locus_tag="C2142_RS27950"
                     /old_locus_tag="C2142_27960"
     CDS             11295..12209
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135283.1"
                     /locus_tag="C2142_RS27950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27960"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_148645501.1"
                     /transl_table=11
                     /translation="MALGIASTRTDRALTVRELLAAGKRSFSFEFMPPRTEVGEQRLWD
                     AIRRLEPLDPNFVCMTYGAGGSSRERTVNMVGRIATETTLTPVAHLTAVDHSVAELRNI
                     IGQYADQGVRNVLAVRGDPPGDPMGEWVKHPQGVTYAYELVELIKGIGDFCVGVAASPN
                     MHPRSTDWDEDIRHFVAKIRSGADYAITQMFFEVDDYLRLRDRVAAAGCETPIIPEIMP
                     VTNAKQLDRFPQLSGSAFPAELEARLRAAIDDPAALREVGMEHATAMSERLLAEGAPGL
                     HFITLNHSTATLEIYQNLGLHQR"
     gene            12362..13267
                     /locus_tag="C2142_RS27955"
                     /old_locus_tag="C2142_27965"
     CDS             12362..13267
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008738740.1"
                     /locus_tag="C2142_RS27955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27965"
                     /product="hypothetical protein"
                     /protein_id="WP_148645502.1"
                     /transl_table=11
                     /translation="MGIGYLLLYAALAVVALWLVAELLLQNRAPVHWRALALAGFLGVP
                     AGMAAGSVVVIGAGAALFAVGQTLVTLSVKRGYAAGWSLRTADGGLPGPLAKVPLLGAL
                     TGGAAVATAVAADRIGTVSAVEESPEPGPADEDVPAVEQTAAFEMQEIAADDGVYAPAY
                     YEQQQPQQVQQAQPDPYAEAYQAGYDPAQQQAAWDQNAQQQQQQWQTQQQPAFAYDQGY
                     GGYQQQAVQPDQYAAYQQQPDAYGTYQQQSGQQQYGYDQQAQQQQQQWQPQQDQQQGIP
                     QQPQYDQYGYQQQNTWQQQG"
     gene            complement(13311..14816)
                     /locus_tag="C2142_RS27960"
                     /old_locus_tag="C2142_27970"
     CDS             complement(13311..14816)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006383019.1"
                     /locus_tag="C2142_RS27960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27970"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_148645503.1"
                     /sec_met_domain="DAO (E-value: 3.6e-07, bitscore: 28.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARIVIIGAGMSGLAAASRLATLGHRVTVCEAGATYGGMVGRYER
                     DGFAFDTGPGLLTLPAVYRDLALKTGKEPLEQLVKLAPVEPESRHLFADGTDLVLPNAS
                     RGGVVQALDAAFGAGSGARWAEVMNHGRTVWEATRRPLLEEPLPADPTPLHTDPYPAPP
                     RKGLLSRLFRPAPWTLTGVAAHGLDGHPGLTALLNEYALRYGLHPDTAPASATVLPYME
                     QSFGVWYVKGGVRALADAVYRRCEQRKVDFRFGTEVTAVAVEDGRAVGVDTADGRIDAD
                     LVVSSMDAWELFRRRVAEWPGDGDPNEWARQNEEPKGRFRVLLALRGARPEGTVHRTVV
                     HAADPAAEWNALTLSAGLCERPTVEVLRPDDPSLRPDDGHESVVLTVTVPAQGDVDWTE
                     PGLAERYADRLLDHVDAAGLGLRERVLWRVVRTPEDTRRETGAFMGAVTLPALAGGDGR
                     WLQYANESPVPGLYLVGGAAHPGGGLARVGMSACIAANLIGPA"
     gene            complement(14826..15458)
                     /locus_tag="C2142_RS27965"
                     /old_locus_tag="C2142_27975"
     CDS             complement(14826..15458)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135280.1"
                     /locus_tag="C2142_RS27965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27975"
                     /product="DUF4126 domain-containing protein"
                     /protein_id="WP_148645504.1"
                     /transl_table=11
                     /translation="MTILPLIFTSGLASGINAYAVVLLLGLLGRFAGAGSVPPALERTD
                     VLVAAAVLFLLEAVADKIPYVDSVWDAVHTVIRPIAGATVGALIASAEPGSLPEVAAGA
                     VGGTTALVSHLVKASLRMAVNTSPEPASNIAVSLAEDLSVAGLVTLAIFHPWLAASIAA
                     ALLIAGLLLVRFAVNRIRRFRARRRERRAARLAGRAQPAAGAYSAQP"
     misc_feature    complement(15409..15422)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            16020..16625
                     /locus_tag="C2142_RS27970"
                     /old_locus_tag="C2142_27980"
     CDS             16020..16625
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019327986.1"
                     /locus_tag="C2142_RS27970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27980"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_162002557.1"
                     /transl_table=11
