LOCUS       NZ_CP026498            20948 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. CB01881 chromosome.
ACCESSION   NZ_CP026498
VERSION     NZ_CP026498.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB01881
  ORGANISM  Streptomyces sp. CB01881
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     A 3-hydroxy-3-methylglutaryl-CoA synthase gene based probe for the
            discovery of the acyltransferase-less polyketide synthases
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) Xiangya International Academy of
            Translational Medicine, Tongzipo, Changsha, Hunan 410000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002953255.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 02:39:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,978
            CDSs (total)                      :: 7,904
            Genes (coding)                    :: 7,565
            CDSs (with protein)               :: 7,565
            Genes (RNA)                       :: 74
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 124 of 339
            Pseudo Genes (incomplete)         :: 251 of 339
            Pseudo Genes (internal stop)      :: 10 of 339
            Pseudo Genes (multiple problems)  :: 45 of 339
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:44:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1618983
            Orig. end                         :: 1639931
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026498.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20948
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20948
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20948
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10948](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10948
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(1202..2113)
                     /locus_tag="C2142_RS07080"
                     /old_locus_tag="C2142_07035"
     CDS             complement(1202..2113)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134864.1"
                     /locus_tag="C2142_RS07080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07035"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_148641589.1"
                     /transl_table=11
                     /translation="MSTTTDRPTTAAARPAPPAGRPPKVRPRGQASPAARALSHGALIL
                     ASLIALFPVVWILYVSLGPDKTDYLHPGAILDKMTLSNYHTVLFDTDFFTWFGNAFLVS
                     GVTTVFGVLIAATTGYAVSRMRFPGHKPLMWSLLVTQMFPIAVLIVPMYTILSELDLLD
                     SYLGLILVYSTTTVPYCAWLLKGYFDTIPVEIDEAGRVDGLSPFGTFWRLVLPLARPGL
                     AVAAFYSFLTAWAEVAFASTFMLSSDKYTLAVGLQTFVSEHDAQWNLMAATAVLIAIPS
                     SVLFYLVQRHLVTGLTAGASKS"
     gene            complement(2153..3157)
                     /locus_tag="C2142_RS07085"
                     /old_locus_tag="C2142_07040"
     CDS             complement(2153..3157)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388383.1"
                     /locus_tag="C2142_RS07085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07040"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_148641590.1"
                     /transl_table=11
                     /translation="MSVAVQGATGQGSRERDPRPGLMERLKRSYAKHWYAYAMIAPVVI
                     VLGVLVLYPLAEGLWLTLTDANSLNAARKIGVNEIPASYKFVGFDNYADILWGPGSYDR
                     FWSHFVWTIAWTAICVCLHYTVGLGLALLLNQKLRGRAVYRMLLILPWAVPTFVTVFSW
                     RLMLADGGAVNGLLSALHLPEPGWLDDPLAQKAAAVLVNTWVGVPFMMISLLGGLQSIP
                     AELYEAAEMDGATPWQRFRHVTLPGLRTVSSTVVLLGVIWTFNQFAVIFLLFGGNGAPD
                     AQLLVTWAYRLGFGQQPRDYAQSAAYGVILLSILIVFTAFYRRWLARNEQANG"
     gene            complement(3262..4539)
                     /locus_tag="C2142_RS07090"
                     /old_locus_tag="C2142_07045"
     CDS             complement(3262..4539)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020137305.1"
                     /locus_tag="C2142_RS07090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07045"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_148641591.1"
                     /transl_table=11
                     /translation="MRRGIAASALVVALAVSMAACGSSGSSSDGKADGPVTLTYWDTSN
                     ATNEAPNYQALVKKFEEANPNVKVDFVNVPFDQAQNKLQTAMGAKGAPDVFRSEVGWTA
                     AFAKAGYLEPLDGTAAAADAGAFQPSLVQQAKYEGKLYGVPLVTDTLGLLYNKELFTKA
                     GITAAPKSWDELKTAAAAVKEKAGVDGFWLKAADGYYAMPFLFGEGTDTVDAAGKKITI
                     GSPEAVKGIETYKTMFTAPGTAKADVTSDAYAHMMDAFNSGKVAAIIQGPWEITNIYKG
                     TAFADKTNLGIAPVPAGSAGKAGAPTGGHNISVYAGSDKAHKAAAEKFAAYMTSAESQA
                     FIAQKNSTLPTRADAFTPEVKADPGIAGFQSVLTSARPRPELAEYSSLFASLGTNLGKV
                     VQGTGTQDGLNTVATDYAKLLPGFAK"
     misc_feature    complement(4684..4698)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.92"
                     /tool="antismash"
     misc_feature    4685..4698
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.28"
                     /tool="antismash"
     misc_feature    complement(4687..4700)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.47"
                     /tool="antismash"
     gene            4848..5423
                     /locus_tag="C2142_RS07095"
                     /old_locus_tag="C2142_07050"
     CDS             4848..5423
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016467379.1"
                     /locus_tag="C2142_RS07095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07050"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_148641592.1"
                     /transl_table=11
                     /translation="MRIRAATREDLPLLRELERAAGAPFTAIGMPEIAEDEPPTVEELA
