LOCUS       NZ_CP026498            22613 bp    DNA     linear   CON 22-MAY-2024
DEFINITION  Streptomyces sp. CB01881 chromosome.
ACCESSION   NZ_CP026498
VERSION     NZ_CP026498.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. CB01881
  ORGANISM  Streptomyces sp. CB01881
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     A 3-hydroxy-3-methylglutaryl-CoA synthase gene based probe for the
            discovery of the acyltransferase-less polyketide synthases
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11344947)
  AUTHORS   Liang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-JAN-2018) Xiangya International Academy of
            Translational Medicine, Tongzipo, Changsha, Hunan 410000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002953255.1-RS_2024_05_22
            Annotation Date                   :: 05/22/2024 02:39:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,978
            CDSs (total)                      :: 7,904
            Genes (coding)                    :: 7,565
            CDSs (with protein)               :: 7,565
            Genes (RNA)                       :: 74
            rRNAs                             :: 5 (5S)
            complete rRNAs                    :: 5 (5S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 339
            CDSs (without protein)            :: 339
            Pseudo Genes (ambiguous residues) :: 0 of 339
            Pseudo Genes (frameshifted)       :: 124 of 339
            Pseudo Genes (incomplete)         :: 251 of 339
            Pseudo Genes (internal stop)      :: 10 of 339
            Pseudo Genes (multiple problems)  :: 45 of 339
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:44:32
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 515485
            Orig. end                         :: 538098
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP026498.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22613
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22613
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22613
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12613](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12613
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(207..222)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 25.19"
                     /tool="antismash"
     misc_feature    939..953
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.58"
                     /tool="antismash"
     gene            complement(1254..2252)
                     /locus_tag="C2142_RS02475"
                     /old_locus_tag="C2142_02445"
     CDS             complement(1254..2252)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547015.1"
                     /locus_tag="C2142_RS02475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02445"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_241002328.1"
                     /transl_table=11
                     /translation="MGKQTAGDGAGPGRWGWARRVLVGLCAVGLTVPAALAVVRLGGWD
                     DGTSLAMPMVLLPYVAAGTLVALAVLLAVRSWWAAGVAGVLAVLQLCWLVPRFVPDGGS
                     VAADAPRLRVATSNTFKGQVDAAALVKLVREQRVDVLAVEEFWGAVPAALDRAGIAGLL
                     PYRQARPGRDTALYSRLPLAPLDASAPEAARAQVAADVAVGERTVRLTAVHTYYPLGDA
                     GRWSRDFAGLRAAATGATRNAVFLGDFNATLDHAPMRELLATGLTDTHAELGRGVSPTW
                     PEDNAGYPYLPPVIQIDHVLHGDALTAVSVAEHRLPGTDHRAVVAELAVTG"
     gene            complement(2547..3563)
                     /gene="galE"
                     /locus_tag="C2142_RS02480"
                     /old_locus_tag="C2142_02450"
     CDS             complement(2547..3563)
                     /EC_number="5.1.3.2"
                     /GO_function="GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (59-161). E-value:
                     7.1e-07. Score: 20.5. Matches aSDomain:
                     nrpspksdomains_C2142_RS02480_NAD_binding_4.1"
                     /codon_start=1
                     /gene="galE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571596.1"
                     /locus_tag="C2142_RS02480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02450"
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="WP_148640860.1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.6e-07,
                     bitscore: 29.6, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVLITGGAGYIGSTVASALLDQGITPVILDDLSKGRAEFVEGR
                     VFYQGDTADGALLDRIFAEHPDIDAALHCAARIVVPESVAKPLFYYRENVAKTVELLDS
                     LQRNGCTRVVFSSSASIYAPTPDARVDETCAVDANSPYARTKQMMEHVLQDWTRGDGAE
                     GIRVIALRYFNPVGADPQLRTGLQDLNPTHALGKLIEAHTNGTPFTVTGVDWATRDGSG
                     IRDYIHVQDLADAHVAALTRFDEVVKPAADDRYRVINVGTGEGTTVRELVTAFEEAVGA
                     KLDVREADPRPGDVIGCYAAVDTARELLGWTAQRTIAEGVTDALAWRAKWAARLASA"
     aSDomain        complement(3081..3386)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS02480_NAD_binding_4.1"
                     /evalue="7.10E-07"
                     /label="C2142_RS02480_NAD_binding_4.1"
                     /locus_tag="C2142_RS02480"
                     /protein_end="161"
                     /protein_start="59"
                     /score="20.5"
                     /tool="antismash"
                     /translation="RIFAEHPDIDAALHCAARIVVPESVAKPLFYYRENVAKTVELLDS
                     LQRNGCTRVVFSSSASIYAPTPDARVDETCAVDANSPYARTKQMMEHVLQDWTRGDG"
     CDS_motif       complement(3489..3551)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C2142_RS02480_0001"
                     /evalue="2.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="C2142_RS02480"
                     /protein_end="25"
                     /protein_start="4"
                     /score="13.8"
                     /tool="antismash"
                     /translation="LITGGAGYIGSTVASALLDQG"
     gene            complement(3708..4427)
                     /locus_tag="C2142_RS02485"
     CDS             complement(3708..4427)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS02485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_194235749.1"
                     /transl_table=11
                     /translation="MRIRPLAVALALAGAAVLGPAALPAVAHGDNVQLDVTGQEGGHVT
                     TVATFENDHEPVVEEFAGTLAATSADGRSAGPWRLVAVPGHPGSYTTREILPAGHWRIT
                     VDCAFPSLGHGERELDVEAAAIVDPVLPTPPTTTSGPTAPGPNSTTAPTTTTAPTTTTA
                     PTIAPTGTAAATPTVTPAPTPSAQSAGKPVTSAEIPQDEKSAGTSEAATWAAIGTAAAA
                     VVVVATGFWLRRRSRQA"
     assembly_gap    4515..4524
                     /estimated_length=10
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<4525..6701)
                     /locus_tag="C2142_RS02490"
