LOCUS       NZ_POVS01000022        22169 bp    DNA     linear   CON 15-SEP-2024
DEFINITION  Paenibacillus sp. F4 F4_contig_21, whole genome shotgun sequence.
ACCESSION   NZ_POVS01000022
VERSION     NZ_POVS01000022.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus sp. F4
  ORGANISM  Paenibacillus sp. F4
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 22169)
  AUTHORS   Jeong,H., Park,S.-Y., Choi,S.-K., Ryu,C.-M. and Park,S.-H.
  TITLE     Genome sequencing and comparative analysis of polymyxin-producing
            Paenibacillus strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 22169)
  AUTHORS   Jeong,H., Park,S.-Y., Choi,S.-K., Ryu,C.-M. and Park,S.-H.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JAN-2018) Infectious Disease Research Center, Korea
            Research Institute of Bioscience and Biotechnology (KRIBB), 125
            Gwahak-ro, Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 11-JAN-2018
            Assembly Method                   :: CLC Genomics Workbench v. 11.0
            Assembly Name                     :: F4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 524.4x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002894905.1-RS_2024_09_15
            Annotation Date                   :: 09/15/2024 04:37:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,419
            CDSs (total)                      :: 5,299
            Genes (coding)                    :: 5,203
            CDSs (with protein)               :: 5,203
            Genes (RNA)                       :: 120
            rRNAs                             :: 10, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 1 (5S, 16S)
            partial rRNAs                     :: 2, 1 (16S, 23S)
            tRNAs                             :: 102
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 42 of 96
            Pseudo Genes (incomplete)         :: 67 of 96
            Pseudo Genes (internal stop)      :: 14 of 96
            Pseudo Genes (multiple problems)  :: 22 of 96
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:44:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 22169
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            POVS01000022.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..22169
                     /collected_by="Seung-Hwan Park (KRIBB)"
                     /db_xref="taxon:357385"
                     /mol_type="genomic DNA"
                     /organism="Paenibacillus sp. F4"
                     /strain="F4"
                     /submitter_seqid="F4_contig_21"
     region          1..22169
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /product="transAT-PKS"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX) and not alpha_am_amid)"
                     /rules="(cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or
                     ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or
                     cds(tra_KS and PP-binding)))"
                     /tool="antismash"
     cand_cluster    1..22169
                     /SMILES="C[*]C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /detection_rules="(cds(PKS_AT and not (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and
                     (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
                     or cds(tra_KS and PP-binding)))"
                     /kind="chemical_hybrid"
                     /product="NRPS-like"
                     /product="transAT-PKS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22169
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[3799:7906](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3800..7906
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     protocluster    1..22169
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[2601:7906](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PKS_AT and not (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and
                     (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
                     or cds(tra_KS and PP-binding)))"
                     /neighbourhood="20000"
                     /product="transAT-PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      2602..7906
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PKS_AT and not (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and
                     (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
                     or cds(tra_KS and PP-binding)))"
                     /neighbourhood="20000"
                     /product="transAT-PKS"
                     /protocluster_number="2"
     assembly_gap    176..409
                     /estimated_length=234
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <410..2387
                     /locus_tag="C1T21_RS25085"
                     /old_locus_tag="C1T21_25090"
     CDS             <412..2387
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: PCP (43-109). E-value: 1.8e-21. Score:
                     68.1. Matches aSDomain: nrpspksdomains_C1T21_RS25085_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (265-416). E-value:
                     2.6e-22. Score: 71.2. Matches aSDomain:
                     nrpspksdomains_C1T21_RS25085_Condensation_LCL.1"
                     /codon_start=2
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014281409.1"
                     /locus_tag="C1T21_RS25085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25090"
                     /product="condensation domain-containing protein"
                     /protein_id="WP_258012620.1"
                     /sec_met_domain="PP-binding (E-value: 6.8e-15, bitscore:
                     45.5, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.9e-20, bitscore:
                     63.1, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PSYFVQLESMPLTPNGKIDRKALPLPELANSPDAGYVAPRNEMEQ
                     QLANLWQTVLGREKVSIDENFFELGGHSLKAIQLVTKAQESGIPLGIHQVLQHQTIRSL
                     SDLLSLNKVATKQDTSLLTDLTEAEQWISETFGVQAMLQFVANDEHDYLFLQIYPFRPD
                     QVSEMTVGISSHIHSELHPHYIVPMGEEDASQWVSTEYTELEQTDEEQANSRQRPLESE
                     EWIIKIAKMNARWNKYLLSSKVIYRFPLAPAQHYHLVHPASSGTVIRLDQYVDVERLTT
                     AVRQLIQRHELLRSVLVCSDGIWEWEVRPTPEHISLPCVDLSVYPVQEQQQLLPSIMSN
                     LYFEPYEQTQSLQYRITLVRLNLREHLLLLPCSHIIFDATSSVVLHNQLLEEYDHTQQS
                     QTVKTFHYHDYVDLIRQGPQGISDQDIVEQFKLQAFDNNNSRIHARMRECNYAQSTSLI
                     WELKLHDIQKQDVAASLSDISLQIGFQFFSRYFEQSEVPLWLTQYGRQYGARNYFGSLG
                     EYIDHIPVLLQKEEEISYENDIQKPLDVAVNHHLNFFNLIFNEEMKSVYPQSSSILKKN
                     FEQLPIVFNYLGEMKEDSKLLGALNRPKKEANGGGAIFFESAYTASVLKISLSLPYEED
                     CEEIYQIFQAATEKVLLNLTIPQ"
     aSDomain        543..740
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C1T21_RS25085_PCP.1"
                     /evalue="1.80E-21"
                     /label="C1T21_RS25085_PCP.1"
                     /locus_tag="C1T21_RS25085"
                     /protein_end="109"
                     /protein_start="43"
                     /score="68.1"
                     /tool="antismash"
                     /translation="EQQLANLWQTVLGREKVSIDENFFELGGHSLKAIQLVTKAQESGI
                     PLGIHQVLQHQTIRSLSDLLS"
     CDS_motif       606..635
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25085_0001"
                     /evalue="4.10E-03"
                     /label="PCP_mC"
                     /locus_tag="C1T21_RS25085"
                     /protein_end="74"
                     /protein_start="64"
                     /score="10.5"
                     /tool="antismash"
                     /translation="NFFELGGHSL"
     CDS_motif       1209..1304
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25085_0002"
                     /evalue="4.30E-09"
                     /label="C2_DCL_024-062"
                     /locus_tag="C1T21_RS25085"
                     /protein_end="297"
                     /protein_start="265"
                     /score="28.7"
                     /tool="antismash"
                     /translation="TVIRLDQYVDVERLTTAVRQLIQRHELLRSVL"
     aSDomain        1209..1661
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C1T21_RS25085_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.60E-22"
                     /label="C1T21_RS25085_Condensation_LCL.1"
                     /locus_tag="C1T21_RS25085"
                     /protein_end="416"
                     /protein_start="265"
                     /score="71.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: SHIIFDA"
                     /tool="antismash"
                     /translation="TVIRLDQYVDVERLTTAVRQLIQRHELLRSVLVCSDGIWEWEVRP
                     TPEHISLPCVDLSVYPVQEQQQLLPSIMSNLYFEPYEQTQSLQYRITLVRLNLREHLLL
                     LPCSHIIFDATSSVVLHNQLLEEYDHTQQSQTVKTFHYHDYVDLIRQ"
     gene            2602..3825
                     /gene="fabD"
                     /locus_tag="C1T21_RS25090"
                     /old_locus_tag="C1T21_25095"
     CDS             2602..3825
                     /EC_number="2.3.1.39"
                     /GO_function="GO:0004314 - [acyl-carrier-protein]
                     S-malonyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_AT (6-290). E-value: 3.9e-62. Score:
                     202.2. Matches aSDomain:
                     nrpspksdomains_C1T21_RS25090_PKS_AT.1"
                     /codon_start=1
                     /gene="fabD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     transAT-PKS: PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007430457.1"
                     /locus_tag="C1T21_RS25090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25095"
                     /product="ACP S-malonyltransferase"
                     /protein_id="WP_103050198.1"
                     /sec_met_domain="PKS_AT (E-value: 1e-62, bitscore: 202.2,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRTALVFPGQGSQYVGMGAAWHSGFTEADRLFEEAADILGYDLK
                     ALCMAGPITQLSRTFYTQPALLTISVIAFRRYMHEIGIIPEFSAGHSLGEYSALVSSGV
                     LSFGDALRLVQERGRFMEEAAVAGLGSMIAVRGAEPGAVEEFCRLHSTVDQPAAIACYN
                     SPNQYVVSGHSTSVAVVAGELEQRGAQITRLQVSGPFHSPLMQPAADRLTAELQKYTLN
                     EAKWPVISNVTAQPYPDVDSIRQGLILQMTHPVRWIQTMQYMANHGVKQGIELGPRTVL
                     KNLTKEINTSIELLSLDRDLDRVELERRFSIRDWVARSLSLAVSTPNANWNEDEYRKGV
                     ILPVRRLEELLRNSESDSSPPPASEQRQEILGCIRLVLQTKQVSEGEQKVMLEQLRRDQ
                     DGAVSNFN"
     CDS_motif       2617..2661
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25090_0001"
                     /evalue="2.00E-06"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="C1T21_RS25090"
                     /protein_end="20"
                     /protein_start="5"
                     /score="20.0"
                     /tool="antismash"
                     /translation="LVFPGQGSQYVGMGA"
     aSDomain        2620..3471
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C1T21_RS25090_PKS_AT.1"
                     /evalue="3.90E-62"
                     /label="C1T21_RS25090_PKS_AT.1"
                     /locus_tag="C1T21_RS25090"
                     /protein_end="290"
                     /protein_start="6"
                     /score="202.2"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="VFPGQGSQYVGMGAAWHSGFTEADRLFEEAADILGYDLKALCMAG
                     PITQLSRTFYTQPALLTISVIAFRRYMHEIGIIPEFSAGHSLGEYSALVSSGVLSFGDA
                     LRLVQERGRFMEEAAVAGLGSMIAVRGAEPGAVEEFCRLHSTVDQPAAIACYNSPNQYV
                     VSGHSTSVAVVAGELEQRGAQITRLQVSGPFHSPLMQPAADRLTAELQKYTLNEAKWPV
                     ISNVTAQPYPDVDSIRQGLILQMTHPVRWIQTMQYMANHGVKQGIELGPRTVLKNLTKE
                     INT"
     CDS_motif       2845..2967
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25090_0002"
                     /evalue="7.40E-16"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="C1T21_RS25090"
                     /protein_end="122"
                     /protein_start="81"
                     /score="50.2"
                     /tool="antismash"
                     /translation="GIIPEFSAGHSLGEYSALVSSGVLSFGDALRLVQERGRFME"
     CDS_motif       3079..3117
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25090_0003"
                     /evalue="4.20E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="C1T21_RS25090"
                     /protein_end="172"
                     /protein_start="159"
                     /score="10.5"
                     /tool="antismash"
                     /translation="ACYNSPNQYVVSG"
     gene            3800..7906
                     /locus_tag="C1T21_RS25095"
                     /old_locus_tag="C1T21_25100"
     CDS             3800..7906
                     /NRPS_PKS="Domain: CAL_domain (34-480). E-value: 1.7e-144.
