LOCUS       NZ_CP012673            22221 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Sorangium cellulosum strain So ce26 chromosome, complete genome.
ACCESSION   NZ_CP012673
VERSION     NZ_CP012673.1
KEYWORDS    RefSeq.
SOURCE      Sorangium cellulosum
  ORGANISM  Sorangium cellulosum
            Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae;
            Sorangium.
REFERENCE   1  (bases 1 to 14557589)
  AUTHORS   Zaburannyi,N., Bunk,B., Overmann,J. and Mueller,R.
  TITLE     Sorangium comparison
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 14557589)
  AUTHORS   Zaburannyi,N., Bunk,B., Overmann,J. and Mueller,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-SEP-2015) Department of Microbial Natural Products
            (MINS), Helmholtz Institute for Pharmaceutical Research Saarland
            (HIPS), Campus E 8.1, Saarbruecken, Saarland 66123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: SMRT portal v. 2.2.0, HGAP v. 3.0
            Genome Coverage                   :: 134x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002950945.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 11:58:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,531
            CDSs (total)                      :: 10,457
            Genes (coding)                    :: 10,397
            CDSs (with protein)               :: 10,397
            Genes (RNA)                       :: 74
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 6 of 60
            Pseudo Genes (incomplete)         :: 58 of 60
            Pseudo Genes (internal stop)      :: 2 of 60
            Pseudo Genes (multiple problems)  :: 6 of 60
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:39:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2599359
            Orig. end                         :: 2621580
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP012673.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from German Collection of Microorganisms and
            Cell Cultures GmbH, Inhoffenstrasse 7B, 38124 Braunschweig,
            Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22221
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="11"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22221
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22221
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12221](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12221)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            956..2533
                     /locus_tag="SOCE26_RS09825"
                     /old_locus_tag="SOCE26_019660"
     CDS             956..2533
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012233970.1"
                     /locus_tag="SOCE26_RS09825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019660"
                     /product="DUF1552 domain-containing protein"
                     /protein_id="WP_104978354.1"
                     /transl_table=11
                     /translation="MKRWITRRNLLRGAGVCLALPWLESLSPRSARAGDAGTPKRFLLC
                     TFPNGAPHHWWETAPAFGKTLTGADFKLPRVLEHFAPVKSKMLMISRLGNYTWNKELSP
                     YVEPSHSRLTAALSTCVDADQLGRDQGQDLGAWVGNGVSVDQLIVQKIGPEQATRIPSL
                     QTGLGVKPGYFDERSYAYNQAISWKSPREPLKRSVNPRAVFDALVGAGAASAAPVPGQT
                     EGQARIEAARRAAAEKSVIDAVLADANALKGRVGAEDRRIVEQYLDALREIEKNATRVA
                     ATMNPANLGCAPIPEPGVVPEPPGQAEGLNENDSTEAGEYRHEDHANVMTDLLVMAIQC
                     DVTRVVTHMLDDARSEFEYRCIPEEVRAKVGLEYRAESSLHFHASQHGAGNLDRAIEDG
                     RYRIIQPSNAEFAAINCWLGQKTAELAQRLDAIPEGDGTVLDHSVMVYMSEMRTHDHDA
                     YDLPIVLLGGGGVFLNDAHVAYDALGSDRQLRDLWFTIMNQYYGLEVASFGDDTRGEPN
                     ALLEEILR"
     gene            2584..3603
                     /locus_tag="SOCE26_RS09830"
                     /old_locus_tag="SOCE26_019670"
     CDS             2584..3603
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020735641.1"
                     /locus_tag="SOCE26_RS09830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019670"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_104978355.1"
                     /transl_table=11
                     /translation="MPDDELVFASMPAALISFACSRGVPQDDLLRAAGVSAEALAAPDE
                     LVPYGSLLGLWELLLRRFPGEPLGLSYAQWIPVSVVGIVGHAIRHSETLRQGVAVYARF
                     CRLMDPHLRLAVEEHGEVVHLALEHEPRVVAMAEPMEMMIAALARFIALYLDGAARPAE
                     ARFRHARRHPPARYEEAIGVPARFEAASTCLVYDARFLDAPVVGADPSVHDYLVRQAER
                     LLAARAAPAGAAPLDARVRARIDERIERGEVEQEQIARALGMSTRSLQRALKDLGTSFT
                     AQLDEVRRARALELVRRRDVTLQEIAFLLGYGEPRHFYRSFRRWTGSTPGEYRRANAR"
     gene            3714..4964
                     /locus_tag="SOCE26_RS09835"
                     /old_locus_tag="SOCE26_019680"
     CDS             3714..4964
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024700.4"
                     /locus_tag="SOCE26_RS09835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019680"
                     /product="ATP-binding protein"
                     /protein_id="WP_104978356.1"
                     /transl_table=11
                     /translation="MLRRVHIRGFKTAIDAVLDLGRLNVFVGPNGAGKSNLLEAIAVLG
                     CAASGRVDYDAFRARGIRPGKPGLLKTALSSEKRAARTILLEAVSDSTRYQVVLGDSAL
                     GRGASTGSAAWRFDKETFSEGEQEVGSRSKGEGYLVHADGARQAITARLDRGIAPLVGT
                     TRGEGEMSSLLRALEEFAIYAPLPPMLRAQIPDPAQKQPVGLMGGGLAEALLELKQAGA
                     KNAALLRRIEQELKELGGWVERVSFEPESGYPGVPTGAGRSLDPHLGLRLQDRYLRSEV
                     GWLSAVEANEGTLHVLFLLTMLYHPTTPQVLAIDNVDQSLNPQLARYLLARVQALVLAE
                     PKRPQLLVTTHNPLALDALDLKDDRVRLFIVSRDKRTGATSVERMHHTDALERAKEHNM
                     TLSRLWLSGALGGMPGV"
     gene            4970..5665
                     /locus_tag="SOCE26_RS09840"
                     /old_locus_tag="SOCE26_019690"
     CDS             4970..5665
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SOCE26_RS09840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SOCE26_019690"
                     /product="hypothetical protein"
                     /protein_id="WP_104978357.1"
                     /transl_table=11
                     /translation="MIIGIVCEGSSDFPVLEAVVEAALGDGHEVRYLRPETDALFRPGG
                     WTAVKAWCEEHASWLSDFMTVGNIDLLIIHVDADVRRHVPELKKKKGEPTTQDLCDTIK
                     GWLKLRQSAKGRRVLIVIPAQATEAWLVAAQGGATPDLEKEAKPVTRLVQRKLVSTIGG
                     KPDKSPAVYRDLATPLRSHAAELRGVLRELDHFMGKLEAGRERTGARRSTPSRRAPPPA
                     LPRGSADVL"
     gene            5814..7148
                     /locus_tag="SOCE26_RS09845"
                     /old_locus_tag="SOCE26_019700"