                     /translation="MTVSRPEPVTARLHSAAHRPTPHRSEGHQPGTHAPAAGDVHPVLR
                     RVAAPPAALDLLADAHRTLTRSRSLEDPLERYAAAHLAALRTVAAVLAVRGRPEKSPRR
                     RRAIRSAWEVLPEMAPELAEWAVYFAAGARRRAAAEAGIRGAASARDADDLIRNSALFL
                     RLVERLLGLHPVRPAPRLPPDDGDAGRTPGPGGDRGRA"
     gene            16740..17492
                     /locus_tag="C2142_RS27975"
                     /old_locus_tag="C2142_27985"
     CDS             16740..17492
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090237.1"
                     /locus_tag="C2142_RS27975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27985"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_148645505.1"
                     /transl_table=11
                     /translation="MYPTRPRSALRTAVVWEVVRAALEKRAAELDRPVLDVVDTGGGTG
                     NFAVPVARLGHRVTVVDPSPDALFALERRAAEAGVTDLVRAVQGDTQTLPELVAPGTVD
                     AVLCHGVLEVVDDPAEALGSLADTLRRGGFVSLLAANRNGAVLARALGGHFNDARTVLE
                     AADGRWGDTDPMPRRFTGEELDRLAVDAGLRVDSVHGVRVFADLVPGVLVDAEPGALDA
                     LLKLEEAAAEQPAFHAVATQLHLLATLA"
     misc_feature    complement(17684..17697)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     misc_feature    complement(17755..17770)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.59"
                     /tool="antismash"
     misc_feature    complement(17768..17781)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.25"
                     /tool="antismash"
     gene            17858..18247
                     /locus_tag="C2142_RS27980"
                     /old_locus_tag="C2142_27990"
     CDS             17858..18247
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006383037.1"
                     /locus_tag="C2142_RS27980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27990"
                     /product="DUF3040 domain-containing protein"
                     /protein_id="WP_148645506.1"
                     /transl_table=11
                     /translation="MPLSEHEQRLLDQMERALYAEDPKFASALEGTGLRTYTRRRVYLA
                     VGGFVVGIGLLMGGMVVPDQIWVSVVGFLVMLGCAVFAVTGWRRGPAGQASGPRPAAAP
                     HRKAGMMDRVEQRWQRRRDEQTGGF"
     gene            complement(18380..20830)
                     /locus_tag="C2142_RS27985"
                     /old_locus_tag="C2142_27995"
     CDS             complement(18380..20830)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023418.4"
                     /locus_tag="C2142_RS27985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_27995"
                     /product="DUF3488 and transglutaminase-like
                     domain-containing protein"
                     /protein_id="WP_148645507.1"
                     /transl_table=11
                     /translation="MTTRAKLTVYSALATALASLCLAPLLTGKSWIVYALLVVLAVAAS
                     GAGLRRTPFYRWTVPLGQLLVLFVLLLVGFASATNRFGGMVPGPESVRTLGQVLGHGLD
                     DIREYAIPAPPNPGLRLILVSSVGLIAIAVDTVAVTYRRSALAGLPLLALYSVGNGLAG
                     DRGSWVWFGLASTGYLVLLFAEGQDRVSRWGRVFRGTSRGGEGGTLSLSGQRVGVLALA
                     LALLVPAFLPRWDGGLIHTGPKGTAAGTGAGGVTSLDPLVTLESALTKPSDIELLTYRM
                     DSSLADTAYLRTGSLDVFDGAAWKLGSPGTTDFKGTFAPPEGLRDLGVPTVPGDFQVTN
                     NLDSAWLPMPYPAKSATVPNPGSWRVDTLTGTVQPAGGKEKAIKGLHYQVTAYDVRPTA
                     EDLRQALPARPQIAGHYTDLPGDLPSVVRQQAQAVTSRAPTAYDKALALQDWFTGPDFT
                     YTTQIKSGTGNDAIVEFLRNRKGFCVHFASTMAAMARTLGIPSRVAVGFTPGNAKGGDR
                     YSVNGLMYHAWPELYFEGFGWTRFEPTKGVGVAPRYTEPVAAPTSAPTTAPTAAAQSTA
                     PVAVPSRSSDCDPKLRRTGDCGDQKKGSAGAREDSWLLSWQVLSTLAAVLVVIALLLTP
                     MLWRTLLRRRRLGAGGRRRPGGDGPAELTDEQVLAAWDELIDSAWDLGIPPDESRTPRA
                     AARRISETAELDEASAAAAGRVALATERVLYARSARVSAPLAADVRTARDGLRAGTDRA
                     GRTRAVLLPPSSAQLWWKLSDAVLGVRLAVRRRAARVAGAVTGPVRRLWDRLRRRGGTD
                     GTAS"
ORIGIN
        1 ggccgccgcg gccccggccc ggcccggtcg ggcctgatcg gcgctggtcg gccctgatgt
       61 gacgaaggcc cctccggatt cgggattccc gagcccggag gggctttttc acgccaggat
      121 tgccgggtaa ggtgaggctt agtgagctaa ggcaagcctt agtcaagatc cactccgctg
      181 caccccccgg gagagaccgc gatgtacgtg tgcatgtgtc atgcggtcac cgaggcccag
      241 gtgaggaacg agatcgacgc gggtgccaac tccccgcgcc agatcgccaa ggggtgcaag
      301 gccggaaccg actgcggctc ctgcgtccgg cgcatccagg ccctgctggg cgagcacggc