                     Score: 474.2. Matches aSDomain:
                     nrpspksdomains_C1T21_RS25095_CAL_domain.1"
                     /NRPS_PKS="Domain: PCP (585-654). E-value: 6e-19. Score:
                     60.0. Matches aSDomain: nrpspksdomains_C1T21_RS25095_PCP.1"
                     /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (676-1098). E-value:
                     3.8e-156. Score: 512.2. Matches aSDomain:
                     nrpspksdomains_C1T21_RS25095_PKS_KS.1"
                     /NRPS_PKS="Domain: Trans-AT_docking (1117-1259). E-value:
                     4.6e-29. Score: 93.7. Matches aSDomain:
                     nrpspksdomains_C1T21_RS25095_Trans-AT_docking.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     transAT-PKS: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     transAT-PKS: tra_KS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     transAT-PKS: ATd"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371225.1"
                     /locus_tag="C1T21_RS25095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25100"
                     /product="beta-ketoacyl synthase N-terminal-like
                     domain-containing protein"
                     /protein_id="WP_258012622.1"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-88, bitscore:
                     286.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.7e-18, bitscore:
                     56.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.1e-74, bitscore:
                     240.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 1.3e-157, bitscore:
                     515.0, seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="ATd (E-value: 1.2e-29, bitscore: 93.7,
                     seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQFQTLIEIIQDRANRDEHGITFISGDKQEEYVSYSKLLEQALQ
                     VLHELQEKGIQPGDELIMQIDDNHTFVNVFWGCLLGGIVPVPVSIGNNDEHKMKLFKIW
                     NTLSCPYMIADDKVLEQLEKYSHQHQLLDSFEPVKKATFSSHTFDYSNQSKGVVHISKP
                     EDLAFIQFSSGSTGDPKGVMLTHENLIYNIRDIANQTGMSSKDAYLGWMPLTHDLGLIA
                     FHLTCVIANAKQLIMPTALFIRRPSLWLKKVSEHKVTQICSPNFGYKFFLDQYKPETAS
                     NWDLSSVRMILNGAEPVSVELCHVFMDAMSVHGLNKNVMFPVYGLAEASVGVSTPPLDK
                     DTFLPIHLNRQQLHVGEPIEEVDKSDKRCLTFVDLGYPMASTSVRICDDQNQVLEDGVI
                     GHTQICGKNVTSGYYNNPEATAKVKTEDGWLITGDLGFMRNGRLTITGRAKDIIFVNGQ
                     NVYPHDIERIAEELDGVDLGKVAVCGVHDAQTRQDRIVAFVMHTKKIEHFVPLVQKLKS
                     HLNYRGGWYIQDVVPIRRIPKTTSGKVQRFKLAQSYEQGEFNEILTTLAEATQTVPAAE
                     HKILPQGEIEQKLIGICQDILNVKSIGTDDSYFDIGVNSLQLVQIVDLLEDQLGIHIKV
                     TDFFSYPTIAKLAAYISSQDLSSEAAATAQPEAKEKVNDRDIAIIGMSGKFPQAETLEQ
                     FWANMASGADNIGPYSDERRKDAEDFISRLNTEGRNMQIAEGGYLDEVDKFDYSFFKLT
                     PREASLMDPNQRLFLQTAWSTIEDAGYGGKQLAGQKVGVYVGFSKTSFEYERLLSEVEP
                     GALPNFAIGNLSSIISSRIAYLLDLKGPALTIDTACSSSLVAVHLACKSILSGDCDMAL
                     AGGVKTILLPLKAGIGMESSDDRARAFDDQSDGTGWGEGVGAVFLKPLRKAEQDGDNIL
                     AVIKGSAINQDGSTIGISAPNALAQAEVILQAWRDARINPETISYIEAHGTGTKLGDPV
                     EIDGITKAFRKHTQRKQFVAISTVKTNIGHLYEAAGIAGLIKSVLSLKYQQIAPLVHFR
                     APNQKIHFEESPVYANTKLREWKTDGFPRRSGLSSFGFSGTNCHVVLEEYIAKTESDQT
                     STDSNNRSSPLLLTLSARSESALRELVGRYAERFRRGEELVIQDVCYTANTGRGHLNHR
                     IAMTAAGGDSLKAKVFQLHEQGRVVEGVYTGEADSTGSAEIVTGSLDTLQSLEQLAAKY
                     VQGAQINWNALYAGKHYKKVSLPTYPFERKRCWVNVPEQVRTEQKATVQSVQNRPETSL
                     NQVDHAAFPLTQPSHESTVPAGASVYAMDTAGQIRTQSVPNATASAVVERILEQQLRLM
                     SQQLDVLRGQSSPSVKSVSKNVGNH"
     aSDomain        3902..5239
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C1T21_RS25095_CAL_domain.1"
                     /evalue="1.70E-144"
                     /label="C1T21_RS25095_CAL_domain.1"
                     /locus_tag="C1T21_RS25095"
                     /protein_end="480"
                     /protein_start="34"
                     /score="474.2"
                     /specificity="Minowa: fatty_acid"
                     /tool="antismash"
                     /translation="SYSKLLEQALQVLHELQEKGIQPGDELIMQIDDNHTFVNVFWGCL
                     LGGIVPVPVSIGNNDEHKMKLFKIWNTLSCPYMIADDKVLEQLEKYSHQHQLLDSFEPV
                     KKATFSSHTFDYSNQSKGVVHISKPEDLAFIQFSSGSTGDPKGVMLTHENLIYNIRDIA
                     NQTGMSSKDAYLGWMPLTHDLGLIAFHLTCVIANAKQLIMPTALFIRRPSLWLKKVSEH
                     KVTQICSPNFGYKFFLDQYKPETASNWDLSSVRMILNGAEPVSVELCHVFMDAMSVHGL
                     NKNVMFPVYGLAEASVGVSTPPLDKDTFLPIHLNRQQLHVGEPIEEVDKSDKRCLTFVD
                     LGYPMASTSVRICDDQNQVLEDGVIGHTQICGKNVTSGYYNNPEATAKVKTEDGWLITG
                     DLGFMRNGRLTITGRAKDIIFVNGQNVYPHDIERIAEELDGVDLGKV"
     aSModule        3902..5761
                     /complete
                     /domains="nrpspksdomains_C1T21_RS25095_CAL_domain.1"
                     /domains="nrpspksdomains_C1T21_RS25095_PCP.1"
                     /locus_tags="C1T21_RS25095"
                     /monomer_pairings="fatty_acid -> fatty_acid"
                     /starter_module
                     /tool="antismash"
                     /type="cal"
     CDS_motif       4298..4357
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25095_0001"
                     /evalue="1.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="C1T21_RS25095"
                     /protein_end="186"
                     /protein_start="166"
                     /score="24.0"
                     /tool="antismash"
                     /translation="AFIQFSSGSTGDPKGVMLTH"
     CDS_motif       4985..5065
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25095_0002"
                     /evalue="1.10E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="C1T21_RS25095"
                     /protein_end="422"
                     /protein_start="395"
                     /score="24.2"
                     /tool="antismash"
                     /translation="DGVIGHTQICGKNVTSGYYNNPEATAK"
     CDS_motif       5135..5197
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25095_0003"
                     /evalue="8.80E-05"
                     /label="NRPS-A_a8"
                     /locus_tag="C1T21_RS25095"
                     /protein_end="466"
                     /protein_start="445"
                     /score="15.2"
                     /tool="antismash"
                     /translation="TGRAKDIIFVNGQNVYPHDIE"
     aSDomain        5555..5761
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C1T21_RS25095_PCP.1"
                     /evalue="6.00E-19"
                     /label="C1T21_RS25095_PCP.1"
                     /locus_tag="C1T21_RS25095"
                     /protein_end="654"
                     /protein_start="585"
                     /score="60.0"
                     /tool="antismash"
                     /translation="EQKLIGICQDILNVKSIGTDDSYFDIGVNSLQLVQIVDLLEDQLG
                     IHIKVTDFFSYPTIAKLAAYISSQ"
     aSDomain        5828..7093
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C1T21_RS25095_PKS_KS.1"
                     /domain_subtypes="Trans-AT-KS"
                     /evalue="3.80E-156"
                     /label="C1T21_RS25095_PKS_KS.1"
                     /locus_tag="C1T21_RS25095"
                     /protein_end="1098"
                     /protein_start="676"
                     /score="512.2"
                     /specificity="transATor: (unknown)"
                     /tool="antismash"