     CDS             5814..7148
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012235696.1"
                     /locus_tag="SOCE26_RS09845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019700"
                     /product="cytochrome P450"
                     /protein_id="WP_104978358.1"
                     /sec_met_domain="p450 (E-value: 3e-67, bitscore: 226.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHLPRGPQGRFLTTYQFIARPYEFLHRCAATYGGVFNVPMYNGD
                     VVMAGSPASVQDVMTAPPETFVPYSTKSIGLLLGPQSLLMLSGERHRRERKLLTPPFHG
                     DRMRAYAAAMADVTARRFAEAARAPRAVAQEVAQAISLDVILRAVFGVEEPARMRAFAR
                     AVVAMGDALTPAMAFLPFLQRELGGFGPYARFRRRVADLEALMRGQIERARAAPGDDIL
                     SLLVSARYDDGSAMSEQAIFDELRTLLFAGHETTAIALAWALDHVHRDPGVLARLLGEI
                     DALGPEPDPERLAALPYLDAVCKEALRLYPVVTEVPRLVAQPFRLGEHELQPGTGVAPC
                     VLLVHHLPELYPEPSRFRPERFLERKFSPFEYLPFGGGSRRCIGAAFALFEMKIVLGTA
                     LSAWQVRLLDERPPRPVRRNVTFGPSGGVPLVLSARARGALRTAA"
     gene            7235..8248
                     /locus_tag="SOCE26_RS09850"
                     /old_locus_tag="SOCE26_019710"
     CDS             7235..8248
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020733850.1"
                     /locus_tag="SOCE26_RS09850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019710"
                     /product="DUF808 domain-containing protein"
                     /protein_id="WP_275937400.1"
                     /transl_table=11
                     /translation="MASATAASGAAADAIDPPHHLDEDLFMAGSSLLALIDDIATVLDD
                     VAILTKVAAKKTAGVLGDDLALNAQQVAGVTAERELPVVFAVAKGSMLNKVILVPAALG
                     ISALIPWAITPLLMIGGAFLCYEGFEKVAHKLVHSRQEDEAHHAELVQALSNPQIDLVA
                     VEKDKIKGAVRTDFILSAEIIAITLGTVAGSPFGTQVAVLSGIALLMTVGVYGLVAGIV
                     KLDDAGLYLSQQGGGMQQAVGRGILKAAPWLMKALSIAGTVAMFLVGGGILTHGIPALH
                     HGIEHLAHGAGAVLGGIVGPLADAVVGIVAGAVVLGIVTAVKKVVGGSKGTEKGAH"
     gene            complement(8592..10004)
                     /locus_tag="SOCE26_RS09855"
                     /old_locus_tag="SOCE26_019720"
     CDS             complement(8592..10004)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="SOCE26_RS09855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019720"
                     /product="MFS transporter"
                     /protein_id="WP_104978359.1"
                     /transl_table=11
                     /translation="MSSPAAKPYAVLAVVAVGTLMAALGSSLINVAVPLVRRDLGADIG
                     AASWVLAAYSLSVSALLLPFGRVGDRHGKGRVYTVGFGVFGVGSALSALAPTLAALVAA
                     RAFQGAGAAMLMANGPALTTAAFPPAQRGRALGLQATATYLGLSLGPSIGGWLAQAAGW
                     HVVFWINVPISVAGALLARSLVWGGAAGAPLAAGRARPFPWASALLFGPALSALLVAVT
                     RGQSWGFWSPRFVFLLVLGVVLAAAFVRVERRSPAPLLSAALLREPAFASGLAAAFVQY
                     AAVYMLMFLLPFYLQGPLAMSAAEAGVVMTVQPAAMALITFGSGWLSDRVGTRGPAVAG
                     IAVLAIGLASVALLGSEPERASVLAALSLVGLGSGLFTSPNNSRIMGAAPREQQGTAAG
                     LLAEARNVGMLCGVAASGAVFAALGGGRPGEGGGAFGAAFQGTILAAAVLAGLGVLASA
                     APPRAATAPPSR"
     gene            complement(10001..11512)
                     /gene="pqqE"
                     /locus_tag="SOCE26_RS09860"
                     /old_locus_tag="SOCE26_019730"
     CDS             complement(10001..11512)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR02109.1"
                     /locus_tag="SOCE26_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019730"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_104978360.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2.2e-18, bitscore:
                     65.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2e-12, bitscore: 46.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.1e-06,
                     bitscore: 27.8, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.8e-20, bitscore: 73.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9.7e-07, bitscore: 28.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.2e-07, bitscore:
                     29.9, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.8e-06, bitscore: 27.5,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIAPGDRLSLASKARLVRDRASGREILLYPERGLALNPVAAAVA
                     ARLDGTRTVAGIAAEVAAAFAAAPPGEVERDVIAFLEALAARGLLERGAATGASPGAAP
                     VAPSPGAAPAAPSPGAAPAAPSPGAAPVAPAPGAAAGAASQHPYTLIAELTYRCPLRCP
                     YCSNPTELAGAAGELSTEVWCRVFAEAAELGVMQLHLTGGEPLARRDLEVLVRRAREVG
                     LYTNLITSGIPLARERLAALREAGLDNLQLSVQDADAERADRIAGYAAYGHKLEVAGWV
                     KAEGLPLTVNVVLHRANIEHVPAIIALAERLGADRLELANTQYLGWALANREALLPTRD
                     QLERAFAIASAARERLLGRMEMVFVTPDYYAAWPRACMDGWARRYLHIAPGGLVLPCHA
                     AHTIPGIHFESVRERSLAWIWREAPSMNRFRGDAWMAPPCQGCERRGVDFGGCRCQAYH
                     LTGDAAATDPACSLAPAHGLVEEARLRAASALKAEPRYLYRSAPR"
     aSDomain        complement(11237..11410)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SOCE26_RS09860_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="2.90E-09"
                     /identifier="RREFam002.1"
                     /label="SOCE26_RS09860"
                     /locus_tag="SOCE26_RS09860"
                     /protein_end="92"
                     /protein_start="34"
                     /score="27.8"
                     /tool="antismash"
                     /translation="LALNPVAAAVAARLDGTRTVAGIAAEVAAAFAAAPPGEVERDVIA
                     FLEALAARGLLER"
     aSDomain        complement(11240..11506)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SOCE26_RS09860_PqqD_RRE.1"
                     /evalue="5.80E-21"
                     /identifier="RREFam006.1"
                     /label="SOCE26_RS09860"
                     /locus_tag="SOCE26_RS09860"
                     /protein_end="91"
                     /protein_start="2"
                     /score="65.0"
                     /tool="antismash"
                     /translation="IAPGDRLSLASKARLVRDRASGREILLYPERGLALNPVAAAVAAR
                     LDGTRTVAGIAAEVAAAFAAAPPGEVERDVIAFLEALAARGLLE"
     gene            complement(11520..12221)
                     /gene="pqqC"
                     /locus_tag="SOCE26_RS09865"
                     /old_locus_tag="SOCE26_019740"
     CDS             complement(11520..12221)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020741452.1"
                     /locus_tag="SOCE26_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019740"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_104978361.1"
                     /sec_met_domain="TIGR02111 (E-value: 8.5e-95, bitscore:
