LOCUS       NZ_POVS01000015        20679 bp    DNA     linear   CON 15-SEP-2024
DEFINITION  Paenibacillus sp. F4 F4_contig_14, whole genome shotgun sequence.
ACCESSION   NZ_POVS01000015
VERSION     NZ_POVS01000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus sp. F4
  ORGANISM  Paenibacillus sp. F4
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 284534)
  AUTHORS   Jeong,H., Park,S.-Y., Choi,S.-K., Ryu,C.-M. and Park,S.-H.
  TITLE     Genome sequencing and comparative analysis of polymyxin-producing
            Paenibacillus strains
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 284534)
  AUTHORS   Jeong,H., Park,S.-Y., Choi,S.-K., Ryu,C.-M. and Park,S.-H.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JAN-2018) Infectious Disease Research Center, Korea
            Research Institute of Bioscience and Biotechnology (KRIBB), 125
            Gwahak-ro, Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 11-JAN-2018
            Assembly Method                   :: CLC Genomics Workbench v. 11.0
            Assembly Name                     :: F4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 524.4x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_002894905.1-RS_2024_09_15
            Annotation Date                   :: 09/15/2024 04:37:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,419
            CDSs (total)                      :: 5,299
            Genes (coding)                    :: 5,203
            CDSs (with protein)               :: 5,203
            Genes (RNA)                       :: 120
            rRNAs                             :: 10, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 1 (5S, 16S)
            partial rRNAs                     :: 2, 1 (16S, 23S)
            tRNAs                             :: 102
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 96
            CDSs (without protein)            :: 96
            Pseudo Genes (ambiguous residues) :: 0 of 96
            Pseudo Genes (frameshifted)       :: 42 of 96
            Pseudo Genes (incomplete)         :: 67 of 96
            Pseudo Genes (internal stop)      :: 14 of 96
            Pseudo Genes (multiple problems)  :: 22 of 96
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:44:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 43410
            Orig. end                         :: 64089
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            POVS01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20679
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20679
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20679
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10679](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10679
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     gene            98..901
                     /locus_tag="C1T21_RS17080"
                     /old_locus_tag="C1T21_17080"
     CDS             98..901
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019687439.1"
                     /locus_tag="C1T21_RS17080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17080"
                     /product="discoidin domain-containing protein"
                     /protein_id="WP_103049097.1"
                     /transl_table=11
                     /translation="MKKACITILFLVLLSLPVSNAFAAETEYSENLIPKMTSNNLPSGV
                     ASASNEFSYAYRSFDGDFATISSAWGSNENTAWLRYDFPKPEVIEQYVIYPQTTATDRA
                     PKDWTFEGSNDGVTWNVLDTQSNITEWVDSTPKKFTFSNSNSYKDYRINITANNGSQYI
                     TLGELEMMSKVSSSTPNPGTEEPTPNGDRAILVVTMTTGLEKEFDLSMKEVNDFIAWYE
                     GKQAGSGSASYAINKHDNNKGPFSSRKDYMLYDRILTFEVSEYSK"
     gene            complement(950..1813)
                     /locus_tag="C1T21_RS17085"
                     /old_locus_tag="C1T21_17085"
     CDS             complement(950..1813)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014599900.1"
                     /locus_tag="C1T21_RS17085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17085"
                     /product="ATP-dependent DNA ligase"
                     /protein_id="WP_103049098.1"
                     /transl_table=11
                     /translation="MFISPMLLETAAGPFSDSRYIFEPKIDGHRLIYSQQNGIVRLFTR
                     HNNDCTRQYPEISSALFPYDVVLDGEIACVDPMAGISDFESVMSRFQAKKTDKIMQLTA
                     SLPVTFVVFDILSYKGEDLRSLPLMERKAILAELTLPNANFGIVPYIEGAGEALFDQIQ
                     ARNMEGVVAKRKDSTYVSRRSAAWQKVINWSYADVFITGYRKAEFGWLAGVPTSSGGKM
                     RPSGIIEFGATPTHKKAFYGVSKQLITGEDREYVYVEPKIKARVKIRNWTKAGLLRSPV
                     FTEFIV"
     gene            1970..2197
                     /locus_tag="C1T21_RS17090"
                     /old_locus_tag="C1T21_17090"
     CDS             1970..2197
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686522.1"
                     /locus_tag="C1T21_RS17090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17090"
                     /product="hypothetical protein"
                     /protein_id="WP_103049099.1"
                     /transl_table=11
                     /translation="MNHTYKVLGSDIEPFAAALSQVRVYVVQPLGKDLIDIVDYGGVVE
                     KITPESIKINGSYFLCKQFEFRVDVKGSTG"
     gene            2346..3476
                     /locus_tag="C1T21_RS17095"
                     /old_locus_tag="C1T21_17095"
     CDS             2346..3476
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019687463.1"
                     /locus_tag="C1T21_RS17095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17095"
                     /product="fibronectin type III domain-containing protein"
                     /protein_id="WP_258012505.1"
                     /transl_table=11
                     /translation="MSKKFLTTVLTFFLISIMLLPSVTHAATKTVEGMLGFSPPDGTTV
                     KSSRNYTTDFNAEKAIDGNIQTPWNAGTYKGNIELNFPTAIEFNFVHITTNASPPRAVS
                     YTIYGLKEGKWVQISESITHTLKAANTTPPPIKVKQGAYSGIKIDGDGGSSWLAITEIT
                     LGTFETIDLTGQPQNASANLNWNTIKEATNYKINYGTQSNKYSDSISVEKDSEGNYVIP
                     NLTNGTTYYFQVVAIFNGVETVVSNEVAVTPNEAKTTEPTTPDNPSTGEPSKPSEPGTT
                     NPGEPSTGEPTNPQSPSGNRAILVVTMTSGLEKEFDLSIKEVNDFISWYESKQAGSGSA
                     SYAINKHDNNKGPFSSRKDYMLYDRILTFEVSEYSK"
     gene            3731..4876
                     /locus_tag="C1T21_RS17100"