      361 gcgcggccct gcccgaccgc ccggctggcc gcgaagctgg ggctcgccga cccggaggcc
      421 gcgccgtcgg aggccgcacc gtcggaagcg gtgccgctcg ccccggtcgc cccgctgcgc
      481 gcggcctgag cgcccgggcg cccggcgggg tccggcgcgc cggacgggct caggactccg
      541 gctgctcgat cagctgggcg aggtagagcg cctccccgag cttctccagc agctccagct
      601 gggtgtcgag gtagtcgatg tggtgctcct cgtcctccag gatggcctcg aagatgttgg
      661 ccgaggtgac gtcgttcttg gcgcgcatca ccacgatccc gcgcttgagc cggtcgatcg
      721 cctcgacctc gacctggcgg tcggcctcga acatctcctt gacggtctgg ccgatccgga
      781 cgtggaagag ccgctggtag ttgggcagcc cgtccaggaa gaggatccgg tcggtgagca
      841 cctcggcgtg cttcatctcg tcgaaggact cgtgccgggt gtacttggcg agcttggtcc
      901 agccgaagtt ctcctgcatc ttggcgtgca ggaagtactg gttgatggcg gtcagctcgg
      961 cggtgagctg ctcgttgagg aattcgatga cctctgcgtc gcccttcatg gcgctgcctt
     1021 cctgctgtgc gtcggggaac ctcggccgtg cccgcggctg gaacgcatcc tggcaccgcg
     1081 atgggaagaa attccagtaa gttcacactc actaggacat gtgtcggaat atctgatttg
     1141 gtcggttatt ggcccgtacg ggcgggcgta cggcaccgga aaggggcgcg caccgggcgt
     1201 tgtccgccgt ctgtcaccat ggagccatgg gtcagcccga acaagaaccg atcccgccgt
     1261 ctgacccgag gctccctccg ggacagcgcc cgcaacgcgg ctggcccgcc ctgcactacg
     1321 gaccggtgcc ccgcttcaag ccgctggcct gggacttcca ggtgttcggc gcgaccgcct
     1381 cggcggagaa gcacagctgg gacttcgccg gcttcaacgc cctgccgcgc accaccgtcc
     1441 gggccgacct gcactgcgtc accaagttct cgatgctcgg caacgactgg acgggcgtgt
     1501 cggccgcggc cgtactggcg caggtgcccc cggcgcccga cgtcacccac gtgatggtct
     1561 gggccgagta cggctacagc gccaacctgc ggctggccga cttcgccgac ccgcggaccg
     1621 tcttcgccac ccaccgcaac ggcgagccgc tcactgccga gcacggcttc cccgtccggc
     1681 tggtcgtccc gcagctctac gcctggaagg ggcccaagtg ggtccgggcg gtggagtaca
     1741 tgcgggccga ccggcgcggc ttctgggagg agcgcgggta tcacaacctc gccgacccct
     1801 ggcgggaaca gcgctactcc taccaggagg agccgggcga cgggccgctg cggtagccgt
     1861 cagccccgga tgttctggtt gaggtggaac aggttgccgg ggtcgtaccg ctgcttcagc
     1921 tccaccaggc ggtcgtagtt gccccggtag ttggcctcga tccggtgctg gtcgtcgtgg
     1981 tccatgaagc cgatgtagcc ggcctcgtcg gagtgcgggg cgagcgcggc gtagtagtcg
     2041 cgcacccagg tcgtgttccg ctcgttgtcg gcggggtccg gccagacgcc ggcgatcacg
     2101 gtggcgaagg tcgcgtcccg gtgggagaag gccgtcgcgt cggcgggcac gcggtggcag
     2161 gcgccgttga tcgggtagag gtgtaccgcc gagttgaccg tcggcacccg cggcccgtac
     2221 tccacgtgcg cggcgatcgc cccgtcggtg agctcggtcg cgaagacgcc cttccagtac
     2281 tgctggagcc cgggcggcag cagcgggtcg aaggcggcgg cgaacgccgg gtacggtgcc
     2341 gggccgacac cctcggccac caccggcgcc gcgtcccgca gcgcggcgag caccttctcc
     2401 gcctcggccg gcggcccggc ccagcagggg accagcagga tgaaggggtc gccgacccgg
     2461 tcctccggta cgaacggcag cggtggggcg atgtggaagc cggggaagag gcccagctgc
     2521 tcgggggcgt cctggatgta ctcgcggtag aagcgcagca cgtcggccgc gtgctccagc
     2581 tcgtagacga acggcccggc gaccacgtcg gcgaccggac tcagccggta ctcgaaggac
     2641 gtcaccgcgc cgaagttgcc gccgcctccg cgcagcgccc agaagaggtc cggctcctgc
     2701 tccgcgctca ccgtgcggaa ccggccgtcg gcggtgacca cgtcggccga gatcaggttg
     2761 tcgcagctca ggcccagtcc gcgggccagg tggccgaagc cgccgttgag ggtcagcccg
     2821 gcgatgccgg tggtggagat gatccccccg gtgacgccga gaccgaaggc gtaccccgcg
     2881 gtgttgaggt cgccccaggt gacgccgccc tcgcactgcg cggtccggcg ttccgggtcg
     2941 atccgcacgc cccgccgcgc ggagaagtcg atcaccacgc cgtcgtcgca ggtgccgaag
     3001 ccgggcgcgc tgtgggcgcc gccgcggacc gccaggtcca gcgtgttgtc ccgggcgaag
     3061 tcgacggtgg ccatcacgtc ccccgcgttg gccacccgga cgatcacggt cggccggcgg
     3121 tccaccatgc cgttgtagac ccggcgcgcc tcgtcgtagc cctcgtccgc aggggtgatc
     3181 accgcgcccc gcacacgctc cctcaagccg tcgacggtgg gtccgcccat gacgaccaca
     3241 tcctcgggta ccggccgccg cgcagccccg tccggaggtc ccggtgccgc agccctcccg
     3301 gctgtggcgg gcggggccgg gcaggcctgg ttccacgcta cgccgggtgc gccccggggg
     3361 cctgtccgtc ggacacgccc ccggggccgg aaagtcctca gaggaagggg aagttgaccg
     3421 tcaccacggt gtgctgcggc cggcgttcgc cggcggcggg ggactggctg gagacccttc
     3481 cggtgccgaa caggttgacg ccgctgctct gcatcgcgaa cccggcggcc tggagcgcct
     3541 tggcggcgtc gtccttggac atcccggtga cgtccgggac ggccaccatg cccctgctga
     3601 ccaccagcga gaccggcgag ttctccggca gctgctgccc ggccgccggg gaggtgctga
     3661 tcaccgcacc ctccggcacg gtgtcgctgt acgtctgggt gacgttgccg ccggccaact
     3721 gggcggcggc cagcgcggcg acggcctggt cggcgggctt gccggccagc tccggcacgg
     3781 cgatccgctt agggccgcgg gagacggtga cggcgaccgc gtcgctcttg cgggcccggg