                     315.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDEPLSREAFVARLRDEGARRYHDHHSFHQRMHRGELSRREIQG
                     WVLNRYYYQTRIPIKDALILAKSDDPSFRRRWIHRIVDHDGAQEGEGGLALWLRLAEGV
                     GLDRGEVAGLTKVLPAVRFACDAYVALVRERSLLEAVASSLTEFFAPDLMSRRVVAWEQ
                     HYPWVDKATLDYFRARVTRARVDSTEAIDYVTAHATTRAAQEACVAALITKCDILWAML
                     EAIAAAYPPGA"
     gene            complement(12218..13135)
                     /gene="pqqB"
                     /locus_tag="SOCE26_RS09870"
                     /old_locus_tag="SOCE26_019750"
     CDS             complement(12218..13135)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020741453.1"
                     /locus_tag="SOCE26_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019750"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_104978362.1"
                     /transl_table=11
                     /translation="MRLCVLGSSAGGGLPQWNCACANCVEARRGSARVRPRTQDALALG
                     VNGGSWFLINASPDVHRQIEAFPPLQPRAGRATPIAGVILTNGDLDHTLGLFSLRENTP
                     LAIYATEAVYRGLAEGNTVFRTLQRFPGQTTWRRLELEKPAELAGPDGAPTGVTVVPVA
                     LPGKVPKHLEGLAPPSPEDNIGLWIRDGASGRVAAVATAVGAAGAYVPRLDGADVCFFD
                     GTFWSSDELVRLGLGKARAEDMAHLPIGGDGGSLSLLAGVAARRKIYTHINNTNPILVE
                     GSPERRAVEAAGWEVAVDGLEIDL"
     gene            complement(13158..13298)
                     /locus_tag="SOCE26_RS53625"
                     /old_locus_tag="SOCE26_019760"
     CDS             complement(13158..13298)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SOCE26_RS53625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SOCE26_019760"
                     /product="hypothetical protein"
                     /protein_id="WP_159396806.1"
                     /transl_table=11
                     /translation="MRYEKPDFFEIKMDAEIGSYQSDFDPVPLFTNPAPAERTDDVSGA
                     E"
     misc_feature    complement(13264..13277)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(13392..13410)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.09"
                     /tool="antismash"
     misc_feature    complement(13516..13529)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.35"
                     /tool="antismash"
     misc_feature    13516..13530
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.82"
                     /tool="antismash"
     misc_feature    complement(13520..13533)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.96"
                     /tool="antismash"
     gene            complement(13530..14906)
                     /locus_tag="SOCE26_RS09875"
                     /old_locus_tag="SOCE26_019770"
     CDS             complement(13530..14906)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012233449.1"
                     /locus_tag="SOCE26_RS09875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019770"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_104978363.1"
                     /transl_table=11
                     /translation="MGTTHNELCDKDGKSDWGQLHVTRACCGAGVCRNFAPELLGEVTP
                     AHWAALDGDVGDVGDVGDVARRGPAVLEGTYDEGSFTGVLRQPQSLADLAAARSAVASC
                     PVSALRLTRPAAGVRLGSLGAPFSTWPRRVEDDVWVLGHPSRDNVSATTYFIERPGGGV
                     LVDLPRPSEAMFRFLEEHGGVRWIFLTHRDHVAHHAEFAARFPGSRRVLGAADVTLGGA
                     GHQTDTSDVELKLDGLGPMTLDGAPLTDAELADAELAVLPQPGHTAGSMCLLYRGRFLF
                     TGDHLAYSRRLGQLAAFRLQCWDDWDRQITSVRRLAALAEAGHLRFVWVLPGHGEWKRL
                     DGDGSAAATAAELQRAVAWMERQARGHVPMARFIPWVKGRLRPDSPLARTVCALGGGGP
                     GSDAWLLPRSVRPYLPDHRPEKDRAALLRISLIASVLLGGAAGITWLAARAARTSARWS
                     "
     gene            complement(14977..15819)
                     /locus_tag="SOCE26_RS09880"
                     /old_locus_tag="SOCE26_019780"
     CDS             complement(14977..15819)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020733056.1"
                     /locus_tag="SOCE26_RS09880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019780"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_104978364.1"
                     /transl_table=11
                     /translation="MREPAWVVWLRRAVLAGLAVFTVVPLYVMVTSALKPLRDVQGPFT
                     WLPTEVTLQPFFDMWRTVPLARYFVNSAVVAAASTVFSVALAILAGYAVSRYRFWGRRA
                     FLTTVLSTQMFPGILFLLPLFLIFVQIERTLGLELHGTRLGLIITYLTFSLPFSIWLIA
                     GYFDTIPRELDEAALVDGARPLTALLRVVLPVAKPGVVAVAIYAFMTAWGEVLFASVLT
                     DDDGRTLAVGLQGYATQSNIYWNQVMAASVVVSVPVVTGFLVLQRYLVQGLTAGAVKT"
     gene            complement(15812..16810)
                     /locus_tag="SOCE26_RS09885"
                     /old_locus_tag="SOCE26_019790"
     CDS             complement(15812..16810)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020733055.1"
                     /locus_tag="SOCE26_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019790"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_104978365.1"
                     /transl_table=11
                     /translation="MGGGTSTEGAGRGAPPLAGAPAAARPRKAPRRRWQSRVLPYVFLL
                     PALVAELAVHLVPMFVGAGMSFLQLTQRFIRNWAKAPVVGLANYRIAIDVSSPVGENLL
                     RSFFITVAFSLLVVAGSWLFGTAAAVALQKPFPGRTALRTLFLVPFAMPIFTGVITWSF
                     MLQRDTGIVNTVLVDQLGLVDERPFWLLGPNSFASLVVVAIWRTWPFAFLTVTAGLQAI
                     PSDLYEAASVDGAGPWTRFRSITLPMLRPVNQVLLLVLFLWSFNDFTTPFTLFGRSAPP
                     EAGVIAIHIYQASFITWNFGLGSAMSVLLVGFLLLVTTGYLLISGRSARHA"
     gene            complement(16810..18183)
                     /locus_tag="SOCE26_RS09890"
                     /old_locus_tag="SOCE26_019800"
     CDS             complement(16810..18183)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012233399.1"
                     /locus_tag="SOCE26_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019800"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_104978366.1"
                     /transl_table=11
                     /translation="MKSRILDAVAACALLALGTAACGKSGGDAPSASPGSSAQGAQGAR
                     GAPAAEAVTLTYWASNQAPSVEDDRKILQPELDKFEKQTGIKVKLEVISWSDLLNRILA
                     ATSSGKGPDVLNIGNSWSASLQATGAFLPFDDAALAKIGGKDRFVATTLSATGAAGQPP
                     AAVPLYGLAYGLFYNKKMFADAGIEKPPANWGEFITVAKKLTDAKGGRYGVAIMGASYS
                     ENAHFAFMFGRQHGAAIFEGKQPRFDAPEMVAGVKQYIDLLSVHKVVNPSNAEYVNDTQ
                     MLKEFTSGKAAMLMIQSYAQAAIEQNGMARDAYGVAPVPMPDPLPAGGKAVNSHVAGIN
                     IAVFEESKNRDAALKFVAFMTSPEEQKILNGAFGSLPVVSEAYADERFKSANTQVFQKV
                     LAETAESMPMIEETAQFETLVGTAMRDLLAEAASGKAVTDASIRGKLTAANQQMASGK"
     gene            complement(18500..19351)
                     /locus_tag="SOCE26_RS09895"
