LOCUS       NZ_CP012673            10861 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Sorangium cellulosum strain So ce26 chromosome, complete genome.
ACCESSION   NZ_CP012673
VERSION     NZ_CP012673.1
KEYWORDS    RefSeq.
SOURCE      Sorangium cellulosum
  ORGANISM  Sorangium cellulosum
            Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae;
            Sorangium.
REFERENCE   1  (bases 1 to 14557589)
  AUTHORS   Zaburannyi,N., Bunk,B., Overmann,J. and Mueller,R.
  TITLE     Sorangium comparison
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 14557589)
  AUTHORS   Zaburannyi,N., Bunk,B., Overmann,J. and Mueller,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-SEP-2015) Department of Microbial Natural Products
            (MINS), Helmholtz Institute for Pharmaceutical Research Saarland
            (HIPS), Campus E 8.1, Saarbruecken, Saarland 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: SMRT portal v. 2.2.0, HGAP v. 3.0
            Genome Coverage                   :: 134x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002950945.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 11:58:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,531
            CDSs (total)                      :: 10,457
            Genes (coding)                    :: 10,397
            CDSs (with protein)               :: 10,397
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 6 of 60
            Pseudo Genes (incomplete)         :: 58 of 60
            Pseudo Genes (internal stop)      :: 2 of 60
            Pseudo Genes (multiple problems)  :: 6 of 60
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:39:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10661147
            Orig. end                         :: 10672008
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012673.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from German Collection of Microorganisms and
            Cell Cultures GmbH, Inhoffenstrasse 7B, 38124 Braunschweig,
            Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10861
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="35"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10861
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10861
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5861](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5861
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    139..152
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.78"
                     /tool="antismash"
     misc_feature    1055..1070
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.95"
                     /tool="antismash"
     gene            complement(1364..3592)
                     /locus_tag="SOCE26_RS38560"
                     /old_locus_tag="SOCE26_077690"
     CDS             complement(1364..3592)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012239144.1"
                     /locus_tag="SOCE26_RS38560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_077690"
                     /product="DUF3160 domain-containing protein"