                     /translation="IAIIGMSGKFPQAETLEQFWANMASGADNIGPYSDERRKDAEDFI
                     SRLNTEGRNMQIAEGGYLDEVDKFDYSFFKLTPREASLMDPNQRLFLQTAWSTIEDAGY
                     GGKQLAGQKVGVYVGFSKTSFEYERLLSEVEPGALPNFAIGNLSSIISSRIAYLLDLKG
                     PALTIDTACSSSLVAVHLACKSILSGDCDMALAGGVKTILLPLKAGIGMESSDDRARAF
                     DDQSDGTGWGEGVGAVFLKPLRKAEQDGDNILAVIKGSAINQDGSTIGISAPNALAQAE
                     VILQAWRDARINPETISYIEAHGTGTKLGDPVEIDGITKAFRKHTQRKQFVAISTVKTN
                     IGHLYEAAGIAGLIKSVLSLKYQQIAPLVHFRAPNQKIHFEESPVYANTKLREWKTDGF
                     PRRSGLSSFGFSGTNCHVVLEEY"
     aSModule        5828..7576
                     /domains="nrpspksdomains_C1T21_RS25095_PKS_KS.1"
                     /domains="nrpspksdomains_C1T21_RS25095_Trans-AT_docking.1"
                     /incomplete
                     /locus_tags="C1T21_RS25095"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       6314..6361
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25095_0004"
                     /evalue="7.90E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="C1T21_RS25095"
                     /protein_end="854"
                     /protein_start="838"
                     /score="20.9"
                     /tool="antismash"
                     /translation="GPALTIDTACSSSLVA"
     CDS_motif       6722..6769
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25095_0005"
                     /evalue="8.90E-05"
                     /label="PKSI-KS_m5"
                     /locus_tag="C1T21_RS25095"
                     /protein_end="990"
                     /protein_start="974"
                     /score="14.3"
                     /tool="antismash"
                     /translation="YIEAHGTGTKLGDPVE"
     aSDomain        7151..7576
                     /aSDomain="Trans-AT_docking"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C1T21_RS25095_Trans-AT_docking.1
                     "
                     /evalue="4.60E-29"
                     /label="C1T21_RS25095_Trans-AT_docking.1"
                     /locus_tag="C1T21_RS25095"
                     /protein_end="1259"
                     /protein_start="1117"
                     /score="93.7"
                     /tool="antismash"
                     /translation="LLLTLSARSESALRELVGRYAERFRRGEELVIQDVCYTANTGRGH
                     LNHRIAMTAAGGDSLKAKVFQLHEQGRVVEGVYTGEADSTGSAEIVTGSLDTLQSLEQL
                     AAKYVQGAQINWNALYAGKHYKKVSLPTYPFERKRCWV"
     misc_feature    8187..8200
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 21.35"
                     /tool="antismash"
     gene            8270..10297
                     /locus_tag="C1T21_RS25100"
                     /old_locus_tag="C1T21_25105"
     CDS             8270..10297
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017428562.1"
                     /locus_tag="C1T21_RS25100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25105"
                     /product="S9 family peptidase"
                     /protein_id="WP_103050189.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 6.6e-57, bitscore:
                     182.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNSQFSMAKRRITAEDLYRLHWVSDPAVHPISGEIAYVEQYINE
                     EHTDYNSGIWLLPFQGDAPIPFTYGPKDETPVWSPDGSQLAFLRTTDGKRQVWIIPARG
                     GEARQLTHVENNVRSLAWSPDGACISFVAKTAENQSSPTSDTGNQEAQLKGRVVNRTKA
                     KSDGYGLWDDTRDHLYVTDVTSGHTVQLTSGAYDVAEPVWSPDGQRILFVARIAEHSKE
                     DMDLRKQNDLFTIAPAISNGDAAAPLKLTHSKLHIESAAYSPDGSTIAFYGHDRHAKDA
                     TQTRLYTIPSSGGTAVCVSETLDAHFGNAGMSDMRSHLHIGPPRFSADSQSLYTLVTLE
                     GNVHVYQFALDGTFKILTQGEREIYQFDLTSDEQHIIAASTDVALPGDLFRIAIHSGTD
                     ERLTRVNDSLLDEIEISMPESFWTEVEDGRRVQGWVMKPVGFKEGVSYPAILEIHGGPH
                     AMYSNSFFHEFQLLAAQGYAVIYTNPGGSRGYGQSFTNVVLGDYGGRDYTDLLSAVDEA
                     IRQFPFIHPERLGVTGGSYGGFMTNWIVGHTDRFRAAVTQRSISNWLSMYGVSDIGYSF
                     TEDEVGGNPWEDCELLWKQSPLAYVQQINTPLLILHGEQDLRCPIEQGEQLFTALRRLG
                     KPTQFVRFPASSHELSRKGHPQLRVERLQRITNWFAEHEI"
     gene            10412..11515
                     /locus_tag="C1T21_RS25105"
                     /old_locus_tag="C1T21_25110"
     CDS             10412..11515
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019687211.1"
                     /locus_tag="C1T21_RS25105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25110"
                     /product="hypothetical protein"
                     /protein_id="WP_103050190.1"
                     /transl_table=11
                     /translation="MAEPLKNMYTENFLQLFGEKVQSAYRPFDTNGFIHQVMDEKWDEL
                     ELKERIRRISFTLGAFLPSNYEEALDILFAIDEHCSGFPYLFFPDFVEVYGQGEEHWGL
                     SMKALERFTSKSSAEFAVRPFLLREPERMMRQMTAWAGHQSEHVRRLASEGCRPRLPWG
                     QALPVFKRDPAPVLAVLELLKADPSLYVRKSVANNLNDIAKDHPDVVIATAQRWKGIHP
                     DTDWIVRHGCRTLIRKSIPEVMAMFGYADETDGAPLVTDASFSTDPALLRLGDNCELSY
                     ALQLREGDPVRVRIEYGIDFVKARGQVSRKLFLLSDKTVPGGTRLTGTRTHRFADLTTR
                     RHYAGAHRIALLVNGQEAAFTMVELQL"
     gene            11695..13284
                     /locus_tag="C1T21_RS25110"
                     /old_locus_tag="C1T21_25115"
     CDS             11695..13284
                     /NRPS_PKS="Domain: AMP-binding (22-427). E-value: 4.6e-87.
                     Score: 284.2. Matches aSDomain:
                     nrpspksdomains_C1T21_RS25110_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017428564.1"
                     /locus_tag="C1T21_RS25110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25115"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_103050191.1"
                     /sec_met_domain="AMP-binding (E-value: 9.3e-99, bitscore:
                     320.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDQQQWLAPEYYNMTSEMEHHDAGKTALKWLSETGEYEEITYGE
                     LLKKANRLAGGLANLGFNKGDRVLVVVPRRIIAYVIYLACLKLGLAVIPSSEMLRAKDI
                     AYRLRHSEARAVIAWTGVTSEVDKINDDLPALDYRIVVSGDDTADVSGWLVLNELMDGQ
                     GDTFEAVKTHRDDMAILAYTSGTTGNPKGVVHSHGWGYAHLRITSPWLDIQASDIVWAT
                     AAPGWQKWIWSPFLSVLGNGATGFVYNGPFRPGRYLQFIQQYGIQVLCCTPTEYRIMAK
                     TDGLDQYDLSQLRSAVSAGEPLNQEVINKFQEQFNITIRDGYGQTESTLIIGNLKDAPL
                     RTGSMGKSIAPGLVEVVDEDGIPLAPGQVGDIAVRADLPALFHTYYHDPERKLASVHGD
                     YFVTGDRARKDEDGYFWFEGRGDDIIISSGYTIGPFEVEEALMKHDSVQECAAVASPDE
                     IRGHVVKAFVVLKAGVEGSPALVKELQHHVKTWTAPYKYPRKIEFIQELPKTSSGKIRR
                     VELREMEKQSVL"
     aSDomain        11761..12975
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C1T21_RS25110_AMP-binding.1"
                     /evalue="4.60E-87"
                     /label="C1T21_RS25110_AMP-binding.1"
                     /locus_tag="C1T21_RS25110"
                     /protein_end="427"
                     /protein_start="22"
                     /score="284.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DAGKTALKWLSETGEYEEITYGELLKKANRLAGGLANLGFNKGDR
                     VLVVVPRRIIAYVIYLACLKLGLAVIPSSEMLRAKDIAYRLRHSEARAVIAWTGVTSEV
                     DKINDDLPALDYRIVVSGDDTADVSGWLVLNELMDGQGDTFEAVKTHRDDMAILAYTSG
                     TTGNPKGVVHSHGWGYAHLRITSPWLDIQASDIVWATAAPGWQKWIWSPFLSVLGNGAT
                     GFVYNGPFRPGRYLQFIQQYGIQVLCCTPTEYRIMAKTDGLDQYDLSQLRSAVSAGEPL
                     NQEVINKFQEQFNITIRDGYGQTESTLIIGNLKDAPLRTGSMGKSIAPGLVEVVDEDGI
                     PLAPGQVGDIAVRADLPALFHTYYHDPERKLASVHGDYFVTGDRARKDEDGYFWFEGRG
                     DDIIIS"
     CDS_motif       12226..12285