                     HYLDGGTALVALSDEGGGRAGGDADDGRAGGEEGERGTPVGYLLAEPVDGALHIEQVSV
                     HPGHARRGIGRALIEHLAATTDAPALTLTTFADVPWNAPYYARFGFRPLADAEITPGLR
                     EIRRREAGHGLDRWPRLCMRREIGAGLS"
     gene            complement(5416..6498)
                     /locus_tag="C2142_RS07100"
                     /old_locus_tag="C2142_07055"
     CDS             complement(5416..6498)
                     /EC_number="5.1.3.-"
                     /GO_function="GO:0016857 - racemase and epimerase activity,
                     acting on carbohydrates and derivatives [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134867.1"
                     /locus_tag="C2142_RS07100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07055"
                     /product="aldose epimerase family protein"
                     /protein_id="WP_148641593.1"
                     /transl_table=11
                     /translation="MATPPANGSQATSVRREPLEPAGAGAAIERWTLRAGPYEATVLTL
                     GATLHSLTAPDRTGHPAQVLLSSDRLAEILGPARHYGTVVGRYANRIDGSKVTIDGEEH
                     PLAPTGGGVTLHGGPDGFAHRMWESEPLPDGVRLHLHSPDGDQGFPGALDVTVDYTLSA
                     AGELVIGYRATTSRPTVLNLTNHAYFNLAGEGSGDVLGHLLTLDADEYTPADHRQIPYG
                     RTEPVAGTPFDFTSPRPIGKSVQDEHPQLTGPGGYDHNWVLRPRPADGTPARAALLEDP
                     ASGRTLEVLTTEPGVQVYTANKFQGAVTGASGVPYGPFAGIALETQHFPDSPHHPAFPS
                     TELRPGEEFRSTTVLRLGVS"
     gene            complement(6669..7676)
                     /locus_tag="C2142_RS41945"
     CDS             complement(6669..7676)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS41945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_346766364.1"
                     /transl_table=11
                     /translation="MGLARFRRGLLAEAEDFLRRALRLSERIGPKLPLAWDAVGVLVDT
                     LIARGRTNEAWDLAIGFGFSPPYHSTAMVLPDAASLYGKLLLAKGRNAGAAAALTEAGA
                     QLDARGWHNTVWAPWAGHLAVALAEDEPERARAYAERSVRDARRFGTASAIGTALRLHA
                     EIADGQQAVELLEEAVRHLGQSPAGYEHAVALVDLGAALRRVGRLEDAQEYLYQGIELA
                     QHCAADGLVDRARRELANYGLRPNRLGDVREMLSQPEWDVARLAVRGVPPQRIADELGV
                     HLSLVNRRLAAVYRKAGSGPDGLASALGLPPEQRDGTEDGREGAAGRDGGTAEA"
     gene            complement(7676..9703)
                     /locus_tag="C2142_RS41950"
     CDS             complement(7676..9703)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="C2142_RS41950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_346766365.1"
                     /transl_table=11
                     /translation="MTEQGHEFRAGAGADGREPETVPHRVRLRDRDAELRSAEAAVEKL
                     CRDFAAGGTEIGELLTFSGRPGIGKTSLLHEVRRIAKLREGTTVLFARGGERQSNEPYH
                     VLRQLLQPVLGGLDPAEFRQVMGTWEEVVGPAMGLKQPKAGARRLDPQGVRDGLDYVLT
                     QLAPRRAPLVMIVDDLHWSDLESLAWLASFALRASELPVLLVFAYRDDIADWQPEAQEH
                     QAAVTSLATRRHELGRLTLVSVTDMVRAELGDKAEDAFCYEFWNVVNGNPFEAVALLDQ
                     VRDQELDPVEENSQQLRELAVDATGTTLTGWLERLGASTLRFAWACAMLGTDIRPDLAA
                     RISTQSLEGSRESIKQLRKQRVLTQTPNGNLEFVHPLIGSSIYNTMKESTKTGMHGVAA
                     AEIENAGLGLLAASRHLVETFPGEGDDRTVRKLRKAAQEHLLIGAPEAAQRCLHRALAE
                     PPDDDIRAEVLYELGCSALLTDPMATVNQLKLALDPDEGPLRPSLRVDATFRLSEVLAH
                     SGQLGEAARVCQDEAEKTDDDSAGRLRLEAAAFMWHAYRKSEEDGPARSERLGALCRSL
                     TGREAADRAVLALRAWDLTLRGEPSAEVLRHADQVLDQGRLPKGLGWTDSTWGFELPAT
                     LGLSYTYSDRIAQAERLFGDASSSSRSRAGAVPTAASRTS"
     misc_feature    complement(9816..9828)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     gene            10001..10948
                     /locus_tag="C2142_RS07110"
                     /old_locus_tag="C2142_07070"
     CDS             10001..10948
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="C2142_RS07110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07070"
                     /product="terpene cyclase"
                     /protein_id="WP_148641595.1"
                     /sec_met_domain="T1TS (E-value: 5.5e-69, bitscore: 232.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDTSLQIPFPHRRSPHGPHAAELHRDWLTRHPLLPDPSHPSYA
                     HWDVVALAALGYPDAGPDELALAADLMGFYFLFDDQFDGPLGRRPAEVAPICERLISVL
                     HGAGPDPSSAVETAFADLWERSVRGMPARWQARAAYNWEWYLASHPAEAAGRISGRPPD
                     RDGYLALRRGTAAMETIFDMVECLGHFEVPAAVLHHPVLRQIRQLAADIPSLSNDVRSF
                     PLEAPRGDVNNLVMIVQRERRCSAEEACAVVMDEAQLMVERCRELYDRLPDVHRELGLS
                     RVERTVAQRYADGLVTWLAGYLNWESHTGRYLAA"
     gene            11248..12771
                     /locus_tag="C2142_RS07115"
                     /old_locus_tag="C2142_07075"
     CDS             11248..12771
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056340.1"
                     /locus_tag="C2142_RS07115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07075"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_148641596.1"
                     /sec_met_domain="Aldedh (E-value: 7.9e-157, bitscore:
                     521.3, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVYQPPGTPGSIVNYRPRYEHWIGGRWTPPVRGEYFENPSPVTG
                     EVFTEVARGTAEDIEAALDAAHAAAPAWGRTAPAERAQVLLRIADRMEANLEALAVAES
                     WENGKPVRETLAADLPLAVDHLRYFAGALRAQEGGLSQLDEDTVAYHFHEPLGVVGQII
                     PWNFPILMAVWKLAPALAGGNAVVLKPAEQTPASILVLVELIADLLPPGVLNVVNGFGL
                     EAGRPLASSSRIRKIAFTGETTTGRLISQYASGNLIPVSLELGGKSPNLFFADVAAEQD
                     AFYGKALEGFAMFALNQGEVCTCPSRALIQSTVYDRLLADGLERVRSMRQGNPLDTETQ
                     VGAQASDDQLKKILSYIEIGQAEGAKVLAGGERADLGGSLAGGYYVTPTVFEGVNGMRI