                     /protein_id="WP_104984492.1"
                     /transl_table=11
                     /translation="MRKILRHVHVVPLLLALAGCSGEPGASPPVEGTKPPPTQVGPEQK
                     AELEALLAEREASASLTAEDFARKYAVSFAAGLPYAPAEAEHMPLLQGTALALDEGELA
                     KLSRSGFVISERHHFPTFVYGYESIYALDLPLYVSADSILYAVHRSYDAILKAVELTSL
                     ATELGTMLEEMRAELASGAGGELGAEARADADLFTAVALALLKGAPVAPVAGASAATID
                     ELVAGAKAHQGTAAVRLFGSDRIMDFSQFEPRGHYTDHETLQRYFRSMMWLGRVDFRFL
                     ETQQDGTQVFQRRQLEGAYVLRALADEKTLGRYKRIDDTIQAFVGESDTMTLPELDELL
                     ADLGLGGAAGLAGVPDDRIAAVLVEKGHGTQRISSHIMINGLDKGTLPLSSSFALLGQR
                     YVVDSHVFSNVVYDRVRGGTLKRMMPNPLDVGFAALGNDQAGHLLAPELGQFPYAPDLH
                     MMRVLVDAHPADFWSKNLYNRWLAALRELSPARTLADAAGLPEVAKTEPWGRRLLNTQL
                     ASWAELRHDTLLYAKQSYTGGATCEFPDAYVDPYPAFYARIAEMAEHGGKVVEALDLSS
                     SPWLAQAVPTYFSRLHSVAKTLGEMAENERAGLPLTPAHLDFINQAVKVQQGCGSPAGA
                     EGWYAQLFFDVMESVTEDPTIADVHTQPTDEGGAPVGRVLHVGTGFPRLMVVTADPCGT
                     PRAFVGLASSYFEKITEGFERMTDEQWAASIVSTTPADVPWMQDIVAR"
     misc_feature    complement(3651..3664)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            3986..4993
                     /locus_tag="SOCE26_RS56135"
                     /old_locus_tag="SOCE26_077700"
     CDS             3986..4993
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012240313.1"
                     /locus_tag="SOCE26_RS56135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_077700"
                     /product="MopE-related protein"
                     /protein_id="WP_199789423.1"
                     /transl_table=11
                     /translation="MTNSSGSTLFALALAGFAAFTPACGDDDGSPPGTETPTGAGGSGA
                     GGAGGAGGDGNGGAGGDGDEGGAGAGGQPVDDEDSDHDRDGFTPRAGDCDDFNNTVHPG
                     AEEQNLDDVDADCDGSDAPAKTLVWSGDEDANLVDAVALMDADGDGQISLAEFSAKCAE
                     SAMLMGTARPGVVQVHASCAGTNSCRGMVYQTWNEIHEHSCRAVNSCAGWSCVETAEDQ
                     GRDGPASFQAGTCNHCHSGPAGTFTVQVPPGEDVSAFLADFWDRRSDLFLQSIIAFGIR
                     GVTAEGYAYSNMPGSHHLLSRAEMDRLIAHLRTLTPEGENFEQLPPAEPIDPGH"
     gene            5001..5861
                     /locus_tag="SOCE26_RS38570"
                     /old_locus_tag="SOCE26_077710"
     CDS             5001..5861
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012240314.1"
                     /locus_tag="SOCE26_RS38570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_077710"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_104984493.1"
                     /sec_met_domain="DUF692 (E-value: 2e-79, bitscore: 265.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPQHPAGARAPDARAISRDALGLGLRPQHYDEIERLRPELGFF
                     EIIAENYLGASKLPRERLRRIAERYPIVAHGVSLNLLGEAPLDRDYLSRLKDLIQELRI
                     PYFTDHLCWTAFEGVTHHDLLPAPYDPELIPYAAGRAFEVQEALGVPFGIENLSSYVAW
                     ERDTVPEWVFYRRVVEESGCWTMLDLNNVFVSSQNHGFDPGEYLDSVPWPRVLQVHLAG
                     HQTLPSGLRHDTHDRPVDDEVWCLYQEAWRRGGPFPTLLEWDAEIPPLPVALSELDKAR