                     /old_locus_tag="C1T21_17100"
     CDS             3731..4876
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019687462.1"
                     /locus_tag="C1T21_RS17100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17100"
                     /product="hypothetical protein"
                     /protein_id="WP_103049100.1"
                     /transl_table=11
                     /translation="MSISLRIERKSGGEPIEFVKGEIIGFTYKNNSSINLSAKSPNLAH
                     SLHIRSKIPLHSLPSVIDNADNSNMLYTWANTEYKPDSEDYYRKCNIQIVRNENTIRDI
                     TFTHAYVDKYQEQIDTSKEILEFELVLKQKEDQLGKIQYSPQLEPKETREKDQSDVSPK
                     VLEGAYSKNMLVYAGNNTFPFENPMVELEKTWVRGVEKVKDSTDTVIHFPDRKAFTLVA
                     VPIARKKYGDITANLLQHSLDYKPGHLHFNEWSYEAQQIKKSKEHNMYVIDKAVQKAND
                     KKVKSFSSDGSIAIESDRDLYNAFHKMKYKIDGTYVKGQWEITTIYYDKYNFEYNFKQM
                     FTGDNKLGWAAANLTNLMESWGTLNEYTSYVTVTDTKKAWK"
     gene            4981..5280
                     /locus_tag="C1T21_RS27390"
                     /old_locus_tag="C1T21_17105"
     CDS             4981..5280
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013370304.1"
                     /locus_tag="C1T21_RS27390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17105"
                     /product="hypothetical protein"
                     /protein_id="WP_258012506.1"
                     /transl_table=11
                     /translation="MRKYPYGKDTLEFFGDGTFQIYRGEGAGEPPILYTHQIEAPNSVI
                     DNVLSYKIEKNIVYVVGENSFIKLDSSTNTYEKKKRISDFTSKDREIFNKLTEK"
     gene            5778..6046
                     /locus_tag="C1T21_RS17115"
                     /old_locus_tag="C1T21_17115"
                     /pseudo=""
     CDS             5778..6046
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004230095.1"
                     /locus_tag="C1T21_RS17115"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17115"
                     /product="CPCC family cysteine-rich protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGKYTCPCCGYKTLDDEPPGTYDICEICFWEDDGIQFADPDYDGG
                     ANIVSLRQGQQIIKYLALAKKNA"
     gene            6189..6272
                     /locus_tag="C1T21_RS28485"
     CDS             6189..6272
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF028245.5"
                     /locus_tag="C1T21_RS28485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative holin-like toxin"
                     /protein_id="WP_223822117.1"
                     /transl_table=11
                     /translation="MEVKDTLMLMIQFATLVILILSFHKRK"
     gene            complement(6494..7168)
                     /locus_tag="C1T21_RS17120"
                     /old_locus_tag="C1T21_17120"
     CDS             complement(6494..7168)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C1T21_RS17120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C1T21_17120"
                     /product="hypothetical protein"
                     /protein_id="WP_103049102.1"
                     /transl_table=11
                     /translation="MKKPVYKKWWFWVIIVIVISGIGNMGKDKEENKNASDTGTKQSTP
                     VDATQKSTPEKKIETPVAVSDPKKEAADKKMKQQLVINFENTFFSVENSGATVFNKYKS
                     DMDSLGKGKTDVLTVYGSTKDAKDTALSLMSQYNELEVPNALPSEVKDLLEQSKRHLAT
                     AYYSKSEAFNSVLSYLDEQKPSYMNDFEENIKLADQDTMQGVLKLMQAKEKVGLKITEK
                     KK"
     misc_feature    7282..7295
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 23.52"
                     /tool="antismash"
     gene            7335..7670
                     /locus_tag="C1T21_RS17125"
                     /old_locus_tag="C1T21_17125"
     CDS             7335..7670
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016818450.1"
                     /locus_tag="C1T21_RS17125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17125"
                     /product="YolD-like family protein"
                     /protein_id="WP_103049103.1"
                     /transl_table=11
                     /translation="MSKKLEGNGLWESSRIIIPEHKEAYLKLMQDRQRRGKPELDDQEV
                     RLIEQALIESYNTRQPVTLVVFSPFDDEELKGVITSINTARREVKLFRGEDDYSWIKLE
                     DIISASI"
     gene            7784..8851
                     /locus_tag="C1T21_RS17130"
                     /old_locus_tag="C1T21_17130"
     CDS             7784..8851
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012774.5"
                     /locus_tag="C1T21_RS17130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17130"
                     /product="thermonuclease family protein"
                     /protein_id="WP_103049104.1"
                     /transl_table=11
                     /translation="MRSNGKGKIIGIIFAVIVAVAIIKYLGLLIIAGGLGYWGYKKYQN
                     AKRENQKSKLAIVLFSLAGIFFLAFIGNLTNVKQQELVNKAPAVPAKVEQTSVVPTTTK
                     SEQTSNIVSTSASNEKADSEQPKRIPITLIAGTDGDTFKASVQGKEEKIRLLLVDTPES
                     VKQGTPVQPFAKEASAFTLKQLKQGNLSLELDVSKRDKYGRLLGYVWVGDKMLNAMLIE
                     KGYARVAYINPPNVKYVDQFKEIQATAQKSGTGIWSIENYAQEDGFNQKAAQKATAKTE
                     SKSNDSSVKESKPKVVTPKKEVVQTYSEPRESSSNVYYKNCSAVRAAGADPIYEGEPGY
                     SRKLDRDGDGVACER"
     misc_feature    7814..7827
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: weak, score: 15.78"
                     /tool="antismash"
     gene            8945..9205
                     /locus_tag="C1T21_RS17135"
                     /old_locus_tag="C1T21_17135"
     CDS             8945..9205
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016091296.1"
                     /locus_tag="C1T21_RS17135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17135"
                     /product="group-specific protein"
                     /protein_id="WP_071558635.1"
                     /transl_table=11
                     /translation="MIEISIDEKEAKKLILKKVSELVEVVDAEYIFWDTKELKKRTCMS
                     WNAILDTFFYDPRFIKRKIGRKWYFPARETRAFLEQWLLEQ"
     gene            9187..10023
                     /locus_tag="C1T21_RS17140"
                     /old_locus_tag="C1T21_17140"
     CDS             9187..10023
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C1T21_RS17140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C1T21_17140"
                     /product="hypothetical protein"