                     /old_locus_tag="SOCE26_019810"
     CDS             complement(18500..19351)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (29-264). E-value:
                     3.6e-35. Score: 113.7. Matches aSDomain:
                     nrpspksdomains_SOCE26_RS09895_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012239274.1"
                     /locus_tag="SOCE26_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019810"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_104978367.1"
                     /sec_met_domain="PF00561 (E-value: 7.1e-31, bitscore:
                     107.0, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.6e-20, bitscore:
                     71.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVQAGDTRLFFDVEGSKLVPDGPAMRERPTVLLLHGGPGFDHTE
                     FRPFGSALADVAQVIYLDHRGSGRSDRSGPERWNLDTWADDVRAFCDALDIERPVVLGS
                     SFGGMVAQAYAARHPDHPAKLILVSTTARLRLDRMLVMFERLGGARAAGVARRFFADPR
                     ATFPEYIDVCFPLYRQSPPEQGAVERAVLHLDVGGYFVAGEMQTFDLRADLARVRCPTL
                     VLSGDLDPFATTEDARELAAALPPELVQIRRFPSAGHAVLDDARAEALAAIRAFLGAAR
                     AA"
     aSDomain        complement(18560..19264)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SOCE26_RS09895_Abhydrolase_1.1"
                     /evalue="3.60E-35"
                     /label="SOCE26_RS09895_Abhydrolase_1.1"
                     /locus_tag="SOCE26_RS09895"
                     /protein_end="264"
                     /protein_start="29"
                     /score="113.7"
                     /tool="antismash"
                     /translation="PTVLLLHGGPGFDHTEFRPFGSALADVAQVIYLDHRGSGRSDRSG
                     PERWNLDTWADDVRAFCDALDIERPVVLGSSFGGMVAQAYAARHPDHPAKLILVSTTAR
                     LRLDRMLVMFERLGGARAAGVARRFFADPRATFPEYIDVCFPLYRQSPPEQGAVERAVL
                     HLDVGGYFVAGEMQTFDLRADLARVRCPTLVLSGDLDPFATTEDARELAAALPPELVQI
                     RRFPSAGHAVLDD"
     CDS_motif       complement(19001..19051)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SOCE26_RS09895_0001"
                     /evalue="2.00E-03"
                     /label="NRPS-te1"
                     /locus_tag="SOCE26_RS09895"
                     /protein_end="117"
                     /protein_start="100"
                     /score="10.7"
                     /tool="antismash"
                     /translation="VLGSSFGGMVAQAYAAR"
     misc_feature    complement(19314..19323)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     misc_feature    complement(19356..19372)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.69"
                     /tool="antismash"
     gene            complement(19488..20456)
                     /locus_tag="SOCE26_RS09900"
                     /old_locus_tag="SOCE26_019820"
     CDS             complement(19488..20456)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03557.1"
                     /locus_tag="SOCE26_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019820"
                     /product="TIGR03885 family FMN-dependent LLM class
                     oxidoreductase"
                     /protein_id="WP_104978368.1"
                     /transl_table=11
                     /translation="MRKLAIGYHASHEQLAPSALLRHVRHAEQAGFAGAMCSDHFLPWG
                     EKQGQSGFAWAWLGAALEATSLSFGTVCAPGYRYHPAVIAQAAATLAEMYPGRFWLSIG
                     SGEALNEHITGEKWPDHAERTARLEECAEVIRALWRGEEVTHRGRVVVDGAKLYTRPAA
                     PPRLLGAAISAATAARVGRWADGLITVSQGRDQLREVVRRFREGGGEGKPMVLQVKIAY
                     DPDERVALREAHEQWRTNVLPPRLLASLTVPEHFDAAASFVRPEDVAAQVHVSADPARH
                     AAWLREHAELGFDAIYVHNVTSNQQAFIDTFGERVLPALLK"
     gene            complement(20585..21550)
                     /locus_tag="SOCE26_RS09905"
                     /old_locus_tag="SOCE26_019830"
     CDS             complement(20585..21550)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020733882.1"
                     /locus_tag="SOCE26_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SOCE26_019830"
                     /product="M28 family peptidase"
                     /protein_id="WP_104978369.1"
                     /transl_table=11
                     /translation="MTSTRDPSRVFAGICAAFALASASCAVEDLSEPAADEIHGSLVGV
                     DTVMTIEPEFLEARLRELSGAATATVGGRAVVIRERGSAGGRALARGWLREQYEALGFT
                     VEEHAYDSGFERGVNVVAEKAGADPSRVLIVSAHYDSTNNAGADDDGSGVVSSLAIARA
                     LAEAPLRISLRVVAFDQEESGLLGSNAYARMLARAGQMEQVVGVIDLEMTAYDANDDGK
                     YHVIHCNENTSAELADRVEAAAVRGDLGLTRVDACTDRSDHAAFWRYGKPAVAVSQAFF
                     GGDGNPCYHARCDTVDRLNWDYMRRLTQAAGLAAADILLE"
     gene            complement(21722..21940)
                     /locus_tag="SOCE26_RS56665"
                     /old_locus_tag="SOCE26_019840"
     CDS             complement(21722..21940)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SOCE26_RS56665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SOCE26_019840"
                     /product="hypothetical protein"
                     /protein_id="WP_234024103.1"
                     /transl_table=11
                     /translation="MRILASAIDTIDTCRRGQLARRDGAPREAAAAPSAPGAPAAPAAP
                     SAPAAPSAPVDTPAPSFPETLHRPGGG"
ORIGIN
        1 gccgcgttct accggaactt cttcgggcag tggctcgggc tgcgcgcgct ccccagccac
       61 aacgtcgatg cgtcgctgtt cccggtctgg agcggcgaca tgaaaggcgc gatgatcgcc
      121 caggccagcg cctatctgtc cggcttcacg accggcgagc ggaggtggtc cgagctcctc
      181 acggcgcctc acccggagag ccccgagctc gccccgctct acgcgaacga tccggagggc
      241 gtgcgcggcg ggttcctcac gctccccgcg ttcctcacgc tctcgtcgca cgacgatcgg
      301 acctcgccca cgtcgcgcgc gaagacgatc ctggtgcagc tcttctgcgt cgacatcgcg
      361 ccgcccgccg acatggtgat ccccgatctc agcgtcgcgg gcggcgacga gatccccgcc
      421 gagaacgttc gcaagaagct cgagaagcac cgcgagtcgc ccgattgcgc ggtctgccac
      481 aacgtgctcg accccatcgg gctgagcctg gagcacttcg acgcgatcgg cgcctaccgg
      541 accacgtacc cgaacggcga cgaggtcgac gcgtcgggca cgtacggaga ggcggagttc
      601 caggacctga caggcctcct gccggagctc cggaaggaca cccggctcgg gacctgccct
      661 cccaggcagc tcttcgcgta cgcgctgcgc cgcagcccgg ccggcgagga catgcacgtc
      721 atccaggaga tcgccgcggg ctggggcggc gggacgatcg ccgatctggt gaagcgggtg
      781 gtggcgagcg actcgttccg cctgcgccac gcgaagaggg gggcaccgtg aggcggcgcg
      841 cgctgtctgc ctgcgagtct ccggacgagc ttcggcgccg gtctccgtgc gagttcccgc
      901 accagcttcc tcatcagttt ccgcaccggt tcaggcacga aggagcgatg tgcacatgaa
      961 acgctggatc acacgcagga acctgctcag gggcgcgggg gtgtgcctgg cgctgccgtg
     1021 gctcgagagc ctgtcgccgc ggagcgcccg cgcgggggac gccggcaccc cgaagcgctt
     1081 cctgctctgc acgttcccga acggggcgcc ccaccactgg tgggagacgg cgcctgcgtt