     3841 caccgacccc cgggtcggtc gagatcacct gaccggccgg gacgctctcg ctgtacacct
     3901 cgctgaaccg cccgtgcatg cccgcgccgt ccaggatccg ctgcgcctcg gcgcggtcct
     3961 tgccgagcac gcccggcacc gtcgtgtaca gggcgccgga gagcgcgtac gtggtgccgc
     4021 cgaccagcag caccagggcg gccagcacgc aggcccagac cagcggcttg cgggggaggc
     4081 ggctccacgg gccggggcgg cgggtgcgcg ccggcggcgg ctcgtcgtag gggcgcggct
     4141 cggcgagcag ctgctccatc acgtccggcg ggacgtccag cacgctggtc cgctcgaccg
     4201 gcggcgcggc gtccgggtcg ggggccgccg cggagacggc ccgggcggtg acggcgggcc
     4261 ggagcaccga ggtcggctcg ttggccgggt actgcggggt gtccagggtg gaggtgggcg
     4321 gttcggcgtc cagctgggcc ggggtgagcg tgcggcgcac ccgctggagg gcggccagca
     4381 gctcgaccgc gtcgtacggg cgggcctgcg ggtcgcgcgc gcaggcgccg gccactatgg
     4441 cgtccagccc ggggacgacg ctcggcacgg tgagcgaggg cgcggggacg tcctcgtgca
     4501 ggtggcggta catcacctgg acggggttct cgccggtgtg cgggcggtgg ccggtgagca
     4561 tctcgtacag caggatgccg gcggcgtaga cgtccacccg ctggtcggtc tcgtcgccgg
     4621 ggcggatctg ctcgggggcg aggtaggaga cggtgccgag gacggtgccg gaggtcgccg
     4681 tggtggaggt ggccgcgccg tcggcggcgt tcaggacccg gaccagtccg aagtcggcga
     4741 ccttgaccag gccgccgtcg gtgatcagca cgttctcggg cttcacgtcg cggtggacga
     4801 gcccggcccg gtgggcggcg ccgagcgcgg cgagcaccgg ctccaggacg tccagggcgg
     4861 cgcggatgga gagcgcgccg cggtcgcgca gcaggtcgcg cagggtccgg ccggggacgt
     4921 actccatggc gaggaagacg gttttgccgt ccgcaccctg gtcgaagacg ttgaccacgt
     4981 tggggtgcgc gagccgggcg acggccttgg cctcgcggat gaaccggccg gtgaagccct
     5041 cgtcgccggc cagcgagggg tgcatcacct tgagcgccac gacccggtcg agccgggtgt
     5101 cggtgccgcg gtagacggtg gacatcccgc cggcggcgat gcgctgcccg acccggtacc
     5161 ggccgtcgag cagggtaccg atcagagggt cgtgcaatgc catgtccgcc ttgtccaccc
     5221 ggcgagtcta gtggcgcata cgggtgaggg ccccgggaga caccgctccc ggggccctct
     5281 gtgcccggct tgtgacacgc cccccggggc tcagaacgcc gggtgttcgc gggtgtcgag
     5341 gtcggcccgg ccggccatcg cggaggaggc ctcggcgtgg aagcggcgcg ggatgcggcc
     5401 ggcccggtgg gcgagccggc cggcctcggc ggcgtaccgc atcgcctcgg ccatcagcac
     5461 cgggtcctgg gcgcgggtca ccgccgaggc gagcatgacg gcggcgcagc ccagctccat
     5521 cgccagtgcg acgtccgagg cggtgccggc gcccgcgtcc aggatcaccg ggacgttcgc
     5581 gctctccacg atcagctgga agttgtgcgg gttgcggatg cccaggccgg agccgatcgg
     5641 cgagccgagc ggcatgatcg ccgcacagcc ggcgtcctcc agcttccggg ccagtaccgg
     5701 gtcgtcgttg gtgtagggca ggacggtgaa gccgtcgtcg accagcgtct cggcggcgtc
     5761 cagcagctcg atcgggtcgg gcagcagcgt ccgctcgtcg gcgatgacct ccagcttcac
     5821 ccagtcggtg ccgagcgcct cgcgggccag ccgggccgtc agcacggcct ccccggcggt
     5881 gaagcagccg gccgtgttgg gcaggatccg gatgccgttg cgggtgagca cgtccaggac
     5941 ggagccctgg gtggtggcgt tgacccggcg catcgccacg gtggtcagct cggtgccgga
     6001 gacccgcagc gcctgctcca ggacctccag gctgggggcg ccgccggtgc ccatgatcag
     6061 gcgcgagccg aaggtggtgc cggcgatggt gagcaggtcg tcagccatgg tcagcctccc
     6121 tgcacggcgg tgaggatctc gatccggtcg cccgccgaga gctgcgtgag cggccacgaa
     6181 ccacgcggca ccacggtctc gttgagcgcg gcggcgacgc ccgaggagga ccggctgagg
     6241 gtggccacca cctcggcgag ggtggtcgcg gcgggcacct ggcggggctc gccgttgacg
     6301 gtgaggggga tgtcgctcat gcggggacct tcgtcgtgga gccggtgggg gcgaagcggg
     6361 tgggggagaa cggcgcggcg aggtccggcg tcgtgccggt ggccaggtag ccggcgacca
     6421 ggtcggcggt caccggggtg agcagcacgc cgttgcggta gtggccggtg gcggcgacca
     6481 ggccgggcag ggcggtcggc ccgagcagcg gcgcgttgtc cggcgagccc gggcgcagcc
     6541 cggcggcggt ctccaccagc ggcagttcgg tgatgccggg gaccagctcg tgggcgtcgc
     6601 gcagcagctc gtacacgccg ccggcggtga cggtggtgtc gtacccctgc tcctcggtgg
     6661 tcgcgccgat caccagctcg ccgttctcgc ggggcaccag gtagaggtgc tggccgcgga
     6721 ccaccgcgcg gacgttgcgg gacaggaagg gccggtacgc gggcgggacg tgcagccgca
     6781 ggatctggcc cttgaccggg cggatggccg gcagcactcc ctcgggcagc ccgggcagca
     6841 ggtggctctg cggcccggcg gccagcacga cctgatcggc ggtcacggtc ccgccggtgg
     6901 cgagccgggc gccggtggcg cggccgccgt cgaccaccag agcggtggcc tcggcgcggt
     6961 gcagccggac gccggcccgc tcgcaggcga ggacgagggc cttggcgagc cgtcggccgt
     7021 cgacctggtg gtcgccggtg acgtgcaggc cgccgcggac gcccggggcg agcatcggtt
     7081 cgagcctgcg ggcctcgcgg ccggtgagcc accgcgagtc caggccgagc cgctggtgga
     7141 aggcgtgcag ctcgcggagc tcctcgcggt cgtccgagtc gagggcgatg gcgatcgtgc
     7201 cgcactggcg gtagccggtg tcctggccgc cgctggcctc ggtgagttcg gcggcgaagg