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25110_0001"
                     /evalue="1.00E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="C1T21_RS25110"
                     /protein_end="197"
                     /protein_start="177"
                     /score="24.3"
                     /tool="antismash"
                     /translation="AILAYTSGTTGNPKGVVHSH"
     CDS_motif       13090..13137
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C1T21_RS25110_0002"
                     /evalue="7.00E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="C1T21_RS25110"
                     /protein_end="481"
                     /protein_start="465"
                     /score="-2.5"
                     /tool="antismash"
                     /translation="AFVVLKAGVEGSPALV"
     gene            13332..14564
                     /locus_tag="C1T21_RS25115"
                     /old_locus_tag="C1T21_25120"
     CDS             13332..14564
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014281878.1"
                     /locus_tag="C1T21_RS25115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25120"
                     /product="aminopeptidase"
                     /protein_id="WP_103050199.1"
                     /transl_table=11
                     /translation="MSTFESLLEQYAELVVRVGVNIQPGQVFLVTAPLETVEFTRLIVS
                     KAYEAGAKYVQVEFEDDSITRSRFEHGDEASFDYYPAWKAEMMERFAEEGGATLTIKVP
                     NPDLYQGIDPQKVSRATKAAATAREGFSKYTRNHKISWCLIKAPTKAWADKVFADVAEE
                     DRIGVMWDTIFQMNRVDGSDPIQNWQKHLKNLEQVQDKLNHKKYKSLHYRAPGTDLRIE
                     LADGHIWRSGGGENERGDYFVANMPTEEVFTMPKRTGVNGHVTSTMPLNLNGQLVDRIT
                     FTFKDGKVTEYTAESGEQHLTHLLATDEGASYLGEVALVPHDSPISNLNRIFYNTGIDE
                     NASCHLALGSAYPFNMENGTQMNREELLQNGANVSLTHVDFMIGSAELDIDGELQDGSK
                     EAVFRKGNWAI"
     gene            14793..15383
                     /locus_tag="C1T21_RS25120"
                     /old_locus_tag="C1T21_25125"
     CDS             14793..15383
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371114.1"
                     /locus_tag="C1T21_RS25120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25125"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_023988547.1"
                     /transl_table=11
                     /translation="MNHPDKKQQTKEKILDATLEFIQKEGFEAVTIRKIADLSATNISL
                     VNYYFGSKENLLSEAIEVILNGFQHTFSILDNTAMPPQDRLKQFLLNYLQVIRQYPELL
                     SRIIAMGSTPFTSQQEYGRFLNIMGFPKVQSTIKELTGEQQPERLLAMMLQIFGAIFLP
                     ALMSPILESGAVVEIPSIEEQLNLLFERYFDQK"
     gene            15402..16028
                     /locus_tag="C1T21_RS25125"
                     /old_locus_tag="C1T21_25130"
     CDS             15402..16028
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017428567.1"
                     /locus_tag="C1T21_RS25125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25130"
                     /product="HXXEE domain-containing protein"
                     /protein_id="WP_103050192.1"
                     /transl_table=11
                     /translation="MNFLRKYWQDAGAIIGVVVCIVLLMNPAILSDITGMLWLSFVAIL
                     FHQFEEYRWPGYFAGLFNNVMFKSDTPDHYPLNTQSAMIINVAIAYVFYLLPVWFPQVV
                     WLGLAPVFMGFFQVVWHGIVVNIKAKTLYNPGLFTALLLHVPVGIWYIHEIVQRDLPTA
                     IDWIAGTIYFVFAVYIFIIKGNIWLKKSDSPYSFSKQQLGAYGRK"
     misc_feature    15406..15419
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 24.02"
                     /tool="antismash"
     misc_feature    15407..15421
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.21"
                     /tool="antismash"
     gene            16148..16843
                     /locus_tag="C1T21_RS25130"
                     /old_locus_tag="C1T21_25135"
     CDS             16148..16843
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819039.1"
                     /locus_tag="C1T21_RS25130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25135"
                     /product="DUF4309 domain-containing protein"
                     /protein_id="WP_103050193.1"
                     /transl_table=11
                     /translation="MKDTHQSHDRKKLAYKLITTSALLAIGFAVMTGCSNSGEEKSTAP
                     TKAETVTPPASSTDQNTDLNTKGQGSTSTHQEPASSTASSHSKHSSVAAIFIAAKQGTL
                     PNLPKGLGLGTSSDLLFELWGKSDSGSTGPMRSYAKYHTDIMLDGSDKVTEITSTDPDY
                     KKLLIKQVVDELGQPTETVDTSKDIPDTAEANYTINNTSGLSYYLVFSYQTKTQKVNYI
                     RLYFNSKTP"
     misc_feature    16979..16999
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.65"
                     /tool="antismash"
     gene            16983..17510
                     /locus_tag="C1T21_RS25135"
                     /old_locus_tag="C1T21_25140"
     CDS             16983..17510
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819040.1"
                     /locus_tag="C1T21_RS25135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25140"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_103050194.1"
                     /transl_table=11
                     /translation="MAKATSTSINRQKEIISAAIEVFAEMGYYRATTAKVAERANISQP
                     YVFRFFATKEALLVEALKVSFTRIIDSFHRVIHSASSEQLEQELIAAYSQIMMEYRNET
                     LLQMQAQTIREDEVVSVMQQGFREIHTTVYDAFRRAGIEQAMERTMLFLARGMLCNISM
                     SLDLPELMKKDD"
     misc_feature    complement(17648..17664)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.56"
                     /tool="antismash"
     misc_feature    complement(17698..17707)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            17723..18313
                     /locus_tag="C1T21_RS25140"
                     /old_locus_tag="C1T21_25145"
     CDS             17723..18313
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1163: rhodanese domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013310302.1"
                     /locus_tag="C1T21_RS25140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25145"
                     /product="sulfurtransferase TusA family protein"
                     /protein_id="WP_103050195.1"
                     /transl_table=11
                     /translation="MSSTNNIQADHILDCKGLACPMPIVKTKKAMNELVPGKIMEVQAT
                     DKGSLADFQSWAKNTGHQYLGTLQEGDVMRHYLRKANPAEVKKEQIFSSTISHEELQAK
                     CSGKENFILLDVREPAEFALKYIPGSKHIPLGELENRLSELNLEEEIAVICQAGARSEM
                     ACQLLVSKGAKKVKSVLSGISEWAGETKGSESI"
     gene            18310..18825
                     /locus_tag="C1T21_RS25145"
                     /old_locus_tag="C1T21_25150"
     CDS             18310..18825
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819042.1"
                     /locus_tag="C1T21_RS25145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25150"
                     /product="DsrE/DsrF/DrsH-like family protein"
                     /protein_id="WP_103050196.1"
                     /transl_table=11
                     /translation="MSTTAGIYANNQEHAQSKTTIVLFSGELDKAIAAFIIANGAAAYD
                     HEVTIFFTFWGLNTLRKDEIVSTNKGILEKAFGWIMPRGPQKLALSKMNFAGLGPQMIK
                     HVMKKHKALSLPELIELAREQGIKLVACTMTMDLLGLQQDELIDGLEYAGVAAYLGDAS
                     QGKVNLFI"
     gene            18902..19168
                     /locus_tag="C1T21_RS25150"
                     /old_locus_tag="C1T21_25155"
     CDS             18902..19168
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819043.1"
                     /locus_tag="C1T21_RS25150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25155"
