LOCUS       NZ_CP026498            21395 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. CB01881 chromosome.
ACCESSION   NZ_CP026498
VERSION     NZ_CP026498.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB01881
  ORGANISM  Streptomyces sp. CB01881
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     A 3-hydroxy-3-methylglutaryl-CoA synthase gene based probe for the
            discovery of the acyltransferase-less polyketide synthases
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) Xiangya International Academy of
            Translational Medicine, Tongzipo, Changsha, Hunan 410000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002953255.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 02:39:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,978
            CDSs (total)                      :: 7,904
            Genes (coding)                    :: 7,565
            CDSs (with protein)               :: 7,565
            Genes (RNA)                       :: 74
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 124 of 339
            Pseudo Genes (incomplete)         :: 251 of 339
            Pseudo Genes (internal stop)      :: 10 of 339
            Pseudo Genes (multiple problems)  :: 45 of 339
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:44:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 551575
            Orig. end                         :: 572970
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026498.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21395
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="3"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21395
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21395
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11395](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11395
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    107..126
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.8"
                     /tool="antismash"
     gene            complement(135..968)
                     /locus_tag="C2142_RS02635"
                     /old_locus_tag="C2142_02600"
     CDS             complement(135..968)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (11-223). E-value: 3e-37. Score:
                     120.2. Matches aSDomain:
                     nrpspksdomains_C2142_RS02635_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735593.1"
                     /locus_tag="C2142_RS02635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02600"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_148640886.1"
                     /transl_table=11
                     /translation="MNHDAYATLRVSREDGIARVTLDNPPVNVLNVALMADLRHLLTAL
                     KDDDSVRVIVFDSADPEFFIAHVDMSLVDTPDAFDRLAADLPDGVNVFQALGELLRHQP
                     QVTIVKLAGTARGGGAEFVTAADMAFAAIGRAGIGQIEALMGIVPGGGGTQYLAGRVGR
                     NRALEAVLGADLYDAETAERYGWVNRAVPADELDDIVDRLARNIAALPEGVIAAAKRAI
                     VPEDLAEGLLREHDAWAGQVGRPAAERLIRGGLAHGAQTSDGERDLEGLLRGLAG"
     aSDomain        complement(300..935)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS02635_ECH.1"
                     /evalue="3.00E-37"
                     /label="C2142_RS02635_ECH.1"
                     /locus_tag="C2142_RS02635"
                     /protein_end="223"
                     /protein_start="11"
                     /score="120.2"
                     /tool="antismash"
                     /translation="SREDGIARVTLDNPPVNVLNVALMADLRHLLTALKDDDSVRVIVF
                     DSADPEFFIAHVDMSLVDTPDAFDRLAADLPDGVNVFQALGELLRHQPQVTIVKLAGTA
                     RGGGAEFVTAADMAFAAIGRAGIGQIEALMGIVPGGGGTQYLAGRVGRNRALEAVLGAD
                     LYDAETAERYGWVNRAVPADELDDIVDRLARNIAALPEGVIAAAKRAIV"
     misc_feature    complement(997..1011)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     gene            1092..1481
                     /locus_tag="C2142_RS02640"
                     /old_locus_tag="C2142_02605"
     CDS             1092..1481
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735592.1"
                     /locus_tag="C2142_RS02640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02605"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_148640887.1"
                     /transl_table=11
                     /translation="MATSETGAAAGIDIVYRSDCPSRPILDQIADKWSMMVMAVLEKPT
                     RFNEIKRRLEGVTQRVLTQTLRRLERNGMVVRRVLPTSPVGVEYSLTPLGESLREPFGR
                     LYDWTVDNADEIRAHQMDYDQRVQS"
     gene            complement(1717..2295)
                     /locus_tag="C2142_RS02645"
                     /old_locus_tag="C2142_02610"
     CDS             complement(1717..2295)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020556693.1"
                     /locus_tag="C2142_RS02645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02610"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_148640888.1"
                     /transl_table=11
                     /translation="METATPRLKDASLTRERILTAARREFARTGFARTTVRAIAASAEV
                     SPNLITRYFGGKDGLFVAATEVRLELDRRFDGPRHSLGHRMARGIVDRWTGMEGEDPLL
                     VLLRAAGERGEAAEALSTFLDRESLEPLRQLLLRYGMTEEEAHARARAVDVFVLGISAR
                     LRVLRDDLGDSEELERWIADTIQRLVDAP"
     misc_feature    2325..2338
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.33"
                     /tool="antismash"
     misc_feature    2326..2341
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            2363..3433
                     /locus_tag="C2142_RS02650"
                     /old_locus_tag="C2142_02615"
     CDS             2363..3433
                     /NRPS_PKS="Domain: Abhydrolase_1 (89-193). E-value:
                     1.5e-17. Score: 56.0. Matches aSDomain:
                     nrpspksdomains_C2142_RS02650_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006144356.1"
                     /locus_tag="C2142_RS02650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02615"
                     /product="epoxide hydrolase family protein"
                     /protein_id="WP_148640889.1"
                     /sec_met_domain="PF00561 (E-value: 7e-13, bitscore: 47.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLPFSPVTDSALDDLHRRLAATRRPLLARAAGWERGADADFLAR
                     LLDSWRERYDWRAHEARILDLPWETVGSGDRALHLVHQRAAADAPVVVLLHGWPDSVLR
                     FERVLPLLEDLNVVVPALPGFPFSHESARPGMTTTAMASLVTDATRALGYGRYVVSGGD
                     VGADVAEQLAAMHPDRVAALHLTNVSPLHAVFADRSALGAEELAYLDTAAAWQRAEGGY
                     IAQQSTKPHTLAPALADSPAGLGAWICEKLWSWSHIPFEEEVLLTWISVYWFTNTIGTS
                     FTPYAEVAPPVPYVATPTVLSAFSHDTKPAPRCFASRFVNVREFIEHENGGHFAAWEQP
                     LHYAEDLRRAVGLADW"
     aSDomain        2630..2941
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS02650_Abhydrolase_1.1"
                     /evalue="1.50E-17"
                     /label="C2142_RS02650_Abhydrolase_1.1"
                     /locus_tag="C2142_RS02650"
                     /protein_end="193"
                     /protein_start="89"
                     /score="56.0"
                     /tool="antismash"
                     /translation="PVVVLLHGWPDSVLRFERVLPLLEDLNVVVPALPGFPFSHESARP
                     GMTTTAMASLVTDATRALGYGRYVVSGGDVGADVAEQLAAMHPDRVAALHLTNVSPLHA
                     "
     gene            complement(3594..3998)
                     /locus_tag="C2142_RS02655"
                     /old_locus_tag="C2142_02620"
     CDS             complement(3594..3998)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543865.1"
                     /locus_tag="C2142_RS02655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02620"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_148640890.1"
                     /transl_table=11
                     /translation="MATTTAAQRRAAERAGFDAYLAECPARQLLDRIGDKWVSLVVNAL
                     ADGPLRYSDLRRRLAGVSEKMLTQTLRALERDGLLTRTVTPSVPARVDYALTPLGTGLL
                     PLMQSIKAWAEQNMPEVLAAREAYDDARED"
     misc_feature    complement(4067..4085)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: medium, score: 26.86"
                     /tool="antismash"
     misc_feature    complement(4068..4084)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 23.15"
                     /tool="antismash"
     gene            4123..5058
                     /locus_tag="C2142_RS02660"
                     /old_locus_tag="C2142_02625"
     CDS             4123..5058
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (14-192). E-value: 4.8e-31.