                     FQEEIFGPVLAVTRFEDFDDGIALANDTLYGLGAGVWSRDGNTAYRAGRAIQAGRVWTN
                     CYHAYPAHAAFGGYKNSGIGRETHKAVLEHYQQTKNLLVSYSPDALGLF"
     gene            complement(13005..13457)
                     /locus_tag="C2142_RS07120"
                     /old_locus_tag="C2142_07080"
     CDS             complement(13005..13457)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS07120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_07080"
                     /product="SHOCT domain-containing protein"
                     /protein_id="WP_206670927.1"
                     /transl_table=11
                     /translation="MFRPLRPIRPVRVMRPVGAPLVRGLVVGGAAYAAGRGAAGRRRGE
                     QDQNEAIAALQAQVAAPAGTAAPAAPAVAVVAAAQPGQAASAVPTASGLPTVPAVPAAS
                     AVPAVPTASAGAPDIADKLADLGRMAQQGLLTPEEFATAKARLLGG"
     gene            complement(13465..13893)
                     /locus_tag="C2142_RS07125"
                     /old_locus_tag="C2142_07085"
     CDS             complement(13465..13893)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018529397.1"
                     /locus_tag="C2142_RS07125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07085"
                     /product="DUF6325 family protein"
                     /protein_id="WP_148641597.1"
                     /transl_table=11
                     /translation="MGPAELLVLTFPQQTITIEAAEALAKLRTGGDVRVIDSLVVTRHP
                     EGEATYGELADFEHLRGVVPDGSAELPLIGPEDAQEAAELLAPGTVALLVLIEHVWAQE
                     TAEALREIGGRIASGVRIPPENIGEAVRAAEAHRAAGK"
     gene            14042..14365
                     /locus_tag="C2142_RS07130"
                     /old_locus_tag="C2142_07090"
     CDS             14042..14365
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013004167.1"
                     /locus_tag="C2142_RS07130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07090"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_148641598.1"
                     /transl_table=11
                     /translation="MTIAVAKLSDPAVRAFVAAVNSGDRTAFRDLLTPDATMSDDGSDR
                     DVDDWTEREIFSSHGHMDVQSESDGGHALIASYNNDTWGEMRTAWRFTVDHGKISRFET
                     GQA"
     gene            complement(14376..15602)
                     /locus_tag="C2142_RS07135"
                     /old_locus_tag="C2142_07095"
     CDS             complement(14376..15602)
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018559847.1"
                     /locus_tag="C2142_RS07135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07095"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_148641599.1"
                     /transl_table=11
                     /translation="MVEIWGGTAEGFEPVRDAFARNFREYGELGAAFALYVRGRKVVDL
                     WGGDARPEVGGRPAPAVPWTADTAQVLRSVTKGLTATTALLLADRGQLDLDAPVASYWP
                     EFKAAGKDRVPVSWLLSHQAGVPALDVPLRLEDVLTWERAAAAVAAQAPAWEPGTAHGY
                     HPYTFGWLVGEVVRRVSGRTVGQYFAEEIARPLGLDLWIGLPAGAAPRVGRLVDLPAPE
                     AARTGPSGLRLRPKQAVRDAYQDPASLTARAFASVRPGVDLNDPAVQAAEIPGAGGIGT
                     ARSLARFYAALVGAADRHGGGAGEVLPALFGPELLARAVGPAVSGPDRVLIVNSTFGLG
                     FFRHGPTSLMASPASFGHPGRGGSLGFADPDLGLGFGYVTNGMQPGVTGDVRSRNLIRA
                     VRGCLGLPA"
     gene            15712..16218
                     /locus_tag="C2142_RS07140"
                     /old_locus_tag="C2142_07100"
     CDS             15712..16218
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027918.1"
                     /locus_tag="C2142_RS07140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07100"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_148641600.1"
                     /transl_table=11
                     /translation="MTNPAEELLDVVDEHDRVIGTARRGEVYRDGLTHRCVFILVRDPA
                     GRIFVHRRTDTKLFAPGAHDMFVGGVVGAGESYASAAVREAEEELGVHGIEPEPLFKFL
                     YRGGGLSWWCDVYEARWDGPVSPQESEVAWHAWLTPAELDERLARDEFVPDGLEAYRRY
                     RELRG"
     gene            16656..17180
                     /locus_tag="C2142_RS07145"
                     /old_locus_tag="C2142_07105"
     CDS             16656..17180
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510897.1"
                     /locus_tag="C2142_RS07145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07105"
                     /product="ATP-binding protein"
                     /protein_id="WP_148641601.1"
                     /transl_table=11
                     /translation="MTTLLLMVGLPGAGKTTRARQLAAEYGALRLTPDDWMIPLFGEAE
                     ADGKRDVLEGRMLWLALEAVKLGTNVVVDYGCWSRDERSAIRWLVEAEEACFRMVYLPV
                     DDETQRARIAHRWATAPEETLPMSEADILHGRAHFEEPDAAELEGRGTAGPPPGWVGWR
                     EWAAARWPSFA"
     gene            17335..17862
                     /locus_tag="C2142_RS07150"
                     /old_locus_tag="C2142_07110"
     CDS             17335..17862
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS07150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_07110"
                     /product="hypothetical protein"
                     /protein_id="WP_148641602.1"
                     /transl_table=11
                     /translation="MTLSWDLLISTAGGVTATVVGVIAGGVIGRRGQHQQWLQGTQTAA
                     YEKFLQAFGAVEAELREAFLDERRPAVDWVPFVAAQHSVSLVADPATSAAAERVCEILE
                     DFTILFHGRQPTDIEELRPIHTALGEAHLSFVNAARCSLAPSQRRLDRSLGGPSPWRGV
                     ESFYTRPDRSLD"
     gene            complement(<18271..19144)
                     /locus_tag="C2142_RS07155"
                     /old_locus_tag="C2142_07115"
                     /pseudo=""
