LOCUS       NZ_CP026498            22520 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. CB01881 chromosome.
ACCESSION   NZ_CP026498
VERSION     NZ_CP026498.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB01881
  ORGANISM  Streptomyces sp. CB01881
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     A 3-hydroxy-3-methylglutaryl-CoA synthase gene based probe for the
            discovery of the acyltransferase-less polyketide synthases
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) Xiangya International Academy of
            Translational Medicine, Tongzipo, Changsha, Hunan 410000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002953255.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 02:39:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,978
            CDSs (total)                      :: 7,904
            Genes (coding)                    :: 7,565
            CDSs (with protein)               :: 7,565
            Genes (RNA)                       :: 74
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 124 of 339
            Pseudo Genes (incomplete)         :: 251 of 339
            Pseudo Genes (internal stop)      :: 10 of 339
            Pseudo Genes (multiple problems)  :: 45 of 339
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:44:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6998518
            Orig. end                         :: 7021038
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026498.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22520
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="24"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22520
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22520
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12520](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12520
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(13..22)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    72..87
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    complement(257..271)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.96"
                     /tool="antismash"
     gene            complement(406..996)
                     /locus_tag="C2142_RS20400"
                     /old_locus_tag="C2142_20435"
     CDS             complement(406..996)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554065.1"
                     /locus_tag="C2142_RS20400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20435"
                     /product="HhH-GPD-type base excision DNA repair protein"
                     /protein_id="WP_148643985.1"
                     /transl_table=11
                     /translation="MNVTVRLAQQPEADALLGRSALAALVGMLLDQQVPMEWAFTGPLT
                     IAQRLGRDDLDAHEIAVYSPEEFVALLSEKPAVHRYPVAMAKRVQQLCQFLVAQYDGDA
                     TGIWRDAKSGRELLSRLNALPGFGKQKSQIFLALLGKQYGVQPEGWREAAGTYGEEGSY
                     HSVADITSPESLEKVRAHKQEVKRAAKEAKAKA"
     misc_feature    complement(1314..1329)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.96"
                     /tool="antismash"
     gene            1382..2296
                     /locus_tag="C2142_RS20405"
                     /old_locus_tag="C2142_20440"
     CDS             1382..2296
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014137142.1"
                     /locus_tag="C2142_RS20405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20440"
                     /product="hypothetical protein"
                     /protein_id="WP_148643986.1"
                     /transl_table=11
                     /translation="MHIHRTELVRNFTVLPNGLLQDRRLSYTARGLLADLLSRPDGWRE
                     DGRHMADTSPQGRGPVRRALKELTEAGYYRVEKIRMPDGRIRSEAHVYDTPQRALPGAT
                     RPAAGEAGAGSAGVPVVKNRKQEPTLPAELADEADEAGVLGVVGASDEQVREAVAVLFR
                     AIRPEPRLRLGEPEAVALAPLVAQWLERGSTAADLTRALLPALPVPMHSAAGVLRYRLV
                     QKMPPVPEAGPPPVARLAECAECRDPVPQPGICGACAGVERRPAPAAGGAAVTVGGVAR
                     ARAILLAGKAALAGPRPAVAPAG"
     gene            2351..2545
                     /locus_tag="C2142_RS20410"
                     /old_locus_tag="C2142_20445"
     CDS             2351..2545
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010032276.1"
                     /locus_tag="C2142_RS20410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20445"
                     /product="type II toxin-antitoxin system VapB family
                     antitoxin"
                     /protein_id="WP_148643987.1"
                     /transl_table=11
                     /translation="MSRTVIDLDDELLADVAKALGTRTKKDTVNTALREVLENRKAAPA
                     LAGLRATTDEGCGLPGVTS"
     misc_feature    2626..2641
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            2752..3525
                     /locus_tag="C2142_RS20415"
                     /old_locus_tag="C2142_20450"
     CDS             2752..3525
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669369.1"
                     /locus_tag="C2142_RS20415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20450"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_148643988.1"
                     /transl_table=11
                     /translation="MQNILEFPEVLRLIEDRSAAFRAAIASAPDLDVQVPTCPDWTLRE
                     LAQHLGDGRRRQAAIVAAGPGAEPPARTDPKGAPTAPRDREALDAWLAESTELMLDAMR
                     EAGPDRGCWTWWGRSQAPETSGAVARHQIQEIAVHTYDVQLTQGAAQPLPTDVAVEGVD
                     EFLTTVSATTVPWPFKPATIDLHTTEGRSWRLTLNADGVRCDDLAADAEPGDMVMRGAA
                     SELVLYFYDRIPLDSLENTGDTEPMEQLADWDPNA"
     gene            complement(3823..4254)
                     /locus_tag="C2142_RS20420"
                     /old_locus_tag="C2142_20460"
     CDS             complement(3823..4254)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS20420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_20460"
                     /product="hypothetical protein"
                     /protein_id="WP_148643989.1"
                     /transl_table=11
                     /translation="MAPIPNGPYGIAKRGEQYLTLQDEKAPAVVLPPTGQPGEQEWHVG
                     GLSNGNVTIKNLRHGTYLSFDGVPEINKMLRGSSQATEWQLRQSAEPFMFHVVVPGGPV
                     DGVELVVDLSLLRIFPPMTALRPLEPENLGQAWIFEFHE"
     misc_feature    complement(4248..4258)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(4415..4627)
                     /locus_tag="C2142_RS20425"
                     /old_locus_tag="C2142_20465"
     CDS             complement(4415..4627)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179301.1"
                     /locus_tag="C2142_RS20425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20465"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_148643990.1"