                     Score: 100.0. Matches aSDomain:
                     nrpspksdomains_C2142_RS02660_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004947654.1"
                     /locus_tag="C2142_RS02660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02625"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_148640891.1"
                     /sec_met_domain="ADH_N (E-value: 5.7e-06, bitscore: 25.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVVVRTFAGPEALELVDVPVPEAGPGQVRVRVEAAGVNPVDAV
                     TRAGVLAQAGLMPPREVVGIGWDVAGVVDRVGPGVAGFAPGERVIGLRDRLDAPLGSYA
                     EYLVLDASVLAPAPAGVPAVEAATLPLNGLTAVQALDLLGLPAGATLLVTGAAGAVGGF
                     AVELAVLRGLRVVALAGEEDEALVRELGAEWFVPRGTADPAAAVRSLVPGGVDGALDAA
                     LLGVVALGAVRNRGAFVAVSGGAPVGLRGIRVTNVWIAADGRALAGLSDLAARRRLTLR
                     VADALPLEQAAEAHRRLDRGGLRGRLVLVP"
     aSDomain        4165..4698
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS02660_PKS_ER.1"
                     /evalue="4.80E-31"
                     /label="C2142_RS02660_PKS_ER.1"
                     /locus_tag="C2142_RS02660"
                     /protein_end="192"
                     /protein_start="14"
                     /score="100.0"
                     /tool="antismash"
                     /translation="LELVDVPVPEAGPGQVRVRVEAAGVNPVDAVTRAGVLAQAGLMPP
                     REVVGIGWDVAGVVDRVGPGVAGFAPGERVIGLRDRLDAPLGSYAEYLVLDASVLAPAP
                     AGVPAVEAATLPLNGLTAVQALDLLGLPAGATLLVTGAAGAVGGFAVELAVLRGLRVVA
                     LAGEEDEALVRELGA"
     CDS_motif       4222..4269
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C2142_RS02660_0001"
                     /evalue="3.20E+01"
                     /label="PKSI-ER_m2"
                     /locus_tag="C2142_RS02660"
                     /protein_end="49"
                     /protein_start="33"
                     /score="-1.5"
                     /tool="antismash"
                     /translation="VEAAGVNPVDAVTRAG"
     CDS_motif       4315..4353
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C2142_RS02660_0002"
                     /evalue="2.30E-02"
                     /label="PKSI-ER_m2"
                     /locus_tag="C2142_RS02660"
                     /protein_end="77"
                     /protein_start="64"
                     /score="7.9"
                     /tool="antismash"
                     /translation="IGWDVAGVVDRVG"
     CDS_motif       4567..4626
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C2142_RS02660_0003"
                     /evalue="1.00E-02"
                     /label="PKSI-ER_m5"
                     /locus_tag="C2142_RS02660"
                     /protein_end="168"
                     /protein_start="148"
                     /score="8.7"
                     /tool="antismash"
                     /translation="ATLLVTGAAGAVGGFAVELA"
     gene            complement(5153..5416)
                     /locus_tag="C2142_RS02665"
                     /old_locus_tag="C2142_02630"
     CDS             complement(5153..5416)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS02665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_02630"
                     /product="hypothetical protein"
                     /protein_id="WP_148640892.1"
                     /transl_table=11
                     /translation="MDSGGTNETAETASEERELSTGAMVAVTVLAAVGAVAVMLAVFHW
                     LGWTFPGLGWLLAKGAVKLCAGGAVGLVAAVAWLRQQRSGRR"
     gene            complement(5438..5821)
                     /locus_tag="C2142_RS02670"
                     /old_locus_tag="C2142_02635"
     CDS             complement(5438..5821)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS02670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_02635"
                     /product="hypothetical protein"
                     /protein_id="WP_148640893.1"
                     /transl_table=11
                     /translation="MSTNLPETVAEGPALLPAPPRVVDDLARDLTHAAAAVRAVSRAGR
                     SCGDIAVAAYTAVVCTGRSAARALEEAAAWCRQAPEAEVHSLAWARVPGHRDDVFEYRV
                     TLAVSFPDHETGEHTGDTHHAPR"
     gene            6291..6956
                     /locus_tag="C2142_RS02675"
                     /old_locus_tag="C2142_02640"
     CDS             6291..6956
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS02675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_02640"
                     /product="hypothetical protein"
                     /protein_id="WP_148640894.1"
                     /transl_table=11
                     /translation="MQLKSPLQYGRRHLWLPALALAGAALAGCSSGSGGGSAAPSTGSA
                     ASTPAAAPTTAAPVPTSAASTPAAPATTAAPTGTAAKRPADACTLLNSPQVIAAVGTGG
                     PFTGTHPDPASDGSPVWGCTWGSRQSYASIREVKPTVLATVKANPDNQITPVPGAGQEA
                     VLTQRKDGTHPEVYFVADGRTYSVEVVKDRGPGDNVNAPAEALAESGLALVFAKALAG"
     gene            complement(7530..7757)
                     /locus_tag="C2142_RS39150"
     CDS             complement(7530..7757)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS39150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_241002333.1"
                     /transl_table=11
                     /translation="MDDGTGVSSARCQRTLPSAAPTPYTWLVSVATATVEPATSGCAYT
                     APSTAVDQRRPKSEAETCAGLRPGSAVSQA"
     gene            7796..8968
                     /locus_tag="C2142_RS39155"
     CDS             7796..8968
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS39155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_241002334.1"
                     /transl_table=11
                     /translation="MYDKATGTVYLVTKSNEGGAHFSVHALDVTSGAERSGWPVPVQGD
                     PVNSPGVPFNAATSAQRAGLLLLDGAVYFGFASDCGVGTYVGHVGGVNTTSRKLTLWST
                     ESGSNSQNGGVWMSGGGLVSDGAGRIILATGNGAGTGSSPAKGPGNKPGSHFADSVVRL
                     GVNSDGSLAPKDFFSPANNRDLDHNDLDLGSGGPAALPSGFGTTSHPHPHLLVQVGKDG
                     RIFLLDRDNLGGTVQGPNGTDAVVGMTGPYKGVWGHPGVWGGGGYVYVIENYGSLRALK
                     YSVNGSGAPQLTSAGTSAEGFGYASGSPVVTSNGTAGGSALVWLIYSGTGPGGQNGELR
                     VYDPVPVNGTLKMRRSFALGTVTRFSVPATDGGRVFVGTKDGHLISFGRA"
     misc_feature    complement(7827..7841)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.69"
                     /tool="antismash"
     gene            9160..9318
                     /gene="pqqA"
                     /locus_tag="C2142_RS02685"