                     /old_locus_tag="C2142_02455"
     CDS             complement(<4525..6701)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262356.1"
                     /locus_tag="C2142_RS02490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02455"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_148642135.1"
                     /transl_table=11
                     /translation="MAAAVVAGLVAGALGIQTALEPAAVRAGTAAAVGGSADRAEAGTA
                     GVVTEDGGPGETGTAEGATQAPAPKRDQKAAPLHEIPKDQPERGLVYTGLTLPTGDRCA
                     GSLEVTAGQLCSHGPDAPPKDIDIHKDVPPVAAAAAPVAALTPPADAQPPAAADLLKGG
                     APVLDAGQKALLGDAATPAAGAATPQQTPAAGGSALVCEGDGSTGNRIQVVYVHTPGND
                     RFAQYLPSFKKWAAEVDVIYNASAQETGGVRHVRFVTESDCTASVLNVQIADSEIQDFN
                     ASNRALAAQGFNRKDRKYMMFTDAKVYCGIGTFAGDERPGQDNLSNFGPSYGRTDSGCW
                     GGSTAAHELGHNLGAVSNSAPNSSKGGHCVDEWDLMCYSDAPYYPAMKTVCPDNASDNR
                     LDCHHDDYYNTNPAAGSYLATHWNVANNRFLIAGGGTGPNPTPTPTPTPTATPTRTPSP
                     TSTPSPTTPTPTATGSTTPSPTRTPSPTGTTTPGPTPTPTATPTGGNTAPAMTVSQITQ
                     NSAVLSWTAVPAAAGYDVLLNGQSVGTVRATVVGLVRLAPGTSYTVAVAVRDAAGTVSQ
                     PGRAATFSTLADGGRPQPGTRYTMVNGLTGQAADLWGSSLNDGTVAIAYQRTGYANQKW
                     TFEDAGSGAVRIKSVRSDKCLQLGGGPVAGQYLAQQPCSGASSQKWALTPSGGGFTLSA
                     EGSTLVLGVSNRWYYGGWLLELQKPNGQAYL"
     gene            complement(7468..7890)
                     /locus_tag="C2142_RS02495"
                     /old_locus_tag="C2142_02460"
     CDS             complement(7468..7890)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS02495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_02460"
                     /product="hypothetical protein"
                     /protein_id="WP_148640861.1"
                     /transl_table=11
                     /translation="MDCEEVMLTVRITAAERALLRELARGHGSDVSEVAADGLLDVIPA
                     LHDDTAALRLLRVLARPTACAVMLWLPAPVADLLPLLGDRIALAGGLRTCPASAALAAA
                     LRLWLAGDPARLAASLATMHAPVARRIAAPVLSVAA"
     gene            complement(7988..8767)
                     /locus_tag="C2142_RS02500"
                     /old_locus_tag="C2142_02465"
     CDS             complement(7988..8767)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF027645.4"
                     /locus_tag="C2142_RS02500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02465"
                     /product="sigma 54 modulation/S30EA ribosomal C-terminal
                     domain-containing protein"
                     /protein_id="WP_148640862.1"
                     /transl_table=11
                     /translation="MTRLRHRPAPDVRVEIRGELPREDAEYARVQALELFAALGPGVHG
                     ARVRLTRMCDRAVTRPVVAQAAVVLDGDGTVRVQLSGRTVREAVDLALGTLAARAARLR
                     EQGDIGLAAVYESAYRPQFTPRPLAERQIVRRKSVVLARRTPDEAARELLALDHGFHLF
                     VDALTGQDSLVHRRPVSGGLRLVRAHSTARLGGSALPLSESLHPAPRLDVAEAARRLWL
                     TCWPFVFHTDPDDGRGRVLYRRYDGHYGLIAPVTEAS"
     gene            9053..9508
                     /locus_tag="C2142_RS02505"
                     /old_locus_tag="C2142_02470"
     CDS             9053..9508
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS02505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_02470"
                     /product="hypothetical protein"
                     /protein_id="WP_148640863.1"
                     /transl_table=11
                     /translation="MTETIPLDQGDPRWVFPALTEAEAPAVEAALALAAGRMRRIATGL
                     GVRAGRAGAGLEYHRNEWIVAATITGFVETPDLLVVCSLGFPRRCGFDLSWGPPWRAGT
                     EVEVAGEVVDGWEEWFEQPVAAAEGFAAAADRLTGPVDAAVRRGHRA"
     misc_feature    complement(9054..9068)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(9987..10001)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.04"
                     /tool="antismash"
     gene            10001..12613
                     /locus_tag="C2142_RS41400"
                     /old_locus_tag="C2142_02475"
     CDS             10001..12613
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="C2142_RS41400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02475"
                     /product="cytochrome P450"
                     /protein_id="WP_148640864.1"
                     /sec_met_domain="p450 (E-value: 1.5e-71, bitscore: 240.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="T1TS (E-value: 1.1e-49, bitscore: 168.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLTIEPRRPIAPSRDAPRPGAPAAPPLAPGALPVLGHAPALLRD
                     PLGFLGSLSRHGGVVRIRLGPRTVCVVTDARLVHTLLVALAHDCPRGAVQDTLRTAFGD
                     GLLMSEGQAHRDRRRVVQPAFGQDRMAGYLAVMHQVTEERAARWRPGQVLDVAKEMNHL
                     ALEIVTRTLFDARLSEDATLAFHQALPDMVKGQIVQSLYPHPALARLPLPVNRRFDTAV
                     RVLNQVVDQAVDRGARPAGRPFGGEAQPGRNAAPTLPALLRAATDPATGRPLTEADVRS
                     EAITMFGAGTETVSTTLTWLIDELLRHPRVEALVLAELDEHLPAGTVPTPEALARLTYT
                     RSVTREVVRLHAPNAFLMRTASVPVELGRYRIPAGTELLYSLTALHRDPLLHPDPLRFH
                     PGRWREGDGSAGTGPRAFLPFGAGKHKCIGEAFAWAELTVAAAAILRRWRPTAVPGARA
                     REVVWTTVQAQGLRVRLAPREAPGAPAGPEARAGTAQADPVPTGTAQATVERPAAASAG
                     AAGAPRITAVPRPAPPAHPAPRPPATAGHRLPGELLTATTRHADWALHHGLLCPAELPR
                     YQAYALPGLIGHAYPRARGAELDLLVDVLGWFTILDDRFDGPPGHRPAQARAVVHPLLA
                     VLTGDVPAPAAGDSPLLHSWRELWQRQCDAMSPAWRERSAAEWRSCLETFLTESAHRAG
                     RTSPGLPETLRLRRHASCLYPFMNILERVHGADAPARLHADPTLHRLRAHTADAATLIN
                     DLYSLEREERQAAAAFNTVLTLQRVRGCTRTQAAAAVRARVARLREESDTLRRRLLLRH
                     PAGHWYLNGTRELVDGVQAWTSTSRRYVGDGPRVRDDQRLRDGQRLGDGHPLSDGLRG"
     gene            complement(12591..12722)
                     /locus_tag="C2142_RS39145"
     CDS             complement(12591..12722)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014146267.1"
                     /locus_tag="C2142_RS39145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6126 family protein"
                     /protein_id="WP_241002330.1"
                     /transl_table=11
                     /translation="MADGISDEKSRRKAMLIRAGIYIFATHLFAGFVILLFSLGGRR"
     misc_feature    12707..12721
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     gene            complement(12798..13130)
                     /locus_tag="C2142_RS02515"
                     /old_locus_tag="C2142_02480"
     CDS             complement(12798..13130)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139771.1"
                     /locus_tag="C2142_RS02515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02480"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_148640865.1"