                     /protein_id="WP_258012507.1"
                     /transl_table=11
                     /translation="MAFRTIDILRGLSIRLFLLEFYITSRKKITLHMHNLYQITLLIGL
                     PLIGSKCSIKSVLVTNYAKGLCDMWEPIRFLLFSTVETFAAFVLMLTIFRVRALDYVWP
                     ALFIGLIMNLQSFILREETSLSFFAPTINIILFTLLITTVVRMPIIWAAIISITGTFLY
                     TLFQAVIILMLFGTLTTEMQTSAEGSLAQAVTSAWVLAVSWFLYKFNIGFTADYENLRF
                     RWEHVLVVILIIGVLAACTFMFYFNNFFLSILFITLASVMFLYYALKTERDYHKKS"
     gene            10001..10555
                     /locus_tag="C1T21_RS17145"
                     /old_locus_tag="C1T21_17145"
     CDS             10001..10555
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009372 - quorum sensing [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821995.1"
                     /locus_tag="C1T21_RS17145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17145"
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_071558637.1"
                     /sec_met_domain="AgrB (E-value: 1.1e-19, bitscore: 64.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITIKSLDSIALDIATHIKTVVPDHPAPVNVLKHGIAVTINTVSI
                     VLLTIGISVFTDKIQEAVLAMISFSMLRQTVGGIHLKSNIACIIVSTVLLTALSFASFN
                     YNWIVITSIISIVLVLVYAPSRLEGKTRISKRHYPLLKFSGVAIIALNLWLALPVVGAS
                     FFVQSLTLIGGGVRNEEKQTE"
     gene            10533..10679
                     /locus_tag="C1T21_RS17150"
                     /old_locus_tag="C1T21_17150"
     CDS             10533..10679
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821994.1"
                     /locus_tag="C1T21_RS17150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17150"
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_071558638.1"
                     /sec_met_domain="TIGR04223 (E-value: 1.6e-09, bitscore:
                     31.9, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKNKLSKVKAGMYYNIAAMLTTLAVASVSTASLSWIHSPEPPKE
                     LLK"
     gene            10695..11090
                     /locus_tag="C1T21_RS17155"
                     /old_locus_tag="C1T21_17155"
     CDS             10695..11090
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014599896.1"
                     /locus_tag="C1T21_RS17155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17155"
                     /product="LytTR family transcriptional regulator
                     DNA-binding domain-containing protein"
                     /protein_id="WP_103049105.1"
                     /transl_table=11
                     /translation="MLSLTVSADPGGIDQGENVQVDKVLFISKGRKRDQILVHTIEKTY
                     YMIGTLRHWENFLNSNGFRFLNVDRSNTLNVEKVKIVNGIFKDAYFECDITKTSKRCPI
                     AYHRFEEVIKEMGFINSDIIFTGVATR"
     gene            11523..11726
                     /locus_tag="C1T21_RS17160"
                     /old_locus_tag="C1T21_17160"
     CDS             11523..11726
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C1T21_RS17160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C1T21_17160"
                     /product="hypothetical protein"
                     /protein_id="WP_071558640.1"
                     /transl_table=11
                     /translation="MVILLNEENQMKIKGNDTFTYSVENGGIKEVQVQSIVNEVWRYGG
                     KEISHEQLIKILNHIKVLASQG"
     misc_feature    11524..11540
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.81"
                     /tool="antismash"
     gene            12276..12458
                     /locus_tag="C1T21_RS17170"
                     /old_locus_tag="C1T21_17170"
     CDS             12276..12458
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014787.5"
                     /locus_tag="C1T21_RS17170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17170"
                     /product="hypothetical protein"
                     /protein_id="WP_258012529.1"
                     /transl_table=11
                     /translation="MAFKGKNFKLTLNAKYVLDVLKVLENEVTTLGYTGSSKPFTLESD
                     RKLWIRDRFLFLKIC"
     gene            complement(12540..12902)
                     /locus_tag="C1T21_RS28075"
     CDS             complement(12540..12902)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040350.4"
                     /locus_tag="C1T21_RS28075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6199 family natural product biosynthesis
                     protein"
                     /protein_id="WP_223822083.1"
                     /transl_table=11
                     /translation="MLLPTQIKIAPSHGGQSPLIFLLSFLEGRYFPSIVLFWYSLLKGA
                     DPMGFMLILIAIIFFSLGILSKRNPTWGWRANEAWKIKGDSEPSDAYIDDMKFRGSVSI
                     LFGFFFLTCGLLVIFL"
     gene            complement(12880..13314)
                     /locus_tag="C1T21_RS17185"
                     /old_locus_tag="C1T21_17185"
     CDS             complement(12880..13314)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821989.1"
                     /locus_tag="C1T21_RS17185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17185"
                     /product="hypothetical protein"
                     /protein_id="WP_103049106.1"
                     /transl_table=11
                     /translation="MTRLLDARTSQNASYGNTISIPLPANTPVAIAELGLDVTGAGENM
                     RVQLSGIAELAFPTPPPFDSVISFSIVRGNFDSLVAYALYSVSVSEANPNAVQVVTINA
                     SDYNVPLPPSNKLVDTLYLFCTADATRIGIESFNAVAYSD"
     gene            13556..14326
                     /locus_tag="C1T21_RS17190"
                     /old_locus_tag="C1T21_17190"
     CDS             13556..14326
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369887.1"
                     /locus_tag="C1T21_RS17190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17190"
                     /product="adhesin"
                     /protein_id="WP_103049107.1"
                     /transl_table=11
                     /translation="MFRHYCWQKSMHRRKFRRCVVKKVKVLPKVIVKGIRGPQGPQGPQ
                     GPQGPQGPQGPQGLPGPQGVPGAQGQQGLQGFQGIPGPTGPAGAVGPAGPVGPAGAVGP
                     AGAVGPAGATGAAGPAGAGITDFLSVFRADPGTGTDTVPGNSPITFTGVLANVGGAFTF
                     TPPSTTITINETGSYLINFTIHNQGDADFNLTVNGIPVTPVPFTGNGGGPISAEVIITV
                     GVVPTTIQLVNANATPAQLHNFTNTTLTILKLTV"
     gene            14973..15182
                     /locus_tag="C1T21_RS27080"