                     /old_locus_tag="C2142_02650"
     CDS             9160..9318
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: protein motif:HMM:TIGR02107.1"
                     /locus_tag="C2142_RS02685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02650"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_148640895.1"
                     /transl_table=11
                     /translation="MKCTTTPRPAPAVPAERPAGAATAAKPAWTTPAVECHRAGAEVTA
                     YAARTTR"
     gene            9315..10004
                     /gene="pqqC"
                     /locus_tag="C2142_RS39160"
                     /old_locus_tag="C2142_02655"
                     /pseudo=""
     CDS             9315..10004
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /inference="COORDINATES: protein motif:HMM:NF015057.4"
                     /locus_tag="C2142_RS39160"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02655"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTQPLTRERFAARLYDLRGRYWDTHPFHLRLHSGGCTPPELRRWV
                     ANRWYYQLCLTRKNAAIIANCPLPEVRRSWVERLAYQDGPSGDEGGLAD"
     gene            10001..11395
                     /gene="pqqE"
                     /locus_tag="C2142_RS02700"
                     /old_locus_tag="C2142_02660"
     CDS             10001..11395
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PqqD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR02109.1"
                     /locus_tag="C2142_RS02700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02660"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_148640896.1"
                     /sec_met_domain="PqqD_RRE (E-value: 5e-18, bitscore: 63.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.2e-09, bitscore: 37.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.9e-20, bitscore: 72.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.4e-07, bitscore: 30.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.3e-09, bitscore:
                     36.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPARTDQVPGLRRGVRMVHDPVRGRGVLLYPEGVLLLNETAAA
                     VLRHCDGRRGTDGITAELTTEYDGVDPDQVRALLAELAGRRLLALDGTGAPAEPRQAAG
                     LPGAPVRPPAPLGLVAELTHRCPLQCTYCANPIELTCQRDELETEQWLRLLDQARGLGV
                     LQVHLTGGEPLLRRDLDRIIGHAHHLGLYTNLVTSGLPLDAERTAELADAGLDHVQLSV
                     QDADLHRADAVAGLAAHRRKLAAAALLTGAGLPLTVNAVLHRGNVARIGALADLAVELG
                     ADRVELAHTQFYGWAWRNRAHLAPSGEQVRQAERDVAAARERHGDRIEIVHVTADHHGD
                     TAKPCMDGWGRRQLVVAPDGDVLPCLAAAQLPGLPVPSAVTDGLAAIWHDSPAFNRYRG
                     TDWMPEPCRSCALREVDHGGCRCQAFQFTGDPGATDPACHLSPHHHLVAGPAPAGAPPP
                     VPRRMR"
     aSDomain        10019..10267
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C2142_RS02700_PqqD_RRE.1"
                     /evalue="1.80E-20"
                     /identifier="RREFam006.1"
                     /label="C2142_RS02700"
                     /locus_tag="C2142_RS02700"
                     /protein_end="89"
                     /protein_start="6"
                     /score="63.5"
                     /tool="antismash"
                     /translation="TDQVPGLRRGVRMVHDPVRGRGVLLYPEGVLLLNETAAAVLRHCD
                     GRRGTDGITAELTTEYDGVDPDQVRALLAELAGRRLLA"
     gene            11431..12300
                     /locus_tag="C2142_RS02705"
                     /old_locus_tag="C2142_02665"
     CDS             11431..12300
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="C2142_RS02705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02665"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_241003103.1"
                     /transl_table=11
                     /translation="MPQWNCGCAGCTTARRTGAARSQDCLAVSADGAAWYLVNASPDLR
                     GQLLAAPELAPSPGTRDTPLRGVLLTSGELDHTLGLLTLREAAELTVHATLPVRYALHS
                     AFPAGPLLAPYTKAGWQTLTPGRTVELAGGLRAEPLALGGKRPRYAADLPGEGWEGRPD
                     WVTGFRFTDADGRASAVYAPGLAEWTPAMDRAVAGADVVVLDGTFSTDDELAGHTGGSR
                     SSRGMGHLAVLDSLPHLARHPGPRYLYTHLNNTNPLAHPGSPGTEALARALAAAGAAVA
                     EDGMLIEF"
     misc_feature    complement(12452..12465)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.93"
                     /tool="antismash"
     misc_feature    complement(12455..12468)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.72"
                     /tool="antismash"
     misc_feature    complement(12458..12478)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.02"
                     /tool="antismash"
     gene            12557..13963
                     /locus_tag="C2142_RS02710"
                     /old_locus_tag="C2142_02670"
     CDS             12557..13963
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141892.1"
                     /locus_tag="C2142_RS02710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02670"
                     /product="lytic transglycosylase domain-containing protein"
                     /protein_id="WP_148640897.1"
                     /transl_table=11
                     /translation="MRAGIGNAGDGGAARTGRRLRLGKRVTGTAAAFTALAALTGSQVT
                     GLGLLPVAAADSATPVTDPLTPVSVSVSLPGTTFPGTAQPTLANKPGVPVDGGAATPLP
                     QPPTSLPGDPSAGPFRTGPALPETVFAAYRKAETALAQRSPGCHLPWQLLAAIGEVESG
                     QAGRGAVDAAGTTYRPILGPVLDGKGFAAIPDTDGGRHDGDRVWDRAVGPMQFIPSTWA
                     TWGVDANGDGQADPNNIFDAAEAAGRYLCAGGRDLADPAQLDRAVLGYNNSGEYLRTVR
                     NWMAHFGTGTATTTPDRPAPAGAVTAPTAPASSAAATPTTAPAPSPSATSPASPSATPT
                     PTSQPSPSATPTPTTSPSATPTAKPTTTPTGTPSTSPSTSPSATPTGTPTATPTDCPAP
                     TPTGTATPTATPSATASPSATATATPSATASPSATATATAPGCPVPTGTPSATATATLS
                     PSAAPSPSAH"
     gene            complement(14259..14843)
                     /locus_tag="C2142_RS02715"
                     /old_locus_tag="C2142_02675"
     CDS             complement(14259..14843)
                     /GO_process="GO:0006950 - response to stress [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014046887.1"
                     /locus_tag="C2142_RS02715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02675"
                     /product="TerD family protein"
                     /protein_id="WP_148640898.1"
                     /transl_table=11
                     /translation="MSVSLAKGQKLSLEKPGGGRLGLVRMGLGWRAAQKKGFFAKLLAS
                     QEIDLDASAVLFAEGKPVDVVFFQHLQSNDGSVRHSGDNLTGGAGDATDDESITVDLTR