     1141 cggcaagacg ctgacgggcg ccgatttcaa gctgccgagg gtgctcgagc acttcgcgcc
     1201 ggtgaagtcg aagatgctca tgataagccg cctcggcaac tacacgtgga acaaggagct
     1261 gagcccgtac gtcgagccgt cccactcgcg cctcacggcc gcgctgtcga cgtgcgtcga
     1321 cgccgatcag ctggggagag accaggggca ggacctcggg gcgtgggtgg gcaacggcgt
     1381 ctcggtcgat cagctcatcg tgcagaagat cggcccggag caggcgaccc gcatcccgtc
     1441 gctgcagacg gggctcgggg tcaaaccagg ctatttcgac gagcggagct acgcttacaa
     1501 ccaggcgatc tcctggaaga gcccgcgcga gccgctgaag cgctcggtca acccgagggc
     1561 ggtgttcgac gcgctggtcg gcgcgggcgc ggcgagcgcg gcgcccgtcc ccgggcagac
     1621 cgaagggcag gccaggatcg aggcggcgcg gcgcgccgcg gccgagaaga gcgtgatcga
     1681 cgccgtgctc gcggacgcga acgcgctgaa gggccgggtc ggcgcggaag accgcaggat
     1741 cgtggagcag tacctcgacg cgctgcggga gatcgagaag aacgcgaccc gcgtcgcggc
     1801 gacgatgaac ccggcgaacc tcggctgcgc gccgatcccc gagcccggcg tggtgcccga
     1861 gccgccgggc caggcggagg ggctgaacga gaacgacagc acggaagccg gcgagtaccg
     1921 gcacgaggat cacgcgaacg tgatgaccga cctgctcgtc atggccatcc agtgcgacgt
     1981 gacgcgcgtc gtcacccaca tgctcgacga cgcgcgctcc gagttcgaat accggtgcat
     2041 cccggaggag gtccgcgcga aggtcggcct cgaataccgg gcagagagca gccttcattt
     2101 ccacgcctcc cagcatggcg ccggcaacct ggaccgcgcg atcgaggacg gccgctaccg
     2161 gatcatccag ccgagcaacg cggagttcgc ggcgatcaac tgctggctcg gccagaagac
     2221 agcagagctc gcgcagcggc tcgacgcgat ccccgagggc gacgggacgg tgctcgatca
     2281 ctcggtcatg gtctacatga gcgagatgcg cacacacgac cacgacgcgt acgatctgcc
     2341 catcgtcctc ctgggcggcg gcggcgtgtt cctgaacgac gcccacgtcg cgtacgacgc
     2401 cctcggcagc gaccgccagc tgcgcgatct ctggttcacg atcatgaacc agtactacgg
     2461 cctggaggtc gcgtcgttcg gcgacgatac gcgcggcgag ccgaacgcgc tgctcgagga
     2521 gatcctgcgg tagcccgacg gggcgaccgt ccgaggggag ccgcgttatg ctcggcgcgc
     2581 gccatgcccg acgacgagct cgtctttgcc tccatgcccg ccgcgctcat ctccttcgcc
     2641 tgctcgcgcg gcgtcccgca ggacgatctc ctccgcgccg ccggcgtctc ggccgaggcg
     2701 ctcgccgcgc ccgacgagct cgtgccgtac gggtcgctcc tcgggctctg ggagctcctg
     2761 ctccggcgct tcccgggcga gccgctcggg ctttcgtacg cgcagtggat cccggtgtcg
     2821 gtcgtcggca tcgtggggca cgccatccgc cacagcgaga cgttgcggca gggcgtcgcg
     2881 gtgtatgccc ggttctgccg gctcatggac ccgcacctcc gcctcgccgt ggaggagcac
     2941 ggcgaggtcg tccacctcgc gctcgagcac gagccgcgcg tcgtcgccat ggccgagccg
     3001 atggagatga tgatcgcggc gctcgcgcgc ttcatcgcgc tctacctcga cggcgccgcg
     3061 cggccggccg aggcccggtt ccgccacgct cgccggcacc cgccggcgcg ctacgaggag
     3121 gcgatcggcg tcccggcccg cttcgaggcg gcctccacgt gcctcgtcta cgacgcgcgt
     3181 ttcctcgacg cgcccgtcgt gggagcggac ccgtcggtcc acgactacct cgtgcgccag
     3241 gccgagcggc tcctcgccgc gcgcgcggcc ccggccggcg ccgcgccgct cgacgcccgc
     3301 gtgcgcgcgc gcatcgacga gcggatcgag cgcggcgagg tggagcagga gcagatcgcg
     3361 cgcgcgctgg gcatgagcac gcgctcgctc cagcgcgccc tcaaggatct cggcacgtcg
     3421 ttcacggccc agctcgacga ggtccggcgg gcgagggcgc tcgagctcgt ccgccgccgc
     3481 gacgtgacgc tccaggagat cgcgttcctg ctcggctacg gggagccgcg ccacttctac
     3541 cggagcttcc gccgctggac cgggagcacg ccgggcgagt accggcgcgc caacgcgcgc
     3601 tagcgccgag caccggcgca cccacgtgtg gtagcgccgg cgcgcgatgt ctcccgggga
     3661 ggcgcgccgc aaacggcgcc cggcggcgag ccctttgcga taaggtgggc cgcatgcttc
     3721 gcagggtcca catccggggg ttcaagaccg cgatcgacgc ggtcctggac ctcgggcggc
     3781 tcaacgtgtt cgtggggccg aacggagcgg gcaagagcaa cctgctcgag gcgatcgcgg
     3841 tgctcggctg cgccgcgtcc gggcgggtgg actacgacgc cttccgggcg cgcgggatcc
     3901 ggcccgggaa acctggcctg ctcaagaccg cgctgagctc cgagaagcgg gccgcgcgca
     3961 ccatcctgct cgaggcggtg tccgacagca cgcgttacca ggtggtcctc ggtgattcgg
     4021 cgctcgggcg cggcgcctcg acggggagcg cggcgtggcg gttcgacaag gagaccttct
     4081 ccgagggaga gcaggaggtc ggctcccgct cgaagggcga gggctacctc gtccacgcgg
     4141 acggggcgag acaggcgatc acggcgcggc tcgaccgcgg gatcgcgccg ctcgtgggca
     4201 cgacgcgcgg ggaaggggag atgtcgtcgc tgctccgcgc gctcgaggag ttcgcgatct
     4261 acgcgccgct gccgccgatg ctgcgcgccc agatcccgga tcccgcgcag aagcagccgg
     4321 tcggcctcat ggggggcggg ctggccgaag cgctgctcga gctgaagcaa gccggggcca
     4381 agaacgcggc gctgctgcgc cggatcgagc aggagctcaa ggagctcggc ggctgggtag
     4441 agcgggtgtc cttcgagccc gagagcggct atccgggcgt gccgacgggc gcggggagga
     4501 gcctcgatcc acacctcggc ctccgcttgc aagatcgtta tctccggtcc gaggtgggct
     4561 ggctgtccgc ggtcgaggcc aacgaaggga cactccatgt cctcttcctc ctcacgatgc
     4621 tctaccaccc gacgacgccg caggtcctcg cgatcgacaa cgtcgatcag tcgctgaacc
     4681 cgcagctcgc gcgctacctc ctcgcgcgcg tgcaggcgct cgtcctcgcc gagccgaagc
     4741 ggccgcagct gctcgtcacg acgcacaacc cgctcgccct cgacgcgctg gacctgaagg
     4801 acgaccgggt gcgcctgttc atcgtgagcc gcgacaagag gaccggcgcg acctcggtgg
     4861 agcggatgca ccacaccgac gccctcgagc gcgcgaagga gcacaacatg acgctgtcgc
     4921 gcctctggct ctccggcgcg ctgggcggga tgccgggggt ctgagcgccg tgatcatcgg
     4981 gatcgtatgc gaggggagct ccgactttcc cgttctcgag gcggtggtgg aggccgcgct
     5041 cggagacggc cacgaggtgc gttatctgcg gcccgagacc gacgcgctct tcaggccggg
     5101 cggatggacc gcggtcaagg cgtggtgcga ggaacacgcg tcatggctgt cggacttcat
     5161 gacggtgggc aatatcgatc tgttgatcat ccacgtcgac gccgacgtcc gtcggcacgt
     5221 ccctgagctc aagaagaaga agggagagcc cacgacgcag gacctctgcg acacgatcaa
     5281 ggggtggctg aagctccgtc agagcgcgaa ggggaggcgg gtgctcatcg tcatcccggc
     5341 gcaagccacg gaggcctggc tcgtggccgc ccaggggggc gcgacgccgg acctggagaa
     5401 ggaggcgaag ccggtcacaa ggctcgtcca gcgaaagctg gtgagcacga tcggcgggaa
     5461 gcccgacaag agccccgccg tgtacaggga cctcgcgacg ccgctcagga gccacgcggc
     5521 cgagctgcgg ggcgtgctcc gggagctgga tcacttcatg gggaagctgg aggcgggccg
     5581 ggagcggacg ggggccaggc ggagcacgcc gtcgcgccgc gcgccgccgc cggcgctccc
     5641 tcggggcagc gcggacgtcc tgtagcggcg ctggtccagg gtcgcctggc gcgatccgtc
     5701 gcaacgttgg cgcccgccgc cgctgccgcg gcgccgcgcc ggacccatcg ttggcatcgg
     5761 tcccggcgcc gcgccgcgcg cctgccggga tcgagctcct gccgaggtgc gccatgagcc
     5821 atttgccccg aggcccgcag ggccgattcc tgacgactta ccagttcatc gcccgtccgt
     5881 acgagttcct gcaccgctgc gccgccacct acggcggcgt gttcaacgtc ccgatgtaca
     5941 acggcgacgt cgtgatggcc ggcagccccg cgtcggtgca ggacgtgatg accgcgccgc
     6001 cggagacgtt cgtgccgtat tccaccaagt cgatcggcct cctcctgggg ccgcagtcgc
     6061 tcctgatgct ctcgggcgag cgccaccggc gggagcggaa gctgctgacg ccgccgttcc
     6121 acggcgaccg catgcgcgcc tatgcggcgg cgatggcgga cgtcaccgcc cgccgcttcg
     6181 ccgaggcggc gcgtgcgccc cgcgccgtcg cgcaggaggt cgcgcaggcg atctcgctcg
     6241 acgtcatcct gcgcgccgtg ttcggggtgg aggagcccgc ccggatgcgc gcgttcgcgc
     6301 gcgcggtcgt ggcgatgggc gacgcgttga ccccggcgat ggccttcctg ccgttcctgc
     6361 agcgggagct cggcggcttc ggcccgtacg cgcgcttccg ccggcgcgtc gccgacctgg