                     /transl_table=11
                     /translation="MAVPLYQAKAEFFRTLGHPVRIRVLELLQDGPRPVRELLAEIEVE
                     PSNLSQQLAVLRRTQLVTATREGNTVVYALSTPDVAELLRAARRILTDLIADQGALLTE
                     LRAPGR"
     gene            complement(13388..13843)
                     /locus_tag="C2142_RS02520"
                     /old_locus_tag="C2142_02485"
     CDS             complement(13388..13843)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS02520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_02485"
                     /product="hypothetical protein"
                     /protein_id="WP_148640866.1"
                     /transl_table=11
                     /translation="MNRLTLLAAGVAGAATLLAIPAEAGAATATTTTTTVTCGASGLQA
                     GLSTKVCAEITGTGVAFYGQISLAGPPSPGSPELPTRQLLTGLSGQVVGGASLGSVSGG
                     TLFKASTVQVRGVSGTVTCGSTVHGSFSVADFPWNPAPVTVDVVVPC"
     misc_feature    13848..13862
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.55"
                     /tool="antismash"
     misc_feature    complement(13856..13870)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 15.78"
                     /tool="antismash"
     misc_feature    complement(13883..13893)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(13971..13986)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.89"
                     /tool="antismash"
     gene            14087..14314
                     /locus_tag="C2142_RS02525"
                     /old_locus_tag="C2142_02490"
     CDS             14087..14314
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C2142_RS02525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C2142_02490"
                     /product="hypothetical protein"
                     /protein_id="WP_148640867.1"
                     /transl_table=11
                     /translation="MKRLLRITAALAADRALAALVPGAILQLHVGAPDESPDHHCLDAE
                     ALPLIIDAVRARGYRILDLRELLDPARASG"
     gene            complement(14416..15570)
                     /locus_tag="C2142_RS02530"
                     /old_locus_tag="C2142_02495"
     CDS             complement(14416..15570)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014626931.1"
                     /locus_tag="C2142_RS02530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02495"
                     /product="glycoside hydrolase family 3 N-terminal
                     domain-containing protein"
                     /protein_id="WP_241002331.1"
                     /transl_table=11
                     /translation="MPSLRRTVRVAALILLLTAMTPAPVGTAHGTHRPPPTAERKSPVP
                     NEDSRRLAGRRIVYSYAGPTPPPALLRTISEGRAAGVILFGENITSPDQLRTAVGQLRQ
                     AAAEAPGALPLLLMTDQEGGKVRRLPGAPELSARRTGLAPDPVAEAARSGAGAGHNLAD
                     AGLNTNLAPVLDVFDTPDNFIDHFERSYGQDPSVVAGLGAAFLAAQQDLGVAATAKHFP
                     GLGAAARDQNTDEEPVTLPVPLAELRARGEEPYRAAIAAGVRLVMTSWAVYPALDPARP
                     AGLSPTVVQGELRDRLGFRGVTVTDALEAGALNLFGDTPARALAAAEAGMDLLLCSARD
                     VEQGDAAAVALADGLDSGRLDRQAFLDALHRVDTLRSGLAAGGR"
     gene            complement(15737..17218)
                     /locus_tag="C2142_RS02535"
                     /old_locus_tag="C2142_02500"
     CDS             complement(15737..17218)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (135-454). E-value:
                     6.3e-13. Score: 40.5. Matches aSDomain:
                     nrpspksdomains_C2142_RS02535_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836405.1"
                     /locus_tag="C2142_RS02535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02500"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_148640868.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 8.3e-11, bitscore:
                     40.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRSIEPAVDRSKPVGADFLQLDTADAPPGGLADWLAGRLRRAIA
                     DGRLPAGSRLPATRVLAAELRVSRGVVTDAYGRLAEEGQIAGRGRGGTVVVATPAPPPP
                     PAGPPAPAPAPFDAAPVPASFDALRAAPARINLSPGVPDLAAFPRAAWLRAERAVLDRL
                     SAHEFGYGDPRGTPALRRAVAHWLARNRGIRADPDEVLIVAGAAQALALLGQVLGQAGL
                     TEVAVEDPGSLGTRQHLGHWLTATPPVPVDADGIRVDALRATGAPAVLLTPAHQFPAGV
                     VLGGERRRELLRWAGEGGLVIEDDYDAEHRYDRAPVPALRGVLPEQVCYTGSVSKLLAP
                     ALRTGWLLVPPRHREAVLAAKRFADLGNAVLPQLVLARLMESGELERHLRLLRPRHRRR
                     RDAMIAAIGAHLPGAVVHGAAAGLHLMVTFPAGLDCTDTELATAALAHGVKVQPLSWHA
                     RLPHPPGLVLGYAAGAPGEITEGVAVLGGLLRRMG"
     aSDomain        complement(15857..16813)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS02535_Aminotran_1_2.1"
                     /evalue="6.30E-13"
                     /label="C2142_RS02535_Aminotran_1_2.1"
                     /locus_tag="C2142_RS02535"
                     /protein_end="454"
                     /protein_start="135"
                     /score="40.5"
                     /tool="antismash"
                     /translation="NLSPGVPDLAAFPRAAWLRAERAVLDRLSAHEFGYGDPRGTPALR
                     RAVAHWLARNRGIRADPDEVLIVAGAAQALALLGQVLGQAGLTEVAVEDPGSLGTRQHL
                     GHWLTATPPVPVDADGIRVDALRATGAPAVLLTPAHQFPAGVVLGGERRRELLRWAGEG
                     GLVIEDDYDAEHRYDRAPVPALRGVLPEQVCYTGSVSKLLAPALRTGWLLVPPRHREAV
                     LAAKRFADLGNAVLPQLVLARLMESGELERHLRLLRPRHRRRRDAMIAAIGAHLPGAVV
                     HGAAAGLHLMVTFPAGLDCTDTELATAALAHGVKVQPL"
     gene            17248..18117
                     /locus_tag="C2142_RS02540"
                     /old_locus_tag="C2142_02505"
     CDS             17248..18117
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (53-157). E-value: 6.3e-19. Score:
                     59.3. Matches aSDomain: nrpspksdomains_C2142_RS02540_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009720489.1"
                     /locus_tag="C2142_RS02540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02505"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_148640869.1"
                     /transl_table=11
                     /translation="MTTEKEFQETTARPRTAAPSERHGYVHGYSATEAQRLGDQADTLA
                     ELLHADTAYPTGSRVLEAGCGVGAQTLHLLAGSPGVRLTAADISADSLAEARARVAAHA
                     PGAKVTWHHGDLHELPFADGAFDHVFLCFVLEHLADPVTALAALRRVLRPGGTVTVIEG
                     DHGSAFFHPESAAARATVDHLVRLQADAGGDGLIGRRLHPLLTAAGFGDVAVRPRTVYA
                     DGSRPALGEGFTRRTFVAMVESVRDDAVAAGLTSAAAFDRGVVDLRRTAEEGGTFHYTF
                     FKAVAVNP"
     misc_feature    complement(17256..17270)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.91"
                     /tool="antismash"
     aSDomain        17407..17718