                     /transl_table=11
                     /translation="MSQALDLTNAAWRKSSYSGGNGGECVEVAPGFPGLVPVRDSKDPS
                     GPALTFTPTAWSAFLTAVHTGEFDA"
     gene            complement(<4662..5456)
                     /locus_tag="C2142_RS40105"
                     /old_locus_tag="C2142_20470"
                     /pseudo=""
     CDS             complement(<4662..5456)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="C2142_RS40105"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20470"
                     /product="helix-turn-helix transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MARRKVDPGDRPRTWGDELAHWRQAAGLRQDEVAGLVNIHQTRVS
                     QFELSKAPPTLKDAEMFDRALGTGGQLVRSYELIAPYLHDYHPDWFQEFAKSEAKAVVI
                     RQLQTGRISGLLQTERYMRALFVEENEGLAPNEIDGMITGRMERQRLLLLPDEAPLIIS
                     VLEQATLERVIGGPDAMAEQLQHLIDMMSRPNVIIQVLPYRAATRAWMPGMVLLEMPDG
                     RRRVYSESLNRGHFIDDAAEVRRWAAHYDRTRAAALSDSESMQ"
     gene            5628..5954
                     /locus_tag="C2142_RS20430"
                     /old_locus_tag="C2142_20475"
     CDS             5628..5954
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS20430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_20475"
                     /product="hypothetical protein"
                     /protein_id="WP_148643992.1"
                     /transl_table=11
                     /translation="MTNLIIERNFPPCLCAHCNDAVPEARLNGDDLAPAAPAAVPGAVP
                     PVLPYLPVRRGEAVFDVRSGRWGAFMAVHQGVVFLRPFGGGVEWDADPRWLSQHKPPKS
                     SVVS"
     gene            6003..6209
                     /locus_tag="C2142_RS20435"
                     /old_locus_tag="C2142_20480"
     CDS             6003..6209
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009066917.1"
                     /locus_tag="C2142_RS20435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20480"
                     /product="hypothetical protein"
                     /protein_id="WP_148643993.1"
                     /transl_table=11
                     /translation="MTADDRRRAADAFDDFQATLAAAGLTLPSAGVDWRSAQTTGVVLI
                     DLGAVRADVVERLTDLVRRGLRR"
     gene            complement(6227..6952)
                     /locus_tag="C2142_RS20440"
                     /old_locus_tag="C2142_20485"
     CDS             complement(6227..6952)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661295.1"
                     /locus_tag="C2142_RS20440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20485"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_148643994.1"
                     /transl_table=11
                     /translation="MPGGRLTQQERQQIALGVGDGLAYAEIARRLDRPTSTITREVMRN
                     GGPTGYRADLAHRATERRAHQRRQTAPRQPQAPEQAHGRDPEAVREFEETFTTVFMASG
                     TPKMMARVLAALCTNDAGSLTASELAQRLQVSPASISKAVAFLEEQGLVRRERDERRRE
                     RYVVDDDVWYQSMMASVRGTTLVAETARQGVKVLGPDTPAANRLENVARFLDFVSESIA
                     RAADQAREVLHLKPEEGRG"
     misc_feature    complement(7055..7071)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    7130..7150
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    complement(7131..7151)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.37"
                     /tool="antismash"
     gene            7177..7842
                     /locus_tag="C2142_RS20445"
                     /old_locus_tag="C2142_20490"
     CDS             7177..7842
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143411.1"
                     /locus_tag="C2142_RS20445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20490"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_148643995.1"
                     /transl_table=11
                     /translation="MQKFQTPAPITAVLDIPAGRIQVIAAERPDAIVEILPANPSKKRD
                     VQAAEQTTVAYADGVLRILTPPAKNQLLGPSGSLEVTVKLPAGSRIEAKTACTEFRAVG
                     RLGDIGFEGAYRQIKIDQAAGLRLTAVDGDVEVGRLGGPAEITTARGSIRIAEAASGTV
                     VLSTQSGDISVGAAAGVSASLDAGTGYGRITNALKNDGTPGLDIRATTSYGDIDARSL"
     gene            7865..8827
                     /locus_tag="C2142_RS20450"
                     /old_locus_tag="C2142_20495"
     CDS             7865..8827
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155601.1"
                     /locus_tag="C2142_RS20450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20495"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_148643996.1"
                     /transl_table=11
                     /translation="MTNLAIAANGLRKSYGDKTVLDGVDLAVPEGTIFSLLGPNGAGKT
                     TAVKILSTLISAGPGSGDIHIGGHNVATNPQAVRAAIGVTGQFSAVDGLITGEENMLLM
                     ADLHHLSRSEGRRTAAALLERFDLVEAAKKPASTYSGGMKRRLDIAMTLVGGPRIIFLD
                     EPTTGLDPRSRHNMWQIIRELVSDGVTVFLTTQYLEEADELADRIAVLNDGRIAAEGTA
                     EELKRLVPGGHVRLRFTDPAAYQRAALALDGATRNDETLSLQAASDGSQRELRSILDRL
                     DSAGVEADELTVHTPDLDDVFFALTGGARIPSQTKETVR"
     gene            8824..9615
                     /locus_tag="C2142_RS20455"
                     /old_locus_tag="C2142_20500"
     CDS             8824..9615
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121788.1"
                     /locus_tag="C2142_RS20455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20500"
                     /product="ABC transporter permease"
                     /protein_id="WP_148643997.1"
                     /transl_table=11
                     /translation="MSSLSLALRDSSTMLRRNLLHARRYPSLTLNLLLTPVMLLLLFVY
                     IFGDTMSAGIGGGAPDRAAYIAYVVPGLLLMTVGSTVIGTAVSVSNDMSEGIIARFRTM
                     AIHRPSVLVGHVVGSVLQSVMSVVLVGAVGVAIGFRSTDATVLEWLAAFGLLVLFATAL
                     TWIAVGMGLVSPNAEAASNNAMPLILLPLLSSAFTPVHSMPGWFQPIAEYQPFTPAIET
                     LRGLLLGSEIGNNGWLAVAWCVGLAVLGYFWSTSTFNRDPK"
     misc_feature    9841..9861
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            10001..12520
                     /locus_tag="C2142_RS40110"
     CDS             10001..12520
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383771.1"
                     /locus_tag="C2142_RS40110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_241002691.1"
                     /sec_met_domain="T1TS (E-value: 2.7e-85, bitscore: 286.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPSFYVPHPARLNPHLEEARTHSTAWAREMGMLEGSGIW
                     DQADLEAHDYGLLCAYTHPDASAEVLSLVTDWYVWVFFFDDHFLEVFKRTNDREGGKAY
                     LDRLPLFMPADPSTPMPEPTNPVEAGLADLWRRTVPAMGEDWRIRFAESTRNLLNESLW
                     ELANINAGRISNPVEYIEMRRKVGGAPWSAGLIEYAANAEVPQEVSGSRPLRVLMDAFS