     CDS             14973..15182
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014599919.1"
                     /locus_tag="C1T21_RS27080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_146032504.1"
                     /transl_table=11
                     /translation="MSNGISDSERPNMTIPTIRALMKAKNRNREFEIILHGGKLENKKP
                     KKAKSLSDLSKLRSIHNHEVTPVK"
     gene            complement(15204..15401)
                     /locus_tag="C1T21_RS28490"
                     /old_locus_tag="C1T21_17195"
     CDS             complement(15204..15401)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025063.5"
                     /locus_tag="C1T21_RS28490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17195"
                     /product="IS3 family transposase"
                     /protein_id="WP_180984606.1"
                     /transl_table=11
                     /translation="MSRKGNCWDKACIENFFSNFKTECFYLHSFHSAQQVEHAVQKYIH
                     FYNHERFQEKLNNLTPFQAA"
     gene            complement(16176..16334)
                     /locus_tag="C1T21_RS28080"
     CDS             complement(16176..16334)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013677.5"
                     /locus_tag="C1T21_RS28080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_308411645.1"
                     /transl_table=11
                     /translation="MSFKIKTVDLYLKKGIGYKNVAREMEIDASLVRRWARHFKAEGMK
                     DLEENET"
     misc_feature    complement(16508..16522)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.06"
                     /tool="antismash"
     gene            17120..17713
                     /locus_tag="C1T21_RS17210"
                     /old_locus_tag="C1T21_17210"
     CDS             17120..17713
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014280979.1"
                     /locus_tag="C1T21_RS17210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17210"
                     /product="stalk domain-containing protein"
                     /protein_id="WP_103049110.1"
                     /transl_table=11
                     /translation="MNKKMYMFIGALLGVLLVTSGGAAADQVKSLVGKTVAGEYNVRVN
                     GTTLSENAIAVDGTAYVPLRSISESLGANLAVKRKTIEIATGTPSSNVVVKEQSQAIAL
                     KDNPYTNWSKELIVKHIGTVEELIEILNNNIKKYEKSLTDIDRKIGAAGDDQRLIERIE
                     KSATKTKKELQESKDSLLEHKKELEQLKAALATK"
     gene            complement(17853..18307)
                     /locus_tag="C1T21_RS17215"
                     /old_locus_tag="C1T21_17215"
                     /pseudo=""
     CDS             complement(17853..18307)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013371528.1"
                     /locus_tag="C1T21_RS17215"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17215"
                     /product="GyrI-like domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKAEIEKIPSCRIAYMRQIGPYGIANSQIMEKFKGWVKSNNLFNN
                     TSIILGIAQDNPAFVKPENCRYDACLVLSDDYCVNTDEVSLSNISGGRYAVLK"
     gene            complement(18489..19292)
                     /locus_tag="C1T21_RS17220"
                     /old_locus_tag="C1T21_17220"
     CDS             complement(18489..19292)
                     /EC_number="3.6.1.27"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0050380 - undecaprenyl-diphosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016311 - dephosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009592232.1"
                     /locus_tag="C1T21_RS17220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17220"
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="WP_103049111.1"
                     /transl_table=11
                     /translation="MTDVIKAIILGIIEGLTEFLPVSSTGHLILAGNLLSFDGDAAITF
                     KIVIQLGAVMAVLILYWKRYLEIGANLIRMDFSQSKGLNVIHMILAMLPALIVYLLFKD
                     TIKSQLFGPTPVLIGLVAGGLLMIIAARSRRTKTTDTIDGINYKQAFGIGLFQCLALWP
                     GFSRSGSTISGGLLLGTSQKAAADFTFLISVPVMFGASLLDLYDSRELLNSDDIYLMLI
                     GFTTSFLVAMIAVVTFIKLIKRLGLEWFALYRFVLAALFYLIVIQ"
     misc_feature    complement(19385..19400)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            19776..20264
                     /locus_tag="C1T21_RS28085"
     CDS             19776..20264
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015340.5"
                     /locus_tag="C1T21_RS28085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phage antirepressor KilAC domain-containing
                     protein"
                     /protein_id="WP_258012508.1"
                     /transl_table=11
                     /translation="MSKDTFIPENIFYRLAMKARNEVAEAFQAKVADEILPSIRKHGIY
                     ATDTVIDNILNNPDFGIELLTKLKEERAARVQAERTNAILMHVNKTYTATEIAKELGFK
                     SAIALNHDLGNRMIQFRQNDTWLLYSRFTDCGYVEIKQEVLDNGKVIYHHRFTQLGRE"
     gene            20351..20566
                     /locus_tag="C1T21_RS17230"
                     /old_locus_tag="C1T21_17230"
     CDS             20351..20566
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014599910.1"
                     /locus_tag="C1T21_RS17230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C1T21_17230"
                     /product="hypothetical protein"
                     /protein_id="WP_103049112.1"
                     /transl_table=11
                     /translation="MAKIKSTLDIQLDLTRPIEELTEVISAVIASQPARRKEILKGLDI
                     AIGDALAEIQAQEDQKTDNDSSGKVS"
ORIGIN
        1 tttagattat atttatagat tagcaagttt atgtttagac acatttcctc aattaaatta
       61 ttcttagttc tattaaacat attggaggat taccttaatg aaaaaagcat gtataacaat
      121 tttattttta gttcttttat ctcttccggt gtcgaatgct tttgcagccg agacagagta
      181 ttcagaaaat ttaattccaa aaatgacatc taacaatttg ccatctggag tggcaagtgc
      241 gagcaacgaa ttttcatacg catatagatc ttttgatggg gattttgcta ctatctctag
      301 tgcttgggga tctaacgaaa acactgcatg gttaagatat gactttccta aacctgaagt
      361 tattgaacaa tacgttatat atccacagac aacggcaacc gaccgggccc ctaaagattg
      421 gacttttgaa ggctcaaatg atggggttac ttggaacgtg ctagacactc agtcaaatat
      481 cacagaatgg gtagatagca ctccaaaaaa attcactttt tctaattcta attcatacaa
      541 ggactataga attaatatta cagcaaacaa tggaagtcag tatataactc ttggcgaatt
      601 agagatgatg tctaaggtct caagttccac tcctaaccca ggaacagagg aaccgactcc