     6421 aggcgctgat gcgcgggcag atcgagcggg cgcgcgcggc gccgggggac gacatcctga
     6481 gcctcctggt ctcggcccgc tacgacgacg ggtcggccat gagcgagcag gcgatcttcg
     6541 acgagctccg gacgttgctc ttcgccgggc acgagaccac ggcgatcgcc ctcgcgtggg
     6601 ccctggatca cgttcaccgc gaccccggcg tcctcgcgcg gctgctgggc gagatcgacg
     6661 ccctcggccc ggagccggat ccggagcgcc tggccgcgct gccgtacctg gacgcggtgt
     6721 gcaaggaggc gctgcgcctc tacccggtcg tgaccgaggt cccgcgcctc gtggcgcagc
     6781 cgttccgcct cggcgagcac gagctccagc cgggaacggg ggtggcgccc tgcgtcctgc
     6841 tcgtgcacca cctgcccgag ctttaccccg agccgtcccg gttccggccc gagcgcttcc
     6901 tggagcgcaa gttctcgccg ttcgagtacc tgccgttcgg cggcggctcc cgccgctgca
     6961 tcggcgcggc gttcgcgctg ttcgagatga agatcgtgct cggcacggcg ctgtcggcgt
     7021 ggcaggtccg cctgctcgac gagcggccgc cccgccccgt gcggcgcaac gtcacgttcg
     7081 gcccgtcggg cggcgtcccg ctcgtcctga gcgcccgcgc ccgcggcgcc ctccgcaccg
     7141 ccgcctagcc gcgggaggcc ccgcagcgcg gggaaggcgc gcggatcgac gtgcacgtgc
     7201 agatcttcga cggccgcggc cggcgcccgc tacgatggcg tccgcgacgg ctgccagcgg
     7261 cgccgccgcg gacgcgatcg acccccccca tcatctcgac gaggatctct tcatggccgg
     7321 aagcagcctg ctcgccctga tcgacgacat cgccaccgtg ctggacgacg tggccatcct
     7381 gacgaaggtg gccgccaaga agacggccgg cgtgctgggc gatgacctgg cgctcaacgc
     7441 gcagcaggtg gccggtgtca ccgccgagcg cgagcttccc gtcgtgttcg cggtggccaa
     7501 gggctcgatg ctcaacaagg tcatcctggt gccggcggcg ctggggatca gcgcgctgat
     7561 cccctgggcg atcacgccgc tgctcatgat cggcggggcc ttcctgtgtt acgagggctt
     7621 cgagaaggtc gcccacaagc tggtgcacag ccggcaggag gacgaggccc accacgccga
     7681 gctggtgcag gcgctgtcga acccgcagat cgatctcgtg gccgtcgaga aggacaagat
     7741 caagggcgcg gtgcgcaccg atttcatcct gtcggccgag atcatcgcga tcacgctggg
     7801 cacggtggcg gggtcgccgt tcggcacgca ggtggccgtg ctgagcggca tcgccctgct
     7861 catgacggtg ggcgtgtacg ggctcgtggc gggcatcgtg aagctcgacg atgcggggct
     7921 ctacctgagc cagcagggcg gggggatgca gcaggcggtg ggccgtggaa ttttgaaggc
     7981 ggcgccgtgg ctgatgaagg cgctgtcgat cgcggggacg gtggcgatgt tcctggtggg
     8041 aggggggatc ctcacgcatg ggattccggc gctgcatcat gggatcgagc accttgcgca
     8101 tggcgcgggg gcggtgctcg gggggatcgt ggggcccttg gccgatgccg tggtggggat
     8161 cgtggcgggg gcggtggtgc tggggatcgt gaccgcggtg aagaaagtcg tgggcggctc
     8221 gaaggggacg gagaagggcg cccactgagc cgacggcggt gaggacgcag cggtcgtctt
     8281 tcgtccctcg tctttcgtct ttcgtctttc gtctttcgtc tctcgtgaac gtcctcgtga
     8341 acgtgaacgt gaacgtgatc gtgatcgctc ccgaacgagc cgttcgcacc gtttgcgggc
     8401 gatcgcatgg ctgcacgacc gcgcacgtga gacgcgcacg cggaatcgtt cacgttcacg
     8461 ttcacgagga cgttcacgag agacgttcac gagagacgag agacgttcac gagagacgtt
     8521 cacgagagac gagagacgag agacgagaga cgaaagacga acggcagagc caagcggctc
     8581 cgcgccggcg tttagcgcga cgggggcgcc gtcgcggcgc gggggggcgc cgcgctcgcg
     8641 aggacgccca gccccgccag gaccgccgcg gcaaggatcg tcccctgaaa cgccgccccg
     8701 aacgcccctc ccccctcgcc cggcctcccc cctcccagcg cggcgaacac cgcccccgac
     8761 gccgccaccc cgcacagcat ccccacgttg cgcgcctccg cgagcaagcc cgcggcggtc
     8821 ccctgctgct cgcgcggcgc agcccccatg atgcggctgt tgttcggcga cgtgaacagc
     8881 cccgagccga gccccaccag cgacagcgcc gcgagcacgc tcgcgcgctc cggctcggac
     8941 ccgagcaggg ccacgctcgc gagcccgatc gcgagcaccg cgatgcccgc gaccgccggc
     9001 ccgcgcgtgc cgacccgatc cgagagccac ccgctcccga aggtgatcaa cgccatcgcc
     9061 gccggctgca ccgtcatcac gacgcccgcc tccgccgcgc tcatcgcgag cggaccctga
     9121 aggtagaacg gcaggaggaa catcagcatg tacaccgccg cgtactggac gaacgccgcg
     9181 gcgagcccac tcgcgaacgc cggctcccgg aggagcgcgg ccgagagcag cggcgcgggg
     9241 ctcctccgct ccacccgcac gaacgccgcc gcgaggacca cgccgaggac gagcaggaag
     9301 acgaaccggg ggctccagaa cccccagctc tggccgcgcg tcacggcgac gagcagcgcg
     9361 ctgagcgccg ggccgaacag gagcgcgctc gcccacggga aggggcgcgc gcggccggcg
     9421 gcgagggggg cgccggccgc gccgccccac acgagcgacc gcgcgagcag cgcgcccgcg
     9481 accgagatcg gtacgttgat ccagaagacc acgtgccagc cggcggcctg cgcgagccag
     9541 ccgccgatcg acgggcccag ggacaggccg aggtacgtcg ccgtcgcctg caggccgagc
     9601 gcgcggccgc gctgcgccgg cgggaacgcg gcggtggtca gcgccgggcc gttcgccatc
     9661 aacatcgccg ctcccgcgcc ctggaacgcg cgcgccgcga cgagcgccgc gagcgtgggc
     9721 gcgagcgccg agagcgccga gcccaccccg aagaccccga agcccaccgt gtacaccctc
     9781 cccttgccgt gacggtcgcc gacgcggccg aagggcagga gcagcgcgct cacggagagc
     9841 gagtaggccg cgagcaccca gctcgccgcg ccgatgtcgg ccccgagatc ccggcgcacg
     9901 agcggcaccg cgacgttgat caggctgctg ccgagcgcgg ccatcaacgt gccgaccgcg
     9961 accacggcga gcacggcgta cggcttcgcc gcgggagagc tcaccgcggg gcgctgcggt
    10021 agaggtaacg cggctcggcc ttcagcgcgg acgcggcgcg gagccgggcc tcctcgacga
    10081 gcccgtgcgc cggcgcgagc gagcaggccg gatcggtcgc ggcggcgtca ccggtgaggt
    10141 ggtaggcctg gcagcggcag cccccgaagt cgaccccgcg gcgctcgcag ccctggcagg
    10201 gcggcgccat ccacgcgtcg ccgcggaagc ggttcatgct gggcgcctcg cgccagatcc
    10261 aggcgagcga acgctcccgg acgctctcga agtggatccc cgggatcgtg tgcgcggcgt
    10321 ggcacggcag caccaggccg cccggcgcga tgtgcaggta acggcgcgcc cagccgtcca
    10381 tacacgcccg cggccacgcc gcgtagtagt ccggcgtgac gaagaccatc tccatccggc
    10441 cgagcagccg ctcgcgcgcc gccgaggcga tcgcgaacgc ccgctcgagc tgatcccgcg
    10501 tcggcagcag cgcctcgcgg ttcgcgagcg cccagccgag gtactgcgtg ttggcgagct
    10561 cgagccggtc ggccccgagc cgctcggcga gcgcgatgat cgccgggacg tgctcgatgt
    10621 tcgcccggtg cagcaccacg ttcaccgtga gcggcagacc ctcggccttc acccacccgg
    10681 ccacctcgag cttgtggcca tacgccgcat aaccggcgat ccggtcggcg cgctccgcgt
    10741 cggcgtcctg gacgctgagc tgcaggttgt cgagccccgc ctcccgcagc gccgcgaggc
    10801 gctcccgcgc gagcgggatc ccggaggtga tcaggttcgt gtacagcccc acttcccgcg
    10861 cgcggcggac gagcacctcg aggtcgcgcc gggcgagcgg ctcgccgccg gtgaggtgga
    10921 gctgcatcac cccgagctcg gccgcctcgg cgaagacgcg gcaccacact tccgtcgaga
    10981 gctcgccggc cgcgccggcg agctcggtcg ggttcgagca gtacgggcag cgcagcgggc
    11041 agcggtaggt gagctccgcg atgagcgtgt aggggtgctg tgaggccgcg cccgccgccg
    11101 cgccaggcgc tggcgcgaca ggcgccgccc cgggggaggg cgcggcaggc gccgccccgg
    11161 gggagggcgc ggcaggcgcg gccccggggg agggcgcgac aggcgccgcc ccgggcgacg
    11221 cgcctgtcgc cgcgccgcgc tcgagcaacc cgcgcgcggc gagcgcctcc aggaaagcga
    11281 tcacgtcgcg ctccacctcg ccgggcgggg cggcggcgaa ggcggccgcg acctcggcgg
    11341 cgatcccggc cacggtgcgc gtcccgtcga ggcgcgcggc gaccgccgcc gccaccgggt
    11401 tcagcgcgag gccgcgctcc gggtagagca ggatctcccg gcccgaggcg cggtcgcgca
    11461 cgagccgcgc cttgctcgcg aggctcaacc ggtcgccggg cgcgatgttc atccccgcgt
    11521 cacgccccgg gcgggtaggc cgccgcgatg gcctcgagca tcgcccagag gatgtcgcac
    11581 ttcgtgatga gcgccgcgac gcacgcctcc tgcgcggccc gcgtcgtcgc gtgcgccgtc
    11641 acgtagtcga tcgcctcggt cgagtcgacc cgggcgcgcg tcacccgcgc gcggaagtag