                     DGVHLRNDIFSYQREVEDEGELSNGILVLETFLGCSTQEAAEAVNDLLTSRLQQFENTV
                     FTELPSLFAETGLDPVGCAKVLAYVKGLQDWQSGGHEWHMRSSRYMNDGGAAAGSAGGN
                     WWDQYAIGGIGTSALDVLRTGPGRALPGGMGELGSLSGAPGINAPGINTLEGTPGSPGG
                     VDPAVRRARSHAHVPFQHVGPSRLPEFKLPFSVDLCKHLDTSRRHTVEWAGRMGMLEAQ
                     PGVPGSDVWSAGTAFDYDLPLCAAGIHPDATAEQLDLTSDWLTWGTYGDDYYPAVFGRT
                     RDLAGARLLTARFSEFMPLDDGPVPEPANALERGLADLWERTAGPMAADARQKFRVAVE
                     SMVQSWVWELDNQAQNRIPDPVDYIEMRRRTFGSDLTMSLCRLAHGESVPSGVYESGPM
                     RSLENAAADYACMMNDLFSYQKEVEYEGEVHNAVLVVQNFFNCDYPAAVRIVDDLMHSR
                     VEQFQHVARNEFPVLYDDFDLGPEGRAMLDGYVKELENWLAGILIWHRGCKRYTEDDLK
                     RHFGREELPEAPAAVDDALLGPKGLGTSAARLVVAAAPAGAAAGAAEGAPRPGLVPSGP
                     AGFGTAGARAPFAAALPAPVGVAGVAG"
     gene            12722..13522
                     /locus_tag="C2142_RS20465"
                     /old_locus_tag="C2142_20510"
     CDS             12722..13522
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662971.1"
                     /locus_tag="C2142_RS20465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20510"
                     /product="VOC family protein"
                     /protein_id="WP_148643998.1"
                     /transl_table=11
                     /translation="MAVLPEGTPCWADAMFADLDGAKAFYGDVLGWTFGESSSEFGNYT
                     TAYSDGKAVAAIVPPMPGADAPPSAWCLYFASPDAAATAEGIRANGGEVLMGPMQVGDF
                     GTMAIAKDPGGVAFGVWQAGSHEGFEKQGAPGAYTWAEVLTREPGKADGFFPAVFPFTT
                     KKMESGEMDYKIFHVEGQPVLGRMKMGPEDLPPEAPSYVSVYFAVNDCDVAIARITERG
                     GKLYAGPMDTPFGRFAAVGDPQGAAFGIIDLGRTSGEMPVMADA"
     gene            13554..14042
                     /locus_tag="C2142_RS20470"
                     /old_locus_tag="C2142_20515"
     CDS             13554..14042
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004000253.1"
                     /locus_tag="C2142_RS20470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20515"
                     /product="DinB family protein"
                     /protein_id="WP_148643999.1"
                     /transl_table=11
                     /translation="MSSERADLLQTLDKHRGFLRHTVRDLTDEQAARRTTVSELCLGGL
                     IKHVMGVETRWMRFAVGGADAMNSEPVDWEGQFRMADGETLESLLAAYERVAHETDELV
                     STLPDLDRTHPLPQAPWFEPGAGWSVRRVLLHVIAETAQHAGHADIIRESLDGAKTMG"
     gene            complement(14070..14771)
                     /locus_tag="C2142_RS20475"
                     /old_locus_tag="C2142_20520"
     CDS             complement(14070..14771)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174934.1"
                     /locus_tag="C2142_RS20475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20520"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_148644000.1"
                     /transl_table=11
                     /translation="MPLAQLAALLADPTRAAFCTALLDGRAWTGGELARHAGVAPSTAS
                     EHLSRLIAGGLLAEERQGRHRYVRLAGPEAAALIEDLASFAESAPAKAPAKAPRNLRES
                     TRLSAEARARTCYDHLAGRLGVAVTDAVLARGLVADDAGLAVTGSGREWLAAAGIELPA
                     RAGRGGGRPLVRGCLDWTERRTHLGGVLGAALCRTALDRAWVERIGSGRALRVTADGDR
                     ALSELLGLRLA"
     misc_feature    14805..14819
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.02"
                     /tool="antismash"
     gene            14837..16246
                     /locus_tag="C2142_RS41995"
     CDS             14837..16246
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014177079.1"
                     /locus_tag="C2142_RS41995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_346766387.1"
                     /transl_table=11
                     /translation="MSTPSILSISGTSERSQERSLERSFERYDDVVDALAHPDLVPLPA
                     ASGPAGGVAWLRAAVARFSAGEEHAARRAMVEADLARLDPAALRVAAAAGFEPDARLRA
                     VRALAQGLGLAEPDAVAQAVSVVARAYFAEAPDDAEADAAVAWLLPRMAAGGGAEDGAS
                     VGVGVGGPVPEELAANRIGLLVQACDATATLVGNARRAGCRSAAGDAPGGEGLLDRGLL
                     DRTLRHDPSVPVMRRLAVRDAVVGGVRLPAGTRVVLDVAAAQQGAPGRPPLTFGGPPRV
                     CPGRTHALALAAGILHGASDPAGPTAADTPVTDGRDPGAVVSATVEHVLALAATWTEWD
                     GRPVAADGRTYTPHKAVRRVADHLLDHLAELEARLAGEATEPDHWHASAATTPADLAPF
                     TPADLDEARSRLTRLARIWARRLAALTPEQLDHSPGTGWTFRQLAFHVAESAYYADAVG
                     DLRAGAEGAAS"
     gene            16243..17037
                     /locus_tag="C2142_RS20485"
                     /old_locus_tag="C2142_20530"
     CDS             16243..17037
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554593.1"
                     /locus_tag="C2142_RS20485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20530"
                     /product="isocitrate lyase/phosphoenolpyruvate mutase
                     family protein"
                     /protein_id="WP_148644001.1"
                     /sec_met_domain="PEP_mutase (E-value: 2.6e-66, bitscore:
                     222.4, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPFAALHHRPGEPLLLPNAWDHASAAALAGQGFAAIGTTSLGVA
                     AAAGLPDGVAATRRETLRLARRLGRGRFLLSVDVESGFSDDPSEVADLAVELAGLGAVG
                     INLEDGRGDGTLAPVAVHAAKIAAVKAAAPDLFVNARTDTHWLGTADPGPETDRRLAAY
                     QQAGADGVFVPGLADPAAIEALAGRLAVPLNILHSPAGPPLGRLADLGVARVSLGSLLY
                     RAALAAAVQTAVAVREGGAGPMAGAVPAYGEVAGLHRDGGQG"
     gene            17158..17535
                     /locus_tag="C2142_RS20490"
                     /old_locus_tag="C2142_20535"
     CDS             17158..17535
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044128.1"
                     /locus_tag="C2142_RS20490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20535"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_148644002.1"
                     /transl_table=11
                     /translation="MGNRQLQEPTRLVLTALADAPRHGYAIVQEVLAISGGRTKLLTGT
                     LYTALDRLLQQGLIRIDQEEVVGGRLRRTFALTEDGRGVLAEETERLRAGVVEAERRLA
                     LGRRPGLQAGFVRLAPAGGAA"
     gene            17532..18527
                     /locus_tag="C2142_RS20495"
                     /old_locus_tag="C2142_20540"
     CDS             17532..18527
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS20495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_20540"
                     /product="hypothetical protein"
                     /protein_id="WP_148644003.1"
                     /transl_table=11
                     /translation="MSASSPQFGLPTRLPLLGLYPAKYRAANGAEIAAVLSESLEGADR
                     RTVLREWATVAAHAVRLRTRLSSSDPAGRFLAGAAPYLLAGGAGLAVVHLLLGLFLPDQ