      661 gaacggggat cgtgcaattc tagtagtcac catgacaaca ggattggaaa aagaattcga
      721 cctaagcatg aaagaggtca atgactttat cgcatggtac gaaggtaaac aggctggttc
      781 tggatcagca tcctatgcca tcaataaaca tgacaacaat aaaggcccgt ttagcagccg
      841 aaaggattac atgctatatg atcgtatcct tacatttgaa gtaagtgaat attctaaata
      901 aaattgaaaa gctctgctaa ccttatggtc ggcagagctt tttgttttat tagactataa
      961 actccgtaaa caccggactc cgcagtagcc ccgccttagt ccagttccgt attttaacgc
     1021 gtgctttaat cttcggctcc acgtaaacat actcgcgatc ctcaccagtt attaactgct
     1081 tgctaacgcc atagaacgct tttttatgcg ttggtgtggc tccaaactca atgataccgg
     1141 atggacgcat ctttccacca ctcgatgtcg gaactcctgc cagccatcca aactcagctt
     1201 tccgataacc tgttatgaat acgtcggcat aggaccagtt aataaccttc tgccacgcgg
     1261 ctgaacggcg actgacgtac gtactatcct tccgtttagc aactacgcct tccatattgc
     1321 gcgcttgtat ctgatcgaat aatgcttccc cagcaccttc gatataagga acaatcccga
     1381 aattagcgtt aggaagtgtc agttcggcga gtatagcctt gcgctccatt agtggtagag
     1441 agcgtaagtc ttcgccttta tagctcagaa tatcgaatac aacgaatgta accggcaggg
     1501 aagcggttag ttgcatgatc ttgtccgttt tcttcgcctg gaagcgtgac ataacggatt
     1561 caaaatcgga tatgccagcc atcggatcaa cgcaggcaat ttcaccatcc agtacgacat
     1621 cataggggaa caacgcgcta gatatctcag gatactggcg cgtgcaatcg ttgttatggc
     1681 gcgtgaataa gcgtacaatg ccgttctgtt gcgaatatat taagcggtgg ccgtctattt
     1741 tcggctcaaa aatataacgc gaatctgaga atggacccgc tgctgtttca agtaacattg
     1801 gagaaataaa caattagacc acctcaagtt aattataacg ctcatttatg cagtagtaag
     1861 gcggtaagta ttggagagaa aaagctctgc taaccttaat tggtcggcag agctttgtgt
     1921 tgaagggatt accataccgt tcatcgaata aattattgag gtgatcagca tgaaccatac
     1981 atataaagtg ttagggtcgg atatagagcc gtttgcagca gcattaagcc aggtaagagt
     2041 atatgtggta cagccgttgg gtaaagattt gatagatatt gtggattacg gtggagtagt
     2101 ggagaagatt acaccggagt cgattaaaat taacggatct tatttcttgt gtaagcagtt
     2161 tgaatttaga gtagatgtga aaggctcaac cgggtaactg gtatgagtct tactaatacc
     2221 caataaaaaa taaatatgca aaaatataga ttatatttat agatcagcaa gtttatgttt
     2281 agacaatatg agagtgttaa tctatcttta tggatataga agatattcat agggggctaa
     2341 taatcatgtc aaagaaattt ttgactaccg ttctaacttt ttttctaatt agcatcatgt
     2401 tactaccatc agttacacat gcagcaacta aaacagtcga gggaatgctt gggttttcac
     2461 ctccagatgg aactactgta aaatctagca ggaattatac aacggatttc aatgcagaaa
     2521 aggcaattga tggaaatata caaacgcctt ggaatgccgg gacctacaaa ggaaatattg
     2581 aattaaattt tccaactgct attgagttta attttgtcca tatcaccact aatgcatcac
     2641 caccaagagc agtttcatat acaatctacg gactaaaaga gggtaaatgg gttcaaataa
     2701 gcgaaagtat aactcatact ttgaaagctg caaatacaac gccaccccct attaaggtaa
     2761 agcagggcgc gtatagtggt ataaaaattg atggagatgg tggttcgtct tggttagcaa
     2821 ttaccgaaat cactctggga acgtttgaaa ccatagatct tacaggccaa ccacagaatg
     2881 cgtctgctaa cttgaactgg aatacaatta aagaagctac gaactacaaa attaattatg
     2941 gaacccaatc caataaatat tctgactcaa tttctgtaga aaaagattca gaaggtaact
     3001 atgtcattcc aaatttgacg aacgggacga cttactattt tcaagtagta gctattttta
     3061 atggagtcga gactgttgtt tctaatgaag ttgcagttac accaaatgaa gctaaaacga
     3121 ctgagccgac aacacctgac aatccttcaa cgggggagcc aagtaaacca agcgaacctg
     3181 gtacaacaaa tcctggcgaa ccatcgactg gtgagcctac taatcctcaa tcaccatcag
     3241 gtaaccgcgc tattttggta gttactatga catcaggatt ggagaaggaa tttgacttaa
     3301 gcataaaaga ggtcaatgac tttatctcct ggtacgaaag taagcaggct ggttctggat
     3361 cagcatccta tgcgataaat aagcatgaca ataataaagg tccattcagc agccgtaagg
     3421 actacatgct atatgatcgt atcctaacat ttgaagtaag tgaatactct aaataaatta
     3481 aaagctctgc taaccttaat tggtcggcag agcttttatc gtttctaaca ggtctgtgtt
     3541 aggctagcat atatttcgtt ttagcttctt catataattt gccgaggtta cgaaactcta
     3601 ttgtcgccct ttaccatgtt gaaaatatgt ttactattta atatttttcg tatatattaa
     3661 tatttggaaa ttagtttttc acaaatattt cctacaaaac tagattgaat taacagagga
     3721 gattatttca atgagcattt cattaagaat agaacgcaaa tccggtggtg aaccaatcga
     3781 gtttgtaaaa ggtgaaatca ttggctttac ttataagaat aatagttcca taaacctttc
     3841 agctaagtct ccaaacttgg ctcattcgct acatattcga agcaaaattc cgcttcattc
     3901 gcttccttca gttatagaca atgcggataa ttccaacatg ctgtatacat gggcaaacac
     3961 agaatataaa cctgatagtg aggattacta tcgcaaatgt aatatccaaa tcgttagaaa
     4021 tgaaaacaca atccgagata ttacgtttac acacgcttat gtagataagt atcaagaaca
     4081 gattgatacc agcaaagaga tccttgagtt tgaacttgtt ttaaaacaaa aagaagatca
     4141 attgggaaaa attcaataca gtcctcagtt agaacctaag gaaacaagag aaaaggatca
     4201 gtctgatgtc tcgccaaaag tactggaagg tgcatatagt aagaatatgt tagtgtatgc
     4261 aggaaataat acttttccgt ttgaaaatcc tatggtagaa ctagaaaaga cttgggtacg
     4321 aggcgtagag aaggtaaaag attcgacaga cactgtaata cattttcctg atcgtaaagc
     4381 atttacatta gtagctgttc ctatagctcg aaagaagtac ggggacatca cagccaattt
     4441 acttcaacat tcccttgatt acaaaccagg acatttacac tttaacgagt ggtcgtatga
     4501 agcgcagcaa attaaaaaat ccaaagaaca taatatgtat gtaattgata aagcagtaca
     4561 aaaagctaac gacaaaaaag ttaaaagttt ttcaagtgat gggtctattg caattgaaag
     4621 tgacagagat ttgtataacg cttttcacaa aatgaagtac aaaatagatg gaacatatgt
     4681 aaaaggacaa tgggaaatta ctacaatata ttatgataaa tataattttg aatataattt
     4741 taaacaaatg tttactgggg acaacaaact cggttgggct gcggccaatc taacaaattt
     4801 aatggaatca tggggaacac tcaatgagta tacatcttat gttacagtaa ctgatacaaa
     4861 aaaggcttgg aagtgaggtg tgaattgcag atgaaacgca gatacaagat ttacatcttg
     4921 atctctctac tagttataac tactactata atttatctgg caaattctgg agacgacacg
     4981 atgaggaagt acccttatgg aaaagatacg ttagagtttt ttggagatgg gacttttcag
     5041 atttacaggg gggaaggagc gggtgagcct ccaatactat acactcatca aattgaagct
     5101 cctaattcag tgattgataa cgttctgtct tataaaatag aaaaaaatat cgtatatgtg
     5161 gttggtgaaa atagcttcat taaattggac tcaagtacca acacatatga gaaaaagaaa
     5221 cggatttccg actttacttc caaagataga gagatattta ataaattaac ggaaaaatag
     5281 aagctatcat aaacaaatgt ggtagcaagg gagatttaac ttgttcacaa aggttaactt
     5341 aacatgcgct ttagttgagc tattgttatg taagtattct aaatttataa agaatggtta
     5401 ccaccagtgg tgatattatg attattaaaa ttgaaggtta cttttttcag aatttgatta
     5461 ctggtcccct atgcacacaa gaagaactat atcaaaagta tatacaagca aaaatgctga
     5521 gtcttaatat tagagattta cctgatatat tttgtcgact tcataatttt gatcgattac
     5581 gttttgaaga tgacacagag gttggtttcg tgattgatac agatacggac aggatataca
     5641 gaccgatata ttgatgttta aagcggttta tccaaaagat atgttcctat ctcctttaat