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C2142_RS02540_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="6.30E-19"
                     /label="C2142_RS02540_oMT.1"
                     /locus_tag="C2142_RS02540"
                     /protein_end="157"
                     /protein_start="53"
                     /score="59.3"
                     /tool="antismash"
                     /translation="YPTGSRVLEAGCGVGAQTLHLLAGSPGVRLTAADISADSLAEARA
                     RVAAHAPGAKVTWHHGDLHELPFADGAFDHVFLCFVLEHLADPVTALAALRRVLRPGGT
                     "
     gene            complement(18214..18717)
                     /locus_tag="C2142_RS02545"
                     /old_locus_tag="C2142_02510"
     CDS             complement(18214..18717)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014173638.1"
                     /locus_tag="C2142_RS02545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02510"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_148640870.1"
                     /transl_table=11
                     /translation="MADHVDRLVRQWGAERPDLDVSPMEVIGRLKRLTRLVEAELKRNF
                     AAHDLDTPSFDVLATLKRSGPPYRLTPTGLMESAMVTSGAISQRLDRLEARGLVTRTPS
                     GSDGRSRDVALTPEGHALVDRALPDHLTTERRILADLDPQQTEALIDALRTVLATLGEG
                     DEAG"
     misc_feature    complement(18689..18704)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.61"
                     /tool="antismash"
     misc_feature    18755..18770
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     misc_feature    18808..18823
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.25"
                     /tool="antismash"
     misc_feature    18810..18824
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            18827..19777
                     /locus_tag="C2142_RS02550"
                     /old_locus_tag="C2142_02515"
     CDS             18827..19777
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003543.1"
                     /locus_tag="C2142_RS02550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02515"
                     /product="EamA family transporter"
                     /protein_id="WP_162002391.1"
                     /transl_table=11
                     /translation="MLRNRLGIVLVTALAPAVWGSTYLVTTELLPPNRPLLAAVLRALP
                     AGLLLIAITRRLPKGSWWWRSLVLGALNIGAFMALLFIAAYRLPGGVAATVGAVQPLIA
                     AGLSAGLLGDRLSLRTLLSGIAGVIGVSLLVLRANAQLDALGVAAALGGAVVMATGVVL
                     SKRWTSPAPLLATTGWQLTAGGLMLVPVALLVEGAPPSHLTGANLLGYAYLGLIGAAVS
                     YALWFRGIRALPPTSVTFLGLLSPVVATALGWLVLGQDLSPVQGVGAVIVLGSLVAAQN
                     QRPRTTAPESPLPPAGQPASAEAAATQQPVPEPTR"
     gene            19864..20499
                     /locus_tag="C2142_RS02555"
                     /old_locus_tag="C2142_02520"
     CDS             19864..20499
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841191.1"
                     /locus_tag="C2142_RS02555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02520"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_148640871.1"
                     /transl_table=11
                     /translation="MRITVFGATGNVGSRVVAEALARGHQVTAVLRDPARPHSLPGAAT
                     IATGDARTAEDVTRLATGQDVVISATRPAPGSEGELATATKGLLAGMAGTGARLLAVGG
                     AGSLTLPGGGATVIDGPDFPPGWLPIALACNEQLALYRADTEVDWAYLSPAALLEPGVR
                     TGRYRLGRDELVVDADGTSAISMEDLAVALLDEAEQPAHHRTRFTAAY"
     gene            complement(20579..21115)
                     /locus_tag="C2142_RS02560"
                     /old_locus_tag="C2142_02525"
     CDS             complement(20579..21115)
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000413 - protein peptidyl-prolyl
                     isomerization [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020557119.1"
                     /locus_tag="C2142_RS02560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C2142_02525"
                     /product="peptidylprolyl isomerase"
                     /protein_id="WP_148640872.1"
                     /transl_table=11
                     /translation="MAESLIATLETTLGTIKVKLFPNHAPKTVRNFVELAQGEREWTHP
                     ETGQTSTDRLYDGTVFHRVIAGFMIQGGDPLGLGVGGPGYEFDDEIHPDLYFNRPYLLA
                     MANAGKRQGRGTNGSQFFITVGATPHLYGKHTIFGEVVEGAAVVDAIAKSDTDGGDRPV
                     EEVVLTKVTVERLGA"
     misc_feature    complement(21177..21195)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 16.93"
                     /tool="antismash"
     misc_feature    complement(21660..21674)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.93"
                     /tool="antismash"
ORIGIN
        1 catcgacccc cgactgatcg tccgccagga gggcatcaag gggtacctcg gcgagttccg
       61 ccgccgcctc ggcagcggcg aactcgggtc actgccggtg gtgctggccc tgatcgtgat
      121 ctgggccgtg ttcggcagtc tcaacagcag cttcctctcc gcccagaacc tctccaacct
      181 gtcccagcag atcgtcggca ccggcatgat cgcgatcggc gtggtcttcg tgctgctgct
      241 cggcgagatc gacctctcgg tcggctcggt cagcggactg tgcgcggcga tctacgccgt
      301 cctgagcgtc accgacggcg tcaaccagta cctcgcgctg ctcaccgccc tcgtcggcgg
      361 tgcggtggtc ggctgcatcc agggcgtctt cttcgccaag gtcggcgtcc ccgccttcgt
      421 cgtcaccctc gccggtaacc tcggctggaa cggcctgatg ctgcagatcc tcggcaccaa
      481 cggcacggtc aacctgcccg gcaacgactt cgtctccaag ctctacagca cgatctacgg
      541 gcagcagatc gccgcctacg gcacggcggc gatcggcgtc ctgctcttcg taggggcctc
      601 gttgttcgac gcgcgccgcc gccaggccgc gggcgtgccg tcccgtcccg tgtcggacat
      661 cgcgctgcgg accgtggtgc tggcgatcat cgcctttctc gccgcctaca cgctcaacca
      721 gtacaagggg ctcccgctgg cgctcctgat cttcctgatc ttcatcgtgg tgctggactt
      781 cgtgctgcgc cgcaccgcct acggccggca ggtcttcgcg ctcggcggca acatcgaggg
      841 cgcccggcgc gccggcatca acgtgtccgg gatccggatc agcgtgttca cgatctgctc
      901 caccatggcc gcggtcggcg gcctcttcct ggccgcgcag atccagtcgg ccagccagac
      961 ctccggcggc ggcaacctgc tgatgaacgc catcgccgcg gccgtcatcg gcggcaccag
     1021 cctgttcggc ggacgcggct cgacctggtc ggccctgctc ggcgcgctgg tgatcggctc
     1081 gatccagtcc gggatgaaca tccaaggcct cagcaacgcc atccagttca tggtcaccgg
     1141 cgcggtgctg ctggccgcgg tggtcatcga ctcgctggcc cgccgcaccc agaaggccgc
     1201 cggccgcgcc tgagcggcgg cgcgcccccg gcctcagggc tcagccggtc acgtcagccg
     1261 gtcaccgcga gttcggcgac cacggcgcgg tggtccgtcc ccggcagccg gtgctcggcg
     1321 acggacaccg ccgtcagcgc gtctccgtgc agcacgtggt cgatctggat caccggcggc
     1381 aggtaagggt agccggcgtt gtcctccggc caggtgggcg agaccccgcg gcccagttcg
     1441 gcgtgggtgt cggtgaggcc ggtggcgagc agctcgcgca tcggggcgtg gtcgagggtc
     1501 gcattgaagt cgcccaggaa gacggcgttg cgggtggcgc cggtggccgc cgcccgcagg