                     FGDEGHPALRVAVGAVQTVPWILALLCAAGGRWGAARLLVLAGTLMRTAAAAAFFAHES
                     LALFQYLPLAGFWLLLSVLLLAPPDGVDHSRRARTEMVATALALALPMGALAMIWPWPD
                     EGLAADHVFSDANRTLLDVSTAWPAVVMSIALLLNLARRGVDRVRAAGVALAVLPWTAM
                     LAPPYYWRPPFDGHDLLRNLLVVLALLAFTATVAATRHRVRPSVEPVEPA"
     gene            complement(18636..20057)
                     /locus_tag="C2142_RS20500"
                     /old_locus_tag="C2142_20545"
     CDS             complement(18636..20057)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018853784.1"
                     /locus_tag="C2142_RS20500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20545"
                     /product="amidase"
                     /protein_id="WP_148644004.1"
                     /transl_table=11
                     /translation="MQDTIWTMTAAEQAAAVRSGEVSAVEVVDSHLARIAVVNPQVNAV
                     TQLLADRAREAAAATDRHRAAGGQLGPLAGVPFTVKESTPVEGVPTTFGVKRFRDLVAP
                     ADALPVARLRAAGAVPIGHSNMPTLILSGMHTRSELFGDTANPWDAGRTPGGTSGGDAV
                     AVATGMAALGLGNDSGGSVRIPAQFCGVTALKPSTGRFPADRRVLGPDDPGPATQFLVT
                     DGPLARSVDDLRLAYEVLAGSDPRDPWAVPVPVRGARLPGPVKVAVVADPGGHGVHPAV
                     RAAVGTAAEALRDAGYDVREVPDVPRLDEALEAYDRITVTEFAPSWPAVRGLLGEGGDR
                     FIGMMMERVRPATSDELVRLMGTWLNIRRSWAEFLDEYPLLLAPVFTEPPVGPGLESRD
                     RAGRDRVASAMRLCSVTSFVGVPGVAVPTGVTDGLPVGVQLVGRPFREDLCLDAAQAVE
                     DRLGVFTPVDPRSAA"
     gene            20220..20849
                     /locus_tag="C2142_RS20505"
                     /old_locus_tag="C2142_20550"
     CDS             20220..20849
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524655.1"
                     /locus_tag="C2142_RS20505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20550"
                     /product="TetR family transcriptional regulator C-terminal
                     domain-containing protein"
                     /protein_id="WP_148644005.1"
                     /transl_table=11
                     /translation="MPRQVDHEERRRVIAEAVCALADERGLEGVTVRDVADRAQISMGA
                     VQRCFRTKEEMLVFALAHVGERIGERVRARLVRTPAQSAATALGHAAAEVSLLGEEHRA
                     EARVWLAFVAQAVVSAPLAETLRAGYAPLEDAFARLIEEGAVRGAGEPAGEDAPLDARR
                     EARTVLALADGLTVHVLAGHLTPQEAGDVLHAHLARLWAGRQPPPA"
     gene            20993..21919
                     /locus_tag="C2142_RS20510"
                     /old_locus_tag="C2142_20555"
     CDS             20993..21919
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (14-305). E-value: 8.6e-53.
                     Score: 171.4. Matches aSDomain:
                     nrpspksdomains_C2142_RS20510_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383700.1"
                     /locus_tag="C2142_RS20510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_20555"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_148644006.1"
                     /sec_met_domain="ADH_N (E-value: 2.8e-08, bitscore: 32.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-15, bitscore:
                     56.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVIQKSFGGPEVLELVEAERPAPLGGEVLVRVHASGVNPVDVA
                     VRSGAYPLLGEPPYGVGWDISGVVEEAGPGARFKVGDEVFGMPFFPRAATGYADYVAVP
                     SRQVARKPATLDHVQAAALPLSALTAWQGLVDAAQLSEGQRVLVHRAAGGVGHYAVQIA
                     KARGAHVIALASESKHEFVRGLGADEVIDYRITDYTEVVRDVDVVFDSSSEGTRALSVL
                     RPGGTLVSIMEHWNQELAAKIEAAGRRFAGVSVEPDYASLEAIAALVDAGRIRPHVAET
                     FPLADAGKAHELVGSGRVQGKVVLTVA"
     aSDomain        21035..21907
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS20510_PKS_ER.1"
                     /evalue="8.60E-53"
                     /label="C2142_RS20510_PKS_ER.1"
                     /locus_tag="C2142_RS20510"
                     /protein_end="305"
                     /protein_start="14"
                     /score="171.4"
                     /tool="antismash"
                     /translation="LELVEAERPAPLGGEVLVRVHASGVNPVDVAVRSGAYPLLGEPPY
                     GVGWDISGVVEEAGPGARFKVGDEVFGMPFFPRAATGYADYVAVPSRQVARKPATLDHV
                     QAAALPLSALTAWQGLVDAAQLSEGQRVLVHRAAGGVGHYAVQIAKARGAHVIALASES
                     KHEFVRGLGADEVIDYRITDYTEVVRDVDVVFDSSSEGTRALSVLRPGGTLVSIMEHWN
                     QELAAKIEAAGRRFAGVSVEPDYASLEAIAALVDAGRIRPHVAETFPLADAGKAHELVG
                     SGRVQGKVVL"
     CDS_motif       21419..21481
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C2142_RS20510_0001"
                     /evalue="4.20E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="C2142_RS20510"
                     /protein_end="163"
                     /protein_start="142"
                     /score="25.6"
                     /tool="antismash"
                     /translation="GQRVLVHRAAGGVGHYAVQIA"
ORIGIN
        1 cgtcaccgtg ctggccgcct tcatggcggg tttctccggc ggggcgatct tcttcaaggc
       61 cgcgttcgtg gtggacccgc tggtcgagta cggggtgccg cgttcgtggt ggaactggct
      121 gggtgcggcg aaggccgccg gtgcggccgg cctggtggcc ggcctgttcc tgccggtgat
      181 cggggtgttg gcggcgatcg gcctggtgct ctacttcgcc ggggccgccg tcaccgtgat
      241 ccgggcccgc tcgtacgccc acgtcgtgtg gccgctgatg tacctggctc cggccgccgc
      301 ctcgctggtg ctgttcgcct gagacgcctg agccggccag aacggaggct ccccgacgcg
      361 ccggtcccgg cactcctcgt gagtgccggg accgggcggg tggggtcagg ccttggcctt
      421 ggcctccttg gcggcgcgct tgacctcctg cttgtgggcg cggaccttct ccagggactc
      481 cgggctggtg atgtccgcga ccgagtggta cgacccctcc tcgccgtacg tgcccgccgc
      541 ctcgcgccag ccctcgggct gcacgccgta ctgcttgccg agcagggcga ggaagatctg
      601 cgacttctgc ttcccgaacc cggggagggc gttgaggcga ctgagcagct cccggccgga
      661 cttggcgtcc cgccagatcc cggttgcgtc gccgtcgtac tgggcgacga ggaactggca
      721 gagctgctgc acccgtttgg ccatcgcgac cgggtagcgg tggacggccg gtttctcgga
      781 gagcagcgcg acgaactcct ccgggctgta cacggcgatc tcgtgtgcgt cgaggtcgtc
      841 ccgcccgagc cgctgcgcga tggtgagcgg accggtgaac gcccattcca tgggtacctg
      901 ctgatcgagc aacatcccga cgagcgcggc gagcgcgctg cgcccgagca gcgcgtcggc
      961 ctcgggctgc tgtgcgagcc gaacggtgac gttcatggga aagccctcct cggatgtgga
     1021 gactcgggtc gcggcccagt ctggtggacg gggcgggagg gggaggggtc aacacgccag
     1081 ggggtggtga ttccctggaa acgctgggtg gttcgttggc agagttattg cgtcgtcgca
     1141 cattgcgcgg agtattggtc tgctctgccc ggcgtgaggg ctgatcaatc gtgtccggat
     1201 cgatttgatt ggccggggcc ggttcaatca agtgcgggct ggaatggtcg attgacggcg
     1261 aaaatgtcaa cgggctttgt gtgcacggtt gttgtggtac gttccgtggc ctcatggaaa
     1321 aatagtcgac cccggcagcg cgccaacgct ccggggccag gcaccaggag tagagctcca
     1381 gatgcacatc catcgtaccg aactggtacg caacttcacc gtgcttccca acggcctgtt