                     RVRPT"
     gene            5858..6844
                     /locus_tag="SOCE26_RS38575"
                     /old_locus_tag="SOCE26_077720"
     CDS             5858..6844
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020740748.1"
                     /locus_tag="SOCE26_RS38575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_077720"
                     /product="DNA-binding domain-containing protein"
                     /protein_id="WP_104984494.1"
                     /transl_table=11
                     /translation="MSSRGGDPPRWLRELQRDFTAVLRTPLDSGTGTFRERQDRYPERL
                     VAQLKSGPGSPAPAERLALYHRQYWMRLFTALQTGFPRVSRAVGYWHFNHLAALHLTAR
                     PPRHVDIDEATRGFSAQLGGALQRLDEVKRGRGPRRPARDDAWCRRLELSRAPRAMIRQ
                     ALRMDEAERHAYESPFEGIWRPTPPELGRLAEGRLRFAVSCTLADEDWDLARFSRLTGA
                     HQDEGAPDVVRRHPSTRTWVFARSATGTAMTCVDPLFARLLGRCRELPFGQALAAVEHG
                     CMAAEAAQLRDHLQGWIRLALASGWWTGLDDAEPHAQESPIDGPSRT"
     gene            7076..7702
                     /locus_tag="SOCE26_RS38580"
                     /old_locus_tag="SOCE26_077730"
     CDS             7076..7702
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_process="GO:0006749 - glutathione metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_N_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1193: glutathione S-transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020739613.1"
                     /locus_tag="SOCE26_RS38580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_077730"
                     /product="glutathione S-transferase family protein"
                     /protein_id="WP_104984495.1"
                     /sec_met_domain="GST_N_3 (E-value: 6.1e-15, bitscore: 54.6,
                     seeds: 52, tool: rule-based-clusters)"
                     /sec_met_domain="GST_C (E-value: 6.8e-09, bitscore: 35.1,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSITFYYAPQSNATRIRWTLAELGVPCETVRVDLRAGDQKKPEFL
                     ALNPNGKVPTLVLDGTPIFESVAIQIALGERYGVEKGLWPAPGSPERLTALSWLVWGQV
                     SFATTLFRYMTNTSDYFPEEQRNAKQAELALGELHNLLRILDARLDGRPYVAGETFTLA
                     DLDLAAVLGWGLSWAKVDISNLPNVQGWLGRTTGRPAAKAVLAET"
     misc_feature    complement(7085..7101)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.01"
                     /tool="antismash"
     gene            7791..9887
                     /locus_tag="SOCE26_RS38585"
                     /old_locus_tag="SOCE26_077740"
     CDS             7791..9887
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020739614.1"
                     /locus_tag="SOCE26_RS38585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_077740"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_104984496.1"
                     /transl_table=11
                     /translation="MTVLQVADLSFGYGADKLFQGITFSLELGQRAALVAPNGAGKSTL
                     LRLIARELTPDTGSVVIRKGIRIAYFRQSHELQAEGNVLDAFLSGFSEVLELRHALTAA
                     QLAAASGSEADLARLSDLTDRYHIAGGDDLERRVEIIAAHLGFRPADMDRPVASLSGGE