     1561 ccggcgaagt cccgggacca gcgcccggca tcgcccagcg ggtagtaggt gtgcacggct
     1621 gtcagccgga ccgtccgctc gccgaccgcg acgtcggcgg ccacctgggc acgggccgcc
     1681 tccggcgccg aggcgtccag cggggcgagc ggcagccggg agtagagcgc ggtgtcccgg
     1741 cccggccggg cctgccggta gggcagcagc ccggcgatcc cggcccggtc cagggcggcg
     1801 ggcactgcgc cccagaactc ctccaccgcg agcacgtcca cccgctgctc ccgcaccagc
     1861 ttcaccagcg cggcggcgtc gacctggccc ttgaaggtgt tgctggtagc caccctcagc
     1921 cgcggcgcgt cggccgccac cgagccgccg tccggaacga acctcggtac cagccagcag
     1981 agttggagta cggcgagtac tccggccacc ccggccgccc accacgagcg caccgcgagc
     2041 agcacggcca gcgccaccag ggtgcccgcc gcgacgtagg gcagcagcac catcggcatg
     2101 gccagcgagg tgccgtcgtc ccagccgccg agccggacca cggccagcgc ggccggcacc
     2161 gtcagcccga ccgcgcagag cccgaccagg acccgcctgg cccagcccca ccggcccggc
     2221 ccggccccgt cccccgccgt ctgcttcccc acccgccact cccgtcactc gactccgccg
     2281 ggaagacgcc gcctggcgag gtccggttcc cgcggcggga gcgggcgccc ttctggccgg
     2341 cccgccgggc cgtcagccgc cgcgcaccag ggggccggcc gggaaaccgg caggtcgaca
     2401 gtggtgagga cggacaggaa cccacccacc gaccgccgcc ggacacggcc ccgggcttcg
     2461 actacagctc tcccttcgac gccttgcgag acgagaacga gacgccgtga cggggtccgg
     2521 ggccggggcc ctaccgagct gccgggtcag gcggaggcga ggcgggcggc ccacttggcg
     2581 cgccaggcga gggcgtcggt gacgccctcg gcgatagtgc gctgcgccgt ccagccgagc
     2641 agctcgcggg cggtgtcgac ggcggcgtag cagccgatga cgtcgccggg gcgcgggtcg
     2701 gcctcgcgga cgtcgagctt ggcgccgacg gcctcctcga aggcggtgac cagctcgcgg
     2761 acggtggtgc cctcgccggt gccgacgttg atgacccggt agcggtcgtc ggcggcgggc
     2821 ttgaccacct cgtcgaagcg ggtgagggcg gcgacgtggg cgtccgcgag gtcctgcacg
     2881 tggatgtagt cgcggatgcc ggagccgtcg cgggtcgccc agtcgacgcc ggtgacggtg
     2941 aacggcgtgc cgttggtgtg ggcctcgatc agcttgccca gcgcgtgggt ggggttgagg
     3001 tcctggaggc cggtgcgcag ctgcgggtcg gcgccgaccg ggttgaagta ccgcagtgcg
     3061 atgacgcgga tcccctcggc gccgtcaccg cgggtccagt cctggaggac gtgctccatc
     3121 atctgcttgg tgcgcgcgta cgggctgttg gcgtcgaccg cgcaggtctc gtccacgcgg
     3181 gcgtccgggg tgggcgcgta gatggaggcg gagctgctga agacgacccg ggtgcagccg
     3241 ttgcgctgga gggagtccag cagttcgacg gtcttggcga cgttctcacg gtagtagaag
     3301 agcggcttgg cgaccgactc cggcacgacg atccgggcgg cgcagtgcag ggcggcgtcg
     3361 atgtcggggt gttccgcgaa gatccggtcc agcagcgcac cgtcggcggt gtcgccctgg
     3421 tagaacaccc ggccctcgac gaactccgcc cggcccttgg acaggtcgtc gaggatgacg
     3481 ggcgtgatgc cctggtcgag cagcgcggac gccacggtgc tgccgatgta acccgcgcca
     3541 ccggtgatca ggaccttctt catacgcggt tgctcccttg cctggtcggg cgcctccgtt
     3601 cggcggcccg ttgacagcac ggacgaccgg gcctgggcgg ccggttccgt cggccgtccg
     3661 atcgctcgcg caccgtcggc ttccgaccgg tcccgtgggg tcgcggatca ggcctggcgg
     3721 gaccggcggc gcagccagaa gccggtggcg accacgacga cggccgcggc ggcggtgccg
     3781 atggccgccc aggtggccgc ttcggaggtg ccggcgctct tctcgtcctg cgggatctcc
     3841 gccgaggtga cgggctttcc ggcgctctgg gcggagggcg tgggcgcggg ggtgaccgtc
     3901 ggcgtcgctg cggcggtgcc ggtcggcgcg atcgtgggcg cggtcgtggt cgtgggcgcg
     3961 gtcgtggtcg tgggcgcggt cgtggagttc ggcccgggcg cggtcggccc ggaggtggtc
     4021 gtcggcgggg tcggcagcac cgggtcgacg atggccgccg cctcgacgtc cagttcgcgc
     4081 tcgccgtggc cgagggaggg gaacgcgcag tcgacggtga tccgccagtg accggcgggc
     4141 aggatctccc gggtggtgta ggacccgggg tggccgggga cggcgaccag ccgccacggt
     4201 ccggccgagc ggccgtccgc ggaggtggcg gcgagcgtcc cggcgaactc ctcgacgacc
     4261 ggttcgtggt cgttctcgaa ggtggccacg gtggtgacgt ggccgccctc ctggccggtg
     4321 acgtcgagct ggacgttgtc cccgtgggca acggccggga gggcggcggg tccgaggacg
     4381 gccgccccgg cgagggcgag ggcgacggcg agcggtcgga tgcgcatgtc gggggttcct
     4441 cgtgggggga tggccggatg cggccgtcgc cggtgtgacg tggcgacggc cgcacccggg
     4501 tgggtggtgg gggcnnnnnn nnnntccagg taggcctggc cgttgggctt ctgcagttcc
     4561 agcagccaac cgccgtagta ccagcggttg ctgacaccga ggaccagggt cgagccctcg
     4621 gcgctcaggg tgaacccgcc acccgacggg gtgagcgccc acttctggga ggacgcgccg
     4681 gagcagggct gctgggcgag gtactggccg gccaccggac cgccgccgag ctggaggcac
     4741 ttgtccgaac ggacggactt gatccgcacc gcgccggatc cggcgtcctc gaaggtccac
     4801 ttctggttgg cgtagccggt gcgctggtag gcgatggcca cggtgccgtc gttgagcgag
     4861 ctgccccaga ggtcggcggc ctgcccggtg aggccgttca ccatggtgta ccgggtgccg
     4921 ggctgcggcc ggccgccgtc ggcgagggtg ctgaaggtgg ctgcgcggcc gggctgcgag
     4981 accgtgccgg cggcgtcacg cacggcgacg gccacggtgt acgaggtgcc gggggcgagc
     5041 cggaccaggc cgaccacggt ggcgcggacg gtgcccacgg actgcccgtt cagcagcacg
     5101 tcgtagccgg cggcagccgg gaccgcggtc cagctcagca cggccgagtt ctgggtgatc
     5161 tggctgaccg tcatggccgg ggcggtgttg ccgccggtgg gcgtcgcggt cggggtgggg
     5221 gtcgggcccg gcgtggtggt tccggtcggc gacggggtcc tggtcgggct cggggtggtg
     5281 ctcccggtgg ccgtcggggt cggggtggtg ggggacggcg tcgaggtcgg ggacggggtc
     5341 cgggtcggcg tggccgtcgg ggtcggggtg ggggtggggg tcgggttcgg accggtgccg
     5401 ccaccggcga tcaggaagcg gttgttggcg acgttccagt gcgtggccag gtaactgccg
     5461 gccgcgggat tggtgttgta gtagtcgtcg tggtggcagt cgagccggtt gtcactggcg
     5521 ttgtccgggc agaccgtctt catcgccggg tagtacgggg cgtccgagta gcacatgagg
     5581 tcccactcgt cgacgcagtg gccgcccttg ctcgaattgg gtgcgctgtt gctcaccgca
     5641 cccaggttgt ggccgagttc gtgcgccgcc gtggagccgc cccagcagcc ggagtcggtc
     5701 cgcccgtacg aggggccgaa gttgctcagg ttgtcctggc cgggccgctc gtcgcccgcg
     5761 aaggtgccga tgccgcagta caccttggcg tcggtgaaca tcatgtactt gcggtccttg
     5821 cggttgaacc cctgcgcggc gagcgcgcgg ttgctcgcgt tgaagtcctg gatctcggag
     5881 tccgcgatct gcacgttcaa caccgatgcg gtgcagtcgg attcggtgac gaagcgcacg
     5941 tgccggacgc cgccggtctc ctgggcgctg gcgttgtaga tgacgtcgac ctccgccgcc
     6001 cacttcttga acgacggcag gtactgggcg aagcggtcgt tgcccggggt gtggacgtac
     6061 accacctgga tccggttgcc ggtgctgccg tccccctcgc agaccagcgc ggacccgccg
     6121 gcggcggggg tctgctgggg cgttgcggct ccggccgccg gggtcgcagc gtcgccgagg
     6181 agggccttct ggcctgcgtc caggaccggg gcaccgccct tcagcaggtc ggccgcggcg
     6241 ggcggctggg cgtcggcggg cggcgtcagc gccgccaccg gggcggcggc cgcggcgacc
     6301 ggcgggacgt ccttgtggat gtcgatgtcc ttgggcggcg cgtccggacc gtggctgcac
     6361 agctggcccg cggtgacctc cagcgagccg gcgcagcggt cgcccgtcgg cagcgtcaga
     6421 cctgtgtaga cgagaccgcg ttccggctgg tccttgggta tctcgtgcag cggcgcggcc
     6481 ttctggtccc gcttcggagc gggtgcctgc gtggcgccct cggcggtgcc ggtctcaccc
     6541 gggccgccgt cctcggtgac gactccggcc gtgcccgcct ccgcccggtc ggccgatccg
     6601 ccaaccgccg ctgcggtgcc ggcccggacg gcggccggct ccaacgcggt ctggatgccc
     6661 agtgcgcccg ccaccagtcc ggccactacc gccgccgcca taagcgccgt ccggcgcccc
     6721 gacctcttgc gccgcctgcg gcgggtctcc gtactccggt gtcccatcgc actctctcct
     6781 gtcctcggtg tgacggtccg ttcgccatgt gacgtggcgt ccggaccttc cgacaccctg