     1441 gcaggaccgg cggctcagct acaccgcccg cgggctgctc gccgacctcc tctcccgccc
     1501 cgacggctgg cgggaggacg ggcggcacat ggccgacacc agcccgcagg ggcgcggccc
     1561 cgtccgccgg gcgctgaagg aactgaccga ggccgggtac taccgggtcg agaagatccg
     1621 gatgccggac gggaggatcc gcagcgaggc ccacgtctac gacaccccgc agcgggcgct
     1681 tccgggtgcc acccgtccgg cggccggtga ggcgggggcc ggctccgcag gcgtccctgt
     1741 agtaaagaac cggaagcaag aacccaccct ccccgcggag ttggccgacg aggccgacga
     1801 ggccggggtg ctcggggtgg tcggggcgtc ggacgagcag gtccgggagg cggtggccgt
     1861 gctgttccgg gcgatccgcc cggagccccg gttacggctg ggcgagccgg aggccgtggc
     1921 gctggcgccg ctcgtcgcgc agtggctgga gcggggcagt acggcggcgg acctgacccg
     1981 ggccctgttg cccgccctgc ccgtcccgat gcactcggcg gccggggtgc tgcggtaccg
     2041 gctggtgcag aagatgccgc ccgtccctga ggccggcccg cccccggtgg cgcggctcgc
     2101 cgagtgcgcc gagtgccgcg atccggtgcc gcaaccgggc atctgcggcg cctgcgcggg
     2161 agttgagcgg cgcccggcac ccgccgccgg gggcgcggcg gtcacagtcg ggggcgtggc
     2221 gcgggcccgg gcgatcctgc tggccggcaa ggccgccctg gcgggccccc gcccggcggt
     2281 ggcaccggcc ggttgaggca gcgggggcct atcacaggga tgagtactgc ctgatcgagg
     2341 aggtgggctc atgagccgga cagtgatcga tctggatgac gaactgctcg cggacgtggc
     2401 caaggctctc gggaccagaa ccaagaagga cacggtcaac accgctcttc gtgaggtgct
     2461 ggagaacagg aaggctgcgc cggcccttgc cgggctgcgt gccacaacgg acgaagggtg
     2521 cggattgccg ggagtgactt cgtaggccaa gcagcgagtt ggtagcgggc ctggtggttg
     2581 cgccggtgct cttggcccag atggcaggtc cagtagcggt cgaagccgcc gttggcgagc
     2641 agtgcacgga gtttcaggac ggcttcggcg ccggcgctcc gcccggccgt cgacgcgttc
     2701 gtccgacaaa ttcgctacct ggcggccgga gcaccgcgat acacaaccga cgtgcaaaac
     2761 atcttggagt tccccgaggt cctgcggctg atcgaagacc gctcggccgc gttccgcgcc
     2821 gcgatcgcgt ccgcccccga ccttgacgtc caggtcccga cctgcccgga ctggacgctg
     2881 cgcgaactgg cgcagcacct cggcgacggc cgccgccgcc aggccgccat cgtcgcggcg
     2941 ggcccgggcg ccgagccccc ggcgaggacg gacccgaagg gcgccccgac cgcgccccgc
     3001 gaccgcgaag ccctggacgc ctggctcgcc gagtcgaccg agctcatgct cgacgcgatg
     3061 cgcgaggccg gcccggaccg cggctgctgg acctggtggg gccgctcgca ggccccggag
     3121 accagcggag ccgtggcccg gcaccagatc caggagatcg ccgtccacac ctacgacgtc
     3181 cagctcaccc agggggccgc acagccgctg ccgacggacg tcgcggtcga gggcgtcgac
     3241 gagttcctga cgaccgtctc ggcgacgacc gtcccctggc cgttcaagcc ggcgaccatc
     3301 gacctgcaca cgaccgaggg ccgctcctgg cgcctgaccc tcaacgccga cggcgtccgc
     3361 tgcgacgacc tcgccgccga cgcggagccg ggcgacatgg tgatgcgagg cgcagcgagc
     3421 gaactggtcc tctacttcta cgatcgcatc ccgctcgaca gcctggagaa caccggcgac
     3481 accgagccga tggagcagct cgcagactgg gacccgaacg cgtagaacgc gcacttgtga
     3541 cgcatctgtc gatggtgcgc gcgctcctgc aggcgccact gggcccgggg ttgcggacat
     3601 cgcgcggctg cgggcaggct gcgggcctgc tgttcaaggg cgaagggcgc accggcgggc
     3661 ggctcgcgct cacttgggca gcatgccagg cgtacacctg gcaggggcgt ttcacagtcc
     3721 cggtgatcat gtgagtccgc aggccgtggc ggcgtgacga gtccgggccg ccgtcacccc
     3781 ttccacatgc gaggcggggc ggcggcggcc ggcgggtgag gcctactcgt ggaactcgaa
     3841 gatccaggcc tggccgaggt tctccggctc cagcggacgc agcgccgtca tcggggggaa
     3901 gatccggagc aggctgaggt ccaccaccag ttcgacaccg tcgaccgggc cgccggggac
     3961 gacgacatgg aacatgaacg gctcggcgga ctgccggagc tgccactcgg tggcctgcga
     4021 ggagccgcgg agcatcttgt tgatctccgg aacgccgtcg aagctgaggt acgttccgtg
     4081 ccgcaggttc ttgatggtga cgttgccgtt ggagaggccc ccgacgtgcc actcctgctc
     4141 accgggctga ccggtcggcg gcaggacgac cgcaggggcc ttctcgtcct ggagcgtcag
     4201 gtactgctcg ccgcgcttgg cgattccata ggggccgttg gggatcggtg ccatggcagg
     4261 tgtctcctcg ggaggggaac tcgtcggtgc ggtgctccag ccggagcgca cacacacgat
     4321 ccttgccgtg agaccgtgct acgcgcgatg ggctcgccca gcggtcgtcc gatcgggtga
     4381 cgtggaccgg ggacgggcgg gcgcgcggcg gctgtcaggc gtcgaactcg ccggtgtgga
     4441 cggcggtgag gaaggcgctc caggcggtcg gggtgaacgt gagggcgggg ccgctcgggt
     4501 ccttactgtc acgcaccggg acgaggccgg ggaatccggg ggccacctcg acgcactcgc
     4561 cgccgtttcc ccccgagtag ctgctcttgc gccacgccgc gttcgtcaga tcgagggctt
     4621 gggacactgt tgctcagtcc tctcatgatg cggtggatca gctgcatgga ctccgagtcg
     4681 gacagagctg ctgccctggt ccgatcatag tgagcggccc agcgtcggac ctccgccgca
     4741 tcatcgatga agtgacctcg gttcaggctc tccgagtaga cgcggcgccg gccgtccggc
     4801 atctccagga gaaccattcc cggcatccag gcgcgagtcg ccgccctgta gggcagcacc
     4861 tggatgatca cgttggggcg gctcatcatg tcgatcaggt gttgaagttg ctccgccatg
     4921 gcgtccggtc caccgatgac tctttcgagg gtcgcctgtt cgagaacgga gatgatcagg
     4981 ggagcttcat ccggcaggag aaggagtcgc tgccgttcca ttcggcctgt gatcatgccg
     5041 tcgatctcgt tgggggcaag gccttcgttc tcttcgacga acagtgcgcg catatagcgc
     5101 tcggtttgca gcaggcctga gattcggccg gtctggagtt gtcggatcac aacggccttc
     5161 gcctccgact tcgcgaactc ctggaaccag tccgggtggt agtcgtgcag gtacggcgcg
     5221 atcagctcgt agctccgcac cagctgtccg cctgtcccga gcgcccggtc gaacatctcc
     5281 gcgtccttga gtgtcggcgg tgccttgctc aactcgaact gtgacacgcg ggtctgatgg
     5341 atgttcacca gcccggcgac ctcgtcctgc cgcaggccgg ccgcctgccg ccagtgcgcc
     5401 agctcgtcgc cccaggtccg cggccgatcg cccggatcca ccttcctgcg agccataccg
     5461 gctcaccccc cgctgtaaga gcgcctgaag tggcttgtgg aaacccttgg tgatcccacg
     5521 gtcacagacc gacacttcct ccgcaaggga tttgcgaaaa cgcgacgacc cttgcggtcc
     5581 tcctgcattc cctccgcatc ggatcgccct cgaacagtgg attggacatg acgaacctca
     5641 tcatcgagcg gaacttcccg ccctgcctct gcgcgcactg caacgacgcc gtccccgagg
     5701 cccgtctcaa cggtgacgac ctcgcccccg ccgcgcccgc ggccgtcccg ggcgccgttc
     5761 cgcccgtcct gccgtatctc cccgtccgcc ggggcgaggc cgtcttcgac gtccgcagcg
     5821 gccgctgggg cgccttcatg gccgtccacc agggcgtggt gttcctccgc cccttcggcg
     5881 gcggcgtcga gtgggacgcc gacccccggt ggctctcgca gcacaagccg ccgaagtcct
     5941 ccgtcgtctc ctgagccggc caactcccca tccgaggaac cactatgagc atcctgggca
     6001 ggatgacggc tgacgaccgc cgtcgcgccg ccgacgcctt cgacgacttc caggccaccc
     6061 tcgccgccgc cggcctcacc ctcccctcgg cgggcgtgga ctggcggtcg gcgcagacca
     6121 ccggggtcgt gctgatcgac ctgggcgccg tccgggcgga cgtcgtcgag cggctcaccg
     6181 acctcgtccg caggggactt cgccggtgag ccccgcgtga cggctgctat ccgcggccct
     6241 cttcgggctt caggtggagg acctcgcggg cctggtccgc ggcgcgggcg atgctctcgc
     6301 tgacgaagtc gaggaagcgg gcgacgttct ccaggcggtt ggcggccggg gtgtcggggc
     6361 cgaggacctt gacgccctgc cgcgcggtct cggcgacgag ggtggtgccg cggacgctgg
     6421 ccatcatcga ctggtaccag acgtcgtcgt cgacgacgta gcgctcgcgc cggcgttcgt
     6481 cgcgttcccg gcgcacgagg ccctgttcct caaggaacgc gaccgccttg gagatggacg
     6541 ccgggctgac ctggaggcgc tgggccagtt cggacgcggt gaggctgccc gcgtcgttgg
     6601 tgcagagggc ggccagcacc cgggccatca tcttgggcgt gcccgacgcc atgaagacgg
     6661 tggtgaacgt ctcctcgaac tcgcgcaccg cctcggggtc gcgcccgtgg gcctgttcgg