                     /product="metal-sensitive transcriptional regulator"
                     /protein_id="WP_013310304.1"
                     /transl_table=11
                     /translation="MDYNYSDELKTRLRRIEGQVRGVLRLMDEGKSCKDVVSQLSAVRN
                     ASDKAIAQIVAENLQRCILEEQEAGGDTDKLVKEAIQLLVKSR"
     gene            19458..20171
                     /locus_tag="C1T21_RS25155"
                     /old_locus_tag="C1T21_25160"
     CDS             19458..20171
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007130313.1"
                     /locus_tag="C1T21_RS25155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25160"
                     /product="DUF421 domain-containing protein"
                     /protein_id="WP_103050197.1"
                     /transl_table=11
                     /translation="MEVFVTIGVKLIISFFGLWIITFITGRKTLSQLTPLDFLTSLVLS
                     EIVGNMLYDDKVTIGQLLFALALWCALAYFFEKAMTRFVKFGYMAEGRTVLLVDKGQVN
                     QEMLEKYDIEFTQLLSMLRQQNIFSLREVWYATLETNGSLSVMRKPEYEPPAAQDMGID
                     AQPDLFSVTVIDKGKLLNESMRGKSIDIEEIKAKVREQGYDSIDEIAYAEFSEDGTLHV
                     VPMNENKHQKSGGSI"
     misc_feature    20567..20581
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.21"
                     /tool="antismash"
     gene            20591..21751
                     /locus_tag="C1T21_RS25165"
                     /old_locus_tag="C1T21_25170"
     CDS             20591..21751
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017428575.1"
                     /locus_tag="C1T21_RS25165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_25170"
                     /product="PLP-dependent aspartate aminotransferase family
                     protein"
                     /protein_id="WP_103050200.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.1e-08,
                     bitscore: 24.8, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFSDDQLICLRFEDELGYFAKAAAPPIYETAPFFFDTYEDYAEA
                     ANNEKEHYVYSRGTNPTVQIAEQMIAALEGGADCKCFASGMAAISAALMCSLSAGDHLI
                     LVGHIYETSVSLARYLKRFHIDYTIVHSTSTEAVAGAIKPQTRAILMESPTSFTFDMVN
                     VQEVTSLSKAKGIRTIIDNSWATPLFQKPLEWGVDIVVHSASKYLGGHNDLIAGAVIAS
                     KEIINRMYAEEYELIGGSLGPFEAWLLIRGLRTLPLRMEAHQRNALLVARFLTDHPAIS
                     KVNHPGLPSHPQHELACRQLKGYAGLFSFELKDSTYEDICKVINKLRLIRIGVSWGSME
                     SQVISPNYGFNKQSLKKQHMPESLIRLAVGHEPAELLIQDLATALS"
ORIGIN
        1 tggcgccagt gggtgtagct ggagaactgt gtgtatcagg tgtaggactg gcacgtggat
       61 atctgcatcg tcccgaactg acgaaggaga aatttatacc gaatccgttt acggatggag
      121 aaaccggata tgaacggatg taccggacag gggacttggc gagatggatg ccggannnnn
      181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna ccttcatact
      421 ttgtacagct ggagtccatg ccactgacac cgaacggcaa aatagaccgc aaagcactgc
      481 cattgccgga attagcgaat agcccggatg caggctacgt agctccaaga aatgaaatgg
      541 agcagcaatt ggcgaatctc tggcagacgg tgcttggtag agaaaaggta agtatcgacg
      601 agaacttctt tgaacttgga ggtcattctt taaaggcgat tcagctcgtc accaaagcac
      661 aagaatcagg tattccattg ggcatacacc aagtgttgca acatcaaacc attcgaagct
      721 tgtccgatct gttatccctt aataaagttg ccaccaagca agacacttca ttgcttacag
      781 atttaacgga agctgaacaa tggattagcg aaacctttgg agtacaggct atgcttcaat
      841 tcgtagccaa cgatgagcac gactatttat ttttacaaat atatccgttc cgaccagatc
      901 aggtgagtga aatgaccgtg ggaatttcgt ctcatattca ttctgaactg caccctcact
      961 atatcgttcc tatgggtgag gaagacgcca gccagtgggt cagcacagag tatacagagc
     1021 tggagcagac agacgaggaa caggcaaaca gccgtcagcg tccgttggag tctgaggaat
     1081 ggattataaa aatcgctaaa atgaatgctc gctggaataa gtatctactc agctcaaagg
     1141 ttatctatcg tttcccgctg gcccctgctc agcattatca tttggtgcac ccggcttcct
     1201 cgggtaccgt gatccggctg gatcaatacg tggatgtgga gcgcctgact acagcagttc
     1261 gacagttgat tcaacgtcat gaattactga gaagtgtgct tgtatgttcg gatggaatat
     1321 gggaatggga agtacggcca actccagagc atatttcatt gccttgtgtg gatctttcag
     1381 tctatcctgt gcaggaacaa caacagcttc ttccatccat catgtcgaat ctgtattttg
     1441 aaccatatga gcagacccaa tctttgcagt accggattac gctggttcgc ttgaatctgc
     1501 gggaacactt gctgctgctg ccatgttcac acattatttt tgatgctacg agcagtgtag
     1561 ttctgcataa tcagcttctt gaggaatacg atcataccca gcagagtcag accgttaaaa
     1621 cattccatta tcacgattat gtcgatctta tccgccaagg tcctcaagga atcagtgatc
     1681 aagacattgt ggagcaattt aagctccaag cgtttgacaa taacaatagc cgaatccatg
     1741 caaggatgcg tgagtgtaac tatgcacaat ctacctcatt gatttgggaa ctgaagctgc
     1801 atgatattca aaaacaggac gtggctgcaa gcctgtcgga tatttcgttg caaattggat
     1861 ttcagttctt tagccgttac tttgaacagt ctgaagttcc gttatggtta acgcagtatg
     1921 gacgacagta tggggctagg aactactttg ggtcactggg agaatatatt gaccatattc
     1981 ctgttttact ccagaaggaa gaggagatat cctacgaaaa cgatattcag aaacccttgg
     2041 atgttgctgt gaatcaccat ttaaatttct ttaatttgat ctttaacgaa gaaatgaaat
     2101 cagtttaccc gcaatcaagc agcattctaa aaaagaattt tgaacaatta cctattgtgt
     2161 tcaactactt gggtgaaatg aaggaagact cgaagttgct cggtgctttg aataggccga
     2221 aaaaagaggc taatggaggc ggagccattt tcttcgagtc tgcgtataca gcaagtgttc
     2281 tgaaaatttc tctgtccctt ccgtatgagg aagattgcga ggaaatttat caaattttcc
     2341 aagctgcaac tgaaaaggtt ctgttgaatc tgaccatacc gcagtaagga actgaagata
     2401 tactttttat ctgagaattt tgcaaatgcc ggatctataa aaatcttatc cttcccctct
     2461 ctcgtgaaag taaccaaaat aacgatgctt tcaggttctt gacgaccgag agaggggatt
     2521 ttttatttct gaattaaaat tgctcctgag atgtatgcaa attgtgttgc catatctttg
     2581 tggggaggaa aggggtttgg tatgaatcgc acagccttgg tttttccggg acaagggtct
     2641 cagtatgtag ggatgggagc ggcatggcat agcggtttta cagaagcaga tcgcttgttc
     2701 gaagaggctg ctgatatttt gggatatgat ctgaaagctt tatgcatggc aggtccgatt
     2761 acccagctat ccagaacatt ttatactcag cccgcacttc ttacgatcag cgtcattgcc
     2821 ttccggcgtt atatgcacga aatcgggatt atccctgaat tttcagcagg tcatagcctg
     2881 ggtgaatatt cagctctggt aagtagcggt gttctatcct ttggcgacgc tttacggctg
     2941 gttcaagagc ggggacgctt catggaagaa gccgcagtgg ccggactggg cagcatgatt
     3001 gccgttcgcg gagctgagcc aggcgctgtg gaagaattct gtcgtttgca ctccacagta
     3061 gatcagcctg ctgccattgc ctgttacaat tcacctaacc agtacgtcgt ttcaggtcat
     3121 agcacctctg tcgctgtggt agctggcgag ttagaacagc ggggagccca aattacccgc
     3181 ttgcaggtca gcggtccttt tcatagtccg cttatgcagc ctgctgcgga taggctgacc
     3241 gcagagctgc aaaaatacac tttaaatgag gcgaagtggc ccgtgatctc taatgtgacc
     3301 gctcagccat accccgatgt tgacagcatc cgccaaggat tgattttgca aatgactcac
     3361 ccagttcgat ggattcaaac catgcagtat atggcgaatc atggcgtgaa acaaggcatc
     3421 gagttaggtc cacgaacggt gctgaaaaat ttgacgaagg aaataaacac ttccattgaa
     3481 ttgctgtccc tcgacagaga cttggatcgc gttgaactgg aacgccgttt ctcaatccgt
     3541 gattgggttg ctcgttccct ttcactggcg gtgtctaccc ccaatgccaa ttggaatgaa
     3601 gatgagtatc gaaagggtgt tattttacct gttcgaagac tggaagaatt actgcgaaac
     3661 tcagaatcag acagcagtcc gcctcctgct tctgagcaaa gacaggaaat actggggtgt
     3721 attcgcctag tgttgcaaac caaacaggtc tccgaaggag agcagaaagt aatgctagag
     3781 caattaagga gggatcagga tggagcagtt tcaaacttta attgaaatca ttcaagaccg
     3841 cgcaaaccgg gatgaacacg ggatcacctt tatttccggt gataaacaag aggaatatgt
     3901 ctcctacagt aaacttctgg agcaagcatt acaggtactt catgaattac aggaaaaagg
     3961 gattcaacct ggtgatgagc tgatcatgca gatcgacgac aatcatactt ttgtgaatgt
     4021 attttggggt tgcctactcg gtggaatcgt acctgttcct gtaagcatag ggaataatga
     4081 tgagcataaa atgaaattgt ttaaaatctg gaatacactc tcctgtcctt atatgattgc
     4141 agatgacaag gtattggagc agttggaaaa atactcgcac caacaccaac tgctggattc