     5701 tacaagtaat gaaggactca cataactagc taacggaaca aaaaaataga tacataataa
     5761 ggagaggtct tatagcggtg ggaaaatata cttgtccttg ctgtggttac aaaaccttag
     5821 acgatgaacc gcctggaacc tatgatattt gtgaaatttg tttttgggaa gatgatggta
     5881 ttcagtttgc agatcctgat tatgatggag gggcaaacat agtatcttta agacagggcc
     5941 agcaaattat aaagtatttg gcgcttgcga agaaaaatgc atagagtttg tgagaaaagc
     6001 cttagataaa gatatacgcg acccgaactg ggaaccctat aactaactgg aacgctagtt
     6061 caaaattgaa ttctattaat taaacaagct cgggacctac ctggggcttg gttgtggtat
     6121 aatctggatt gtgcgacaaa acggctataa agggcggtcg gctaatctcc cggaagggag
     6181 gtgacgccat ggaagttaaa gacacgctga tgttgatgat tcaattcgca acgttggtga
     6241 ttctgatact ttctttccat aaacggaaat agaccgccct ggcgaggata cggtctattt
     6301 ctggatcaaa cctcaattgc tgaccgctct tatagcggta agtcgtacag gggagcggta
     6361 gtagccgttc cctttttcta ttcttatgtt atcatattca ttttatacag gcaatggaat
     6421 tacctctgtt gacaatagtc ataatggtta tagaaatatt aaaaccccgg attgctccgg
     6481 ggctctttgt gcattacttc ttcttttcag taattttaag accgactttc tcttttgctt
     6541 gcattagttt aagaacacct tgcattgtgt cctgatctgc taatttgata ttctcttcga
     6601 agtcattcat ataactaggt ttttgttcat caagatatga gagtactgaa ttaaatgctt
     6661 cacttttaga gtaataggca gttgccaagt gtcttttgga ttgttcaaga agatctttaa
     6721 cctcagaagg caaagcattt ggaacttcaa gctcattata ttgtgacatt aacgataaag
     6781 ctgtatcttt tgcgtcctta gttgatccat ataccgtcaa cacgtcagtc ttacctttac
     6841 ctaaggaatc catgtctgat ttatatttat tgaatacagt tgctccactg ttctcaacac
     6901 taaaaaatgt gttctcaaaa ttaataacca gttgctgctt cattttttta tctgctgctt
     6961 ctttcttagg atcagaaaca gcgacaggcg tttcaatttt cttttctggt gtggatttct
     7021 gcgtggcatc taccggagtg gattgttttg tacccgtatc actagcgttc ttattctctt
     7081 ctttatcttt acccatatta cctattccgc taatcacaat aacaataatg acccaaaacc
     7141 accacttctt ataaacaggt ttcttcaagc tttttttctc cccctaatgg atcagtaata
     7201 tattccatat atagtctatc agacctagga atatttttct agcaaaaaag ttttagatac
     7261 agcatgcaaa aagtcttgtc tagaacatat gttcggaata taatttctac ataacacatc
     7321 aggaggctac atacatgtcg aaaaaattag aaggtaacgg cttatgggaa agcagtcgga
     7381 ttatcatacc agaacacaag gaagcatact taaaactcat gcaagaccgc cagcggagag
     7441 gcaagccgga acttgacgat caggaagtcc ggttgatcga gcaagcgctt atagagtcct
     7501 acaacacacg tcaacctgta acactggtgg tttttagccc gttcgatgac gaagaactca
     7561 aaggtgtaat cacgtctata aatactgctc gcagggaagt aaaactgttt cgtggcgaag
     7621 atgattatag ttggatcaag ttggaggata ttatttcagc aagtatctag cagataaatc
     7681 tagagaatag taaaatatcc gtgcgatttt tgtaataaaa gtatatatat tggaaaatgt
     7741 tcatggtata tttatcctag aactaaatac ctagggggat atcatgagaa gtaatggaaa
     7801 gggaaaaatc ataggaatta tctttgcagt aattgtagct gttgcaatta ttaagtattt
     7861 aggattgctt attatagcag gagggcttgg ctactggggg tataaaaaat atcagaatgc
     7921 taagagagaa aatcagaaga gtaaactagc catagtttta ttttcacttg ccgggatttt
     7981 ctttttagcg ttcatcggga atctaacgaa tgttaagcag caggaattag tgaataaagc
     8041 accagctgtt ccagctaaag tagaacaaac ttctgtggta cctactacaa ctaaatctga
     8101 gcaaacttca aacattgttt ctacctcagc atctaacgaa aaggcggatt ctgaacaacc
     8161 aaaacgtatt cctataactt taatagcggg aacggatgga gatacattta aagcatcagt
     8221 tcaagggaaa gaggaaaaga ttcgactact cctagtagat acgccagaaa gcgtaaaaca
     8281 gggtacacca gtccaaccgt tcgcaaaaga agcttcggct tttacgctga agcaattaaa
     8341 gcagggtaat ctttccctag agcttgatgt ttcaaaacga gataagtatg gtcgtctact
     8401 tggttatgta tgggttggag ataagatgtt gaatgcaatg ttaatcgaga aaggttatgc
     8461 tcgggtggcc tacataaatc ctccaaacgt taaatatgtc gatcaattca aggagattca
     8521 agctactgct caaaagagtg gaacaggcat ctggagtatt gaaaactatg cgcaagaaga
     8581 tggattcaat cagaaggcag ctcaaaaggc aactgcaaag actgaatcta aaagtaatga
     8641 ttcaagtgta aaagaatcta agcctaaagt agttactcct aaaaaggaag tcgtccaaac
     8701 ttattctgaa ccaagagaat catcaagcaa tgtatactat aaaaactgtt ctgcggttcg
     8761 tgctgctggt gccgatccaa tttatgaagg tgaaccaggt tatagtagga aactggatcg
     8821 tgatggtgat ggagtagctt gtgaaagata atctttgtta aaaactattc ctcggtgcat
     8881 atccgaggaa tttttatgat ttcattaatt aatactacac tctacaaaaa gagggatgag
     8941 aattttgatt gagattagta tagatgaaaa ggaagcgaaa aaacttatat tgaaaaaagt
     9001 ttcggagttg gtggaagtag ttgatgctga atatatattt tgggatacaa aagaattgaa
     9061 gaagagaact tgtatgagtt ggaatgcaat cctcgatacc tttttttacg atccgagatt
     9121 tatcaaacgg aaaataggga ggaaatggta ttttccggct cgtgaaacga gagccttctt
     9181 agaacaatgg cttttagaac aatagatatt ttaagaggct tgtctataag gttatttttg
     9241 cttgaatttt atataacttc acgtaaaaaa attaccttac atatgcacaa tttataccaa
     9301 attacactgc taattggatt gccactcatt ggtagcaaat gtagtattaa aagtgtgctt
     9361 gttaccaatt atgcgaaggg gttatgtgat atgtgggagc ctataaggtt cttgcttttt
     9421 tcaactgtag aaacttttgc agcgttcgtt ttaatgttaa ctattttcag agttagggca
     9481 ttagactatg tatggcctgc attgtttatt ggattaataa tgaatttgca gagctttatt
     9541 ttgagggaag agacatcgtt atctttcttt gctccaacca taaacattat attgttcaca
     9601 ttattgataa ccactgttgt tagaatgcca attatttggg cagctataat atccattaca
     9661 ggcacatttc tatatacgtt attccaagcg gtaattatat tgatgctctt tggtacatta
     9721 acaactgaaa tgcagacttc agcagaagga tcattggcgc aagcagtaac tagcgcatgg
     9781 gtgttagctg tttcgtggtt tctgtataaa tttaatatag gctttacagc agattatgaa
     9841 aatctccgtt ttaggtggga acatgtactt gttgttatct taataatcgg ggtactagct
     9901 gcttgtacat ttatgtttta ctttaacaat ttctttctga gtattttatt cataacccta
     9961 gcatctgtaa tgtttttgta ttatgcatta aaaacggagc gtgattacca taaaaagtct
    10021 tgactccatc gctctagata tagcaacaca catcaaaact gttgtccccg atcatccagc
    10081 acccgtaaat gttttaaaac atgggatagc cgttacgatc aacacagttt caattgtttt
    10141 gctaactatt ggtatttcag tttttacgga taagatacaa gaagctgtgc tggcaatgat
    10201 atctttttcg atgctacgtc aaactgtagg aggcatacat ttaaagagca atatagcgtg
    10261 tattattgta tctacagttc tacttaccgc tttatctttt gcaagtttta attacaattg
    10321 gatcgtcatt acttcgataa taagtattgt acttgtcttg gtttacgcac catcacggct
    10381 agaggggaag acacgcatat caaagcgaca ctacccattg ctaaaatttt cgggagttgc
    10441 aattattgca cttaatttgt ggttggcttt accggtagta ggcgctagct tttttgttca
    10501 gagtttaaca ctaataggag gaggtgtgag aaatgaagaa aaacaaactg agtaaagtaa
    10561 aggctggtat gtattacaat attgctgcaa tgctaacaac acttgctgtt gcgtcagtta
    10621 gcacagcaag tctttcttgg attcatagcc ccgagccacc gaaagaattg ttgaaataag