     6721 gtgcctgcgg ctgccggggt gcggtctgcc tgcgctggtg ggcgcggcgt tcggtggcgc
     6781 ggtgggccag gtcggcgcgg tagccggtgg ggccgccgtt gcgcatcacc tcgcgcgtga
     6841 tggtcgaggt ggggcggtcg agacgcctgg cgatctccgc gtaggcgagc ccgtcgccca
     6901 cccccagcgc gatctgctgg cgttcctgct gggtgagcct gcctcccggc atcgcgatct
     6961 cccttcgagc ttccctgatg ggcgccagca tagcgttcac agtgggtcca atgcaacgag
     7021 tgggacaact ggcgttgcgt tagattcagg actgttgcaa cgaaatttct actccgacct
     7081 gcgctgatgc tgattccgtg caacgaagtg attgcgtgat ccttgaacgc aacgtagctt
     7141 ttgcgatgtc ggaaacaaca agtgcaggag agcacgatgc agaagttcca gacccccgcc
     7201 ccgatcaccg ccgtcctcga catccccgcg ggacgcatcc aggtcatcgc cgccgagcgg
     7261 cccgacgcca tcgtcgagat cctgcctgcc aacccctcca agaagcgcga tgtccaggcc
     7321 gccgagcaga ccaccgtcgc ctacgccgac ggcgtcctgc ggatcctcac cccgccggcc
     7381 aagaaccagc tcctcggccc ctccggatcg ctggaggtca ccgtcaagct gcccgccggc
     7441 tcccgcatcg aggcgaagac ggcctgcacc gagttccgcg ccgtcggacg gctcggtgac
     7501 atcggcttcg aaggcgcgta ccgccagatc aagatcgacc aggccgcggg actgcgcctc
     7561 accgcggtcg acggcgacgt cgaggtcggc cggctgggcg gtcccgccga gatcaccacc
     7621 gcaaggggca gcatccggat cgcggaggcc gcgagcggga cggtcgtgct cagcacccag
     7681 tccggcgaca tctcggtcgg agccgccgcc ggcgtctccg cctccctgga cgcgggcacc
     7741 ggctacggcc gcatcaccaa cgccctcaag aacgacggca cccccggcct ggacatccgc
     7801 gccaccacgt cctacggcga catcgacgcc cgcagcctct gaacaccctg aaggagcacc
     7861 gatcatgacc aacctggcca tcgcggcgaa cgggctgcgc aagtcctacg gcgacaagac
     7921 cgtgctcgac ggcgtcgacc tcgccgtccc cgaagggacg atcttctccc tgctcggccc
     7981 gaacggcgcc ggcaagacca ccgccgtgaa gatcctctcc accctcatct cggccggccc
     8041 cggctccggc gacatccaca tcggcggcca caacgtggcc accaaccccc aggcggtccg
     8101 cgccgcgatc ggcgtcaccg gccagttctc cgccgtcgac ggtctgatca ccggcgagga
     8161 gaacatgctc ctcatggcgg acctgcacca cctctcccgc agcgagggcc gccgcaccgc
     8221 cgccgccctg ctggagcgct tcgacctcgt cgaggccgcg aagaagcccg cctccaccta
     8281 ctccggtggc atgaagcgcc ggctggacat cgccatgacg ctggtcggcg gcccgcggat
     8341 catcttcctc gacgagccga ccaccggcct cgacccgcgc agccgccaca acatgtggca
     8401 gatcatccgc gagctcgtct ccgacggcgt caccgtcttc ctcaccaccc agtacctgga
     8461 ggaggccgac gaactcgccg accgcatcgc ggtgctgaac gacggcagga tcgccgccga
     8521 gggcaccgcc gaggaactga agcggctcgt ccccggcgga cacgtccggc tccgcttcac
     8581 cgacccggcc gcctaccagc gcgccgccct cgccctggac ggggccaccc gcaacgacga
     8641 gacgctgtcg ctccaggccg ccagcgacgg cagccagcgc gagctgcgct ccatcctcga
     8701 ccggctggac tccgccggcg tcgaggcgga cgaactgacc gtgcacaccc ccgacctcga
     8761 cgacgtgttc ttcgccctca ccggcggcgc ccgcatcccc agccagacca aggagaccgt
     8821 ccgatgagct ccctctccct cgccctgcgc gactcgtcca ccatgctgcg ccgcaacctc
     8881 ctgcacgccc ggcgctaccc gtccctcacc ctgaacctgc tgctcacccc ggtgatgctg
     8941 ctgctgctct tcgtctacat cttcggcgac acgatgagcg cgggcatcgg cggcggcgcc
     9001 ccggaccgcg ccgcctacat cgcctacgtc gtcccgggcc tgctgctgat gaccgtcggc
     9061 agcaccgtga tcgggacggc ggtgtccgtc tccaacgaca tgagcgaggg catcatcgcc
     9121 cgcttccgca cgatggcgat ccaccgcccc tcggtgctgg tcgggcacgt cgtcggcagc
     9181 gtgctgcagt cggtcatgag cgtggtcctc gtgggcgccg tcggcgtggc catcggcttc
     9241 cggtccacgg acgcgaccgt cctggagtgg ctggcggcgt tcgggctgct cgtgctcttc
     9301 gccacggcgc tcacctggat cgcggtcggc atgggcctgg tcagcccgaa cgccgaggcc
     9361 gccagcaaca acgcgatgcc gctgatcctg ctgccgctcc tgtccagcgc cttcaccccg
     9421 gtccactcca tgcccggctg gttccagccg atcgccgagt accagccctt cacgcccgcc
     9481 atcgagaccc tccggggcct gctgctcggc agcgagatcg gcaacaacgg ctggctcgcc
     9541 gtcgcctggt gcgtgggcct cgcggtcctc ggctacttct ggtcgacctc gaccttcaac
     9601 cgcgacccga agtagccggc gtgacggcac gggccgcatc ccgcagatcg tccagcctcc
     9661 cgcagctcgt cccgcccggg gcggcgtact ccgacaccac gtcggtgcac gccgccccgt
     9721 cggcgttccc ggccgtccgc cgctccggca ggacggccgg aagtgccgtg cgggagccgg
     9781 tgggacgagg gggaccggcc gtacaggtga tccagtacgg ccggtttcct gcggcaggtg
     9841 ttcgagtcaa tgggcctatt tcatatgact gttcctgttc tccggtgtgg ccttccggca
     9901 gggggtaatg ctgagccgac cgggtggcgg gtggtgcagg accgaggccc gcctcgttgt
     9961 gccggtcggc ctcctcgaca cgtccagaaa ggctcgcccg gtgactcagc cgttcgaact
    10021 gccctccttc tacgtgccgc acccggcgcg cctcaacccc catctggaag aggcccgcac
    10081 ccactccacc gcgtgggcgc gggagatggg gatgctggag ggttcgggga tctgggacca
    10141 ggccgacctg gaggcgcacg actacggcct gctctgcgcc tacacgcacc cggacgcctc
    10201 cgccgaggtg ctgtcgctgg tcaccgactg gtacgtgtgg gtgttcttct tcgacgacca
    10261 cttcctggag gtcttcaagc gcaccaacga ccgcgagggc ggcaaggcct acctggaccg
    10321 gctgccgctg ttcatgccgg ccgacccgtc cacgccgatg cccgagccca ccaacccggt
    10381 cgaggcgggc ctggccgacc tctggcggcg caccgtgccg gcgatgggcg aggactggcg
    10441 gatccggttc gccgagagca cccggaacct gctcaacgag tcgctctggg agctcgccaa
    10501 catcaacgcg ggccggatct ccaacccggt cgagtacatc gagatgcgcc gcaaggtcgg
    10561 cggcgcgccc tggtccgccg ggctgatcga gtacgcggcc aacgccgagg tgccgcagga
    10621 ggtttcggga tcacggccgc tgcgggtgct gatggacgcc ttctcggacg gggtccacct
    10681 gcgcaacgac atcttctcct accagcgcga ggtcgaggac gagggcgagc tgagcaacgg
    10741 catcctcgtc ctggagacct tcctgggctg ctcgacgcag gaggccgcgg aggccgtcaa
    10801 cgacctgctc acctcgcggc tccagcagtt cgagaacacc gtgttcaccg aactcccgtc
    10861 gctgttcgcc gaaaccgggc tggacccggt gggctgcgcc aaggtgctgg cgtacgtcaa
    10921 gggcctccag gactggcagt ccggcggcca cgagtggcac atgcggtcca gccggtacat
    10981 gaacgacggc ggcgcggcgg ccgggtcggc cgggggcaac tggtgggacc agtacgcgat
    11041 cggcgggatc ggcacgtccg cgctggacgt gctgaggacc ggcccgggtc gtgcgctgcc
    11101 cggcgggatg ggcgagttgg gctcgctgag cggcgcgccg gggatcaacg cgccggggat
    11161 caacacgctg gagggcacgc ccgggtcgcc gggcggcgtc gacccggcgg tgcggcgcgc
    11221 ccgttcgcac gcccacgtgc cgttccagca cgtgggcccg tcccgactgc ccgagttcaa
    11281 gctgccgttc agtgtcgatc tgtgcaagca cctggacacc tcgcggcgcc acaccgtcga
    11341 gtgggccggc cggatgggca tgctggaggc acagcccggc gtgcccggat cggacgtctg
    11401 gagtgccggg acggccttcg actacgacct cccgctctgc gcggccggca tccacccgga
    11461 cgccaccgcc gagcaactcg acctcacctc cgactggttg acctggggca cgtacggcga
    11521 cgactactac ccggcggtgt tcgggcggac ccgcgacctg gcgggcgcca ggctgctgac
    11581 cgcgcggttc tcggagttca tgcccctcga cgacggcccg gtgcccgagc cggccaacgc
    11641 cctggagcgc ggcctcgccg acctctggga gcggaccgcc ggaccgatgg ccgccgatgc
    11701 ccggcagaag ttccgggtgg ccgtcgagtc catggtgcag agctgggtct gggagctcga
    11761 caaccaggcg cagaaccgga tccccgaccc cgtcgactac atcgagatgc ggcgcaggac
    11821 cttcggttcc gacctcacga tgagcctctg ccggctggcc cacggggagt ccgtgccgtc
    11881 cggggtctac gagagcgggc cgatgcgctc actggagaac gcggccgcgg actacgcgtg
    11941 catgatgaac gacctgttct cgtaccagaa ggaggtggag tacgagggcg aggtgcacaa