     4201 ctttgagcct gttaaaaaag cgactttttc aagccataca ttcgattatt ccaatcagag
     4261 taaaggtgta gtccatatat ccaaaccgga ggatttagct tttatccaat tttcctcagg
     4321 ttctacaggt gatcccaaag gtgtcatgct gacgcatgaa aatttgattt acaatattcg
     4381 ggatatcgca aatcaaacag gcatgagctc caaggatgct tatttaggct ggatgccgct
     4441 tacgcatgac ctgggattga tcgcatttca tttaacctgt gtgatcgcta atgccaagca
     4501 gctgattatg ccgacggcac tttttatcag acgtccgtct ttatggttaa aaaaagtatc
     4561 ggagcataag gtgactcaaa tatgctctcc caatttcgga tataaatttt ttctcgatca
     4621 gtataaacct gaaacagcat ctaactggga tttgtcaagt gttcgtatga tcttaaatgg
     4681 agctgagcca gtatctgtgg agctttgtca tgtgtttatg gatgcaatga gtgttcatgg
     4741 tttgaataaa aatgtgatgt tccctgtcta cggtttggca gaagccagcg taggtgtttc
     4801 cactccacct ctggacaagg ataccttttt acccatccat ttgaatcggc agcagttaca
     4861 cgtaggtgaa cccatcgaag aagtagacaa gtccgacaag cggtgtctta cttttgttga
     4921 tttggggtat ccaatggcca gtacctctgt ccgcatttgc gatgatcaaa atcaggtgct
     4981 cgaagatggg gtgattggac acacacagat ctgcggcaaa aatgtgacgt ccggatatta
     5041 taacaatcca gaggctaccg cgaaggtcaa aacagaggat ggctggctta tcactggaga
     5101 tttagggttt atgcggaacg gccgcctgac tattaccggt agagccaagg atatcatttt
     5161 cgtgaacgga cagaatgtct acccgcatga catcgagagg attgccgagg aactggatgg
     5221 cgtggatctc gggaaagtag ctgtgtgcgg tgtacatgat gcgcaaacca ggcaggatcg
     5281 tattgttgcc tttgtgatgc acacgaaaaa gatagaacat tttgtaccgc ttgtccaaaa
     5341 gctgaaaagc catttgaatt accggggagg ttggtacatt caggatgtgg ttccgatccg
     5401 gcgtatccct aaaacaacca gtgggaaagt tcagcgcttc aaattagccc agagttatga
     5461 gcaaggtgaa tttaatgaaa tactgacaac tctggccgag gccactcaaa ccgtgccagc
     5521 agctgagcat aaaatcttgc ctcaaggaga gatagaacag aagctgattg gaatctgcca
     5581 ggatatttta aatgtaaagt cgatcgggac ggacgacagc tactttgata tcggagtgaa
     5641 ttccttgcaa ctcgttcaga ttgtggacct gttggaggac caattaggga ttcatattaa
     5701 ggtgacggac ttcttttcct atccgaccat cgccaagctg gctgcgtata tctccagtca
     5761 ggacctaagc agtgaagcgg ctgcaacagc acagcctgag gccaaggaga aagtgaatga
     5821 ccgggatatt gccatcatcg gcatgtccgg caaatttcct caagcggaaa cactggagca
     5881 gttttgggcg aatatggcat caggggcaga caatatcgga ccgtacagtg acgaaagaag
     5941 gaaagacgcc gaagatttca tttcccgtct gaatacggaa ggacggaata tgcaaattgc
     6001 agaaggcggc tatctggatg aagtagacaa gttcgattac tccttcttta agctgactcc
     6061 acgggaagcc tcactcatgg acccgaatca acggttattc ctacaaaccg cctggagcac
     6121 gatcgaggat gcggggtatg gggggaagca actggcgggt caaaaggtcg gcgtgtatgt
     6181 cggcttctcc aaaaccagct tcgaatacga gcgtttgttg tccgaggtgg aaccgggggc
     6241 actgccgaac tttgccattg gtaatttatc gtccattatt tccagtcgga ttgcatattt
     6301 actcgatcta aagggtccgg cgctaaccat tgatacagct tgttcttcct cactcgtggc
     6361 agtgcatttg gcctgcaagt ccatccttag tggagactgc gacatggcct tggcaggtgg
     6421 agtgaagacg attttgctgc cactgaaagc gggtattggc atggaatcct ctgatgatcg
     6481 ggcacgagcc ttcgacgacc agtcggacgg aacgggctgg ggagaaggag ttggagccgt
     6541 tttcctgaag ccactgcgca aagcggaaca agacggtgat aacattttag ccgtgatcaa
     6601 aggaagtgcc atcaatcagg acggcagcac gattggtatt tccgcgccga atgcgctggc
     6661 tcaggcagaa gtaattttgc aggcgtggcg tgatgcacgg attaatcctg aaacgatcag
     6721 ctatatcgaa gcgcatggca ccggaaccaa actgggcgat ccggttgaga ttgacggcat
     6781 taccaaggct ttccgcaagc atacacagcg taagcagttt gtcgcaatca gcacagtcaa
     6841 aacgaatatc ggtcatttat acgaagccgc cgggattgcg ggcttgatca aatccgtact
     6901 gtccttgaaa tatcaacaga ttgcgccgct cgttcatttt cgtgcaccaa accagaaaat
     6961 ccattttgaa gaatccccgg tatatgccaa tacgaagctg agggaatgga agacggatgg
     7021 tttcccgaga agaagtggac tgagctcctt tggattcagc gggacaaact gccatgtggt
     7081 gctggaggaa tatatagcga agacggaatc agaccaaact tcaacggaca gtaacaatag
     7141 atcatcaccg ctgctgctga ccttgtcagc gcggagtgaa tccgctttgc gagagctggt
     7201 cgggcggtac gcagaacggt tcagacgcgg agaagaactc gtgatacagg atgtatgcta
     7261 tacggctaac acaggcagag ggcacctgaa tcaccggatt gctatgactg ccgcaggagg
     7321 ggattcgctg aaagcgaagg tgtttcagtt acacgaacaa ggcagagtcg tcgaaggcgt
     7381 atacaccggg gaagctgata gcacaggtag tgcagagata gtcactggaa gcttggacac
     7441 gttgcaatca ttggagcagc tggcagccaa gtacgtgcaa ggagcgcaga tcaattggaa
     7501 tgccctctat gcaggtaagc actataaaaa ggtttcgctg cccacgtatc cattcgaacg
     7561 taaaagatgc tgggttaacg tgcctgaaca ggttcgaacg gaacagaagg ccacagttca
     7621 atctgtgcaa aatcgtccag aaacatccct gaatcaggtt gatcatgcag ctttcccgtt
     7681 aacccaaccg tctcatgaat caaccgttcc ggctggcgct tccgtctatg ctatggatac
     7741 cgctgggcaa atacggactc aaagcgtccc gaacgctaca gcttctgcgg ttgtagagcg
     7801 aattttggag caacagttgc gtctgatgtc acagcagctc gatgttctcc ggggtcagtc
     7861 atctccatcc gtaaagtctg tttccaagaa tgtaggaaat cactgaagca gagctacgtc
     7921 ggtttgccag ggaaatcatc ctgtgctgcg gcgagagatt cccagtacga tttgatagca
     7981 ggggccgaac ctacgagatg gatctactat tcctattagg gcttcctcca tttctcctat
     8041 ttttcagcta taactgatag cgaatcatta ccttctctca tgaaaacaac ccattcagcg
     8101 gtgttttcgg gtccatagcg actgagagag ggtcttttga gttatataca aattgacagt
     8161 gatacataaa aagagtaacg taactgtata tttattaaaa tcatataaaa ttaatcggat
     8221 taattaaatg tgaagttgtt gtgatctgat gatataagga ggaatttttt tgagtaactc
     8281 gcaatttagc atggccaaac gccgtataac agccgaggat ttatatcgac ttcattgggt
     8341 tagcgatcca gctgttcatc ctattagtgg tgaaatcgct tacgtagaac agtatattaa
     8401 tgaagagcac acagactata actcgggtat ttggctgttg ccattccaag gtgatgctcc
     8461 gatacccttt acatacggac cgaaagatga aacgcctgtt tggtcaccgg acggatcaca
     8521 acttgctttt ctccgtacga cagacggcaa gcgtcaggta tggattattc cagcacgcgg
     8581 gggagaggct cgacagctta cacatgtaga gaacaacgtt cgttcactag cctggtcgcc
     8641 ggatggggcc tgcatatcgt ttgtagctaa gacggctgag aaccagtcaa gccctacatc
     8701 cgatacagga aatcaggagg cacaacttaa gggacgagtc gtaaatcgaa caaaagctaa
     8761 atctgacggt tatgggctgt gggatgatac tcgtgatcac ttgtatgtaa ctgatgtgac
     8821 ttcggggcac acagttcaac tgacgtccgg tgcttatgat gtggcggagc ctgtgtggtc
     8881 accggatggt caacgtattt tattcgtcgc caggatagca gagcattcga aagaggatat
     8941 ggatttacgt aagcaaaatg atttgtttac gatagctcct gcgatttcaa atggtgatgc
     9001 agcagcaccg cttaagttga cccattctaa actgcacatc gagagtgctg cttattctcc
     9061 cgacggttca acgattgcct tttacggtca tgatcgacat gccaaagatg ctacacagac
     9121 tcgactgtac acgattccct ccagtggcgg gacggcagta tgcgtcagtg agacgcttga
     9181 cgctcacttc ggtaatgcgg ggatgagcga catgcgttca caccttcata tagggccacc
     9241 acgcttcagc gcggacagtc aatctctata tacgctggta actcttgaag ggaatgtaca
     9301 cgtatatcag tttgcgcttg atggaacttt taaaatttta acccaaggag agcgggaaat
     9361 ttatcaattt gatcttactt cagatgagca gcatatcatt gccgcttcca ccgatgtcgc
     9421 tttaccaggc gatttgttcc ggattgcgat ccattcagga accgatgaac ggctgacacg
     9481 agtgaatgac tctctgcttg atgagattga aattagtatg cctgagagct tctggactga
     9541 ggtcgaggat ggtcgacggg tgcaggggtg ggtgatgaag cctgttggtt ttaaggaggg
     9601 agtatcctat cctgccattt tggagattca tggtggtccc catgccatgt attctaattc
     9661 cttttttcat gaatttcagc tgctggccgc tcagggatac gcagtcattt acacgaaccc
     9721 gggaggaagc cgagggtatg gacagtcttt caccaatgtc gtccttggag attacggcgg
     9781 acgcgattac accgatctgc tgagcgcagt ggacgaggct atacgtcaat ttccattcat
     9841 tcatccggaa aggctgggtg taacaggagg cagctatggt ggatttatga caaactggat
     9901 tgtcggccat accgatcgtt tccgcgcagc tgtgacccag cgctccatat ccaactggct
     9961 gtcgatgtat ggggtgagtg acataggata ctcgtttact gaagatgaag tcggcgggaa
    10021 tccgtgggag gattgcgagc tcttgtggaa gcaatctccg ctggcttatg tgcagcaaat
    10081 caacacaccg ctgctcatat tgcacgggga gcaggatctg cgatgtccta tagagcaggg
    10141 agagcagctg tttacagcat tacggagatt ggggaaacct acgcaatttg tccgttttcc