     6841 gagaccgggg aggacgggag gggataacag aaacatcttt cgaaattcga tcgggtggat
     6901 cggcgtcgtg ccacgacggg gtgtgcggcc gggtgtgcgg ccgggtgcgc gcggtgggcg
     6961 gagggggtgc gcagcgggtc gcgcaaaggc gagcggcggg gcgcgggcat gggcgcgcga
     7021 gcgggcatac gggcgggcgc gcgagcgggc gcgcggcagt gccggggagc acgctcgggg
     7081 ggtacgcgct ccccggcagg ggtggtggcg gccacccggc cgggctgccc gggggtccgg
     7141 gttccggctg ccgtgaccgg aatgctagac ccgccgggtg gccgtggcca gagctctgac
     7201 cagccgattt tccgccccgg acatgccact gcgacccacc gggcacagcc gcagcgtctc
     7261 acctccgagc ggacatcagc tccgagcgga catcagctct gagcggacgt cacctccggc
     7321 tggatgccac ctccgaccgg acgtcatctt cggccggacc tcaccccggc aaccgcgacg
     7381 gcgcggtcgg cacgacgacg cggggcggcc gccgtccgat cagaccgccg tccgatcaga
     7441 ccgccgcctg atcaggccgc cgtccggtca ggccgccacg ctcagcacgg gggcggcgat
     7501 ccggcgggcg accggggcgt gcatggtcgc gagggaggcg gccagccggg ccgggtcgcc
     7561 ggccagccag agccgcagcg cggcggcgag cgcggcgctg gcggggcagg tccgcagccc
     7621 gccggcgagg gcgatccggt cgccgagcag cgggagcagg tccgcgacgg gcgccggcag
     7681 ccagagcatg acggcgcagg ctgtgggacg ggcgaggacg cgcagcagcc gcagcgccgc
     7741 ggtgtcgtcg tgcagggccg ggatgacgtc gagcagcccg tccgccgcca cctccgagac
     7801 gtcgctgccg tggccgcgcg ccagttcgcg cagcagggcc cgctcggccg cggtgatccg
     7861 gacggtcagc atgacttctt cgcagtccat ggtcctggtc ccgccttccg cttgaggggt
     7921 gtgcccgtcg gtgggtcacg cgcgtgctgg tccccggcgc cgtggggcgc cgaaagggtt
     7981 ctgcccgtca ggaggcctcc gtcaccggcg caatcaggcc gtaatggccg tcgtaacggc
     8041 ggtagagcac ccggccgcgg ccgtcgtccg gatcggtgtg gaagacgaac ggccagcagg
     8101 tgagccagag ccgccgggcg gcctcggcca cgtcgaggcg gggcgcgggg tgcaggctct
     8161 cggacagcgg gagggcggat ccgccgagcc gcgcggtcga gtgggcgcgg accagccgca
     8221 ggccaccgct caccggccgg cggtggacca ggctgtcctg tccggtgagt gcgtccacga
     8281 agaggtggaa gccgtggtcc agggcgagca gctcgcgggc cgcctcgtcg ggggtgcggc
     8341 gggcgaggac gaccgacttg cgccggacga tctgccgttc ggccagcggg cgcggggtga
     8401 actgcggccg gtaggcgctc tcgtacaccg cggccagccc gatgtccccc tgctcgcgca
     8461 gccgggcggc ccgggcggcg agcgtgccga gcgcgaggtc caccgcctcg cggacggtcc
     8521 tgccggacag ttggacccgg accgtaccgt cgccgtccag cacgaccgcg gcctgcgcca
     8581 cgaccggccg ggtcaccgcc cggtcgcaca tccgggtgag ccggaccctg gccccgtgca
     8641 ctcccgggcc gagcgccgcg aacagttcca gcgcctgcac ccgcgcgtac tcggcgtcct
     8701 cgcggggcag ctcgccgcgt atctccaccc gtacgtcggg ggcgggccgg tggcgcagac
     8761 gggtcatcag ggtcctcctc ggttccggac catgccgggg tctccggaac gtgccggacg
     8821 gttccggacc atgctggacc gtcggaggcc ctccggccga gggcctaaag accctgcctg
     8881 tgaggcaacg gcgaccggcc ccgcccggcc cgtccgccca ggtcagaccc tgaaccggga
     8941 cgcggcggcg cccgggggcg tgagcgccgt ggtccgcgcc gctccgccgt accggtcaca
     9001 gcgcctgacg gccggttgcg gacgtgcacc gttccgggcc agactcccgt tcgtgaccga
     9061 gacgatcccc ctggaccagg gcgacccgcg ctgggtcttc ccggccctca ccgaggccga
     9121 ggcccccgcc gtcgaggccg cactcgccct cgccgccggc cggatgcgcc ggattgccac
     9181 cggactcggc gtccgggcgg gccgggccgg ggccggcctg gagtatcacc ggaacgagtg
     9241 gatcgtcgcc gccaccatca ccggcttcgt cgagacaccg gacctgctcg tggtctgctc
     9301 actcggcttc ccgcgccgct gcgggttcga cctgagctgg gggccgccct ggcgggcggg
     9361 gaccgaggtc gaggtggcgg gcgaggtggt ggacggctgg gaggagtggt tcgagcaacc
     9421 cgtggcggcc gccgaggggt tcgccgcggc ggccgaccgg ctgaccggcc cggtggacgc
     9481 cgcggtccgg cgcggccacc gggcctgacg gtggggcccg ctcgatctgc cggtggggcc
     9541 gccgggcctg ccggtcgggc cacggggcct gccggtgggg ccgccagctc tgccggtgga
     9601 gtcgccgggc ctgccggtgg tgccgccagc tctgccggtg gagtcgccgg gcctgccggt
     9661 ggagtcgccg gatctgccgg tggagtcgcc gggcctgctg gtggagtcgc cggatctgcc
     9721 gacggggtgt caccgggccg tgccgctacc acatcgcccg cggtcaacgc gcccaccgcg
     9781 cgcgccgcgc ccgggcggga gcggcacgat ccaccgatgg ggtgatcccc ccgcgtacgg
     9841 cgcaacgctc gcgggaccgg cgcgttttct atgacgtgcg ccctccgtct gtggcgcgcg
     9901 cgcgggggtc tgcgctggcc ggagcccccg gatcccgcct gtcgcggcgg cggctccggc
     9961 gggcccgccg cgccggtcca actggttgag agagaatgtc atgcccctga cgatcgagcc
    10021 ccgtagaccg atcgccccct ccagggacgc cccccggccg ggggcgccgg ccgctccccc
    10081 gctcgcgccg ggcgcactcc ccgtcctcgg ccacgccccc gccctgctcc gcgacccgct
    10141 cggcttcctc ggctcgctct cccgccacgg cggagtggtg cggatccggc tcggtccgcg
    10201 caccgtctgc gtggtcaccg acgcccgcct ggtccacacc ctgctggtgg cactcgccca
    10261 cgactgcccg cgcggcgccg tccaggacac cctcaggacc gccttcggcg acggcctcct
    10321 gatgtccgag ggacaggcgc accgcgaccg ccgccgggtc gtccagcccg ccttcggcca
    10381 ggaccggatg gccggctacc tcgcggtgat gcaccaggtc acggaggagc gcgcggcacg
    10441 ctggcggccc ggccaggtcc tcgacgtggc caaggagatg aaccacctcg cgctggagat
    10501 cgtcacccga acgctgttcg acgcgcggct gagcgaggac gcgacgctcg ccttccacca
    10561 ggcgctgccc gacatggtga agggccagat cgtccagtcc ctctacccgc accccgccct
    10621 cgcccggctg ccgctgccgg tcaaccggcg gttcgacacc gccgtccggg tgctcaacca
    10681 ggtggtcgac caggccgtcg accgcggcgc ccggccggcc ggccgcccct tcggcggcga
    10741 ggcgcagccc ggccgcaacg cggcccccac gctgcccgcc ctgctgcgcg ccgcaaccga
    10801 ccccgccacc ggccgcccgc tcaccgaggc ggacgtgcgc tccgaggcga tcaccatgtt
    10861 cggcgcgggc accgagaccg tctccaccac gctcacctgg ctgatcgacg aactgctgcg
    10921 gcacccgcgg gtggaggccc tcgtcctcgc cgagctggac gagcacctcc cggcgggcac
    10981 cgtccccacc ccggaggcgc tcgcccggct cacgtacacg cgcagcgtca cccgggaggt
    11041 ggtccggctg cacgcgccga acgccttcct gatgcgcacc gcgagcgtgc cggtcgagct
    11101 cggccggtac cggatcccgg ccggtaccga gctgctctac agcctcaccg cgctgcaccg
    11161 cgacccgctg ctccacccgg acccgctgcg cttccacccc ggccgctggc gcgagggcga
    11221 cggctcggcg ggcaccgggc cgcgggcgtt cctgccgttc ggggcgggca agcacaagtg
    11281 catcggcgag gcgttcgcct gggcggagct gaccgtggcc gccgccgcga tcctgcgccg
    11341 ctggcggccg acggcggtgc cgggcgcccg ggcccgcgag gtcgtctgga ccaccgtcca
    11401 ggcccagggc ctgcgcgtcc ggctcgcccc gcgcgaggcc cccggtgcac cggcaggacc
    11461 ggaggcacga gcgggcaccg cgcaggcgga ccccgtacca accggcaccg cccaggccac
    11521 cgtcgaacga cctgccgccg cttccgcagg tgccgccggc gccccacgga tcaccgccgt
    11581 cccgcggccg gccccgcccg cgcacccggc gccgcgccca cccgccacgg ccggccaccg
    11641 cctccccggc gagctgctca ccgccaccac ccggcacgcc gactgggcgc tccaccacgg
    11701 cctgctctgc cccgccgagc tgccgcgcta ccaggcctac gcgctccccg ggttgatcgg
    11761 ccacgcctac ccccgggcgc gcggcgccga gctcgacctg ctggtcgacg tcctcggctg
    11821 gttcaccatc ctcgacgacc gcttcgacgg cccgcccggc caccgccctg cgcaggcccg
    11881 cgccgtcgtc cacccgctgc tcgccgtcct gacgggcgac gttcccgctc cggcagcggg
    11941 cgactccccg ttgctgcact cctggcggga actgtggcag cgccagtgcg acgcgatgtc
    12001 gcccgcctgg cgcgaacgga gcgccgccga gtggcggtcc tgcctggaga ccttcctcac
    12061 cgagtccgcg caccgggccg gacgcacctc ccccggcctg cccgagaccc tgcgtctgcg