                     VPAEVDQIVFTVNSFTGQTFQEVENAFCRLVDEQTGAELARYTLTGGGPYTAQIMAKVQ
                     RTAGGWQMAAIGQPASGRTFQDLMPELVKHL"
     gene            15007..15435
                     /locus_tag="C2142_RS02720"
                     /old_locus_tag="C2142_02680"
     CDS             15007..15435
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS02720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_02680"
                     /product="hypothetical protein"
                     /protein_id="WP_241002335.1"
                     /transl_table=11
                     /translation="MSDTLQAEAADPLRAEAAGAVLTGIGRLYRQRSAFDPVAVSIGHL
                     EDVGRFNIIGEKVTLWGTVRCAVEADMAEVEKRLVTLAEHTAQAYNCTAQVDYLQPVPA
                     SHSKPEWVAAALPTFRRVVGTDRVAWDHLTGTLEPTAG"
     gene            complement(15488..16135)
                     /locus_tag="C2142_RS02725"
                     /old_locus_tag="C2142_02685"
     CDS             complement(15488..16135)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133867.1"
                     /locus_tag="C2142_RS02725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02685"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_148640899.1"
                     /transl_table=11
                     /translation="MESRDWDERYAASELVWGGEPNRWVVREVAGLAPGRALDLAAGEG
                     RNGIWLAGRGWQVTGLDFSAVAVERAGRLTAQLPAEVAGRLTWRHGDARTFAAPPTGYD
                     LVLVAYLQLPAADRRAALRRAAAALAPGGTLLVVGHDTTNLTEGVGGPQDPRVLFTPED
                     VLADLAGTGLRTVRAERVRRPVAAEADHRAPAGEDGGRAEALDALVRLERTG"
     misc_feature    16232..16247
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.67"
                     /tool="antismash"
     gene            16415..18760
                     /locus_tag="C2142_RS02730"
                     /old_locus_tag="C2142_02690"
     CDS             16415..18760
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135938.1"
                     /locus_tag="C2142_RS02730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02690"
                     /product="glycosyl hydrolase family 18 protein"
                     /protein_id="WP_148640900.1"
                     /transl_table=11
                     /translation="MHDRVTPARPAERRAAAPRRRATALALAATLTTGSAALALSLNTA
                     SAASVNLLTNAGFETGTLAGWSCANGSVATTPVHGGGYSLSGAASASDTAQCQQTVAVQ
                     PNTQYILSGWVQGSYVYLGATGTGVNSQAWTPGATDWTQLSSTFTTGATTTSVTVFTHG
                     WYGTGTYRADDLTLTGPAGPTAGTSPTASNSPTASGSPTASTSPTASGSPTSSSSPTAS
                     GSPTVTTSPTATATATTPGTGPAGDGKVTTPTGVTVTKVTHNAVVLSWQPSTLTSGDGV
                     VAYKVYSGGQLVATSMGTSVAVSSLLPSTAYGFTVQGYSGSHGSAQSAKVSTTTAAAPA
                     ASPFRSAYFDQWGVYENAYHAKNVDTSGAAGKLDVITYAFANIHPTSHTCFQAVKASDS
                     ANESNPNAGDGAGDAYADYQADYTGAASVDGSGDVYEQPLKGNFNQLRQLKAKYPNLRF
                     TISIGGWTYSKYFSDAAATDASRKAFVSSCVDMFLKGNLPTGIAGDASGGQASAAGLFD
                     GVDLDWEYPGSAGGHTGNHYSPADKQNFTLLLKEFRTQLDALGNAQGKRFLLTAALPSG
                     QDKIARLETDQIGAYLDYADIMTYDMHGAWDATGPTNHQDPLHDSPNDPTTPITPGTRK
                     YNVDTTLTAYTTGLPEYGITGGFPANKLVLGIPFYWRGWTGVPAGNNFGLYRSATGPTP
                     AKPLSAEAGLAAWKELGATAANTHWDPVTETSWVYDGTNFWTGDTPQAIQARGAYAKSK
                     GLAGMFAFSLENDDASGTLLNAMNSSLH"
     gene            complement(18959..19519)
                     /gene="yidD"
                     /locus_tag="C2142_RS39165"
     CDS             complement(18959..19519)
                     /codon_start=1
                     /gene="yidD"
                     /inference="COORDINATES: protein motif:HMM:NF013932.4"
                     /locus_tag="C2142_RS39165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="membrane protein insertion efficiency factor
                     YidD"
                     /protein_id="WP_241002336.1"
                     /transl_table=11
                     /translation="MAHPPPHQPLSYPPPRRPEQAWWWLPEKERRRRKAQRWEWLAYKR
                     QNGKTKKKDRDWSDACDACDCCGDVADPCLIVLVPVMMAAGVRFALTGGRGRRRGQADP
                     AAPAPGGFAAGVLYGAVRYYRTEVSPKRPACCPYTPTCSTYAVQALHRHGAVRGARLTV
                     GRLLRCRPGVARRGNGVDPVPEH"
     gene            complement(19631..20404)
                     /locus_tag="C2142_RS02740"
                     /old_locus_tag="C2142_02700"
     CDS             complement(19631..20404)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049931.1"
                     /locus_tag="C2142_RS02740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02700"
                     /product="DUF4239 domain-containing protein"
                     /protein_id="WP_148640901.1"
                     /transl_table=11
                     /translation="MSEWLALAIAMSAACAVVVAVVLLRHRRASEDENTDETPDVIEYM
                     TMMIGVVYAIVLGLAIAGVWEARGAAQDDVLREAQSLHEVSERAQVYPVEFRDKVRADV
                     DAYVSYVVDVEWAYMREHGEISTRGTELLDKLRQDVATRTPAGDLEAQAYQPMMDRIST
                     ADDARNARGQNAGPTMPGVVWFGLIVGAVVTVGMVFALQIRRSTRELLLAGAFSALIAF
                     LLFLIWDFDDPFGRSVSVTTQPFTDLFPTLGGGQD"
ORIGIN
        1 gccgtcgtcc gggatgaccc agcggaacga ggcgacgtga cggtcggcca cgttgacatc
       61 cgatgaggtg ggcaagccac acgccgtcgc agtcgacagg acgccggcga ggacgtgtgg
      121 ccctcgtccg ggtcctatcc tgccagtccc cggagcaggc cctccagatc gcgctcgccg
      181 tcgctggtct gggcaccgtg agccagtccg ccgcggatca gacgctcggc cgcggggcga
      241 ccgacctggc ccgcccaggc gtcgtgctcc cgcaggagac cctcggccag gtcctcgggg
      301 acgatggcgc gcttggccgc cgcgatcaca ccctcgggca aggctgcgat gttgcgggcg
      361 aggcggtcaa cgatgtcgtc gagttcgtcg gcagggacgg cccggttcac ccatccgtag
      421 cgctctgcgg tttcggcgtc gtacagatcg gcacccagca ccgcctccag ggcgcgattg
      481 cggccgaccc ggccggcgag gtactgcgtg ccccctccac ccgggacgat gcccatgaga
      541 gcttcgatct ggccgatccc ggcgcgaccg atcgccgcga acgccatgtc tgcggccgtg
      601 acgaactctg cccctcctcc gcgcgccgtc ccggcgagct tgacgatggt tacctggggc
      661 tggtgccgaa gcagctcccc gagagcctgg aagacgttga cgccgtccgg aaggtcggcc
      721 gcgagcctgt cgaaggcgtc tggcgtgtcg acgagcgaca tgtcgacgtg ggctatgaag
      781 aactccggat cggcgctgtc gaacacgatc acccggaccg agtcgtcgtc cttcagcgcg
      841 gtcagcaggt gccggaggtc ggccatcagg gcgacgttca gcacgttgac gggcgggttg
      901 tcgagggtga cgcgggcgat gccgtcttcg cgactcaccc gcagggttgc gtaggcgtcg
      961 tggttcatgg aggtctccga tcggtacctg gtagacatct aggttcctga tgcatactca
     1021 cagtgcgacg gtgggtgacc ggccgtcaat aacgcacttt cggcatcgca aggatcgcgg