     7261 ccgcgtaccg ctcgttggag gccatgccga ggcgcagcag cggctcctcg ccgtactgga
     7321 gttcggtgac gggtgcgagc atgccggccg cgacctgggc ggcgccgccg ccgggccggg
     7381 ggtccgccac cacgatgtcc ttcagcccgt gctgggcggc gcgccaggcg acggcgaggc
     7441 cgatgatgcc cccgccgatc accagcacgc cggcgtgggc gtccggtgcc gagcgtgtca
     7501 aagtcgctgc tctcccttcg ccggtatgac ccggatcagg ttcggacggt cgcaggccgt
     7561 gtcagcccgc ctctcagccc ggtccgccgg gctcccgtga tggtgccccc accttaacgc
     7621 cgggggtcgg cgccgccgaa ggcgtgtacg aggggtggga cggcgcccgg cgcccccggc
     7681 gggcgccagt acagtgacgg cgtggcagag ctgagcggga cggatcaggt ggtcgtggtc
     7741 ggggccgggc tggccggggc gcagtgcgcc tcggggctgc ggcggggcgg ctggccgggg
     7801 cgcattgtgc tggtgggcga cgagccgcac gcgccgtacg accggccgcc gctctccaag
     7861 gaggtgctgc tcggcaaggc cgacgccacc accctggaca tcgacttccc gcacctgggc
     7921 atcgagctgc tcaccggccg ccgcgccacc ggcctcaccc ccggcgtgct gcacaccgac
     7981 ggcggcgacc tgccgtacgg cgccctggtg atcgccaccg gagccgtccc gcgcgtcctg
     8041 cccggcgccg agcgcgcgca cctgctgcac accctggacg acgccctggc cctgcgcgcc
     8101 ctgctccgcc cgggcctgcg cctggtgctg gtcggcgcgg gctggatcgg cgccgaggtg
     8161 gccaccgccg cccgcgcggc cggctgcgag gtgaccgtgg tcgaggcggg cccggcgccc
     8221 gtccccggcg cgctgcccac cgaggtcggc cgggcgatgg ccgcctggta cgccgaggcc
     8281 ggggtcgagt tgcgctgcgg cgccgccgtc gaggccgtcg agcccggcgc ggtgctgctg
     8341 gcggacggct cgcacctgcc ggcggacgag gtggtggtcg gcatcggcgc ccgcccggcg
     8401 accgactggc tggccggctc cggcgtcggg ctggacgcgg ccggcgccgt cctggtggac
     8461 gaggggctgc gcaccggcct gcccggcgtc tacgcggccg gcgactgcgc gagctacccc
     8521 tccgcccgga cgggcgcccg gctgaccgtc cagcactggg accacgcgct gcagtccggc
     8581 gaggcggcgg ccgccgccgt cctcggcgcg gacgtgccgt acgacccggt gccgtacttc
     8641 tggtcggagc agttcggccg gatggtgcag tacgccgggc gccacggcga cggcgacgag
     8701 ctgctctggc ggggatcgcc ggcggacgcc tcctgggcgg tgctctggct gcgcggcggt
     8761 gtgctgcgcg ccctgctcgc cgtcgaccgc ccgcgcgacc tcacccaggg ccgccggctg
     8821 gtcgagcgcg gcgcggtgct ggatccggcc cgggcggcgg acccgtcggt gcccctgaag
     8881 tcggccgtcg cgggctgacg gaccgtccct ttggtgcgcg gcgggccgca gaggtggcag
     8941 tctggtggcg tgagtgagat cgaaagcaag attgaagccc tggtcaccga gtggatgtac
     9001 ctgcccgaca tctcggagca gtggggggtc cgggtcaccg aggtgcgtga cctggtcaag
     9061 aacggtggcc tgatcgccgt ccggcgcggc ccgaacaggt cgctccaggt cccggccgcg
     9121 ttcatcgacg gtcaggggct ggtcaagcac ctgtccggca ccctgaccgt gctgcgcgac
     9181 tgcgggtaca acgatgaaga gatcctggag tggctcttca ccgaggaccc gtcgctgccg
     9241 ggcagcccga tccaggcgct ccaggagaac cgcggcaccg aggtcaagcg ccgcgcccag
     9301 gcgatgctga tctgatggcc gcggacacgc tgcgccggcg cctcgccgac gcccggctct
     9361 acctgtgcac cgacgcccgg cgggagcagg gcgacctcgc cgagttcctg gacgccgcgc
     9421 tgtcgggcgg ggtggacatc gtccagctcc gtgacaaggg gctggaggcc aggcaggagc
     9481 tggaggcact ggaggtcttc gccgacgcct gccgccggca cgggaagctg ctctcggtca
     9541 acgaccgcgc cgacgtcgcg cacgccgccc gccccgaggt gctccacctc ggccaggacg
     9601 acctgccggt gccggcggcc cgggcgatcc tgggcgagga cgtgctgatc ggccgttcct
     9661 gccacgccga gtccgaggtg gacgcggcgg tcgccgagcc cggcgtggac tacttctgca
     9721 ccgggccggt ctggcccacc ccgaccaagc ccggccggca cgcgcccggc ctcggcctgg
     9781 tctcgtacgc ggcgaagcag gtcaccgacc ggccgtggtt cgccatcggc ggcatcgacc
     9841 tgggcaacct ggacgaggtg ctggcggccg gggcgagccg ggtcgtggtg gtgcgcgcca
     9901 tcacagccgc ggacgacccg caggccgccg ccgcggcgct gtcccggcgg ctgcgccagg
     9961 cctgacgccg cgcggggccg ccgccgttcc cggactcgtc tcagtacttc cggacggtgg
    10021 cggcctcggc cagcgccagc agcacctcgc gggcccgcgc gtcggccagc ggcgcggcct
    10081 ccagcgcggc cagcgactgc cgcatcagct cctcgatgcg gagctccacc agctcgggcg
    10141 cgccgctgcg ctcgaccagc ccgcgcagcc gggccacctc ctcgggcgcg aggtccggcg
    10201 cgccgagccg ctcgtccagg tggcgggcgt cggcggccgg cagcccgcgc atcgcatgcg
    10261 cgaccagcag ggtccgcttg ccctcgcgca ggtcgtcccc ggcgggcttg ccggtgaccg
    10321 ccgggtcgcc gaagacgccg agcaggtcgt cccggagctg gaacgcctcg cccagcggca
    10381 ggccgaacgc cccgtacgcc tcgaccagtt ccggccgcgc gcccgcgagc agcgcgccga
    10441 tctggagcgg ccgctcgatc gtgtacttgg ccgacttgta atgcagcacc gtctgcgccc
    10501 ggtccagtgc gccctcgtcg gtggagtcgc cggcgaccgg ctccagcacg tccaggtact
    10561 ggccgaccat gacctcggtg cgcatcaggt cgaacaccgg cttggcggcc agcaccgccg
    10621 ccgggtccag gcccgagcgc aggaacagct cgtcgcacca gatcagcagc aggtcgccga
    10681 gcagcaccgc ggccgaggtg ccgtactgct cgcggtcgcc gcgccagccg ctgtcgcggt