    12001 cgcggtgctg gtggtgcaga acttcttcaa ctgcgactac ccggccgccg tccgcatcgt
    12061 cgacgacctg atgcactcgc gggtggagca gttccagcac gtggcgcgga acgagttccc
    12121 ggtgctctac gacgacttcg acctgggtcc ggagggccgg gcgatgctcg acgggtacgt
    12181 caaggagttg gagaactggc tcgcgggcat cctgatctgg caccggggct gcaagcggta
    12241 cacggaggac gacctgaagc ggcacttcgg gcgggaggag ctcccggagg cgccggccgc
    12301 ggtggacgac gcgctgctcg ggccgaaggg gctggggacg tcggcggcgc ggctcgtggt
    12361 ggcggcggcg ccggcgggtg cggccgccgg tgcggcggag ggggcgccgc gcccggggct
    12421 ggtgccgtcc gggccggccg gcttcgggac ggcgggggcg cgggcaccgt tcgccgcggc
    12481 gctgcccgct ccggtgggcg tggcaggcgt ggccggttag cggcacgccg ccgttgccgg
    12541 gacggcccgc cgggtgggtg caccggcggg ccgccgccgt tcgggcggtg gacgggtacg
    12601 ggtggccggg gtggctcggg gcgcggccgg gcgggggact ggctactgtg gcgaatcggg
    12661 gcaaaacatc acagatgtcc cacttgtcac ttgtcacctg tcactggaag agggcagacc
    12721 catggccgtg ctacccgagg gcacaccctg ttgggccgac gcgatgttcg ccgatttgga
    12781 cggggcgaag gcgttctacg gcgacgtgct cggctggacc ttcggcgaga gctcgtcgga
    12841 gttcggcaac tacacgacgg cgtactccga cggcaaggcg gtcgccgcca tcgtgccgcc
    12901 gatgccggga gcggacgcgc caccgtccgc ctggtgcctg tacttcgcct cgccggacgc
    12961 cgccgccacc gccgagggca tccgcgccaa cggcggcgag gtactgatgg gcccgatgca
    13021 ggtcggcgac ttcggcacca tggcgatcgc caaggacccg ggcggcgtcg cgttcggcgt
    13081 ctggcaggcc ggcagccacg agggcttcga gaagcagggc gcacccggcg cgtacacctg
    13141 ggccgaggtg ctcacccgcg agcccggaaa ggcggacggg ttcttccccg cggtcttccc
    13201 gttcaccacc aagaagatgg agagcgggga gatggactac aagatcttcc acgtcgaggg
    13261 ccaacccgtt ctcggccgga tgaagatggg cccggaggac ctcccgcccg aggcgccgtc
    13321 ctacgtcagc gtgtacttcg ccgtgaacga ctgcgacgtg gccatcgcca ggatcaccga
    13381 gcgcggcgga aagctgtacg ccgggccgat ggacaccccg ttcggccggt tcgcggcggt
    13441 cggcgacccg cagggcgcgg ccttcggcat catcgacctc ggcaggacgt cgggggagat
    13501 gcccgtgatg gcggacgcgt gatgggcgga cgcgtgacgg acggggtgcc ccggtgagca
    13561 gcgagcgcgc cgacctgctg cagacgctgg acaagcaccg cggcttcctg cgccacaccg
    13621 tccgcgacct caccgacgaa caggccgccc ggcgcaccac cgtgagtgag ctgtgcctgg
    13681 gcggcctgat caagcacgtc atgggcgtcg aaacgcggtg gatgcggttc gcggtcggcg
    13741 gcgcggacgc gatgaacagc gagccggtcg actgggaggg ccagttccgg atggcggacg
    13801 gcgagacgct ggagtcgctg ctggccgcgt acgagcgggt ggcgcacgag accgacgagc
    13861 tggtctcgac cctgcccgac ctggaccgca cccacccgct gccgcaggcg ccgtggttcg
    13921 aaccgggcgc cggctggtcg gtgcggcggg tgctgctgca cgtcatcgcg gagaccgcgc
    13981 agcacgccgg gcacgcggac atcatccggg agtcgctgga cggggcgaag acgatgggat
    14041 gacgaagacg gtggggatga ggggcgcgct caggcgagcc ggaggccgag cagctcgctc
    14101 agggcccggt cgccgtcggc cgtcacccgc agggcccggc cggagccgat ccgctccacc
    14161 caggcccggt ccagcgccgt ccggcagagg gcggcgccca gcaccccgcc cagatgggtg
    14221 cggcgctccg tccagtccag gcagccgcgg accagcggcc ggccgccgcc gcgccccgcc
    14281 cgggccggga gttcgatacc ggcggcggcc agccactccc gcccgctccc ggtgacggcg
    14341 agcccggcgt cgtccgccac caggccgcgg gccagcacgg catcggtgac cgccacgccg
    14401 aggcggccgg ccaggtggtc gtagcaggtg cgggcgcggg cctcggcgct cagccgggtg
    14461 gactcgcgca gattgcgggg ggccttggcg ggcgccttcg cgggtgccga ctccgcgaag
    14521 gaggcgaggt cctcgatcag cgccgccgcc tccgggccgg ccagccggac gtaccggtgc
    14581 cgcccctgcc gctcctcggc cagcaggccc ccggcgatca gccgggacag gtgctcgctg
    14641 gccgtggacg gcgcgacgcc ggcgtggcgg gccagctcgc cgccggtcca ggcccggccg
    14701 tccagcaggg cggtgcagaa cgcggcgcgg gtcgggtcgg cgagcagtgc ggcgagctgg
    14761 gcgagtggca tgggtccatg gtgccccggg cacggttcgg ccggggccga aacgttccgc
    14821 gcctagcgtg acgggcatga gcaccccgag catcttgagc atctccggga cgtccgaacg
    14881 gtcccaggag cgttccctgg agcggtcctt cgagcggtac gacgatgtcg tggacgccct
    14941 cgcccacccc gacctggtgc cgctgcccgc cgcctccggg ccggccgggg gcgtggcgtg
    15001 gctgcgggcg gccgtcgccc ggttcagcgc gggggaggag cacgcggccc ggcgcgccat
    15061 ggtcgaggcg gacctcgccc ggctcgaccc ggccgccctg cgggtggccg ccgcggccgg
    15121 gttcgagccg gacgcgcggc tgcgggccgt ccgcgccctc gcgcagggcc tcgggctggc
    15181 ggagccggac gccgtcgcgc aggcggtctc cgtggtggcg cgggcgtact tcgcggaggc
    15241 gccggacgac gccgaggcgg acgcggcggt ggcctggctg ctgccgcgga tggccgcggg
    15301 cggcggggcg gaggacgggg cgagcgtcgg ggtgggcgtc gggggcccgg ttccggagga
    15361 gctcgccgcc aaccggatcg gcctgctcgt ccaggcctgc gacgccaccg ccaccctggt
    15421 cgggaacgcc cggcgggccg gctgccgcag cgcggcggga gacgcgccgg gcggcgaggg
    15481 cctgctcgac cggggcctgc tcgaccggac gctgcgccac gacccgtcgg tgccggtgat
    15541 gcggcggctg gccgtgcgcg acgcggtggt gggcggggtc cgactgccgg ccggcacacg
    15601 ggtcgtcctg gacgtcgccg ccgcccagca gggcgccccc ggccggccgc cgctcacctt
    15661 cggggggccg ccgcgggtct gccccggccg cacccacgcg ctcgccctcg ccgccggcat
    15721 cctgcacggc gcgtccgacc cggcgggccc gacggccgcc gacacccccg tgaccgacgg
    15781 acgcgacccg ggggcggtgg tgtccgcgac ggtggagcac gtgctggccc tcgccgcgac
    15841 gtggacggag tgggacgggc gcccggtggc cgccgacggc cggacgtaca ccccgcacaa
    15901 ggcggtccgc cgggttgccg accatctcct cgaccacctc gccgagttgg aggcccggct
    15961 ggccggcgag gccaccgaac ccgaccactg gcacgcctcc gccgccacca ccccggccga
    16021 cctcgcgccg ttcaccccgg ccgacctgga cgaggcccgc agccgcctca cccggctcgc
    16081 ccggatctgg gcccggcgcc tcgccgccct caccccggag cagctcgacc actcacccgg
    16141 tacgggctgg acgttccggc aactcgcctt ccacgtcgcc gagtcggcgt actacgcgga
    16201 cgcggtgggc gacctgcgcg ccggtgcgga aggggccgcg tcgtgactcc gttcgccgca
    16261 ctccaccacc ggcccggcga gccgctgctg ctccccaacg cctgggacca cgcctccgcc
    16321 gccgccctcg ccgggcaggg cttcgccgcg atcggcacca ccagtctcgg cgtggccgcg
    16381 gccgccggtc tgcccgacgg cgtggccgcc acccgccggg agaccctccg gctcgcccgc
    16441 cggctcgggc gggggcggtt cctgctctcg gtcgacgtcg agtccgggtt ctccgacgat
    16501 ccgtccgaag tggccgatct ggcggtcgag ttggctggcc tcggtgcggt cggcatcaat
    16561 ctggaggacg gccgggggga cggcacgctc gcgcccgtcg ccgtgcacgc cgcgaagatc
    16621 gcggcggtga aggcggccgc ccccgacctc ttcgtcaacg cccggacgga cacccactgg
    16681 ctggggaccg ccgaccccgg gccggagacc gaccggcgcc tcgccgccta ccaacaggcg
    16741 ggcgcggacg gcgtgttcgt ccccgggctg gccgatccgg cggccatcga ggccctggcc
    16801 gggcggctcg ccgtcccgct caacatcctg cacagcccgg cgggcccgcc gctggggcgg
    16861 ctcgcggacc tcggtgtcgc ccgggtcagc ctcggctcgc tgctctaccg ggcggcgctg
    16921 gcggccgccg tgcagacggc ggtcgccgtc cgggagggcg gggccgggcc gatggcgggt
    16981 gcggtgcccg cgtacgggga ggtcgcgggg ctgcaccggg acgggggtca ggggtagtcc
    17041 tcggcgggat ggcgtcgaaa cgggcgcagg gggccgcgcc tgacggggcg gcagccgacg
    17101 gaagagccga tagctaaacc atcgacatat cccaatggct gacctatgct cccgatcatg
    17161 ggaaaccgtc aactacagga gccgaccagg ctcgtgctca ccgcgctggc cgacgccccg
    17221 cggcacggct acgcgatcgt ccaggaggtc ctggccatct ccggcggccg gaccaagctc