    10681 cgaggaatga caaaatgcta agtttaacag tatcggcaga ccctggaggt attgatcaag
    10741 gcgaaaacgt acaagtggat aaggttcttt ttatatctaa agggcgtaag agagaccaga
    10801 ttttagttca cacaattgaa aagacttact acatgattgg aacccttaga cattgggaaa
    10861 actttttgaa cagtaacgga ttccgttttt tgaatgtgga cagaagtaac actcttaatg
    10921 tagaaaaagt aaaaatcgtt aatggtattt tcaaagatgc ttactttgag tgtgatataa
    10981 caaaaacctc aaaaaggtgc cctattgcgt atcatcggtt tgaagaggtt ataaaagaga
    11041 tgggtttcat taattcagac ataatattca cgggagttgc tactagatag caactctttt
    11101 ttttgttgaa aatattgtat ttaaatgtcg aaaaatgata cacatccagc gcctgaattt
    11161 atgttgccaa agaacctaat aatgggattt aatatatgtt agtggatata attcttaaac
    11221 aaggaataaa gtagaggaat gatgaatgtt attgctccga atataatatg ggaaaagtga
    11281 ttactaatta ctacccattc gtatagatct ttcatcctac aaccgaagaa ttgagcagcg
    11341 tgtacatatc ttttagattt tattaccgtc atttcttaga agtgagaaat aatgcgctgt
    11401 ggtcagtaga tcttcgcaca tattccgttg ggatccaact tttctgtttt agaaggaagt
    11461 aaataagatt ttagcttgtc agtaaacaac gatttaatta tacgatttag gagaggtcta
    11521 ttatggtaat tttattaaat gaagaaaacc agatgaaaat caaaggaaat gatactttta
    11581 cttattctgt tgaaaacgga ggtattaagg aagtacaagt acagtcaata gtgaatgaag
    11641 tttggagata tggcgggaaa gaaatatcac acgaacaact cataaaaata ctaaatcaca
    11701 taaaagttct tgcatcacaa ggataaaaaa atagctttag catatgacca ctaaagctat
    11761 tttcttgacc gcattttgac cgcgcttttt aaagatttaa gtgtatttga aagtatattg
    11821 ataatctgaa cataatatat tttgcagtat actcaagaga gaaaatatgt tgaaacccaa
    11881 aggaatactg agtgcttttg tatcgcaccc aagtacatca atgggaacgc gatcaatatc
    11941 tgactcttta ctaaaatggg aaatcccttg gcgctctaag cgttgaggga ttttttgtgt
    12001 gtggtaggta aaaaaattta ttaagttgat ttataattgc cccctaattg ccccccaaaa
    12061 tttttattat cagaataaat tttcagtaac agactcatag ttctccatgc tattcatctc
    12121 tatttttttg gagatgtgtg cataaacgtc ggctgttatt tggatgctac catgtccaag
    12181 ccactcctgt acatacttca ttgtagccct agcttcaagt agcaataccg catgatttta
    12241 tatatgcgtt tgcccgaaca gaaagcataa cgccaatcgc tttcaaggga aaaaatttca
    12301 aactaacgtt gaatgcaaaa tatgtgttgg atgtcttgaa agtcttagaa aacgaagtga
    12361 ctacactcgg gtatactggc tcttctaaac cattcactct cgagagtgac aggaagctat
    12421 ggataagaga cagatttctg tttttgaaaa tatgctaaat gatattttag gagcttcagc
    12481 taaacagcaa gtgtcttttg gataaggaca ttttgaggat tgaaaacaga tagtagaact
    12541 tacaggaata taaccaaaag tccacatgtt aaaaagaaga acccaaagag aatcgataca
    12601 gagcctctaa atttcatgtc atcaatgtaa gcatcacttg gttctgagtc ccctttgatc
    12661 ttccaggctt cgtttgcacg ccatccccaa gtgggatttc gtttacttaa aataccaagc
    12721 gagaaaaaaa taatcgcaat aagaataagc atgaatccca ttggatcagc ccctttaagt
    12781 aaactatacc aaaaaagaac gatagatgga aagtatcgtc cctcaaggaa agatagaaga
    12841 aaaataagag ggctttgccc tccatgtgat ggtgcaattt taatctgagt aggcaacagc
    12901 attaaaactc tctattccta ttcgggtagc atctgctgtg caaaatagat ataaggtatc
    12961 caccaattta tttgatggtg gtagagggac attgtaatcg gaagcattta tggtgacgac
    13021 ctgtacagcg tttgggtttg cttcggagac acttacagag taaagggcgt aagcaacaag
    13081 cgaatcgaaa ttgcctctaa caatggaaaa agaaataacg gagtcaaatg gtggaggggt
    13141 aggaaatgca agctcagcta tcccggataa ttgtacacgc atgttttccc ctgcgcccgt
    13201 tacatctaag ccaagctcag caatggcaac gggagtattg gctggcaagg gaatagagat
    13261 tgtattaccg taacttgcgt tttgagatgt tcgagcatct aacaatctag tcattatctc
    13321 atctcccttt ttgggtaaag gatttgcaag ctggaaatat aaaaatacag acagtgtagg
    13381 atttggaccg gttaattgaa ctggatatta agcttcagaa ggatgagctg taataatgct
    13441 aacacgatag ggtcagacct atgcctattt tcccgaaatg aagtcaacag cccaatcttt
    13501 ttggttaatt gcacaataag ctactttgac tagactttgg aggtgaccat taattatgtt
    13561 tcgacattat tgttggcaga agagtatgca tcggagaaaa tttagaagat gtgtagttaa
    13621 aaaagtcaaa gtgttaccga aagttattgt taaagggatc cgaggacctc aaggacctca
    13681 aggacctcaa ggacctcaag gacctcaagg acctcaagga cctcagggac tgccgggtcc
    13741 acagggagtt ccaggtgctc aaggccagca agggctacaa ggttttcaag gaattcccgg
    13801 accaacagga ccagcaggag cagtagggcc agcaggacca gtgggaccgg caggagcagt
    13861 agggccagca ggagcggtag gaccagcagg agcaacgggg gcagcgggac ctgcaggcgc
    13921 cggtataaca gacttcttaa gtgttttccg agcagatcct ggcacgggaa ctgacacagt
    13981 tccgggtaac tcaccaatta cctttactgg agttttagct aatgttggtg gtgcatttac
    14041 tttcactcct ccatctacaa cgataacaat caacgaaacg gggagctatc taataaattt
    14101 tacaattcat aaccaaggtg atgctgactt taaccttacc gtaaatggaa tccctgttac
    14161 ccctgttccc ttcacgggta acggtggcgg accaatttcg gcagaagtca ttattactgt
    14221 aggggtcgtt cctacaacta ttcaattggt aaatgcaaat gcaaccccag cccaacttca
    14281 taactttacc aataccactc ttactatatt aaagttgact gtttaagcca ttcttaatga
    14341 tatatagaac atcatatgta gccgccttag aaaagactgt acgatttcca tcgtcagttt
    14401 gtctaattcc actcatatta agcagacgca attgtgtagc atggcaagag aatgtagtgg
    14461 cagtaataag atccattaaa cactaccact actccaaagc ctattttcaa agttgaactg
    14521 gataacattg taaaaattat attattcaga catagaaata tgaatgctaa gaaggtaagg
    14581 aaacttttcc taccttcttt tttattgtga caaatcggaa ctattgcttt gatccgtcag
    14641 gtacgacaac tcatgagcgg caatcaatat aaattttctt ttttgtttag tcgcgaaaaa
    14701 tgggaagcta cagaagaacg ggccgaggtc gattggccta aagttgagca ttgcataagg
    14761 aagcctttaa ccttgtgtgg gtagaaggac tgacggagga agtatacgag aatgtagaca
    14821 aagagggcat taaggagttg gatggcctct tagaacgatt tctataagga gttgtttcca
    14881 cctgatgaag attatgagcc tacgacgaag aagagcaaga ggttcctgag gatgatcgga
    14941 aaatagactg gatagaactt tgggctttat gcgtgagtaa tggtatttct gattcagaac
    15001 ggcctaatat gaccattcca acgattagag cgctcatgaa ggccaagaac agaaaccggg
    15061 aattcgaaat cattctccac ggtggtaagt tggaaaataa aaaaccgaag aaggccaagt
    15121 cactatctga tctaagtaaa ttaagaagca tccacaatca tgaagtgacc cctgtcaagt
    15181 agacagctat caaaaagcaa taattaagca gcctgaaaag gagtcaggtt gtttagtttc
    15241 tcttgaaagc gttcatggtt gtagaaatgg atatactttt gaacagcatg ctccacctgt
    15301 tgagctgaat ggaaggaatg gagatagaaa cactcggttt taaaattgct gaagaagttc
    15361 tctatacatg ccttgtccca gcagttccct tttcgggaca cctgtattcc gtatcgcttg
    15421 agcaggttgg tatattggcg agaggttgaa atccttggtc gctatgtagt ataacacctc
    15481 gagcatcttg tcgcttcctt gcctttttca ccgtaactaa caccaggctc aaatcgtttc
    15541 tgcggctgat ctgttaggca acaattacgt tgttaaaaag atgctgaatc gcggaagggt
    15601 agagtctcag tccattgaac attaggtaag tgatgtctat tacctacttc ttattcggct