                     RGRLQLGVVLAIEPDLLLLDEPTNHLDIETITWLEKHLAGLGGALLCISHDRAFLDAVC
                     PNTMELGQRSFRVYPLKYSDYAVAREEDLARERELAERQEAFVAKTEEFIRRNIAGQKT
                     KQAQSRRKMLDKLEAIDRPEDVWATAEKVRFRFAPAPRSGDIVLDARGLGAARGGRTLF
                     SGVDLLIRRGDRVGIVGPNGTGKSTLLKLLAGVGAPEDDGEVKRGTNLCQGYFDQHLGT
                     LDPSRTAVEEIRSVRADMNVDATRQYLSRFRFYGDDALRKVQGFSGGERSRLALGKLLL
                     EPRNLLFLDEPTNHLDIPAAEILEEALTGFEGTVVLVSHDRRFLERVTTRIVAVREGHV
                     DVYPGGFRDYRDNLEKLAAEQAAREAEERGAAQRGPARGARQNGAAAAAPRDEARSAPD
                     DRGGGAKPARAVRRSGATMPPPDGGGAEDAAARRRAFESDKAAARAAERKRKRVKELEV
                     EIAEGESQLAAMREALKKDPGGDWAKLAEAARKEQALAKRVDAAMTEWMALSEELGAAA
                     GGGA"
     gene            9884..10648
                     /locus_tag="SOCE26_RS38590"
                     /old_locus_tag="SOCE26_077750"
     CDS             9884..10648
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012239147.1"
                     /locus_tag="SOCE26_RS38590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_077750"
                     /product="glutaredoxin domain-containing protein"
                     /protein_id="WP_234022838.1"
                     /transl_table=11
                     /translation="MTGAARVALRGLARAAAVLLALAAAAPACDEKRDDGTTPAAAPAE
                     LPPLELRDDTANLMLTWIDAQGDTHVELRPADVPAEGRALVRAMLSDRTEGTRDVFYVA
                     DLTQKRPDGTYVVRSMLRREWEALLEKRRAEHLAKTAPPPAAAGPAGSAGAGAPAAPSS
                     LSGVTVIIYGASWCKPCHQAADYLRAKGVAAIVKDIEEDPAAAAEMQDKLAKSHQRGGS
                     IPIIDVRGQILVGFSPGALDKALARAAGGVTL"
ORIGIN
        1 cgcttcgcga acgggctgct cgacgcgccg ctcttccggt cgctcgtggc ccgcgccgag
       61 gggccgcccg aggaggccgc gggcgcggcg acaggggcgg cgccgcgccg cggccgggtc
      121 cgctgggaga gcgcgccgct cacgctgcgc gagctgctcc aggcgcaccg ggcgggcgtg
      181 ctccggccga tggagagcgc cccgcgggac gaggcgcggc gcaccgcccg ctggcccgcg
      241 ggcgcggcgc gggatgtggc cggcgcgccg cccgaggagc tcgtgtacct cgcgatggag
      301 gagccgctcg cgcaggcgtt ctggcggcgc ctcgcgacgc tcgacggggg cgccgcggcg
      361 gcgcaggccg cgccgggcgc tgcggcggcg ccgccgcgcg cgccgggcgc cgcgccgtgc
      421 ccgatgcccc gtacgtcgtg cgacgtgctc ctggcgacgg ccggcgatgt ccccggcgtc
      481 cgcgccgccg cggcggccat ggggatcctc gagcgcatcg acgcgtcgat ctccgcgtcg
      541 gcggacctgc cggcgtcgcc gatctgggtg caccaggacc tctacgggcc ggacgagatg
      601 gcgcacacgg acggcagcgg catcagcgtg aacctcgcct ccggccgggt gcgggcgctg
      661 ctcacggcgg tgctcgtgcg cgacgatgcc gtcgccttca gcgcgctcgt cgatctgctg
      721 ctgcacgaga agacgcacgt ctcgctggcc acctacgtcc cgcggcccac ggccgagcac
      781 ggaacgagct tctaccgccg caaggactgg atgcggcgcc ggctgctcgc gggcatcgcg
      841 agcggcgccg tcgccgatcc gatgcggtgg ctcgcgagcg cgcggcgagg gctcgtgagc
      901 gcggcgctgc cggcgccggc ggagctcacg cgggcgttcg agggggcggc ggcggcggcg
      961 tgaggcgggc ccgggttcgc cgggatcggt gagcgggccg ccttggaggc tgcgttcagt
     1021 ccagctcgga ggctgtccgg aggccccggg ctgaattgaa gttcaacctc aaggctgtcc
     1081 aaagggtggt gggtgcgtcg gccgaaggtg gggtctttgg gaccgccaag ataccaagac