     CDS             complement(<18271..19144)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1237: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027876.1"
                     /locus_tag="C2142_RS07155"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="C2142_07115"
                     /product="IS110 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGGNNLIYCGIDWADRTHDVALVDDTGRLLAKRHITDDAAGCKLL
                     LDLLAEYGDTEDAPIPIAIETSRGLLVAVLRTGTRKVFAINPMAAARYRDRHAVSRKKS
                     DPGDALVLANILRTDMHAHRPLPDDSGLARAVAVLARAQQDAVWKQTADGQPAPLTATR
                     VLPGGVGRLRAVEKRPVPPRSPRDPQDSPHPGKGRAADPHAARRRPQEGRPQEGRPQAR
                     HRGRGRATARGLSRRLGPPAPAGRGRARPADARSPGPARGCLHRRRRPRPGRRGGVPAA
                     PGRRDHLQLS"
     misc_feature    complement(19113..19129)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.36"
                     /tool="antismash"
     gene            19792..20508
                     /locus_tag="C2142_RS07160"
                     /old_locus_tag="C2142_07120"
     CDS             19792..20508
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018486759.1"
                     /locus_tag="C2142_RS07160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_07120"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_241003132.1"
                     /transl_table=11
                     /translation="MSVDERREQLIAVALELFSRRPPEEVSIDDIAAAAGASRPLVYHY
                     FPGKQALYEESLRRAGRELAGRFEEPHEGPLSDRLHRVMGRYLDFVQSHGPGFAALLRG
                     GSVAASAGTSAVIDDVRQAAADQILAHLALPSPSPGVRLTVRAWIANAEITSLEWLAER
                     SVPLEELQLHLVQEFVASLTLTAAREPALAAEFAGFFAGERPDGPAGRLVRDLAGLFAV
                     PGIADAVAALAAEPSD"
ORIGIN
        1 gcatcagcag ggtggcggcg cgggcgcggc gcaggccgag cgcgcggtcg ccgggggtgc
       61 ggatctgggt gccgaggccg ggctcgttgg cgaaccgggt ggcgtgccgg gtgacgtcgt
      121 ggttggacag cacccaggtg gtgggggcgt cgacggggcg catcgagtcg agcgagaggt
      181 cgatcacccc gcgcagctcg gcggcgtccc aggaggtgcc caggtactgg aagttgaagg
      241 cctggtgcag ctcgtcgggg cgcacgtagt tggcggtgcg ctggacggtg ggggtccacg
      301 cctcggcgac gccgatccgc tggcccgggt actcgtccag gatccgccgc cagctgcggt
      361 agatctcgtg cacgccgtcc tggtcgaaga acggcatgac gtcgttgccg agcagcttga
      421 gctggtcgcc gccgccgagg tcgggcaggc cgggggcctt caccaggccg tgggcgacgt
      481 cgatccggaa gccgtcgacg cccatgtcga gccagaaccg caggatcgag cggaactcgt
      541 cggcgacggc cgggttctcc cagttgaagt cgggctgctc cggggcgaac aggtgcaggt
      601 accagtcgcc cagggtcccg tccgggttcg ccgtgcgggt ccaggccggg ccgccgaaga
      661 tggactccca gtcgttgggc ggcagttcgc cgttctcacc cttgccgggc cggaagtggt
      721 agcggtcgcg cagaggggac gcagggccct cgcgcagggc acgctggaac cactcgtgct
      781 ggtcggagga gtggttgggg acgaggtcca cgatgatccg caggcccagc gcgtgggcgt
      841 cgcggatcag cccgtcggcg tccagcaggg tgccgaacat cgggtccacc gcgcggtagt
      901 ccgccacgtc gtagccggcg tcggcctgcg gcgaggcgta gaacggcgag agccagacgg
      961 cgtccacgcc gaggtcgcgc aggtagggca ggcggctgcg gatgccgggc aggtcgccca
     1021 tgccgtcccc gttggagtcg gcgaagctgc gcgggtacac ctggtagatg accgcgtccc
     1081 gccaccagcc tctggacgcg ccggtgccgg cctcgtgagc ggtggcgtcg gcggcgggcc
     1141 gggaggtgtc ggccaggttc tgggtcatgg acggtatccc ttgggactag agagcggcag
     1201 gtcaggactt ggaggcgccg gcggtcaggc cggtgaccag gtgacgctgc accaggtaga
     1261 agaggaccga ggacgggatc gcgatcagta cggcggtcgc cgccatcagg ttccactggg
     1321 cgtcgtgctc gctgacgaag gtctgcaggc cgaccgccag ggtgtacttg tcggagctga
     1381 gcatgaaggt ggaggcgaag gccacctcgg cccatgcggt caggaaggag tagaacgcgg
     1441 ccacggccag gcccggcctg gcgagcggca gcaccagccg ccagaaggtg ccgaacgggg
     1501 agagtccgtc gacccggccg gcctcgtcga tctccaccgg gatggtgtcg aagtagccct
     1561 tcagcagcca ggcgcagtac ggcaccgtgg tggtcgagta gaccaggatc aggccgaggt
     1621 agctgtccag caggtcgagc tcggagagga tcgtgtacat cggcacgatc agcaccgcga
     1681 tcgggaacat ctgggtgacc agcagcgacc acatcagcgg cttgtggccg ggaaagcgca
     1741 tccgggagac ggcgtagccc gtggtggcgg cgatcagcac gccgaagacg gtggtgacgc
     1801 cggagaccag gaacgcgttg ccgaaccagg tgaagaagtc ggtgtcgaac agcaccgtgt
     1861 ggtagttcga cagcgtcatc ttgtcgagga tggcgcccgg gtggaggtag tccgtcttgt
     1921 ccgggccgag cgagacgtag aggatccaga ccaccgggaa gagcgcgatc aggctggcca
     1981 ggatcagcgc gccgtgggac agcgcgcggg cggccgggct cgcctgtccg cgcgggcgga
     2041 ccttgggcgg acggccggcc ggcggcgcgg gacgcgcggc ggcggtggtg ggtcggtcgg
     2101 tggtggtgct catcggggta cctgccttcg tggtcgctgg ggggacgggg cgtcagccgt
     2161 tggcctgctc gttgcgggcc agccagcgcc ggtagaaggc ggtgaagacg atcaggatgg
     2221 agagcaggat cacgccgtac gcggcggact gcgcgtagtc ccggggctgc tggccgaagc
     2281 cgagccggta ggcccaggtg accagcagct gggcgtcggg cgcgccgttg ccgccgaaca
     2341 gcaggaagat gacggcgaac tggttgaacg tccagatcac gccgagcagc accacggtcg
     2401 aggagacggt gcgcagcccc ggcagggtga cgtggcggaa ccgctgccac ggggtggcgc
     2461 cgtccatctc ggccgcctcg tacagctcgg ccgggatcga ctggaggccg ccgagcagcg
     2521 agatcatcat gaacggcacg ccgacccagg tgttgaccag gacggcggcc gccttctgcg
     2581 ccaacgggtc gtccagccag ccgggttcgg gcaggtgcag ggcggagagc aggccgttga
     2641 cggcgccgcc gtcggcgagc atcagccgcc aggagaagac ggtgacgaag gtcggcacgg
     2701 cccagggcag gatgagcagc atccggtaga cggcgcggcc gcgcagcttc tggttgagca
     2761 gcagggcgag gccgaggccg acggtgtagt gcaggcagac gcagatcgcg gtccaggcga
     2821 tggtccagac gaagtgcgac cagaagcggt cgtacgagcc cgggccccag aggatgtccg
     2881 cgtagttgtc gaagccgacg aacttgtagc tggccgggat ctcgttgacg ccgatcttgc
     2941 gggcggcgtt gaggctgttg gcgtcggtga gggtgagcca gaggccctcg gcgagcgggt
     3001 agagcaccag tacgcccagc acgatcacga ccggcgcgat catcgcgtag gcgtaccagt
     3061 gcttggcgta cgagcgcttg aggcgctcca tcaggcccgg acgcggatcg cgctcccggc