    15661 ggtcagcctt aaactcctag ttcagatgat tgccaggaat gacgtagggt tctttcttgc
    15721 aataataggg ttttttccta cgaatgatcg cattgatccc cagttcacca taagtacgtg
    15781 gcttatgatt catatgtatg ctgtagattt aattcaatta aacctttacc ctgcggtaac
    15841 cgtatattcc cttcagttcc tcgtcacatg ccatgatttt tagcttcata gcttcatctt
    15901 cccgctgttt gggtgaaaca aacatctttc atgttatcca cttataaaaa ccacttttga
    15961 acactcgggc cagtttatat agtagtacta tgctatgtcc ctaactaagc aattcttgga
    16021 tcaccgcaaa ctttgtactc ttgggtacag cctccattcc tccgttgaca tctgcaagag
    16081 cttttttagc atttcatttt ctgcttcgag gcgtttcagc ttgacctccg gatcttcggg
    16141 gcgtgttcga ggtctgccga tgcctggccc ttttgctatg tctcgttttc ctctagatct
    16201 ttcattccct cggctttaaa gtgtctcgcc catcggcgaa ccagcgaagc gtcaatctcc
    16261 atttctcgtg ccacgttttt atatccgatt ccctttttga ggtacagatc cactgtcttt
    16321 atcttgaagc tcacatcgta agtttttctt atttctccta taaaaaaatc ccctccataa
    16381 tagacagatt agatggcttg ctcttttctg tctactatga gaggaacata tcacacttgg
    16441 agaggttttt acttttgtac gaatgaaagg agccaattgg gggccagtgc aagcctaata
    16501 tatgtatatc tcagattgcg aaaacatgag aaaaggaaat aatatgatga agcgaatcgg
    16561 agttttttta ttgatatcac tgctgccagc actcgctatt ttattcgtat gtggtttcca
    16621 tataagcgga ttgattttac ttttttcatt gatcttactg gcatacatgt atgtgcttat
    16681 aaatgaacag attcattttg ctcaatacgc aaagtcctct atggaaagat ttaatcgtga
    16741 cgtagaataa ttttcttctt gtaactataa taagtggttt caacaatgtt cctaactacc
    16801 tcggcttgtt tagaaattac aattttctcc gggatatata cctccaccag ggcctaatag
    16861 ttttgtctgg cagttggaat cattttacag gtaagacagg tcgaagaatt aaggttgatt
    16921 cattcggact tgtggcttat gccttaacag gacaagagac catttcttta ggtcgaagag
    16981 gttcgggtgg tagcttaatg ctcttgggtc gtagaagtcc tgtaggtggg ggtagcagtt
    17041 catgttcaac ataattgttt acgacaatat cttccaatgg taatatgaga acgaataaac
    17101 cgttagcgga ggcatttaga tgaataaaaa gatgtatatg tttataggtg ctttacttgg
    17161 agtactgcta gttacttctg gtggagctgc ggcagatcaa gtaaaatcac tagttgggaa
    17221 gactgttgca ggggaataca atgtgagagt aaatggaaca acattgtctg aaaacgctat
    17281 tgccgtcgat ggtacagcgt atgtaccttt gcgttcgatc tcagaatctc tgggggcgaa
    17341 cttagcggtg aagaggaaaa ctattgaaat tgcaacagga actccttctt ctaatgtggt
    17401 tgttaaagag cagtcacaag caatagcttt gaaagataac ccatatacca attggtccaa
    17461 ggaactaatt gtaaagcaca ttggaactgt ggaagaattg atcgaaatac ttaataataa
    17521 tattaaaaaa tatgaaaagt cattgactga catcgataga aaaataggtg cggcgggcga
    17581 cgatcaaaga cttattgagc gcattgaaaa aagcgccact aagacaaaaa aggaattaca
    17641 agaatccaaa gacagtttat tagagcataa aaaagagcta gaacaactta aagcagcatt
    17701 agctactaaa taaataagta gtaatctagt agcaaacaaa aattatatac tgtatacaca
    17761 aaagccctct taaacagagg gcttttactt ttataaaaga ggatagtatt agactgcttt
    17821 caataataga aacaacctat atcttaatac gtctattgaa tcggaacgca aatttcgcaa
    17881 taatgattat taataagttc aactgtatat cgctccaaga taggtctggt ttcatctaag
    17941 ctgaaccttt gattatccaa ctccaggaat atttcaatcc aagccttttg aacagcttct
    18001 gctgtatgat ttattttaaa acagcgtatc ttcctccact aatgttgctt agacttactt
    18061 catcagtatt aacacagtaa tcatcagaaa gaaccaaaca tgcatcgtag cgacaatttt
    18121 ctggcttcac aaatgcagga ttatcttggg caataccaag gataatagac gtattattaa
    18181 ataaattatt cgatttaacc caacctttaa atttctccat tatttgtgaa tttgcaattc
    18241 cataaggacc aatctgtctc atgtatgcaa ttctacaaga cggtattttt tcaatttcag
    18301 ccttcatatt ttcttctctt tctttttaaa gtacatcgat gtctgaaacc atcttataat
    18361 gctttaaaat gataaacaac tcaatttaaa aatagtcaaa ttagcgccta atacccaaag
    18421 agaagacata tgcgccttct caacaatgtg tgaatgatag tggagatatt tctttaataa
    18481 taaattggtt actgtatgac gattaaatag aagagagctg ctaagacaaa acggtatagg
    18541 gcaaaccatt ccaatccgag tcgcttaatt agtttgatga acgtcactac tgcaatcatc
    18601 gccacaagaa aggatgtcgt aaagccaatt aacattagat agatatcgtc agaatttagc
    18661 aactcgcgac tatcgtacaa atccaacaag cttgcaccaa acataacagg tacggaaata
    18721 aggaacgtaa agtctgcggc ggctttttgg ctagtgccaa gtaaaaggcc acctgaaatc
    18781 gtcgaacccg atctcgaaaa tcccggccac aaagccaaac attggaacag gccaatcccg
    18841 aaagcctgtt tataattaat cccatcaatc gtatcagtgg ttttagttct cctactccgt
    18901 gctgcgataa tcatcaacaa gccaccggca actaaaccga tcaagacggg agttgggccg
    18961 aataattggc tttttattgt gtccttgaag agaagatata cgattaatgc tggtaacata
    19021 gccaaaatca tatgaattac atttaatcct ttactttggg aaaaatccat tctaatcaga
    19081 ttagccccaa tctccaaata tcttttccaa taaagaatta gaactgccat cactgcacct
    19141 aactgtataa caattttaaa agttattgca gcgtcaccat caaagctaag caaattgcct
    19201 gctaaaataa gatgtccagt agacgatacc ggtaaaaatt cagttaagcc ctctattatg
    19261 ccaagtatta ttgctttgat tacatcagtc atcagtggct atcccccttc aaaaataaca
    19321 attcccagta taagggggac atttacatat tcccatcgat caacataaca atattctatt
    19381 cagagtgaca taattgtcac atttctcatt tataagtctt tttagagtta acctgccttt
    19441 tagcctaatg acgtatattc agtctaatgc tctatttcca cgaacaatac ttctctaaaa
    19501 tccgcagcgt tatagtaaca aaaccaattt aagatataag tataaaagcc tctgataact
    19561 caggggctta ttttgcgtac aaagaaaggt gagatcgtaa tggatatact tacaattcac
    19621 ggagtaagag gatttattga tggaaacggc acgccgcaat tgaatttgga ggatgtggct
    19681 cgaggattag gatttacaga caaatcaaat gtacagagta tgtcaaatag gatagagtga
    19741 ggcagtattt atcggatttg aagttttcga cagaagtgtc gaaagatact tttattcccg
    19801 aaaacatctt ttatcgactg gcaatgaagg caagaaacga agtagccgag gcatttcagg
    19861 ccaaggtagc tgatgaaata ctgccgtcga tcaggaagca tggaatatat gctacggata
    19921 ctgtgattga taatatcctc aataatcctg actttggaat tgaactgctg actaagctca
    19981 aggaagaacg tgctgccaga gtacaggcgg aaagaacaaa tgcaatccta atgcatgtta
    20041 acaaaaccta tactgccaca gagattgcca aagaactcgg atttaagtca gcaattgctc
    20101 ttaaccatga tttaggcaat cgaatgattc aattcaggca gaatgacaca tggttgttgt
    20161 atagcagatt tacggattgc ggctatgttg aaatcaaaca agaagttctt gataacggaa
    20221 aagtgatcta tcaccataga tttacacagt taggtcgtga atagcttgtg aaaatttata
    20281 ataaggagca attaaaggca tctgcaaact aaaggtgtct ttttttgtgt ctgagggagg
    20341 tgatgaaccc gtggcaaaaa taaaatctac attggatata caactggatc taacaaggcc
    20401 aattgaagaa ttgactgagg tcatttctgc tgtgatagct tcgcaaccag cgcgccggaa
    20461 agaaatactt aaaggtttgg atatagcaat aggagatgca ttagccgaga tacaggcgca
    20521 agaagatcag aaaacagaca atgatagctc aggaaaagtt tcctgaacgg agagacggag
    20581 gaaagaaggt tggataagtg ggagattttt aagttcagcg cagctttagg tagtagcgct
    20641 gtgacgtatt tttacggtgg gtggtcggga gtattgggg
//