     1081 aggataccga catggccact tctgaaaccg gcgccgccgc cggcatcgac atcgtctacc
     1141 ggtccgactg ccccagccgc ccgatcctcg accagatcgc cgacaagtgg tcgatgatgg
     1201 tgatggcagt ccttgagaag cccacacggt tcaacgagat caagcgccgc cttgagggtg
     1261 tgacccagcg ggtcctgacc cagaccctgc gccgcctgga gcgcaacggg atggtcgtgc
     1321 gccgcgtgct gccaacctcg ccggtcgggg tcgagtactc cctcaccccg ctcggcgaat
     1381 ccctgcggga gccgttcggc cggctgtacg actggacggt cgacaacgcg gacgaaatcc
     1441 gggcgcacca aatggactat gaccaacgcg ttcagagctg agaaggcgtc cccgggaacc
     1501 ccctcgtcct cgtactgcaa cggtgcctgc gggcccagca gctcgaaagg gggccggacc
     1561 agctcgaaca ccagacctga taccgctgac cgtgcccgaa atccgccgac cggtcacccg
     1621 actcgcccgg cccgtccgcc gcagcatcga ccacgtcctg cgctggtccc gccggcgccg
     1681 ccaccgggcc cggatcagcc actaccgcga tgcgcgttac ggcgcgtcca cgagccgttg
     1741 gatggtgtcg gcgatccagc gttcgagctc ctcgctgtcg ccgaggtcgt cgcgcagcac
     1801 gcgcagccgc gcggagatcc cgaggacgaa gacgtcgact gcccgggcgc gggcgtgggc
     1861 ttcctcctcg gtcatcccgt agcgcagcag caactgccgc agcggctcca gtgattcccg
     1921 gtcgaggaac gtcgacaggg cttcggcggc ctcgccgcgt tcgcccgcgg cgcgcagcag
     1981 gacgaggagc gggtcctcgc cctccatacc ggtccaccgg tcgacgatgc cccgggccat
     2041 ccggtggccg agggagtgcc gcgggccgtc gaacctgcgg tcgagttcga ggcggacttc
     2101 ggtggcggcg acgaagagcc cgtccttgcc gccgaagtag cgggtgatga ggttgggcga
     2161 cacttctgcg gacgcggcga tggcgcggac cgtcgtgcgg gcgaatccgg tgcgcgcgaa
     2221 ctcgcgtcgt gcggcggtga ggatccgctc acgggtcagc gaggcgtcct tgagtcgtgg
     2281 cgtcgcggtt tccatgccgt cagggtatcg gcaccccgcc gcgatgtata cgcatgaaca
     2341 catgatgtgt atggttgtac acatgacgct gccgttcagc cccgtgaccg attccgctct
     2401 ggatgacctg caccgacgcc tcgccgcgac gcgcaggccg ctccttgccc gggcggccgg
     2461 gtgggaacgg ggcgcggacg cggacttcct cgcccgcctg ctcgattcct ggcgcgagcg
     2521 ctacgactgg cgggcccacg aggcccgtat cctcgacctg ccctgggaga ccgtcggctc
     2581 cggcgaccgc gccctccacc tcgtgcacca gcgcgccgcc gccgacgccc ctgtggtggt
     2641 tctgctgcac ggctggcccg actcggtgct ccgcttcgag cgggtgctcc ccctgctcga
     2701 agacctgaac gtggtcgtac ccgcccttcc gggcttcccg ttctcgcacg agtcggcacg
     2761 gcccgggatg acgaccactg cgatggcgtc gctggtgacc gacgcgaccc gggcgctcgg
     2821 atacgggcgg tacgtcgtct ccggcggcga tgtcggcgcg gacgtcgccg agcagctcgc
     2881 cgcgatgcac ccggaccggg tcgcggccct gcacctgacg aacgtctctc cactgcacgc
     2941 ggtcttcgcg gaccgctccg ccctgggcgc ggaggagctc gcctacctcg acaccgcggc
     3001 cgcgtggcag cgcgccgaag gggggtacat cgcacagcag tccaccaaac cgcacacgct
     3061 cgcgcccgcg ctggcggatt cgccggccgg actgggggcc tggatctgcg agaagctgtg
     3121 gagctggtcc cacatcccgt tcgaggagga ggtcctgctc acctggatca gcgtctactg
     3181 gttcacgaac acgatcggaa cgtcgttcac gccgtacgcc gaggtcgcgc cgccggtgcc
     3241 gtatgtggcg acgccgaccg tcctcagcgc cttctcgcac gacaccaagc ccgcaccccg
     3301 ctgcttcgcc tcccgcttcg tcaacgtccg ggagttcatc gagcacgaga acggaggcca
     3361 cttcgcggcc tgggagcagc cgctgcacta cgcggaggat ctccgccggg ccgtgggact
     3421 cgcggattgg tagcccgcgg acagcggccc gagtaccgcc tgcggttccg ggagaccggg
     3481 gcgcaccgtt gcagcatgag ggcggtccgg gccgacgtcg gccgaccgcg gtgcggcgta
     3541 cggcggggcc gggccctccg cctcccccga gcagcgggct gacgacccgt cggtcagtct
     3601 tcccgggcgt cgtcgtaggc ctcgcgggcg gccagcacct cgggcatgtt ctgctcggcc
     3661 cacgccttga tcgactgcat cagcgggagc aggcccgtcc cgagcggggt gagcgcgtag
     3721 tcgacccggg ccggtaccga gggcgtgacg gtccgggtga gcaggccgtc gcgttcgagg
     3781 gcccggaggg tctgggtgag catcttctcg ctcacgccgg ccaggcgccg gcgcaggtcg
     3841 ctgtagcgca ggggaccgtc ggcgagggcg ttgacgacca ggctgaccca cttgtcgccg
     3901 atccggtcga gcagttgccg ggccgggcac tcggcgaggt acgcgtcgaa gccggcgcgc
     3961 tcggccgcgc ggcgctgggc ggcggtcgtg gtggccatgg gctctcctcc ccgtacggta
     4021 cgcactttcc ggtgcgtgct tccccgtgga gagcaactct ccttagtttg ggagccgttc
     4081 gcaacctccg gttctgccga ccccaactcc gaggagcgcg ccatgcgtgc cgttgtcgtt
     4141 cgtaccttcg ccggccccga agccctggag ctggtggacg tgcccgtgcc cgaggccggc
     4201 cccggtcagg tccgggtgcg ggtggaggct gccggggtca acccggtgga cgcggtgacc
     4261 cgggccgggg tcctggcgca ggcggggctg atgccgccgc gcgaggtggt cgggatcggc
     4321 tgggacgtgg ccggcgtggt cgaccgggtc gggcccgggg tggccggatt cgcccccggc
     4381 gagcgggtga tcggcctgcg cgaccggctg gacgccccgc tgggctccta cgccgagtac
     4441 ctggtgctgg acgcctccgt gctggccccg gcaccggcgg gggtgccggc cgtggaggcg
     4501 gcgacgctgc cgctgaacgg gctgaccgcc gtccaggcac tggacctgct cggcctgccg
     4561 gccggtgcca ccctgctggt gaccggtgcg gcgggcgcgg tgggcggctt cgcggtcgag
     4621 ctggcggtgt tgcgcggact gcgggtcgtg gcactggcgg gcgaggagga cgaggcgctg
     4681 gtacgggagt tgggtgccga gtggttcgtc ccgcgcggca ccgccgatcc ggccgccgcc
     4741 gtccggtccc tcgtcccggg cggcgtggac ggcgcactgg acgcggccct gctgggtgtc
     4801 gtcgcactcg gcgccgtccg gaaccggggg gccttcgtcg ccgtctccgg gggcgcaccg
     4861 gtgggcctgc ggggcatccg ggtgaccaac gtctggatcg ccgccgacgg ccgcgcgctc
     4921 gccggcttgt ccgacctggc cgcccggcgc cgcctcaccc tgcgggtggc cgacgccctc
     4981 ccgctggaac aggccgccga ggcgcaccgg cggctcgacc ggggcggcct gcgcgggcgg
     5041 ctggtcctcg tcccctgagc ctgcgtgcca cccatgggac cggggtccac cacctcgacc
     5101 cgggccgccc gtacctcagg tgcaccgcca cccgagctgt tcacgcaccg gactagcggc
     5161 gcccggagcg ctgttggcgg agccaggcca cggcggcgac caggccgacg gcgccgcccg
     5221 cgcagagctt gacggcgccc ttggcaagca gccagccgag accggggaag gtccagccca
     5281 gccagtggaa gacggccagc atcaccgcca ccgcccccac cgccgccagc acggtgaccg
     5341 ccaccatggc cccggtggac agctcgcgct cctccgaagc cgtttccgcc gtttcgttcg
     5401 tgcccccaga atccatgaag ggcatcctaa cccggcgtca gcgaggtgcg tggtgggtat
     5461 cgccggtgtg ctcgccggtc tcgtggtcgg ggaagctgac ggccagggtg acgcggtact
     5521 cgaagacgtc gtcgcggtgg ccggggacgc gggcccaggc cagcgagtgc acctcggcct
     5581 cgggcgcctg ccggcaccag gcggcggcct cctccagcgc cctggccgcc gaacggccgg
     5641 tgcagaccac ggcggtgtag gcggcgaccg cgatgtcgcc gcagctgcgg ccggcccgcg
     5701 agaccgcccg gaccgcggcc gcggcatggg tgaggtcgcg ggcgaggtcg tcgaccacgc
     5761 ggggcggcgc cggcaggagg gccgggccct ccgccacggt ctccggcagg ttcgtgctca
     5821 ctgtctgggc ctccgtccgc ctggtcacgg gatccacctg gatcggggtc cgcctgaaaa
     5881 gggtccgcct ggtcacaggg tgcgcctggt cacgggccca aggatgccgg gccgccgttc
     5941 ctggcatgac cactttcacc ggaacatcac ccgtccgtgg agcggatggt gtagaagacg
     6001 acgccttcgg gcgcgccctg gtaagggacg gccgatgcat cgggccaggt caggccgctc
     6061 gccgacgggc gccgcccgga gcccgaccgc acctgcgcgc accaccgccg tgccccggac
     6121 cgcccgttcg gctcccggtc gcgcccggtt catgtcggct gccgggcgcc cgccgtgacg