    12121 tcgtcacgcc agctgcctct acccgttcat gaacatactg gagcgcgtcc acggcgccga
    12181 cgcacccgcc cggctgcacg ccgaccccac gctgcaccgg ctgcgcgcgc acaccgccga
    12241 cgccgcgacg ctcatcaacg acctctactc gctggaacgg gaggagcggc aggccgcggc
    12301 cgccttcaac accgtgctga ccctgcaacg cgtccgcggc tgcacccgca cccaggccgc
    12361 ggctgcggtc cgcgcccggg tcgcgcgcct gagggaggag agcgacacgc tccggcggcg
    12421 cctgctgctc cgccacccgg ccggccactg gtacctgaac ggcacccggg agctggtcga
    12481 cggcgtacag gcctggacca gcacctcccg ccgctacgtc ggtgacggcc cccgcgtcag
    12541 ggacgatcag cgcctcaggg acggtcagcg cctcggtgac ggtcaccccc tcagcgacgg
    12601 cctccgaggc tgaacagcag gatcacgaac ccggcgaaga ggtgcgtggc gaagatgtag
    12661 atgcccgcgc ggatcagcat ggccttgcgc ctgctcttct cgtcgctgat gccgtcggcc
    12721 atggccgggt tctccttcgg gtcgggcggt cgtcgcgcac ggtccgggcg ggcgtcggca
    12781 cgacgcccgc ccggtgctca tcgaccgggc gcgcggagct cggtgagcag cgcgccctgg
    12841 tcggcgatca ggtcggtgag gatgcgccgg gcggcgcgca gcagttcggc gacgtccggc
    12901 gtgctgagcg catagaccac ggtgttgccc tcgcgggtgg ccgtgaccag ctgggtccgg
    12961 cgcagtaccg cgagctgctg ggagaggttg gacggctcga cctcgatctc ggccagcagc
    13021 tcgcgcaccg gccgcggccc gtcctgcagc agctccagca cgcggatgcg gaccgggtgc
    13081 ccgagggtgc ggaagaactc cgccttggcc tggtacagcg ggaccgccat cgtccgttct
    13141 ctccctgctg ttcgctggtg cccgggggcg cccgatcggc gggcagtccg gcggcccggt
    13201 gcggccggga agcatcatcc cttgcggatg aagaattctt caagtcgtca tcgcgcccgg
    13261 ccgccgacca ccgccgccac cccgctgcca ccccctgccg acttccctct ccggccccct
    13321 cccccatgaa cgaacagggc ccgggagtcc gccaaccccc gggccctgct gcactaccgg
    13381 cgcgtcatca acacggcacc acgacgtcga cggtcaccgg agccgggttc cacgggaagt
    13441 cggccacgct gaagctgccg tgcacggtcg agccgcacgt caccgtgccg ctgacgcccc
    13501 gcacctgcac cgtgctggcc ttgaacaacg tgcccccgct caccgagccg agcgaggcgc
    13561 cgcccaccac ctgaccggag aggccggtca gcagctgcct ggtcggcagc tccgggctgc
    13621 ccgggctcgg cggaccggcc agggagatct ggccgtagaa cgcaacaccg gtgccggtga
    13681 tctcggcgca caccttggtc gacagaccgg cctgcaggcc ggaggcgccg caggtgacgg
    13741 tggtggtcgt ggtcgtggcg gtcgccgcgc cggcctcggc ggggatggcc aggagggtcg
    13801 ccgccccggc gacgccggcc gcgagcagag tgagtcggtt catccgcttc tccgtttcac
    13861 aaagtcatac agttctgcgc atgtgacatt tcacatgtgc catgccgtaa ccctggcaca
    13921 tgattcgaat gcccaccggc gattgggcca tcgacccatc ggacagaccg gaaaacagcc
    13981 tttcgatggc gcgatcttgg ctcttgaccg caggtgaatg ccgccgaacg gcaccgaggt
    14041 ggcccgtgcc cgtgccctcg acccggcgtg gggtgttgga cggggtgtga agcgtctcct
    14101 ccggatcacc gccgccctgg ccgccgaccg cgccctcgcc gccctcgttc ccggagcgat
    14161 cctccagctc cacgtcggcg cgcccgacga gagccccgac caccactgcc tggacgccga
    14221 ggcgctgccg ctgatcatcg acgccgtccg tgcccgcggc taccgcatcc tcgacctgcg
    14281 cgagctgctc gaccccgcac gggcgagcgg gtgatcaggc gaggacgtcg gccgtcatgg
    14341 tgggggacga tcccggccct cccccgccgc tgctccccgg acggcccccg gcaggccccg
    14401 gcaggccccg gcaggctacc ggccgcccgc ggcaagaccg gagcgcaggg tgtcgacccg
    14461 gtggagggcg tcgaggaagg cctggcggtc caggcggccg ctgtccaggc cgtcggccag
    14521 ggcgacggcg gcggcatcgc cctgctcgac gtcgcgggcc gagcagagca ggaggtccat
    14581 gcccgcctcg gccgcggcga gggcccgggc gggggtgtcc ccgaacaggt tcagggcgcc
    14641 ggcttcgagt gcgtcggtga cggtgacgcc ccggaagccg aggcggtcgc ggagttcgcc
    14701 ctggacgacg gtgggcgaca ggccggccgg gcgggccggg tcgagggcgg ggtagaccgc
    14761 ccaggaggtc atgaccaggc ggacgccggc cgcgatggcg gcgcggtagg gctcctcgcc
    14821 gcgggcgcgg agttcggcga gggggacggg cagggtgacg ggctcctcgt cggtgttctg
    14881 gtcgcgcgcg gcggcgccga ggcccgggaa gtgcttggcg gtggccgcga cgccgaggtc
    14941 ctgctgcgcg gccaggaagg cggcgcccaa cccggccacc acggagggat cctggccgta
    15001 ggagcgctcg aagtggtcga tgaagttgtc gggggtgtcg aagacgtcga ggacgggcgc
    15061 gaggttggtg ttcagaccgg cgtcggcgag gttgtggccg gcgccggcgc ccgagcgggc
    15121 ggcctcggcg accgggtcgg gcgccagccc ggtgcggcgg gcggagagtt cgggagcacc
    15181 gggcagccgg cggaccttgc cgccctcctg gtcggtcatc agcagcagcg ggagggcgcc
    15241 cggggcctcg gcggcggcct ggcgcagctg cccgacggcc gtgcggagtt ggtcgggcga
    15301 ggtgatgttc tcgccgaaca ggatgacgcc tgccgcccgg ccctcgctga tcgtccgcag
    15361 cagggccggc ggcggggtcg gcccggcgta ggagtagacg atgcgccggc cggcgagccg
    15421 gcgggagtcc tcgttcggca cggggctctt cctctccgcg gtgggcggcg gccggtgggt
    15481 tccgtgcgcg gtaccaaccg gggccggggt catggcggtc agcagcagga tgagggccgc
    15541 gacgcggacg gtccgtcgga gcgacggcat cggacctccc ggacaggggg acggaaccgc
    15601 agcgggacgg gaccgtgggg ggacgggact ctggagcgac atggacgaag ccgggcgcgg
    15661 ggcccgccgg ggccggccgc tccggtgcgt caggctaccg ggagccgacc cggccgggct
    15721 ccgcgcaacg cgcccgctac cccatccgcc gtagcagtcc gcccagcacc gcgacgccct
    15781 ccgtgatctc gcccggcgcg ccggccgcgt agccgagcac cagcccgggc gggtgcggca
    15841 gccgggcgtg ccaggagagc ggctgcacct tgacgccgtg ggcgagcgcg gccgtggcga
    15901 gttcggtgtc cgtgcagtcg agcccggccg ggaaggtgac catcaggtgc aacccggccg
    15961 ccgcaccgtg cacgacggcg cccggcaggt gggcgccgat cgcggcgatc atcgcgtccc
    16021 ggcgccgacg gtgacgcgga cgcagcaggc gcaggtggcg ttccagctcg ccgctctcca
    16081 tcagccgggc cagcaccagc tgcggcagga ccgcgttgcc gaggtcggcg aagcgcttgg
    16141 ccgcgaggac ggcctcgcga tggcggggcg ggacgagcag ccagccggtg cgcagggcgg
    16201 gggcgagcag cttggagacg ctgccggtgt agcagacctg ttcggggagg acgccgcgca
    16261 gcgcgggcac gggtgcgcgg tcgtaacggt gttcggcgtc gtagtcgtcc tcgatgacga
    16321 ggccgccctc gccggcccag cggagcagtt cgcggcgccg ctcgccgccg agcacgacgc
    16381 cggccgggaa ctggtgtgcg ggggtgagca ggacggcggg ggcgccggtg gcgcggagcg
    16441 cgtcgacgcg gatgccgtcg gcgtcgaccg ggacgggcgg ggtggcggtg agccagtggc
    16501 cgaggtgctg gcgggtgccg agcgagcccg ggtcctcgac cgcgacctcg gtgaggccgg
    16561 cctgcccgag cacctggccg agcagggcga gggcctgggc cgcgccggcg acgatcagca
    16621 cctcgtcggg gtcggcgcgg atgccccggt tgcgcgccag ccagtgggcg acggcccggc
    16681 ggagcgcggg ggtgccgcgg gggtcgccgt agccgaactc gtgggcggag agcctgtcca
    16741 ggacggcgcg ttcggcgcgc agccaggcgg cgcgggggaa ggcggcgagg tccgggacgc
    16801 cgggcgagag gttgatccgg gcgggggcgg cgcgcagcgc gtcgaagctc gcggggacgg
    16861 gcgcggcgtc gaacggggcg ggtgccggcg ctggaggccc ggccggcggg ggcggcgggg
    16921 cgggggtggc gacgacgacg gtgccgcccc tgccccggcc ggcgatctgg ccctcctcgg
    16981 cgagccgccc gtaggcgtcg gtgacgaccc ctcgggagac ccgcagctcg gcggcgagca
    17041 cccgggtggc gggcagtcgg ctgccggcgg ggaggcggcc gtccgcgatc gcccggcgca
    17101 gccggccggc cagccagtcg gcgagaccgc ccggcggtgc gtcggcggtg tcgagctgga
    17161 ggaagtcggc accgaccggt ttggaccggt cgacagccgg ctctatggac ctgttcacca
    17221 gtccattgtg gacgccaggg tggggacatg acgacggaga aggaattcca ggagaccacc
    17281 gcgcggccgc ggaccgccgc cccctcggag cgccacggct acgtccacgg ctattcggcc