    10201 agcttcaagt catgagcttt cacgaaaagg gcacccgcag cttcgtgtgg aacgcctgca
    10261 acgtattacc aattggtttg ccgagcacga aatataagtt ctaaacgatt ttatccgtta
    10321 ttgaaaaaat gtcaggtcct aatcatagga cttggcattt ttagtatgcc ttgctacaat
    10381 tctctcaact tcatacaaaa ggagatatat aatggccgag cccttaaaaa atatgtacac
    10441 ggagaatttt cttcaactat tcggtgaaaa agtacagtct gcgtacaggc cgttcgatac
    10501 caacggattc atccatcaag tgatggatga aaaatgggat gaactggagc taaaagaacg
    10561 aatacggcgt atttcgttta cattaggggc atttttgcct agcaattatg aagaagctct
    10621 ggatattctt tttgctatag acgagcattg cagtggtttt ccgtacttgt tttttcccga
    10681 ttttgtggag gtgtatgggc agggagaaga gcattggggc ctgtccatga aggcactgga
    10741 gcgattcacc tctaagtcct ctgcggagtt cgcagtgaga cccttcctcc tgcgtgaacc
    10801 ggaacggatg atgcggcaga tgacggcctg ggcgggacac caaagtgaac acgtccgccg
    10861 tcttgccagc gaaggctgtc gtccacggct accctgggga caggcattgc ctgtgtttaa
    10921 gcgtgatcct gctccagttt tggccgtatt ggaactactg aaggcggatc cttcactata
    10981 tgtacgtaaa agtgtagcca acaacctgaa cgatattgcc aaggatcatc ctgatgtggt
    11041 cattgctacg gctcaacggt ggaaagggat acatcctgac accgactgga ttgtacgtca
    11101 tggctgtcgg accctaattc gcaaatccat acccgaagtg atggcaatgt ttggctatgc
    11161 ggatgaaaca gacggggcgc cgttagtcac tgatgcctct ttcagcacag accctgcctt
    11221 gctaaggctc ggtgataact gtgagttgag ctacgcgctt cagcttcgag aaggtgaccc
    11281 agtacgagtc cgtatcgagt acggcatcga ttttgtgaag gcgagaggac aagtctcacg
    11341 taaactgttt ttgctatctg acaaaacggt ccccggagga acccgtctta caggtacacg
    11401 gacacaccgc tttgcagacc tgacaactcg tcgccattat gcgggagcgc atcggattgc
    11461 gctgctcgta aacgggcagg aagcagcttt tacaatggta gaactccagt tgtagaatca
    11521 cgatagcggt aaagaaaaag agcctgaaat caggctcttt atttttatcg ttcgctttac
    11581 ccaaatttat ctttttccaa aaaaatgatt ctggtattag aacctggtac taagacatgt
    11641 tatactacag taagaaagtg gatctcatct tatgtataaa ggggaaggta taatttgaca
    11701 gatcaacaac aatggcttgc gcctgaatat tacaatatga cttcggaaat ggaacaccat
    11761 gatgctggta aaactgcact caagtggctg agtgagacag gagaatacga agaaatcacc
    11821 tacggagagc tgttgaaaaa ggctaaccga ctggctggag gactcgcaaa tctgggattt
    11881 aacaaaggtg acagggttct ggtcgtagta ccacggcgta ttattgcgta tgtaatttat
    11941 ctggcctgct tgaagctggg gcttgctgtc attccatctt cagaaatgct acgtgccaag
    12001 gatattgcat atcgtcttcg ccattcggaa gcgcgcgcag tcattgcctg gacgggagta
    12061 acaagcgaag tggacaaaat aaatgatgat ctgcctgctc tggattatcg tatcgtagtc
    12121 tccggggacg acacggcaga tgtatctggt tggctcgtgc tgaatgaact gatggatgga
    12181 cagggagata cttttgaagc tgtgaagacg caccgtgacg acatggccat tctggcctat
    12241 acttcgggca ccacgggaaa tcctaaaggt gtagtacata gccatggctg gggatatgct
    12301 catctgcgga taacatcacc atggttggat attcaagctt cagatatagt atgggctaca
    12361 gctgcaccgg gatggcaaaa gtggatttgg agtccgtttt tatccgtact gggaaatgga
    12421 gcgaccggat tcgtatataa tggtccgttt cgtccaggtc gctatttgca gttcatacag
    12481 cagtatggaa tccaagtgtt atgctgtacg ccgacagaat atcggattat ggcgaaaacg
    12541 gatggtttgg atcaatatga tctatcccaa ttgcgcagcg cagtttcagc gggagagcct
    12601 ctcaatcagg aggtcattaa taagtttcag gagcagttca acattacgat tcgtgacggc
    12661 tacggtcaaa cagagagcac attaattatt ggtaatttaa aggatgcacc tctgcgtaca
    12721 ggctcgatgg gcaaatccat tgcaccggga ctcgttgagg tcgtagacga ggatggcatt
    12781 ccgctggctc cggggcaagt gggggatatt gcagtacgtg ccgatctgcc ggcattattc
    12841 catacgtatt accatgatcc agaacgcaaa ttagctagtg tccacggaga ttattttgtt
    12901 acgggagacc gggctcgcaa agatgaggat ggatatttct ggttcgaagg acgtggtgat
    12961 gatatcatta tcagttctgg ctataccatt ggtccttttg aagtagagga agcgcttatg
    13021 aagcatgact ccgtgcagga atgtgctgcc gtagccagcc ctgacgaaat ccgtggacat
    13081 gttgtaaaag cttttgtcgt actcaaagct ggggtagaag gatcaccggc gttagtgaag
    13141 gaactgcaac atcatgtgaa aacatggacg gcgccttata aatatccacg aaaaatagag
    13201 tttattcaag agcttcctaa aactagctcg ggcaaaatac gaagagtgga gctacgtgaa
    13261 atggagaagc aatccgtact gtagtgatga aatcattcaa tataatcaaa acggaacagg
    13321 agcgcggaaa aatgagtaca tttgaatcat tgttggagca atacgcagaa ctggtcgtaa
    13381 gagtaggggt taacattcag cccggacagg tgtttttggt aactgcaccg ctggaaactg
    13441 ttgagtttac acgcctgatt gtcagcaaag cctatgaagc aggcgctaaa tatgtacagg
    13501 tagagttcga ggatgattcc attacacgta gtcgttttga acatggtgac gaagccagct
    13561 ttgattacta ccctgcttgg aaggcagaaa tgatggagag atttgccgaa gagggtggag
    13621 ccacactaac gattaaagtg ccgaacccgg atttatatca aggcattgat ccacaaaagg
    13681 tttctcgtgc gactaaggcg gcggctacgg cgagagaagg tttttccaaa tatacccgaa
    13741 atcataaaat tagctggtgt ttgattaaag cgccgacgaa ggcttgggcc gataaagtat
    13801 ttgcagatgt agcagaagag gatcgtatag gtgtcatgtg ggatacaatc ttccaaatga
    13861 atcgtgtaga tggctctgat cctattcaga attggcagaa acatttgaaa aaccttgaac
    13921 aggtacaaga caagctgaat cataaaaagt ataaaagcct ccattatcgt gcaccaggaa
    13981 cagatttgag gattgaactg gctgacgggc atatttggcg cagcggtggt ggtgagaacg
    14041 agcgcggaga ttactttgtc gcgaatatgc cgacagaaga agtgttcacg atgcctaagc
    14101 gtacaggtgt caatggtcat gtcacaagta ccatgccact caatttaaat ggacaactgg
    14161 tagatcgcat aacgtttacc tttaaggacg gtaaagtcac tgaatataca gcagaatccg
    14221 gcgagcaaca tctgactcat ttgctcgcta cggatgaagg ggccagctat ttgggagaag
    14281 ttgcactggt gccgcacgat tcaccgattt ccaatctcaa tcgcattttt tacaatacag
    14341 gtatcgacga aaatgcctcc tgccacttgg ctctaggcag tgcgtatcca tttaatatgg
    14401 aaaatgggac acaaatgaac cgggaggagc tgctccagaa cggtgccaat gtcagcctga
    14461 ctcatgtgga cttcatgatc ggctcagctg agctggatat tgacggcgaa ctgcaagacg
    14521 gaagcaaaga agccgtgttc cgcaaaggaa attgggctat ttaggccttt tctcaatctc
    14581 cattcaatcg acccgcaaac gatctcattc gttatgcggg tttttctatt ccctaaatct
    14641 cgaatcgctc cttgttttgt gaaataaaaa gtgctaaact gagttcaaac aataatttaa
    14701 acaacgtttt aattattgtt tgaaaagtta tttacataaa tcgtcccatt tcatttatcg
    14761 ttatgattgg acgaaacagg aggaggaaaa acatgaatca cccagacaaa aaacaacaaa
    14821 ccaaagaaaa aatcttagac gctacgctgg aatttattca aaaggaaggt tttgaggcgg
    14881 ttacaatcag aaaaattgcc gacctgtctg ctactaatat ttctttagtt aattattatt
    14941 ttggctccaa ggaaaatctg ctcagtgaag ctattgaagt gatattaaat ggctttcagc
    15001 acaccttttc tattttggac aatacagcga tgccccccca agatagactg aaacaatttt
    15061 tacttaacta tctacaggtc attcgtcaat atccagagct tctttcgcga attattgcca
    15121 tgggcagcac gccctttaca tctcaacagg aatacggaag gtttttaaac atcatgggat
    15181 ttccaaaggt tcagagcacg atcaaggagc tgacaggtga gcaacagccg gagcgcttgt
    15241 tagcaatgat gctgcaaata tttggagcta tttttctgcc tgcactgatg agtccgattc
    15301 ttgaatcagg ggcagttgtg gaaatacctt caatagagga acaattaaat ctgctgttcg
    15361 aaagatattt tgatcaaaaa taaatcatag gggtgactaa tatgaatttt ttaagaaaat
    15421 attggcaaga tgcaggggct ataatcggtg tggttgtatg tattgtttta cttatgaatc
    15481 cagctatcct ttcggatata acaggcatgt tatggttgag ttttgtagct atattatttc
    15541 atcaatttga ggagtaccgc tggcctggat attttgctgg tttatttaac aatgttatgt
    15601 ttaaaagtga tacaccggat cattacccct taaacactca atcagcgatg attatcaatg
    15661 tggcaattgc ctatgtgttt tatctgctcc ccgtatggtt cccgcaagta gtctggcttg
    15721 gactcgcacc agtttttatg ggattctttc aggtcgtctg gcacggcatc gttgtcaata
    15781 ttaaagcaaa aaccctatat aatcctggct tgtttacggc acttctcctg catgttccag
    15841 tcggaatctg gtatattcat gaaatagtac agcgagacct cccaacggca atagactgga
    15901 ttgcgggtac gatctacttt gtttttgcgg tatacatctt tatcattaaa gggaatatat
    15961 ggttgaagaa gagtgactct ccttactcct tttctaaaca acagctggga gcttatggtc
    16021 gtaaataggt atgttagaaa atcaccaatg tccttgttta caagttggaa acaagtagag
    16081 gtattccgga aacgaggttc ggttacactt ggtttgtacc caagaacaag gaaagagtga
    16141 tcttataatg aaggatacac atcaatctca tgatcgtaaa aagttggctt acaagctaat