     6181 gagtcgtaca actcccgttg caggaaacgg aaataccggc cgaggccgga cactaggatc
     6241 ctccccgagg cagtccgccg ccgtggcgga cgccgcccga gggggaaccc atgcagctca
     6301 agtcaccgct ccagtacggt cgtcggcacc tctggctgcc ggcgctggca ctcgcgggcg
     6361 ccgcgctggc cgggtgctcg tccggcagcg ggggcgggtc ggccgcgccc tccaccggca
     6421 gtgcggcgtc caccccggcc gccgcgccca ccactgcggc cccggtaccc acctctgccg
     6481 cgtccacccc ggccgcgccg gccaccactg cggcgccgac gggcaccgcc gccaagcgac
     6541 ccgccgacgc ctgcacgcta ctcaactccc cccaggtgat cgccgccgtc ggcaccggcg
     6601 gcccgttcac cggcacccac cccgacccgg cgagcgacgg cagcccggtc tggggctgca
     6661 cctggggctc ccgccagtcg tacgcgtcga tccgcgaggt gaagccgacc gtcctcgcca
     6721 ccgtcaaggc gaacccggac aaccagatca ccccggtgcc gggggcgggc caggaggcgg
     6781 tgctgacgca acgcaaggac ggcacccacc cggaggtgta cttcgtcgcc gacggccgca
     6841 cctactccgt cgaggtggtc aaggaccgcg gcccgggcga caacgtcaac gccccggcgg
     6901 aggcgttggc cgagagcggg ctggccctgg tgttcgccaa ggcgctcgcg ggctgagcgg
     6961 gccgaacgga cgggccaccg gagcggcccg gacggacgga ccggacggac ggaccggacg
     7021 gacggaccgg acggacggac ggaccggacg gaccggacgg acggaccgac cacgccggcc
     7081 gaccggacgg accggccttc gaacggcgcc gcggccccgg tggcctgggc cgttcgaagg
     7141 ccggccgggg acgccgggcg gcgcagcccg ttcccctcgg ggcgtgaacg gggccgggcg
     7201 ggggctgcgg gcggatgcgg gtgcggcgcg ggcgttcaca gaatgacgcc acggcgccgt
     7261 accccgtatt ccccctgacg gccaaggcgg atcgtatgag ccgattccac ccgtccccgt
     7321 cccggcccac gaggccgccg cgcacgaagc cccgggcccc gcagctccag ccccgcagcc
     7381 ccggccacaa agccccggcc cacgaagggc gcgcacagag cggcctccct gctctccggt
     7441 ctcgccctgc ccgcccccgc ggccggggcg ctggccaccg cgatacctgc gcgagccgac
     7501 aatccgacca tctcgggtac cagcatgcgc tatgcctggg acacggccga gccgggcctg
     7561 agccccgcgc aggtctcggc ctcggacttc ggccggcgct ggtccacggc cgtggacggc
     7621 gcggtgtacg cgcagccgct ggtggccggt tcgacggtgg cggtcgccac cgagaccaac
     7681 cacgtgtacg gcgtcggcgc ggccgacggc aaggtcctct ggcagcgcgc gctcgacacc
     7741 cccgtgccgt cgtccacggc ctgtctcccc gggtaccggg atcacctcaa cgcctgtgta
     7801 cgacaaggcg accggcacgg tctacttggt cacgaagtcc aacgagggcg gcgcgcactt
     7861 ctccgtgcac gccctggacg tcacctcggg cgccgagcgc agcggctggc cggtgccggt
     7921 ccagggcgac ccggtgaaca gcccgggcgt cccgttcaac gcggccacct ccgcccagcg
     7981 cgccggactg ctgctgctgg acggcgcggt gtacttcggc ttcgcctcgg actgcggggt
     8041 cggcacgtac gtcggccatg tcggcggcgt caacaccacg agccgcaagc tgacgctctg
     8101 gtccacggag tccggctcga actcgcagaa cggcggcgtc tggatgagcg gcggcggcct
     8161 ggtctcggac ggcgccgggc ggatcatcct ggccaccggc aacggcgcgg gaacgggctc
     8221 ctcgccggcc aaggggccgg ggaacaagcc ggggagccac ttcgcggact cggtggtgcg
     8281 cctgggcgtc aacagtgacg gcagcctcgc cccgaaggac ttcttcagcc cggccaacaa
     8341 ccgggacctc gaccacaacg acctcgacct cggctccggc ggcccggccg cgctcccgtc
     8401 cggcttcggc accacctcgc acccgcaccc gcacctgctg gtgcaggtcg gcaaggacgg
     8461 gcggatcttc ctgctggacc gcgacaacct gggcggcacg gtccagggcc cgaacggcac
     8521 cgacgccgtg gtgggcatga ccggcccgta caagggcgtc tggggccacc cgggcgtctg
     8581 gggcggcggc ggctacgtct acgtgatcga gaactacggt tcgctgcgcg cgctcaagta
     8641 ctcggtgaac ggctccggtg ctccgcagct gaccagcgcc gggacgagcg ccgagggctt
     8701 cggctacgcg tccggctcac cggtggtgac ctccaacggc acggccggcg ggtcggcgct
     8761 ggtctggctg atctactccg gtaccggtcc gggcggccag aacggcgaac tgcgcgtcta
     8821 cgacccggtt ccggtcaacg gcacgctcaa gatgcgccgc agcttcgccc tcggcacggt
     8881 gaccaggttc tccgtcccgg cgacggacgg agggcgggtg ttcgtcggca ccaaggacgg
     8941 gcacctgatc tcgttcggcc gcgcctgagg cagaccgccc gcatccaccg cgtccaccgc
     9001 gtgaccgcgg cccggccccg tccgtcaccc gttcgagcgc gtttgtccgc ggatcgcgcg
     9061 ggttggaacg gcggccgggc ccggcggctc gtagcgtcct gacccacggg gcccgatgcg
     9121 ccccgccccc aacccgacct cgtcccgagg gagaaccccg tgaagtgcac caccacaccc
     9181 cgccccgccc ccgccgtacc ggccgagcgc ccggccggcg ccgccaccgc ggcgaagccc
     9241 gcctggacca cccccgcggt ggagtgccac cgcgccggcg ccgaggtcac cgcctacgcc
     9301 gcgcggacca ctcggtgacc cagcccctga cccgcgaacg gttcgcggcc aggctgtacg
     9361 acctgcgcgg acggtactgg gacacccacc cgttccacct gcgcctgcac tccggtggct
     9421 gcacgccgcc ggagttgcgg cgttgggtcg ccaaccgctg gtactaccag ctctgcctga
     9481 cccgcaagaa cgccgccatc atcgccaact gcccgctgcc ggaggtccgt cgctcctggg
     9541 tggaacgcct cgcctaccag gacgggccca gcggcgacga gggcggtctg gccgactgac
     9601 tggtgctcgc cgaggccgtc ggcctggacc gcgccgaggt caccgacgag cggcacgtcg
     9661 cccgcggggt gcgcttcgcc gtcgacggct acctgcactt ctgccagacc aggccgtgga
     9721 ccgacggcgt ggcggcggcg ctcaccgaga tgttctcgcc cgaccacatg gcccagcggg
     9781 tcaccgcctg gcgcacccac tacgactgga tcgacccggc cgggtacgcc tacttcgagc
     9841 accgcatccc caccgcccgc aaggacagcg cccgcacgct cgaactggtc ctggaccact
     9901 gcgtcaccgc cacccagcag caggccgcgc tggacgcgct ggcgttcaag tgcgacgtcc
     9961 tgcgcgccat gctggacgcc gtcgactacg gcgccgaccg atgaccgccc ccgcccggac
    10021 cgaccaggtg cccggactgc ggcgcggcgt ccggatggtg cacgacccgg tccgcggccg
    10081 gggcgtgctg ctctaccccg agggcgtgct gctgctcaac gagaccgccg ccgcggtgct
    10141 gcgccactgc gacggccggc gcggcacgga cggcatcacc gccgaactca ccaccgagta
    10201 cgacggggtg gacccggacc aggtccgcgc gctgctcgcc gagctggccg ggcggcggct
    10261 gctcgccctg gacggcaccg gcgctccggc cgagccacgg caggccgccg gcctgcccgg
    10321 tgccccggtc cgcccgcccg cgccgctcgg actcgtcgcc gaactcaccc accgctgccc
    10381 gctgcagtgc acctactgcg ccaacccgat cgaactcacc tgccagcgcg acgagttgga
    10441 gacagagcag tggctgcgcc tgctcgacca ggcacgcggc ctgggcgtgc tccaggtcca
    10501 cctcaccggc ggcgaaccgc tgctccgccg cgacctggac cggatcatcg gccacgccca
    10561 ccacctgggc ctctacacca acctggtcac cagcggcctg ccgctggacg ccgagcgcac
    10621 cgcggagctc gccgacgcgg gcctggacca cgtccaactc tccgtgcagg acgccgacct
    10681 gcaccgcgcg gacgccgtgg ccggcctcgc cgcgcaccgg cgcaagctcg ccgcggccgc
    10741 gctgctgacc ggcgccggcc tgccgctcac cgtcaacgcc gtgctgcacc gcggcaacgt
    10801 ggccaggatc ggcgccctcg ccgacctggc ggtggagctg ggcgccgacc gggtcgagct
    10861 cgcacacacc cagttctacg gctgggcctg gcgcaaccgc gcacacctcg ccccgagcgg
    10921 ggaacaggtc cgccaggccg aacgggacgt ggccgccgcc cgggagcgtc acggcgaccg
    10981 catcgagatc gtgcacgtca ccgccgacca ccacggcgac accgccaaac cctgtatgga
    11041 cggctggggg cggcgccagc tggtggtggc ccccgacggc gacgtgctgc cctgcctggc
    11101 cgccgcccag ctgcccggcc tgccggtgcc gagcgccgtg accgacggcc tggccgcgat
    11161 ctggcacgac tcgcccgcgt tcaaccgcta ccgcggcacc gactggatgc cggagccgtg