    10741 gcagggcctc gaagcggcgg tgcaccgagg gcaggccgcg ccgggtgtcg ctgcggtcca
    10801 tcaggtcgtc gtggaccagc gcgctcgcct ggagcagctc cagggcggcc gccgcgttgg
    10861 cgatgccctc gccggccgcc gcgccgccgg cgccgcgcca gccccagtag cagaacgccg
    10921 ggcgcagccg cttgccgccg tccagcagga agtcgcgcag cgcctcggcc gcgggcgcca
    10981 gctgcgggga gatcttcccg agcagggccg cctggccgtc catgaagccg gcgagggccg
    11041 cgttgacgcg cccgcgcacg tcctccacgt caatggggtt ggccggccgg ttgctggacg
    11101 aggtcacgat gaggctccgg aggtttggct gggggtgggg caagcgtagc cgggcggccg
    11161 ggaacggctg tacgggcgag gctgcgggcc ctcccgggag cggtcgcgga cggaagcgga
    11221 atcccgtcca ccatttgtct caataaatgg gaccgagttg tccgtgccct tcggccgacg
    11281 gttaacctgc cagcatggca ctcggaatcg cttccaccag aactgaccgc gcgctgacgg
    11341 tccgcgagct tctggcggcc ggcaagcgat ccttctcctt cgagttcatg cccccgcgca
    11401 ccgaggtcgg cgagcagcgt ctctgggacg ccatccgccg gctcgaaccg ctcgacccca
    11461 acttcgtctg catgacgtac ggggccggcg gctcctcgcg cgagcgcacc gtcaacatgg
    11521 tcggccggat cgccaccgag accaccctga cgccggtcgc ccacctgacc gccgtcgacc
    11581 actcggtcgc cgagctgcgc aacatcatcg gccagtacgc cgaccagggc gtgcgcaacg
    11641 tcctcgcggt gcgcggcgac ccgcccggcg acccgatggg cgagtgggtg aagcacccgc
    11701 agggggtcac ctacgcgtac gagctggtcg agctgatcaa gggcatcggc gacttctgcg
    11761 tgggcgtggc cgcctcgccg aacatgcacc cgcgctcgac cgactgggac gaggacatcc
    11821 ggcacttcgt ggcgaagatc cgctccgggg ccgactacgc gatcacccag atgttcttcg
    11881 aggtcgacga ctacctgcgg ctgcgcgacc gggtcgcggc ggccggctgc gagacgccga
    11941 tcatcccgga gatcatgccg gtcaccaacg ccaagcagct cgaccgcttc ccgcagctga
    12001 gcggttcggc cttcccggcc gagctggagg cccggctgcg cgccgccatc gacgacccgg
    12061 cggcactgcg cgaggtcggc atggagcacg ccaccgcgat gtccgagcgg ctgctcgccg
    12121 agggtgcccc cggcctgcac ttcatcacgc tcaaccactc gacggcgacc ctggagatct
    12181 accagaacct cggtctgcac cagcgctgag ctgcgccgcc ggcccggccg ggccggcggc
    12241 cgcaacggcc cggaagtggt cgccccgggc gggaacgcga tgcggtaccc gggccgttga
    12301 accggtacag tcgccgcaca cgcgcggcgc gcgcgggcac gcgactggag gtagcgggcg
    12361 gatgggcatc ggatacctgc tgctgtacgc cgcgttggcg gtggtggcgc tctggctggt
    12421 ggccgagctg ctgctgcaga accgggcccc ggtgcactgg cgcgccctcg ccctggccgg
    12481 cttcctcgga gtgcccgccg ggatggcggc cggctccgtc gtggtgatcg gtgcgggcgc
    12541 ggccctgttc gcggtcggcc agaccctcgt caccctctcc gtgaagcgcg gctacgcggc
    12601 cggctggtcg ctgcgcaccg ccgacggcgg cctgcccggc ccgctcgcca aggtgccgct
    12661 gctcggcgcg ctgaccggcg gcgcggcggt ggccaccgcg gtggcggccg accggatcgg
    12721 cacggtcagc gcggtcgagg agagccccga gccggggccc gcggacgagg acgtcccggc
    12781 cgtcgagcag accgcggcct tcgagatgca ggagatcgcc gcggacgacg gcgtctacgc
    12841 gcccgcctac tacgagcagc agcagcccca gcaggttcag caggcccagc cggacccgta
    12901 cgccgaggcc taccaggccg gctacgaccc cgcccagcag caggccgcct gggaccagaa
    12961 cgcccagcag caacagcagc agtggcagac ccagcagcag ccggccttcg cctacgacca
    13021 gggctacggc ggctaccagc agcaggccgt ccagccggac cagtacgcgg cctaccagca
    13081 gcagcccgac gcctacggca cctaccagca gcagtccggc cagcagcagt acggctacga
    13141 ccagcaggcc cagcagcaac agcagcagtg gcagccgcag caggaccagc agcagggcat
    13201 cccgcagcag ccgcagtacg accagtacgg ctaccagcag cagaacacct ggcagcagca
    13261 gggctgagcc cccgcggccc ggtcggcccc cgtgcggccg gtcgccccgg tcaggccggg
    13321 ccgatgaggt tggccgcgat gcaggccgac atgccgaccc gggccagccc gccaccgggg
    13381 tgggcggcgc cgccgaccag gtagaggccc gggacggggg actcgttggc gtactgcagc
    13441 cagcgcccgt cgccgccggc cagggcgggg agggtgacgg cacccatgaa cgcaccggtc
    13501 tcccggcggg tgtcctcggg agtgcggacc acccgccaca ggacgcgctc gcgcaggccg
    13561 aggccggccg cgtcgacgtg gtccagcaag cggtccgcgt agcgctcggc caggccgggc
    13621 tccgtccagt cgacgtcgcc ctgggccggc accgtcacgg tcagcaccac gctctcgtgc
    13681 ccgtcgtccg gtcgcagcga cggatcgtcg gggcgcagga cctcgaccgt cgggcgctcg
    13741 cagaggccgg cgctgagcgt cagggcgttc cactcggccg ccgggtcggc ggcgtgcacc
    13801 acggtgcggt gcacggtgcc ctccggccgg gccccgcgca gtgccagcag cacgcggaac
    13861 cgccccttgg gctcctcgtt ctgccgcgcc cactcgttcg ggtcgccgtc gcccggccac
    13921 tcggcgacgc gccggcggaa cagctcccag gcgtccatcg aggagaccac caggtcggcg
    13981 tcgatccggc cgtcggcggt gtcgacgccc acggcgcggc cgtcctcgac cgccacggcg
    14041 gtgacctcgg taccgaagcg gaagtccacc ttgcgctgct cgcagcgccg gtacaccgcg
    14101 tcggccagcg cgcggacgcc gcccttgacg taccagacgc cgaaggactg ctccatgtac
    14161 ggcagcacgg tggcgctcgc cggggcggtg tccgggtgga ggccgtagcg cagcgcgtac