    17341 accgaggcgc agcggctcgg tgaccaggcg gacaccctcg cggagctgct gcacgcggac
    17401 accgcgtacc cgacgggcag ccgggtgctg gaggcggggt gcggcgtcgg ggcgcagacg
    17461 ctgcacctgc tggcgggcag tcccggcgtg cggctgacgg cggccgacat ctcggccgac
    17521 tcgctcgccg aggcgcgcgc ccgggtggcg gcgcacgcgc ccggcgccaa ggtgacgtgg
    17581 caccacgggg acctgcacga gctgccgttc gccgacggcg cgttcgacca cgtcttcctc
    17641 tgcttcgtgc tggagcacct ggcggacccg gtgaccgcgc tggcagccct gcgccgggtg
    17701 ctgaggccgg gcggcacggt cacggtgatc gagggggacc acggctcggc cttcttccac
    17761 ccggagagcg ccgccgcccg cgcgacggtg gaccacctgg tgcggttgca ggccgacgcg
    17821 ggcggcgacg gcctgatcgg gcggcggctg cacccgctgc tgacggcggc ggggttcggc
    17881 gacgtcgcgg tccgcccgcg caccgtctac gcggacggga gccgcccggc gctgggggag
    17941 gggttcaccc gccgcacctt cgtcgcgatg gtcgagtcgg tgcgcgacga cgcggtcgcg
    18001 gccggcctca cctctgcggc cgcgttcgac cggggcgtcg tcgacctgcg ccgcacggcg
    18061 gaggagggcg ggacgttcca ctacaccttc ttcaaggccg tcgcggtcaa cccctgacgt
    18121 gtctccgacg atccgcgccg tgcgcccggc ggggaacgtc ggaggcgccg cggcgggcgc
    18181 ggaacgtcgg acgggccacg gcgggcgggc cggtcacccg gcctcgtcgc cctcccccaa
    18241 ggtcgcgagc accgtccgca gggcatcgat cagggcctcg gtctgctgcg ggtcgaggtc
    18301 ggccaggatg cgccgttcgg tggtgaggtg atcggggagg gcgcggtcga ccagggcatg
    18361 gccctcgggg gtgagggcga cgtcgcggct gcggccgtcg gacccgctcg gggtacgggt
    18421 caccaggcct cgggcctcca gccggtcgag gcgctggctg atcgccccgg aggtgaccat
    18481 cgcggactcc atcagcccgg tgggggtgag ccggtagggc gggccgctgc gcttcagggt
    18541 ggcgaggacg tcgaaggagg gggtgtccag gtcgtgcgcg gcgaagttcc gcttcagctc
    18601 ggcctccacc aggcgggtga ggcgtttgag ccggccgatc acctccatcg gggagacgtc
    18661 gaggtcgggg cgctccgcgc cccactgccg caccagtcgg tccacatggt ctgccaccgc
    18721 tccagcctag acgacccccc aacgatgcct tagcggtgag atacctcaca gcacccgatt
    18781 cacccggccg gacccggatg tcttagcgct gagatacatt ttccgggtgc ttaggaaccg
    18841 actcggaatc gtgctggtga ccgcgctcgc ccccgccgtc tgggggtcga cctacctcgt
    18901 caccacggaa ctgctcccgc ccaaccgccc gctgctggcc gcggtgctcc gcgcactgcc
    18961 cgccggactg ctcctcatcg ccatcacccg ccgtctgccg aagggcagtt ggtggtggcg
    19021 ctcactggtg ctgggcgctc tcaacatcgg cgcgttcatg gccctcctct tcatcgccgc
    19081 ctaccgcctg cccggcgggg tcgccgccac cgtcggcgcc gtccagccgc tgatcgccgc
    19141 aggactctcc gccgggctgc tcggcgaccg gctctcgctg cgcaccctcc tctccggcat
    19201 cgccggcgtg atcggggtca gcctgctggt gctgcgggcc aacgcccagc tcgacgccct
    19261 gggcgtcgcg gccgcgctcg gcggcgccgt cgtgatggcc accggcgtcg tcctctccaa
    19321 gcgctggacc tcgcccgccc cgctgctcgc caccaccggc tggcagctca ccgccggcgg
    19381 cctgatgctc gtcccggtcg cactcctggt ggagggcgcg ccgccgtccc acctcaccgg
    19441 cgccaacctg ctcggctacg cctacctcgg cctgatcggc gccgccgtct cgtacgcgct
    19501 ctggttccgc gggatccggg cgctgccgcc gacctccgtc accttcctcg ggctgctcag
    19561 ccccgtggtc gccaccgccc tcggctggct ggtcctcggt caggacctct cgccggtcca
    19621 gggggtcggc gcggtcatcg tgctcggctc actggtcgcc gcccagaacc agcgcccccg
    19681 gaccaccgcc ccggagagcc cgctcccccc ggccgggcag cccgcgtcgg ccgaggccgc
    19741 cgcgacgcag cagcccgtcc ccgaacccac ccgctgagca cgcacaccgc ctgaccgcac
    19801 acgccgcccg agcgcgtgca ccgcccgaga ccgcacgtcc cccttccgga actggagaac
    19861 cccatgcgca tcaccgtgtt cggcgccacc ggcaacgtcg gcagccgcgt cgtcgccgag
    19921 gccctcgccc gcggccacca ggtcaccgcc gtcctgcgcg acccggcccg gccgcacagc
    19981 ctgcccggag ccgccaccat cgccaccggc gacgcccgca ccgccgagga cgtcacccgg
    20041 ctggccaccg gccaggacgt ggtgatcagc gccacccgcc cggcccccgg cagcgagggc
    20101 gaactggcca ccgccaccaa gggcctgctg gcaggcatgg ccggaacggg cgcacggctg
    20161 cttgccgtcg gcggcgcggg cagcctcacc ctgcccggcg gcggtgccac cgtcatcgac
    20221 ggccccgact tcccgcccgg ctggctcccg atcgccctcg cctgcaacga gcagctcgcc
    20281 ctctaccggg ccgacaccga ggtcgactgg gcgtacctga gccccgccgc gctcctcgaa
    20341 ccgggcgtgc gcaccggccg ctaccgtctc ggccgggacg agctggtggt ggacgccgac
    20401 ggcacctccg ccatctccat ggaggacctc gccgtcgccc tgctcgacga ggccgagcag
    20461 cccgcccacc accgcacccg cttcaccgcg gcctactgag cgggccgggc gtcgtgcggg
    20521 tgcgaccgcg tgccggggcc cctgggccgg cggggcaggg gccccggcac atccgccgtc
    20581 aggcgccgag gcgctcgacg gtcaccttcg tgaggacgac ctcctcgacc gggcggtcgc
    20641 cgccgtcggt gtcgctcttg gcgatcgcgt ccaccacggc ggcgccctcg acgacctcgc
    20701 cgaagatggt gtgcttgccg tagaggtgcg gggtcgcgcc gaccgtgatg aagaactgcg
    20761 agccgttggt gccccggccc tgccgcttcc cggcgttggc catggccagc aggtagggcc
    20821 ggttgaagta gaggtccggg tggatctcgt cgtcgaactc gtatcccggg ccgccgacac
    20881 ccaggccgag cgggtcgccg ccctggatca tgaagccggc gatcacccgg tggaagacgg
    20941 tgccgtcgta gagccggtcg gtcgacgtct gcccggtctc cgggtgcgtc cactcgcgct
    21001 cgccctgggc gagctccacg aagttgcgga cggtcttggg cgcgtggttc gggaacagct
    21061 tgaccttgat cgtgccgagc gtcgtctcca gcgtcgcgat gaggctctct gccacgtggt
    21121 gtctccatgc ttcgtcgggc cgggggcctc gcgccgcgac cgcccccgca tttccgcgca
    21181 tacagtagtc gaccggtcgc gtccggagac cggcccggtg caccggtgcc ctcccggggc
    21241 ggctcgtcgg cgccacccgg ccggggccgg tcaccgggcc gggtgtcccg cagcgggaac
    21301 gcgttcgagg ccgggcctgc ccgccacgga ccggtggccg tcctgctgcc ggaacagccg
    21361 gccgggccac cacatccacc ggcccgcgtc cagggtcagg gctgtgacca gcaccgagcg
    21421 gacgaccacg gtgtccagca gcacgccgaa cgccaccgcg aacccgagct cggccgcgaa
    21481 caccagcggc agcgaggcca tcgccgcgaa ggtgccggcc agtaccaggc ccgccgaggt
    21541 gatcacaccc ccggtggcgg acaggccggt cagcgcgccg cgccgggtgc cgtgcagcag
    21601 cgcctcctcg cggacccggg tgaccaggaa gatgttgtag tcgatgccca gggcgaccag
    21661 gaacacgaac gtcaggagcg ggaaggaggc ctccgcgccg gcgaagtgga acacgtggtc
    21721 gaacaccagg ctgctcaccc cgagggccgc cccgaaggac agcaccaccg tcgccatcag
    21781 cagcagtggt gcgacgaccg cccgcagtag cagcgcgagg atcaggaaca ccacgaccag
    21841 cacgacgggg atgatcaccc gggagtcgcg ggcggccgcg tcctgggtgt cgaggacgac
    21901 cgccgcgttg ccgccgacct gcgcgtccgc gcccccgatc cggtggaccg cggccctggc
    21961 ctgcccgacg gtgcgcatcg cggccgtgct gccgggggcg tccttgagct cccccagcat
    22021 gacggcctca ccgtccttga ccatcggcgt cgagaccccg gcgattcccg ggacaccgga
    22081 cagcgcggcc ctcacctgct ccgccgaggc ggccctggcc accacgacga cggggtcgcc
    22141 cgagccggcc gggaagtgcc tggactggat ctcctcgccg acgaccgtct gcggcctgcc
    22201 ggtgaactgg tccgtggcgg agagcccgtc ggccttgagc ccgaacaccc cggccgccat
    22261 ggcaccgagg acgagcgcgg tgccgatcca cacgatccgc ggccggccgg agacggcggt
    22321 accgaccctg gtccagacgc ccccctcggc cgccccggcc gagccgtacg acggccgcac
    22381 cggccagaag acccagcggt cgcagatcac cagcagggcc ggcagcaggg tgaccatggc
    22441 gagcagcccc accaggatgc ccacggcaca ggccggcccg agccccttgg tggagttgag
    22501 ggtggccagc atcagcagca tcaggctgac cgcgacggtc gcggcgctgg cgacgatcgc
    22561 ggggccggaa cggcgcagcg cctccgccat cgcctcgtgc cggtcctcgt gcc
//