    11701 tcgagcgtcg ccttgtcgac ccagggatag tgctgctccc aggcgacgac gcgccgggac
    11761 atgaggtccg gcgcgaagaa ctccgtcagc gacgaggcca ccgcctcgag caggctgcgc
    11821 tcgcgcacca gcgccacgta ggcgtcgcag gcgaagcgca ccgcgggcag caccttcgtc
    11881 aggcccgcga cctcgccgcg gtcgagcccc acaccctcgg cgagccgcag ccacagcgcg
    11941 agcccgccct cgccctcctg cgcgccgtcg tggtcgacga tgcggtggat ccagcgccgc
    12001 cggaacgacg ggtcgtcgct cttcgcgagg atcagcgcgt ccttgatggg gatccgcgtc
    12061 tggtaatagt accggttcag cacccagccc tggatctcgc ggcgcgagag ctcgccgcgg
    12121 tgcatccgct ggtggaagga atggtgatcg tggtagcgcc gggcgccctc gtcgcgcagc
    12181 cgcgcgacga acgcctcccg cgagagcggc tcgtcgttca caggtcgatt tccaggccgt
    12241 caacggccac ttcccagccc gccgcctcga cggcgcgccg ctcgggcgag ccctcgacca
    12301 ggatcgggtt ggtgttgttg atgtgggtgt agatcttccg tcgcgcggcg acgcccgcga
    12361 gcagcgagag gctgccgccg tcgccgccga tcggcaggtg cgccatgtcc tccgcgcgcg
    12421 ccttgccgag cccgaggcgc acgagctcgt cgctcgacca gaaggtgccg tcgaagaagc
    12481 agacgtccgc cccgtcgagg cgcgggacgt aggcgccggc cgccccgacc gccgtcgcga
    12541 cggcggcgac acgcccgctc gcgccgtcgc ggatccagag gccgatgttg tcctccggcg
    12601 acggcggggc gaggccctcg aggtgcttcg gcaccttgcc cggcaacgcg accgggacga
    12661 ccgtcacgcc cgtgggcgcg ccgtccggcc cggcgagctc cgcgggcttc tccagctcca
    12721 ggcgccgcca cgtcgtctgc ccggggaagc gctggagcgt gcggaagacg gtgttgccct
    12781 cggcgaggcc gcggtacacc gcctcggtcg cgtagatcgc gagcggcgtg ttctcgcgca
    12841 acgagaagag gcccagcgtg tggtcgaggt cgccgttcgt gaggatcacc cccgcgatcg
    12901 gcgtggcccg cccagcgcgc ggttgcagcg gcgggaaggc ctcgatctgc cggtgcacgt
    12961 cgggggaggc gttgatgagg aaccagctgc ccccgttcac cccgagcgcg agcgcgtcct
    13021 gggtgcgggg gcggacgcgc gccgagccgc ggcgcgcctc aacgcagttc gcgcaggcgc
    13081 agttccattg cgggagcccg ccgccggcgg acgagcccag gacgcagagg cgcattccgc
    13141 cggtcgctcc cgagcgccta ctccgccccg ctcacgtcgt cggtacgctc cgccggcgcc
    13201 gggttcgtga acagcgggac aggatcgaag tcgctctggt aagagccgat ctccgcatcc
    13261 atcttgatct cgaagaagtc aggcttttcg tagcgcatcg gtgtatcctg cctttccttg
    13321 gtggccaacg aaggtatagc tcggtcgagt gtagacgcca caccgtcgct ccacaaaccc
    13381 tttgaccaaa acgcatcctg tcgggaattt ccatcaggag accccgtagc ggggtccgtg
    13441 cgggccgcag cgtaagtggt tcagcgcgag gcgtctccct gcatgagcag cgtggcgatc
    13501 ccgtcgcgcg ctccttttct tctaatgatt cacgaccacc ttgcggacgt gcgcgcagcg
    13561 cgcgctgcga gccaggtgat gccggccgcg ccgccgagca aaacgctcgc gatcagcgag
    13621 atgcggagca acgcggcgcg atctttttca ggccggtgat cgggcagata agggcggacg
    13681 gagcgcggca gcagccacgc gtcgctcccg gggccgccgc cgccgagcgc gcacaccgtg
    13741 cgggcgaggg ggctgtcagg cctcaggcgg cccttcaccc acgggatgaa ccgggccatg
    13801 gggacatggc cgcgggcctg ccgctccatc caggcgacgg cgcgctggag ctcggcggcc
    13861 gtcgcggccg cgctgccgtc gccgtcgagg cgcttccatt cgccgtggcc gggcagcacc
    13921 cacacgaagc ggaggtggcc agcctcggcg agggcggcca ggcggcgcac cgaggtgatc
    13981 tgacgatccc agtcgtccca gcactggagc cggaacgccg cgagctggcc gaggcgacgg
    14041 gagtaggcga ggtggtcgcc ggtgaacagg aatcggcccc ggtaaagcaa gcacatcgag
    14101 cccgcggtgt ggcccggctg ggggagcacg gcgagctcgg cgtcggcgag ctcggcgtcg
    14161 gtgaggggcg cgccgtcgag ggtcatcggc ccgaggccgt cgagcttgag ctccacgtcg
    14221 gacgtgtcgg tctggtgccc ggcgccgccc agggtcacgt ccgcggcgcc gagcacgcgg
    14281 cggctcccgg ggaagcgggc cgcgaactcg gcgtggtggg cgacgtggtc gcggtgcgtg
    14341 aggaagatcc agcggacgcc gccgtgctcc tcgaggaagc ggaacatcgc ctcgctcggc
    14401 ctgggtagat cgacgagcac gccgccgccg gggcgctcga tgaagtaggt ggtggcgctg
    14461 acgttgtcgc gcgaggggtg gccgaggacc cagacgtcgt cctcgacgcg ccgcggccag
    14521 gtgctgaacg gcgcgccgag cgagcccagg cgcacgcccg cggcgggccg cgtgaggcga
    14581 agggcgctga caggacagga ggccaccgcc gagcgcgccg ccgcgagatc ggccagactc
    14641 tgcggttggc gcagcacgcc cgtgaaggac ccctcgtcgt aggtgccttc cagcacggcg
    14701 gggccgcggc gcgcgacgtc gcccacgtcg cccacgtcgc ccacgtcgcc gtcgagcgcc
    14761 gcccagtgcg cgggcgttac ctcgccgagg agctcaggag cgaagttcct gcagacccct
    14821 gcgccacagc aggcgcgcgt gacgtgcagc tgtccccagt cgctcttgcc atccttatcg
    14881 cagagctcgt tgtgtgtggt acccatgcag ggtacctatc acgccacctg cgcgaaggcc
    14941 tgtgtgtcgg agcgccacat gcggtgtctt ccgcggtcag gtcttgaccg cgcccgcggt
    15001 gagcccctgg acgaggtagc gctggagtac gagaaacccg gtgaccacgg gcacactgac
    15061 gacgacggag gcggccatca cctggttcca gtagatgttc gactgggtcg cgtacccctg
    15121 cagcccgacg gcgagggtgc gcccgtcgtc gtccgtgagc acggaggcga acaggacctc
    15181 tccccacgcg gtcatgaagg cgtagatcgc gaccgcgacg acgcccggct tggccaccgg
    15241 gagcacgacg cggaggagcg ccgtgagcgg cctggcgccg tccaccagcg cggcctcgtc
    15301 gagctcgcgc gggatggtgt cgaagtaccc cgcgatgagc cagatggaga acggcagcga
    15361 gaaggtcagg tacgtgatga tgaggccgag gcgcgtcccg tggagctcga gccccagggt
    15421 ccgctcgatc tggacgaaga tcagaaagag cgggagcagg aagaggatcc cggggaacat
    15481 ctgcgtggac agcacggtgg tgaggaacgc gcgccggccc cagaagcggt acctgctcac
    15541 cgcgtacccc gcgaggatcg ccagcgccac cgagaacacc gtcgaggcgg ccgcgacgac
    15601 ggcgctgttc acgaagtagc gcgcgagcgg cacggtccgc cacatgtcga agaacggctg
    15661 gagcgtgacc tcggtcggga gccaggtgaa gggcccctgg acgtcgcgca gcggcttgag
    15721 cgccgaggtc accatgacat agagcggcac cacggtgaag accgcgagcc ccgcgagcac
    15781 ggcgcgccgc agccagacga cccaggcggg ctcacgcatg gcgcgcgctc ctgccggaga
    15841 tcaggagata ccccgtggtc acgaggagca gaaagccgac gaggagcacc gacatggccg
    15901 atcccagccc gaagttccac gtgatgaacg acgcctgata gatgtggatc gcgatgacgc
    15961 ccgcctccgg cggcgccgat cggccgaaga gcgtgaaggg cgtcgtgaag tcgttgaagc
    16021 tccacaggaa gaggacgagc agcagcactt ggttgaccgg ccggagcatc ggcagcgtga
    16081 tcgaccggaa gcgcgtccac gggccggcgc cgtcgacgct cgccgcctcg tagaggtccg
    16141 aggggatcgc ctggaggccc gccgtcaccg tgaggaaggc gaacggccag gtccgccaga
    16201 tcgccaccac caccaggctc gcgaagctgt tcgggccgag cagccagaac gggcgctcgt
    16261 cgacgaggcc cagctgatcg acgagcaccg tgttcacgat gcccgtgtcg cgctgcagca
    16321 tgaagctcca ggtgatgacg ccggtgaaga tcggcatcgc gaacgggacg aggaacaacg
    16381 tccggagcgc cgtgcggccg gggaacggct tctgcagcgc gaccgcggcc gcggtcccga
    16441 acagccacga gccggcgacc acgagcaggc tgaaggcgac cgtgatgaag aaagagcgga
    16501 ggaggttctc gccgaccggc gagctcacgt cgatcgcgat tcggtagttg gcgagcccca
    16561 cgacgggcgc cttggcccag ttgcggatga agcgctgcgt gagctggagg aagctcatcc
    16621 ccgccccgac gaacatcggg acgaggtgga cggcgagctc ggcgaccagc gcggggagca
    16681 ggaacacgta cggcaggacc cggctctgcc agcgccgccg cggggccttt cgcggcctcg
    16741 cggcggcggg cgccccggcg aggggaggtg cgcctcgccc ggcgccctcc gtgctggtgc
    16801 cgccgcccat tacttcccgc tcgccatctg ctggttggcc gcggtcagct tgccgcggat
    16861 cgaggcgtcg gtgaccgcct tgccggaggc ggcctcggcc aggaggtccc tcatggccgt
    16921 gcccacgagc gtctcgaact gcgccgtctc ctcgatcatc ggcatcgact ccgccgtctc