    14221 tcgttcagca gcgcggtcag gccagggtgg ccgtcgagac cgtgggcggc cacgccggtg
    14281 agcgtccagg gcgcgggccg gaacagccgg gacagcaggc ccttgcgggg cggcgccggg
    14341 tacgggtcgg tgtgcagcgg cgtcgggtcg gccgggagcg gctcctccag cagcgggcgg
    14401 cgggtggcct cccagaccgt gcggccgtgg ttcatcacct cggcccagcg cgcgcccgag
    14461 cccgcgccga aggcggcgtc cagcgcctgg accacgccgc cgcgggaggc gttgggcagc
    14521 accaggtcgg tgccgtcggc gaacaggtgc cggctctccg gctcgaccgg ggccagcttg
    14581 accagctgct ccagcggctc cttgccggtc ttcagcgcga ggtcgcggta gacggccggg
    14641 agggtgagca gcccggggcc ggtgtcgaag gcgaaaccgt cgcgttcgta ccggccgacc
    14701 atgcccccgt acgtcgcgcc cgcctcgcag accgtcaccc ggtgtccgag ggtcgcgagc
    14761 cgggaggctg ccgcgagccc gctcattcct gcgccgatga tgacgatccg tgccatggcc
    14821 cgatcctatg gctgcgcgga gtacgccccc gccgccggct gtgcccggcc cgccaggcgg
    14881 gccgccctgc gctcgcggcg gcgggcgcgg aagcggcgga tgcggttgac cgcgaaccgg
    14941 accagcagca ggccggcgat cagcagcgcg gcggcgatcg aggcggccag ccacgggtgg
    15001 aagatcgcca gggtgaccag gccggccacc gagaggtcct cggcgaggct gaccgcgatg
    15061 ttgctggccg gctcgggcga ggtgttgacc gccatccgca gcgaggcctt caccagatgg
    15121 ctgaccagcg ccgtggtgcc gcccaccgcg ccggcggcga cctcgggcag cgaacccggc
    15181 tcggcgctcg cgatcagcgc gcccaccgtg gccccggcga tcgggcggat caccgtgtgg
    15241 acggcgtccc agacgctgtc cacgtacggg atcttgtcgg ccaccgcctc cagcaggaag
    15301 agcacggccg ccgcgaccag tacgtcggtg cgctccagcg cgggcggcac cgagccggcc
    15361 ccggcgaacc ggcccagcag gccgagcagc agcaccaccg cgtacgcgtt gatcccgctc
    15421 gccagtccgc tggtgaagat cagcggaagg atggtcatcc gttcctcctc ggagtgcccg
    15481 ccgggaccgc ccggctcgcc gtaccgtacc gggacgcccg cggaccgccc tccggttccc
    15541 ggcccgggcg gactgagtac ggatactcag aaacacggtt gagtacctga gcggatggcc
    15601 tccgacctgc gcagacggga gagtggtggc accgggacgg cggcgcgtcg ggcgctgccg
    15661 gaccggtacg gcggacaggt ggggtccgcg ccggtcacgg ggggccggcg gacgccaccg
    15721 gcgggtccgc accggagccg gtcgtaggcc gcgcaccgcc gacacggggc ggcggagcgg
    15781 ggccaggggg gaccggccac cggggactgc ggggcgccgc ctacgggggg acggcgctcc
    15841 ggcgggtgcg gggcggtgag cgcgggccgg cgggggagcg gccggtgagc accgcccgca
    15901 cgcatgcccg acgcccggac ggacgggcga cgcctccggg ccgcattgtc agtggctccg
    15961 ttcacgatgg agacgcacgg accgtccggc ccgtgcactg cctcggaacg ggggagacca
    16021 tgaccgtcag ccgtcctgag cccgtcaccg cccgcctcca ctccgccgcc caccggccga
    16081 cgccacaccg gtcggagggg caccagcccg gtacccacgc gcccgccgcc ggggacgtcc
    16141 acccggtgct gcgccgggtc gccgccccgc ccgccgcgct cgacctgctc gccgacgcac
    16201 accgcacgct cacccggtcc cgctccctgg aggacccgct ggagcgctac gccgccgccc
    16261 acctcgccgc gctgcgcacc gtggcggcgg tgctcgccgt ccggggccgg ccggagaaga
    16321 gcccccggcg gcgccgggcg atccgcagtg cctgggaggt gcttccagag atggcgcccg
    16381 agctcgccga gtgggcggtc tacttcgcgg ccggcgcccg ccgccgggcc gccgccgagg
    16441 ccgggatcag gggcgccgcc tcggcccgcg acgccgacga cctgatccgc aactccgcgc
    16501 tcttcctccg cctggtcgag cggctgctcg gcctgcaccc ggtgcggccc gcgccgcggc
    16561 tcccgccgga cgacggcgac gccggccgca cccccggtcc cgggggtgac cgggggcggg
    16621 cctgaggctg gcctgaggcg gccgggcggt gcggcccggc cgcccgcagt ggcccgtccg
    16681 ccggcccggt ctaaggtgga ggcatcctga tcgatctgca cgtgccgagg agtcccgcct
    16741 tgtacccgac gcgtccccgc agcgccctgc gtaccgccgt ggtctgggag gtggtgcggg
    16801 ccgccctgga gaagcgggcg gccgagctcg accggccggt gctggacgtg gtcgacaccg
    16861 gcggcggcac cggcaacttc gccgtgccgg tggcccggct cggccaccgt gtcaccgtgg
    16921 tcgacccgag ccccgacgcg ctgttcgcgc tggagcgccg ggccgccgag gccggtgtga
    16981 ccgacctggt ccgcgccgtc cagggcgaca cccagacgct gcccgagctg gtcgcgcccg
    17041 gcaccgtcga cgcggtgctc tgccacggcg tgctggaggt cgtggacgac ccggccgagg
    17101 cgctcggcag cctggccgac accctgcgcc gcggcggttt cgtcagcctg ctggccgcca
    17161 accgcaacgg cgccgtgctg gcccgcgccc tcggggggca cttcaacgat gcccggacgg
    17221 tactggaggc cgccgacggc cgctggggcg acaccgaccc gatgccgcgc cgcttcaccg
    17281 gtgaggagct cgaccggctt gccgtcgacg ccgggctgcg ggtggactcg gtgcacggcg
    17341 tacgggtctt cgccgacctg gtgccgggcg tcctggtgga cgccgagccg ggtgcgctgg
    17401 acgcgctgct caagctggag gaggcggccg ccgagcagcc cgccttccac gccgtcgcga
    17461 cccagctcca cctgctggcc accctggcct gaccgggcgg tccgccaccg ttctccggcg
    17521 ggcctcctcc ctctctcctc cgaagctccc caggtcccgg ccgattccac ccggtcgggc
    17581 acttgtccgg gccccaccgc gttgagccca gtgcggccgg ggatggcccg gagtggcccg