     1141 gccaagatac caaaaggaat cacggagtct tggcgtctta tggcgccttg gcggttccat
     1201 cattccggca aggtggagga gttcccccca ccacacggca aaccgtgatc gcgctgacgc
     1261 acgtgccggc acagtacggc acaagctccg gaggcgctcg atcgtgccgg agcgggccct
     1321 gggcgacgag atcagcaggc ggcgagcgcg gtgccagccg aggtcatcgg gccacgatgt
     1381 cctgcatcca ggggacgtcg gcgggggtcg tcgacacgat cgaggcggcc cactgctcgt
     1441 cggtcatgcg ttcgaagccc tcggtgatct tctcgaaata cgaggaggcg agccccacga
     1501 aggcgcgcgg ggtgccgcag ggatcggccg tcacgaccat caggcggggg aagccggtgc
     1561 ccacgtgcag cacgcggccg accggcgccc cgccctcgtc ggtgggctgg gtgtgcacgt
     1621 cggcgatcgt ggggtcctcg gtcacgctct ccatcacgtc gaagaagagc tgggcgtacc
     1681 agccctcggc gccggcgggg gagccgcagc cctgctggac cttgacggcc tggttgatga
     1741 aatcgaggtg cgcgggcgtg aggggcaggc cggcgcgctc gttctcggcc atctcgccga
     1801 gcgtcttcgc gacgctgtgc aggcgcgaga agtaggtggg caccgcctgg gcgagccacg
     1861 gggagctcga caggtcgagg gcctcgacga ccttgccgcc gtgctcggcc atctcggcga
     1921 tgcgggcgta gaacgcgggg tacgggtcca cgtacgcgtc cgggaactcg cacgtggcgc
     1981 cgcccgtgta cgactgcttg gcgtagagca gcgtgtcgtg ccggagctcg gcccaggagg
     2041 cgagctgcgt gttgagcagg cgccggcccc agggctccgt cttcgccacc tcgggcagcc
     2101 ccgccgcatc ggcgagcgtc cgcgccggcg acagctcccg cagcgcggcg agccagcggt
     2161 tgtagaggtt cttgctccag aaatcggccg ggtgggcgtc gacgagcacg cgcatcatgt
     2221 gcaggtcggg cgcgtagggg aactggccga gctcgggcgc gagcaggtgg cccgcctggt
     2281 cgttgccgag cgcggcgaag ccgacgtcga gcgggttcgg catcatgcgc ttcagggtgc
     2341 cgccccggac gcggtcgtag accacgttcg agaacacgtg ggagtcgacc acgtaccgct
     2401 ggccgagcag cgcgaagctc gacgagagcg gcaacgtgcc cttgtcgagg ccgttgatca
     2461 tgatgtggct cgagatccgc tgcgtcccgt ggcccttctc gaccaggacc gcggcgatgc
     2521 ggtcgtccgg gacgccggcg aggccggccg cgccgccgag gccgaggtcc gcgagcagct
     2581 cgtcgagctc cgggagcgtc atggtgtcgc tctcgccgac gaaggcctgg atggtgtcgt
     2641 cgatgcgctt gtaacggccg agggtcttct cgtccgcgag cgcgcgcagc acgtacgcgc
     2701 cctcgagctg ccgccgctgg aagacctgcg tgccgtcctg ctgcgtctcc aggaagcgga
     2761 agtcgacgcg gccgagccac atcatgctgc ggaagtagcg ctggagcgtc tcgtggtccg
     2821 tgtagtggcc gcgcggctcg aactgcgaga aatccatgat gcggtccgac ccgaagaggc
     2881 gcaccgcggc ggtaccctgg tgggccttgg cgccggccac gagctcgtcg atcgtcgcgg
     2941 cgctggcgcc cgcgacgggc gcgacggggg cgcctttgag cagcgcgagc gccacggcgg
     3001 tgaacaggtc cgcgtcggcg cgcgcctccg cgccgagctc gccgccggcg cccgaggcga
     3061 gctcggcgcg catctcctcg agcatcgtcc cgagctcggt cgcgagcgag gtgagctcca
     3121 cggccttcaa gatcgcgtcg tacgagcggt gcacggcgta caggatggag tcggcggaca
     3181 cgtagagcgg caggtcgagc gcatagatgc tctcgtagcc gtagacgaag gtcgggaagt
     3241 gatgccgctc cgagatgacg aagccgctcc tcgacagctt ggcgagctcg ccctcgtcga
     3301 gcgcgagcgc ggtgccctgg agcagcggca tgtgctccgc ctccgcgggc gcgtagggca
     3361 ggcccgcggc gaaggagacg gcgtacttcc gggcgaagtc ctcggcggtc aaactcgccg
     3421 aggcctccct ctcggcgagc agcgcctcga gctccgcctt ctgctcggga ccgacctgcg
     3481 tgggcggggg cttcgtgccc tcgacgggcg gcgaagcgcc cggctcgccc gagcagccag
     3541 cgagggcgag gaggagcggg acgacgtgaa cgtgacgaag gatcttgcgc atcgtgttcc