    16981 ggccagcacc ttctggaaca cctgggtgtt cgcgctcttg aagcgctcgt cggcgtaggc
    17041 ctccgacacg accgggaggc tgccgaaggc gccgttcagg atcttctgct cctcggggct
    17101 cgtcatgaac gcgacgaact tgagcgccgc gtcccggttc ttgctctcct cgaacacggc
    17161 gatgttgatg ccggccacgt ggctgttcac cgccttgccg cccgcgggca gcgggtcggg
    17221 catcgggacg ggcgccacgc cgtacgcgtc gcgggccatg ccgttctgct cgatcgccgc
    17281 ctgggcgtag ctctggatca tgagcatcgc cgccttgccc gaggtgaact ccttcagcat
    17341 ctgcgtgtcg ttgacgtact ccgcgttgct cgggttcacg accttgtgga cgctgaggag
    17401 atcgatgtac tgcttgacgc cggcgaccat ctccggggcg tcgaaccggg gctgtttgcc
    17461 ctcgaagatc gcggcgccgt gctgccggcc gaacatgaac gcgaagtggg cgttctcgct
    17521 gtagctcgcg cccatgatgg cgacgccgta acggccgccc ttcgcgtcgg tgagcttctt
    17581 ggcgacggtg atgaactcgc cccagttcgc cggcggcttc tcgatcccgg cgtcggcgaa
    17641 catcttcttg ttgtagaaga ggccgtaagc gagcccgtag agcggcaccg cggcgggcgg
    17701 ctggcccgcc gcgccggtgg cggacagggt cgtcgcgacg aaccggtcct tgccgccgat
    17761 cttggcgagc gcggcgtcgt cgaacggcag gaacgccccg gtggcctgca gcgacgcaga
    17821 ccacgagttg ccgatgttga ggacgtcagg gcccttgccg ctcgaggtgg cggccaggat
    17881 ccggttgagc aggtccgacc aggagatgac ctcgagcttg accttgatcc cggtctgctt
    17941 ctcgaacttg tcgagctcgg gctggaggat cttccggtcg tcctccacgc tgggcgcctg
    18001 gttgctcgcc cagtacgtca gcgtcaccgc ctcggccgcg ggcgctcccc gcgctccttg
    18061 cgctccctgc gcggaagacc cgggcgacgc ggacggcgcg tcgcccccgc tcttgccgca
    18121 ggcggcggtc ccgagggcga gcagggcaca tgcggctacg gcgtcgagga tgcgtgattt
    18181 cacggtggct ctttctccgt cggcaggtcc acaacatcgc gcaaatcgcg caacgccgcg
    18241 caggctatcc tctgcgcggg caggcttgca aggacggcaa ggcgagctgt gcgctcactc
    18301 cgcctccagg cgcacaacag gtctgcaacc gccgtcgcag cgcggcgcgg agcgcctcct
    18361 gcgacgtggc cagacatgaa cggaaagccc ggcgagtaga gcacttaatc ggtttagtgt
    18421 ccagggtcct cgcgggccct ggcctggtcg gccgcagggc ggcggcgtgg cgggctgccc
    18481 ccgggagcgc gggtatctgt caagccgcgc gagccgcgcc caggaacgcc cggatcgcgg
    18541 cgagcgcctc ggcgcgcgcg tcgtcgagca cggcgtgccc cgcgctcggg aagcgcctaa
    18601 tctggacgag ctccggcggc agcgccgccg cgagctcgcg cgcgtcctcg gtcgtcgcga
    18661 acgggtcgag atcgccggag aggacgaggg tggggcagcg gacgcgcgcg agatccgcgc
    18721 ggaggtcgaa cgtctgcatc tcgccggcca cgaagtagcc gcccacgtcg aggtggagga
    18781 ccgcgcgctc gaccgcgcct tgctcgggcg gggactgccg gtaaagcggg aagcagacgt
    18841 cgatgtactc cgggaacgtg gccctcggat ccgcgaagaa gcggcgggcg acgccggccg
    18901 cgcgcgcgcc gccgagccgc tcgaacatca ccagcatgcg gtcgaggcgg agccgcgccg
    18961 tcgtgctcac caggatgagc ttcgccgggt gatccgggtg ccgcgccgcg taggcctgcg
    19021 ccaccatgcc gccgaacgac gagcccagca ccacgggccg ctcgatgtcg agcgcatcgc
    19081 agaaggcccg cacgtcgtcc gcccacgtgt ccaggttcca gcgctcgggc ccgctgcggt
    19141 cgctgcgccc cgagccgcgg tgatcgaggt agatgacctg cgcgacgtcg gcgagcgccg
    19201 agccgaaggg cctgaactcg gtgtgatcga agcccggccc gccgtgcagc aggagcaccg
    19261 tggggcgctc gcgcatcgcg ggcccgtcgg gcacgagctt cgacccttcc acatcaaaga
    19321 acagccgggt gtcgcctgcc tggactctca tcgtgatgca gtgaaatcac aacgcgcagc
    19381 gccgcgccag accctctctc aggtcgatcg cccgacgtgt ggcggatcgc ctcaccctgt
    19441 gctgctgcgc gcgtgcgacg cggcggctgg gcccgccggg ccgcgcgtca cttcagcagg
    19501 gccgggagca cgcgctcgcc gaaggtgtcg atgaaggcct gctggttcga ggtcacgtta
    19561 tgaacgtaga tcgcgtcgaa gccgagctcg gcgtgctcgc gcagccaggc cgcgtgccgc
    19621 gcggggtcgg ccgagacgtg cacctgcgcg gcgacgtcct cggggcgcac gaaggaggcg
    19681 gccgcgtcga agtgctccgg caccgtcagg ctcgcgagca gccgcggcgg gagcacgttc
    19741 gtccgccact gctcgtgggc ctcgcgcagc gcgacacgct cgtcggggtc gtacgcgatc
    19801 ttcacctgga gcaccatcgg cttgccctcg ccgccgccct cccggaagcg gcgcaccacc
    19861 tcgcggagct ggtctctccc ctgcgacacc gtgatcagcc cgtcggccca ccggcccacc
    19921 cgcgccgcgg tggccgccga gatggccgcg ccgaggagcc gcggcggcgc cgcgggccgc
    19981 gtatagagct tcgcgccgtc caccacgacg cggccccggt gggtcacttc ctcgccgcgc
    20041 cacagcgccc ggatgacctc ggcgcactcc tcgaggcgcg cggtccgctc ggcgtgatcg
    20101 ggccacttct ccccggtgat atgctcgttc agcgcctcgc cgctgccgat cgagagccag
    20161 aaccggcccg ggtacatctc ggccagcgtg gcggccgcct gcgcgatcac cgcgggatgg
    20221 tagcggtagc cgggggcgca gaccgtcccg aacgacaggg acgtggcctc cagcgccgcg
    20281 ccgagccacg cccaggcaaa gccgctctgg ccttgcttct cgccccaggg gaggaagtga
    20341 tccgagcaca tcgcccccgc gaacccggcc tgctcggcgt ggcgcacgtg ccggagcaag
    20401 gccgaagggg cgagctgttc gtgggacgcg tgataaccga tcgcgagctt gcgcatgagt
    20461 tcgccaggat ccttgtcgcg ccgacgaggg ccggcgcgct ccggcgcctg cgtgagcaat
    20521 cggcgcgcca ggggcgcctc gcgcggcctg gcacggcccg gccgcccggc cggccgtctt
    20581 gggctcactc gagcaggatg tccgccgcgg cgagcccggc ggcctgcgtc agccgccgca
    20641 tgtaatccca gttgagccgg tcgaccgtgt cgcagcgggc gtggtagcag gggttgccgt
    20701 ctcccccgaa gaaggcctgt gataccgcga ctgccggctt cccgtaacgc cagaacgcgg
    20761 cgtggtcgct gcggtccgtg caggcgtcca cccgggtcag gcccaggtcg ccgcgcaccg
    20821 ccgcggcctc gacgcggtcg gccagctcgg ccgaggtgtt ctcgttgcag tggatgacat
    20881 ggtatttccc atcgtcgttg gcgtcgtagg cggtcatctc gagatcgatg acgccgacca
    20941 cctgctccat ttgcccggcg cgagcgagca tgcgcgcata ggcgttcgag ccgagcaacc
    21001 cgctctcctc ctggtcgaag gcgacgacac ggagcgagat ccggaggggc gcctccgcga
    21061 gcgcgcgtgc gatcgcgagc gatgacacga ccccggagcc gtcgtcgtcg gcgccggcgt
    21121 tgttggttga atcgtaatgc gccgagacga tgaggacccg ggacgggtcg gcgccggcct
    21181 tctccgcgac gacgttgacg ccgcgctcga agccgctgtc atacgcgtgc tcctcgacgg
    21241 tgaacccgag cgcctcgtac tgctcgcgca gccagccgcg ggcgagggcg cgcccgccgg
    21301 cggagccgcg ctcgcggatg accacggcgc ggccgccgac ggtcgcggtc gcggcgccgg
    21361 agagctccct gaggcgcgcc tcgaggaact ccggctcgat ggtcatcacg gtgtccacgc
    21421 ccacgagcga gccatggatt tcgtccgccg ccggctcgct caggtcttct accgcgcacg
    21481 aggccgaggc cagcgcaaac gcagcacaga tcccggcgaa gacgcgcgaa ggatcacggg
    21541 tcgatgtcat tgagtcctcc ctttcggggc accctatgga tctcgcctcg aggatccaag
    21601 aactatcttc acgacagaga cgttaccggc ggctcacgtg gtgttgagcg gatggcagga
    21661 cacagttgtg ctgcggtgga cctatcgagt catggtccag cctgtcgggc cgatacggcc
    21721 gctacccgcc gccggggcgg tgcagcgtct cgggaaagct gggcgcgggc gtatcgacag
    21781 gggccgacgg cgccgcgggg gccgacggcg ccgcgggcgc ggccggcgct ccgggcgcgg
    21841 acggcgctgc ggccgcctct ctcggggcgc cgtcgcgccg cgcgagctgc ccgcggcggc
    21901 aggtgtcgat cgtgtcgatc gccgacgcga ggatgcgcat cgactcctgc ggcgcgtgga
    21961 agccggacga gttctcggcc tcggcgaagt cgaggaagaa ctggcacttg cgctgggccg
    22021 cgcgcgcctc ggcgagggcg tcgtcggctt cgcccgctgg atgtcgccga tcagcgcggt
    22081 caccgcgtcg agcgccgggt cggccatccg tgcgccgacg cgcaggtcct gcgccccgcg
    22141 gcggccgttc ccgtcggggc gcggctgcgc tatcggtggc cgaggagaaa gccctcgtga
    22201 acgccacgcc cgacacacga a
//