     3121 tgccctggcc ggtggcgccc tgcacggcga ctgacatgtt cgacaccttc tcggggaggt
     3181 ccgccgcctc gctacggcga ctgctgctac gggtctggcc gcccggcccg ccgggggtgg
     3241 cgggccgggc ggctcgggtg actacttggc gaagcccggg aggagcttgg cgtagtcggt
     3301 ggcgacggtg ttcaggccgt cctgggtgcc ggtgccctgg accaccttgc cgaggttggt
     3361 gcccagcgag gcgaacagcg agctgtactc ggccagttcg gggcggggac gggcgctggt
     3421 gagcacgctc tggaagccgg cgatgccggg gtcggccttg acctcggggg tgaaggcgtc
     3481 ggcgcgggtc ggcagggtgg agttcttctg cgcgatgaac gcctggctct ccgcggaggt
     3541 catgtaggcg gcgaacttct cggcggcggc cttgtgggcc ttgtccgagc cggcgtagac
     3601 ggagatgttg tggccgccgg tgggggcgcc ggccttgccg gcggagccgg ccgggacggg
     3661 ggcgatgccg aggttggtct tgtcggcgaa cgcggtgccc ttgtagatgt tggtgatctc
     3721 ccaggggccc tggatgatcg ccgcgacctt gccgctgttg aaggcgtcca tcatgtgcgc
     3781 gtaggcgtcg ctggtgacgt cggccttggc ggtgcccggc gcggtgaaca tcgtcttgta
     3841 ggtctcgatg cccttgacgg cctcgggcga gccgatggtg atcttcttgc cggcggcgtc
     3901 gacggtgtcg gtgccctcgc cgaacaggaa cggcatcgcg tagtagccgt cggcggcctt
     3961 cagccagaag ccgtccacgc cggccttctc cttgacggcg gcggcagcgg tcttcagctc
     4021 gtcccagctc ttgggggcgg cggtgatgcc ggccttggtg aagagctcct tgttgtagag
     4081 caggccgagg gtgtcggtga ccagcgggac tccgtacagc ttgccctcgt acttggcctg
     4141 ctggacgagg ctgggctgga aggcgccggc gtcggcggcg gccgcggtgc cgtccagcgg
     4201 ctccaggtag ccggccttgg cgaaggcggc ggtccagccg acctcggagc ggaacacgtc
     4261 cggagcgccc ttggccccca tggcggtctg gagcttgttc tgcgcctggt cgaacggcac
     4321 gttgacgaag tcgaccttga cgttcgggtt ggcctcttcg aacttcttga cgagggcctg
     4381 gtagttcggg gcctcgttgg tggcgttcga cgtgtcccag tacgtgaggg tgaccggccc
     4441 gtcggccttg ccgtccgagc tggagccgct gctgccacag gcagccatcg agaccgcgag
     4501 ggccacaacg agggcagagg ccgcgatgcc acgccgcatg agaactcctt gggaggggtg
     4561 ggggtgcccg agatgttggg aggcaggcgc ataatggctg cctcgtgccg accgcaccgt
     4621 tgctgccgtc gggctcggaa ggaagttaac agcggcgcaa tcgccacgga aagtccttgc
     4681 agcaagtttc tgcaagaaat ggggatcgtt acgcccgcgt gtcctggacg tggccgcacg
     4741 gtagtcgaca gacggccaag gcgtggcggt ttgtccgttt cgtatcgata gggaccccgc
     4801 tcattaatac gctgggttgc cgaaaggcct tgcagcagac tggtcccatg cgaatcagag
     4861 ccgccaccag ggaagacctg ccactgctgc gcgagctgga acgggccgcc ggggcaccgt
     4921 tcaccgccat cgggatgccg gagatcgccg aggacgagcc gcccaccgtc gaggagctgg
     4981 cccactacct ggacgggggc accgccctgg tcgccctctc cgacgagggc ggcggacgtg
     5041 ccgggggcga cgcggacgac gggcgtgccg ggggcgaaga gggcgaacgc ggcacccccg
     5101 tcggctacct gctggccgag ccggtggacg gcgccctcca catcgagcag gtctccgtcc
     5161 accccggcca cgcgcgccgc ggcatcggcc gggcgctgat cgagcacctg gcggccacca
     5221 ccgacgcgcc cgccctgacc ctcaccacct tcgccgacgt cccgtggaac gccccctact
     5281 acgcccgctt cggcttccgg ccgctcgccg acgccgagat caccccgggc ctgcgggaga
     5341 tccgccgccg cgaggccggg cacggcctcg accgttggcc gcggctctgc atgcgcaggg
     5401 agatcggcgc ggggctcagc tgacgcccag ccgcagcacc gtggtcgagc ggaactcctc
     5461 ccccggccgc agctcggtgc tggggaaggc ggggtggtgc ggggagtccg ggaagtgctg
     5521 cgtctccagc gcgatcccgg cgaacggccc gtacggcacg ccgctcgcac cggtcacggc
     5581 gccctggaac ttgttggcgg tgtagacctg cacgcccggc tcggtggtca gcacctccag
     5641 ggtgcggccg ctggcagggt cctccagcag cgccgcccgg gccggggtgc cgtcggccgg
     5701 gcgcgggcgg agcacccagt tgtggtcgta gccgccggga ccggtcagct gcgggtgctc
     5761 gtcctgcacc gacttgccga tcggccgggg ggaggtgaag tcgaacggcg tgccggccac
     5821 cggctccgtc cgcccgtacg ggatctgccg gtggtcggcg ggggtgtact cgtcggcgtc
     5881 cagggtgagc aggtgaccga ggacgtcgcc gctgccctcg cccgcgaggt tgaagtacgc
     5941 gtggttggtg aggttgagga cggtcggcct gctggtggtc gcgcggtagc cgatcaccag
     6001 ctcgccggcg gcgctcagcg tgtagtcgac ggtgacgtcg agcgcgccgg ggaagccctg
     6061 gtcgccgtcc gggctgtgca ggtgcagccg gacgccgtcg ggcagcggct cggactccca
     6121 catccggtgc gcgaagccgt ccggaccgcc gtgcagggtg acgccgcccc cggtcggggc
     6181 gagcgggtgc tcctcgccgt cgatggtgac cttgctgccg tcgatgcggt tggcgtaccg
     6241 gccgaccacc gtgccgtagt gccgggccgg gccgaggatc tcggcgagcc ggtcgctgga
     6301 gagcagcacc tgggcggggt ggccggtgcg gtcgggggcg gtcagggagt gcagggtggc
     6361 gccgagggtg agcacggtcg cctcgtacgg gccggcccgc agcgtccagc gctcgatcgc
     6421 ggcgcccgcg cccgcgggtt cgagcggttc gcgccgcaca ctggtcgcct gcgacccgtt
     6481 cgccgggggc gtcgccatga cctgctcctc actggcggcc gcggtgcgcc gcggccccct
     6541 ggtaccgggt ccgtccgggg ccagccgccc cgtgggcaag cctagtcagc ggggcgtcgg
     6601 cgggggcgct cctgccgccc cgcgcgccgc cgtcaggctt ccgcccgccg tcgtacctcc
     6661 gcccgccgtc aggcttccgc cgtaccgccg tcccggccgg ccgcgccctc gcgcccgtcc
     6721 tcggtgccgt cgcgctgctc gggcggcagg ccgagcgccg aggcgagccc gtccgggccg
     6781 ctgcccgcct tgcggtagac ggcggccagc cgccggttca ccaggctgag gtgcacgccc
     6841 agctcgtcgg cgatccgctg cggcggcacg ccccgcacgg cgagccgggc gacgtcccac
     6901 tcgggctggc tcagcatctc ccggacgtcg ccgagacggt tgggccgcag gccgtagttg
     6961 gccagctcgc ggcgggcccg gtcgaccagg ccgtcggcgg cgcagtgctg ggccagttcg
     7021 atgccctggt agaggtactc ctgcgcgtcc tccagccggc cgacccggcg cagcgccgca
     7081 ccgaggtcca ccagcgcgac ggcgtgctcg tagccggccg gcgactggcc gaggtggcgc
     7141 acggcctcct ccagcagctc gaccgcctgc tggccgtccg cgatctcggc gtgcagccgc
     7201 aacgcggtgc cgatcgccga ggcggtaccg aaccggcggg cgtcccggac ggaccgctcc
     7261 gcgtacgcgc gggcccgctc gggctcgtcc tcggcgagcg cgaccgcgag gtggccggcc
     7321 cagggcgccc agacggtgtt gtgccagccg cgggcgtcca gctgggcgcc ggcctcggtg
     7381 agggcggcgg cggccccggc gttgcggccc ttggcgagca gcagcttgcc gtagagggag
     7441 gccgcgtcgg gcagcaccat cgcggtggag tggtacggcg ggctgaagcc gaacccgatc
     7501 gcgaggtccc aggcctcgtt ggtgcggccg cgggcgatca gggtgtccac caggacgccg
     7561 accgcgtccc aggcgagcgg cagcttgggg ccgatccgct cggagagccg cagggcccgg