    11221 ccgcagctgc gcgctgcgcg aggtggacca cggcggctgc cggtgccagg ccttccagtt
    11281 caccggcgac ccgggagcca ccgacccggc ctgtcacctc tccccgcacc accacctggt
    11341 cgccgggccc gcccccgccg gtgccccgcc ccccgtcccc cggagaatgc gctgaagatc
    11401 cggatcctcg gcaccgccgc cggcggcgga ctgccccagt ggaactgcgg ctgcgccggc
    11461 tgcaccaccg cccgccgcac cggcgccgcc cgcagccagg actgcctggc ggtcagcgcg
    11521 gacggcgccg cctggtacct ggtcaacgcc tcgcccgacc tgcgcggcca gctcctcgcc
    11581 gcccccgaac tcgccccctc tcccggcacc cgcgacaccc cgctgcgcgg cgtcctgctc
    11641 accagcggcg aactcgacca cacgctgggg ctgctgaccc tgcgggaggc cgccgagctg
    11701 accgtgcacg ccaccctccc ggtccgctac gccctccact cggccttccc ggccggcccg
    11761 ctgctcgcgc cgtacaccaa ggccggctgg cagaccctca ccccgggccg caccgtcgag
    11821 ctggccggcg ggctgcgcgc cgagccgctg gcgctcggcg gcaaacggcc ccgctacgcg
    11881 gccgacctgc ccggcgaggg ctgggagggc cggccggact gggtcaccgg cttccggttc
    11941 accgacgccg acggccgggc gagcgccgtg tacgcacccg ggctcgccga gtggacaccc
    12001 gcgatggacc gggcggtggc cggcgcggac gtggtcgtcc tggacggcac cttcagcacc
    12061 gacgacgaac tcgccgggca caccggcggg tcacgctcct cccgcggcat gggccacctg
    12121 gccgtcctgg actcgctccc ccacctggcc cgccaccccg gcccgcgcta cctctacacc
    12181 cacctcaaca acaccaaccc gctggcccac ccgggctcgc ccggcaccga ggccctcgcc
    12241 cgggcgctgg cggcggccgg cgcggccgtc gccgaggacg ggatgctgat cgagttctga
    12301 cggcgaggac gtgcacgcgc ggttcccggc ggactccacg ggcccgagca gtccggcccc
    12361 acccgccgtc aggccccctc accacctgcg cgttcatcca acggtggcgc ccaggacgcc
    12421 catcgctcac ccgggtcgcg tcaggtgatc gtgatactaa tcattcgggg gacgcgaact
    12481 gtcatgcact ggcaggcacg atggtgacag cccgtccgtt ccccgagggt ccgcacggtc
    12541 aggggagggg cacggtatga gggcagggat cggcaacgcc ggagacggcg gagcggctcg
    12601 gacggggcgt cggctgcgac tgggcaagcg cgtcaccggg acggcggcgg cgttcaccgc
    12661 gctggcggca ctgaccggtt cccaggtgac cggcctcggg ctcctgcccg tcgcggcggc
    12721 cgactcggcg acgcccgtca ccgacccgct cacccccgtc tccgtctccg tctcactgcc
    12781 cggcaccacg ttccccggca ccgcgcagcc gaccctggcc aacaagcccg gcgtccccgt
    12841 cgacggcggg gccgccaccc cgctgccgca gccgcccacc tccctgcccg gggacccctc
    12901 ggccggcccg ttccgcaccg ggcccgccct gccggagacc gtcttcgccg cctaccgcaa
    12961 ggccgaaacc gccctggccc agcgctcgcc cggctgccac ctgccgtggc agttgctggc
    13021 cgcgatcggc gaggtcgagt ccggccaggc cggccgcggc gccgtggacg ccgccgggac
    13081 gacctaccgg ccgatcctcg gcccggtgct cgacggcaag ggcttcgcgg cgatccccga
    13141 caccgacggc ggccgccacg acggtgaccg cgtctgggac cgggccgtcg gcccgatgca
    13201 gttcatcccc tccacctggg ccacctgggg cgtcgacgcc aacggcgacg gccaggccga
    13261 cccgaacaac atcttcgacg ccgccgaggc cgccggccgc tacctctgcg cgggcgggcg
    13321 cgacctcgcc gacccggcgc agctcgaccg ggccgtcctc ggctacaaca actcgggcga
    13381 gtacctgcgg accgtcagga actggatggc ccacttcggg accggtaccg cgaccaccac
    13441 cccggaccgt ccggcgccgg cgggcgcggt gaccgctccc acggcacccg cctcctccgc
    13501 ggcggccacc ccgaccaccg cgcccgcgcc gtccccctcg gccacctccc cggcctcgcc
    13561 gtccgcgacg ccgacgccca cctcacagcc gtccccgtcg gccaccccga ctccgacgac
    13621 gagcccgagc gccacgccca ccgcgaagcc gacgaccact cccaccggga ccccgagcac
    13681 cagcccgagc accagcccga gcgcgacccc gaccggcacg ccgaccgcga cgccgacgga
    13741 ctgcccggcc cccaccccca ccggcacggc cacgcccacg gccaccccga gcgcgacggc
    13801 gtccccgtcc gcgacggcga cggccacccc gagcgcgacg gcgtccccgt ccgcgacggc
    13861 gacggccacc gcccccggct gccccgtccc gaccggtacc ccctcggcca ccgcgaccgc
    13921 caccctctcc ccgtcggccg ccccctcgcc ctccgcccac tgagactgcc gggaccgccg
    13981 acggtggggg atccgggcct cccgggtccc ccgccgtcgg cgctcaccag ccgagaggcc
    14041 gccgtcgacc tcgccgtccc cgtggacgac gccggctgcg cggtcgcgcc ctgctcctga
    14101 acctcggcgc ccaggcggtc cgcggcggac gcggcacggg acgcccggac ggcccggcag
    14161 ccgaaccgtt cagcgcgcgg gcgacggacg cggggcccat ccggggggag atcggacggg
    14221 ccccgcgggt ccggagcggc tgagggtcgg ccgggctgtc agaggtgctt gaccagctcc
    14281 ggcatgaggt cctggaaggt gcgaccgctg gccggctgac cgatcgcggc catctgccag
    14341 ccgcccgccg tccgctgcac cttggccatg atctgcgcgg tgtacgggcc gccgccggtg
    14401 agcgtgtagc gggccagctc ggcgccggtc tgctcgtcga ccagccggca gaacgcgttc
    14461 tcgacctcct ggaaggtctg gccggtgaag gagttgacgg tgaagacgat ctggtcgacc
    14521 tcggccggca cccgggtgag gtcgacggtg atcgactcgt cgtcggtggc gtcgccggcg
    14581 ccgccggtca ggttgtcccc gctgtgccgc accgagccgt cgttgctctg caggtgctgg
    14641 aagaagacca cgtccaccgg cttgccctcg gcgaacagca ccgccgaggc gtccaggtcg
    14701 atctcctgcg aggccagcag cttggcgaag aagcccttct tctgggcggc gcgccagccg
    14761 aggcccatcc gcaccaggcc caaccgcccg ccgcccggct tctccaggct cagcttctga
    14821 cccttggcca gcgaaacgct catcgtgtcc tcctcgttcc tccgccgtgc gcgctctgaa
    14881 tctacagcac tgtagaaacg gcctgagccg acgtttcatc ggcacgcaac actcggtcct
    14941 agaagacccg gtaccccgtt cccaggatca acaccacatc atccgagcac agggaggagg
    15001 tacgccatga gtgacacgct ccaggccgaa gccgccgacc ccctccgggc cgaagccgcc
    15061 ggagcggtgc tcaccgggat cggccggctc taccggcagc gctccgcctt cgacccggtc
    15121 gccgtcagca tcgggcacct ggaggacgtc ggccggttca acatcatcgg cgagaaggtg
    15181 accctctggg gcaccgtccg ctgcgccgtc gaggccgaca tggccgaggt ggagaagcgc
    15241 ctggtcaccc tcgccgagca caccgcgcag gcctacaact gcacggctca ggtggactac
    15301 ctccagccgg tgcccgcgtc gcacagcaaa ccggagtggg tggccgccgc gctgcccacc
    15361 ttccgccggg tggtcggcac cgaccgcgtc gcctgggacc acctcacggg caccctggag
    15421 ccgaccgcgg gttgaccgcg cgggcccgca gcggggtcac gtacccaacg acggcggggt
    15481 gaccgcgtca gccggtccgc tccaaccgca ccagcgcgtc gagcgcctcg gcccggcccc
    15541 cgtcctcccc ggcgggggcc cggtggtcgg cctccgcggc gaccgggcgg cggacgcgct
    15601 cggcacggac ggtgcgcagg ccggtaccgg cgaggtcggc gaggacgtcc tccggggtga
    15661 acaggacgcg cgggtcctgc gggccgccga cgccctcggt gaggttggtg gtgtcatggc
    15721 cgaccaccag tagggtgccg ccgggggcga gcgcggcggc ggcgcggcgc agggcggccc
    15781 gtcggtcggc ggcggggagc tggagatagg cgaccaggac gaggtcgtag cccgtgggcg
    15841 gggcggcgaa ggtgcgcgcg tcgccgtggc gccaggtgag ccggccggcc acctccgcgg
    15901 gcagctgggc ggtgagccgt ccggcacgtt cgacggcgac ggcggagaag tcgaggccgg
    15961 tgacctgcca gccccgcccg gccagccaga tgccgttgcg cccctccccg gcggcgaggt
    16021 ccagggcacg gccgggggcg aggccggcga cctcgcggac cacccagcga ttgggttcac
    16081 ccccccagac cagctcgctc gccgcgtacc gctcgtccca gtcccggctc tccatcgccc
    16141 gtcctccgtt ccgcgggggc cactctccac gccaccgtac cggcgcggcg actttcggcc
    16201 atccagcggg ttgacgccct tgacggcgaa tattggtcca gtccaatctg tgatgtcgcc
    16261 gatgcgtaag gactcctggt cccgccgcgc cggcgcaccg taccgaagca cgtgctcacc