    17281 ctcaccggca ccctctacac ggcgctggac cgcctcctcc agcagggcct gatccggatc
    17341 gaccaggagg aggtcgtggg cggacggctg cgccgcacct tcgccctcac cgaggacggc
    17401 cgcggcgtac tggccgagga gacggagcgc ctgcgcgccg gggtcgtcga ggcggagcgc
    17461 cgcctcgccc tcggccgccg gcccggcctc caggcgggtt tcgtgcggct cgcgccggcc
    17521 gggggtgcgg catgagcgcc tcgtccccgc agttcggcct gcccacccgc ctcccgctgc
    17581 tcggcctcta ccccgccaag taccgggctg cgaacggggc ggagatcgcc gccgtcctct
    17641 ccgagagcct tgagggcgcc gaccgccgca ccgtgctgcg cgagtgggcc accgtcgccg
    17701 cgcacgccgt ccggctgcgc acccggctca gctccagcga cccggcgggc cgcttccttg
    17761 ccggcgccgc gccgtacctg ctggccggcg gggcgggcct ggccgtggtc cacctgctgc
    17821 tcgggctctt cctgcccgac cagttcggcg acgagggcca ccccgccctg cgggtcgccg
    17881 tgggcgcggt gcagaccgtc ccgtggatcc tcgccctgct ctgcgcggcc ggcggccgct
    17941 ggggggcggc ccggctcctg gtcctggcgg gcaccctgat gcggacggcg gccgccgcgg
    18001 ccttcttcgc ccacgagagc ctggcgctgt tccagtacct ccccctggcc ggcttctggc
    18061 tcctcctcag cgtcctgctc ctcgccccgc cggacggcgt cgaccactcc cggcgtgccc
    18121 gcaccgagat ggtggccacc gcgctcgccc tcgccctgcc gatgggtgcg ctcgccatga
    18181 tctggccctg gccggacgag ggcctggccg ccgaccacgt cttctccgac gccaaccgca
    18241 ccctgctgga cgtctccacc gcctggccgg ccgtcgtgat gagcatcgcg ctgctgctca
    18301 acctcgcccg ccggggcgtc gaccgcgtcc gcgccgccgg ggtcgcgctg gccgtcctgc
    18361 cctggacggc catgctggcc ccgccgtact actggcggcc gccgttcgac gggcacgacc
    18421 tgctgcgcaa cctgctcgtc gtgctcgcgc tgctggcctt caccgccacc gtggcggcca
    18481 cccgccaccg ggtccgcccc tcggtggagc cggtcgaacc ggcctgagtc cggcagcgcg
    18541 ccccccggcc cggagcgcag gcccgggccg gccggtgcgc ccgggtcgtc ttgccccggg
    18601 ccgcccgcgc cgcccgcgcc gccgcgaccc cggcgtcagg cggccgagcg cgggtcgacc
    18661 ggggtgaaca cgccgagccg gtcctcgacg gcctgggccg cgtcgaggca gaggtcctcg
    18721 cggaacgggc gcccgacgag ttggacgccg accggcagcc cgtcggtcac cccggtcggg
    18781 acggccacgc cggggacgcc gacgaagctg gtcaccgagc agaggcgcat cgccgaggcg
    18841 acccggtccc ggccggcccg gtcgcgcgac tccaggccgg gcccgacggg cggctcggtg
    18901 aacaccggtg cgagcagcag cgggtactcg tccaggaatt cggcccagga gcggcggatg
    18961 ttcagccagg tccccatcag cctcacgagc tcgtcggagg tggccggccg cacccgctcc
    19021 atcatcatcc cgatgaagcg gtccccgccc tcgccgagca gcccgcggac ggccggccag
    19081 ctcggggcga actcggtgac ggtgatccgg tcgtacgcct ccagcgcctc gtccagccgc
    19141 ggcacgtccg gcacctcgcg cacgtcgtag cccgcgtcgc gcagcgcctc ggcggcggtc
    19201 ccgacggcgg cgcggaccgc cgggtggacg ccgtggccgc cggggtcggc gaccaccgcg
    19261 accttcaccg gcccggggag ccgtgcgccg cggacgggca ccgggacggc ccacgggtca
    19321 cgcgggtcgc tgcccgccag cacctcgtag gcgagccgca gatcgtccac gctccgggcc
    19381 aacgggccgt cggtgaccag gaactgggtg gccggcccgg ggtcgtccgg gccgaggaca
    19441 cggcgatcgg ccgggaaccg cccggtggag ggcttcagcg ccgtcacgcc gcagaactgg
    19501 gccgggatgc ggaccgatcc gccggagtcg ttgcccagcc cgagcgcggc catgccggtg
    19561 gcgacggcca ccgcgtcgcc cccgctcgtc ccgcccgggg tgcggccggc gtcccacggg
    19621 ttggcggtgt cgccgaacag ctcgctgcgg gtgtgcatcc cggacaggat cagggtgggc
    19681 atgttgctgt gcccgatcgg gaccgccccg gccgcgcgga gccgggccac ggggagcgcg
    19741 tcggccggcg ccaccaggtc gcggaagcgc ttgacgccga aggtggtcgg cacgccctcg
    19801 acgggggtgc tctccttcac cgtgaacggt acgcccgcga gcggccccag ctgtccgccc
    19861 gccgcgcggt gccggtccgt cgccgccgcg gcctcgcggg cgcggtcggc gaggagctgg
    19921 gtgaccgcgt tcacctgcgg gttgaccacg gcgatgcggg ccaggtggct gtcgaccact
    19981 tcgacggcgg agacctcgcc gctgcgcacc gccgccgcct gctcggcggc cgtcatcgtc
    20041 cagatggtgt cctgcatcgc ccctgccgtc ctctcgtcgt cctcttgccg tacgtcgggc
    20101 acgtgttgcc gcactcgggc acgtgttgcc tacgcgggca cgtaccgatg cgctcgtatc
    20161 ggaacgcgct cactgtagcc tgtgaaccga tacgagcgca tcgaataagg aggcggccga
    20221 tgccccggca ggtggaccac gaggagcggc gccgcgtcat cgccgaggcg gtctgcgccc
    20281 tcgccgacga gcgcgggctg gagggcgtca ccgtgcgcga cgtcgccgac cgtgcgcaga
    20341 tctcgatggg ggccgtccag cgctgcttcc gcaccaagga ggagatgctc gtcttcgcgc
    20401 tcgcccacgt cggcgagcgc atcggtgaac gcgtccgggc ccgtctggtc cgcaccccgg
    20461 cccagtccgc cgcgaccgcc ctcggccacg cggccgccga ggtctccctg ctcggcgagg
    20521 agcaccgcgc cgaggcccgg gtctggctcg ccttcgtcgc ccaggccgtc gtcagcgcgc
    20581 cgctcgccga gaccctgcgg gccggctacg caccgctgga ggacgcgttc gcccgcctga
    20641 tcgaggaagg cgcggtccgg ggcgccggcg aacccgccgg ggaggacgcg cccctggacg
    20701 cacggcgaga ggcccgtacg gtcctcgccc tcgccgacgg cctcaccgtg cacgtcctcg
    20761 ccggccacct cacgccgcag gaggccggcg acgtcctcca cgcccatctg gcccgtctct
    20821 gggcggggcg gcagcccccg ccggcgtgac cgtccgaggc gctcgacggg gaagacgatc
    20881 ggacatcttt cgaagactga aggatattca gcggctcgtc cggccttcct agagttgagg
    20941 acatcagaag ccgcccggca gccgggcgga cgagccggaa ggaagaaccc ccatgcgtgc
    21001 agtcatccag aagtccttcg gcggccccga ggtccttgag ctcgtcgagg ccgagcgtcc
    21061 cgcccccctc ggtggcgagg tcctcgtccg cgtgcacgcc agcggggtca acccggttga
    21121 cgtggcagtc cgttcgggcg cctacccgtt gctcggcgag ccgccctacg gggtcggctg
    21181 ggacatctcc ggcgtggtcg aggaggccgg cccgggggcc aggttcaagg tcggcgacga
    21241 ggtgttcggc atgccgttct tcccgcgggc cgccactggc tacgccgact acgtcgccgt
    21301 gccgtcccgg caggtggccc gcaagcccgc gacgctcgac cacgtgcagg ccgccgccct
    21361 tccgctgtcc gccctcaccg cctggcaggg cctggtcgat gcggcgcaac tgtccgaggg
    21421 gcagcgggtg ctggtgcacc gcgcggccgg cggcgtcggc cactacgcgg tccagatcgc
    21481 gaaggcccgc ggtgcccacg tgatcgccct cgccagcgag tccaagcacg agttcgtgcg
    21541 cggcctcggc gccgacgagg tcatcgacta ccggatcacc gactacaccg aggtggtgcg
    21601 cgacgtcgac gtcgtcttcg actcgtcctc cgagggcacc cgtgcactgt cggtgctgcg
    21661 gcccggcggc accctggtca gcatcatgga gcactggaac caggagctgg cggccaagat
    21721 cgaggcggcc gggcggcggt tcgcgggcgt ctcggtcgag cccgactacg cgtcgctgga
    21781 ggcgatcgcc gccctcgtcg acgccggccg gatccgcccg cacgtcgccg agaccttccc
    21841 gctcgccgac gcgggcaagg cccacgagct ggtcggctcc ggccgggtcc agggcaaggt
    21901 cgtcctcacc gttgcctgag cgggacggtg acggacgggt gagggggagg ggggaggtgc
    21961 cggaggggcc cgacgggggt gggcccctcc ggcaccggac caggcgggcg gaagggcgaa
    22021 gtccggccct caggtccgtc ttcaaactcc caccctccgg gcggacgacg ggagtttgaa
    22081 gacggacctt agggtgggga cggaacacgg cgaacggggg cggaccatgg acatcctgac
    22141 cgaggcactg ggctcgatgc ggaccgggaa ccccacgtcc gtccgcaccg agggccgcgc
    22201 cccctggggc ctgcgcctgc ccccggtcgc cggcgccggc ttccacgtgg tgctgcacgg
    22261 cacctgctgg ctgatcccgc tggagtgcgc cggcaacgac gagccgatcg ccctcagccc
    22321 cggcgacgtc gtcttcctgc gcgacggccg cggccacatc ctcgccgacc accccagcac
    22381 cccggccgca ccggaacggc ccgaccagta ccggccgagc acgccgatcg gcacggtcac
    22441 cctcggcggc gacggccccc ggaccagcct cctctgcggc aactaccacc tggaccaggg
    22501 ccgcccgcac ccgatgctcc
//