     7621 cgcaggaagt cctcggcctc ggcgagcagg ccacggcgga accgggccag gcccatcagg
     7681 aagtacgcga agccgcggtg ggcaccgctc cagcccgcga tctcgaactg gacgatgcgt
     7741 cgccgaagag ccgctcggcc tgcgcgatgc ggtcgctgta ggtgtacgag agaccgagcg
     7801 tggcgggcag ttcgaagccc caggtgctgt ccgtccagcc gaggcccttg ggcagccggc
     7861 cctggtcgag gacctggtcc gcgtggcgca gcacctcggc ggagggctcg ccgcgcaggg
     7921 tgaggtccca ggcgcgcagt gcgaggacgg cccggtcggc ggcctcgcgg ccggtgaggc
     7981 tgcggcagag cgcgcccagc cgctcggagc gggccggacc gtcctcctcg gacttgcggt
     8041 aggcgtgcca catgaacgcg gcggcctcca gccggagccg gcccgcggag tcgtcgtccg
     8101 tcttctcggc ctcgtcctgg cagacccgcg cggcctcgcc gagctggccg ctgtgcgcga
     8161 ggacctcgga gagccggaag gtggcgtcga cccggagcga ggggcgcagc ggcccctcgt
     8221 cggggtcgag ggcgagcttc agctggttga cggtggccat cgggtcggtg agcagcgcgg
     8281 aacagcccag ctcgtacagc acctcggcgc ggatgtcgtc gtccggcggc tcggcgaggg
     8341 cgcggtgcag gcagcgctgg gccgcctcgg gcgcgccgat cagcaggtgt tcctgggcgg
     8401 ccttgcgcag cttgcggacg gtgcggtcgt cgccctcgcc ggggaaggtc tcgaccaggt
     8461 gacgggaggc ggcgagcagt ccgagcccgg cgttctcgat ctcggcggcg gccaccccgt
     8521 gcatgccggt cttggtggac tccttcatgg tgttgtagat cgagctgccg atcagcgggt
     8581 ggacgaactc caggttcccg ttgggcgtct gggtgaggac gcgctgcttg cgcagctgct
     8641 tgatggactc gcgggagccc tccagggact gggtggagat ccgggcggcg aggtccggcc
     8701 ggatgtcggt gccgagcatg gcgcaggccc aggcgaaccg cagggtgctg gcgccgagcc
     8761 gctccagcca gccggtgagg gtcgtcccgg tggcgtccac ggcgagttcg cgcagctgct
     8821 gggagttctc ctcgaccggg tcgagctcct ggtcgcgcac ctggtccagc agggcgacgg
     8881 cctcgaacgg gttcccgttg acgacgttcc agaactcgta gcagaaggcg tcctcggcct
     8941 tgtcgccgag ttcggcgcgg accatgtcgg tgaccgagac cagggtgagc cggccgagtt
     9001 cgtgccggcg ggtggcgagg gaggtgacgg cggcctggtg ctcctgggcc tcgggctgcc
     9061 agtccgcgat gtcgtcccgg taggcgaaga ccagcaggac gggcagttcg ctcgcgcgga
     9121 gggcgaagga ggcgagccag gcgagcgatt cgaggtcgga ccagtgcagg tcgtcgacga
     9181 tcatcaccag cggcgcccgg cgcggggcga gctgggtcag gacgtagtcg aggccgtcgc
     9241 gcacgccctg cgggtcgagg cggcgggccc cggccttcgg ctgcttgagc cccatggccg
     9301 gaccgacgac ctcctcccag gtgcccatga cctgccggaa ctcggcgggg tcgaggccgc
     9361 cgaggacggg ctggagcagc tggcgcagga cgtggtacgg ctcgttggac tggcgctcgc
     9421 cgccgcgggc gaacaggacg gtggtgccct cgcggagctt ggcgatcctg cggacctcgt
     9481 gcagcaggct ggtcttgccg atgccgggcc ggcctgagaa ggtgagcagc tcgccgatct
     9541 cggtgccgcc ggcggcgaaa tcgcggcaga gcttctccac cgcggcctcg gccgagcgga
     9601 gttcggcgtc acggtcgcgc agcctgaccc ggtgcggaac ggtctccggc tcccgcccgt
     9661 cggcacccgc ccccgcccga aattcgtgtc cctgctcggt caccgtcgcg cctccgcctc
     9721 gccgtaccct gctcgtggag ccgaggttag cgccgtgggg ggcacgctgt cgggcattcg
     9781 cccaggctgg aacggagatt gagggttcgg acagcttgcc aagggcaatt gccctatatc
     9841 cctaacgtcc gatcattgca tcggatactc tacggccccc gagccgagtt gatcttgcca
     9901 tgccgaactg cgcaccgcgt tcagccgctc caatcccccc tcccccacga ccagcacagg
     9961 caccaccagt acccccaccc tccgccgcac cgggagtccg atgtctgacg acacctcact
    10021 tcagattccg ttcccgcacc gccgaagccc gcacggtccg cacgccgccg aactgcaccg
    10081 cgactggctg acccgccacc cgctgctccc ggacccctcg cacccctcct acgcgcactg
    10141 ggacgtcgtc gccctcgccg ctctcggcta ccccgatgcc gggccggacg aactcgccct
    10201 ggccgccgac ctgatgggct tctacttcct cttcgacgac cagttcgacg gacccctcgg
    10261 ccgccgcccc gccgaggtgg ccccgatctg cgagcggctc atctccgtcc tgcacggcgc
    10321 cgggcccgac ccctcctccg ccgtcgagac cgccttcgcg gacctctggg aacgcagcgt
    10381 acgcgggatg cccgcgcgtt ggcaggcacg cgccgcgtac aactgggagt ggtacctggc
    10441 cagccacccc gccgaggccg ccggccggat ctccgggcgg ccaccggacc gcgacggcta
    10501 cctggccctg cgccgcggca ccgccgcgat ggagaccatc ttcgacatgg tggagtgcct
    10561 cggccacttc gaggtgcccg ccgccgtact ccaccacccg gtgctccgcc agatccgcca
    10621 gctcgccgcc gacatcccct cgctcagcaa cgacgtccgg tcgttcccgc tggaggcgcc
    10681 ccgcggcgac gtcaacaacc tggtgatgat cgtgcagcgg gagcgccgct gctcggccga
    10741 ggaggcctgc gccgtggtga tggacgaggc ccagctgatg gtcgagcgct gccgcgagct
    10801 gtacgaccgc ctccccgacg tccaccgcga gctgggcctg tcccgggtgg agcgcaccgt
    10861 cgcccagcgc tacgccgacg gcctggtcac ctggctcgcc gggtacctca actgggagtc
    10921 ccacaccggc cgttacctcg ccgcctgagc ccgcccggct ccgcgtgacc ccggacgcac
    10981 gcccgcccgg gcccgggccg gcccgcgtcg gcgtgacgga aaacggccga ataagcaccc
    11041 tccgtggaag tcggctgtac ggaccgtagc cgcgcccgcc gtccgcggct agggtgccag
    11101 acggcgggcg ccccggcggc gcccggccca tgtgcgcgtc cgcaccctcc gccggaccgc
    11161 cgggccaccg gtccgcggtc cggcgcaccg cccggccccc gcgcgccgcg gcggtgcccc
    11221 ccgaccacgc gaggaggccc ccggagcatg acggtctacc agccccccgg cacccccgga
    11281 tccatcgtca actaccgccc ccggtacgag cactggatcg gcgggcggtg gacgccgccg
    11341 gtccgcggcg agtacttcga gaaccccagc ccggtcaccg gcgaggtctt caccgaggtc
    11401 gcccgcggca ccgccgagga catcgaggcc gcgctcgacg ccgcccacgc cgccgccccg
    11461 gcctggggcc gcaccgcgcc cgccgagcgc gcccaggtgc tgctgcggat cgccgaccgg
    11521 atggaggcga acctggaggc gctggccgtc gcggagagct gggagaacgg caaaccggtg
    11581 cgcgagacgc tggccgccga cctgccgctc gccgtcgacc acctgcgcta cttcgccggc
    11641 gcgctgcgcg cccaggaggg cggcctctcc cagctggacg aggacaccgt ggcgtaccac
    11701 ttccacgagc cgctgggcgt ggtcggccag atcatcccgt ggaacttccc catcctgatg
    11761 gcggtctgga agctcgcccc ggccctggcg ggcggcaacg cggtggtgct caagcccgcc
    11821 gagcagaccc cggcgtcgat cctggtgctg gtcgagctga tcgccgacct gctgccgccc
    11881 ggcgtgctca acgtggtcaa cggcttcggc ctggaggccg ggcgcccgct ggcctccagc
    11941 agccggatcc gcaagatcgc cttcaccggc gagaccacca ccggccgcct gatctcccag
    12001 tacgccagcg gcaacctgat accggtctcg ctggagctcg gcggcaagag ccccaacctg