    16201 caccactagt gctttattgg ctataggttt tgctgtaatg acaggatgca gcaatagcgg
    16261 ggaggaaaaa tcaactgctc ctactaaagc agaaacagtc acaccacctg ctagttctac
    16321 agatcaaaac acggatctca atactaaagg gcaaggctca acctctaccc atcaagaacc
    16381 tgccagtagt acagcttcat ctcacagtaa acacagttcc gtagccgcta tattcatcgc
    16441 agccaagcag gggaccttac cgaatttgcc taaaggtctt ggcttgggaa ctagtagcga
    16501 tttgttattt gagctgtggg ggaaatccga ttcaggttct acaggtccta tgagaagcta
    16561 cgctaagtat catacagaca tcatgctgga tggaagcgat aaagttacag aaattacatc
    16621 taccgatcca gactataaga agttgcttat caaacaagtt gttgacgaat tgggccaacc
    16681 tacggaaacc gttgatacct ctaaagacat acctgacaca gcagaagcta attatacgat
    16741 caacaacaca tcaggactta gttattattt agtgttttcc tatcaaacca aaacgcaaaa
    16801 ggtcaattat atccgattat attttaactc taagacgcca taattggatg tatgtaacag
    16861 agtcgtttcc gtcagaattg cggaggcgac tttattgcat ttttaggtta tgtcgtttat
    16921 actgatttgt aattgattaa tcactaatga gaaaactgtg ctaaaaaaag gatgaaaaaa
    16981 acatggctaa agctacgtca acatctataa atcgccaaaa ggaaatcata tctgctgcca
    17041 ttgaagtgtt tgcagagatg ggctactacc gagctacgac agccaaagtt gcggaacggg
    17101 ccaatatttc tcaaccctat gtctttcgtt ttttcgctac caaggaagca ttgcttgttg
    17161 aagccctgaa ggtttcattt acacgtatca tagactcttt tcacagggtc attcattcgg
    17221 cctcatctga acagcttgag caagagctaa ttgcagccta ttcgcaaatt atgatggaat
    17281 accgcaatga aacacttttg caaatgcagg cgcagacgat ccgcgaggat gaggtcgtaa
    17341 gcgtgatgca gcaaggattc cgtgaaattc atacgacggt ttatgatgct ttccgacggg
    17401 caggtattga acaagcaatg gaaagaacga tgctttttct cgccagaggt atgctgtgta
    17461 atatttcgat gtcgctggat ctgccagaac tgatgaaaaa agacgattaa ttttgtttta
    17521 tgcattagag tcgcgttttt gcgcggcttt ttttgctttt aattttattt tttcaagaca
    17581 tgatttcgtt tgcttctgag aaaaaacggc caaataagtt gacaagagaa gcgagtctcg
    17641 ttatcctaat acccataggg gtatatgtat aaagaaattt aactaagcta agccccctca
    17701 aaaaacaggc ggaggttata caatgtcatc aactaacaat atccaagcag atcatattct
    17761 tgattgcaaa gggctagctt gtcctatgcc tatagtaaaa acaaaaaagg ctatgaatga
    17821 gctcgttccc ggaaagatta tggaggttca ggcgactgac aaaggttcat tagccgattt
    17881 tcagagctgg gccaaaaaca ccggacatca atatttgggc actctccaag aaggagatgt
    17941 aatgcgacat tatttacgca aagcaaatcc ggctgaagtg aagaaggagc aaatattttc
    18001 ttctacgata agccatgaag agctacaagc aaaatgttcg ggaaaagaga acttcatttt
    18061 gcttgatgtt cgtgaacccg ctgaatttgc gcttaaatat atccctggat ctaagcacat
    18121 ccctcttggc gaactggaga acagactctc tgaactgaac ttggaagaag agatcgcagt
    18181 gatttgtcaa gctggagcac gcagtgaaat ggcttgtcag ttattagttt ccaaaggcgc
    18241 taaaaaagtc aaatctgtgc tttcaggcat atccgaatgg gctggagaga ctaagggaag
    18301 cgaatccata tgagtacgac agcaggaatt tatgcaaata atcaagaaca tgctcagtcc
    18361 aaaacaacga ttgtattatt cagcggggag ctggataagg cgattgctgc attcattatt
    18421 gcgaatggag cggcagcata tgatcatgaa gtaactattt tctttacttt ttgggggcta
    18481 aacacgttac gcaaggatga aatcgtgagc accaataagg gaatactcga aaaagccttt
    18541 ggctggatca tgcctcgtgg accccaaaag cttgcactat ccaaaatgaa ttttgccgga
    18601 cttggtccac agatgatcaa gcatgtcatg aaaaagcaca aggcgctttc cttgccggag
    18661 cttatagagt tggcacgaga gcaggggatc aagctcgtcg cctgtaccat gaccatggat
    18721 ttgttagggc tgcagcaaga tgagctaatc gacggtttgg aatatgctgg agtagccgcc
    18781 tacttggggg atgcttcgca gggcaaggtg aatctattta tttagggtat cctatttatt
    18841 tttttggttt ataatatacc tatacgtgta tatggtaagt caaaaaagga gtgcattact
    18901 tatggattac aattacagtg atgaactgaa aacgcgcctg aggaggattg agggacaggt
    18961 gcgtggggta cttcgtttaa tggatgaagg aaaatcgtgc aaagacgtcg ttagccagct
    19021 atctgccgta cgtaacgcat cagataaagc gattgcccaa attgtagcag agaatctgca
    19081 acgatgtata ttggaagagc aagaggcggg aggagacacg gataagctgg ttaaagaagc
    19141 gattcagctt cttgtgaaaa gtagataatc atgactccag agtccaagct agcgggcaat
    19201 gatgtcacta tgcacaaaat tacgggagct ggcatattgc ctttacccag ccacatatat
    19261 tggacgtggt taagagtttt ttgataaaca tctgaaagat taagattata tactagccgt
    19321 aattaaaaag ttcgctgcct ctagttggta gcgggctttt ttaatcgggc attttaggaa
    19381 tacccctctg tttaatgctg aggtagacag gtgtaaataa cacataaaga aaacaacttc
    19441 ttccgggagg catacttatg gaggtatttg ttacgatcgg tgtcaaattg atcatcagct
    19501 tttttggctt gtggatcatt acttttatta caggtcggaa aacactcagt cagttaacac
    19561 cactcgattt cctaacttca ttggtgttaa gcgaaattgt gggaaatatg ttatatgacg
    19621 ataaggtgac cattgggcag cttttgtttg ctttggcact atggtgcgcg ctggcctatt
    19681 tttttgaaaa ggcgatgacc cgttttgtga aatttggcta tatggcagaa ggtcgaacag
    19741 tgctgctcgt ggataagggg caagttaatc aagaaatgct tgaaaaatat gatatagaat
    19801 ttacccagct gctctccatg ctacgccagc aaaatatttt ttctctgcgt gaggtctggt
    19861 acgccacgtt agaaacgaat ggttcattgt cagtcatgcg caaacccgaa tacgagccac
    19921 ccgccgctca ggatatggga atagatgcac agcctgatct tttttctgtt acagtcattg
    19981 ataaaggaaa gcttctgaac gaatctatgc gtgggaagtc aatcgatatt gaagagatta
    20041 aagcaaaagt gcgagagcag ggatatgata gtatcgacga gattgcctat gcagagttta
    20101 gcgaggatgg aacacttcat gtagtgccga tgaacgagaa taagcatcaa aaaagtggtg
    20161 gatctattta aaggaatgat gggtttacta cggttctgcg atttttgctc tgtatggtgt
    20221 agctgctgag atagaggcat aacttcgggg tattgaacta tcatctcctc atgaagagga
    20281 ctgtttattt gtcttttttc tttttttaat aataactgta agcagtaaca aagggaggaa
    20341 aatttgaaaa ataggaaacc aggtattaag tacattgata aagcatatct ttgccctgca
    20401 accctaaaat atacgctatt tttatgaatt ggatacttag cgaaagacat ttggaagcct
    20461 cataattctc cgaatttcgc aaatcaacca ccacagggtc tagaggagtt acattataga
    20521 atatttgagt tccggattga ggagactacc tcttatgggt ttgaaatttt ttcagaaagt
    20581 ggtgatcagt ttgagtttct cggatgatca gcttatctgt ctccggtttg aggacgaact
    20641 agggtatttt gctaaggctg ctgctcctcc aatttatgag actgctccat ttttctttga
    20701 tacttacgaa gattatgctg aagcggctaa taatgaaaag gagcattatg tctattcgag
    20761 gggaaccaat cctaccgttc agattgcaga gcaaatgatt gctgcgctgg aaggtggggc
    20821 ggactgcaag tgctttgctt ccggaatggc tgctatcagt gccgctctaa tgtgtagctt
    20881 atccgcaggg gaccatctga ttctggtcgg acacatatat gaaacctccg tcagcctagc
    20941 ccgatattta aagaggttcc atatagacta tacaatcgta cattcgactt ctacagaagc
    21001 agtcgctggt gccatcaaac cacagacccg tgctattctt atggagtctc ctacctcatt
    21061 cacattcgat atggtaaatg ttcaggaggt aacttcgctt tccaaagcga agggtatacg
    21121 cacaatcata gataattcat gggctacacc ccttttccaa aaacctttgg aatggggcgt
    21181 agatatcgtt gttcactccg catccaagta cttgggtggt cataatgatt taattgcagg
    21241 ggcagtgatc gcttctaaag agataataaa ccgtatgtat gctgaagagt atgagttgat
    21301 tggcggctcg ttgggccctt ttgaagcctg gctactcatt cgggggctaa gaacactccc
    21361 gctccgaatg gaagcccatc aaaggaatgc tctgttggtt gctcgttttc taacagatca
    21421 tccggccatt tccaaagtga atcatcccgg acttccttct catccacaac atgagctcgc
    21481 atgtagacag ctcaaaggct atgccggatt attcagtttt gaactaaagg attcgactta
    21541 tgaagatata tgtaaagtga ttaataaact gcgactgatc cggatcggtg tatcttgggg
    21601 gtccatggag agccaggtga tctcaccaaa ctacggcttc aataagcaga gtctaaaaaa
    21661 acaacacatg cctgaatcgc ttatccgctt ggctgtaggg catgagcctg ctgaactttt
    21721 gatacaggat ttagctacag ctttaagcta aacgaacatt tcaggatttt cttaaaagct
    21781 aaagcagcag ctcatccaat acataaagag cttctgcttt tctggtttat gacgtttata
    21841 cctgatcaac tttgcacttt aagtaggaga taagagagtt tcggttgtta cagataaatc
    21901 attgtgtgtt ggagtgtttt aataaaaact acaccgtgta gaaatacaaa ctattgaaat
    21961 gggaaatatt acaacttgcc tgatagatat acacgtgata aattatatat ccagccagtt
    22021 aaacggctgt tgatttgatc tttgaaaact gaacaacgag tgagtacgga ttttgtttac
    22081 aaaatccaac gctgagattt tggtacatgc cgtcaggctg tatgaaatgg aagcgaaaat
    22141 gagatatttt atctcgtcag tttcaaaat
//