     3601 ccttccagcg cgcgccccct tgaccccggg gcgcggcgcc cccggtgcga gcaaggacgg
     3661 tgccgcgggc ggcctccacg ggagacggcg acgggatggc gttcctccag gtgaatggcg
     3721 gtgatccctg acgcggggat cacatcctgc ttgggccggg cacaaccgcg ctgcgcacgg
     3781 aagagggaca ggcgcgatgg gtcgggtcga tttcatcgcc agggcaggcg cgcaggaggc
     3841 caatcggcgt ctcgcgctcc gtacctgacg aagagttgcc tgcgacaaag tgccgcatgt
     3901 tcgccgcgcg gcatccttgg ttataagtcc tgcgccggga ggccggcagg accgcgcagc
     3961 gcggcccttc agagagagga cgatcatgac gaactcgtcg ggatccactt tgttcgcgct
     4021 ggccctggcc ggctttgccg ccttcacgcc ggcctgcggc gacgacgacg gttcgccccc
     4081 cggcaccgag acgcccaccg gagccggcgg ctccggcgcg ggaggcgcag ggggcgcggg
     4141 cggcgatggg aacgggggcg cgggcggcga tggggatgag gggggcgcgg gcgcaggtgg
     4201 ccagcccgtg gacgacgagg acagcgacca cgacagggac ggcttcaccc cacgtgcagg
     4261 cgactgcgac gatttcaaca acactgtcca ccccggcgcc gaggagcaga acctcgatga
     4321 cgtcgacgcg gactgcgatg gatcggacgc gccggccaag acgctggtgt ggagcggcga
     4381 cgaggatgcc aatctggtgg acgcggtggc cctcatggat gcggacggcg acggccagat
     4441 ctccctcgcc gagttctccg cgaagtgcgc cgagtccgcc atgctgatgg gcaccgcgcg
     4501 ccccggggtg gtccaggttc acgcgagctg cgccggcacg aacagctgcc gcggcatggt
     4561 ctatcagaca tggaacgaga tccacgagca ctcctgccgc gccgtgaact cctgcgcggg
     4621 ctggagctgc gtggagaccg ccgaggacca gggccgagac ggaccggcgt cgttccaagc
     4681 tgggacgtgc aaccactgcc actcgggccc ggccggcacg ttcaccgtgc aggtgccgcc
     4741 cggcgaggac gtgagcgcct tccttgcgga cttctgggac cgtcgctcgg atctgttcct
     4801 gcagtccatc atcgcgttcg ggatccgcgg cgtcaccgcc gagggctacg cctactcgaa
     4861 catgcccggc tcccaccacc tgctgtcgcg cgccgagatg gaccggctca tcgcccacct
     4921 gcgcaccctc acgccggagg gcgagaactt cgagcagctg ccgccggcag agccgataga
     4981 tcccggccac taggccgccg atggctgcgc cgcaacaccc cgccggcgcc cgggcgcccg
     5041 acgcgcgcgc gatctcgcgc gacgcgctcg gcctcggcct gcgtccgcag cactatgacg
     5101 agatcgagcg gctccggccc gagctgggct tcttcgagat catcgcggag aactacctcg
     5161 gcgcatcgaa gctcccccgg gagcggctcc ggcgcatcgc cgagcgctac ccgatcgtcg
     5221 cccacggcgt ctccctgaac ctgctcgggg aagcccccct cgacagagac tacctgtccc
     5281 ggctgaagga cctgatccag gagctccgca ttccttactt cacggatcac ctctgctgga
     5341 cggcgttcga gggcgtgacg caccacgacc tcttgcctgc tccctatgat ccggagctga
     5401 tcccctacgc ggccggccgg gcgttcgagg tccaggaggc gctcggcgtg cccttcggga
     5461 tcgagaacct gtcgtcctac gtggcctggg agcgcgacac ggtgccggag tgggtgttct
     5521 accgccgcgt ggtggaagag tccggctgct ggaccatgct ggacctcaac aacgtgttcg
     5581 tctccagcca gaatcacggg ttcgatccgg gcgagtacct cgacagcgtg ccttggcccc
     5641 gggtcttgca ggtccacctg gccggccacc agacgttgcc ctcgggcctg cggcacgaca
     5701 cgcatgaccg tcctgtagac gacgaggtgt ggtgtctcta ccaggaggcg tggcgccggg
     5761 gcggcccttt cccgacgctg ctcgagtggg acgcggagat cccgcccttg cccgtggccc
     5821 tctcggagct cgacaaggcg cggcgggtgc ggcccacatg agctcgagag gtggagatcc
     5881 tccgcgctgg ctgcgagagc tccagcgcga cttcaccgcg gtcctccgca cgccgctcga
     5941 ctcgggcacg ggcaccttcc gggagcgcca ggatcggtat cccgagcggc tcgtggcgca