    12061 ttcttcgccg acgtcgcggc cgaacaggac gccttctacg gcaaggcact ggagggcttc
    12121 gcgatgttcg ccctcaacca gggcgaggtc tgcacctgcc cgagccgggc gctgatccag
    12181 tccacggtct acgaccggct gctggccgac ggcctggagc gggtgcggtc gatgcgccag
    12241 ggcaacccgc tggacaccga gacccaggtc ggcgcccagg ccagcgacga ccagctgaag
    12301 aagatcctct cctacatcga gatcggccag gccgagggcg ccaaggtgct ggccggcggc
    12361 gaacgcgccg acctcggcgg gtcgctcgcg ggcggctact acgtgacgcc caccgtcttc
    12421 gagggcgtca acggcatgcg gatcttccag gaggagatct tcggcccggt cctcgcggtc
    12481 acccgcttcg aggacttcga cgacggcatc gccctcgcca acgacaccct gtacggcctc
    12541 ggcgcgggcg tgtggtcccg ggacggcaac accgcgtacc gggccggacg ggccatccag
    12601 gccggccggg tctggaccaa ctgctaccac gcctaccccg cgcacgcggc cttcggcggc
    12661 tacaagaact ccggcatcgg ccgggagacc cacaaggcgg tgctggagca ctaccagcag
    12721 accaagaacc tgctggtgag ctactccccc gacgccctcg gcctcttcta ggcccccggg
    12781 cgcgggcctc tgagcgcagg cctctgagcc aggcctccgg cgcgggcctg ccgggcgcga
    12841 cccgcccccg gcaggcccgc tgcggggccg cgccccgccc gggagcaccg ggcccgaaaa
    12901 cgcggagtgg gaagtcgggc cggccgactt cccactccgt taccactccc cgtggtccgc
    12961 ggccgggcac ccgggcgggg cgcccggccg cgtttctccc gagctcaccc gccgagcagc
    13021 cgcgccttgg cggtcgcgaa ctcctcgggg gtgagcaggc cctgctgggc catccggccc
    13081 agatcggcga gcttgtccgc gatgtccggc gccccggcgg acgcggtggg cacagcggga
    13141 acggcggacg cggcaggcac ggcgggcact gtgggcagcc cggacgcggt gggcacggcg
    13201 gacgcggcct gccccggctg cgcagccgcg acgaccgcga cggccggtgc ggccggtgcg
    13261 gccgttcccg ccggggcggc cacctgggcc tgcaacgcgg cgatcgcctc gttctggtcc
    13321 tgctcacccc ggcgccggcc ggccgcaccc cggccggccg cgtacgcggc accgcccacc
    13381 accagaccgc gcaccagggg cgcgcccacc ggccgcatca cccgcaccgg gcggatcggg
    13441 cgcagaggtc ggaacatggc gtcctcactt cccggccgcg cggtgcgcct cggcggcgcg
    13501 aacggcctcg ccgatgtttt ccggcgggat ccggacgccc gaggcgatcc gcccgccgat
    13561 ctcgcgcagc gcctcggcgg tctcctgcgc ccagacgtgt tcgatcagca ccagcagcgc
    13621 caccgtcccc ggcgccagca gctcggccgc ctcctgggcg tcctccggcc cgatcagcgg
    13681 cagttcggcg ctcccgtccg ggacgacgcc gcgcaggtgc tcgaagtcgg cgagttcccc
    13741 gtacgtcgcc tcgccctccg ggtgccgcgt caccaccagc gagtcgatca cccggacgtc
    13801 gccgccggtg cgcagcttgg cgagcgcttc ggcggcctcg atggtgatgg tctgctgcgg
    13861 gaacgtcagg acgagcagtt cggccggacc catccgggac tcccttctac gtgcaaatca
    13921 cccatagcgg atctaagcac acgaaaattg aaaatctccg acgcgccgcc gacattcccg
    13981 gacacgcccg ggcgacgcaa taaacaggag gtccctatcc ctcgtccccc tgggagaccc
    14041 catgaccatc gccgtcgcca agctgtccga cccggccgtc cgcgccttcg tcgccgcggt
    14101 caactcgggc gaccggaccg ccttccgcga tctgctcacc cccgacgcga ccatgtccga
    14161 cgacggttcc gaccgcgacg tcgacgactg gaccgagcgc gagatcttct ccagccacgg
    14221 ccacatggac gtccagtccg agtccgacgg cgggcacgcg ctgatcgcca gctacaacaa
    14281 cgacacctgg ggcgagatgc gcaccgcctg gcgcttcacc gtcgaccacg ggaagatctc
    14341 gcgcttcgag accggccagg cctagggtcc ggccctcagg cgggcagccc gaggcagccg
    14401 cgcaccgcgc ggatcaggtt ccgcgagcgg acgtcgcccg tgaccccggg ctgcatgccg
    14461 ttggtgacgt agccgaagcc cagcccgagg tcggggtcgg cgaagccgag cgagccgccc
    14521 cggcccgggt ggccgaagct ggccggcgag gccatcagcg aggtcgggcc gtgccggaag
    14581 aaaccgaggc cgaacgtcga gttgacgatc agcacccggt ccggcccgct gaccgccggt
    14641 ccgaccgcgc gggccagcag ctccggcccg aacagcgccg gcaggacctc gcccgccccg
    14701 ccgccgtgcc ggtcggccgc gccgaccagc gccgcgtaga accgggccag cgaacgggcg
    14761 gtgccgatcc cgcccgcgcc ggggatctcg gcggcctgga ccgccgggtc gttgaggtcc
    14821 accccgggac gcaccgaggc gaaggcgcgg gcggtcagcg aggccgggtc ctggtaggcg
    14881 tcccgcaccg cctgcttggg acgcagccgc agcccgctcg gccccgtccg ggcggcctcc
    14941 ggcgcgggca ggtccaccag ccggcccacc cgcggggcgg cgccggccgg cagcccgatc
    15001 cacaggtcga ggccgagcgg ccgggcgatc tcctcggcga agtactgccc gacggtccgc
    15061 ccgctcaccc gccggaccac ctcgccgacc agccagccga aggtgtaggg gtggtagccg
    15121 tgcgcggtgc ccggctccca ggcgggtgcc tgggcggcga cggccgccgc cgcccgctcc
    15181 caggtcagca cgtcctccag gcgcagcggc acgtccaggg cgggtacccc ggcctggtgc
    15241 gagagcagcc agctcaccgg cacccggtcc ttgccggccg ccttgaactc cggccagtac
    15301 gaggcgaccg gcgcgtccag gtcgagctgc ccgcggtcgg ccagcagcag cgcggtggtg
    15361 gcggtcaggc ccttggtgac cgagcgcagc acctgcgcgg tgtcggccgt ccacggcacg
    15421 gccggtgcgg gccgcccgcc gacctccggc cgggcgtcgc cgccccacag gtcgaccacc
    15481 ttgcggccgc gcacgtacag cgcgaaggcc gcgcccagct cgccgtactc ccggaagttg
    15541 cgggcgaagg cgtcgcgcac cggctcgaag ccctcggccg tcccgcccca gatctccacc
    15601 accgcgtgcc gcccagcctc gtccgaatgc gtaccgtgcc cgtgtccgga gtccgtgcgg
    15661 agttccgttc ggtgcgttcg aaccgggccc ggaaacccta acctgtccgt catgaccaac
    15721 cctgccgaag agctgctgga cgtcgtcgac gagcacgacc gggtgatcgg gaccgcccgg
    15781 cgcggggagg tgtaccggga cgggctgacc caccgctgcg tcttcatcct ggtccgcgac
    15841 ccggccggtc gcatcttcgt gcaccggcgc accgacacca agctgttcgc ccccggcgcg
    15901 cacgacatgt tcgtcggcgg cgtggtcggc gcgggcgagt cgtacgcgag cgccgccgtc
    15961 cgggaggccg aggaggagct cggcgtgcac gggatcgagc cggagccgct gttcaagttc
    16021 ctgtaccggg gcggcgggct ctcctggtgg tgcgatgtgt acgaggcccg ctgggacggc
    16081 ccggtgtcgc cgcaggagtc cgaggtcgcc tggcacgcct ggctcacccc ggcggagctg
    16141 gacgagcggc tggcgcgcga cgagttcgtc cccgacgggc tggaggcgta ccgccgctac
    16201 cgcgagctgc gcggatagcg cggccggata gacacctcac ggcgccaagc cgtcaagccg
    16261 gtggccgggt ggagcgtggg gcggtcgaac agagctgatc ctcgtacgcc agaatcgcgg
    16321 catggcgatg gcacggcgct ggtactcctc ggctcccgtt gtggacggcc tcccgctgct
    16381 ggacgggccc ggattttggg ccgcgcacct ggtcgacctg tgcgagggcg agtcggccct
    16441 tatctggggc tcctaggcag tttgagcatg tcagcgtgca tctggagttg tcagggatgt