    17641 gcccgtgcgt ggccgaccac cccgcaacgg gcccgtggac cgtatgatct gggtaaagcc
    17701 ggaaagcatg acagccggac gcttggggca tatggacgac acgggcccgg gcccccgcac
    17761 aggcgtccga ccgcgtgttc tcaaggctga ttggacttgc ctccccgacc ggggcggcgg
    17821 accggtcgca cccgcgaccg acgagtagga ggactccgtg ccgctctcgg agcacgagca
    17881 gcgactgctc gaccagatgg agcgagcgct gtatgccgaa gatcccaaat tcgcgtcggc
    17941 gcttgaggga accgggctgc gcacctacac ccgtcgccgg gtctatctgg ccgtcggcgg
    18001 cttcgtggtg ggtatcggcc tgttgatggg cggcatggtc gtccccgacc agatctgggt
    18061 cagcgtcgtc ggcttcctgg tgatgctggg gtgcgcggtc ttcgccgtga cgggctggcg
    18121 ccgtggtccg gccggccagg cgtccgggcc ccgtccggcc gccgccccgc accgcaaggc
    18181 cgggatgatg gaccgggtcg agcagcgctg gcagcgccgc cgggacgagc agaccggcgg
    18241 gttctgagcc tgcggcacga aggctccggg caacacgcct ccgggcacgg gcctgcggat
    18301 cccaccgcac gaacgccgag agggcgggca gtcgatccga ctgcccgccc tcggcgtttc
    18361 ccacctcagg acgccgtgat caggaagccg tcccgtccgt gccgccccgg cgccgcagcc
    18421 ggtcccagag ccggcggacc ggaccggtga ccgcaccggc cacccgggcc gcccgccggc
    18481 gcaccgcgag ccgcacgccc agcaccgcgt cggagagctt ccaccagagc tgcgccgagg
    18541 acggcggcag caggaccgcc ctggtccgcc cggcccggtc cgtgccggcc cgcaggccgt
    18601 cccgggcggt ccggacgtcc gccgccagcg gcgccgacac ccgggcggac cgggcgtaga
    18661 gcacccgctc ggtggccagc gccacccggc ctgcggcggc cgccgacgcc tcgtccagct
    18721 cggcggtctc ggagatccgg cgggcggcgg cgcgcggggt gcgcgactcg tccggcggga
    18781 tgccgaggtc ccaggcggag tcgatcagct cgtcccaggc ggccagcacc tgctcgtcgg
    18841 tcagctccgc cgggccgtca ccgccgggcc ggcgccgccc gcccgcgccg agccgccgac
    18901 ggcgcagcag cgtccgccag agcatcgggg tgagcagcag cgcgatcacc accaggaccg
    18961 cggccagggt ggacagcacc tgccaggaga gcagccagga gtcctcccgg gcgccggcgg
    19021 accccttctt ctggtccccg cagtcgcccg tccggcgcag cttcgggtcg cagtcgctgc
    19081 tgcgggaggg caccgcgacc ggcgcggtgc tctgtgcggc ggcggtgggc gcggtggtcg
    19141 gcgcgctggt gggcgcggcg accggctcgg tgtagcgggg agccaccccg acgcccttgg
    19201 tgggctcgaa gcgggtccag ccgaagccct cgaagtacag ctcgggccac gcgtggtaca
    19261 tcagcccgtt gaccgagtac cggtcgccgc ccttggcgtt gcccggcgtg aagccgaccg
    19321 cgacgcggga ggggatgccc agggtgcggg ccatcgccgc catggtggag gcgaagtgca
    19381 cgcagaagcc cttgcggttg cgcaggaact ccacgatcgc gtcgttgccg gtgccggact
    19441 tgatctgggt ggtgtaggtg aagtcggggc cggtgaacca gtcctggagc gccagcgcct
    19501 tgtcgtacgc ggtgggcgcc ctgctggtga ccgcctgggc ctgctgccgg acgacggacg
    19561 gcaggtcccc gggcaggtcg gtgtagtgcc cggcgatctg cggccgggcg ggcagcgcct
    19621 ggcgcaggtc ctcggcggtg ggccggacgt cgtacgcggt gacctggtag tgcaggccct
    19681 tgatcgcctt ctccttgccg ccggccggct ggacggtgcc ggtgagggtg tccaccctcc
    19741 agctgccggg gttcgggacg gtggcgctct tggccgggta gggcatcggc agccaggcgg
    19801 agtccaggtt gttggtgacc tggaagtcgc ccgggaccgt cgggacgccg aggtcgcgca
    19861 gcccctccgg gggtgcgaag gtgcccttga agtcggtcgt gccggggctg ccgagcttcc
    19921 atgcggcgcc gtcgaacacg tccagcgaac cggtgcgcag gtaggcggtg tccgcgaggc
    19981 tgctgtccat ccggtaggtg agcagctcga tgtcgctggg cttggtcagc gcggactcca
    20041 gggtgaccag cgggtcgagg ctggtgacgc ccccggcgcc ggtgccggcg gcggtgccct
    20101 tggggccggt gtggatcagg ccgccgtccc agcgcggcag gaacgccggc accagcagcg
    20161 ccagtgccag cgccaggacg ccgacgcgct ggccgctgag gctgagcgtg ccgccctcgc
    20221 cgccgcgcga ggtgccgcgg aagacccggc cccagcggga gacgcggtcc tggccctcgg
    20281 cgaagagcag taccaggtag ccggtggagg cgagcccgaa ccagacccag ctgccccggt
    20341 cgcccgccag tccgtttccg acggagtaga gcgccagcag cggcagtccg gccagcgccg
    20401 agcgccggta ggtcaccgcg acggtgtcca cggcgatggc gatcagcccg acggaggaga
    20461 ccaggatcag ccgcaggccc gggttgggcg gggccgggat ggcgtactcc cggatgtcgt
    20521 ccagcccgtg gccgaggacc tggccgaggg tgcgcaccga ctcggggccg ggcaccatgc
    20581 cgccgaagcg gttggtggcg ctcgcgaagc cgaccagcag caggacgaac aggacgagca
    20641 gctgtccgag cggcaccgtc cagcggtaga agggcgtccg gcgcaggccc gcgccggacg
    20701 cggcgaccgc gaggaccacc agcagggcgt agacgatcca gctcttgccg gtgagcagcg
    20761 gggccaggca gagcgaggcc agggcggttg ccagcgccga gtacacggtc agtttggccc
    20821 gggtggtcac gcgccggcct cttctcggta gggggaggac gacccggccg cgtcggcggc
    20881 ctgccacagg tcggggacgg aatcaccggc gcggaccggc aggaccgtcc agccggcctc
    20941 gcgcagctgc cggacgcggg cgcggaactc gtcgccgccg gtgtccgggg cgagcatccg
    21001 caggccgctc caggtgccgg agtcgagcag gaagaccacg gcgccgccgg tgcggttgcg
    21061 cagccgggcc agccgggcgg tctgcgcctc gtcgaggtcg ccgagga
//