     6001 gctgaagagc ggccccggga gccccgcccc ggcggagcgg ctcgcgctct accaccgcca
     6061 gtactggatg cggctgttca ccgccctgca gacgggcttc ccccgcgtct cgcgggcggt
     6121 gggctactgg cacttcaacc acctggccgc gctgcacctc accgcgcgcc cgccgcggca
     6181 cgtcgacatc gacgaggcga cccgcgggtt ctccgcgcag ctcggcggcg cgctgcagcg
     6241 cctcgacgag gtgaaacgcg gccgcggacc gaggcgcccc gcgcgcgacg acgcgtggtg
     6301 ccggcggctc gagctctcca gggccccgcg cgccatgatc cgccaggcgc tgcgcatgga
     6361 cgaggcagag cggcacgcct acgagtcgcc gttcgagggg atctggcgac cgacgccgcc
     6421 ggagctcggc aggctggccg aggggcggct gcgcttcgcg gtgtcctgca cgctggccga
     6481 cgaggactgg gacctcgcgc gcttctcgcg gctcacgggg gcccaccagg acgaaggcgc
     6541 gccggacgtg gtacgtcgtc acccatcgac gcgaacctgg gtcttcgccc ggagcgccac
     6601 cgggacggcc atgacctgcg tggatccgct gttcgcccgc ctgctcgggc gctgccggga
     6661 gctgccgttc gggcaggcgc tcgcggccgt cgagcacggc tgtatggcgg cggaagcagc
     6721 gcagctgcgg gatcatctgc agggctggat ccggctcgcc ctcgcgagcg gctggtggac
     6781 gggcctcgac gacgccgagc cgcacgcgca ggagagcccg atcgacggtc cgagccggac
     6841 gtgagccccg aaagcgccgt tcagagagac ggcgggagtc catcgaagct gtcaaccccg
     6901 agcctcaatc ccctcgccct cgctcgacca acaaccaccg tcgaaatctt gctctgcatg
     6961 gcaaaactga cgcttactgc ctcccagcgg aatcgccgac aagctcgcgt ctcgctgcgc
     7021 gcaaggcgtg acatcgccgc tccggatcca ctacaagggg cgccggaggc caaccatgtc
     7081 catcacgttc tattatgccc ctcagagcaa cgcgacgcgc atccgctgga cgctcgccga
     7141 gctcggcgtc ccctgtgaga ccgtccgggt cgatctgcgc gcaggcgacc agaagaagcc
     7201 ggagttcctg gccctcaacc ccaacggcaa ggtgccgacc ctcgtcctcg acggcacccc
     7261 gatcttcgag tcggtggcga tccagatcgc cctcggcgag cggtacggcg tcgagaaggg
     7321 cctgtggccg gcccctggct cgcccgagcg cctcacggcc ctgagctggc tcgtctgggg
     7381 tcaggtcagc ttcgccacca ccctgttccg ctacatgacg aacacgagcg attatttccc
     7441 ggaggagcag cgcaacgcga agcaggccga gctcgccctc ggcgagctgc acaacctgct
     7501 ccgcatcctc gacgcccgcc tcgacggccg tccctacgtc gccggcgaga ccttcaccct
     7561 cgccgacctc gacctcgccg cggtgctcgg ctggggcctc agctgggcca aggtcgacat
     7621 atccaacctg ccgaacgtcc agggctggct cggccgcacg acggggcgcc cggccgcgaa
     7681 ggcggtgctc gccgagacct gagccccgcg ctcgccgtcg cggcccacac gccggagctc
     7741 cgccccgggc gcgcttgcgc gcgcccgacc catgctagaa ctcggccgca atgacggtcc
     7801 tccaggtcgc cgacctcagc ttcggttacg gcgccgacaa gctcttccag ggtatcacct
     7861 tttccctgga gctcggccag cgcgccgcgc tcgtcgcccc caacggcgcc ggcaaatcca
     7921 ccctgctccg cctgatcgcc cgggagctca ccccggacac gggctcggtc gtgatccgca
     7981 aagggatccg gatcgcctac ttccggcagt cgcacgagct ccaggccgag ggcaacgtgc
     8041 tcgacgcctt cctctccggg ttctccgagg tgctggagct gcgccacgcc ctcaccgcgg
     8101 cgcagctcgc cgccgcgagc ggcagcgagg ccgacctcgc ccggctcagc gacctcaccg
     8161 accgctacca catcgccggc ggcgacgacc tcgagcgccg cgtcgagatc atcgcggccc
     8221 acctcgggtt caggcccgcc gacatggacc gccccgtcgc cagcctgtcc ggcggcgagc
     8281 gcggccgcct gcagctcggc gtcgtgctcg cgatcgagcc cgacctcctc ctgctcgacg
     8341 agccgacgaa ccacctcgac atcgagacca tcacctggct cgagaagcac ctcgcggggc
     8401 tcggcggcgc gctgctctgc atctcgcacg accgcgcctt cctcgacgcc gtctgcccga