    16501 aaggcacgta gtcgaggctc cgatgcgacg tgtcctgtgc cgcctacgtt ctccacacac
    16561 tgtcaccgtg gccttcaccc gcctgtggct cgcccatgat cggcgggcgg ataaagcggt
    16621 ggtcgtctga ttggcttccc tgccacgatc tgggtgtgac tacgttgctc ctgatggtcg
    16681 gcctgccagg ggccggaaag accacgcggg ctcggcagct cgccgcggag tacggcgcgc
    16741 tgcgtctgac gcccgacgac tggatgattc ccctgttcgg cgaggcggag gcagacggga
    16801 agcgcgacgt gctggagggg cgcatgctct ggctcgcctt ggaggcggtc aaactgggca
    16861 ccaacgtcgt cgtggactac ggctgctggt cgcgggacga acggtctgcc atccgctggc
    16921 tggtggaggc cgaggaggcg tgcttccgca tggtctacct gccggtggac gatgagaccc
    16981 agcgcgcgcg tattgcccat cgctgggcga ctgcccccga ggagacgttg ccgatgtccg
    17041 aggccgacat cctgcacggg cgggcgcatt tcgaggagcc cgacgcggcg gagctggagg
    17101 gccgcgggac cgctggcccg ccgcccggct gggtgggctg gcgggagtgg gccgccgcca
    17161 ggtggccgtc gttcgcgtga ctgctgcgac ccacgacagc gcagccgtag cgagcgtgcc
    17221 ctcaccaggc cgaaatgttc cccgctggac gagaattgac gttcattccg ttggcctcgt
    17281 tcagcgcggg gctgccgatg ggcgccccgc tcatccatcg tgaggagacc tggcttgacc
    17341 ctctcatggg atctgctgat atccaccgca ggtggtgtca ccgcaacggt cgtgggcgtc
    17401 atcgccggcg gtgtcatcgg acgccgcggc cagcaccagc aatggctgca ggggacgcag
    17461 accgccgcct acgagaagtt cctgcaggcg ttcggggccg tggaggcgga gctgcgcgag
    17521 gcattcctcg acgagcgcag gcccgccgtc gactgggtgc cgttcgtggc cgcccagcac
    17581 tcggtcagcc tcgttgccga cccggcgacc agtgcagcag ccgagcgggt ctgcgagatc
    17641 ctggaggact tcaccatcct cttccatggg cgtcagccga ccgacatcga agaactgcgg
    17701 ccgattcata ccgcgctggg tgaggctcac ctgagcttcg tcaatgcggc ccgctgttcc
    17761 cttgccccgt cccaacggcg cttggaccga tcactgggcg gcccctcacc ctggcggggc
    17821 gtcgagtcct tctacacccg acctgacaga agcctcgact gagccttggc agggtgtccg
    17881 actgggagga cgttctgggc cgctctgccc gattgtcggc ggactggcgg aatcgttgag
    17941 ggggtgacgg tcaggtcgag ccgcgcggag cagtagccgt cgagcgcggt ggctcgctcg
    18001 tcgcatcggt gacgacgctg tgaaatccag cgtcactcca ggtccttgag catcagcgtg
    18061 cacgtcgccg tcgcggccgg caccgcagtg ccgtccggca actcccgctc cggcaacggc
    18121 gcacccactt cctgaccagg gcgccgagca cgcccgccgc tgacgtgccg tacgtgcctg
    18181 acgaacccct ggatatctgt aaggcacgga ctgatcaggg ccacttgccg tacttgtctt
    18241 acggcccctg agcaccccgg ataacgccgc gggaaagctg cagatgatct cggcgtccgg
    18301 gtgctgcggg aacacctcct cgacggcctg ggcgaggtcg tcggcggcgg tgcaggcagc
    18361 cgcgagctgg cccaggagag cgagcgtctg ctggccgagc gcgtcctcga ccagcggggg
    18421 ctggtgggcc cagtcggcgc gaaagacctc gcgcagtcgc tcgacctcgg cctcgatgcc
    18481 gcgcttgcgg ccggccctct tgagggcggc cctcttgagg gcggcggcga gctgcgtgcg
    18541 ggtcagccgc gcggcctttg ccggggtggg ggctgtcttg aggatctcgc gggcttcggg
    18601 gcggcacagg ccgtttttcc acggctcgaa ggcggccaac gccgccgggt agtactcgcg
    18661 tagcagtgag cggagctggt tggccatctg ctgtttgttt ccagacggcg tcctgctggg
    18721 cgcgggcgag gacggcgacg gcgcgggcca ggccgctgtc gtcgggaaga ggccggtggg
    18781 cgtgcatgtc ggtgcgcagg atgttggcca ggaccagggc gtcgccgggg tcggacttct
    18841 tgcgggagac ggcgtggcgg tcgcggtagc gggcggcggc catcgggttg atcgcgaaga
    18901 ccttccgagt accggtccgc aggaccgcga ccagcaggcc acgggaggtc tcgatcgcga
    18961 tagggatcgg ggcatcctcg gtgtccccgt actcggcgag caggtccagc agcagcttgc
    19021 agccggccgc atcgtcggtg atgtgccgct tggccagcag ccggccggtg tcgtcgacca
    19081 gggcgacgtc gtgcgtccgg tcggcccagt cgatgccaca gtagatcaag ttgttccctc
    19141 ccagggcgcg atgtttgcgc tggtcacgag cgcatgcggg ccacgcagcg acctaattcc
    19201 aggactcggc catccagccg gtccgccacc tcactagccg ttcgtggcac cagcgcaccc
    19261 cacgggcctc ggtctcttgc gggagctcgg gcgactcggg caaaacgaga ggtcaccatg
    19321 cggtgggctc gcaccaccaa caccaacgag tgatcaagag cgtggtgttg acggtggtga
    19381 cggccgcgaa ggcgccggac gccgccgctc tgttcaaagg catcgacgcc tggcatcatc
    19441 aaggctttcc tccggcgccc acgcggccgc caccaccgcg aatgccgggg ccgcgcgccg
    19501 atctatccga aggcctcagc gacccgggtg gcgcgaggcg tcacgacctc ggcattcgaa
    19561 cggaccggca acagccccct ggctccaccg atccgctatc aacgaattag ggtggcgcgc
    19621 atggcctccc gtacgccgtc ggcgtcgccc acgtccgcgc gcccccgccg gagcaccgac
    19681 cggagcagcg accggaccac cggccccgac gccgggccgg ccggcggtac gggcgcggcc
    19741 aaggcggcgg gcaagggcgg cggcaagggt ggcgagaagc cccgccggcg gctgagcgtg
    19801 gacgagcggc gcgagcagct gatcgccgtc gcgctggagc tgttcagccg ccgcccgccg
    19861 gaggaggtgt cgatcgacga catcgcggcc gccgccggcg cctcccgccc gctggtctac
    19921 cactacttcc cgggcaagca ggcgctgtac gaggagtcgc tgcgccgggc cgggcgcgag
    19981 ctggccggcc ggttcgagga gccgcacgag ggcccgctct ccgaccggct ccaccgggtg
    20041 atgggccgct acctggactt cgtgcagagc cacggccccg gcttcgccgc actgctgcgc
    20101 ggcggctcgg tcgcggccag cgccgggacg tccgcggtga tcgacgacgt ccggcaggcc
    20161 gcggccgacc agatcctggc gcacctggcc ctcccctcgc ccagccctgg cgtgcggctc
    20221 accgtccgcg cctggatcgc caacgccgag atcacctcgc tggagtggct ggccgagcgc
    20281 tcggtgccgc tggaggagct ccagctccac ctggtccagg agttcgtcgc ctcgctgacc
    20341 ctgaccgccg cccgcgagcc cgcgctggcc gccgaattcg ccgggttctt cgccggggaa
    20401 cgccccgacg gcccggccgg gcggctcgtg cgcgacctcg ccgggctgtt cgccgtcccg
    20461 ggcatcgcgg acgccgtcgc cgcgctggcg gccgagccgt cggactgacg gaccggccga
    20521 ccggccgacc ggccggcgga ccggaaaact gacgggccga cggactccgc ggaccgcgga
    20581 ccggccggct ccgcggccga cggaccgacc gccgccggcc ccgccggacc ggccgccggt
    20641 tctgccccga ccgcggcctc tgataggaat gtccacggat ccgacggcgc atccggtcac
    20701 cggcgcgccc ggaccaccgg accaccgaac gcagacgcag cagagcgggg ggctcatcag
    20761 ttgacccagg acggccagtt caccgcggag accaacccct tcgccgccgc ggagcaggtg
    20821 tccgcgacgc tcggcgcgct caccgaggcc cttctcgcac cgcacgcctc ccgccacccg
    20881 gcggcctcgc tgaccacgct gcgcggcggc acccacccgt cggccgagtc gctgttcaac
    20941 ctgcggct
//