    16321 ccggtcgcgc gcccccacag cgctcggccc ggctcccctc ggcccgcccg ggcccatcgc
    16381 accgccggaa ccccactcat ccggaggaca ccgcatgcac gaccgagtca cgcccgcgcg
    16441 ccctgccgag cgccgggccg ccgcgccacg ccgccgggcc accgcactgg ccctggcggc
    16501 gacgctcacc accggcagcg ccgccctcgc cctgtcgctc aacacggcct cggccgcgtc
    16561 cgtcaacctg ctgaccaacg ccggcttcga gaccggcacc ctggccggct ggagctgcgc
    16621 caacgggtcg gtcgccacca ccccggtgca cggcggaggt tactcgctca gcggcgcggc
    16681 ctcggcctcc gacaccgcgc agtgccagca gacggtcgcc gtccagccga acacccagta
    16741 catcctctcc ggctgggtgc agggcagcta cgtctacctc ggcgcgaccg gcacgggcgt
    16801 caactcccag gcctggacgc ccggtgcgac cgactggacg cagctcagca gcaccttcac
    16861 caccggtgcg accaccacct cggtcacggt cttcacgcac ggctggtacg gcaccggcac
    16921 ctaccgcgcg gacgacctca ccctgaccgg gccggccggg ccgaccgccg gcaccagccc
    16981 gacggcctcc aacagcccca ccgcgtccgg cagtccgacg gcttcgacca gtccgaccgc
    17041 gtccggcagc ccgacctcgt ccagcagccc cacggcctcc ggcagtccca cggtgacgac
    17101 cagccccacc gcgacggcca ccgccaccac gccgggcacc ggcccggccg gggacggcaa
    17161 ggtcaccaca cccaccgggg tgaccgtcac caaggtcacc cacaacgccg tggtactcag
    17221 ctggcagccc tccaccctga ccagcggcga cggcgtggtc gcctacaagg tgtactcggg
    17281 cggccagctg gtggccacct cgatgggcac ctcggtggcc gtcagctcgc tgctgccgag
    17341 caccgcctac ggcttcaccg tccagggcta ctcgggcagt cacggctccg cccagtccgc
    17401 gaaggtctcc acgaccaccg cggccgcgcc cgccgcgagc ccgttccgct cggcctactt
    17461 cgaccagtgg ggcgtctacg agaacgccta ccacgcgaag aacgtcgaca ccagcggcgc
    17521 cgccggcaag ctggacgtca tcacctacgc cttcgccaac atccacccga cctcgcacac
    17581 ctgcttccag gcggtgaagg cctccgactc cgccaacgag tccaacccca acgcgggtga
    17641 cggcgcgggt gacgcctacg ccgactacca ggccgactac accggcgcgg ccagcgtgga
    17701 cggctccggc gacgtctacg agcagccgct caagggcaac ttcaaccagc tgcgccagct
    17761 gaaggccaag tacccgaacc tgcgcttcac catctcgatc ggcggctgga cgtactccaa
    17821 gtacttctcc gacgcggccg ccaccgacgc ctcccgcaag gccttcgtct cctcctgcgt
    17881 cgacatgttc ctcaagggga acctgccgac cggcatcgcc ggtgacgcct ccggcggcca
    17941 ggcctcggcg gccggcctct tcgacggcgt cgacctcgac tgggagtacc cgggctcggc
    18001 cggcggccac accgggaacc actactcccc cgccgacaag cagaacttca ccctgctgct
    18061 gaaggagttc cgcacccagc tggacgccct cggcaacgcc cagggcaagc ggttcctgct
    18121 gaccgcggca ctgcccagtg gccaggacaa gatcgcgcgg ctggagaccg accagatcgg
    18181 cgcctacctg gactacgccg acatcatgac ctacgacatg cacggcgcct gggacgccac
    18241 gggcccgacc aaccaccagg acccgctgca cgacagcccg aacgacccga ccacgccgat
    18301 caccccgggc acccgcaagt acaacgtgga caccacgctc accgcgtaca ccaccggcct
    18361 gcccgagtac gggatcacgg gcgggttccc ggcgaacaag ctggtgctgg gcatcccgtt
    18421 ctactggcgc ggctggacgg gcgtcccggc cggcaacaac ttcggcctgt accggagcgc
    18481 gaccggcccg acgccggcca agccgctcag cgccgaggcc gggctggcgg cctggaagga
    18541 gctgggcgcc accgccgcca acacccactg ggacccggtg accgagacct cgtgggtcta
    18601 cgacggcacc aacttctgga cgggcgacac cccgcaggcc atccaggcgc gcggcgccta
    18661 cgccaagagc aaggggctgg ccggaatgtt cgccttctcc ctggagaacg acgacgcctc
    18721 cggcaccctg ctcaacgcca tgaacagcag tttgcactga tgtagcgtca ggtcggtcgc
    18781 cgggctccgg cgcagcacgg ccgggcatcc ggtcgggctc cggcgcagca ccgcccggct
    18841 ccggcaaagc acagccgggc atccggtcag gcattgccgg gcgtcgccag gaatgacccg
    18901 ggggccgcgc ggatcacggt gatccgcgcg gcccccgggt cgcctccgcc gtccgccgtc
    18961 agtgctccgg caccgggtcg accccgttgc cgcggcgcgc cacgcccggt cggcagcgga
    19021 gcagccggcc gaccgtcagc cgggcgccgc gcaccgcacc gtgccggtgc agcgcctgga
    19081 cggcgtaggt cgaacaggtc ggcgtgtacg ggcagcaggc cggacgcttc ggactgacct
    19141 cggtccggta gtaccgcacc gcgccgtaga gcacgcccgc cgcgaagccg cccggggcgg
    19201 gcgccgccgg gtcggcctga ccgcggcgcc ggccgcgacc gccggtcagg gcgaaccgca
    19261 cgcccgcggc catcatcacc ggcaccagca cgatcagaca gggatcggcg acgtccccgc
    19321 agcagtcgca ggcgtcgcac gcatccgacc agtcgcggtc cttcttcttg gtcttgccgt
    19381 tctgccgctt gtacgccagc cactcccacc gctgtgcctt ccgccgccgt cgctccttct
    19441 cgggcagcca ccaccaggcc tgctcggggc ggcgcggcgg cggataggag agtggctgat
    19501 ggggcggcgg atgggccacg gctcacggtc ccttcggcag gcccgacggg accggccccc
    19561 gacggtccgg tcagattatc gaagacgggc catcgagggg cacggtcccg tgcaccctcc
    19621 gggagagcgg tcagtcctgg ccgcccccca gggtggggaa gagatcggtg aacggctggg
    19681 tggtcaccga gacgctccgg ccgaacgggt cgtcgaagtc ccagatcagg aagagcagga
    19741 aggcgatcag tgcgctgaac gcccccgcca gcagcaactc ccgcgtcgaa cgccggatct
    19801 gcagcgcgaa caccatgccg acggtcacca cggcaccgac gatcagaccg aaccagacca
    19861 cccccggcat ggtcggcccg gcattctggc cgcgggcgtt gcgggcgtcg tcggcggtgc
    19921 tgatccggtc catcatcggc tggtaggcct gggcctccag atcgccggcc ggggtgcggg
    19981 tggcgacgtc ctggcgcagc ttgtccagca gttcggtgcc ccgcgtggag atctcgccgt
    20041 gctcgcgcat gtacgcccac tcgacgtcga cgacgtacga gacgtaggcg tccacgtcgg
    20101 cgcggacctt gtcgcggaac tcgaccgggt acacctgggc gcgctcgctc acctcgtgca
    20161 gcgactgcgc ctcgcgcagc acgtcgtcct gggcggcgcc gcgcgcctcc cagacgccgg
    20221 cgatggcgag gccgagcacg atcgcgtaga ccacgccgat catcatcgtc atgtactcga
    20281 tgacatcggg tgtctcgtcg gtgttctcgt cctcgctggc ccggcggtgc ctcagcagca
    20341 ccaccgccac cacgacggcg caggctgccg acatggcgat ggccagcgcc aaccactcgg
    20401 acatgggaac tcccttcttc agcttgggtt ttccggtttc ttcggccggc tcggatgcgc
    20461 cggcctgcgg tcgccggctc gggttcgccg agcgggttcg ccggcttgcg cccaccggct
    20521 tgcgttcacg ggcttgcgtc caaccgcctt cggttccgct tccggcccgc gcgggtggtc
    20581 cgactcgcgc gggccggatc ggatggcccg gcccgggtgt tcccgcgcgt gcccggccgc
    20641 cgtcgtggga cgcggccgga caccgtggag cgggtgccgg ccaccgggcc cgagcgccgg
    20701 ggaacgtgcg cgccgtgggc gctcccggtg ggcgcgccgt ggtcaggagc ggccggagcc
    20761 gccacggccg gaccggccac gtgggcgcag ggccgccgca gccagtacgg cggggacggt
    20821 gaccagcagc atcgtcctgg tcggtgaact gccgtggtgg cgttccggcg cgggcgccgg
    20881 cggggccagc ggaagccgga ccggtttgac caccggcttc ggccggaccg ggctgggggc
    20941 cggcgcactg ggctcgaccg tcggtgccgg cggttccggc acgggcggcg ggggcgggac
    21001 gaccggctgc gcggtgggtc tcggcgtggg tgtcggcgtc ggccgggggg acgcgggcgg
    21061 cggggtgggc ctcggcgtcg gggtgggagc ggccggcgga accggtgcgg gggccggcgg
    21121 tggggtcggc gccggggtgg gtctgggcgt cggagtgggt gtcgacgtcg gcgtgggcgt
    21181 cggtttcgga gtgggtgtcg gcgtcggttt cggagtgggt gtcggggtgg gcgtcggcgt
    21241 agggctcggg cacgggtggc agggcttggg gtgcggatgc ggatgcggat gcggcttggg
    21301 gctgggcttg gggtggtgca acagcccgga gaggtcgacg gtcacgccga cctcgacgtc
    21361 gacgtcgacc tcgacgtcca cacccccctc gccga
//