     8461 acaccatgga gctcggacag cgcagcttcc gggtctaccc gctcaagtac agcgactacg
     8521 cggtcgcccg cgaggaagac ctcgcccgcg agcgggagct cgccgagcgg caggaggcgt
     8581 tcgtcgccaa gaccgaggag ttcatccggc gcaacatcgc cggccagaag accaagcagg
     8641 cgcagagccg gcgcaagatg ctcgacaagc tcgaggccat cgaccggccc gaggacgtct
     8701 gggcgaccgc cgagaaggtc cggttccggt tcgcgcccgc gccgcggagc ggggacatcg
     8761 tgctcgacgc gcgcggcctc ggcgccgccc gcggcggccg caccctcttc tccggcgtcg
     8821 acctcctgat ccgccgcggc gaccgggtgg gcatcgtcgg accgaacggg accggcaaat
     8881 cgacgctgct caagctcctc gcgggcgtcg gcgcgccgga ggacgacggc gaggtgaagc
     8941 gcggcacgaa cctctgccag ggctacttcg accagcacct cggcacgctc gacccgagcc
     9001 ggaccgccgt cgaggagatc cgcagcgtcc gcgcggacat gaacgtcgac gccacgcggc
     9061 agtacctgtc gcggttccgg ttctacgggg acgacgcgct ccggaaggtg caggggttct
     9121 cgggcggcga gcggagccgg ctggcgctcg gcaagctgct gctcgagccg cgcaacctgc
     9181 tcttcctcga cgagccgacg aaccacctcg acatccctgc ggccgagatc ctcgaggagg
     9241 cgctcacggg gttcgagggg acggtggtgc tcgtgtcgca cgaccggcgg ttcctggagc
     9301 gcgtgacgac gcgcatcgtg gcggtgcgcg aggggcacgt ggacgtctat cccggcggct
     9361 tccgcgacta ccgggacaac ctcgagaagc tcgcggccga gcaggccgcg cgcgaggcgg
     9421 aggagcgcgg cgcggcgcag cgcgggccgg cgcgcggcgc gcggcagaac ggcgccgcgg
     9481 cggccgcgcc gcgcgacgag gcgaggtccg ctccggacga ccggggcggg ggcgcgaagc
     9541 ccgcgcgggc ggtgcggcgg agcggcgcga cgatgccgcc gccggacggc gggggcgcgg
     9601 aggacgcggc ggcgcgccgg cgggcgttcg agagcgacaa ggccgcggcg cgggccgcgg
     9661 agcgcaagcg caagcgggtg aaggagctcg aggtggagat cgccgagggc gagtcgcagc
     9721 tcgcggcgat gcgcgaggcg ctgaagaagg accccggcgg cgactgggcg aagctcgcgg
     9781 aggcggcgcg caaggagcag gcgctcgcga agcgcgtcga cgcggcgatg accgagtgga
     9841 tggcgctcag cgaggagctc ggcgcggcgg cggggggcgg ggcgtgacgg gggcggcgcg
     9901 cgtcgcgctg cggggcctcg cccgcgccgc cgcggtgctg ctcgcgctgg ccgcggccgc
     9961 gccggcctgc gacgagaagc gcgacgacgg caccacgccg gcggcggccc cggccgagct
    10021 gccgccgctc gagctgcgcg acgacacggc gaacctgatg ctcacgtgga tcgacgcgca
    10081 gggcgacacc cacgtcgagc tccgcccggc cgacgtcccc gccgaggggc gcgcgctcgt
    10141 gcgcgccatg ctgtcggacc ggaccgaggg cacacgcgac gtgttctacg tcgcggatct
    10201 gacgcagaag cgcccggacg gcacgtacgt ggtccggagc atgctgcggc gggaatggga
    10261 ggcgctgctg gagaagcggc gcgccgagca cctcgcgaag acggcgcccc cgcccgcggc
    10321 agcgggcccc gccggctccg cgggcgccgg cgcgcccgcg gccccgagca gcctgagcgg
    10381 cgtgacggtg atcatctacg gcgcctcatg gtgcaagccg tgccaccagg ccgcggacta
    10441 cctgcgggcc aagggcgtcg ccgcgatcgt caaggacatc gaggaagatc cggccgcggc
    10501 cgcggagatg caggacaagc tcgcgaagag ccaccagcgc gggggcagca tcccgatcat
    10561 cgatgtccgc ggacagatcc tcgtcgggtt cagcccggga gcgctggaca aggcgctcgc
    10621 gcgggcggcg ggcggggtga cgctctgacg gcgccggcgg cgggcgcaga ggaggtccag
    10681 cgcggcgggg tgcggagctg aagctgcgcc gttcagagcg gcggacaccg ctcgctggcc
    10741 cggctccggg aaccagtgtt acaacgacat cacacgccgc cctcgatcgg gaaggcgccg
    10801 ggacggcgcc ttccccgcga atcatcatgc caagcacagg aaatcacaga aaggaatgaa
    10861 c
//
